???global.info.a_carregar???
Miguel Prudêncio graduated in Biochemistry by the Faculty of Sciences of the University of Lisbon in 1993 and completed his PhD on Biochemistry by the University of East Anglia in 2000, followed by a post-doctoral period at the University of Leiden. During this period, he worked on metalloprotein characterization and protein-protein interactions. In 2004, he shifted his research focus to the field of malaria and became a post-doc in Maria Mota¿s research group at Instituto de Medicina Molecular (iMM). In 2008, he became a Staff Scientist of iMM¿s Malaria Unit and, in 2013, he became an independent Group Leader at iMM, heading the Prudêncio lab. He was appointed Invited Associate Professor of the Faculdade de Medicina da Universidade de Lisboa in March 2019, and completed his Habilitation to this Faculty in January 2023. Miguel¿s research interests focus on the investigation of Plasmodium liver stages and on the exploitation of their potential for anti-malarial intervention. He is guided by the conviction that the ambitious goal of malaria eradication requires the combination of the knowledge driven by fundamental investigation with the targeted approaches afforded by translational research. His research program includes unveiling novel aspects of the biology of Plasmodium infection, identifying drugs with antiplasmodial activity, establishing new experimental methodologies to study the malaria parasite, and investigating the reciprocal impact of concurrent infections with Plasmodium and other infectious agents. Among his ambitions is a desire to contribute to the development of a much-needed effective vaccine against malaria, which has led him to investigate the immunology of Plasmodium liver infection, and to develop and clinically validate a novel approach to whole-sporozoite vaccination against malaria. He has led research projects funded by by multiple National and International funding agencies or institutions, including Fundação para a Ciência e Tecnologia, the Bill and Melinda Gates Foundation, the Malaria Vaccine Initiative, the La Caixa Foundation, Merck KGaA, and the GSK-Tres Cantos Open Lab Foundation. Miguel is the author of over 150 scientific articles in international peer-reviewed journals, with over 6400 citations, an h-index of 42, and an i10 index of 108. He has earned multiple scientific and innovation prizes and awards, and is an inventor of several patents. He regularly lectures at undergraduate and graduate courses in various Faculties and Universities. As the COVID-19 pandemic emerged, Miguel was involved in setting up iMM's Task Force for SARS-CoV-2 diagnostics. He has a keen interest on COVID-19 vaccination and has addressed this issue on multiple occasions in webinars and in the media. https://miguelprudencio.com/ https://imm.medicina.ulisboa.pt/investigation/laboratories/miguel-prudencio-lab/#intro
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Miguel Prudêncio

Nomes de citação

  • Prudêncio, Miguel

Identificadores de autor

Ciência ID
5511-16ED-48E0
ORCID iD
0000-0003-1746-6029
Google Scholar ID
https://scholar.google.pt/citations?user=zduN6wsAAAAJ&hl=pt-PT&oi=ao
Scopus Author Id
6603561872

Endereços de correio eletrónico

  • mprudencio@medicina.ulisboa.pt (Profissional)
  • miguel_prudencio@hotmail.com (Pessoal)

Telefones

Telefone
  • 217999513 (Profissional)

Moradas

  • Instituto de Medicina Molecular, Av. Prof. Egas Moniz - Edf. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas
  • Ciências Naturais - Ciências Biológicas - Microbiologia
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas
  • Ciências Médicas e da Saúde - Ciências da Saúde - Parasitologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português (Idioma materno)
Francês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador elementar (A2) Utilizador elementar (A1) Utilizador proficiente (C1) Utilizador independente (B1)
Formação
Grau Classificação
1996/09/02 - 2000/07/13
Concluído
 Biochemistry (Doctor)
University of East Anglia, Reino Unido
1989/09/09 - 1993/06/24
Concluído
 Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/07/01 - Atual Investigador principal (carreira) (Investigação) Instituto de Medicina Molecular, Portugal
2008/07/01 - 2013/06/30 Investigador Auxiliar (carreira) (Investigação) Instituto de Medicina Molecular, Portugal
2005/01/01 - 2008/06/30 Pós-doutorado (Investigação) Instituto de Medicina Molecular, Portugal
2004/08/01 - 2004/12/31 Pós-doutorado (Investigação) Instituto Gulbenkian de Ciência, Portugal
2000/08/01 - 2004/06/01 Pós-doutorado (Investigação) Universiteit Leiden, Países Baixos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/03/01 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
2019/10/01 - 2020/09/30 Professor Auxiliar Convidado (Docente Universitário) Stritch School of Medicine of Loyola University of Chicago, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2021/11/01 - 2024/10/31 Whole-organism vaccines against P. falciparum and P. vivax malaria with enhanced efficacy and scope
HR21-848
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Caixa d'Estalvis i Pensions de Barcelona
Em curso

Projeto

Designação Financiadores
2019/12/15 - Atual Generation, characterization and in vivo evaluation of a novel live malaria vaccine
TCOLF/2019
Investigador responsável
Instituto de Medicina Molecular, Portugal
 GSK Tres Cantos Open Lab Foundation
Em curso
2018 - 2021 A multitarget strategy to hit all stages of the Plasmodium life-cycle
PTDC_MED-QUI_30021_2017
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 Enabling strategies for enhanced whole-sporozoite malaria vaccines
02/SAICT72017
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
2017 - 2019 Production and maintenance of Plasmodium-infected mosquitoes
Pf
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Merck Biopharma Deutschland
Em curso
2014/06 - 2019 Improving whole organism vaccines against malaria by genetic modification
PTDCMHC-CED26952014
Investigador
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017 - 2018 A P. berghei-based vaccine against Malaria
PbVac-II
Investigador responsável
Instituto de Medicina Molecular, Portugal
 PATH Malaria Vaccine Initiative
Concluído
2016 - 2018 3D hepatic cell models of Plasmodium infection
3DHep
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Merck Biopharma Deutschland
Concluído
2013 - 2018 A New Whole-Organism Vaccine Against Malaria
OPP1025364
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Bill and Melinda Gates Foundation
Concluído
2015 - 2017 A P. berghei-based vaccine against Malaria
PbVac
Investigador responsável
Instituto de Medicina Molecular, Portugal
 PATH Malaria Vaccine Initiative
Concluído
2012/03/01 - 2015/08/31 Towards malaria eradication. A novel approach for multi-targeting the parasite´s life cycle
info:eu-repo/grantAgreement/FCT/3599-PPCDT/118459/PT
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2012/01/01 - 2015/06/30 Utilization of host cell resources by the malaria parasite in the liver
info:eu-repo/grantAgreement/FCT/3599-PPCDT/117060/PT
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/04/01 - 2013/09/30 New drugs for treating and eradicating malaria
info:eu-repo/grantAgreement/FCT/3599-PPCDT/110357/PT
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/01 - 2013/07/31 The influence of bile acids on malaria liver infection
info:eu-repo/grantAgreement/FCT/3599-PPCDT/99118/PT
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2013 A New Whole-Organism Vaccine Against Malaria
OPP1025364
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Bill and Melinda Gates Foundation
Concluído
2008/03/01 - 2011/12/31 The role of SR-BI in malaria infection
info:eu-repo/grantAgreement/FCT/3599-PPCDT/71920/PT
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Sulik, Michal; Fontinha, Diana; Steverding, Dietmar; Sobczak, Szymon; Antoszczak, Michal; Prudêncio, Miguel; Huczynski, Adam. "Unexpected rearrangement of ivermectin in the synthesis of new derivatives with trypanocidal and antiplasmodial activities". European Journal of Medicinal Chemistry 263 (2024): 115951. http://dx.doi.org/10.1016/j.ejmech.2023.115951.
    10.1016/j.ejmech.2023.115951
  2. Fraga, Ana; Mósca, Andreia F.; Moita, Diana; Simas, J. Pedro; Nunes-Cabaço, Helena; Prudêncio, Miguel. "SARS-CoV-2 decreases malaria severity in co-infected rodent models". Frontiers in Cellular and Infection Microbiology 13 (2023): http://dx.doi.org/10.3389/fcimb.2023.1307553.
    10.3389/fcimb.2023.1307553
  3. Moita, Diana; Nunes-Cabaço, Helena; Rôla, Catarina; Franke-Fayard, Blandine; Janse, Chris J.; Mendes, António M.; Prudêncio, Miguel. "Variable long-term protection by radiation-, chemo-, and genetically-attenuated Plasmodium berghei sporozoite vaccines". Vaccine 41 51 (2023): 7618-7625. http://dx.doi.org/10.1016/j.vaccine.2023.11.023.
    10.1016/j.vaccine.2023.11.023
  4. Diana Moita; Catarina Rôla; Helena Nunes-Cabaço; Gonçalo Nogueira; Teresa G. Maia; Ahmad Syibli Othman; Blandine Franke-Fayard; et al. "The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria". npj Vaccines (2023): https://doi.org/10.1038/s41541-023-00778-9.
    10.1038/s41541-023-00778-9
  5. Marinovic, Marina; Rimac, Hrvoje; de Carvalho, Lais Pessanha; Rôla, C.; Santana, S.; Pavic, Kristina; Held, Jana; Prudêncio, Miguel; Rajic, Zrinka. "Design, synthesis and antiplasmodial evaluation of new amide-, carbamate-, and ureido-type harmicines". Bioorganic & Medicinal Chemistry 94 (2023): 117468. http://dx.doi.org/10.1016/j.bmc.2023.117468.
    10.1016/j.bmc.2023.117468
  6. Fonte, Mélanie; Fontinha, Diana; Moita, Diana; Caño-Prades, Omar; Avalos-Padilla, Yunuen; Fernàndez-Busquets, Xavier; Prudêncio, Miguel; Gomes, Paula; Teixeira, Cátia. "New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial leads". European Journal of Medicinal Chemistry 258 (2023): 115575. http://dx.doi.org/10.1016/j.ejmech.2023.115575.
    10.1016/j.ejmech.2023.115575
  7. da Silva, Gustavo; Luz, André F. S.; Duarte, Denise; Fontinha, Diana; Silva, Vera L. M.; Almeida Paz, Filipe A.; Madureira, Ana M.; et al. "Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 Coupling and Domino Cyclization Approach". ChemMedChem 18 17 (2023): http://dx.doi.org/10.1002/cmdc.202300264.
    10.1002/cmdc.202300264
  8. S Mendes, Sofia; Sorg, Moritz; Luís, Cláudia Malta; Fontinha, Diana; Francisco, Denise; Moita, Diana; C Romão, Carlos; et al. "Conjugated carbon monoxide-releasing molecules have broad-spectrum antimicrobial activity". Future Medicinal Chemistry 15 12 (2023): 1037-1048. http://dx.doi.org/10.4155/fmc-2023-0103.
    10.4155/fmc-2023-0103
  9. Joana F. Santos; Raquel Azevedo; Miguel Prudêncio; Fernanda Marques; Yann Le Gal; Dominique Lorcy; Célia Fernandes. "Block Copolymer Micelles Encapsulating Au(III) Bis(Dithiolene) Complexes as Promising Nanostructures with Antiplasmodial Activity". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15031030.
    10.3390/pharmaceutics15031030
  10. Katerina Breiterová; Aneta Ritomská; Diana Fontinha; Jana Kroustková; Daniela Suchánková; Anna Hostalkova; Marcela Šafratová; et al. "Derivatives of Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Hepatic Stage of Plasmodium berghei Infection In Vitro". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/3/1007.
    10.3390/pharmaceutics15031007
  11. Maria João Oliveira; Soraia Caetano; Ana Dalot; Filipe Sabino; Tomás R. Calmeiro; Elvira Fortunato; Rodrigo Martins; et al. "A simple polystyrene microfluidic device for sensitive and accurate SERS-based detection of infection by malaria parasites". The Analyst (2023): https://doi.org/10.1039/D3AN00971H.
    10.1039/D3AN00971H
  12. Moita, Diana; Maia, Teresa G.; Duarte, Miguel; Andrade, Carolina M.; Albuquerque, Inês S.; Dwivedi, Ankit; Silva, Joana C.; et al. "A genetically modified Plasmodium berghei parasite as a surrogate for whole-sporozoite vaccination against P. vivax malaria". npj Vaccines 7 1 (2022): http://dx.doi.org/10.1038/s41541-022-00585-8.
    10.1038/s41541-022-00585-8
  13. Franke-Fayard, Blandine; Marin-Mogollon, Catherin; Geurten, Fiona J. A.; Chevalley-Maurel, Séverine; Ramesar, Jai; Kroeze, Hans; Baalbergen, Els; et al. "Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver". npj Vaccines 7 1 (2022): http://dx.doi.org/10.1038/s41541-022-00558-x.
    10.1038/s41541-022-00558-x
  14. Bouzón-Arnáiz, Inés; Avalos-Padilla, Yunuen; Biosca, Arnau; Caño-Prades, Omar; Román-Álamo, Lucía; Valle, Javier; Andreu, David; et al. "The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures". BMC Biology 20 1 (2022): http://dx.doi.org/10.1186/s12915-022-01374-4.
    10.1186/s12915-022-01374-4
  15. Alves, Américo J. S.; Alves, Nuno G.; Bártolo, Inês; Fontinha, Diana; Caetano, Soraia; Prudêncio, Miguel; Taveira, Nuno; Pinho e Melo, Teresa M. V. D.. "Unveiling a family of spiro-ß-lactams with anti-HIV and antiplasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates". Frontiers in Chemistry 10 (2022): http://dx.doi.org/10.3389/fchem.2022.1017250.
    10.3389/fchem.2022.1017250
  16. Nunes-Cabaço, Helena; Moita, Diana; Prudêncio, Miguel. "Five decades of clinical assessment of whole-sporozoite malaria vaccines". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.977472.
    10.3389/fimmu.2022.977472
  17. Poje, Goran; Pessanha de Carvalho, Lais; Held, Jana; Moita, Diana; Prudêncio, Miguel; Perkovic, Ivana; Tandaric, Tana; Vianello, Robert; Rajic, Zrinka. "Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents". European Journal of Medicinal Chemistry 238 (2022): 114408. http://dx.doi.org/10.1016/j.ejmech.2022.114408.
    10.1016/j.ejmech.2022.114408
  18. Yann Le Gal; Agathe Filatre-Furcate; Dominique Lorcy; Olivier Jeannin; Thierry Roisnel; Vincent Dorcet; Diana Fontinha; et al. "Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes". International Journal of Molecular Sciences 23 13 (2022): 7146-7146. https://doi.org/10.3390/ijms23137146.
    10.3390/ijms23137146
  19. Caroline De Souza Pereira; Helenita Quadros; Sammy Yaw Aboagye; Diana Fontinha; Sarah D'Alessandro; Margaret Elizabeth Byrne; mathieu gendrot; et al. "A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis". Pharmaceutics 14 6 (2022): 1251. https://www.mdpi.com/1999-4923/14/6/1251.
    10.3390/pharmaceutics14061251
  20. Elizabeth A. Lopes; Raquel Mestre; Diana Fontinha; Jenny Legac; Jinxin V. Pei; Margarida Sanches-Vaz; Mattia Mori; et al. "Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity". European Journal of Medicinal Chemistry (2022): https://doi.org/10.1016/j.ejmech.2022.114324.
    10.1016/j.ejmech.2022.114324
  21. Nunes-Cabaço, Helena; Moita, Diana; Rôla, Catarina; Mendes, António M.; Prudêncio, Miguel. "Impact of Dietary Protein Restriction on the Immunogenicity and Efficacy of Whole-Sporozoite Malaria Vaccination". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.869757.
    10.3389/fimmu.2022.869757
  22. Diana Fontinha; Francisca Arez; Isabella Ramella Gal; Gonçalo Nogueira; Diana Moita; Tobias Hyun Ho Baeurle; Catarina Brito; et al. "Pre-erythrocytic Activity of M5717 in Monotherapy and Combination in Preclinical Plasmodium Infection Models". ACS Infectious Diseases 8 4 (2022): 721-727. https://doi.org/10.1021/acsinfecdis.1c00640.
    No prelo • 10.1021/acsinfecdis.1c00640
  23. "The reciprocal influence of the liver and blood stages of the malaria parasite's life cycle". Int. J. Parasitol. (2022):
    Acesso aberto • No prelo
  24. Delphine Jublot; pierre cavailles; Salima Kamche; Denise Francisco; Diana Fontinha; Miguel Prudêncio; Jean-Francois Guichou; et al. "A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti-Toxoplasma and Anti-Plasmodium Activities Controls Acute and Chronic Toxoplasma Infection in Mice". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/6/3254.
    10.3390/ijms23063254
  25. Portugal, Sílvia; Rodriguez, Ana; Prudêncio, Miguel. "Maria M. Mota: Bringing Plasmodium Liver Infection to the Centre Stage of Malaria Research". Frontiers in Cellular and Infection Microbiology 12 (2022): http://dx.doi.org/10.3389/fcimb.2022.851484.
    10.3389/fcimb.2022.851484
  26. Singh, Lovepreet; Fontinha, Diana; Francisco, Denise; Prudêncio, Miguel; Singh, Kamaljit. "Synthesis and antiplasmodial activity of regioisomers and epimers of second-generation dual acting ivermectin hybrids". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-021-04532-w.
    10.1038/s41598-021-04532-w
  27. Charu Upadhyay; Neha Sharma; Sumit Kumar; Prem Prakash Sharma; Diana Fontinha; Bhupender S. Chhikara; Budhaditya Mukherjee; et al. "Synthesis of the new analogs of morpholine and their antiplasmodial evaluation against the human malaria parasite Plasmodium falciparum". New Journal of Chemistry (2022): https://doi.org/10.1039/D1NJ04198C.
    10.1039/D1NJ04198C
  28. Silva, Ana Teresa; Oliveira, Isabel S.; Gomes, Joana; Aguiar, Luísa; Fontinha, Diana; Duarte, Denise; Nogueira, Fátima; et al. "Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine". ChemMedChem (2021): http://dx.doi.org/10.1002/cmdc.202100650.
    10.1002/cmdc.202100650
  29. Araki, Tamasa; Lin, Jing-wen; Prudêncio, Miguel; Cunningham, Deirdre A.; Annoura, Takeshi. "Editorial: Malaria Targeting Toolkit: Host-Parasite Interactions". Frontiers in Cellular and Infection Microbiology 11 (2021): http://dx.doi.org/10.3389/fcimb.2021.795494.
    10.3389/fcimb.2021.795494
  30. Helenita C. Quadros; Aysun Çapci; Lars Herrmann; Sarah D’Alessandro; Diana Fontinha; Raquel Azevedo; Wilmer Villarreal; et al. "Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle". Pharmaceuticals (2021): https://doi.org/10.3390/ph14111129.
    10.3390/ph14111129
  31. Marinovic, Marina; Poje, Goran; Perkovic, Ivana; Fontinha, Diana; Prudêncio, Miguel; Held, Jana; Pessanha de Carvalho, Lais; et al. "Further investigation of harmicines as novel antiplasmodial agents: Synthesis, structure-activity relationship and insight into the mechanism of action". European Journal of Medicinal Chemistry 224 (2021): 113687. http://dx.doi.org/10.1016/j.ejmech.2021.113687.
    10.1016/j.ejmech.2021.113687
  32. Temporão, Adriana; Sanches-Vaz, Margarida; Luís, Rafael; Nunes-Cabaço, Helena; Smith, Terry K.; Prudêncio, Miguel; Figueiredo, Luisa M.. "Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection". PLOS Neglected Tropical Diseases 15 10 (2021): e0009912. http://dx.doi.org/10.1371/journal.pntd.0009912.
    10.1371/journal.pntd.0009912
  33. Alves, Nuno Guerreiro; Bártolo, Inês; Alves, Américo J.S.; Fontinha, Diana; Francisco, Denise; Lopes, Susana M.M.; Soares, Maria I.L.; et al. "Synthesis and structure-activity relationships of new chiral spiro-ß-lactams highly active against HIV-1 and Plasmodium". European Journal of Medicinal Chemistry 219 (2021): 113439. http://dx.doi.org/10.1016/j.ejmech.2021.113439.
    10.1016/j.ejmech.2021.113439
  34. Sharma, Neha; Kashif, Mohammad; Singh, Vigyasa; Fontinha, Diana; Mukherjee, Budhaditya; Kumar, Dhruv; Singh, Shailja; et al. "Novel Antiplasmodial Compounds Leveraged with Multistage Potency against the Parasite Plasmodium falciparum: In Vitro and In Vivo Evaluations and Pharmacokinetic Studies". Journal of Medicinal Chemistry 64 12 (2021): 8666-8683. http://dx.doi.org/10.1021/acs.jmedchem.1c00659.
    10.1021/acs.jmedchem.1c00659
  35. Moita, Diana; Nunes-Cabaço, Helena; Mendes, António M.; Prudêncio, Miguel. "A guide to investigating immune responses elicited by whole-sporozoite pre-erythrocytic vaccines against malaria". The FEBS Journal (2021): http://dx.doi.org/10.1111/febs.16016.
    10.1111/febs.16016
  36. Tavella, Tatyana Almeida; da Silva, Noeli Soares Melo; Spillman, Natalie; Kayano, Ana Carolina Andrade Vitor; Cassiano, Gustavo Capatti; Vasconcelos, Adrielle Ayumi; Camargo, Antônio Pedro; et al. "Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity". ACS Infectious Diseases 7 4 (2021): 759-776. http://dx.doi.org/10.1021/acsinfecdis.0c00454.
    10.1021/acsinfecdis.0c00454
  37. Caroline Souza Pereira; Helenita Costa Quadros; Diogo Rodrigo Magalhaes Moreira; William Castro; Romulo Ivisson Santos De Deus Da Silva; Milena Botelho Pereira Soares; Diana Fontinha; et al. "A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent". ChemMedChem (2021): https://doi.org/10.1002/cmdc.202000653.
    10.1002/cmdc.202000653
  38. Miguel Prudêncio. "Portugal’s prominence in malaria research". EMBO reports (2021): https://doi.org/10.15252/embr.202051692.
    10.15252/embr.202051692
  39. Meireles, Patrícia; Brás, Daniela; Fontinha, Diana; Chora, Ângelo F.; Serre, Karine; Mendes, António M.; Prudêncio, Miguel. "Elimination of Hepatic Rodent Plasmodium Parasites by Amino Acid Supplementation". iScience 23 12 (2020): 101781. http://dx.doi.org/10.1016/j.isci.2020.101781.
    10.1016/j.isci.2020.101781
  40. Prudêncio, Miguel. "In Fairness to Mosquitoes". Trends in Parasitology 36 11 (2020): 876-877. http://dx.doi.org/10.1016/j.pt.2020.08.003.
    10.1016/j.pt.2020.08.003
  41. Marina Marinovic; Ivana Perkovic; Diana Fontinha; Miguel Prudêncio; Jana Held; Lais Pessanha de Carvalho; Tana Tandaric; et al. "Novel Harmicines with Improved Potency against Plasmodium". Molecules (2020): https://doi.org/10.3390/molecules25194376.
    10.3390/molecules25194376
  42. Miguel Prudêncio; Joana C. Costa. "Research funding after COVID-19". Nature Microbiology 5 8 (2020): 986-986. https://doi.org/10.1038/s41564-020-0768-z.
    10.1038/s41564-020-0768-z
  43. Diana Fontinha; Isabel Moules; Miguel Prudêncio. "Repurposing Drugs to Fight Hepatic Malaria Parasites". Molecules (2020): https://doi.org/10.3390/molecules25153409.
    10.3390/molecules25153409
  44. Reuling, Isaie J.; Mendes, Antonio M.; de Jong, Gerdie M.; Fabra-García, Amanda; Nunes-Cabaço, Helena; van Gemert, Geert-Jan; Graumans, Wouter; et al. "An open-label phase 1/2a trial of a genetically modified rodent malaria parasite for immunization against Plasmodium falciparum malaria". Science Tranlsational Medicine 12 eaay2578 (2020):
    Acesso aberto • Publicado
  45. Singh, Lovepreet; Fontinha, Diana; Francisco, Denise; Mendes, Antonio M.; Prudêncio, Miguel; Singh, Kamaljit. "Molecular Design and Synthesis of Ivermectin Hybrids Targeting Hepatic and Erythrocytic Stages of Plasmodium Parasites". Journal of Medicinal Chemistry 63 4 (2020): 1750-1762. http://dx.doi.org/10.1021/acs.jmedchem.0c00033.
    10.1021/acs.jmedchem.0c00033
  46. Perkovic, Ivana; Raic-Malic, Silvana; Fontinha, Diana; Prudêncio, Miguel; Pessanha de Carvalho, Lais; Held, Jana; Tandaric, Tana; et al. "Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits". European Journal of Medicinal Chemistry 187 (2020): 111927. http://dx.doi.org/10.1016/j.ejmech.2019.111927.
    10.1016/j.ejmech.2019.111927
  47. Azevedo, Raquel; Mendes, António M.; Prudêncio, Miguel. "The Impact of Antiretroviral Therapy on Malaria Parasite Transmission". Frontiers in Microbiology 10 (2020): http://dx.doi.org/10.3389/fmicb.2019.03048.
    10.3389/fmicb.2019.03048
  48. Balasubramanian, Lakshmi; Zuzarte-Luís, Vanessa; Syed, Tabish; Mullick, Debakshi; Deb, Saptarathi; Ranga-Prasad, Harish; Meissner, Jana; et al. "Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development". Frontiers in Cellular and Infection Microbiology 9 (2020): http://dx.doi.org/10.3389/fcimb.2019.00451.
    10.3389/fcimb.2019.00451
  49. Sousa, S.A.; Leitão, J.H.; Silva, R.A.L.; Belo, D.; Santos, I.C.; Guerreiro, J.F.; Martins, M.; et al. "On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities". Journal of Inorganic Biochemistry 202 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073982906&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2019.110904
  50. Diana Fontinha; Sílvia A. Sousa; Tânia S. Morais; Miguel Prudêncio; Jorge H. Leitão; Yann Le Gal; Dominique Lorcy; et al. "Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents". Metallomics 12 6 (2020): 974-987. https://doi.org/10.1039/D0MT00064G.
    10.1039/D0MT00064G
  51. Azevedo, Raquel; Mendes, António M.; Prudêncio, Miguel. "Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins". Parasites & Vectors 12 1 (2019): http://dx.doi.org/10.1186/s13071-019-3805-0.
    10.1186/s13071-019-3805-0
  52. Margarida Sanches-Vaz; Christian R. Engwerda; Adriana Temporão; Rafael Luis; Helena Nunes-Cabaço; António M. Mendes; Sarah Goellner; et al. "Trypanosoma brucei infection protects mice against malaria". PLOS Pathogens 15 11 (2019): e1008145-e1008145. https://doi.org/10.1371/journal.ppat.1008145.
    10.1371/journal.ppat.1008145
  53. Américo J. S. Alves; Nuno G. Alves; Cátia C. Caratão; Margarida I. M. Esteves; Diana Fontinha; Inês Bártolo; Maria I. L. Soares; et al. "Spiro-Lactams as Novel Antimicrobial Agents". Current Topics in Medicinal Chemistry (2019): https://doi.org/10.2174/1568026619666191105110049.
    10.2174/1568026619666191105110049
  54. Kamil Wolanin; Diana Fontinha; Margarida Sanches-Vaz; Britta Nyboer; Kirsten Heiss; Ann-Kristin Mueller; Miguel Prudêncio. "A crucial role for the C-terminal domain of exported protein 1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle". Cellular Microbiology 21 10 (2019): https://doi.org/10.1111/cmi.13088.
    10.1111/cmi.13088
  55. Aguiar, Luísa; Machado, Marta; Sanches-Vaz, Margarida; Prudêncio, Miguel; Vale, Nuno; Gomes, Paula; Luísa Aguiar; et al. "Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites". MedChemComm 10 2 (2019): 221-226. http://dx.doi.org/10.1039/c8md00447a.
    10.1039/c8md00447a
  56. Beus, M; Fontinha, D; Held, J; Rajic, Z; Prudencio, M; Zorc, B. "Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides". ACTA PHARMACEUTICA (2019):
    10.2478/acph-2019-0019
  57. Beus, M; Fontinha, D; Held, J; Rajic, Z; Uzelac, L; Kralj, M; Prudencio, M; Zorc, B. "Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents". MOLECULES (2019):
    10.3390/molecules24152812
  58. Pavic, K; Rubinic, B; Rajic, Z; Fontinha, D; Prudencio, M; Uzelac, L; Kralj, M; Held, J; Zorc, B. "Primaquine homodimers as potential antiplasmodial and anticancer agents". BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019):
    10.1016/j.bmcl.2019.08.018
  59. Arez, F.; Rebelo, S.P.; Fontinha, D.; Simão, D.; Martins, T.R.; Machado, M.; Fischli, C.; et al. "Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting Plasmodium Hepatic Infection". ACS Infectious Diseases (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072884197&partnerID=MN8TOARS.
    10.1021/acsinfecdis.9b00144
  60. Mayoka, Godfrey; Njoroge, Mathew; Okombo, John; Gibhard, Liezl; Sanches-Vaz, Margarida; Fontinha, Diana; Birkholtz, Lyn-Marie; et al. "Structure–Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2-a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria". Journal of Medicinal Chemistry 62 2 (2018): 1022-1035. http://dx.doi.org/10.1021/acs.jmedchem.8b01769.
    10.1021/acs.jmedchem.8b01769
  61. Kumar, Malkeet; Okombo, John; Mambwe, Dickson; Taylor, Dale; Lawrence, Nina; Reader, Janette; van der Watt, Mariëtte; et al. "Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action". ACS Infectious Diseases 5 2 (2018): 303-315. http://dx.doi.org/10.1021/acsinfecdis.8b00272.
    10.1021/acsinfecdis.8b00272
  62. Mendes, António M.; Reuling, Isaie J.; Andrade, Carolina M.; Otto, Thomas D.; Machado, Marta; Teixeira, Filipa; Pissarra, Joana; et al. "Pre-clinical evaluation of a P. berghei-based whole-sporozoite malaria vaccine candidate". npj Vaccines 3 1 (2018): http://dx.doi.org/10.1038/s41541-018-0091-3.
    10.1038/s41541-018-0091-3
  63. Mendes, António M.; Machado, Marta; Gonçalves-Rosa, Nataniel; Reuling, Isaie J.; Foquet, Lander; Marques, Cláudia; Salman, Ahmed M.; et al. "A Plasmodium berghei sporozoite-based vaccination platform against human malaria". npj Vaccines 3 1 (2018): http://dx.doi.org/10.1038/s41541-018-0068-2.
    10.1038/s41541-018-0068-2
  64. Maja Beus; Zrinka Rajic; Dusica Maysinger; Zvonimir Mlinaric; Maja Antunovic; Inga Marijanovic; Diana Fontinha; et al. "SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents". ChemistryOpen 7 8 (2018): 624-638. https://doi.org/10.1002/open.201800117.
    10.1002/open.201800117
  65. Capela, Rita; Magalhães, Joana; Miranda, Daniela; Machado, Marta; Sanches-Vaz, Margarida; Albuquerque, Inês S.; Sharma, Moni; et al. "Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability". European Journal of Medicinal Chemistry 149 (2018): 69-78. http://dx.doi.org/10.1016/j.ejmech.2018.02.048.
    10.1016/j.ejmech.2018.02.048
  66. Pavic, Kristina; Perkovic, Ivana; Pospíšilová, Šárka; Machado, Marta; Fontinha, Diana; Prudêncio, Miguel; Jampilek, Josef; et al. "Primaquine hybrids as promising antimycobacterial and antimalarial agents". European Journal of Medicinal Chemistry 143 (2018): 769-779. http://dx.doi.org/10.1016/j.ejmech.2017.11.083.
    10.1016/j.ejmech.2017.11.083
  67. Šafratová, Marcela; Hoštálková, Anna; Hulcová, Daniela; Breiterová, Katerina; Hrabcová, Veronika; Machado, Marta; Fontinha, Diana; et al. "Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity". Archives of Pharmacal Research 41 2 (2017): 208-218. http://dx.doi.org/10.1007/s12272-017-1000-4.
    10.1007/s12272-017-1000-4
  68. Patrícia Meireles; António M. Mendes; Rita I. Aroeira; Bryan C. Mounce; Marco Vignuzzi; Henry M. Staines; Miguel Prudêncio. "Uptake and metabolism of arginine impact Plasmodium development in the liver". Scientific Reports (2017):
    10.1038/s41598-017-04424-y
  69. Machado, Marta; Sanches-Vaz, Margarida; Cruz, João P.; Mendes, António M.; Prudêncio, Miguel. "Inhibition of Plasmodium Hepatic Infection by Antiretroviral Compounds". Frontiers in Cellular and Infection Microbiology 7 (2017): http://dx.doi.org/10.3389/fcimb.2017.00329.
    10.3389/fcimb.2017.00329
  70. Raquel Azevedo; Marija Markovic; Marta Machado; Blandine Franke-Fayard; António M. Mendes; Miguel Prudêncio. "Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds". Antimicrobial Agents and Chemotherapy 61 6 (2017): e02699-16. https://doi.org/10.1128/AAC.02699-16.
    10.1128/AAC.02699-16
  71. Singh, Kawaljit; Okombo, John; Brunschwig, Christel; Ndubi, Ferdinand; Barnard, Linley; Wilkinson, Chad; Njogu, Peter M.; et al. "Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model". Journal of Medicinal Chemistry 60 4 (2017): 1432-1448. http://dx.doi.org/10.1021/acs.jmedchem.6b01641.
    10.1021/acs.jmedchem.6b01641
  72. Sá e Cunha, Cláudia; Nyboer, Britta; Heiss, Kirsten; Sanches-Vaz, Margarida; Fontinha, Diana; Wiedtke, Ellen; Grimm, Dirk; et al. "Plasmodium bergheiEXP-1 interacts with host Apolipoprotein H duringPlasmodiumliver-stage development". Proceedings of the National Academy of Sciences 114 7 (2017): E1138-E1147. http://dx.doi.org/10.1073/pnas.1606419114.
    10.1073/pnas.1606419114
  73. Macedo, Taís S.; Villarreal, Wilmer; Couto, Camila C.; Moreira, Diogo R. M.; Navarro, Maribel; Machado, Marta; Prudêncio, Miguel; Batista, Alzir A.; Soares, Milena B. P.. "Platinum(ii)–chloroquine complexes are antimalarial agents against blood and liver stages by impairing mitochondrial function". Metallomics 9 11 (2017): 1548-1561. http://dx.doi.org/10.1039/c7mt00196g.
    10.1039/c7mt00196g
  74. Mendes, António M.; Albuquerque, Inês S.; Machado, Marta; Pissarra, Joana; Meireles, Patrícia; Prudêncio, Miguel. "Inhibition of Plasmodium liver infection by ivermectin". Antimicrobial Agents and Chemotherapy (2016): AAC.02005-16. http://dx.doi.org/10.1128/aac.02005-16.
    10.1128/aac.02005-16
  75. Carrasco, Marta P.; Machado, Marta; Gonçalves, Lídia; Sharma, Moni; Gut, Jiri; Lukens, Amanda K.; Wirth, Dyann F.; et al. "Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites". ChemMedChem 11 19 (2016): 2194-2204. http://dx.doi.org/10.1002/cmdc.201600327.
    10.1002/cmdc.201600327
  76. Meireles, Patrícia; Sales-Dias, Joana; Andrade, Carolina M.; Mello-Vieira, João; Mancio-Silva, Liliana; Simas, J. Pedro; Staines, Henry M.; et al. "GLUT1-mediated glucose uptake plays a crucial role duringPlasmodiumhepatic infection". Cellular Microbiology 19 2 (2016): e12646. http://dx.doi.org/10.1111/cmi.12646.
    10.1111/cmi.12646
  77. MACEDO, TAÍS S.; COLINA-VEGAS, LEGNA; DA PAIXÃO, MARCELO; NAVARRO, MARIBEL; BARRETO, BRENO C.; OLIVEIRA, POLIANA C. M.; MACAMBIRA, SIMONE G.; et al. "Chloroquine-containing organoruthenium complexes are fast-acting multistage antimalarial agents". Parasitology 143 12 (2016): 1543-1556. http://dx.doi.org/10.1017/s0031182016001153.
    10.1017/s0031182016001153
  78. Ribeiro, Carlos J.A.; Espadinha, Margarida; Machado, Marta; Gut, Jiri; Gonçalves, Lídia M.; Rosenthal, Philip J.; Prudêncio, Miguel; Moreira, Rui; Santos, Maria M.M.. "Novel squaramides with in vitro liver stage antiplasmodial activity". Bioorganic & Medicinal Chemistry 24 8 (2016): 1786-1792. http://dx.doi.org/10.1016/j.bmc.2016.03.005.
    10.1016/j.bmc.2016.03.005
  79. Ferraz, R; Noronha, J; Murtinheira, F; Nogueira, F; Machado, M; Prudencio, M; Parapini, S; et al. "Primaquine-based ionic liquids as a novel class of antimalarial hits". RSC ADVANCES (2016):
    10.1039/c6ra10759a
  80. Cavadas, MAS; Monopoli, MP; Sa e Cunha, CSE; Prudencio, M; Pereira, E; Lynch, I; Dawson, KA; Franco, R. "Unravelling Malaria Antigen Binding to Antibody-Gold Nanoparticle Conjugates". PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2016):
    10.1002/ppsc.201600187
  81. Terzic, Natasa; Konstantinovic, Jelena; Tot, Mikloš; Burojevic, Jovana; Djurkovic-Djakovic, Olgica; Srbljanovic, Jelena; Štajner, Tijana; et al. "Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?". Journal of Medicinal Chemistry 59 1 (2015): 264-281. http://dx.doi.org/10.1021/acs.jmedchem.5b01374.
    10.1021/acs.jmedchem.5b01374
  82. Pereira, Nuno A. L.; Monteiro, Ângelo; Machado, Marta; Gut, Jiri; Molins, Elies; Perry, M. Jesus; Dourado, Jorge; et al. "Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites". ChemMedChem 10 12 (2015): 2080-2089. http://dx.doi.org/10.1002/cmdc.201500429.
    10.1002/cmdc.201500429
  83. Kaur, Hardeep; Machado, Marta; de Kock, Carmen; Smith, Peter; Chibale, Kelly; Prudêncio, Miguel; Singh, Kamaljit. "Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity". European Journal of Medicinal Chemistry 101 (2015): 266-273. http://dx.doi.org/10.1016/j.ejmech.2015.06.045.
    10.1016/j.ejmech.2015.06.045
  84. Gomes, Ana; Machado, Marta; Lobo, Lis; Nogueira, Fátima; Prudêncio, Miguel; Teixeira, Cátia; Gomes, Paula. "N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials". ChemMedChem 10 8 (2015): 1344-1349. http://dx.doi.org/10.1002/cmdc.201500164.
    10.1002/cmdc.201500164
  85. Lewis, Matthew D.; Behrends, Jochen; Sá e Cunha, Cláudia; Mendes, António M.; Lasitschka, Felix; Sattler, Julia M.; Heiss, Kirsten; et al. "Chemical Attenuation ofPlasmodiumin the Liver Modulates Severe Malaria Disease Progression". The Journal of Immunology 194 10 (2015): 4860-4870. http://dx.doi.org/10.4049/jimmunol.1400863.
    10.4049/jimmunol.1400863
  86. Rodrigues, Catarina A. B.; Frade, Raquel F. M.; Albuquerque, Inês S.; Perry, Maria J.; Gut, Jiri; Machado, Marta; Rosenthal, Philip J.; et al. "Targeting the Erythrocytic and Liver Stages of Malaria Parasites withs-Triazine-Based Hybrids". ChemMedChem 10 5 (2015): 883-890. http://dx.doi.org/10.1002/cmdc.201500011.
    10.1002/cmdc.201500011
  87. Liehl, Peter; Meireles, Patrícia; Albuquerque, Inês S.; Pinkevych, Mykola; Baptista, Fernanda; Mota, Maria M.; Davenport, Miles P.; Prudêncio, Miguel. "Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections". Infection and Immunity 83 3 (2015): 1172-1180. http://dx.doi.org/10.1128/iai.02796-14.
    10.1128/iai.02796-14
  88. Ramalhete C; da Cruz FP; Mulhovo S; Sousa IJ; Fernandes MX; Prudêncio M; Ferreira MJ; et al. "Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite.". Bioorganic & Medicinal Chemistry 22 15 (2014): 3887-3890. http://europepmc.org/abstract/med/25002232.
    10.1016/j.bmc.2014.06.019
  89. Oliveira R; Guedes RC; Meireles P; Albuquerque IS; Gonçalves LM; Pires E; Bronze MR; et al. "Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials.". Journal of Medicinal Chemistry 57 11 (2014): 4916-4923. http://europepmc.org/abstract/med/24824551.
    10.1021/jm5004528
  90. Gomes, Ana; Pérez, Bianca; Albuquerque, Inês; Machado, Marta; Prudêncio, Miguel; Nogueira, Fátima; Teixeira, Cátia; et al. "N-Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity". ChemMedChem 9 2 (2013): 305-310. http://dx.doi.org/10.1002/cmdc.201300459.
    10.1002/cmdc.201300459
  91. Miranda, Daniela; Capela, Rita; Albuquerque, Inês S.; Meireles, Patrícia; Paiva, Isa; Nogueira, Fátima; Amewu, Richard; et al. "Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities". ACS Medicinal Chemistry Letters 5 2 (2013): 108-112. http://dx.doi.org/10.1021/ml4002985.
    10.1021/ml4002985
  92. Rodrigues, Tiago; Ressurreição, Ana S.; da Cruz, Filipa P.; Albuquerque, Inês S.; Gut, Jiri; Carrasco, Marta P.; Gonçalves, Daniel; et al. "Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds". European Journal of Medicinal Chemistry 69 (2013): 872-880. http://dx.doi.org/10.1016/j.ejmech.2013.09.008.
    10.1016/j.ejmech.2013.09.008
  93. Rodrigues, Tiago; da Cruz, Filipa P.; Lafuente-Monasterio, Maria J.; Gonçalves, Daniel; Ressurreição, Ana S.; Sitoe, Ana R.; Bronze, Maria R.; et al. "Quinolin-4(1H)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria". Journal of Medicinal Chemistry 56 11 (2013): 4811-4815. http://dx.doi.org/10.1021/jm400246e.
    10.1021/jm400246e
  94. Prudêncio M; Mota MM. "Targeting host factors to circumvent anti-malarial drug resistance.". (2013): http://europepmc.org/abstract/med/22973886.
    10.2174/138161213804070276
  95. Pérez, B. C.; Teixeira, C.; Albuquerque, I. S.; Gut, J.; Rosenthal, P. J.; Gomes, J. R.; Prudêncio, M.; Gomes, P.. "N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads". J Med Chem 56 2 (2013): 556-67.
    10.1021/jm301654b
  96. Liehl, P.; Zuzarte-Luís, V.; Chan, J.; Zillinger, T.; Baptista, F.; Carapau, D.; Konert, M.; et al. "Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection". Nature Medicine 20 1 (2013): 47-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890368942&partnerID=MN8TOARS.
    10.1038/nm.3424
  97. Pérez, B.; Teixeira, C.; Gomes, A.S.; Albuquerque, I.S.; Gut, J.; Rosenthal, P.J.; Prudêncio, M.; Gomes, P.. "In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites". Bioorganic and Medicinal Chemistry Letters 23 3 (2013): 610-613. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872313641&partnerID=MN8TOARS.
    10.1016/j.bmcl.2012.12.032
  98. Hanson, K.K.; Ressurreicao, A.S.; Buchholz, K.; Prudencio, M.; Herman-Ornelas, J.D.; Rebelo, M.; Beatty, W.L.; et al. "Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins". Proceedings of the National Academy of Sciences of the United States of America 110 30 (2013): E2838-E2847. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880650998&partnerID=MN8TOARS.
    10.1073/pnas.1306097110
  99. Dempsey, E.; Prudêncio, M.; Fennell, B.J.; Gomes-Santos, C.S.; Barlow, J.W.; Bell, A.; Dempsey, Enda; et al. "Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites". Molecular and Biochemical Parasitology 188 2 (2013): 116-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878111842&partnerID=MN8TOARS.
    10.1016/j.molbiopara.2013.03.001
  100. Lin, J.-W.; Meireles, P.; Prudêncio, M.; Engelmann, S.; Annoura, T.; Sajid, M.; Chevalley-Maurel, S.; et al. "Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family". Molecular Microbiology 88 2 (2013): 318-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876164304&partnerID=MN8TOARS.
    10.1111/mmi.12187
  101. Ressurreição, A. S.; Gonçalves, D.; Sitoe, A. R.; Albuquerque, I. S.; Gut, J.; Góis, A.; Gonçalves, L. M.; et al. "Structural optimization of Quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability". J Med Chem 56 19 (2013): 7679-90. http://dx.doi.org/10.1021/jm4011466.
    10.1021/jm4011466
  102. Eaton, P.; Zuzarte-Luis, V.; Mota, M.M.; Santos, N.C.; Prudêncio, M.. "Infection by Plasmodium changes shape and stiffness of hepatic cells". Nanomedicine: Nanotechnology, Biology, and Medicine 8 1 (2012): 17-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855332785&partnerID=MN8TOARS.
    10.1016/j.nano.2011.10.004
  103. Pérez, B.; Teixeira, C.; Albuquerque, I.S.; Gut, J.; Rosenthal, P.J.; Prudêncio, M.; Gomes, P.. "PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity". MedChemComm 3 9 (2012): 1170-1172. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865474868&partnerID=MN8TOARS.
    10.1039/c2md20113e
  104. Derbyshire, E.R.; Prudêncio, M.; Mota, M.M.; Clardy, J.. "Liver-stage malaria parasites vulnerable to diverse chemical scaffolds". Proceedings of the National Academy of Sciences of the United States of America 109 22 (2012): 8511-8516. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861904136&partnerID=MN8TOARS.
    10.1073/pnas.1118370109
  105. Guirgis, Bassem S. S.; Sa e Cunha, Claudia; Gomes, Ines; Cavadas, Miguel; Silva, Isabel; Doria, Goncalo; Blatch, Gregory L.; et al. "Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection". Analytical and Bioanalytical Chemistry 402 3 (2012): 1019-1027.
    10.1007/s00216-011-5489-y
  106. da Cruz, Filipa P.; Martin, Cecilie; Buchholz, Kathrin; Lafuente-Monasterio, Maria J.; Rodrigues, Tiago; Soennichsen, Birte; Moreira, Rui; et al. "Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug". Journal of Infectious Diseases 205 8 (2012): 1278-1286.
    10.1093/infdis/jis184
  107. Rodrigues, Tiago; Prudencio, Miguel; Moreira, Rui; Mota, Maria M.; Lopes, Francisca. "Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal". Journal of Medicinal Chemistry 55 3 (2012): 995-1012.
    10.1021/jm201095h
  108. Matos, J; da Cruz, FP; Cabrita, E; Gut, J; Nogueira, F; do Rosario, VE; Moreira, R; et al. "Novel Potent Metallocenes against Liver Stage Malaria". ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 56 3 (2012): 1564-1570.
    10.1128/aac.05345-11
  109. Slavic, Ksenija; Delves, Michael J.; Prudencio, Miguel; Talman, Arthur M.; Straschil, Ursula; Derbyshire, Elvira T.; Xu, Zhengyao; et al. "Use of a Selective Inhibitor To Define the Chemotherapeutic Potential of the Plasmodial Hexose Transporter in Different Stages of the Parasite's Life Cycle". Antimicrobial Agents and Chemotherapy 55 6 (2011): 2824-2830.
    10.1128/AAC.01739-10
  110. Ramalhete, Catia; da Cruz, Filipa P.; Lopes, Dinora; Mulhovo, Silva; Rosario, Virgilio E.; Prudencio, Miguel; Ferreira, Maria-Jose U.. "Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections". Bioorganic & Medicinal Chemistry 19 24 (2011): 7474-7481.
    10.1016/j.bmc.2011.10.044
  111. Gomes-Santos, Carina S. S.; Braks, Joanna; Prudencio, Miguel; Carret, Celine; Gomes, Ana Rita; Pain, Arnab; Feltwell, Theresa; et al. "Transition of Plasmodium Sporozoites into Liver Stage-Like Forms Is Regulated by the RNA Binding Protein Pumilio". Plos Pathogens 7 5 (2011):
    10.1371/journal.ppat.1002046
  112. Almeida, Celso; Kehraus, Stefan; Prudencio, Miguel; Koenig, Gabriele M.. "Marilones A-C, phthalides from the sponge-derived fungus Stachylidium sp.". Beilstein Journal of Organic Chemistry 7 (2011): 1636-1642.
    10.3762/bjoc.7.192
  113. Lavrado, Joao; Cabal, Ghislain G.; Prudencio, Miguel; Mota, Maria M.; Gut, Jiri; Rosenthal, Philip J.; Diaz, Cecilia; et al. "Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure-Antimalarial Activity Relationships and Mechanistic Studies". Journal of Medicinal Chemistry 54 3 (2011): 734-750.
    10.1021/jm101383f
  114. Prudencio, Miguel; Mota, Maria M.; Mendes, Antonio M.. "A toolbox to study liver stage malaria". Trends in Parasitology 27 12 (2011): 565-574.
    10.1016/j.pt.2011.09.004
  115. Capela, R; Cabal, GG; Rosenthal, PJ; Gut, J; Mota, MM; Moreira, R; Lopes, F; et al. "Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Antimalarial Strategy". ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 55 10 (2011): 4698-4706.
    10.1128/aac.05133-11
  116. Liehl, Peter; Franca, Ana Rita; Prudencio, Miguel; Latz, Eicke; Zaidman-Remy, Anna; Mota, Maria M.. "Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility". Cellular Microbiology 12 4 (2010): 506-515.
    10.1111/j.1462-5822.2009.01411.x
  117. Gomes-Santos CS; Braks JAM; Prudêncio M; Carret CK; Gomes AR; Pain A; Feltwell T; et al. "Developmental transition of Plasmodium sporozoites into liver-stage forms is regulated by the RNA binding protein Pumilio 2.". (2010): http://europepmc.org/abstract/PMC/PMC2963252.
  118. Prudencio, Miguel; Derbyshire, Elvira T.; Marques, Catarina A.; Krishna, Sanjeev; Mota, Maria M.; Staines, Henry M.. "Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells". Cellular Microbiology 11 10 (2009): 1492-1501.
    10.1111/j.1462-5822.2009.01342.x
  119. Vale, Nuno; Prudencio, Miguel; Marques, Catarina A.; Collins, Margaret S.; Gut, Jiri; Nogueira, Fatima; Matos, Joana; et al. "Imidazoquines as Antimalarial and Antipneumocystis Agents". Journal of Medicinal Chemistry 52 23 (2009): 7800-7807.
    10.1021/jm900738c
  120. Albuquerque, Sonia S.; Carret, Celine; Grosso, Ana Rita; Tarun, Alice S.; Peng, Xinxia; Kappe, Stefan H. I.; Prudencio, Miguel; Mota, Maria M.. "Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events". Bmc Genomics 10 (2009):
    10.1186/1471-2164-10-270
  121. Parvanova, Iana; Epiphanio, Sabrina; Fauq, Abdul; Golde, Todd E.; Prudencio, Miguel; Mota, Maria M.. "A Small Molecule Inhibitor of Signal Peptide Peptidase Inhibits Plasmodium Development in the Liver and Decreases Malaria Severity". Plos One 4 4 (2009):
    10.1371/journal.pone.0005078
  122. Ploemen, Ivo H. J.; Prudencio, Miguel; Douradinha, Bruno G.; Ramesar, Jai; Fonager, Jannik; van Gemert, Geert-Jan; Luty, Adrian J. F.; et al. "Visualisation and Quantitative Analysis of the Rodent Malaria Liver Stage by Real Time Imaging". Plos One 4 11 (2009):
    10.1371/journal.pone.0007881
  123. Prudêncio, M.; Lehmann, M.J.. "Illuminating the host - How RNAi screens shed light on host-pathogen interactions". Biotechnology Journal 4 6 (2009): 826-837. http://www.scopus.com/inward/record.url?eid=2-s2.0-68049093863&partnerID=MN8TOARS.
    10.1002/biot.200900071
  124. Prudencio, Miguel; Rodrigues, Cristina D.; Hannus, Michael; Martin, Cecilie; Real, Eliana; Goncalves, Ligia A.; Carret, Celine; et al. "Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection". Plos Pathogens 4 11 (2008):
    10.1371/journal.ppat.1000201
  125. Silvie, Olivier; Mota, Maria M.; Matuschewski, Kai; Prudencio, Miguel. "Interactions of the malaria parasite and its mammalian host". Current Opinion in Microbiology 11 4 (2008): 352-359.
    10.1016/j.mib.2008.06.005
  126. Rodrigues, Cristina D.; Hannus, Michael; Prudencio, Miguel; Martin, Cecilie; Goncalves, Ligia A.; Portugal, Silvia; Epiphanio, Sabrina; et al. "Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection". Cell Host & Microbe 4 3 (2008): 271-282.
    10.1016/j.chom.2008.07.012
  127. Cunha-Rodrigues, Margarida; Portugal, Silvia; Prudencio, Miguel; Goncalves, Ligia A.; Casalou, Cristina; Buger, Dominik; Sauerwein, Robert; Haas, Werner; Mota, Maria M.. "Genistein-Supplemented Diet Decreases Malaria Liver Infection in Mice and Constitutes a Potential Prophylactic Strategy". Plos One 3 7 (2008):
    10.1371/journal.pone.0002732
  128. Prudencio, Miguel; Rodrigues, Cristina D.; Ataide, Ricardo; Mota, Maria M.. "Dissecting in vitro host cell infection by Plasmodium sporozoites using flow cytometry". Cellular Microbiology 10 1 (2008): 218-224.
    10.1111/j.1462-5822.2007.01032.x
  129. Vlasie, Monica D.; Fernandez-Busnadiego, Ruben; Prudencio, Miguel; Ubbink, Marcellus. "Conformation of pseudoazurin in the 152 kDa electron transfer complex with nitrite reductase determined by paramagnetic NMR". Journal of Molecular Biology 375 5 (2008): 1405-1415.
    10.1016/j.jmb.2007.11.056
  130. Finiguerra, Michela G.; Prudencio, Miguel; Ubbink, Marcellus; Huber, Martina. "Accurate long-range distance measurements in a doubly spin-labeled protein by a four-pulse, double electron-electron resonance method". Magnetic Resonance in Chemistry 46 12 (2008): 1096-1101.
    10.1002/mrc.2290
  131. Prudencio, Miguel; Mota, Maria M.; Prudêncio M; Mota MM. "To migrate or to invade: Those are the options". Cell Host & Microbe 2 5 (2007): 286-288. http://europepmc.org/abstract/med/18005748.
    10.1016/j.chom.2007.10.008
  132. Vlasie, Monica D.; Comuzzi, Clara; van den Nieuwendijk, Adrianus M. C. H.; Prudencio, Miguel; Overhand, Mark; Ubbink, Marcellus. "Long-range-distance NMR effects in a protein labeled with a lanthanide-DOTA chelate". Chemistry-a European Journal 13 6 (2007): 1715-1723.
    10.1002/chem.200600916
  133. Prudencio, Miguel; Rodriguez, Ana; Mota, Maria M.. "The silent path to thousands of merozoites: the Plasmodium liver stage". Nature Reviews Microbiology 4 11 (2006): 849-856.
    10.1038/nrmicro1529
  134. de Jongh, Thyra E.; van Roon, Anne-Marie M.; Prudencio, Miguel; Ubbink, Marcellus; Canters, Gerard W.. "Click chemistry with an active site variant of azurin". European Journal of Inorganic Chemistry 19 (2006): 3861-3868.
    10.1002/ejic.200600574
  135. Cunha-Rodrigues, M.; Prudêncio, M.; Mota, M.M.; Haas, W.. "Antimalarial drugs - host targets (re)visited.". Biotechnology journal 1 3 (2006): 321-332. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749008528&partnerID=MN8TOARS.
    10.1002/biot.200500038
  136. Worrall, JAR; Diederix, REM; Prudencio, M; Lowe, CE; Ciofi-Baffoni, S; Ubbink, M; Canters, GW. "The effects of ligand exchange and mobility on the peroxidase activity of a bacterial cytochrome c upon unfolding". Chembiochem 6 4 (2005): 747-758.
    10.1002/cbic.200400291
  137. Harris, RL; Prudencio, M; Hasnain, SS; Eady, RR; Sawers, RG. "Heterologous metalloprotein biosynthesis in Escherichia coli: conditions for the overproduction of functional copper-containing nitrite reductase and azurin from Alcaligenes xylosoxidans". JOURNAL OF SYNCHROTRON RADIATION 12 (2005): 13-18.
    10.1107/s0909049504027852
  138. Prudencio, M; Rohovec, J; Peters, JA; Tocheva, E; Boulanger, MJ; Murphy, MEP; Hupkes, HJ; et al. "A caged lanthanide complex as a paramagnetic shift agent for protein NMR". Chemistry-a European Journal 10 13 (2004): 3252-3260.
    10.1002/chem.200306019
  139. Prudencio, M; Ubbink, M. "Transient complexes of redox proteins: structural and dynamic details from NMR studies". Journal of Molecular Recognition 17 6 (2004): 524-539.
    10.1002/jmr.686
  140. Farver, O; Eady, RR; Sawers, G; Prudencio, M; Pecht, I. "Met144A1a mutation of the copper-containing nitrite reductase from Alcaligenes xylosoxidans reverses the intramolecular electron transfer". Febs Letters 561 1-3 (2004): 173-176.
    10.1016/S0014-5793(04)00171-1
  141. de Jongh, TE; Prudencio, M; Ubbink, M; Canters, GW. "Modelling protein-protein electron transfer in cross-linked dimers of azurin". Journal of Inorganic Biochemistry 96 1 (2003): 161-161.
    10.1016/S0162-0134(03)80663-3
  142. Ellis, MJ; Prudencio, M; Dodd, FE; Strange, RW; Sawers, G; Eady, RR; Hasnain, SS. "Biochemical and crystallographic studies of the Met144Ala, Asp92Asn and His254Phe mutants of the nitrite reductase from Alcaligenes xylosoxidans provide insight into the enzyme mechanism". Journal of Molecular Biology 316 1 (2002): 51-64.
    10.1006/jmbi.2001.5304
  143. Prudencio, M; Sawers, G; Fairhurst, SA; Yousafzai, FK; Eady, RR. "Alcaligenes xylosoxidans dissimilatory nitrite reductase: Alanine substitution of the surface-exposed histidine 139 ligand of the type 1 copper center prevents electron transfer to the catalytic center". Biochemistry 41 10 (2002): 3430-3438.
    10.1021/bi011955c
  144. Ellis, MJ; Dodd, FE; Strange, RW; Prudencio, M; Sawers, G; Eady, RR; Hasnain, SS. "X-ray structure of a blue copper nitrite reductase at high pH and in copper-free form at 1.9 angstrom resolution". Acta Crystallographica Section D-Biological Crystallography 57 (2001): 1110-1118.
    10.1107/S0907444901008654
  145. Prudencio, M; Eady, RR; Sawers, G. "Catalytic and spectroscopic analysis of blue copper-containing nitrite reductase mutants altered in the environment of the type 2 copper centre: implications for substrate interaction". Biochemical Journal 353 (2001): 259-266.
    10.1042/0264-6021:3530259
  146. Brown, K.; Tegoni, M.; Prudêncio, M.; Pereira, A.S.; Besson, S.; Moura, J.J.; Moura, I.; Cambillau, C.. "A novel type of catalytic copper cluster in nitrous oxide reductase". Nature Structural Biology 7 3 (2000): 191-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034049124&partnerID=MN8TOARS.
    10.1038/73288
  147. Prudencio, M; Pereira, AS; Tavares, P; Besson, S; Cabrito, I; Brown, K; Samyn, B; et al. "Purification, characterization, and preliminary crystallographic study of copper-containing nitrous oxide reductase from Pseudomonas nautica 617". Biochemistry 39 14 (2000): 3899-3907.
    10.1021/bi9926328
  148. Prudêncio M; Eady RR; Sawers G; Prudêncio, M.; Eady, R.R.; Sawers, G.. "The blue copper-containing nitrite reductase from Alcaligenes xylosoxidans: cloning of the nirA gene and characterization of the recombinant enzyme.". Journal of Bacteriology 181 8 (1999): 2323-2329. http://europepmc.org/abstract/med/10197991.
Capítulo de livro
  1. Prudêncio, Miguel; Mendes, A.M.; Scholzen, A.; Mueller, A.-K.; Khan, S.M.; Sauerwein, R.W.; Prudêncio, M.. "Whole-Sporozoite Malaria Vaccines". In Malaria, 99-137. Suiça: Springer International Publishing, 2017.
    10.1007/978-3-319-45210-4
  2. Prudêncio, M.; Rodrigues, C.D.; Mota, M.M.; Prudêncio M; Rodrigues CD; Mota MM. "The relevance of host genes in Malaria". In Comparative Genomics and Proteomics in the Identification of New Drug Targets, 47-91. Oxford, Reino Unido: Taylor & Francis, 2006.
    Publicado
Resumo em conferência
  1. Ramalhete, CL; Cruz, A; Mulhovo, S; Prudencio, M; Ferreira, MU. "Triterpenoids as inhibitors of Plasmodium liver-stage development". 2011.
  2. Lopes, F; Capela, R; Moreira, R; Rosenthal, PJ; Gut, J; Cabal, G; Prudencio, M; Mota, M. "Hybrid compounds targeting both liver and blood stages of malaria parasites". 2010.
  3. Gomes, P; Vale, N; Matos, J; Gut, J; Collins, M; Prudencio, M; Mota, M; et al. "Imidazoquines: proline-mimetic derivatives of primaquine with antimalarial activity". 2010.
  4. Rodrigues, CD; Hannus, M; Prudencio, M; Martin, C; Goncalves, LA; Portugal, S; Akinc, A; et al. "SR-BI is a crucially required host factor with a dual role in the establishment of malaria liver infection.". 2008.
  5. Prudencio, M; Impagliazzo, A; Ubbink, M; Rohovec, J; Peters, J. "CLaNP - An artificial paramagnetic centre to study proteins by NMR". 2003.
    10.1016/s0162-0134(03)80743-2
  6. Prudencio, M; Rohovec, J; Peters, J; Velders, A; Haasnoot, J; Verbeet, M; Ubbink, M. "Development of a paramagnetic probe for the study of protein-protein complexes". 2001.

Outros

Outra produção
  1. Half- Sandwich cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype. 2020. Sofia Alexandra Milheiro; Joana Gonçalves; Ricardo Lopes; Margarida Madureira; Lis Lobo; Andreia Lopes; Fatima Nogueira; et al. https://doi.org/10.26434/chemrxiv.12155178.v1.
    10.26434/chemrxiv.12155178.v1
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/11/10 Lessons learnt from the first licensed mRNA vaccines for COVID-19 39º Congresso da Sociedade Portuguesa de Pneumologia
Sociedade Portuguesa de Pneumologia (Albufeira, Portugal)
2023/07/15 Lessons learnt from the first licensed mRNA vaccines for COVID-19 Congresso Saúde Pública 23
(Lisboa, Portugal)
2023/07/05 Recent advances and new strategies for malaria vaccination 6th Egas Moniz International Scientific Congres
(Monte de Caparica, Portugal)
2023/03/15 Messenger RNA and new vaccines Basic Sciences for Sustainable Development
Academia das Ciências de Lisboa (Lisboa, Portugal)
2022/11/24 Desenvolvimento de uma nova vacina contra a malária Sessões Clínicas ‘O que Há de Novo no CAML
Faculdade de Medicina da Universidade de Lisboa (Lisboa, Portugal)
2022/11/11 Vacinação contra a COVID-19: que vacinas e quem vacinar? 38º Congresso da Sociedade Portuguesa de Pneumologia
Sociedade Portuguesa de Pneumologia (Albufeira, Portugal)
2022/11/04 Recent progress in P. berghei-based malaria vaccination International PfSPZ Consortium Meeting
Sanaria - Seattle Children's (Seattle, Estados Unidos)
2022/09/20 A new strategy to vaccinate against malaria Seminars of the Department of Biology of Universidade do Minho
Universidade do Minho (Braga, Portugal)
2022/09/05 A new era of vaccine development European Respiratory Society Congress 2022
European Respiratory Society (Barcelona, Espanha)
2022/09/05 Approaches to targeting COVID-19 European Respiratory Society Congress 2022
European Respiratory Society (Barcelona, Espanha)
2022/06/07 O longo caminho até uma vacina eficaz contra a malária Webinar Colégio Tropical
Colégio Tropical - Universidade de Lisboa (Portugal)
2022/05/23 O poder da ciência nos progressos da medicina mudará as nossas vidas? PSuperior Talks
Público (Lisboa, Portugal)
2022/04/22 Immune responses to wgole-organism malaria vaccination XLVII Annual Meeting of the Portuguese Society for Immunology
Portuguese Society for Immunology (Lisboa, Portugal)
2022/04/14 Novas vacinas contra a COVID-19 – o que conseguimos e os novos desafios IV Conferência Infecção e Doenças Infecciosas
(Campo Maior, Portugal)
2022/04/09 Malaria vaccines I Conferência FMUL/FMUC Doenças Infecciosas e Vacinas
Faculdade de Medicina da Universidade de Lisboa (Lisboa, Portugal)
2022/03/17 COVID-19 – O bebé elefante Pfizer webinar
Pfizer (Portugal)
2022/01/13 Da pergunta científica à patente Seminário - Mestrado em Investigação Clínica
(Portugal)
2021/12/10 Further development of P. berghei-based malaria vaccines International PfSPZ Consortium Meeting
Sanaria, Inc. (Estados Unidos)
2021/11/30 Disease prevention through vaccination 5ª Conferência da redeSAÚDE - A Health Research Agenda towards 2030
(Portugal)
2021/11/17 Generation, characterization and in vivo evaluation of a novel live malaria vaccine 0th Anniversary Symposium of the Tres Cantos OpenLab Foundation
(Espanha)
2021/11/11 Vacinação contra a COVID-19. O que conseguimos e os novos desafios 37º Congresso da Sociedade Portuguesa de Pneumologia
(Portugal)
2021/10/22 Future perspectives for technological and data-based innovation Lisbon Living+, 2nd Annual Conference: The COVID-19 Pandemic - The Day After
Universidade Nova de Lisboa (Portugal)
2021/05/25 Pre-clinical and clinical evaluation of a P. berghei-based vaccine against human malaria BioMalPar XVII: Biology and Pathology of the Malaria Parasite
EMBL (Alemanha)
2021/05/13 Vacinação contra a COVID-19 em Portugal: Ponto de situação Webinar
Sociedade Portuguesa de Pneumologia (Portugal)
2021/05/02 Desafios à investigação biomédica em Portugal Encontro: mais saúde para vencer a crise - Vacinas, investigação e produção
(Portugal)
2021/04/11 COVID-19, the next chapter: The road to the vaccine and its role from now on Oporto Biomedical Summit
(Portugal)
2021/03/28 The role of biotechnology in combating pandemics and the evolution of science in the context of COVID-19 XII Symposium on Bioengeneering
(Portugal)
2021/01/20 COVID-ZERO - COVID-19, O que Preocupa as Empresas: 2021 e Agora? - Testagem e Vacinação Webinar
Trivalor (Portugal)
2021/01/15 Challenges and Opportunities in Tropical Research and Cooperation Webinar
Colégio Tropical Universidade de Lisboa
2020/12/09 How do Vaccines Work and Can They Pave the Way to a Post-COVID-19 Era Leadership E-Town Hall
BNP Paribas Portugal
2020/12/03 Development and Clinical Evaluation of a New Vaccine Against Malaria Sessões Académicas - Classe de Ciências
Academia das Ciências de Lisboa
2020/11/25 Biomedical Research in Vaccine Development Workshop Science Talks: How Vaccines are Developed, Approved and Produced, AICIB/EATRIS/PtCRIN
2020/04/29 Sharing Information Together, "Vamos falar de vacinas" ("Let's talk about vaccines") Webinar
Co-Life
2019/11/27 Development and Clinical Evaluation of a New Vaccine Against Malaria Seminar in Master's in Human Biology and Environment
2019/11/19 PbSPZ-PfCSP (PbVac) - Results of Clinical Trial and Future Plans International PfSPZ Consortium Meeting
(Rockville, Estados Unidos)
2019/09/18 Plasmodium berghei Sporozoites Expressing PfCSP as a Whole-Sporozoite-Based Malaria Vaccine Candidate Sanaria, Inc.
Steve Hoffman (Rockville, Estados Unidos)
2019/05/20 Um Regresso às Origens na Busca de uma Vacina Contra a Malária Pint of Science Portugal 2019
(Lisboa, Portugal)
2019/03/07 Aquecimento Global e Ressurgimento da Malária - Perspetivas para Portugal XII Congresso Científico do Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra
(Coimbra, Portugal)
2019/02/25 Development and Clinical Evaluation of a New Vaccine Against Malaria 1st International Conference on Integrative Chemistry, Biology & Translational Medicine
(Delhi, Índia)
2019/02/25 Development and Clinical Evaluation of a New Vaccine Against Malaria 1st International Conference on Integrative Chemistry, Biology & Translational Medicine
(Delhi, Índia)
2018/12/19 Plasmodium Liver Infection and Antimalarial Strategies iMM Internal Seminar
(Lisboa, Portugal)
2018/11/16 Plasmodium Infection and Antimalarial Strategies iMM Summit
(Lisboa, Portugal)
2018/11/13 Em Busca de uma Vacina Contra a Malária Mais Ciência Melhor Sociedade
FCT (Porto, Portugal)
2018/10/18 Desenvolvimento e Avaliação Clínica de uma Nova Vacina Contra a Encontro Internacional de Inovação em Saúde do Distrito Federal
(Brasília, Brasil)
2018/09/21 Clinical Evaluation of a New Vaccine Against Malaria Delegates of 9th EDCTP Forum
(Lisboa, Portugal)
2018/06/10 Clinical Evaluation of a New Vaccine Against Malaria Gordon Research Conference on Biology of Host-Parasite Interactions 2018
(Newport, Estados Unidos)
2018/05/30 Pensar Fora da Caixa em Busca de uma Vacina Contra a Malária TEDx Youth @ Estoril School
(Estoril, Portugal)
2018/05/09 Pre-Clinical and Early Clinical Evaluation of a Plasmodium berghei Sporozoite-Based Malaria Vaccine DZIF Seminar Series on Malaria Cross Talk Between Field and Bench Research
(Heidelberg, Alemanha)
2018/04/08 Pre-Clinical and Early Clinical Evaluation of a Plasmodium berghei Sporozoite-Based Malaria Vaccine British Society for Parasitology Meeting 2018
(Aberystwyth, Reino Unido)
2018/03/23 Clinical Evaluation of a New Vaccine Against Malaria IV Encontro Nacional de Estudantes de Biotecnologia
(Covilhã, Portugal)
2018/03/19 A New Malaria Vaccine Enters Clinical Evaluation TwinnToInfect Spring School
(Lisboa, Portugal)
2018/01/14 Towards Clinical Evaluation of a New Malaria Vaccine Towards Clinical Evaluation of a New Malaria Vaccine
(Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020 - 2024 New developments in whole-sporozoite vaccination against malaria
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2022 - 2023 Characterization of a novel whole-sporozoite vaccine against malaria
Orientador
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2023 Plasmodium berghei/SARS-CoV-2 co-infection phenotype in murine models
Orientador
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2023 Using a high-throughput genetic screen to identify Plasmodium molecules that interact with the host’s innate immune system
Coorientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021 - 2023 Screening of compounds against malaria parasites
Coorientador
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - 2023 Targeting the transmission stage of malaria parasites by drug- and vaccine-based approaches
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2021 - 2022 Drug repurposing against malaria parasites
Coorientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2021 - 2022 Comparative efficacy analysis of whole-sporozoite vaccines against malaria
Coorientador
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2022 Unravelling the role of Trypanosoma brucei proteins in the impairment of Plasmodium infection
Coorientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2022 Novel spiro-lactams as new antimicrobial agents
Coorientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017 - 2022 Advancing liver-stage malaria in vitro models for drug discovery
Coorientador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020 - 2021 Effect of Antiretroviral Therapy on Liver Stage Development of Plasmodium Parasites and Whole Organism Vaccination Against Malaria
Coorientador
Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2021 The impact of African trypanosomes on the infection caused by malaria parasites
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2020 Desenvolvimento de entidades químicas inovadoras para superar o desafio da resistência antimicrobiana
Coorientador
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019 Comparative immunological analyses of whole-sporozoite malaria vaccines
Coorientador
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019 Evaluation of humoral and cellular immune responses to P. berghei-based whole-sporozoite malaria vaccination in rhesus macaques
Coorientador
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2018 - 2019 Targeting p53 with indole-based compounds
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018 Plasmodium berghei liver infection inhibition by host immune response to Trypanosoma brucei
Orientador
Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - 2018 Mechanisms of inhibition of Plasmodium liver infection by amino acid supplementation
Orientador
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 - 2018 New insights into interferon-mediated immune responses elicited by Plasmodium liver stage infection – Unravelling the role of Viperin induction
Coorientador
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018 Cryopreservation of Plasmodium sporozoites for whole-organism vaccination against malaria
Coorientador
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2016 Development of a new in vitro assay for screening malaria transmission blocking compounds
Orientador
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - 2016 Nutrient uptake and metabolism in Plasmodium-infected hepatic cells
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2015 Characterization of a new genetically modified Plasmodium berghei parasite – development of a pre-erythrocytic malaria vaccine
Coorientador
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 Characterization of a new malaria vaccine candidate against Plasmodium vivax using genetically modified rodent Plasmodium parasites
Coorientador
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 Paving a freezing way to defeat malaria
Coorientador
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2013 The reciprocal influence of malaria and sleeping sickness co-infections
Orientador
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2012 Malaria vaccination strategies
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2011 The role of glucose in Plasmodium liver infection
Orientador
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2010 The importance of apoptosis of Plasmodium-infected cells in the generation of immunity against malaria infection
Orientador
2007 - 2008 The influence of bile acids on liver-stage malaria infection
Orientador
Universidade de Lisboa, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2018/03/20 - 2018/03/22 What is Behind a Successful Career?
Encontro
 TwinnToInfect Spring School

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2022/12/20 Impact of adipose tissue colonization by Trypanosoma brucei during infection
Arguente
 Henrique Pedro Pereira da Silva Amaral Machado (Doutoramento)
Universidade de Lisboa, Portugal
2022/12/16 Nanosers microfluidics platform for rapid screening for infectious diseases
Arguente
 Maria João Quitoles de Oliveira (Doutoramento)
Universidade NOVA de Lisboa, Portugal
2022/11/16 Blocking the progression of Plasmodium sporozoites from the skin to the liver
Arguente principal
 Ana Rafaela Azevedo Teixeira (Doutoramento)
Universidade do Porto, Portugal
2022/09/07 Defining molecular pathways in antimalarial drug resistance
Arguente principal
 Miguel João Ferreira da Silva (Doutoramento)
Universidade do Minho, Portugal
2022/04/26 Targeting the transmission stage of malaria parasites by drug- and vaccine-based approaches
Orientador
 Raquel Azevedo (Doutoramento)
Universidade de Lisboa, Portugal
2022/02/04 Impact of SARS-CoV-2 infection in human pregnancy
Arguente principal
 Magda Isabel Barbosa Melro (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/07/27 Large interindividual variations of Plasmodium falciparum growth in in-vitro cultures: Investigation of underlying factors especially related to red blood cells
Arguente principal
 Sara Mateus Mahomed (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/07/22 Protective effect of red blood cell pyruvate kinase deficiency against malaria – is there a role for the host cell membrane?
Arguente principal
 Maria Duarte de Carvalho (Mestrado)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2021/06/18 Unnatural glycopeptides and proteins and their use in antigen detection and immunization
Arguente
 Maria Inês Souda de Albuquerque (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020/12/18 Dissecting Tick Vectors Biosystematics and Symbionts Transmission Potential
Arguente
 Maria João Coimbra Dores (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/07/14 Malária em Cabo Verde
Arguente principal
 Ana Maria Rocha Fernandes Oliveira e Silva (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2020/01/17 Uncovering the UIS4 protein interacting network and its role during the malaria liver stage infection
Arguente
 Viriato M'Bana (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018/11/12 Effect of underlying metabolic diseases, diet and metabolites on the growth of blood stage parasites Plasmodium falciparum
Arguente principal
 Ana Teresa Fernandes Alegre Branco (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/10/25 Studies using transgenic rodent malaria parasites to improve live attenuated malaria vaccines
Arguente principal
 Ahmad Syibli Bin Othman (Doutoramento)
Universiteit Leiden, Países Baixos
2018/10/23 Viral and cell host factors influencing the development of an HCV vaccine candidate
Arguente principal
 Hugo Ricardo L. Soares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/05/04 Development of an innovative real-time assay for antimalarial sensitivity testing
Arguente
 Maria Sousa Rebelo (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2017/02/04 Investigation of immunoprotective sequences of P. falciparum and other species
Vogal
 Anil Kumar (Doutoramento)
Savitrabai Phule University, Índia
2016/12/13 Development and evaluation of a novel and innovative drug sensitivity assay for Plasmodium falciparum
Arguente principal
 Rita Santinho Grenho (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/12/06 Understanding chromatin dynamics during antigenic variation in Trypanosoma brucei
Arguente
 Francisco Maria Aresta Branco (Doutoramento)
2016/01/25 Strategies for improved Adenovirus and PPR vaccine production in different cell lines
Arguente
 Ana Carina Santos Ferreira da Silva (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/12/09 Role of Histone H1 in chromatin and gene expression in the African Trypanosome: broad skills, specific functions
Arguente
 Ana Catarina Dias Pena (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015/11/30 Desenvolvimento de um teste de diagnóstico rápido para a deteção de malária em amostras clínicas
Arguente principal
 Ana Inês Relvinha dos Reis (Mestrado)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/02/03 Role of Plasmodium translationallyrepressed gene products in malaria transmission
Arguente
 Jorge Manuel Santos (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014/10/30 Nanoimunoensaios para a Detecção de Antigénios da Malária em Amostras Clínicas
Arguente principal
 Mariana Amoroso das Neves Romão (Mestrado)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/03/14 FSR quorum sensing: role in Enterococcus faecalis biology & host infection
Arguente principal
 Neuza dos Prazeres Lima Teixeira (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013/12/16 Síntese de novos compostos híbridos com atividade antimalárica
Arguente principal
 Joana Rita Pinto de Magalhães (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/05/15 Proteínas recombinantes de Plasmodium falciparum para deteção de malária por nanoimunoensaios
Arguente principal
 Isabel Bernardo Gonçalves Oliveira Silva (Mestrado)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013/04/03 Uncovering the role of IFNAR1 in experimental cerebral malaria
Arguente principal
 Elizabeth Ann Ball (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012/10/25 Production and characterization of different types of malaria pigment (hemozoin) and their potential use for screening for hemozoin inhibiting drugs
Arguente principal
 Ana Margarida Ferreira Góis (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/02/11 Early detection of the biological and genetic determinants of resistance to artemisin based combination therapy in malaria parasites
Arguente principal
 Louise Rodrigues (Doutoramento)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2010/10/31 Development of Prototype Gold Nanoparticle-Based Immunoassays for the detection of Plasmodium falciparum Hsp70
Arguente principal
 Bassem Samy Guirgis (Mestrado)
The American University in Cairo, Egipto
2005/04/07 Transient protein interactions: The case of pseudoazurin and nitrite reductase
Arguente principal
 Antonietta Impagliazzo (Doutoramento)
Universiteit Leiden, Países Baixos

Arbitragem científica em conferência

Nome da conferência Local da conferência
2023/11/14 - 2023/11/14 7th RedeSaúde Conference Universidade de Lisboa
2022/03/10 - 2022/03/13 AIMS Meeting 2022 - Annual International Meeting of (Bio)Medical Students
2021/11/30 - 2021/11/30 5ª Conferência da redeSAÚDE - A Health Research Agenda towards 2030

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2022/09/20 - 2022/09/20 COVID-19 Therapies Envision Pharma Group Limited, Reino Unido
2022/05/05 - 2022/05/05 COVID-19 Vaccination Policy Advisory Board: Booster Vaccines Pfizer Inc, Estados Unidos
2018 - 2018 Scientific advisor / Consultant for the Law Firm J.E. Dias Costa, Lda., Lisboa, Portugal J.E. Dias Costa, Lda., Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2016 - Atual Lecturer in multiple sessions aimed at children and adolescents (ages 5 to 17 years old). Please consult link. https://miguelprudencio.com/scientific-activities/lectures-for-kids/ (Ensino básico 1º ciclo)
2011 - Atual Advanced teaching in multiple PhD courses. Please consult link. https://miguelprudencio.com/scientific-activities/advanced-teaching/ (Doutoramento)
2008 - Atual Lecturer in multiple Master's courses. Please consult link. https://miguelprudencio.com/scientific-activities/advanced-teaching/ (Mestrado)
2006 - Atual Lecturer in multiple Undergraduate courses. Please consult link. https://miguelprudencio.com/scientific-activities/advanced-teaching/ (Licenciatura)

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2006/01/01 Multiple interviews in newspapers and magazines. Please consult link.

Entrevista / Programa (rádio / tv)

Programa Tema
2008/01/03 - 2024/01/01 Multiple TV and radio interviews. Please consult link. Multiple - Please consult link

Membro de associação

Nome da associação Tipo de participação
2019 - Atual Academia das Ciências de Lisboa

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023/11/01 - 2023/11/12 Prémios ULisboa – RedeSaúde 2023 - 7th RedeSaúde Conference Universidade de Lisboa, Portugal
2023/06/01 - 2023/06/22 Astra Zeneca Innovate Competition, iMEd 15.0
2023/04/01 - 2023/04/30 French National Research Agency (ANR) call for projects Agence nationale de la recherche, França
2023/02/02 - 2023/02/19 Pfizer Award 2023 Sociedade das Ciências Médicas de Lisboa, Portugal
2022/11/01 - 2022/12/01 Roteiro Nacional de Infraestruturas de Investigação Fundação para a Ciência e a Tecnologia, Portugal
2022/11/01 - 2022/11/30 Maria de Sousa 2022 PhD Fellowships Fundação para a Ciência e a Tecnologia, Portugal
2022/09/01 - 2022/09/30 AstraZeneca Innovate Competition iMed 14.0
2022/06/01 - 2022/06/30 ERC Synergy Grants 2022 European Research Council, Bélgica
2022/04/20 - 2022/04/22 XLVII Annual Meeting of the Portuguese Society for Immunology - Evaluator of oral presentations
2022 - 2022 Baillet Latour Biomedical Award 2022 Fonds Baillet Latour, Bélgica
2021 - 2021 Maria de Sousa 2021 PhD Fellowships Fundação para a Ciência e a Tecnologia, Portugal
2021 - 2021 Fellowships Multidisciplinary Center for Infectious Diseases (MCID Bern) UniBern Forschungsstiftung, Suiça
2020 - 2020 Doctorates 4 COVID-19 PhD Fellowships, FCT Fundação para a Ciência e a Tecnologia, Portugal
2020 - 2020 ERC Consolidator Grant 2020 Call European Research Council, Bélgica
2020 - 2020 Roteiro Nacional de Infraestruturas de Investigação, FCT Fundação para a Ciência e a Tecnologia, Portugal
2019 - 2019 AstraZeneca Innovate Competition iMed 11.0 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2019 Roteiro Nacional de Infraestruturas de Investigação, FCT Fundação para a Ciência e a Tecnologia, Portugal
2018 - 2018 Pfizer Award 2018 Sociedade das Ciências Médicas de Lisboa, Portugal
2018 - 2018 22.º Programa “Educação pela Ciência” - GAPIC Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2017 Grant Awards Medical Research Council, UK Medical Research Council, Reino Unido
2017 - 2017 Project call Agence Nationale pour la Recherche, France Agence Thematique de Recherche en Sciences de la Sante, Argélia
2017 - 2017 Everis Award 2017 Everis, Espanha
2017 - 2017 FCT Call for PhD Applications Fundação para a Ciência e a Tecnologia, Portugal
2016 - 2016 Everis Award 2016 Everis, Espanha
2014 - 2014 Pfizer Award 2014 Sociedade das Ciências Médicas de Lisboa, Portugal
2014 - 2014 AstraZeneca Innovate Competition Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2012 Education through Science - GAPIC 2012 Universidade de Lisboa Faculdade de Medicina, Portugal
2010 - 2010 Call for project porposals of the Serbian Ministry of Education Republika Srbija Ministarstvo Obrane, Sérvia
2008 - 2008 PhD Applications Fundação para a Ciência e a Tecnologia, Portugal

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2008 - Atual Ad-hoc reviewer for multiple scientific journals. Please consult link. https://miguelprudencio.com/scientific-activities/peer-revision-evaluation/

Tutoria

Tópico Nome do aluno
2022 - Atual Post-doctoral researcher Akriti Srivastava
2021 - Atual Post-doctoral researcher Andreia Mósca
2018 - Atual Post-doctoral researcher Helena Nunes-Cabaço
2017 - Atual Post-doctoral researcher Diana Fontinha
2012 - Atual Multiple PhD students. Please consult link https://miguelprudencio.com/scientific-activities/supervision-examination/
2008 - Atual Multiple undergraduate students. Please consult link. https://miguelprudencio.com/scientific-activities/supervision-examination/
2008 - Atual Multiple research assistants. Please consult link. https://miguelprudencio.com/scientific-activities/supervision-examination/
2008 - Atual Multiple Master's students. Please consult link. https://miguelprudencio.com/scientific-activities/supervision-examination/
2017 - 2021 Post-doctoral researcher Patrícia Meireles
2012 - 2021 Post-doctoral researcher António Mendes
2015 - 2016 Post-doctoral researcher Cláudia Marques
2013 - 2015 Post-doctoral researcher Marija Markovic
2013 - 2015 Post-doctoral researcher Jorge Manuel Santos
2012 - 2015 Post-doctoral researcher Inês Gomes
2012 - 2014 Post-doctoral researcher Cláudia Sá e Cunha
2011 - 2013 Post-doctoral researcher Filipa P. da Cruz
Distinções

Prémio

2023 Universidade de Lisboa / Caixa Geral de Depósitos Award. First prize in Health Sciences section.
Universidade de Lisboa, Portugal
2021 Honorary Mention - Universidade de Lisboa / Caixa Geral de Depósitos Award
Universidade de Lisboa, Portugal

Caixa Geral de Depositos, Portugal
2020 Pfizer / SCML Award for Clinical Research
Pfizer Portugal, Portugal
2020 Honorary Mention - Universidade de Lisboa / Caixa Geral de Depósitos Award
Universidade de Lisboa, Portugal

Caixa Geral de Depositos, Portugal
2014 EVERIS Entrepreneurs Award
Everis, Espanha
2013 National BES Innovation Contest
Banco Espírito Santo e Comercial de Lisboa, Portugal
2013 Building Global Innovators
ISCTE-IUL MIT-Portugal Venture Competition, Portugal
2008 Amélia da Silva de Mello Award for Health Sciences
José de Mello Saúde, Portugal
2007 CESPU International Research Award
2004 Maria Curie Reintegration Grant
2001 Marie Curie Fellowship

Título

2020 Paul Harris Fellow (PHF) Recognition
Rotary Clube de Oeiras, R.I. 22745, Portugal
2019 Invited Member of Academia das Ciências de Lisboa