Artigo em revista |
- Ana Vasconcelos-Ferreira; Sara Carmo-Silva; José Miguel Codêsso; Patrick Silva; Alberto Rolim Muro Martinez; Marcondes Cavalcante
França Jr; Clévio Nóbrega; et al. "The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment
in mouse models of Machado–Joseph disease". Neuropathology and Applied Neurobiology (2022): https://doi.org/10.1111/nan.12763.
10.1111/nan.12763
- Holger Hengel; Peter Martus; Jennifer Faber; Hector Garcia-Moreno; Nita Solanky; Paola Giunti; Thomas Klockgether; et al.
"Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity". Movement Disorders
(2022): https://doi.org/10.1002/mds.28844.
10.1002/mds.28844
- Ana Teresa Simões; Vítor Carmona; Joana Duarte-Neves; Janete Cunha-Santos; Luís Pereira de Almeida. "Identification of the
calpain-generated toxic fragment of ataxin-3 protein provides new avenues for therapy of Machado–Joseph disease| Spinocerebellar
ataxia type 3". Neuropathology and Applied Neurobiology (2022): https://doi.org/10.1111/nan.12748.
10.1111/nan.12748
- Vasconcelos-Ferreira, A.; Martins, I.M.; Lobo, D.; Pereira, D.; Lopes, M.M.; Faro, R.; Lopes, S.M.; et al. "ULK overexpression
mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease". Molecular Therapy 30 1 (2022):
370-387. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115030983&partnerID=MN8TOARS.
10.1016/j.ymthe.2021.07.012
- Rufino-Ramos, D.; Lule, S.; Mahjoum, S.; Ughetto, S.; Cristopher Bragg, D.; Pereira de Almeida, L.; Breakefield, X.O.; Breyne,
K.. "Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo". Biomaterials
281 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85122652441&partnerID=MN8TOARS.
10.1016/j.biomaterials.2022.121366
- Ana S. Neto; Patrícia Pereira; Ana C. Fonseca; Carla Dias; Mariana C. Almeida; Inês Barros; Catarina O. Miranda; et al. "Highly
Porous Composite Scaffolds Endowed with Antibacterial Activity for Multifunctional Grafts in Bone Repair". Polymers
(2021): https://doi.org/10.3390/polym13244378.
10.3390/polym13244378
- Shadi Mahjoum; David Rufino-Ramos; Luís Pereira de Almeida; Marike L. D. Broekman; Xandra O. Breakefield; Thomas S. van Solinge;
Mahjoum, Shadi; et al. "Living Proof of Activity of Extracellular Vesicles in the Central Nervous System". International
Journal of Molecular Sciences 22 14 (2021): 7294-7294. https://doi.org/10.3390/ijms22147294.
10.3390/ijms22147294
- Barros, I.; Silva, A.; de Almeida, L.P.; Miranda, C.O.. "Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of
a pleiotropic therapy". Cytokine and Growth Factor Reviews (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85098642605&partnerID=MN8TOARS.
10.1016/j.cytogfr.2020.12.002
- Duarte-Neves, J.; Cavadas, C.; Pereira de Almeida, L.. "Neuropeptide Y (NPY) intranasal delivery alleviates Machado–Joseph
disease". Scientific Reports 11 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85100703911&partnerID=MN8TOARS.
10.1038/s41598-021-82339-5
- Klionsky, D.J.; Abdel-Aziz, A.K.; Abdelfatah, S.; Abdellatif, M.; Abdoli, A.; Abel, S.; Abeliovich, H.; et al. "Guidelines
for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102619204&partnerID=MN8TOARS.
10.1080/15548627.2020.1797280
- Hübener-Schmid, J.; Kuhlbrodt, K.; Peladan, J.; Faber, J.; Santana, M.M.; Hengel, H.; Jacobi, H.; et al. "Polyglutamine-Expanded
Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood". Movement Disorders (2021):
http://www.scopus.com/inward/record.url?eid=2-s2.0-85113149446&partnerID=MN8TOARS.
10.1002/mds.28749
- Marcelo, A.; Afonso, I.T.; Afonso-Reis, R.; Brito, D.V.C.; Costa, R.G.; Rosa, A.; Alves-Cruzeiro, J.; et al. "Autophagy in
Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy". Cell Death and Disease 12 12 (2021):
8-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-85120082938&partnerID=MN8TOARS.
10.1038/s41419-021-04404-1
- Walter, J.; Bolognin, S.; Poovathingal, S.K.; Magni, S.; Gérard, D.; Antony, P.M.A.; Nickels, S.L.; et al. "The Parkinson's-disease-associated
mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1". Cell Reports 37 3 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85117275453&partnerID=MN8TOARS.
10.1016/j.celrep.2021.109864
- Aguiar, S.I.; Dias, J.N.R.; André, A.S.; Silva, M.L.; Martins, D.; Carrapiço, B.; Castanho, M.; et al. "Highly specific blood-brain
barrier transmigrating single-domain antibodies selected by an in vivo phage display screening". Pharmaceutics 13 10
(2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85116780736&partnerID=MN8TOARS.
10.3390/pharmaceutics13101598
- Moreira, R.; Mendonça, L.S.; de Almeida, L.P.. "Extracellular vesicles physiological role and the particular case of disease-spreading
mechanisms in polyglutamine diseases". International Journal of Molecular Sciences 22 22 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85118955937&partnerID=MN8TOARS.
10.3390/ijms222212288
- Marcelo, A.; Koppenol, R.; de Almeida, L.P.; Matos, C.A.; Nóbrega, C.. "Stress granules, RNA-binding proteins and polyglutamine
diseases: too much aggregation?". Cell Death and Disease 12 6 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85107594482&partnerID=MN8TOARS.
10.1038/s41419-021-03873-8
- Diana Duarte Lobo; Rui Jorge Nobre; Catarina Oliveira Miranda; Dina Pereira; João Castelhano; José Sereno; Arnulf Koeppen;
Miguel Castelo-Branco; Luís Pereira de Almeida. "The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar
ataxia type 3: evidence from transgenic mice and human post-mortem samples". Acta Neuropathologica Communications (2020):
https://doi.org/10.1186/s40478-020-00955-0.
10.1186/s40478-020-00955-0
- Laetitia S. Gaspar; Magda M. Santana; Carina Henriques; Maria M. Pinto; Teresa M. Ribeiro-Rodrigues; Henrique Girão; Rui Jorge
Nobre; Luís Pereira de Almeida. "Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles
for Transcriptional Research". Molecular Therapy - Methods & Clinical Development (2020): https://doi.org/10.1016/j.omtm.2020.07.012.
10.1016/j.omtm.2020.07.012
- Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia
S.; Nóbrega, Clévio; et al. "Trehalose alleviates the phenotype of Machado–Joseph disease mouse models". Journal of Translational
Medicine 18 1 (2020): http://dx.doi.org/10.1186/s12967-020-02302-2.
10.1186/s12967-020-02302-2
- Lopes, Sara Monteiro; Faro, Rosário; Lopes, Miguel Monteiro; Onofre, Isabel; Mendonça, Nuno; Ribeiro, Joana; Januário, Cristina;
Nobre, Rui Jorge; Pereira de Almeida, Luís. "Protocol for the Characterization of the CAG Tract and Flanking Polymorphisms
in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies". The Journal of Molecular Diagnostics
(2020): http://dx.doi.org/10.1016/j.jmoldx.2020.03.003.
10.1016/j.jmoldx.2020.03.003
- Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria; Cunha, Pedro; Pereira de
Almeida, Luís; et al. "miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal
Model of Alzheimer’s Disease". Molecular Therapy - Nucleic Acids 19 (2020): 1219-1236. http://dx.doi.org/10.1016/j.omtn.2020.01.010.
10.1016/j.omtn.2020.01.010
- Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas,
Cláudia. "Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria
Syndrome Cells". The Journals of Gerontology: Series A (2020): http://dx.doi.org/10.1093/gerona/glz280.
10.1093/gerona/glz280
- Wilke, C.; Haas, E.; Reetz, K.; Faber, J.; Garcia-Moreno, H.; Santana, M.M.; van de Warrenburg, B.; et al. "Neurofilaments
in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice". EMBO Molecular
Medicine 12 7 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086096828&partnerID=MN8TOARS.
10.15252/emmm.201911803
- Barros, I.; Marcelo, A.; Silva, T.P.; Barata, J.; Rufino-Ramos, D.; Pereira de Almeida, L.; Miranda, C.O.. "Mesenchymal Stromal
Cells’ Therapy for Polyglutamine Disorders: Where Do We Stand and Where Should We Go?". Frontiers in Cellular Neuroscience
14 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85093862610&partnerID=MN8TOARS.
10.3389/fncel.2020.584277
- Lopes, C.; Tang, Y.; Anjo, S.I.; Manadas, B.; Onofre, I.; de Almeida, L.P.; Daley, G.Q.; Schlaeger, T.M.; Rego, A.C.C.. "Mitochondrial
and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting". Frontiers
in Cell and Developmental Biology 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85092059116&partnerID=MN8TOARS.
10.3389/fcell.2020.576592
- Henriques, Daniel; Moreira, Ricardo; Schwamborn, Jens; Pereira de Almeida, Luís; Mendonça, Liliana S.. "Successes and Hurdles
in Stem Cells Application and Production for Brain Transplantation". Frontiers in Neuroscience 13 (2019): http://dx.doi.org/10.3389/fnins.2019.01194.
10.3389/fnins.2019.01194
- Ana C Silva; Diana D Lobo; Inês M Martins; Sara M Lopes; Carina Henriques; Sónia P Duarte; Jean-Cosme Dodart; Rui Jorge Nobre;
Luis Pereira de Almeida. "Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine
disorders". Brain (2019): https://doi.org/10.1093/brain/awz328.
10.1093/brain/awz328
- Almeida, Luis. "RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding
Short Hairpin RNAs Targeting Mutant Ataxin-3.". Human gene therapy (2019): https://doi.org/10.1089/hum.2018.157.
10.1089/hum.2018.157
- Liliana S Mendonça; Clévio Nóbrega; Silvia Tavino; Maximilian Brinkhaus; Carlos Matos; Sandra Tomé; Ricardo Moreira; et al.
"Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination
in Machado-Joseph disease models". Human Molecular Genetics (2019): https://doi.org/10.1093/hmg/ddz097.
10.1093/hmg/ddz097
- Almeida, Luis. "Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality.".
Stem cell reports (2019): http://europepmc.org/articles/PMC6522948.
10.1016/j.stemcr.2019.03.004
- Nóbrega, Clévio; Codesso, Jose Miguel; Mendonca, Liliana; de Almeida, Luis Pereira. "RNA interference therapy for Machado-Joseph
disease: Long-term safety profile of lentiviral vectors encoding short hairpin RNAs targeting mutant ataxin-3". (2019): http://hdl.handle.net/10400.1/14340.
10.1089/hum.2018.157
- Marcelo, Adriana; Brito, Filipa; Carmo-Silva, Sara; Matos, Carlos A.; Alves-Cruzeiro, Joao; Vasconcelos-Ferreira, Ana; Koppenol,
Rebekah; et al. "Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado-Joseph disease
models". Human molecular genetics 28 1 (2019): 51-63. http://hdl.handle.net/10400.1/14482.
10.1093/hmg/ddy328
- Nóbrega, Clévio; Mendonca, Liliana; Marcelo, Adriana; Lamaziere, Antonin; Tome, Sandra; Despres, Gaetan; Matos, Carlos A;
et al. "Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar
ataxia". Acta Neuropathologica (2019): http://hdl.handle.net/10400.1/14197.
10.1007/s00401-019-02019-7
- Rodrigues, C.F.D.; Serrano, E.; Patrício, M.I.; Val, M.M.; Albuquerque, P.; Fonseca, J.; Gomes, C.M.F.; et al. "Stroma-derived
IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells". Scientific Reports
8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85050990420&partnerID=MN8TOARS.
10.1038/s41598-018-29947-w
- Marques, A.P.; Cunha-Santos, J.; Leal, H.; Sousa-Ferreira, L.; Pereira de Almeida, L.; Cavadas, C.; Rosmaninho-Salgado, J..
"Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice". Biochimica et Biophysica
Acta - General Subjects 1862 3 (2018): 403-413. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037668547&partnerID=MN8TOARS.
10.1016/j.bbagen.2017.11.012
- Pólvora-Brandão, D.; Joaquim, M.; Godinho, I.; Aprile, D.; Álvaro, A.R.; Onofre, I.; Raposo, A.C.; et al. "Loss of hierarchical
imprinting regulation at the Prader-Willi/Angelman syndrome locus in human iPSCs". Human molecular genetics 27 23 (2018):
3999-4011. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056694837&partnerID=MN8TOARS.
10.1093/hmg/ddy274
- Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al. "Repeated
Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS.
10.1016/j.ymthe.2018.07.007
- Gonçalves, N.; Simões, A.T.; Prediger, R.D.; Hirai, H.; Cunha, R.A.; Pereira de Almeida, L.. "Caffeine alleviates progressive
motor deficits in a transgenic mouse model of spinocerebellar ataxia". Annals of Neurology 81 3 (2017): 407-418. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013441188&partnerID=MN8TOARS.
10.1002/ana.24867
- Rufino-Ramos, D.; Albuquerque, P.R.; Carmona, V.; Perfeito, R.; Nobre, R.J.; Pereira de Almeida, L.. "Extracellular vesicles:
Novel promising delivery systems for therapy of brain diseases". Journal of Controlled Release 262 (2017): 247-258.
http://www.scopus.com/inward/record.url?eid=2-s2.0-85026758579&partnerID=MN8TOARS.
10.1016/j.jconrel.2017.07.001
- Cristo, F.; Inácio, J.M.; Rosas, G.; Carreira, I.M.; Melo, J.B.; de Almeida, L.P.; Mendes, P.; et al. "Generation of human
iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alteration".
Stem Cell Research 25 (2017): 152-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033403571&partnerID=MN8TOARS.
10.1016/j.scr.2017.10.019
- Hachigian, L.J.; Carmona, V.; Fenster, R.J.; Kulicke, R.; Heilbut, A.; Sittler, A.; Pereira de Almeida, L.; et al. "Control
of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2". Cell Reports 21
10 (2017): 2688-2695. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038085324&partnerID=MN8TOARS.
10.1016/j.celrep.2017.11.018
- Matos, C.A.; de Almeida, L.P.; Nóbrega, C.. "Proteolytic cleavage of polyglutamine disease-causing proteins: Revisiting the
toxic fragment hypothesis". Current Pharmaceutical Design 23 5 (2017): 753-775. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017122161&partnerID=MN8TOARS.
10.2174/1381612822666161227121912
|