???global.info.a_carregar???
My name is Tiago Magalhães and I believe in the power of science and knowledge to make the world a better place. I have a Ph.D in genomics and an EMBA in management of research infrastructures. I am Director of Bioinformatics at Genuity Science, where I built and now oversee a team doing analytics on big data human genetics and research, and the implementation of scalable and reproducible scientific workflows. Words that describe my daily work: leadership, team building, drug discovery, data science, bioinformatics, machine learning, cloud computing/AWS/K8s, Nextflow, resources and infrastructure management, innovation, agile, institutional representation, strategic planning, and financial supervision. Before my current position, I was the executive director at CCMAR, a marine research institute. Before that I studied the genomics of autism, diabetes and bowel cancer; and ancestry analysis: human migrations and admixture. I have a very strong background in biology, namely in animal models, genetic screens, cell biology, microscopy and molecular biology. For over 5 years I was part of the Autism Genome Project (AGP), a large, international genomics consortium I am an expert in R, Python, and the genetics/genomics software. I was founder and CEO of a personalized medicine start-up and adviser to Portuguese genomics and VC companies. I am an expert reviewer for genomics journals and the H2020 European Union programs. I have worked/studied in Portugal, Germany, US, Canada, East-timor, Ireland and Brasil.
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Luís Tiago Ferreira Romero Magalhaes

Nomes de citação

  • Tiago R Magalhaes
  • TR Magalhaes
  • Magalhaes, TR
  • Magalhaes, Tiago R

Identificadores de autor

Ciência ID
4C18-3E76-D12B
ORCID iD
0000-0002-5528-2119

Telefones

Telemóvel
  • 960234462 (Pessoal)

Moradas

  • Rua José Joaquim de Moura, 62, 8000-381, Faro, Faro, Portugal (Pessoal)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Exatas - Ciências da Computação e da Informação - Bioinformática
  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2)
Alemão Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B1) Utilizador independente (B2) Utilizador elementar (A2)
Português (Idioma materno)
Formação
Grau Classificação
2017/09/01 - 2019/03/08
Frequentou
 EMBA — Executive Masters in Management of Research infrastructures (Outros)
Especialização em Management
Università degli Studi di Milano-Bicocca, Itália
1999/11/01 - 2007/01/07
Concluído
 Biologia (Doutoramento)
Especialização em Especialidade: Biologia Celular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

University of California Berkeley, Estados Unidos
"Genetic Analysis of Axon Guidance Mechanisms During Embryonic Development of Drosophila Melanogaster Using Dna Microarrays" (TESE/DISSERTAÇÃO)
 Aprovado por unanimidade com distinção e louvor
1992/01/06 - 1997/08/05
Concluído
 Bioquímica (Licenciatura)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Ruhr-Universität Bochum, Alemanha
"Sekretion Extrazellulärer Lipase von Serratia marcescens: Isolierung und Charakterisierung von Mutanten der Gene lipB und lipD" (TESE/DISSERTAÇÃO)
 14. Tese: 18
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/03 - 2015/09 Investigador Contratado (Investigação) University College Dublin, Irlanda
University College Dublin College of Health Sciences, Irlanda
2011/03 - 2013/03 Investigador visitante (Investigação) Universidade Federal de Minas Gerais, Brasil
2011/04/01 - 2011/12/31 Pós-doutorado (Investigação) University College Dublin College of Health Sciences, Irlanda
2007/09/01 - 2010/06/30 Pós-doutorado (Investigação) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/10 - Atual Director Bioinformatics / VP Bioinformatics Genuity Sciences, Irlanda

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/10 - 2017/09 Diretor Executivo Centro de Ciências do Mar, Portugal
2010/06/01 - 2011/04/30 Technology Transfer Officer Universidade Algarve — Centro Regional Inovação do Algarve (CRIA), Portugal
2006/01/01 - 2007/09/30 Technology Transfer Officer Universidade Algarve — Centro Regional Inovação do Algarve (CRIA), Portugal
Universidade Algarve — Centro Regional Inovação do Algarve (CRIA), Portugal
Produções

Publicações

Artigo em revista
  1. Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, Valentina; et al. "Analysis of shared heritability in common disorders of the brain". Science 360 6395 (2018): eaap8757. http://dx.doi.org/10.1126/science.aap8757.
    10.1126/science.aap8757
  2. McMorrow, Aoibheann M.; Connaughton, Ruth M.; Magalhães, Tiago R.; McGillicuddy, Fiona C.; Hughes, Maria F.; Cheishvili, David; Morine, Melissa J.; et al. "Personalized Cardio-Metabolic Responses to an Anti-Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial". Molecular Nutrition & Food Research 62 10 (2018): 1701008. http://dx.doi.org/10.1002/mnfr.201701008.
    10.1002/mnfr.201701008
  3. Tiago R Magalhaes. "Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia". Molecular Autism 8 1 (2017): http://dx.doi.org/10.1186/s13229-017-0137-9.
    10.1186/s13229-017-0137-9
  4. Weiner, Daniel J; Wigdor, Emilie M; Ripke, Stephan; Walters, Raymond K; Kosmicki, Jack A; Grove, Jakob; Samocha, Kaitlin E; et al. "Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders". Nature Genetics 49 7 (2017): 978-985. http://dx.doi.org/10.1038/ng.3863.
    10.1038/ng.3863
  5. Allen, Nicholas M.; Conroy, Judith; Shahwan, Amre; Lynch, Bryan; Correa, Raony G.; Pena, Sergio D. J.; McCreary, Dara; et al. "Unexplained early onset epileptic encephalopathy: Exome screening and phenotype expansion". Epilepsia 57 1 (2015): e12-e17. http://dx.doi.org/10.1111/epi.13250.
    10.1111/epi.13250
  6. Allen, Nicholas M.; Conroy, Judith; Shahwan, Amre; Lynch, Bryan; Correa, Raony G.; Pena, Sergio D. J.; McCreary, Dara; et al. "Unexplained early onset epileptic encephalopathy: Exome screening and phenotype expansion". Epilepsia 57 1 (2015): e12-e17. http://dx.doi.org/10.1111/epi.13250.
    10.1111/epi.13250
  7. Afshinnekoo, E.; Meydan, C.; Chowdhury, S.; Jaroudi, D.; Boyer, C.; Bernstein, N.; Maritz, J.M.; et al. "Modern Methods for Delineating Metagenomic Complexity". Cell Systems 1 1 (2015): 6-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938303443&partnerID=MN8TOARS.
    10.1016/j.cels.2015.07.007
  8. Morrison, M.A.; Magalhaes, T.R.; Ramke, J.; Smith, S.E.; Ennis, S.; Simpson, C.L.; Portas, L.; et al. "Ancestry of the Timorese: Age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world". Frontiers in Genetics 6 JUL (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940104627&partnerID=MN8TOARS.
    10.3389/fgene.2015.00238
  9. Afshinnekoo, E.; Meydan, C.; Chowdhury, S.; Jaroudi, D.; Boyer, C.; Bernstein, N.; Maritz, J.M.; et al. "Erratum: Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics (Cell Systems (2015) 1 (72-87) )". Cell Systems 1 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84938374976&partnerID=MN8TOARS.
    10.1016/j.cels.2015.07.006
  10. Afshinnekoo, E.; Meydan, C.; Chowdhury, S.; Jaroudi, D.; Boyer, C.; Bernstein, N.; Maritz, J.M.; et al. "Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics". Cell Systems 1 1 (2015): 72-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925104897&partnerID=MN8TOARS.
    10.1016/j.cels.2015.01.001
  11. Moreira, D.P.; Griesi-Oliveira, K.; Bossolani-Martins, A.L.; Lourenço, N.C.V.; Takahashi, V.N.O.; Da Rocha, K.M.; Moreira, E.S.; et al. "Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in autism spectrum disorder Brazilian individuals with and without epilepsy". PLoS ONE 9 9 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84907573586&partnerID=MN8TOARS.
    10.1371/journal.pone.0107705
  12. Hadley, D.; Wu, Z.-L.; Kao, C.; Kini, A.; Mohamed-Hadley, A.; Thomas, K.; Vazquez, L.; et al. "The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism". Nature Communications 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84902504072&partnerID=MN8TOARS.
    10.1038/ncomms5074
  13. Pinto, D.; Delaby, E.; Merico, D.; Barbosa, M.; Merikangas, A.; Klei, L.; Thiruvahindrapuram, B.; et al. "Convergence of genes and cellular pathways dysregulated in autism spectrum disorders". American Journal of Human Genetics 94 5 (2014): 677-694. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899918742&partnerID=MN8TOARS.
    10.1016/j.ajhg.2014.03.018
  14. Durso, D.F.; Bydlowski, S.P.; Hutz, M.H.; Suarez-Kurtz, G.; Magalhães, T.R.; Pena, S.D.J.. "Association of genetic variants with self-assessed color categories in Brazilians". PLoS ONE 9 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84897439499&partnerID=MN8TOARS.
    10.1371/journal.pone.0083926
  15. Magalhães, T.R.; Casey, J.P.; Conroy, J.; Regan, R.; Fitzpatrick, D.J.; Shah, N.; Sobral, J.; Ennis, S.. "HGDP and HapMap Analysis by Ancestry Mapper Reveals Local and Global Population Relationships". PLoS ONE 7 11 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84870032185&partnerID=MN8TOARS.
    10.1371/journal.pone.0049438
  16. Anney, R.; Klei, L.; Pinto, D.; Almeida, J.; Bacchelli, E.; Baird, G.; Bolshakova, N.; et al. "Individual common variants exert weak effects on the risk for autism spectrum disorders". Human Molecular Genetics 21 21 (2012): 4781-4792. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867829870&partnerID=MN8TOARS.
    10.1093/hmg/dds301
  17. Casey, J.P.; Magalhaes, T.; Conroy, J.M.; Regan, R.; Shah, N.; Anney, R.; Shields, D.C.; et al. "A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder". Human Genetics 131 4 (2012): 565-579. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860879137&partnerID=MN8TOARS.
    10.1007/s00439-011-1094-6
  18. Pinto, D.; Pagnamenta, A.T.; Klei, L.; Anney, R.; Merico, D.; Regan, R.; Conroy, J.; et al. "Functional impact of global rare copy number variation in autism spectrum disorders". Nature 466 7304 (2010): 368-372. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954657070&partnerID=MN8TOARS.
    10.1038/nature09146
  19. Anney, R.; Klei, L.; Pinto, D.; Regan, R.; Conroy, J.; Magalhaes, T.R.; Correia, C.; et al. "A genome-wide scan for common alleles affecting risk for autism". Human Molecular Genetics 19 20 (2010): 4072-4082. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957735529&partnerID=MN8TOARS.
    10.1093/hmg/ddq307
  20. Weiss, L.A.; Arking, D.E.; Daly, M.J.; Chakravarti, A.; Brune, C.W.; West, K.; O'Connor, A.; et al. "A genome-wide linkage and association scan reveals novel loci for autism". Nature 461 7265 (2009): 802-808. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349956425&partnerID=MN8TOARS.
    10.1038/nature08490
  21. Magalhães, T.R.; Palmer, J.; Tomancak, P.; Pollard, K.S.. "Transcriptional control in embryonic Drosophila midline guidance assessed through a whole genome approach". BMC Neuroscience 8 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34548101343&partnerID=MN8TOARS.
    10.1186/1471-2202-8-59
  22. Aberle, H.; Haghighi, A.P.; Fetter, R.D.; McCabe, B.D.; Magalhães, T.R.; Goodman, C.S.. "Wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila". Neuron 33 4 (2002): 545-558. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037075207&partnerID=MN8TOARS.
    10.1016/S0896-6273(02)00589-5
  23. Graca, L.; Nery, S.; Bettencourt Dias, M.; Magalhaes, T.. "Weak euro hits PhDs too [2]". Nature 408 6812 (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034735796&partnerID=MN8TOARS.
Atividades

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2013/01/03 - 2021 Expert reviewer para a União Europeia, incluindo H2020 grants, Madame Curie-Sklodowska, IMI (Innovative Medicine Initiative) e outros.
Avaliador
 Horizon 2020 European Innovation Council Fast Track to Innovation, Bélgica