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Bruno Victor graduated in Biochemistry from the Faculty of Sciences and Technology of the University of Coimbra in 2001. After two years as a research student, under the supervision of Claudio Soares, he started his PhD at ITQB-UNL. At that time, his project consisted of using different molecular modeling methods to study electron transfer proteins involved in the O2 and NO metabolism. After completing his PhD in biochemistry, he continued at ITQB-UNL where he started a Post-Doc project, focused on the study of the functional activity of hemagglutinin and several of its functional peptides in the infection of Influenza Viruses. During this period, with an HPC Europe 2 fellowship, he was also a visiting researcher at Xavier Daura Lab in Barcelona, where he had the opportunity to work with outstanding computational resources, such as the Barcelona Supercomputer. In 2012, he joined BSIM Therapeutics as a computational research scientist, to develop new methods and approaches (from chemoinformatics to Quantum Mechanics) to improve the identification and development of new therapeutic agents to treat Transthyretin-related amyloid diseases. During this period, he was involved not only in this company’s work but also in multiple drug discovery projects (from target and lead identification and validation, to in vitro evaluation) as an outsourced computational scientist, collaborating with different small biotech and drug discovery companies (GenePrediT and BiosolveIT). Although the results of some of those projects did not evolve into real applications, some others are still under development. One such promising example is the work I contributed to the development of a set of new therapeutic agents to prevent the formation of ATTR fibril formation in the peripheral and central nervous system. After this period in industry, he continued to develop his research focused on multiple drug discovery projects, in different academic groups, ranging from the University of Coimbra to the University of Lisbon. Between 2019 and 2023 he was an auxiliary researcher at the BioISI research center, where he coordinated the Structure-based drug discovery research group. During this time he supervised 1 Post-Doc, 3 PhD students, 13 Master thesis, and 5 undergraduate students. Under his supervision, the team has been involved in multiple drug discovery projects. During this time he coordinated several competitively funded projects by FCT (PTDC/BIA-BFS/28419/2017 - development of innovative methods to identify membrane Pan-Assay Interference Compounds (PAINS), and BioISI (BioISI projects call – 2020 - study of post-translational modifications in different metabolic enzymes). He also was part of other FCT-funded projects as part of the team, always responsible for the coordination of the computational work (PTDC/QEQ-MED/29036/2017 and PTDC/QUI-QFI/28455/2017). Moreover, he was involved in two collaborative projects with two international companies developing software tools for drug discovery (Lhasa and BiosolveIT), which are part of the PhD and Master projects of two of his students. In 2023 he joined Zymvol Biomodeling, a biotech company dedicated to protein discovery and engineering, with biotechnological applications. In May 2024 he decided to move to CoLAB AccelBio, to lead the computational medicinal chemistry research department to help setup and develop ongoing drug discovery projects Overall, he published 31 papers in specialized journals and he has registered 3 patents. His research is focused on Natural Sciences with an emphasis on Computational Biochemistry, Biophysics, and Medicinal Chemistry. During his professional activities, he has interacted and collaborated with 105 collaborator(s) during his scientific work.
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Identificação

Identificação pessoal

Nome completo
Bruno Lourenço da Silva Víctor

Nomes de citação

  • Victor, Bruno

Identificadores de autor

Ciência ID
5A17-09B5-48A5
ORCID iD
0000-0002-6472-5700
Researcher Id
L-2649-2016
Scopus Author Id
8791713500

Endereços de correio eletrónico

  • bvictor@accelbio.pt (Profissional)

Moradas

  • BioISI - Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Campo Grande, C8 building, 1749-016, Lisboa, Lisboa, Portugal (Profissional)
  • Colab Accelbio, Biocant Park, Parque Tecnológico de Cantanhede, 3060-197, Cantanhede, Cantanhede, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Italiano Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2007/11/29
Concluído
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Molecular modelling of redox proteins involved in the metabolism of O2 and NO" (TESE/DISSERTAÇÃO)
 Aprovado
2001/10/20
Concluído
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Interacção Molecular de Proteínas em Desulfovibrio gigas" (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/01/01 - 2023/05/31 Investigador Auxiliar (carreira) (Investigação) Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2017/10/01 - 2018/12/31 Pós-doutorado (Investigação) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2017/10/01 - 2018/12/31 Pós-doutorado (Investigação) iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa, Portugal
iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa, Portugal
2016/07/01 - 2017/09/30 Pós-doutorado (Investigação) Universidade de Lisboa Centro de Química e Bioquímica, Portugal
Universidade de Lisboa Centro de Química e Bioquímica, Portugal
2015/01/01 - 2016/06/30 Pós-doutorado (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2014/12/01 - 2016/06/30 Pós-doutorado (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2012/10/01 - 2015/01/30 Investigador (Investigação) BSIM2 Biomolecular Simulations Lda, Portugal
2008/01/01 - 2012/09/30 Pós-doutorado (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008/01/01 - 2012/09/30 Pós-doutorado (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/06/01 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/06/01 - 2024/04/30 Senior Researcher Zymvol Biomodeling, Lda, Espanha

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/05/01 - Atual Computational Medicinal Chemist Colab Accelbio, Portugal
2003/02/01 - 2007/11/30 PhD student Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2001/11/01 - 2003/01/31 Research Student (BIC) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2000/10/01 - 2001/09/30 Final Year Research Student Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projetos

Bolsa

Designação Financiadores
2025/01/01 - 2025/12/31 Membrane Permeability of Small Cyclic Peptides for Treating Sickle Cell Anemia
2024.13348.CPCA.A3
Co-Investigador Responsável (Co-IR)
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2024/12/31 Exploring respiratory proteins from human bacterial pathogens
PTDC/BIA-BQM/2599/2021
Investigador
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2024/01 - 2024/12 Expanding the “toolbox” of medicinal chemists: the role of halogen bonds in membrane permeability
2023.10475.CPCA
 Fundação para a Ciência e a Tecnologia
2022/02/01 - 2023/01/31 Structure-based database screening to support decision-making for endocrine disruptor identification
2021.09731.CPCA
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
Em curso
2022/09/01 - 2022/09/30 A natural polyphenol as a promising compound for cancer treatment
UIDP/04046/VerãoComCiência-2022
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas

Fundação para a Ciência e a Tecnologia
Concluído
2020/02/01 - 2021/03/31 Multidisciplinary approach to study post-translational modifications in metabolic enzymes
BioISI Projects call 2020
Investigador responsável
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas
Em curso
2016/10/01 - 2018/09/30 CpHMD-L simulations of pHLIP peptides: design of new tumor-targeted drug delivery systems
PTDC/QEQ-COM/5904/2014
Bolseiro de Pós-Doutoramento
Concluído
2014 - 2015 Diagnosis and treatment of three neurodegenerative diseases (Parkinson, Phenylketonuria and TTR amyloidosis)
NEUROMED
Bolseiro de Pós-Doutoramento
Universidade de Coimbra, Portugal
Concluído

Projeto

Designação Financiadores
2022/01/01 - 2024/12/31 Investigação de proteinas respiratorias de patogenos humanos bacterianos
PTDC/BIA-BQM/2599/2021
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/10/01 - 2022/09/30 Em busca de novos derivados de isoniazida eficazes no combate à tuberculose multi-resistente: uma abordagem integrada de química medicinal
PTDC/MED-QUI/29036/2017
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/10/01 - 2021/09/30 Targeting multi-resistant tuberculosis with new potent isoniazid derivatives: an integrated medicinal chemistry approach
PTDC/QEQ-MED/29036/2017
Investigador
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
Em curso
2018/10 - 2021/09 Deal with PAINS: strategies to spot membrane modulators
PTDC/BIA- BFS/28419/2017
Investigador responsável
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Uncovering blind spots in halogen bonding applications
PTDC/QUI-QFI/28455/2017
Investigador
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal
Em curso
2019/01/01 - 2019/12/31 Centro de Química - Coimbra
UID/QUI/00313/2019
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Química de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 Research Institute for Medicines
UID/DTP/04138/2019
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2015 - 2018 Research Institute for Medicines Strategic Plan - 2013/2015 - OE
UID/DTP/04138/2013
Bolseiro de Pós-Doutoramento
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Concluído
2011/03 - 2014/08 Membrane fusion mechanism of Influenza Hemagglutinin: a simulation and biophysical approach.
Provided by PTCRIS: 114774
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2008/01 - 2011/11 Microbial enzymes involved in superoxide and nitric oxide reduction
Provided by PTCRIS: 67263
 Fundação para a Ciência e a Tecnologia, I.P.
2000/10 - 2002/06 Structure function relationships of serine hydrolases in non-conventional media
PRAXIS XXI project PRAXIS/P/BIO/14314/1998
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Aljnadi, Israa M.; Bahls, Barbara; Duarte, Noélia; Victor, Bruno L.; Mendes, Eduarda; Camões, Sergio P.; Miranda, Joana P.; Maçôas, Ermelinda; Paulo, Alexandra. "Exploiting the 5-Amino-11H-Indolo[3,2-c]isoquinoline Core to Achieve Better G-Quadruplex Ligands for Cancer Therapy". ChemMedChem (2025): https://doi.org/10.1002/cmdc.202401019.
    10.1002/cmdc.202401019
  2. Vasco Neto; Bruno Lourenço Victor; Nuno Galamba. "Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease". Journal of Medicinal Chemistry (2023): https://doi.org/10.1021/acs.jmedchem.3c01484.
    10.1021/acs.jmedchem.3c01484
  3. Tiina J. Ahonen; Choa P. Ng; Beatriz Farinha; Bárbara Almeida; Bruno L. Victor; Christopher Reynolds; Eija Kalso; et al. "Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12". ACS Medicinal Chemistry Letters (2023): https://doi.org/10.1021/acsmedchemlett.3c00313.
    10.1021/acsmedchemlett.3c00313
  4. Inês Paccetti-Alves; Marta S. P. Batista; Catarina Pimpão; Bruno L. Victor; Graça Soveral. "Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24066004.
    10.3390/ijms24066004
  5. Sónia Zacarias; Marta S. P. Batista; Sofia S. Ramalho; Bruno L. Victor; Carlos M. Farinha. "Rescue of Rare CFTR Trafficking Mutants Highlights a Structural Location-Dependent Pattern for Correction". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24043211.
    10.3390/ijms24043211
  6. Claudia Istrate; Jéssica Marques; Pedro Bule; Sílvia Correia; Frederico Aires-da-Silva; Marlene Duarte; Ana Luísa Reis; et al. "In Silico Characterization of African Swine Fever Virus Nucleoprotein p10 Interaction with DNA". Viruses (2022): https://doi.org/10.3390/v14112348.
    10.3390/v14112348
  7. Pedro R. Magalhães; Pedro B. P. S. Reis; Diogo Vila-Viçosa; Miguel Machuqueiro; Bruno L. Victor. "Optimization of an in Silico Protocol Using Probe Permeabilities to Identify Membrane Pan-Assay Interference Compounds". Journal of Chemical Information and Modeling (2022): https://doi.org/10.1021/acs.jcim.2c00372.
    10.1021/acs.jcim.2c00372
  8. María Conde-Giménez; Juan José Galano-Frutos; María Galiana-Cameo; Alejandro Mahía; Bruno L. Victor; Sandra Salillas; Adrián Velázquez-Campoy; et al. "Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase". International Journal of Molecular Sciences 23 9 (2022): 4502-4502. https://doi.org/10.3390/ijms23094502.
    10.3390/ijms23094502
  9. Mendes, Eduarda; Aljnadi, Israa M.; Bahls, Bárbara; Victor, Bruno L.; Paulo, Alexandra. "Major Achievements in the Design of Quadruplex-Interactive Small Molecules". Pharmaceuticals 15 3 (2022): 300. http://dx.doi.org/10.3390/ph15030300.
    10.3390/ph15030300
  10. "In Silico End-to-End Protein–Ligand Interaction Characterization Pipeline: The Case of SARS-CoV-2". ACS Synthetic Biology 10 11 (2021): 3209-3235. http://dx.doi.org/10.1021/acssynbio.1c00368.
    10.1021/acssynbio.1c00368
  11. Enrico Cadoni; Pedro R. Magalhães; Rita M. Emídio; Eduarda Mendes; Jorge Vítor; Josué Carvalho; Carla Cruz; Bruno L. Victor; Alexandra Paulo. "New (Iso)quinolinyl-pyridine-2,6-dicarboxamide G-Quadruplex Stabilizers. A Structure-Activity Relationship Study". Pharmaceuticals 14 7 (2021): 669-669. https://doi.org/10.3390/ph14070669.
    10.3390/ph14070669
  12. Pires, Filipa; Geraldo, Vananélia P. N.; Rodrigues, Bárbara; Granada-Flor, António de; de Almeida, Rodrigo F. M.; Oliveira, Osvaldo N.; Victor, Bruno L.; Machuqueiro, Miguel; Raposo, Maria. "Evaluation of EGCG Loading Capacity in DMPC Membranes". Langmuir (2019): http://dx.doi.org/10.1021/acs.langmuir.9b00372.
    10.1021/acs.langmuir.9b00372
  13. Silva, T.F.D.; Vila-Viçosa, D.; Reis, P.B.P.S.; Victor, B.L.; Diem, M.; Oostenbrink, C.; Machuqueiro, M.. "The Impact of Using Single Atomistic Long-Range Cutoff Schemes with the GROMOS 54A7 Force Field". Journal of Chemical Theory and Computation (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85056302174&partnerID=MN8TOARS.
    10.1021/acs.jctc.8b00758
  14. Gaspar, H.; Bronze, S.; Oliveira, C.; Victor, B.L.; Machuqueiro, M.; Pacheco, R.; Caldeira, M.J.; Santos, S.. "Proactive response to tackle the threat of emerging drugs: Synthesis and toxicity evaluation of new cathinones". Forensic Science International 290 (2018): 146-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050077249&partnerID=MN8TOARS.
    10.1016/j.forsciint.2018.07.001
  15. Lousa, Diana; Pinto, Antonia R. T.; Victor, Bruno L.; Laio, Alessnadro; Veiga, Ana S.; Castanho, Miguel A. R. B.; Soares, Claudio M.. "Molecular determinants of the influenza fusion peptide activity". Free Radical Biology and Medicine 120 (2018): S125-S125. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000432836500398&KeyUID=WOS:000432836500398.
    10.1016/j.freeradbiomed.2018.04.413
  16. Machuqueiro, M.; Victor, B.; Switala, J.; Villanueva, J.; Rovira, C.; Fita, I.; Loewen, P.C.. "The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the pKaof the Distal Histidine". Biochemistry 56 17 (2017): 2271-2281. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018989755&partnerID=MN8TOARS.
    10.1021/acs.biochem.6b01276
  17. Vila-Viçosa, D.; Victor, B.L.; Ramos, J.; Machado, D.; Viveiros, M.; Switala, J.; Loewen, P.C.; et al. "Insights on the Mechanism of Action of INH-C10as an Antitubercular Prodrug". Molecular Pharmaceutics 14 12 (2017): 4597-4605. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037617710&partnerID=MN8TOARS.
    10.1021/acs.molpharmaceut.7b00719
  18. Ressaissi, A.; Attia, N.; Falé, P.L.; Pacheco, R.; Victor, B.L.; Machuqueiro, M.; Serralheiro, M.L.M.. "Isorhamnetin derivatives and piscidic acid for hypercholesterolemia: cholesterol permeability, HMG-CoA reductase inhibition, and docking studies". Archives of Pharmacal Research 40 11 (2017): 1278-1286. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029697150&partnerID=MN8TOARS.
    10.1007/s12272-017-0959-1
  19. Lousa, D.; Pinto, A. R. T.; Victor, B. L.; Laio, A.; Veiga, A. S.; Castanho, M. A. R. B.; Soares, C. M.. "Molecular determinants of the influenza fusion peptide's activity". European Biophysics Journal With Biophysics Letters 46 (2017): S222-S222. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000416406201299&KeyUID=WOS:000416406201299.
  20. Romão, C.V.; Vicente, J.B.; Borges, P.T.; Victor, B.L.; Lamosa, P.; Silva, E.; Pereira, L.; et al. "Structure of Escherichia coli Flavodiiron Nitric Oxide Reductase". Journal of Molecular Biology 428 23 (2016): 4686-4707. http://www.scopus.com/inward/record.url?eid=2-s2.0-84996538192&partnerID=MN8TOARS.
    10.1016/j.jmb.2016.10.008
  21. Lousa, D.; Pinto, A.R.T.; Victor, B.L.; Laio, A.; Veiga, A.S.; Castanho, M.A.R.B.; Soares, C.M.. "Fusing simulation and experiment: The effect of mutations on the structure and activity of the influenza fusion peptide". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84975041212&partnerID=MN8TOARS.
    10.1038/srep28099
  22. Manco, L.; Bento, C.; Victor, B.L.; Pereira, J.; Relvas, L.; Brito, R.M.; Seabra, C.; Maia, T.M.; Ribeiro, M.L.. "Hereditary nonspherocytic hemolytic anemia caused by red cell glucose-6-phosphate isomerase (GPI) deficiency in two Portuguese patients: Clinical features and molecular study". Blood Cells, Molecules, and Diseases 60 (2016): 18-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975485169&partnerID=MN8TOARS.
    10.1016/j.bcmd.2016.06.002
  23. Victor, B.L.; Lousa, D.; Antunes, J.M.; Soares, C.M.. "Self-assembly molecular dynamics simulations shed light into the interaction of the influenza fusion peptide with a membrane bilayer". Journal of Chemical Information and Modeling 55 4 (2015): 795-805. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928686003&partnerID=MN8TOARS.
    10.1021/ci500756v
  24. Lousa, Diana; Victor, Bruno L.; Fernandez, Carlos; Soares, Claudio M.. "Structural Properties of Membrane Inserted Fusion Peptide from Influenza Virus Analysed by Molecular Simulation". Biophysical Journal 106 2 (2014): 53A-53A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000337000400274&KeyUID=WOS:000337000400274.
  25. Lousa, D.; Victor, B. L.; Fernandez, C.; Soares, C. M.. "What is the role of the influenza fusion peptide in membrane fusion? A computational study". Febs Journal 281 (2014): 214-214. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359666801408&KeyUID=WOS:000359666801408.
  26. Victor, Bruno L.; Baptista, Antonio M.; Soares, Claudio M.. "Modeling the Structural Properties of the Transmembrane Peptide of Influenza Hemagglutinin in a Membrane Bilayer". Biophysical Journal 106 2 (2014): 53A-53A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000337000400275&KeyUID=WOS:000337000400275.
  27. Damas, J.M.; Filipe, L.C.S.; Campos, S.R.R.; Lousa, D.; Victor, B.L.; Baptista, A.M.; Soares, C.M.. "Predicting the thermodynamics and kinetics of helix formation in a cyclic peptide model". Journal of Chemical Theory and Computation 9 11 (2013): 5148-5157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887835236&partnerID=MN8TOARS.
    10.1021/ct400529k
  28. Antunes, J. M.; Victor, B. L.; Soares, C. M.. "Multi-scale simulations of the influenza virus transmembrane peptide in lipid bilayers". European Biophysics Journal With Biophysics Letters 42 (2013): S87-S87. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000330215300200&KeyUID=WOS:000330215300200.
  29. Victor, B.L.; Baptista, A.M.; Soares, C.M.. "Structural determinants for the membrane insertion of the transmembrane peptide of hemagglutinin from influenza virus". Journal of Chemical Information and Modeling 52 11 (2012): 3001-3012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870015416&partnerID=MN8TOARS.
    10.1021/ci3003396
  30. Seixas, S.; Ivanova, N.; Ferreira, Z.; Rocha, J.; Victor, B.L.. "Loss and gain of function in SERPINB11: An example of a gene under selection on standing variation, with implications for host-pathogen interactions". PLoS ONE 7 2 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857664937&partnerID=MN8TOARS.
    10.1371/journal.pone.0032518
  31. Gonçalves, S.; Borges, N.; Esteves, A.M.; Victor, B.L.; Soares, C.M.; Santos, H.; Matias, P.M.. "Structural analysis of Thermus thermophilus HB27 mannosyl-3- phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases". Journal of Biological Chemistry 285 23 (2010): 17857-17868. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952938697&partnerID=MN8TOARS.
    10.1074/jbc.M109.095976
  32. Victor, B.L.; Baptista, A.M.; Soares, C.M.. "Dioxygen and nitric oxide pathways and affinity to the catalytic site of rubredoxin: Oxygen oxidoreductase from Desulfovibrio gigas". Journal of Biological Inorganic Chemistry 14 6 (2009): 853-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349289240&partnerID=MN8TOARS.
    10.1007/s00775-009-0497-5
  33. Micaelo, N.M.; Victor, B.L.; Soares, C.M.. "Protein thermal stabilization by charged compatible solutes: Computational studies in rubredoxin from Desulfovibrio gigas". Proteins: Structure, Function and Genetics 72 2 (2008): 580-588. http://www.scopus.com/inward/record.url?eid=2-s2.0-46449090359&partnerID=MN8TOARS.
    10.1002/prot.21948
  34. Rodrigues, J.V.; Victor, B.L.; Huber, H.; Saraiva, L.M.; Soares, C.M.; Cabelli, D.E.; Teixeira, M.. "Superoxide reduction by Nanoarchaeum equitans neelaredoxin, an enzyme lacking the highly conserved glutamate iron ligand". Journal of Biological Inorganic Chemistry 13 2 (2008): 219-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-38649136959&partnerID=MN8TOARS.
    10.1007/s00775-007-0313-z
  35. Teixeira, V.H.; Cunha, C.A.; Machuqueiro, M.; Oliveira, A.S.F.; Victor, B.L.; Soares, C.M.; Baptista, A.M.. "On the use of different dielectric constants for computing individual and pairwise terms in poisson-boltzmann studies of protein ionization equilibrium". Journal of Physical Chemistry B 109 30 (2005): 14691-14706. http://www.scopus.com/inward/record.url?eid=2-s2.0-23844500381&partnerID=MN8TOARS.
    10.1021/jp052259f
  36. Victor, B.L.; Baptista, A.M.; Soares, C.M.. "Theoretical identification of proton channels in the quinol oxidase aa3from Acidianus ambivalens". Biophysical Journal 87 6 (2004): 4316-4325. http://www.scopus.com/inward/record.url?eid=2-s2.0-10044240740&partnerID=MN8TOARS.
    10.1529/biophysj.104.049353
  37. Victor, BL; Baptista, AM; Soares, CM. "Study of proton channels in the quinol oxidase (aa3) from acidianus ambivalens using theoretical methodologies". Biochimica Et Biophysica Acta-Bioenergetics 1658 (2004): 173-173. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000223500600228&KeyUID=WOS:000223500600228.
  38. Victor, BL; Vicente, JB; Rodrigues, R; Oliveira, S; Rodrigues-Pousada, C; Frazao, C; Gomes, CM; Teixeira, M; Soares, CM. "Docking and electron transfer studies between rubredoxin and rubredoxin : oxygen oxidoreductase". Journal of Biological Inorganic Chemistry 8 4 (2003): 475-488. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000183036300012&KeyUID=WOS:000183036300012.
    10.1007/s00775-002-0440-5
Capítulo de livro
  1. Victor, Bruno. "Identification of Pan Assay INterference compoundS (PAINS) using an MD-Based Protocol". In Computational Design of Membrane Proteins, editado por Irina S. Moreira. Estados Unidos: Springer US, 2021.
    No prelo
Poster em conferência
  1. Paulo, Alexandra; Aljnadi, Israa; Bahls, Bárbara; Mendes, Eduarda; Maçôas, Ermelinda Maria Sengo; Victor, Bruno; Russel, Rick. Autor correspondente: Paulo, Alexandra. "New indolo[3,2-c]isoquinolines to target c-MYC G4 – DHX36 helicase interaction". Trabalho apresentado em 9th EuChemS, 2024.
  2. Bahls, Bárbara; Aljnadi, Israa; Emídio, Rita; Victor, Bruno; Cruz, Carla; Figueiredo, Joana; Maçôas, Ermelinda Maria Sengo; Russell, Rick; Paulo, Alexandra. Autor correspondente: Bahls, Bárbara. "Design, synthesis and evaluation of new small molecules to target c-MYC G4-DHX36 helicase interaction". Trabalho apresentado em 20th RSC Nucleic Acids, 2024.
  3. Bahls, Bárbara; Emídio, Rita; Victor, Bruno; Cruz, Carla; Figueiredo, Joana; Paulo, Alexandra. Autor correspondente: Bahls, Bárbara. "c-MYC G-quadruplex stabilization by 5-amino-8-chloro-11H-indolo[3,2-c]isoquinoline derivatives: in vitro and in silico studies.". Trabalho apresentado em 15th ENQO & 8th ENQT, 2024.
  4. Joana V. Ribeiro; Magalhães, Pedro R.; Faustino, Hélio; Pedro M. P. Góis; Victor, Bruno; Cláudio M. Gomes; Henriques, Bárbara J. "Potential regulatory role of succinylation on electron transfer flavoprotein, a key protein in mitochondrial metabolism". Trabalho apresentado em EBSA Congress 2023, 2023.
  5. Farinha, B; Brígido, Ana; Simão, AL; Victor, Bruno; Castro, Rui. "Unveiling the Functional Role of TGR5 in Fat-to-Liver Communication: Discovery of Novel Agonists". Trabalho apresentado em 3rd Chem&BioChem Students Meeting, 2023.
  6. Brígido, Ana; Farinha, B; Simão, AL; Fernandes, DAE; Henrique, Mariana; Costa-Silva, Bruno; Victor, Bruno; Castro, Rui. "Functional role of TGR5 in fat-to-liver communication during non-alcoholic fatty liver disease". Trabalho apresentado em 2nd Meeting of the Portuguese Network on Extracellular Vesicles, 2023.
  7. Farinha, B; Brígido, Ana; Simão, AL; Victor, Bruno; Castro, Rui. "Unveiling Promising TGR5 Agonists for NAFLD Treatment through Structure-Based Virtual Screening". Trabalho apresentado em 14th iMed.ULisboa Meeting, 2023.
  8. Farinha, B; Brígido, Ana; Simão, AL; Victor, Bruno; Castro, Rui. "Structure-based virtual screening campaign identifies novel potential TGR5 agonists for the treatment of obesity-associated NAFLD". Trabalho apresentado em Jornadas Científicas da ULisboa, 2023.
  9. Farinha, B; Simão, AL; Castro, RE; Victor, Bruno. "Structure-based virtual screening campaign identifying new promising TGR5 agonists to treat obesity-associated NAFLD". Trabalho apresentado em LEAPS Meets Life Sciences Conference, 2023.
  10. Emídio, Rita; Paulo, Alexandra; Victor, Bruno. "Molecular docking and synthesis of indoloisoquinoline bioisosters as new cancer therapeutics". Trabalho apresentado em 3D-BioInfo-PT Annual Meeting, 2022.
  11. Neto Vasco; Victor, Bruno; Galamba, N.. Autor correspondente: Galamba, N.. "Probing the Anti-sickling Power of Distinct Drugs in Sickle Cell Disease". Trabalho apresentado em 3D-BioInfo-PT Meeting, 2022.
  12. Joana V. Ribeiro; Magalhães, Pedro R.; Joana F. Ferreira; Faustino, Hélio; Pedro M. P. Góis; Cláudio M. Gomes; Victor, Bruno; Henriques, Bárbara J. "Non-enzymatic succinylation of electron transfer flavoprotein ¿ potential implications on multiple acyl-CoA dehydrogenase deficiency". Trabalho apresentado em SSIEM Annual Symposium 2022, 2022.
  13. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Identification, design and synthesis of novel indoloisoquinolines inhibitors of c-myc:G4-helicase interaction". Trabalho apresentado em 2nd Chem&BioChem - Universidade de Lisboa, 2022.
  14. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Computer-assisted design of insoloisoquinolines as potential new anticancer drugs". Trabalho apresentado em 5MCQUL, 2022.
  15. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Development of c-MYC:G4-helicase interaction inhibitors". Trabalho apresentado em 5th Imed Meeting, 2022.
  16. Bahls, Bárbara; Paulo, Alexandra; Victor, Bruno. "Computer-assisted design of indoloisoquinoline as potential DNAG4-Helicase interaction inhibitors". Trabalho apresentado em 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  17. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. Autor correspondente: Magalhães, Pedro R.. "Identification of membrane PAINS via an optimized computational protocol". Trabalho apresentado em 8th EJIBCE, Coimbra, Portugal, 2021.
  18. Bahls, Bárbara; Victor, Bruno; Paulo, Alexandra. Autor correspondente: Bahls, Bárbara. "Design of Indoloisoquinoline derivatives as potential inhibitors of the interaction between c-MYC:G4 and helicase". Trabalho apresentado em EJIBCE, 2021.
    https://doi.org/10.3390/mol2net-07-12112
  19. Marques, Jéssica; Pimpão, Catarina; Victor, Bruno; Soveral, Graça. "Development of new computational workflow for the identification of hAQP5 modulators". Trabalho apresentado em VIII EJIBCE, 2021.
  20. Aljnadi, I; Magalhães, PR; Victor, Bruno; Paulo, Alexandra. "Computational Screening and Design of G-quadruplex Ligands Targeting c-MYC in Breast Cancer". Trabalho apresentado em The Meeting of Young Investigators in Structural Computational Biology (EJIBCE) 2021, IIIV Edition (Portugal, Coimbra), 2021.
  21. Joana V. Ribeiro; Magalhães, Pedro R.; Joana F. Ferreira; Faustino, Hélio; Pedro M. P. Góis; Cláudio M. Gomes; Victor, Bruno; Henriques, Bárbara J. "Structural impact of succinylation on Electron Transfer Flavoprotein function". Trabalho apresentado em 17th International Symposium of SPDM, 2021.
  22. Aljnadi, I; Magalhães, PR; Victor, Bruno; Paulo, Alexandra. "Binding of (Iso)Quinolinyl-Pyridine-2,6-dicarboxamide ligands to G-quadruplexes: a computational approach". Trabalho apresentado em iMed.Ulisboa Meeting 2021( ipSC),, 2021.
  23. Marques, Jéssica; Pimpão, Catarina; Victor, Bruno; Soveral, G.. "Identification of new human AQP5 inhibitors using computational and experimental approaches". Trabalho apresentado em iMed.ULisboa Meeting 2021, 2021.
  24. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. Autor correspondente: Magalhães, Pedro R.. "Development of a Novel Computational Protocol for the Identification of Membrane PAINS". Trabalho apresentado em Computer Simulation and Theory of Macromolecules, Hunfeld Online Workshop, 2021.
  25. Ferreira, Sara; Victor, Bruno. "Targeting Aquaporin-1 to Identify New Anti-Cancer Therapies". Trabalho apresentado em Hünfeld 2021: Workshop on Computer Simulation and Theory of Macromolecules, 2021.
  26. Marques, Jéssica; Soveral, Graça; Victor, Bruno. "Screening of aquaporin-5 modulators with anticancer properties". Trabalho apresentado em Hünfeld 2021: Workshop on Computer Simulation and Theory of Macromolecules, 2021.
  27. Marques, Jéssica; Pimpão, Catarina; Victor, Bruno; Soveral, Graça. "Identification of new and innovative human AQP5 inhibitors using computational and experimental approaches". Trabalho apresentado em Imed.ULisboa meeting, 2021.
  28. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Speeding-up the identification of membrane PAINS with a new computational approach". Trabalho apresentado em Ciências Research Day, 2020.
  29. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Refining an umbrella-sampling protocol to describe membrane PAINS". Trabalho apresentado em EJIBCE 2019 (7th Encontro de Jovens Investigadores de Biologia Computacional Estrutural), Lisboa, Portugal, 2019.
  30. Magalhães, Pedro R.; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Structural characterization of Aquaporin-1 and evaluation of a PMF based protocol to determine water permeability rates". Trabalho apresentado em EJIBCE 2019 (7th Encontro de Jovens Investigadores de Biologia Estrutural Compucacional), Lisboa, Portugal, 2019.
  31. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Computational Characterization of Membrane PAINS". Trabalho apresentado em Joint 12th EBSA 10th ICBP-IUPAP Biophysics Congress, Madrid, Spain, 2019.
  32. Magalhães, Pedro R.; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Computational prediction of water permeability rates in Aquaporin-1". Trabalho apresentado em Joint 12th EBSA congress 10th ICBP-IUPAP Congress, Madrid, Spain, 2019.
  33. Magalhães, Pedro R.; Reis, Pedro B P S; Vila-Viçosa, Diogo; Machuqueiro, Miguel; Victor, Bruno. "Optimization of a computational protocol to characterize membrane PAINS". Trabalho apresentado em Workshop on Integrative Approaches to Protein Folding & Aggregation, Lisboa, Portugal, 2019.
  34. Silva, Tomás F.D.; Reis, Pedro B P S; Victor, Bruno; Vila-Viçosa, Diogo; Machuqueiro, Miguel. "Evaluating GROMOS force fields without the twin-range cutoff scheme". Trabalho apresentado em Free Energy Calculations from Molecular Simulation: Aplications in Life and Medical Sciences, 2017.
  35. Lopes, Ana; Simões, C. J. V.; Brito, R.M.M.; Dora, D.C.S.; Victor, Bruno; Bruno F. O. Nascimento; Pinho e Melo, T.M.V.D.. "AMILOTERA ¿ Discovery and optmization of novel therapeutic agents against transthyretyn-related amyloid diseases". Trabalho apresentado em Young Researchers Meeting of Computational Structural Biology, Porto, Portugal, 2013.
Pré-impressão
  1. Al-Jnadi, Israa; Bahls, Bárbara; Emídio, Rita; Manocha, Siona; Tousson, Malak; Russell, Sophie; Figueiredo, Joana; et al. "Design, Synthesis and Evaluation of New Inhibitors of DNA G4 Unfolding by DHX36 helicase". 2025. https://doi.org/10.26434/chemrxiv-2025-bj074.
    10.26434/chemrxiv-2025-bj074
Recurso online
  1. Henriques, Bárbara J; Victor, Bruno; Joana Valente Ribeiro. Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) | Rare Disease Day 2023 (Public Outreach Institucional video). 2023. https://www.youtube.com/watch?v=8-2E6l26V8g.
Resumo em conferência
  1. Joana V. Ribeiro; P. R. Magalhães; Joana F Ferreira; Faustino, Hélio; Pedro Góis; Cláudio M. Gomes; Victor, Bruno; Henriques, Bárbara. "Biochemical studies on the effect of non-enzymatic succinylation of electron transfer flavoprotein". Trabalho apresentado em FEBS OPEN BIO, 2022.
    Publicado
  2. Ferreira, Sara; Victor, Bruno. "Improving the druggability of Aquaporin-1 for future drug discovery campaigns". Trabalho apresentado em EJIBCE 2019, Lisbon, 2020.
    Publicado • 10.3390/mol2net-05-06774

Propriedade Intelectual

Patente
  1. Victor, Bruno. 2016. "Genetic markers and treatment of male obesity". Estados Unidos.
  2. Victor, Bruno. 2016. "SMALL MOLECULE TRANSTHYRETIN STABILIZERS AND USES THEREOF". Estados Unidos.
  3. Victor, Bruno. 2016. "2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF". Estados Unidos.

Outros

Outra produção
  1. Optimization of an in silico protocol to characterize membrane PAINS. 2021. Pedro R. Magalhães; Pedro B. P. S. Reis; Diogo Vila-Viçosa; Miguel Machuqueiro; Bruno L. Victor. https://doi.org/10.26434/chemrxiv-2021-t036h.
    10.26434/chemrxiv-2021-t036h
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2018/12/20 Computational campaign to discover novel human 20S proteasome inhibitors MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition, EJIBCE-02
(Coimbra, Portugal)
2018/12/20 The impact of using single atomistic long range cutoff schemes with the GROMOS 54A7 force field. EJIBCE 2018 meeting
(Porto, Portugal)
2017/07/21 Mutations in the katG heme pocket modulate local electrostatics and impair INH activation Colágio da Química - 2017
(Lisboa, Portugal)
2017/07 P. Reis, T. Silva, B. Victor, D. Vila-Viçosa and M. Machuqueiro, “pKa shifts in protein and membrane binding” Free Energy Calculations from Molecular Simulation Workshop
(London, Reino Unido)
2015/11/20 A química computacional no desenvolvimento de novos agentes terapêuticos Encontro Científico NEQ/AAC
(Coimbra, Portugal)
2015/09/25 Predicting affinity in protein-ligand complexes Summer School in Computational Biology
(Coimbra, Portugal)
2014/10/31 A new theoretical approach to study proton channels in the Quinol Oxidase aa3 from Acidianus ambivalens 3rd Portuguese-Spanish Biophysics Congress
(Lisboa, Portugal)
2014/10/15 Proton channels in the quinol oxidase from Acidianus ambivalens SCAN seminars at ITQB-UNL
(Oeiras, Portugal)
2013/12/22 Binding Free Energy calculations of different series of hits to TTR protein EJIBCE 2013
(Lisboa, Portugal)
2010/10/04 Molecular Modeling of hemagglutinin from Influenza Virus INTERBIO - Barcelona Innovation workshops: NanoBiotechnology & IT for life sciences and medicine
(Barcelona, Espanha)
2007/11/26 Molecular modelling of redox proteins involved in the oxygen and nitric oxide metabolism ITQB-UNL
(Oeiras, Portugal)
2001/09/18 Modelação Molecular da interacção de proteínas em Desulfovibrio gigas Apresentação de Tese de Licenciatura - Universidade de Coimbra
(Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/09/01 - Atual Unclothing the dichotomic pH regulation in aquaporin-7 and aquaporin-10.
Orientador de Marta Batista
 PhD in theoretical biochemistry (Doutoramento)
2022/09/01 - Atual A computational study on the impact of adding anionic groups to tyrosine kinase inhibitors
Coorientador
 MsC in computational biology (Mestrado)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2022/09/01 - Atual Probing the Anti-Sickling Power of Distinct Drugs in Sickle Cell Disease
Coorientador
 MsC in biochemistry and biomedicine (Mestrado)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2020/09/01 - Atual Aquaporin inhibitors with anticancer properties - computational screening and functional validation
Orientador
 Biochemistry (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/09/01 - Atual Ligand and structure-based computational drug discovery of innovative Aquaporin modulators
Orientador
 Bioinformática e Biologia Computacional (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/09/01 - Atual Modelação por Homologia da proteína Aquaporin 7
Orientador
 Bioquímica (Licenciatura/Bacharelato)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/09/01 - Atual Estudos computacionais na Aquaporin-3 e a implicação da sua função no envelhecimento humano
Orientador
 Bioquímica (Licenciatura/Bacharelato)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021/06/01 - 2025/05/31 Development of G4 DNA-Helicase Interaction Inhibitors
Coorientador
 Química Farmacêutica e Terapêutica (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/02/01 - 2025/01/31 Towards a framework to unify in silico methods to support decision-making for chemical risk assessments: application in endocrine disruptors
Orientador
 Theoretical Biochemistry (Doutoramento)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2022/09/01 - 2023/12/21 Optimization and synthesis of indoloisoquinoline derivatives as new anticancer therapeutics
Coorientador
 PhD in medicinal chemistry and biopharmaceutics (Mestrado)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2022/09/01 - 2023/12/20 Structural characterization and identification of novel inhibitors of respiratory proteins from human bacterial pathogens
Orientador
 MsC in Bioorganic Chemistry (Mestrado)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2022/09/01 - 2023/11/16 Structural Characterization and Functional Role of TGR5 in Adipose Tissue – Liver Axis in the context of Non-Alcoholic Fatty Liver Disease
Coorientador
 MsC in biopharmaceutical sciences (Mestrado)
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2021/09/01 - 2022/08/31 Improved drug discovery: towards an energy-based criterion to characterize protein-ligand interactions
Coorientador
 Biochemistry | Medical Biochemistry (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021/09/01 - 2022/08/31 Development of a new hybrid therapeutic agent against malaria by targeting the Aquaglyceroporin from plasmodium spp
Orientador
 Bioinformatics and Computational Biology (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021/09/01 - 2022/08/31 Computer-assisted design and synthesis of DNA-G4/helicase interaction inhibitors
Coorientador
 Química Medicinal e Biofarmacêutica (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/03/01 - 2018/06/30 Structural characterization of Aquaporin-4 using Molecular Dynamics simulations
Coorientador
 iMED PhD program (Doutoramento)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/09/01 - 2016/05/04 Modelação molecular/bioinformática estrutural da hemaglutinina do Virús Influenza
Coorientador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/09/01 - 2016/01/11 Em busca de determinantes estruturais no reconhecimneto e ligação de amilóide: beta-2 microglobulina como caso de estudo
Coorientador
 Química Terapêutica (Mestrado)
Universidade de Coimbra, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/12/20 - 2019/12/20 EJIBCE 2019 (2019/12/20 - 2019/12/20)
Conferência (Membro da Comissão Organizadora)
2015/12/22 - 2015/12/22 Organização do EJIBCE 2015 (2015/12/22 - 2015/12/22)
Conferência (Membro da Comissão Organizadora)
2008/07/04 - 2008/07/06 Organizing Committee of the 1st Portuguese-Spanish-British Joint Biophysics Congress (2008/07/04 - 2008/07/04)
Conferência (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Unidade de Ensino e Investigação em Saúde Pública Internacional e Bioestatística, Portugal
2007/10/01 - 2007/10/01 Organizing Committee of the 7h Short Course of the Portuguese Biophysical Society “Biospectroscopy and Imaging” (2007/10/01 - 2007/10/01)
Congresso (Membro da Comissão Organizadora)
 Instituto Politécnico de Santarém, Portugal
2005/10/01 - 2005/10/01 Organizing Committee of the 6th Short Course of the Portuguese Biophysical Society “From Membrane Transport to Neurosciences: a Biophysical Perspective” (2005/10/01 - 2005/10/01)
Conferência (Membro da Comissão Organizadora)
 Instituto Politécnico de Santarém, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2019/12/20 - Atual Pedro R. Magalhães, Diogo Vila-Viçosa, Miguel M. Machuqueiro, Bruno L. Victor "Structural characterization of Aquaporin-1 and evaluation of a PMF based protocol to determine water permeability rates", Poster Presentation
Congresso
 EJIBCE 2019
2019/12/20 - Atual Sara Ferreira, Bruno L. Victor "Combined ligand and structure-based computational drug discovery of innovative Aquaporin modulators", Poster Presentation
Congresso
 EJIBCE 2019
2019/12/20 - Atual Pedro Magalhães, Pedro Reis, Diogo Vila-Viçosa, Miguel Machuqueiro, Bruno L. Victor "Refining an umbrella-sampling protocol to describe membrane PAINS", Poster presentation
Congresso
 EJIBCE 2019
2019/07/20 - Atual Pedro R. Magalhães, Diogo Vila-Viçosa, Miguel M. Machuqueiro, Bruno L. Victor, "Evaluation of different computational approaches to measure water permeabilities in Aquaporins", Poster Presentation Joint 12th EBSA-10th ICBP-IUPAP Biophysics Congress
2019/07/20 - Atual Pedro R. Magalhães, Pedro B. P. S. Reis, Diogo Vila-Viçosa, Miguel Machuqueiro, Bruno L. Victor, "Pedro R. Magalhães, Pedro B. P. S. Reis, Diogo Vila-Viçosa, Miguel Machuqueiro, Bruno L. Victor", Poster presentation
Congresso
 Joint 12th EBSA-10th ICBP-IUPAP Biophysics Congress
2019/07/19 - Atual Pedro R. Magalhães, Pedro B.P.S. Reis, Diogo Vila-Viçosa, Miguel Machuqueiro, Bruno L. Victor "Optimization of a computational protocol to characterize membrane PAINS", Poster Presentation INTEGRATIVE APPROACHES TO PROTEIN FOLDING & AGGREGATION
2019/07/11 - Atual Pedro Magalhães , Diogo Vila-Viçosa , Miguel Machuqueiro , Bruno L. Victor "Computational prediction of water permeability rates in Aquaporin-1"
Congresso
 Workshop on Integrative approaches to protein folding and aggregation
2017/05 - Atual T. Silva, P. Reis, B. L. Victor, D. Vila-Viçosa and M. Machuqueiro, “Evaluating GROMOS force fields without the twin-range cutoff scheme”
Congresso
 Free Energy Calculations from Molecular Simulation Workshop
2017/05 - Atual B. L. Victor, D. Vila-Viçosa, F. Martins, P. Loewen, M. Machuqueiro, “KatG S315 mutations modulate local electrostatics impairing INH activation”
Congresso
 Free Energy Calculations from Molecular Simulation Workshop
2016/12 - Atual B. L. Victor, D. Vila-Viçosa, P. Loewen, M. Machuqueiro, “pKa calculations in the heme pocket of KatG during its catalytic cycle”
Congresso
 EJIBCE 2016
2015/12/18 - Atual Pedro Fernandes, Bruno L. Victor, Cândida Silva, Rui Brito, "Characterization of the ß2m-ThT complex using molecular dynamics and alchemical free energy calculations
Congresso
 EJIBCE 2015
2015/12/01 - Atual Pedro M. P. Fernandes, Bruno L. Victor, Candida G. Silva, Rui M.M. Brito, 2015, Application of Molecular Dynamics and Alchemical Free Energy Calculations to study the interaction of ß-2 microglobulin with thioflavin-T
Congresso
 Congresso Química Orgânica e Química Terapêutica
2015/06/10 - Atual Pedro M. P. Fernandes, Bruno L. Victor, Candida G. Silva, Rui M. M. Brito, 2015, Searching for structural determinants in amyloid recognition and binding
Congresso
 6th European Conference Chemistry in the Life Sciences
2014/12/19 - Atual Pedro M. P. Fernandes, Bruno L. Victor, Cândida G. Silva, Rui M.M. Brito "Searching for structural determinants in amyloid recognition and binding"
Congresso
 Second Portuguese Young Researchers in Computational Structural Biology Meeting
2014/12/17 - Atual Pedro M. P. Fernandes, Bruno L. Victor, Cândida G. Silva, Rui M.M. Brito (2014) Molecular docking and molecular dynamics studies of the interaction of ThT with ß2-microglobulin
Conferência
 XVIII Congress of the Portuguese Biochemichal Society
Universidade de Coimbra, Portugal
2014/06/16 - Atual Pedro M. P. Fernandes, Bruno L. Victor, Cândida G. Silva, Rui M.M. Brito (2014) Molecular docking and molecular dynamics studies of the interaction of ThT with ß2-microglobulin
Congresso
 Coimbra Chemistry Centre Day
Universidade de Coimbra, Portugal
2009/11/23 - Atual Victor BL, Baptista AM, Soares CM, "Interaction studies of the fusion peptide of Hemagglutinin H3 with DMPC and DMPG membrane bilayers – a molecular modelling approach"
Congresso
 Expanding the frontiers of molecular dynamics simulations in biology
2008/09/22 - Atual Victor, BL, Baptista AM, Soares, CM "Dioxygen and Nitric Oxide affinity and pathways to the catalytic site of Rubreoxin:Oxygen Oxidoreductase from Desulfovibrio gigas"
Congresso
 ECCB08 – European Conference on Computational Biology
2008 - Atual Victor, BL, Baptista AM, Soares, CM "Dioxygen and Nitric Oxide affinity and pathways to the catalytic site of Rubredoxin:Oxygen Oxidoreductase from Desulfovibrio gigas"
Congresso
 First Portuguese-Spanish-British Biophysical Congress
2007/05/16 - Atual Victor, BL, Baptista AM, Soares, CM “Rubredoxin:Oxygen OxidoReductase from Desulfovibrio gigas: Molecular Dynamics Diffusion Simulations with Dioxygen and Nitric Oxide”. Poster presentation FEBS WORKSHOP ON Trends in Transient Interactions between Biological Macromolecules
2006/09/17 - Atual Victor, BL, Baptista AM, Soares, CM “Study of proton channels found in the Quinol Oxidase aa3 from Acidianus ambivalens using molecular modeling methodologies”. Poster presentation MGMS conference - Quantum Pharmacology - 30 years on, A Special Conference in Honour of Prof. W. Graham Richards
2005/09/11 - Atual Teixeira, V. H., Cunha, C. A., Machuqueiro, M., Oliveira, A. S. F., Victor, B. L., Soares, C. M., Baptista, A. M. (2005) "On the use of different dielectric constants for computing individual and pairwise terms in Poisson-Boltzmann studies of protein ionization equilibrium". Poster presentation
Congresso
 MGMS 2005: Biomolecular Simulations - From Prediction to Practice
2005/08/27 - Atual Victor, BL, Baptista AM, Soares, CM “A new theoretical approach to study proton channels in the Quinol Oxidase aa3 from Acidianus ambivalens”, Poster presentation
Congresso
 15th IUPAB and 5th EBSA Biophysics Congress
2004/12/02 - Atual Victor, BL, Baptista AM, Soares, CM (2004) “Theoretical study of proton channels in the Quinol Oxidase aa3 from Acidianus ambivalens”, Poster Presentation
Congresso
 XIV Congresso Nacional de Bioquímica
2004/08/21 - Atual Victor, BL, Baptista AM, Soares, CM “Study of proton channels in the quinol oxidase (aa3) from Acidianus ambivalens using theoretical methodologies”. Poster presentation
Congresso
 13th European Bioenergetics Conference – EBEC
2003/08/26 - Atual Victor, BL, Vicente, JB, Rodrigues, R, Oliveira, S, Rodrigues-Pousada, C, Frazão, C, Gomes, CM, Teixeira, M, Soares, CM “Rubredoxin and rubredoxin:oxygen oxidoreductase: two interacting proteins in a soluble electron transfer chain”. Poster presentation
Congresso
 56th Harden Conference “Biological electron and proton transfer”
2002/12 - Atual Victor, BL, Vicente, J, Rodrigues, R, Oliveira, S, Rodrigues-Pousada, C, Frazão, C, Gomes, CM, Teixeira, M, Soares, CM "Modelling the interactions and the electron transfer of rubredoxin and rubredoxin:oxgen oxidoreductase". Poster presentation
Congresso
 XIII Congresso Nacional de Bioquímica
2002/09 - Atual Victor, BL Vicente, JB, Rodrigues, R, Oliveira, S, Rodrigues-Pousada, C, Frazão, C, Gomes, CM, Teixeira, M, Soares, CM (2002) "Interaction studies between rubredoxin (Rd) and rubredoxin-oxygen oxido reductase (ROO)". Poster presentation
Congresso
 ESF conference in Computational biophysics: integrating theoretical physics and biology

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019/01/01 - Atual Pharmaceuticals (1424-8247) MDPI AG
2017/01 - Atual Bioengeneering
2017/01 - Atual Scientia Pharmaceutica (2218-0532) MDPI AG
2017/01 - Atual PLoS ONE (1932-6203) Public Library of Science
2016/01/01 - Atual BioMed Research International (2314-6141) Hindawi Limited
2016/01/01 - Atual Journal of Molecular Structure (0022-2860) Elsevier
2016/01 - Atual Molecules (1420-3049) MDPI AG
2015/01/01 - Atual Membranes (2077-0375) MDPI AG
2013/01/01 - Atual International Journal of Computational and Theoretical Chemistry (2376-7286) Science Publishing Group
2013/01/01 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2013/01/01 - Atual JBIC Journal of Biological Inorganic Chemistry (1432-1327) Springer-Verlag

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/02/01 - 2021/06/30 Biochemical Simulation Bioquímica (Licenciatura) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2004/09 - 2012/06 Theoretical and practical teaching classes in Molecular Visualization, Molecular Docking, Protein Homology Modelling and Molecular Mechanics integrated in the PhD Program of ITQB-UNL and Instituto Gulbenkian da Ciência (Doutoramento) Instituto Gulbenkian de Ciência, Portugal
2008/09 - 2009/02 Biochemistry classes for the Biochemical engineering diploma course at Lusofona University Biochemical engineering (Licenciatura) Universidade Lusófona Associação para a Investigação e Desenvolvimento em Cognição e Computação Centrado nas Pessoas, Portugal

Membro de associação

Nome da associação Tipo de participação
2009/01/01 - 2012/10/30 Portuguese Biochemical Society Member of the Directive Board of the
2003/01/01 - 2008/12/31 Portuguese Biophysical Society Second Secretary of the General Assembly