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Prof. Vincenzo Crunelli (ORCID iD: 0000-0001-7154-9752) is recognized as a world-leader in the field of cellular, molecular and network mechanisms underlying cortico-thalamic function in sleep and ASs. His interest in astrocytes and astrocyte-neuron signalling led his group to be the first to show that astrocyte can signal to neurons in the absence of neuronal firing and to demonstrate GAT1 dysfunction in ASs by directly recording this transporter current in thalamic astrocytes. Moreover, he was one of the first to report activation of astrocytes by GABA-B receptors. Prof. Crunelli has published >160 peer-reviewed papers, including seminal discoveries reported in Nature, Nature Medicine, Nature Neuroscience, and Neuron (total citations: ~13,000; h factor: 61). He is a member of the Editorial Board of a number of neuroscience journals and was the Editor-in-Chief of the Journal of Neuroscience Methods from 1991 to 2018. Over the last 40 years, his research has been supported by many national and international grants as the only investigator (including awards from the NIH (USA), the MRC (UK), Epilepsy Research UK and 4 five-year Programme Grants from the Wellcome Trust), totalling over GBP £15M. He has also received financial support from multi-investigators grants, including a Wellcome Trust Strategic Award and 3 EU grants (for one of which he was the Co-ordinator). He has served as a member of many grant-awarding committees, including the EU, Wellcome Trust and MRC. Prof. Crunelli has supervised to successful completion 23 PhD and 8 MSc students. Moreover, he was instrumental in securing a large grant from the Wellcome Trust (GBP £2.5M) which allowed Cardiff University to set up a 4-year PhD Programme in Integrative Neuroscience, which he has run as the Director for 8 years and has enrolled >30 students. Some of the PhD students and the postdocs he has supervised over the years now hold prominent faculty positions at Stanford University, Brisbane University and Sorbonne University as well as director-level jobs in industry . Furthermore, the EU Erasmus+ programme Prof. Crunelli has supervised many undergraduate and postgraduate students and young researchers. At present, Prof. Crunelli’s research group includes 2 postdocs, 3 PhD students and 1 MSc student (female-male ratio = 2.0) and is supported by grants from the Wellcome Trust, Epilepsy Research UK, Wales Health Board for Clinical Research, Malta Science and Technology Fund and EU. The current research facilities of his lab include a 2-photon laser scanning microscope (equipped with two lasers for simultaneous imaging and uncaging) for in vitro and in vivo experiments, a dedicated fluorescence microscope for immunohistochemical analysis (equipped with Neurolucida software), 3 patch-clamp recording set-ups, a suite for simultaneous EEG recordings in 4 freely-moving animals, one set-up for single neurons electrical recordings in large neuronal assemblies using silicone probes and equipment for optogenetic stimulations and direct/reverse microdialysis.
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Identificação

Identificação pessoal

Nome completo
Vincenzo Crunelli

Nomes de citação

  • Crunelli, Vincenzo

Identificadores de autor

Ciência ID
4E1D-A063-A7E4
ORCID iD
0000-0001-7154-9752
Formação
Grau Classificação
1979 - 1979
Concluído
 Postdoctoral Research Assistant (Postgraduate Certificate)
Cambridge University Hospitals Neurosciences, Reino Unido
1976 - 1978
Concluído
 Postdoctoral Research Assistant, (Postgraduate Certificate)
Especialização em Neuroscience
Istituto di Ricerche Farmacologiche Mario Negri Dipartimento di Ricerca Neuroscienze, Itália
1974
Concluído
 Pure Chemistry (Dottorato di Ricerca)
Università degli Studi di Catania, Itália
 110/110 Cum Laude
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
1981 - 1984 Investigador Auxiliar (carreira) (Investigação) St. George's Hospital Medical School, Reino Unido
1980 - 1980 Investigador Auxiliar (carreira) (Investigação) Weizmann Institute of Science, Israel

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
1998 - Atual Professor Associado Convidado (Docente Universitário) Université Pierre et Marie Curie, França
1991 - Atual Professor Catedrático (Docente Universitário) Cardiff University School of Biosciences, Reino Unido
1989 - Atual Leitor (Docente Universitário) St. George's Hospital Medical School, Reino Unido
1985 - Atual Leitor (Docente Universitário) St. George's Hospital Medical School, Reino Unido
1989 - 1991 Leitor (Docente Universitário) Institute of Ophthalmology,, Reino Unido
1986 - 1988 Leitor (Docente Universitário) St. George's Hospital Medical School, Reino Unido

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2011 - 2015 Head Neuroscience Division Cardiff University School of Biosciences, Reino Unido
1994 - 1998 Head of Department of Physiology Cardiff University School of Biosciences, Reino Unido
Projetos

Bolsa

Designação Financiadores
2016/12 - 2020/11 Training, research and public awareness in cell biology and pathology of neuroglia
H2020-MSCA-ITN-2016 -722053
 European Commission
2013/10 - 2019/09 DEFINE - Defining endophenotypes from integrated neurosciences
100202/Z/12/Z
 Wellcome Trust
2016/03 - 2019/02 Closed-loop serotonin optogenetic stimulation to suppress epileptic seizures: a therapeutic device
R&I 2013-014
 Malta Council for Science and Technology
2014/08 - 2018/02 A Stem Cell Model to Study Human Cortical Interneuron Function
MR/L020807/1
 Medical Research Council
2010/08 - 2015/07 Mechanism of physiological thalamocortical rhythms.
091882/Z/10/Z - Programme Grant
 Wellcome Trust
2012/06 - 2015/05 Serotoninergic modulation of absence seizures: focus on tonic GABA-A inhibition in the thalamus
P1202
 Epilepsy Research UK
2008/01 - 2012/12 Molecular and cellular investigation of neuron-astroglia interactions: understanding brain function and dysfunction
HEALTH-F2-2007-202167
 European Commission
2009/11 - 2012/10 Spatio-temporal firing dynamics of cortical and thalamic neurons during typical absence seizures
G0900671
 Medical Research Council
2006/01 - 2009/01 Neuronal thalamic gap junctions: identity, location and role in slow EEG rhythms of (patho)physiological states
078403/B/05/Z
 Wellcome Trust
2003/10 - 2008/12 Cellular thalamic mechanisms under physiological and pathological conditions.
071436/Z/03/Z - Programme Grant
 Wellcome Trust
2006/09 - 2007/06 Multidisciplinary core facility for microscopic image analysis and three-dimensional stereology
BB/D524491/1
 Biotechnology and Biological Sciences Research Council
2001/09 - 2005/07 Electrophysiological Action of GHB in Brain Reward Areas
R21DA014830
 National Institute on Drug Abuse
1993/03 - 1998/02 Mechanisms underlying low- and high-frequency oscillatory activities in thalamic cells
037089/Z/92/Z/WRE/JL - Programme Grant
 Wellcome Trust
Produções

Publicações

Artigo em revista
  1. Atherton, Zoe; Nagy, Olivér; Barcsai, Lívia; Sere, Péter; Zsigri, Nikolett; Földi, Tamás; Gellért, Levente; et al. "Higher-order thalamic nuclei facilitate the generalization and maintenance of spike-and-wave discharges of absence seizures". Neurobiology of Disease 178 (2023): 106025. http://dx.doi.org/10.1016/j.nbd.2023.106025.
    Publicado • 10.1016/j.nbd.2023.106025
  2. McCafferty, Cian; Gruenbaum, Benjamin F.; Tung, Renee; Li, Jing-Jing; Zheng, Xinyuan; Salvino, Peter; Vincent, Peter; et al. "Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-022-35535-4.
    Publicado • 10.1038/s41467-022-35535-4
  3. Roebber, Jennifer K.; Lewis, Penelope A.; Crunelli, Vincenzo; Navarrete, Miguel; Hamandi, Khalid. "Effects of Anti-Seizure Medication on Sleep Spindles and Slow Waves in Drug-Resistant Epilepsy". Brain Sciences 12 10 (2022): 1288. http://dx.doi.org/10.3390/brainsci12101288.
    Submetido • 10.3390/brainsci12101288
  4. De Deurwaerdère, Philippe; Casarrubea, Maurizio; Cassar, Daniel; Radic, Manuela; Puginier, Emilie; Chagraoui, Abdeslam; Crescimanno, Giuseppe; Crunelli, Vincenzo; Di Giovanni, Giuseppe. "Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in Genetic Absence Epilepsy Rats From Strasbourg and Non-epileptic Control Rats". Frontiers in Cellular Neuroscience 16 (2022): http://dx.doi.org/10.3389/fncel.2022.886033.
    Publicado • 10.3389/fncel.2022.886033
  5. Cassar, Daniel; Radic, Manuela; Casarrubea, Maurizio; Crunelli, Vincenzo; Di Giovanni, Giuseppe. "The effect of cannabinoid receptor agonist WIN 55,212–2 on anxiety-like behavior and locomotion in a genetic model of absence seizures in the elevated plus-maze". CNS Neuroscience & Therapeutics 28 8 (2022): 1268-1270. http://dx.doi.org/10.1111/cns.13848.
    Publicado • 10.1111/cns.13848
  6. Sere, Péter; Zsigri, Nikolett; Raffai, Timea; Furdan, Szabina; Gyori, Fanni; Crunelli, Vincenzo; Lorincz, Magor L.. "Activity of the Lateral Hypothalamus during Genetically Determined Absence Seizures". International Journal of Molecular Sciences 22 17 (2021): 9466. http://dx.doi.org/10.3390/ijms22179466.
    Publicado • 10.3390/ijms22179466
  7. Iacone, Yasmine; Morais, Tatiana P.; David, François; Delicata, Francis; Sandle, Joanna; Raffai, Timea; Parri, Harri Rheinallt; et al. "Systemic administration of ivabradine, a hyperpolarization-activated cyclic nucleotide-gated channel inhibitor, blocks spontaneous absence seizures". Epilepsia 62 7 (2021): 1729-1743. http://dx.doi.org/10.1111/epi.16926.
    Publicado • 10.1111/epi.16926
  8. Gabriele Deidda; Crunelli, Vincenzo; Giuseppe Di Giovanni. "5-HT/GABA interaction in epilepsy". Progress in Brain Research (2021):
    Publicado
  9. Kimberly Goodspeed; Eduardo Pérez-Palma; Sumaiya Iqbal; Dominique Cooper; Annalisa Scimemi; Crunelli, Vincenzo; Arthur J Campbell ; et al. "Current knowledge of SLC6A1-related neurodevelopmental disorders". Brain Commun (2020):
    Publicado
  10. Crunelli, Vincenzo; Magor L Lorincz; Cian McCafferty; Régis C Lambert; Nathalie Leresche; Giuseppe Di Giovanni; François David. "Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures". Brain (2020):
    Publicado
  11. Armada-Moreira, Adam; Gomes, Joana I.; Pina, Carolina Campos; Savchak, Oksana K.; Gonçalves-Ribeiro, Joana; Rei, Nádia; Pinto, Sara; et al. "Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases". Frontiers in Cellular Neuroscience 14 (2020): http://dx.doi.org/10.3389/fncel.2020.00090.
    Submetido • 10.3389/fncel.2020.00090
  12. Davis, Brittany A; David, François; O’Regan, Ciara; Adam, Manal A; Harwood, Adrian J; Crunelli, Vincenzo; Isles, Anthony R. "Impairments in sensory-motor gating and information processing in a mouse model of Ehmt1 haploinsufficiency". Brain and Neuroscience Advances 4 (2020): 239821282092864. http://dx.doi.org/10.1177/2398212820928647.
    Publicado • 10.1177/2398212820928647
  13. Baruchin, Liad J.; Ranson, Adam; Good, Mark; Crunelli, Vincenzo. "Absence of Neuronal Response Modulation with Familiarity in Perirhinal Cortex". Neuroscience 394 (2018): 23-29. http://dx.doi.org/10.1016/j.neuroscience.2018.10.020.
    Publicado • 10.1016/j.neuroscience.2018.10.020
  14. Corney, B.P.A.; Widnall, C.L.; Rees, D.J.; Davies, J.S.; Crunelli, V.; Carter, D.A.. "Regulatory Architecture of the Neuronal Cacng2/Tarp¿2 Gene Promoter: Multiple Repressive Domains, a Polymorphic Regulatory Short Tandem Repeat, and Bidirectional Organization with Co-regulated lncRNAs". Journal of Molecular Neuroscience 67 2 (2018): 282-294. http://dx.doi.org/10.1007/s12031-018-1208-x.
    Publicado • 10.1007/s12031-018-1208-x
  15. Corney BPA; Widnall CL; Rees DJ; Davies JS; Crunelli V; Carter DA. "Regulatory Architecture of the Neuronal Cacng2/Tarp¿2 Gene Promoter: Multiple Repressive Domains, a Polymorphic Regulatory Short Tandem Repeat, and Bidirectional Organization with Co-regulated lncRNAs.". Journal of molecular neuroscience : MN (2018): http://europepmc.org/abstract/med/30478755.
    10.1007/s12031-018-1208-x
  16. Baruchin LJ; Ranson A; Good M; Crunelli V. "Absence of Neuronal Response Modulation with Familiarity in Perirhinal Cortex.". Neuroscience (2018): http://europepmc.org/abstract/med/30342199.
    10.1016/j.neuroscience.2018.10.020
  17. Di Giovanni G; Crunelli V; Rizzolatti G. "Interdisciplinary approaches for neuropathology.". CNS neuroscience & therapeutics (2018): http://europepmc.org/abstract/med/30009529.
    10.1111/cns.13004
  18. Di Giovanni, Giuseppe; Crunelli, Vincenzo; Rizzolatti, Giacomo. "Interdisciplinary approaches for neuropathology". CNS Neuroscience & Therapeutics 24 8 (2018): 665-668. http://dx.doi.org/10.1111/cns.13004.
    Publicado • 10.1111/cns.13004
  19. David F; Çarçak N; Furdan S; Onat F; Gould T; Mészáros Á; Di Giovanni G; et al. "Suppression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function in Thalamocortical Neurons Prevents Genetically Determined and Pharmacologically Induced Absence Seizures.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2018): http://europepmc.org/abstract/med/29925625.
    10.1523/JNEUROSCI.0896-17.2018
  20. Bettler B; Crunelli V; Enna SJ. "A tribute to Norman G Bowery.". Neuropharmacology (2018): http://europepmc.org/abstract/med/29782875.
    10.1016/j.neuropharm.2018.05.022
  21. McCafferty, Cian; Connelly, William M.; Celli, Roberta; Ngomba, Richard T.; Nicoletti, Ferdinando; Crunelli, Vincenzo. "Genetic rescue of absence seizures". CNS Neuroscience & Therapeutics 24 8 (2018): 745-758. http://dx.doi.org/10.1111/cns.12858.
    Publicado • 10.1111/cns.12858
  22. McCafferty C; Connelly WM; Celli R; Ngomba RT; Nicoletti F; Crunelli V. "Genetic rescue of absence seizures.". CNS neuroscience & therapeutics (2018): http://europepmc.org/abstract/med/29687641.
    10.1111/cns.12858
  23. McCafferty C; David F; Venzi M; Lorincz ML; Delicata F; Atherton Z; Recchia G; et al. "Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures.". Nature neuroscience (2018): http://europepmc.org/abstract/med/29662216.
    10.1038/s41593-018-0130-4
  24. Bombardi C; Venzi M; Crunelli V; Di Giovanni G. "Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model.". Neuropharmacology (2018): http://europepmc.org/abstract/med/29471054.
    10.1016/j.neuropharm.2018.01.047
  25. Crunelli V; Lorincz ML; Connelly WM; David F; Hughes SW; Lambert RC; Leresche N; Errington AC. "Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity.". Nature reviews. Neuroscience (2018): http://europepmc.org/abstract/med/29321683.
    10.1038/nrn.2017.151
  26. Connelly WM; Crunelli V; Errington AC. "Variable Action Potential Backpropagation during Tonic Firing and Low-Threshold Spike Bursts in Thalamocortical But Not Thalamic Reticular Nucleus Neurons.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2017): http://europepmc.org/abstract/med/28450536.
    10.1523/jneurosci.0015-17.2017
  27. Guo JN; Kim R; Chen Y; Negishi M; Jhun S; Weiss S; Ryu JH; et al. "Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study.". The Lancet. Neurology (2016): http://europepmc.org/abstract/med/27839650.
    10.1016/S1474-4422(16)30295-2
  28. Venzi M; David F; Bellet J; Cavaccini A; Bombardi C; Crunelli V; Di Giovanni G. "Role for serotonin2A (5-HT2A) and 2C (5-HT2C) receptors in experimental absence seizures.". Neuropharmacology (2016): http://europepmc.org/abstract/med/27085605.
    10.1016/j.neuropharm.2016.04.016
  29. Connelly WM; Crunelli V; Errington AC. "Passive Synaptic Normalization and Input Synchrony-Dependent Amplification of Cortical Feedback in Thalamocortical Neuron Dendrites.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2016): http://europepmc.org/abstract/med/27030759.
    10.1523/JNEUROSCI.3836-15.2016
  30. David F; Crunelli V; Leresche N; Lambert RC. "Dynamic Analysis of the Conditional Oscillator Underlying Slow Waves in Thalamocortical Neurons.". Frontiers in Neural Circuits (2016): http://europepmc.org/abstract/med/26941611.
    10.3389/fncir.2016.00010
  31. Avoli M; Crunelli V; Jefferys J. "Preface for methods and models in epilepsy research.". Journal of neuroscience methods (2015): http://europepmc.org/abstract/med/26642969.
    10.1016/j.jneumeth.2015.11.016
  32. Connelly WM; Crunelli V; Errington AC. "The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2015): http://europepmc.org/abstract/med/26609149.
    10.1523/JNEUROSCI.2740-15.2015
  33. Crunelli V; Di Giovanni G. "Differential Control by 5-HT and 5-HT1A, 2A, 2C Receptors of Phasic and Tonic GABAA Inhibition in the Visual Thalamus.". CNS neuroscience & therapeutics (2015): http://europepmc.org/abstract/med/26555767.
    10.1111/cns.12480
  34. Lidster K; Jefferys JG; Blümcke I; Crunelli V; Flecknell P; Frenguelli BG; Gray WP; et al. "Opportunities for improving animal welfare in rodent models of epilepsy and seizures.". Journal of neuroscience methods (2015): http://europepmc.org/abstract/med/26376175.
    10.1016/j.jneumeth.2015.09.007
  35. Lorincz ML; Gunner D; Bao Y; Connelly WM; Isaac JT; Hughes SW; Crunelli V. "A distinct class of slow (~0.2-2 Hz) intrinsically bursting layer 5 pyramidal neurons determines UP/DOWN state dynamics in the neocortex.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2015): http://europepmc.org/abstract/med/25855163.
    10.1523/JNEUROSCI.3603-14.2015
  36. Connelly WM; Laing M; Errington AC; Crunelli V. "The Thalamus as a Low Pass Filter: Filtering at the Cellular Level does Not Equate with Filtering at the Network Level.". Frontiers in neural circuits (2015): http://europepmc.org/abstract/med/26834570.
    10.3389/fncir.2015.00089
  37. Venzi M; Di Giovanni G; Crunelli V. "A critical evaluation of the gamma-hydroxybutyrate (GHB) model of absence seizures.". CNS neuroscience & therapeutics (2014): http://europepmc.org/abstract/med/25403866.
    10.1111/cns.12337
  38. Gould T; Chen L; Emri Z; Pirttimaki T; Errington AC; Crunelli V; Parri HR. "GABA(B) receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid.". Philosophical transactions of the Royal Society of London. Series B, Biological sciences (2014): http://europepmc.org/abstract/med/25225100.
    10.1098/rstb.2013.0607
  39. Crunelli V; David F; Lorincz ML; Hughes SW. "The thalamocortical network as a single slow wave-generating unit.". Current opinion in neurobiology (2014): http://europepmc.org/abstract/med/25233254.
    10.1016/j.conb.2014.09.001
  40. Griemsmann S; Höft SP; Bedner P; Zhang J; von Staden E; Beinhauer A; Degen J; et al. "Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells.". Cerebral cortex (New York, N.Y. : 1991) (2014): http://europepmc.org/abstract/med/25037920.
    10.1093/cercor/bhu157
  41. Taylor H; Schmiedt JT; Carçak N; Onat F; Di Giovanni G; Lambert R; Leresche N; Crunelli V; David F. "Investigating local and long-range neuronal network dynamics by simultaneous optogenetics, reverse microdialysis and silicon probe recordings in vivo.". Journal of neuroscience methods (2014): http://europepmc.org/abstract/med/25004203.
    10.1016/j.jneumeth.2014.06.031
  42. Crunelli V; David F; Leresche N; Lambert RC. "Role for T-type Ca2+ channels in sleep waves.". Pflugers Archiv : European journal of physiology (2014): http://europepmc.org/abstract/med/24578015.
    10.1007/s00424-014-1477-3
  43. Crunelli V; Carmignoto G; Steinhäuser C. "Novel astrocyte targets: new avenues for the therapeutic treatment of epilepsy.". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry (2014): http://europepmc.org/abstract/med/24609207.
    10.1177/1073858414523320
  44. Crunelli V; Di Giovanni G. "Monoamine modulation of tonic GABAA inhibition.". Reviews in the neurosciences (2014): http://europepmc.org/abstract/med/24468610.
    10.1515/revneuro-2013-0059
  45. David F; Schmiedt JT; Taylor HL; Orban G; Di Giovanni G; Uebele VN; Renger JJ; et al. "Essential thalamic contribution to slow waves of natural sleep.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2013): http://europepmc.org/abstract/med/24336724.
    10.1523/JNEUROSCI.3169-13.2013
  46. Connelly WM; Errington AC; Crunelli V. "¿-Hydroxybutyric acid (GHB) is not an agonist of extrasynaptic GABAA receptors.". PloS one (2013): http://europepmc.org/abstract/med/24244421.
    10.1371/journal.pone.0079062
  47. Connelly WM; Errington AC; Di Giovanni G; Crunelli V. "Metabotropic regulation of extrasynaptic GABAA receptors.". Frontiers in neural circuits (2013): http://europepmc.org/abstract/med/24298239.
    10.3389/fncir.2013.00171
  48. Lambert RC; Bessaïh T; Crunelli V; Leresche N. "The many faces of T-type calcium channels.". Pflugers Archiv : European journal of physiology (2013): http://europepmc.org/abstract/med/24043572.
    10.1007/s00424-013-1353-6
  49. Wade J; McDaid L; Harkin J; Crunelli V; Kelso S. "Biophysically based computational models of astrocyte ~ neuron coupling and their functional significance.". Frontiers in computational neuroscience (2013): http://europepmc.org/abstract/med/23675340.
    10.3389/fncom.2013.00044
  50. Yagüe JG; Cavaccini A; Errington AC; Crunelli V; Di Giovanni G. "Dopaminergic modulation of tonic but not phasic GABAA-receptor-mediated current in the ventrobasal thalamus of Wistar and GAERS rats.". Experimental neurology (2013): http://europepmc.org/abstract/med/23562670.
    10.1016/j.expneurol.2013.03.023
  51. Connelly WM; Fyson SJ; Errington AC; McCafferty CP; Cope DW; Di Giovanni G; Crunelli V. "GABAB Receptors Regulate Extrasynaptic GABAA Receptors.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2013): http://europepmc.org/abstract/med/23447590.
    10.1523/JNEUROSCI.4989-12.2013
  52. Hughes S; Crunelli V. "UP states rise from the depths.". Nature neuroscience (2013): http://europepmc.org/abstract/med/23354382.
    10.1038/nn.3313
  53. Crunelli V; Carmignoto G. "New vistas on astroglia in convulsive and non-convulsive epilepsy highlight novel astrocytic targets for treatment.". The Journal of physiology (2012): http://europepmc.org/abstract/med/23230232.
    10.1113/jphysiol.2012.243378
  54. Pirttimaki T; Parri HR; Crunelli V. "Astrocytic GABA transporter GAT-1 dysfunction in experimental absence seizures.". The Journal of physiology (2012): http://europepmc.org/abstract/med/23090943.
    10.1113/jphysiol.2012.242016
  55. Wade J; McDaid L; Harkin J; Crunelli V; Kelso S. "Self-repair in a bidirectionally coupled astrocyte-neuron (AN) system based on retrograde signaling.". Frontiers in computational neuroscience (2012): http://europepmc.org/abstract/med/23055965.
    10.3389/fncom.2012.00076
  56. Errington AC; Hughes SW; Crunelli V. "Rhythmic dendritic Ca2+ oscillations in thalamocortical neurons during slow non-REM sleep-related activity in vitro.". The Journal of physiology (2012): http://europepmc.org/abstract/med/22641775.
    10.1113/jphysiol.2012.232132
  57. Crunelli V; Lorincz ML; Bao Y; Errington AC; Hughes SW. "Erratum to: Activity of cortical and thalamic neurons during the slow (<1 Hz) rhythm in the mouse in vivo.". Pflugers Archiv : European journal of physiology (2012): http://europepmc.org/abstract/PMC/PMC3462960.
    10.1007/s00424-011-1067-6
  58. Wade JJ; McDaid LJ; Harkin J; Crunelli V; Kelso JA. "Bidirectional coupling between astrocytes and neurons mediates learning and dynamic coordination in the brain: a multiple modeling approach.". PloS one (2011): http://europepmc.org/abstract/med/22242121.
    10.1371/journal.pone.0029445
  59. Crunelli V; Errington AC; Hughes SW; Tóth TI. "The thalamic low-threshold Ca²¿ potential: a key determinant of the local and global dynamics of the slow (<1 Hz) sleep oscillation in thalamocortical networks.". Philosophical transactions. Series A, Mathematical, physical, and engineering sciences (2011): http://europepmc.org/abstract/med/21893530.
    10.1098/rsta.2011.0126
  60. Crunelli V; Cope DW; Terry JR. "Transition to absence seizures and the role of GABA(A) receptors.". Epilepsy research (2011): http://europepmc.org/abstract/med/21889315.
    10.1016/j.eplepsyres.2011.07.011
  61. Crunelli V; Lörincz ML; Errington AC; Hughes SW. "Activity of cortical and thalamic neurons during the slow (<1 Hz) rhythm in the mouse in vivo.". Pflugers Archiv : European journal of physiology (2011): http://europepmc.org/abstract/med/21892727.
    10.1007/s00424-011-1011-9
  62. Errington AC; Cope DW; Crunelli V. "Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors.". Advances in pharmacological sciences (2011): http://europepmc.org/abstract/med/21912539.
    10.1155/2011/790590
  63. Hughes SW; Lorincz ML; Blethyn K; Kékesi KA; Juhász G; Turmaine M; Parnavelas JG; Crunelli V. "Thalamic Gap Junctions Control Local Neuronal Synchrony and Influence Macroscopic Oscillation Amplitude during EEG Alpha Rhythms.". Frontiers in psychology (2011): http://europepmc.org/abstract/med/22007176.
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  153. Crunelli V; Leresche N. "A role for GABAB receptors in excitation and inhibition of thalamocortical cells.". Trends in neurosciences (1991): http://europepmc.org/abstract/med/1709527.
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  154. Juhász G; Kékesi K; Emri Z; Soltesz I; Crunelli V. "Sleep-promoting action of excitatory amino acid antagonists: a different role for thalamic NMDA and non-NMDA receptors.". Neuroscience letters (1990): http://europepmc.org/abstract/med/1976237.
    10.1016/0304-3940(90)90586-x
  155. Leresche N; Jassik-Gerschenfeld D; Haby M; Soltesz I; Crunelli V. "Pacemaker-like and other types of spontaneous membrane potential oscillations of thalamocortical cells.". Neuroscience letters (1990): http://europepmc.org/abstract/med/1973275.
    10.1016/0304-3940(90)90497-w
  156. Pirchio M; Lightowler S; Crunelli V. "Postnatal development of the T calcium current in cat thalamocortical cells.". Neuroscience (1990): http://europepmc.org/abstract/med/2255399.
    10.1016/0306-4522(90)90372-b
  157. Crunelli V; Lightowler S; Pollard CE. "A T-type Ca2+ current underlies low-threshold Ca2+ potentials in cells of the cat and rat lateral geniculate nucleus.". The Journal of physiology (1989): http://europepmc.org/abstract/med/2557441.
    10.1113/jphysiol.1989.sp017668
  158. Soltesz I; Lightowler S; Leresche N; Crunelli V. "Optic tract stimulation evokes GABAA but not GABAB IPSPs in the rat ventral lateral geniculate nucleus.". Brain research (1989): http://europepmc.org/abstract/med/2924152.
    10.1016/0006-8993(89)91334-6
  159. Soltesz I; Lightowler S; Leresche N; Crunelli V. "On the properties and origin of the GABAB inhibitory postsynaptic potential recorded in morphologically identified projection cells of the cat dorsal lateral geniculate nucleus.". Neuroscience (1989): http://europepmc.org/abstract/med/2557560.
    10.1016/0306-4522(89)90307-2
  160. Soltesz I; Haby M; Leresche N; Crunelli V. "The GABAB antagonist phaclofen inhibits the late K+-dependent IPSP in cat and rat thalamic and hippocampal neurones.". Brain research (1988): http://europepmc.org/abstract/med/2837311.
    10.1016/0006-8993(88)91275-9
  161. Crunelli V; Haby M; Jassik-Gerschenfeld D; Leresche N; Pirchio M. "Cl- - and K+-dependent inhibitory postsynaptic potentials evoked by interneurones of the rat lateral geniculate nucleus.". The Journal of physiology (1988): http://europepmc.org/abstract/med/3404460.
    10.1113/jphysiol.1988.sp017073
  162. Haby M; Leresche N; Jassik-Gerschenfeld D; Soltesz I; Crunelli V. "[Spontaneous rhythmic depolarization in the principal cells of the lateral geniculate body in vitro: the role of NMDA receptors]". Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie (1988): http://europepmc.org/abstract/med/2830951.
  163. Crunelli V; Leresche N; Parnavelas JG. "Membrane properties of morphologically identified X and Y cells in the lateral geniculate nucleus of the cat in vitro.". The Journal of physiology (1987): http://europepmc.org/abstract/med/3443935.
    10.1113/jphysiol.1987.sp016697
  164. Crunelli V; Leresche N; Hynd JW; Patel NM; Parnavelas JG. "An in vitro slice preparation of the cat lateral geniculate nucleus.". Journal of neuroscience methods (1987): http://europepmc.org/abstract/med/3306171.
    10.1016/0165-0270(87)90053-7
  165. Dinan TG; Crunelli V; Kelly JS. "Neuroleptics decrease calcium-activated potassium conductance in hippocampal pyramidal cells.". Brain research (1987): http://europepmc.org/abstract/med/2884012.
    10.1016/0006-8993(87)91231-5
  166. Crunelli V; Kelly JS; Leresche N; Pirchio M. "The ventral and dorsal lateral geniculate nucleus of the rat: intracellular recordings in vitro.". The Journal of physiology (1987): http://europepmc.org/abstract/med/3309264.
    10.1113/jphysiol.1987.sp016471
  167. Crunelli V; Kelly JS; Leresche N; Pirchio M. "On the excitatory post-synaptic potential evoked by stimulation of the optic tract in the rat lateral geniculate nucleus.". The Journal of physiology (1987): http://europepmc.org/abstract/med/2888880.
    10.1113/jphysiol.1987.sp016472
  168. Crunelli V; Leresche N; Parnavelas JG. "X- and Y-cells identified in the cat lateral geniculate nucleus in vitro.". Brain research (1986): http://europepmc.org/abstract/med/3756488.
    10.1016/0006-8993(86)90238-6
  169. Crunelli V; Segal M. "An electrophysiological study of neurones in the rat median raphe and their projections to septum and hippocampus.". Neuroscience (1985): http://europepmc.org/abstract/med/4010934.
    10.1016/0306-4522(85)90122-8
  170. Crunelli V; Mayer ML. "Mg2+ dependence of membrane resistance increases evoked by NMDA in hippocampal neurones.". Brain research (1984): http://europepmc.org/abstract/med/6388730.
    10.1016/0006-8993(84)90107-0
  171. Crunelli V; Forda S; Kelly JS. "The reversal potential of excitatory amino acid action on granule cells of the rat dentate gyrus.". The Journal of physiology (1984): http://europepmc.org/abstract/med/6379151.
    10.1113/jphysiol.1984.sp015248
  172. Mayer ML; Crunelli V; Kemp JA. "Lithium ions increase action potential duration of mammalian neurons.". Brain research (1984): http://europepmc.org/abstract/med/6704716.
    10.1016/0006-8993(84)91466-5
  173. Crunelli V; Forda S; Brooks PA; Wilson KC; Wise JC; Kelly JS. "Passive membrane properties of neurones in the dorsal raphe and periaqueductal grey recorded in vitro.". Neuroscience letters (1983): http://europepmc.org/abstract/med/6646498.
    10.1016/0304-3940(83)90049-6
  174. Crunelli V; Forda S; Kelly JS. "Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus.". The Journal of physiology (1983): http://europepmc.org/abstract/med/6137561.
    10.1113/jphysiol.1983.sp014829
  175. Crunelli V; Forda S; Collingridge GL; Kelly JS. "Intracellular recorded synaptic antagonism in the rat dentate gyrus.". Nature (1982): http://europepmc.org/abstract/med/6128679.
    10.1038/300450a0
  176. Consolo S; Ladinsky H; Pugnetti P; Fusi R; Crunelli V. "Increase in rat striatal acetylcholine content by bromocriptine: evidence for an indirect dopaminergic action.". Life sciences (1981): http://europepmc.org/abstract/med/7278497.
    10.1016/0024-3205(81)90211-3
  177. Assaf SY; Crunelli V; Kelly JS. "Action of 5-hydroxytryptamine on granule cells in the rat hippocampal slice.". Journal de physiologie (1981): http://europepmc.org/abstract/med/7288654.
  178. Assaf SY; Crunelli V; Kelly JS. "Depolarizing postsynaptic actions of GABA in the rat dentate gyrus.". Advances in biochemical psychopharmacology (1981): http://europepmc.org/abstract/med/7257929.
  179. Mennini T; Pataccini R; Crunelli V; Caccia S; Ballabio M; Samanin R; Garattini S. "Localization of fenfluramine and reserpine in brain regions of rats with extensive degeneration of 5-hydroxytryptaminergic neurons.". The Journal of pharmacy and pharmacology (1980): http://europepmc.org/abstract/med/6105191.
  180. Crunelli V; Bernasconi S; Samanin R. "Effects of d- and 1-fenfluramine on striatal homovanillic acid concentrations in rats after pharmacological manipulation of brain serotonin.". Pharmacological research communications (1980): http://europepmc.org/abstract/med/7190307.
    10.1016/s0031-6989(80)80004-x
  181. Consolo S; Ladinsky H; Tirelli AS; Crunelli V; Samanin R; Garattini S. "Increase in rat striatal acetylcholine content by d-fenfluramine, a serotonin releaser.". Life sciences (1979): http://europepmc.org/abstract/med/231171.
    10.1016/0024-3205(79)90601-5
  182. Pantarotto C; Crunelli V; Lanzoni J; Frigerio A; Quattrone A. "Quantitative determination of carbamazepine and carbamazepine-10,11-epoxide in rat brain areas by multiple ion detection mass fragmentography.". Analytical biochemistry (1979): http://europepmc.org/abstract/med/434455.
    10.1016/s0003-2697(79)80053-6
  183. Crunelli V; Bernasconi S; Samanin R. "Evidence against serotonin involvement in the tonic component of electrically induced convulsions and in carbamazepine anticonvulsant activity.". Psychopharmacology (1979): http://europepmc.org/abstract/med/120546.
    10.1007/bf00431994
  184. Quattrone A; Crunelli V; Samanin R. "Seizure susceptibility and anticonvulsant activity of carbamazepine, diphenylhydantoin and phenobarbital in rats with selective depletions of brain monoamines.". Neuropharmacology (1978): http://europepmc.org/abstract/med/692823.
    10.1016/0028-3908(78)90161-2
Livro
  1. Crunelli V; Leresche N; Cope DW. GABA-A Receptor Function in Typical Absence Seizures. 2012.

Outros

Outra produção
  1. Ehmt1 forebrain haploinsufficiency leads to impaired memory, sensory gating and information processing. 2018. Davis BA; David F; O'Regan C; Adam M; Harwood A; Crunelli V; Isles A. http://europepmc.org/abstract/PPR/PPR18156.
    10.1101/257626
Distinções

Prémio

2012 Learned Society of Wales
2012 Malta Chamber of Scientists
2010 Academy of Medical Sciences
2010 Academia Europaea