Dezso David, graduated in Veterinary Medicine at Technical University of Lisbon Portugal, in 1984, completed a post-graduation in Molecular Biology “International Training Course on Selected Topics of Modern Biology” at Biological Research Centre of the Hungarian Academy of Science, Szeged Hungary, in 1987, and obtained his PhD in Biomedical Sciences at University of Porto, in 1999. Since 1999, he is an Auxiliary Researcher at the Department of Huma Genetics, National Health Institute Doutor Ricardo Jorge, Lisbon, Portugal. Until 2007, he was the PI of the Hemophilias and Thrombophilias Research Group aiming the identification of the molecular bases, pathogenesis, diagnosis as well as prevention of coagulopathies (hemophilia A, B, C and deficiencies of F7 and von Willebrand disease type II N), of hereditary thrombophilias (Protein S alpha, Protein C, SERPINC1 or AT3), of thrombotic risk factors and some X-liked pathologies, in Portugal. In early 80s, as graduate student, he performed cell fusion to study the premature chromosome condensation. Since that time, he was fascinated by this effect and in general by chromosomal rearrangements. Presently, they observed a somehow comparable mechanism leading to chromothripsis in probands with genomic disorders. Since the late 90’s his research has been focused on chromosomal rearrangements. Soon after the introduction of the concept of Genomic Disorders by James R Lupski, he formed the Genomic Disorders Research Group, that his leading since then. His main objective has been to capitalize naturally occurring chromosomal rearrangements as landmarks for disease causing genomic elements and for annotation of the human genome. He was also the first in Portugal to carry out mapping, positional cloning and characterization of candidate genes based on chromosomal translocations associated with human diseases and identification of new candidate genes involved in human development and its disorders. He participated as principal investigator, participant and research fellow in eight, three and one research projects, respectively. The most important of these has been the collaborative translational research project entitled Next-Gen Cytogenetics Enters Clinical Care and Annotates the Human Genome with the Harvard Medical School. Recently, he contributed to the: - introduced of whole genomic sequencing-based identification of balanced and unbalanced structural variant (SV) breakpoints; - HPO-based description of the clinical phenotypes; - development of workflows for sequencing data analysis and their clinical assessment; - implementation of Precision Genomic Medicine for Genomic Disorders; - introduction of this approach to prenatal diagnostics of structural variants; - introduced of topologically associated domains-based analysis of structural Variants; and of bioinformatics tools. A large number of genes, disrupted by breakpoints of structural variants or rearrangements, associated to a panoply of phenotypes, have been identified and characterized by his research group. Presently, he is committed to the implementation in clinical practice of a Precision Genomic Medicine-based approach for Genomic Disorders. He was the supervisor of about seven Master students, of several research fellows throughout his career and recently he contributed to teaching in master curses.