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Liliana Santos holds an MSc in Molecular Oncology from the Abel Salazar Biomedical Sciences Institute, University of Porto, and a PhD in Pharmaceutical Sciences from the Faculty of Pharmacy, University of Coimbra. Her doctoral research, conducted at the iCBR (Faculty of Medicine, University of Coimbra) and ICNAS Pharma Unipessoal, Lda., focused on elucidating the molecular mechanisms underlying brain metastasis formation in HER2+ breast cancer. Through her work, she identified key factors contributing to blood-brain barrier dysfunction, paving the way for novel diagnostic and therapeutic strategies. Since October 2024, Liliana has been a researcher on the European Union-funded project CHAngeing – Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function at iCBR. Her work focuses on evaluating the impact of bioactive compounds from the Mediterranean Diet in preventing blood-brain barrier dysfunction in cerebrovascular diseases.
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Identificação

Identificação pessoal

Nome completo
Liliana Santos

Nomes de citação

  • Santos, Liliana
  • Santos, L

Identificadores de autor

Ciência ID
5E1A-2C3C-DBB8
ORCID iD
0000-0003-2525-9572

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2020/07 - 2025/01/22
Concluído
 Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Uncovering the mechanisms behind blood-brain barrier dysfunction in HER2+ breast cancer brain metastasis: a step toward new therapeutic approaches" (TESE/DISSERTAÇÃO)
2019/11/04 - 2019/11/15
Concluído
 III Modular Training in Laboratory Animal Science (Outros)
Especialização em Especialização em Function A
Universidade de Coimbra, Portugal
 17.3
2015/09 - 2017/12
Concluído
 Molecular Oncology (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Role of Mitochondrial Dynamics in Hürthle Cell Tumors: Coupling, Uncoupling and Fission" (TESE/DISSERTAÇÃO)
 18
2012/09 - 2015/07
Concluído
 Biochemistry (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro, Portugal
 15
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/10 - Atual Research Fellow (Project: CHAngeing – Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/07 - 2025/01 PhD Student in Pharmaceutical Sciences Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2019/10/01 - 2020/03/31 Research Fellow (Project: BrainHealth 2020 – Early detection, neuromodulation and advance therapies for neuropathologies) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2018/05/01 - 2019/09/30 Research Fellow (Project: Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2016/04 - 2018/03 MSc student in Molecular Oncology Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Projetos

Projeto

Designação Financiadores
2024/10 - Atual CHAngeing – Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function
101087071
Bolseiro de Investigação
Universidade de Coimbra Faculdade de Medicina, Portugal
Em curso
2019/10/01 - 2020/03/31 BrainHealth 2020 – Early detection, neuromodulation and advance therapies for neuropathologies
CENTRO-01-0145-FEDER-000008
Bolseiro de Investigação
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/05/01 - 2019/09/30 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
SAICTPAC/0022/2015
Bolseiro de Investigação
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Liliana Santos; Francesca Tomatis; Hugo R S Ferreira; Sara F F Almeida; Edward Ciputra; José Sereno; Rui Almeida; et al. "ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in HER2-positive breast cancer". Neuro-Oncology (2024): https://doi.org/10.1093/neuonc/noae169.
    10.1093/neuonc/noae169
  2. Rita Carvalho; Liliana Santos; Inês Conde; Ricardo Leitão; Hugo RS Ferreira; Célia Gomes; Ana Paula Silva; et al. "Nerve growth factor inducible (VGF) is a secreted mediator for metastatic breast cancer tropism to the brain". The Journal of Pathology (2024): https://doi.org/10.1002/path.6319.
    10.1002/path.6319
  3. Santos, Liliana; Moreira, João Nuno; Abrunhosa, Antero; Gomes, Célia. "Brain metastasis: An insight into novel molecular targets for theranostic approaches". Critical Reviews in Oncology/Hematology 198 (2024): 104377. http://dx.doi.org/10.1016/j.critrevonc.2024.104377.
    10.1016/j.critrevonc.2024.104377
  4. Almeida, Sara F.F.; Santos, Liliana; Sampaio-Ribeiro, Gabriela; Ferreira, Hugo R.S.; Lima, Nuno; Caetano, Rui; Abreu, Mónica; et al. "Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling". Journal of Experimental & Clinical Cancer Research 42 1 (2023): http://dx.doi.org/10.1186/s13046-023-02886-9.
    10.1186/s13046-023-02886-9
  5. Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R. S.; Sereno, José Vitor Oliveira; Almeida, Sara F.F.; Ferreira, Lino; Ana Paula F. da Silva; et al. "Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier permeability". Fluids and Barriers of the CNS 20 S1 (2023): http://dx.doi.org/10.1186/s12987-023-00417-4.
    10.1186/s12987-023-00417-4
  6. Almeida, Sara F.F.; Santos, Liliana; Ribeiro, Gabriela; Ferreira, Hugo R.S.; Lima, Nuno; Caetano, Rui; Abreu, Monica; et al. "Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodeling". BioRxiv (2023): https://publons.com/wos-op/publon/61870053/.
    10.1101/2023.05.06.539690
  7. Ivanna Hrynchak; Liliana Santos; Amílcar Falcão; Célia M. Gomes; Antero J. Abrunhosa. "Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies". International Journal of Molecular Sciences 22 19 (2021): 10745-10745. https://doi.org/10.3390/ijms221910745.
    10.3390/ijms221910745
  8. Almeida, Sara; Santos, Liliana; Falcão, Amílcar; Gomes, Célia; Abrunhosa, Antero. "In Vivo Tracking of Extracellular Vesicles by Nuclear Imaging: Advances in Radiolabeling Strategies". International Journal of Molecular Sciences 21 24 (2020): 9443. http://dx.doi.org/10.3390/ijms21249443.
    Publicado • 10.3390/ijms21249443
  9. Lima, Ana Rita; Correia, Marcelo; Santos, Liliana; Tavares, Catarina; Rios, Elisabete; Canberk, Sule; Soares, Paula; et al. "S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma". Endocrine 73 1 (2020): 85-97. http://dx.doi.org/10.1007/s12020-020-02546-4.
    10.1007/s12020-020-02546-4
  10. Couto, Marina; Coelho-Santos, Vanessa; Santos, Liliana; Fontes-Ribeiro, Carlos; Silva, Ana Paula; Gomes, Célia M. F.. "The interplay between glioblastoma and microglia cells leads to endothelial cell monolayer dysfunction via the interleukin-6-induced JAK2/STAT3 pathway". Journal of Cellular Physiology 234 11 (2019): 19750-19760. http://dx.doi.org/10.1002/jcp.28575.
    Publicado • 10.1002/jcp.28575
  11. Lima, Ana Rita; Santos, Liliana; Correia, Marcelo; Soares, Paula; Sobrinho-Simões, Manuel; Melo, Miguel; Máximo, Valdemar. "Dynamin-Related Protein 1 at the Crossroads of Cancer". Genes 9 2 (2018): 115. http://dx.doi.org/10.3390/genes9020115.
    10.3390/genes9020115
Capítulo de livro
  1. Alves, Raquel; Jorge, Joana; Lapa, Beatriz Santos; Ribeiro, Ilda P.; Teles, Paulo; Góis, Inês Nobre; Santos, Liliana; et al. "Altered cell cycle regulation in the development of resistance". In Resistance in Hematologic Malignancies and Cancer, 193-213. Elsevier, 2025.
    10.1016/b978-0-443-21790-6.00005-5
Poster em conferência
  1. Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R. S.; Almeida, Sara F.F.; Edward Ciputra; Sereno, José Vitor Oliveira; Moreira, João Nuno; et al. "Tumor-secreted ENPP1 modulates BBB dysfunction during early brain metastatic progression". Trabalho apresentado em Brain Tumor Conference, 2024.
  2. Santos, Liliana; Hrynchak, Ivanna; Sereno, José Vitor Oliveira; Ferreira, Hugo R. S.; Célia M. Gomes; Abrunhosa, Antero J. "Exploring the therapeutic efficacy of [177Lu]Lu-DOTA-trastuzumab in trastuzumab-resistant HER2+ lesions". Trabalho apresentado em European Symposium on Radiopharmacy and Radiopharmaceuticals, 2024.
  3. Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R. S.; Almeida, Sara F.F.; Ribeiro, Ana Sofia; Ferreira, Lino; Ana Paula F. da Silva; et al. "Unraveling the role of HER2+ breast cancer cells-derived secretome on blood-brain barrier dysfunction in premetastatic niche formation". Trabalho apresentado em EACR Conference ’The Tumour Ecosystem: Cellular Interactions and Therapeutic Opportunities’ , Bergamo, Italy, 2024.
  4. Santos, Liliana; Hrynchak, Ivanna; Ferreira, Hugo R. S.; Sereno, José Vitor Oliveira; Célia M. Gomes; Abrunhosa, Antero J. "Therapeutic Efficacy of [177Lu]Lu-DOTA-Trastuzumab in Trastuzumab-resistant HER2+ lesions". Trabalho apresentado em CIBIT, 2023.
  5. Santos, Liliana; Ferreira, Hugo R. S.; Tomatis, Francesca; Almeida, Sara F.F.; Ribeiro, Ana Sofia; Ferreira, Lino; Ana Paula Silva; et al. "Evaluating Blood-Brain Barrier Permeability Changes during Premetastatic Niche Formation for HER2+ Breast Cancer Brain Metastasis". Trabalho apresentado em EACR 2023 Congress, Turin, Italy, 2023.
  6. Santos, Liliana; FERREIRA, HUGO; Tomatis, Francesca; Sereno, José Vitor Oliveira; Almeida, Sara F.F.; Ferreira, Lino; Ana Paula Silva; et al. "Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier permeability during the pre-metastatic niche formation". Trabalho apresentado em Champalimaud Research Symposium 2022, 2022.
  7. Hrynchak, Ivanna; Silva, Magda; Santos, Liliana; Amílcar Falcão; Célia Gomes; Abrunhosa, Antero. "GMP Production of 89Zr-DFO-Trastuzumab: from chemistry to the clinic". Trabalho apresentado em New Modalities in Cancer Imaging and Therapy, 2022.
  8. Almeida, Sara F.F.; Ribeiro, Gabriela; Abreu, Mónica; Lima, Nuno; Santos, Liliana; Oliveira, Rui C.; Miranda, Catarina O.; et al. "Osteosarcoma-derived secretome modulate the lung microenvironment and accelerate lung metastasis formation". Trabalho apresentado em Tumour Microenvironment: from cancer initiation to metastasis, Champalimaud Research Symposium 2022 (CRSy22), 2022.
  9. Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R. S.; Sereno, José Vitor Oliveira; Almeida, Sara F.F.; Ferreira, Lino; Ana Paula Silva; et al. "Trastuzumab-resistant HER2+ Brain Tropic Breast Cancer Cells Disrupt the Blood-Brain Barrier: a Potential Route for Brain Drug Delivery". Trabalho apresentado em 5th ASPIC International Congress, 2022.
  10. Hrynchak, Ivanna; Silva, Magda; Santos, Liliana; Falcao, Amilcar; Gomes, Celia; Abrunhosa, Antero. "Zr-89-immuno-PET imaging: from liquid target production to imaging". 2022.
  11. Almeida, Sara S.F.F. ; Sampaio-Ribeiro, Gabriela; Santos, Liliana; Lima, Nuno; Oliveira, Rui C.; Miranda, Catarina O.; Almeida, Luís Pereira de; et al. "Pre-metastatic niche formation and lung metastasis in osteosarcoma: an in vivo experimental approach". Trabalho apresentado em EACR Seed and soil: in vivo models of metastasis, 2021.
  12. Almeida, Sara F.F.; Ribeiro, Gabriela; Santos, Liliana; Lima, Nuno; Oliveira, Rui C.; Miranda, Catarina O.; Almeida, Luís Pereira de; et al. "Osteosarcoma cells secretome mimics the effect of a primary tumor in lung premetastatic niche formation". Trabalho apresentado em EACR Innovative Cancer Science 2021, 2021.
  13. Almeida, Sara F.F.; Santos, Liliana; Lima, Nuno; Oliveira, Rui C.; Martins-Marques, Tânia; Ribeiro-Rodrigues, Teresa; Girão, Henrique; et al. "Osteosarcoma cells-derived secretome induce endothelial cell dysfunction and stroma lung damage favourable for metastasis formation". Trabalho apresentado em Cancer Biology: From Basic to Translational Research, 2020.
  14. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "The VGF-derived peptide TLQP-21 released by breast cancer cells promotes the loss of brain endothelial cell monolayer integrity". Trabalho apresentado em CANCER BIOLOGY: FROM BASIC TO TRANSLATIONAL RESEARCH webinar organized by Liga Portuguesa Contra o Cancro, 2020.
  15. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "VGF-secreted peptide derived from brain metastatic breast cancer cells interferes with blood-brain barrier properties". Trabalho apresentado em Tumor Microenvironment (EACR-AACR Basic and Translational Research Conference in partnership with ASPIC), 2020.
  16. Novo, João Pedro; Santos, Liliana; Leitão, Ricardo Alexandre; Fontes Ribeiro CA; Rosa Cristina Simões Fernandes; Ana Paula Pereira da Silva Martins. "Effect of methylphenidate on microglia: an in vitro study". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences,, 2019.
  17. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "Secretome derived from brain metastatic breast cancer cells interferes with blood-brain barrier properties". Trabalho apresentado em CIBB Meeting, 2019.
  18. Carvalho, Rita; Cônde, Inês; Santos, Liliana; Leitão, Ricardo Alexandre; Gomes, Célia; Silva, Ana Paula; Paredes, Joana; Ribeiro, Ana. "Characterization of the secretome profile in brain metastic breast cancer cells". Trabalho apresentado em 2nd joint EACR-MRS conference - Seed and Soil: mechanisms of metastasis, 2019.
Pré-impressão
  1. Liliana Santos; Ivanna Hrynchak; José Sereno; Hugo Ferreira; Magda Silva; Rui Almeida; Paulo Teixeira; Antero Abrunhosa; Celia Gomes. "177Lu-Trastuzumab Radionuclide Therapy: an Effective Approach for Resistant Brain Metastases in HER2+ Breast Cancer". 2025. https://doi.org/10.21203/rs.3.rs-6180100/v1.
    10.21203/rs.3.rs-6180100/v1
  2. Carvalho, Rita; Santos, Liliana; Conde, Inês; Leitão, Ricardo; Ferreira, Hugo R. S.; Gomes, Célia; Silva, Ana Paula; et al. "Deciphering the impact of cancer cell’s secretome and its derived-peptide VGF on breast cancer brain metastasis". 2024. http://dx.doi.org/10.1101/2024.02.22.581537.
    10.1101/2024.02.22.581537
Tese / Dissertação
  1. Liliana Pereira Santos. "Role of mitochondrial dynamics in Hürthle cell tumours: Coupling, uncoupling and fission". Mestrado, 2017. https://repositorio-aberto.up.pt/handle/10216/109419.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2025/02 ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in HER2+ breast cancer V Metabolism, Ageing & Disease (MAD) Meeting
(Coimbra, Portugal)
2024/12 Tumor-secreted ENPP1 modulates BBB dysfunction during early brain metastatic progression CiBB meeting 2024
(Coimbra, Portugal)
2024/06 Disfunção da barreira hematoencefálica na metastização cerebral em cancro da mama II PhDoing: Da Pipeta ao Estetoscópio
(Coimbra, Portugal)
2024/01 Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier dysfunction during the premetastatic niche formation IV Metabolism, Ageing & Disease (MAD) Meeting Disease & Therapeutics: from the Past to Future
(Coimbra, Portugal)
2023/10 Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier dysfunction during the premetastatic niche formation ASPIC-ASEICA 2023
(Porto, Portugal)
2023/10 Therapeutic Efficacy of [177Lu]Lu-DOTA-Trastuzumab in Trastuzumab-resistant HER2-Positive metastatic lesions “Optimizing Imaging and Dose-Response in RadiotherapieS“ workshop
(Erquy, França)
2023/02 Trastuzumab-resistant HER2+ brain-tropic breast cancer cells interfere with the blood-brain barrier permeability: a potential route for brain drug delivery SPF 2023
(Coimbra, Portugal)
2022/09/21 Impact of HER2+ Brain-Tropic Breast Cancer Cells in Blood-Brain Barrier Permeability Blood Brain Barriers 2022
(Bari)
2020 VGF-secreted peptide derived from brain metastatic breast cancer cells induces brain endothelial cells dysfunction SPF 2020 - 50.ª Reunião da Sociedade Portuguesa de Farmacologia, 38.ª Reunião de Farmacologia Clínica e 19.ª Reunião de Toxicologia
(Coimbra, Portugal)
2018/02 Role of Mitochondrial Dynamics in Hürthle Cell Tumors: Coupling, Uncoupling and Fission Encontro de Investigação jovem da Universidade do Porto - IJUP
(Porto, Portugal)
2017/11 Role of Mitochondrial Dynamics in Hürthle Cell Tumors: Coupling, Uncoupling and Fission; 6th i3S Annual meeting
(Porto)

Membro de associação

Nome da associação Tipo de participação
2016 - Atual ASPIC and EACR member Sócio
Distinções

Prémio

2024 Flash talk award: Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier dysfunction during the premetastatic niche formation
2024 Best Flash Talk: Tumor-secreted ENPP1 modulates BBB dysfunction during early brain metastatic progression
2023 Best Oral Presentation Award: Impact of HER2+ brain-tropic breast cancer cells in blood-brain barrier dysfunction during the premetastatic niche formation
Associação Portuguesa de Investigação em Cancro, Portugal

Asociación Española de Investigación sobre el Cáncer, Espanha
2022 EACR Poster Prize: Trastuzumab-resistant HER2+ Brain Tropic Breast Cancer Cells Disrupt the Blood-Brain Barrier: a Potential Route for Brain Drug Delivery
European Association For Cancer Research, Reino Unido