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Anabela Fernandes graduated in Biochemistry by the University of Porto in 2003 and completed a PhD degree in Health Sciences by the University of Minho in 2010. The work developed by Anabela Fernandes during his PhD was performed in the Neurosciences domain at ICVS focusing on the study of neurodegerenative diseases. Since 2016, she's a researcher in the Psychological Neuroscience Laboratory (PNL) at the Research Center on Psychology (CIPsi). Her major goal is to combine experimental physical evaluation, neuroimaging methods and molecular markers assessment to comprehensively study the triangular relationship between these three domains through aging. She is also interested in the study of the pathologic mechanism of neurodegenerative disorders as well as rehabilitation strategies for age-related cognitive and motor decline.
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Identificação

Identificação pessoal

Nome completo
Anabela Silva Fernandes

Nomes de citação

  • Silva-Fernandes, Anabela
  • Fernandes, Anabela

Identificadores de autor

Ciência ID
4F13-76E5-BEE1
ORCID iD
0000-0002-1187-7815

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2018/09/15 - 2024/09/01
Em curso
 Medicina (Mestrado integrado)
Universidade do Porto Faculdade de Medicina, Portugal
2010/12/10
Concluído
 Ciências da Saúde (Doutoramento)
Universidade do Minho, Portugal
"Development and characterization of transgenic mouse models for Machado-Joseph disease" (TESE/DISSERTAÇÃO)
 Aproved with unanimity
2003
Concluído
 Bioquímica- Ramo Especialização em Bioquímica Aplicada (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Characterization of transgenic mice for Machado-Joseph disease" (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/03/13 - Atual Investigador (Investigação) Universidade do Minho, Portugal
Universidade do Minho Centro de Investigação em Psicologia, Portugal
2016/07/01 - 2019/02/28 Pós-doutorado (Investigação) Universidade do Minho Centro de Investigação em Psicologia, Portugal
2013 - 2016 Pós-doutorado (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Laboratório Associado ICVS 3B's, Portugal
2011 - 2012 Assistente de Investigação (carreira) (Investigação) Universidade do Minho, Portugal
Laboratório Associado ICVS 3B's, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - Atual Towards successful cognitive aging: role of the interaction between markers of cardiovascular resistance (CVR), systemic inflammation (IS) and reserve cognitive (RC)
0348_CIE_6_E
Investigador
Universidade do Minho Centro de Investigação em Psicologia, Portugal
 Fundación General CSIC
Em curso
2011 - 2013 Deciphering the role of Aß and TAU among neuronal subpopulations in Alzheimer´s disease network malfunction
PTDC/SAU-NSC/120590/2010
Investigador
Fundação para a Ciência e a Tecnologia

Outro

Designação Financiadores
2016 - Atual - Getting the aging brain to train: a working memory and neurostimulation approach
BIAL 286/16
Investigador
Produções

Publicações

Artigo em revista
  1. Barros, Duarte; Borges-Machado, Flávia; Silva-Fernandes, Anabela; Ribeiro, Oscar; Carvalho, Joana. "Do physical fitness and cognitive function mediate the relationship between basic activities of daily living and quality of life in older adults with dementia?". Quality of Life Research (2023): http://dx.doi.org/10.1007/s11136-023-03570-3.
    Publicado • 10.1007/s11136-023-03570-3
  2. Teixeira-Santos, Ana C.; Gomes, Leandro; Pereira, Diana R.; Ribeiro, Fabiana; Silva-Fernandes, Anabela; Federspiel, Carine; Steinmetz, Jean-Paul; Leist, Anja K.. "The MEDITAGING study: protocol of a two-armed randomized controlled study to compare the effects of the mindfulness-based stress reduction program against a health promotion program in older migrants in Luxembourg". BMC Public Health 23 1 (2023): http://dx.doi.org/10.1186/s12889-023-17387-9.
    10.1186/s12889-023-17387-9
  3. Irwin, Courtney L.; Coelho, Patrícia S.; Kluwe-Schiavon, Bruno; Silva-Fernandes, Anabela; Gonçalves, Óscar F.; Leite, Jorge; Carvalho, Sandra. "Non-pharmacological treatment-related changes of molecular biomarkers in major depressive disorder: A systematic review and meta-analysis". International Journal of Clinical and Health Psychology 23 3 (2023): 100367. http://dx.doi.org/10.1016/j.ijchp.2023.100367.
    10.1016/j.ijchp.2023.100367
  4. Sabot, Philippe; Di Martino, Carla; Moroni, Christine; Pentini, Anna Aluffi; Pabjan, Barbara; Machado, Maria Manuela Pereira; Katkoniene, Agata; et al. "Reconsidering frailty from a human and social sciences standpoint: towards an interdisciplinary approach to vulnerability". Age and Ageing 52 5 (2023): http://dx.doi.org/10.1093/ageing/afad064.
    10.1093/ageing/afad064
  5. Anabela Silva-Fernandes. "Processing speed mediates the association between physical activity and executive functioning in elderly adults". Frontiers in Psychology 13 (2022): http://dx.doi.org/10.3389/fpsyg.2022.958535.
    10.3389/fpsyg.2022.958535
  6. Silva-Fernandes, Anabela. "A Structural Equation Model of Self-Regulation and Healthy Habits as an Individual Protective Tool in the Context of Epidemics–Evidence From COVID-19". Frontiers in Psychology 12 (2021): http://dx.doi.org/10.3389/fpsyg.2021.696813.
    10.3389/fpsyg.2021.696813
  7. Silva-Fernandes, Anabela. "Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease". (2018): http://dx.doi.org/10.1007/s12035-018-1062-4.
    10.1007/s12035-018-1062-4
  8. Silva-Fernandes, Anabela. "Neuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3". (2018): http://dx.doi.org/10.1002/mds.27292.
    10.1002/mds.27292
  9. Duarte-Silva, S.; Silva-Fernandes, A.; Neves-Carvalho, A.; Soares-Cunha, C.; Teixeira-Castro, A.; Maciel, P.. "Combined therapy with m-TOR-dependent and -independent autophagy inducers causes neurotoxicity in a mouse model of Machado-Joseph disease". Neuroscience 313 (2016): 162-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949481661&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2015.11.030
  10. Chatterjee A; Saha S; Chakraborty A; Silva-Fernandes A; Mandal SM; Neves-Carvalho A; Liu Y; et al. "The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis.". (2015): http://europepmc.org/abstract/med/25633985.
    10.1371/journal.pgen.1004749
  11. Neves-Carvalho A; Logarinho E; Freitas A; Duarte-Silva S; Costa Mdo C; Silva-Fernandes A; Martins M; et al. "Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.". (2015): http://europepmc.org/abstract/med/25143392.
    10.1093/hmg/ddu422
  12. Gao R; Liu Y; Silva-Fernandes A; Fang X; Paulucci-Holthauzen A; Chatterjee A; Zhang HL; et al. "Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3.". (2015): http://europepmc.org/abstract/med/25590633.
    10.1371/journal.pgen.1004834
  13. Esteves, S.; Duarte-Silva, S.; Naia, L.; Neves-Carvalho, A.; Teixeira-Castro, A.; Rego, A.C.; Silva-Fernandes, A.; Maciel, P.. "Limited effect of chronic valproic acid treatment in a mouse model of Machado-Joseph disease". PLoS ONE 10 10 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84949591193&partnerID=MN8TOARS.
    10.1371/journal.pone.0141610
  14. Vieira, J.P.; Lopes, F.; Silva-Fernandes, A.; Sousa, M.V.; Moura, S.; Sousa, S.; Costa, B.M.; et al. "Variant Rett syndrome in a girl with a pericentric X-chromosome inversion leading to epigenetic changes and overexpression of the MECP2 gene". International Journal of Developmental Neuroscience 46 (2015): 82-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940047811&partnerID=MN8TOARS.
    10.1016/j.ijdevneu.2015.07.010
  15. Teixeira-Castro, A.; Jalles, A.; Esteves, S.; Kang, S.; Da Silva Santos, L.; Silva-Fernandes, A.; Neto, M.F.; et al. "Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease". Brain 138 11 (2015): 3221-3237. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947806720&partnerID=MN8TOARS.
    10.1093/brain/awv262
  16. Duarte-Silva, S.; Neves-Carvalho, A.; Soares-Cunha, C.; Teixeira-Castro, A.; Oliveira, P.; Silva-Fernandes, A.; Maciel, P.. "Lithium Chloride Therapy Fails to Improve Motor Function in a Transgenic Mouse Model of Machado-Joseph Disease". The Cerebellum (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84905553639&partnerID=MN8TOARS.
    10.1007/s12311-014-0589-9
  17. Ramos, A.; Kazachkova, N.; Silva, F.; Maciel, P.; Silva-Fernandes, A.; Duarte-Silva, S.; Santos, C.; Lima, M.. "Differential mtDNA Damage Patterns in a Transgenic Mouse Model of Machado-Joseph Disease (MJD/SCA3)". Journal of Molecular Neuroscience (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903683796&partnerID=MN8TOARS.
    10.1007/s12031-014-0360-1
  18. Silva-Fernandes, A.; Duarte-Silva, S.; Neves-Carvalho, A.; Amorim, M.; Soares-Cunha, C.; Oliveira, P.; Thirstrup, K.; Teixeira-Castro, A.; Maciel, P.. "Chronic Treatment with 17-DMAG Improves Balance and Coordination in A New Mouse Model of Machado-Joseph Disease". Neurotherapeutics 11 2 (2014): 433-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899493975&partnerID=MN8TOARS.
    10.1007/s13311-013-0255-9
  19. Kazachkova, N.; Raposo, M.; Montiel, R.; Cymbron, T.; Bettencourt, C.; Silva-Fernandes, A.; Silva, S.; MacIel, P.; Lima, M.. "Patterns of mitochondrial DNA damage in blood and brain tissues of a transgenic mouse model of machado-joseph disease". Neurodegenerative Diseases 11 4 (2013): 206-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876420658&partnerID=MN8TOARS.
    10.1159/000339207
  20. Temudo, T.; Santos, M.; Ramos, E.; Dias, K.; Vieira, J.P.; Moreira, A.; Calado, E.; et al. "Rett syndrome with and without detected MECP2 mutations: An attempt to redefine phenotypes". Brain and Development 33 1 (2011): 69-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650306582&partnerID=MN8TOARS.
    10.1016/j.braindev.2010.01.004
  21. Pinho, T.; Silva-Fernandes, A.; Bousbaa, H.; MacIel, P.. "Mutational analysis of MSX1 and PAX9 genes in Portuguese families with maxillary lateral incisor agenesis". European Journal of Orthodontics 32 5 (2010): 582-588. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957771535&partnerID=MN8TOARS.
    10.1093/ejo/cjp155
  22. Silva-Fernandes, A.; Costa, M.D.C.; Duarte-Silva, S.; Oliveira, P.; Botelho, C.M.; Martins, L.; Mariz, J.A.; et al. "Motor uncoordination and neuropathology in a transgenic mouse model of Machado-Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products". Neurobiology of Disease 40 1 (2010): 163-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955842264&partnerID=MN8TOARS.
    10.1016/j.nbd.2010.05.021
  23. Silva-Fernandes, A.; Oliveira, P.; Sousa, N.; Maciel, P.. "Motor and behavioural abnormalities associated with persistent spontaneous epilepsy in the fvb/n mouse strain". Scandinavian Journal of Laboratory Animal Science 37 3 (2010): 213-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051901783&partnerID=MN8TOARS.
  24. Santos, M.; Summavielle, T.; Teixeira-Castro, A.; Silva-Fernandes, A.; Duarte-Silva, S.; Marques, F.; Martins, L.; et al. "Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome". Neuroscience 170 2 (2010): 453-467. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956186732&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2010.07.010
  25. Santos, M.; Silva-Fernandes, A.; Oliveira, P.; Sousa, N.; Maciel, P.. "Evidence for abnormal early development in a mouse model of Rett syndrome". Genes, Brain and Behavior 6 3 (2007): 277-286. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247106769&partnerID=MN8TOARS.
    10.1111/j.1601-183X.2006.00258.x
Poster em conferência
  1. Ana Carolina Teixeira Santos; Silva-Fernandes, Anabela; Couto-Pereira, Natividade; Nobre, Clarisse; Sampaio, Adriana. "Working memory training associated with tDCS increases salivary IGF-1 levels in older adults". Trabalho apresentado em XIII Congreso de la Sociedad Española de Psicofisiología y Neurociencia Cognitiva y Afectiva - SEPNECA 2023, 2023.
  2. FERREIRA, MARISA M.; Sousa, Sónia S.; Gomes, Inês; Torres, Leonor; Ramalho, Miguel; Carvalho, Joana; Sampaio, Adriana; Silva-Fernandes, Anabela. "Physical Activity Promotes Primary Motor Cortex Neuroplasticity over the Course of Aging". 2022.
  3. Silva-Fernandes, Anabela; Cruz, Sara; Sousa, Sónia; FERREIRA, MARISA M.; Gomes, Mariana; Pereira, Diana; Marques, Luís; Carvalho, Joana; Sampaio, Adriana. Autor correspondente: Silva-Fernandes, Anabela. "Physical activity differentiates attention, processing speed and memory performance in elderly adults". Trabalho apresentado em INTERNATIONAL CONGRESS "PROMOTING BRAIN HEALTH THROUGH EXERCISE ACROSS THE LIFESPAN', 2021.
  4. Santos, M; Teixeira-Castro, Andreia; Silva-Fernandes, Anabela; Tavares, Hugo; Sousa, Nuno; Maciel, Patrícia. "Absence of MeCP2 increases postnatal dentate gyrus cell proliferation in a mouse model of Rett syndrome.". Trabalho apresentado em 6th FENS Forum of European Neuroscience, 2008.
Relatório
  1. Courtney L. Irwin; Patrícia S. Coelho; Bruno Kluwe-Schiavon; Anabela Silva-Fernandes; Óscar F. Gonçalves; Jorge Leite; Sandra Carvalho. 2021. Treatment-related changes of molecular biomarkers in major depressive disorder: a systematic review and meta-analysis. https://doi.org/10.37766/inplasy2021.10.0105.
    10.37766/inplasy2021.10.0105
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019 - 2020 Cognitive, structural and physical effects of a multicomponent exercise intervention in older adults - A pilot study.
Orientador de Marisa Mota Ferreira
 Master in Applied Psichology (Mestrado)
Universidade do Minho Escola de Psicologia, Portugal
2018 - 2019 Exploring the impact of physical activity on the healthy aging brain: a volumetric study
Coorientador
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09 - 2018/10 Effect of physical fitness on cognitive functions in healthy young and old adults. (October 2018)
Orientador
Universidade do Minho Escola de Psicologia, Portugal
2016 - 2018 Association between executive funciton, physical activity and aerobic fitness in healthy elderly adults.
Coorientador
 Master Physical Activity for the Elderly (Mestrado)
Universidade do Porto Faculdade de Desporto, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2019/10/31 Neurocognitive Rehabilitation combined with Transcranial Direct Current Stimulation in aphasia
Arguente principal
 Juliana Rute Ribeiro Rocha. (Mestrado)
Universidade do Minho Centro de Investigação em Psicologia, Portugal
2019/10/29 Transcranial Direct Current Stimulation Combined with Neurocognitive Training in Chronic Aphasia
Arguente principal
 Sofia Carolina Santos Ferreira. (Mestrado)
Universidade do Minho Centro de Investigação em Psicologia, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/02 - 2020/06 Professor of the module 4 of the curricular unit "Diversidade na Psicologia" Universidade do Minho Escola de Psicologia, Portugal
2019/09 - 2020/01 Professor at the curricular unit of Introduction of Neurosciences (Mestrado integrado) Universidade do Minho Escola de Psicologia, Portugal

Membro de associação

Nome da associação Tipo de participação
2022 - Atual le COVERAGE International Network Researcher

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019/05 - Atual Management Committee of COST Action: Research Innovation and Sustainable Pan-European Network in Peripartum Depression Disorder-Riseup-PPD CA18138
Membro
Distinções

Prémio

2013 Best poster presentation