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Ricardo Neves has a D.Phil. in Clinical Laboratory Sciences at the University of Oxford (UK); a M.Phil. in Toxicology and a M.Sci. in Biology at the University of Aveiro (Portugal). The central directions of RN's laboratory are to explore the link between metabolism > transcription > alternative splicing > stem cell fate decision/ disease. This central line is explored with an approach grounded on basic biochemistry mechanisms and the emphasis on translational applications in the cell therapy and tissue engineering area. During the D.Phil., RN found that mitochondria (particularly ATP production) are important extrinsic modulators of transcription (highlighted Faculty1000). Following this observation a model of the impact of this link between mitochondria and transcription capacity in stem cell fate decision was done. These two studies were based on experimental results obtained by RN during the DPhil and Post-doc work at the University of Oxford. This work bridges the scientific areas of Genome Regulation and Gene Expression with Metabolism and Systems Biology. This line of research was kept after moving to Portugal through close collaborations with DPhil-supervisor Francisco Iborra, having co-1st-authored a paper in the journal Genome Research where it was found that modulation of cell metabolism can impact in alternative splicing. Again confirming that cell metabolism and mitochondria are important players in the control of cell fate and disease. In terms of cell fate, it was also shown that the cellular mitochondrial content determines the apoptotic fate and modulates the time to death, cells with higher mitochondrial content are more prone to die (Nat. Commun. 2018). Recently RN´s Lab has shown that the biochemical and physical modulation of chromatin structure can constitute a powerful tool to change transcription and gene expression. In one study it was shown that by using a simple biochemistry cue, the extracellular osmotic pressure, it was possible to change chromatin structure and transcription. Hyposmotic modulation promotes chromatin loosening and induces changes in RNA polymerase II (Pol II) activity. This constitutes an alternative route to manipulate cell fate decisions. This technology was tested in model protocols of induced pluripotency and transdifferentiation in cells growing in suspension and adherent to substrates, CD34+ umbilical-cord-blood (UCB), fibroblasts and B-cells. The efficiency and kinetics of these cell fate modulation processes were improved by transient hyposmotic modulation of the cell environment (Sci. Rep. 2018). In another study cells grown on low-rigidity substrates showed decreased focal adhesions maturation, stress fibres content and nuclear stretching. This physical modulation increased open chromatin nuclear regions and enhanced expression of endogenous pluripotency-related genes facilitating the induction of pluripotency (Sci. Rep. 2019). After returning to Portugal in 2010, RN became an expert in the synthesis and delivery of nanoparticles (NPs) with different cargos in primary and stem cells. He has patented a light-activated NP able to release retinoic acid inside the Leukemic niche and induce the differentiation of leukemia stem cells (Nat. Commun. 2017). He has been very fruitful in exploring new synthetic and natural (exosome) NPs to modulate cell fate in the context of angiogenesis and survival of transplanted cells. RN has supervised 3 PhDs and is currently supervising 2 PhD students. RN co-founded the company Exogenous Therapeutics that is developing exosome-based therapeutic products for regenerative medicine. RN is the Scientific Advisor of this company, that has attracted private funding ~800K€ and was the winner of the Everis Foundation Award 2016 and H2020 SME instrument Phase1. RN´s Lab aims to bridge basic science and technology transfer. RN is also a musician and has been involved in science outreach with Ciência Viva. He is composing a "Cellular-Opera" show.
Identificação

Identificação pessoal

Nome completo
Ricardo Neves Pires das Neves

Nomes de citação

  • Neves, Ricardo
  • Ricardo Pires das Neves
  • Ricardo das Neves

Identificadores de autor

Ciência ID
3B1D-52BC-7AE4
ORCID iD
0000-0003-2291-6610
Google Scholar ID
https://scholar.google.pt/citations?user=QciBVB4AAAAJ&hl=en

Endereços de correio eletrónico

  • ricardo.neves@uc-biotech.pt (Profissional)

Telefones

Telefone
  • 231249170 Ext.: 735 (Profissional)

Moradas

  • UC Biotech Parque Tecnológico de Cantanhede, Núcleo 04, Lote 8, 3060-197, Cantanhede, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Medicina Básica - Toxicologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Italiano Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2018
Concluído
FAMELAB 2018 (Outros)
Ciência Viva, Portugal

British Council Portugal, Portugal
2015
Concluído
COHITEC, Portugal (Outros)
Universidade do Porto Porto Business School, Portugal
2010/02/28
Concluído
Post-doctoral Career Development Award - Medical Research Council, UK (Pós-doutoramento)
MRC Molecular Haematology Unit, Reino Unido

Weatherall Institute of Molecular Medicine, Reino Unido
n.a.
2009/11/28
Concluído
Clinical Laboratory Sciences (Doctor of Philosophy)
University of Oxford, Reino Unido

Weatherall Institute of Molecular Medicine, Reino Unido
"The origin of extrinsic noise in gene expression" (TESE/DISSERTAÇÃO)
n.a.
2007
Concluído
Accreditation Scheme to conduct animal experimentation protocols under the Animals (Scientific Procedures) Act, 1986 (Postgraduate Certificate)
University of Oxford, Reino Unido
n.a.
2003
Concluído
Toxicologia (Mestrado)
Universidade de Aveiro, Portugal
"avaliação in vivo dos efeitos moduladores de antioxidantes na expressão da toxicidade do arsenito de sódio" (TESE/DISSERTAÇÃO)
aprovado por unanimidade (1st year: 18 out of 20)
1998
Concluído
Biologia (Licenciatura)
Universidade de Aveiro, Portugal
"n/a" (TESE/DISSERTAÇÃO)
14 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2013/04/01 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/03/01 - 2013/03/01 Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
(...)
2009/03/01 - 2010/02/01 Investigador Contratado (Investigação) Medical Research Council Molecular Haematology Unit, Reino Unido
Projetos

Bolsa

Designação Financiadores
2015/09/01 - Atual Impact of astrocyte-derived microvesicles for motor neuron degeneration and as vehicles to deliver neuroprotective cargoes in amyotrophic lateral sclerosis (ALS)
Project ELA-2015-002
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Santa Casa da Misericórdia de Lisboa
Concluído
2023/03 - 2024/02 Nanomedicina e células troianas para intervenção no licho leucémico
Provided by PTCRIS: 2022.05946.PTDC
Fundação para a Ciência e a Tecnologia
2020/10/02 - 2021/10/01 EXOLUNG: Umbilical Cord Blood derived exosomes for treatment of COVID-19 related Acute Respiratory Distress Syndrome (ARDS)
CENTRO-01-02B7-FEDER-070018
Scientific Consultant
Concluído
2019/12/30 - 2020/12/31 Tailoring EXosomes for Autoimmune Diseases
H2020–INNOSUP–2019–02
Scientific Consultant
2016/09/01 - 2019/08/31 Exo-Wound aims to strengthen research, technological development and innovation for the treatment of chronic wounds
CENTRO-01-0247-FEDER-022398
Scientific Consultant
2012/05/01 - 2015/09/30 Modulation of hematopoietic stem cell (HSC) activity by transcription factor-releasing nanoparticles- STEMCELLMODULATORS
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/05 - 2015/09 Modulação da actividade de células estaminais hematopoiéticas por acção de nanopartículas capazes de libertar factores de transcrição - STEMCELLMODULATORS
Provided by PTCRIS: PTDC/CTM-NAN/120552/2010
Fundação para a Ciência e a Tecnologia
2011/04/01 - 2014/12/31 Generation of cord blood-derived Induced Pluripotent Stem cells using a non-viral approach and their differentiation into cardiomyocytes- iPSCardio
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/04 - 2014/12 Indução de células estaminais pluripotentes a partir de células do sangue do cordão umbilical através de metodologia não-viral e a sua diferenciação em cardiomiócitos - iPSCardio
Provided by PTCRIS: PTDC/SAU-ENB/113696/2009
Fundação para a Ciência e a Tecnologia
2005/03 - 2009/02 MODULATION OF THE TOXICITY OF ARSENIC AND CHROMIUM COMPOUNDS BY DIETARY FACTORS AND SYNTHETIC ANTIOXIDANT COMPOUNDS
Provided by PTCRIS: SFRH/BD/18218/2004
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Emanuel Quartin; Susana Rosa; Sara Gonzalez-Anton; Laura Mosteo Lopez; Vitor Francisco; Delfim Duarte; Cristina Lo Celso; Ricardo Pires das Neves; Lino Ferreira. "Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche". Bioactive Materials (2024): https://doi.org/10.1016/j.bioactmat.2023.12.017.
    10.1016/j.bioactmat.2023.12.017
  2. Tânia Barata; Vítor Pereira; Ricardo Pires das Neves; Miguel Rocha. "Reconstruction of cell-specific models capturing the influence of metabolism on DNA methylation in cancer". Computers in Biology and Medicine (2024): https://doi.org/10.1016/j.compbiomed.2024.108052.
    10.1016/j.compbiomed.2024.108052
  3. Ricardo Pires das Neves; Mónica Chagoyen; Antonio Martinez-Lorente; Carlos Iñiguez; Ana Calatrava; Juana Calabuig; Francisco J. Iborra. "Each Cellular Compartment Has a Characteristic Protein Reactive Cysteine Ratio Determining Its Sensitivity to Oxidation". Antioxidants (2023): https://doi.org/10.3390/antiox12061274.
    10.3390/antiox12061274
  4. Barata, Tânia; Vieira, Vítor; Rodrigues, Rúben; Neves, Ricardo Pires das; Rocha, Miguel. "Reconstruction of tissue-specific genome-scale metabolic models for human cancer stem cells". Computers in Biology and Medicine 142 (2022): 105177. http://dx.doi.org/10.1016/j.compbiomed.2021.105177.
    10.1016/j.compbiomed.2021.105177
  5. Almeida-Lousada, Hélder; Mestre, André; Ramalhete, Sara; Price, Aryeh J.; de Mello, Ramon Andrade; Marreiros, Ana D.; Neves, Ricardo Pires das; Castelo-Branco, Pedro. "Screening for Colorectal Cancer Leading into a New Decade: The “Roaring ‘20s” for Epigenetic Biomarkers?". Current Oncology 28 6 (2021): 4874-4893. http://dx.doi.org/10.3390/curroncol28060411.
    10.3390/curroncol28060411
  6. Fonseca, André; Ramalhete, Sara Ventura; Mestre, André; Pires das Neves, Ricardo; Marreiros, Ana; Castelo-Branco, Pedro; Roberto, Vânia Palma. "Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression". Aging 13 18 (2021): 21991-22029. http://dx.doi.org/10.18632/aging.203556.
    10.18632/aging.203556
  7. Sílvia C. Rodrigues; Renato M. S. Cardoso; Patricia C. Freire; Cláudia F. Gomes; Filipe V. Duarte; Ricardo Pires das Neves; Joana Simões-Correia. "Immunomodulatory Properties of Umbilical Cord Blood-Derived Small Extracellular Vesicles and Their Therapeutic Potential for Inflammatory Skin Disorders". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22189797.
    10.3390/ijms22189797
  8. Rodrigues, Silvia C.; Cardoso, Renato M. S.; Gomes, Claudia F.; Duarte, Filipe V.; Freire, Patricia C.; Neves, Ricardo; Simoes-Correia, Joana. "Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles". Membranes 11 9 (2021): 647. http://dx.doi.org/10.3390/membranes11090647.
    10.3390/membranes11090647
  9. Renato M. S. Cardoso; Silvia C. Rodrigues; Claudia F. Gomes; Filipe V. Duarte; Maryse Romao; Ermelindo C. Leal; Patricia C. Freire; Ricardo Neves; Joana Simões-Correia. "Development of an optimized and scalable method for isolation of umbilical cord blood-derived small extracellular vesicles for future clinical use". STEM CELLS Translational Medicine (2021): https://doi.org/10.1002/sctm.20-0376.
    10.1002/sctm.20-0376
  10. Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho. "Correction to: In vitro mechanistic studies on a-amanitin and its putative antidotes". Archives of Toxicology (2020): https://doi.org/10.1007/s00204-020-02735-0.
    10.1007/s00204-020-02735-0
  11. Daniela Ferreira Rodrigues; Ricardo Pires das Neves; Alexandra T. P. Carvalho; Maria Lourdes Bastos; Vera M. Costa; Félix Carvalho. "In vitro mechanistic studies on a-amanitin and its putative antidotes". Archives of Toxicology (2020): https://doi.org/10.1007/s00204-020-02718-1.
    10.1007/s00204-020-02718-1
  12. Neves, Ricardo. "Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction". Scientific Reports (2019): http://dx.doi.org/10.1038/s41598-019-45352-3.
    10.1038/s41598-019-45352-3
  13. Neves, Ricardo. "Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation". Scientific Reports (2018): http://dx.doi.org/10.1038/s41598-018-25517-2.
    10.1038/s41598-018-25517-2
  14. Neves, Ricardo. "Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation". Frontiers in Cell and Developmental Biology (2018): http://dx.doi.org/10.3389/fcell.2018.00103.
    10.3389/fcell.2018.00103
  15. Márquez-Jurado, S.; Díaz-Colunga, J.; Das Neves, R.P.; Martinez-Lorente, A.; Almazán, F.; Guantes, R.; Iborra, F.J.. "Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression". Nature Communications 9 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041107950&partnerID=MN8TOARS.
    10.1038/s41467-017-02787-4
  16. Boto, C.; Quartin, E.; Cai, Y.; Martín-Lorenzo, A.; Cenador, M.B.G.; Pinto, S.; Gupta, R.; et al. "Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation". Nature Communications 8 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85026559803&partnerID=MN8TOARS.
    10.1038/ncomms15204
  17. Gouveia, P.J.; Rosa, S.; Ricotti, L.; Abecasis, B.; Almeida, H.V.; Monteiro, L.; Nunes, J.; et al. "Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes". Biomaterials 139 (2017): 213-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020728965&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2017.05.048
  18. Guantes, R.; Rastrojo, A.; Neves, R.; Lima, A.; Aguado, B.; Iborra, F.J.. "Global variability in gene expression and alternative splicing is modulated by mitochondrial content". Genome Research 125 5 (2015): 633-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929660832&partnerID=MN8TOARS.
    10.1101/gr.178426.114
  19. Ricotti, L.; Das Neves, R.P.; Ciofani, G.; Canale, C.; Nitti, S.; Mattoli, V.; Mazzolai, B.; Ferreira, L.; Menciassi, A.. "Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblasts". Journal of Nanoparticle Research 16 2 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84894539117&partnerID=MN8TOARS.
    10.1007/s11051-014-2247-z
  20. Gomes, R.S.M.; Neves, R.P.D.; Cochlin, L.; Lima, A.; Carvalho, R.; Korpisalo, P.; Dragneva, G.; et al. "Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial". ACS Nano 7 4 (2013): 3362-3372. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876588539&partnerID=MN8TOARS.
    10.1021/nn400171w
  21. Johnston, I.G.; Gaal, B.; das Neves, R.P.; Enver, T.; Iborra, F.J.; Jones, N.S.. "Mitochondrial variability as a source of extrinsic cellular noise". PLoS Computational Biology 8 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84861161954&partnerID=MN8TOARS.
    10.1371/journal.pcbi.1002416
  22. Valente, A.X.C.N.; das Neves, R.P.; Oliveira, P.J.. "Epigenetic engineering to reverse the Parkinson's expression state". Parkinsonism and Related Disorders 18 6 (2012): 717-721. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862191970&partnerID=MN8TOARS.
    10.1016/j.parkreldis.2012.04.018
  23. Paulo, C.S.O.; Pires Das Neves, R.; Ferreira, L.S.. "Nanoparticles for intracellular-targeted drug delivery". Nanotechnology 22 49 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-81855212480&partnerID=MN8TOARS.
    10.1088/0957-4484/22/49/494002
  24. Vazão, H.; das Neves, R.P.; Grãos, M.; Ferreira, L.. "Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells". PLoS ONE 6 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952523704&partnerID=MN8TOARS.
    10.1371/journal.pone.0017771
  25. Dalziel, M.; Kolesnichenko, M.; Das Neves, R.P.; Iborra, F.; Goding, C.; Furger, A.. "a-MSH regulates intergenic splicing of MC1R and TUBB3 in human melanocytes". Nucleic Acids Research 39 6 (2011): 2378-2392. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953710861&partnerID=MN8TOARS.
    10.1093/nar/gkq1125
  26. das Neves, R.P.; Jones, N.S.; Andreu, L.; Gupta, R.; Enver, T.; Iborra, F.J.. "Connecting variability in global transcription rate to mitochondrial variability". PLoS Biology 8 12 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78650442826&partnerID=MN8TOARS.
    10.1371/journal.pbio.1000560
  27. Favaro, E.; Ramachandran, A.; McCormick, R.; Gee, H.; Blancher, C.; Crosby, M.; Devlin, C.; et al. "MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU". PLoS ONE 5 4 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956402239&partnerID=MN8TOARS.
    10.1371/journal.pone.0010345
  28. Brown, J.M.; Green, J.; Das Neves, R.P.; Neves, R.P.D.; Wallace, H.A.C.; Smith, A.J.H.; Hughes, J.; et al. "Association between active genes occurs at nuclear speckles and is modulated by chromatin environment". Chemtracts 21 10 (2008): 411-413. http://www.scopus.com/inward/record.url?eid=2-s2.0-66849113444&partnerID=MN8TOARS.
    10.1083/jcb.200803174
  29. Carvalho, F.; Soares, M.E.; Fernandes, E.; Remião, F.; Carvalho, M.; Duarte, J.A.; Pires-das-Neves, R.; Pereira, M.D.L.; Bastos, M.D.L.. "Repeated administration of d-amphetamine results in a time-dependent and dose-independent sustained increase in urinary excretion of p-hydroxyamphetamine in mice". Journal of Health Science 53 4 (2007): 371-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547566233&partnerID=MN8TOARS.
    10.1248/jhs.53.371
  30. Pereira, M.D.L.; Das Neves, R.P.; Oliveira, H.; Santos, T.M.; De Jesus, J.P.. "Effect of Cr(V) on reproductive organ morphology and sperm parameters: An experimental study in mice". Environmental Health: A Global Access Science Source 4 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-23944463762&partnerID=MN8TOARS.
    10.1186/1476-069X-4-9
  31. Valentão, P.; Carvalho, M.; Carvalho, F.; Fernandes, E.; Neves, R.P.D.; Pereira, M.L.; Andrade, P.B.; Seabra, R.M.; Bastos, M.L.. "Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo". Journal of Ethnopharmacology 94 2-3 (2004): 345-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344716319&partnerID=MN8TOARS.
    10.1016/j.jep.2004.06.012
  32. Pires Das Neves, R.N.; Carvalho, F.; Carvalho, M.; Fernandes, E.; Soares, E.; Bastos, M.D.L.; Pereira, M.D.L.. "Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice". Toxicologic Pathology 32 5 (2004): 527-535. http://www.scopus.com/inward/record.url?eid=2-s2.0-4544289287&partnerID=MN8TOARS.
    10.1080/01926230490502566
  33. Pires Das Neves, R.; Santos, T.M.; De Lourdes Pereira, M.; Pedrosa De Jesus, J.. "Comparative histological studies on liver of mice exposed to Cr(VI) and Cr(V) compounds". Human and Experimental Toxicology 21 7 (2002): 365-369. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036656032&partnerID=MN8TOARS.
    10.1191/0960327102ht243oa
  34. Pereira, M.L.; Santos, T.M.; Pires das Neves, R.; Costa, F.G.; Pedrosa de Jesus, J.. "Cr(V) involvement in the toxicity pathway of testicular damage". Asian Journal of Andrology 4 2 (2002): 153-155. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035987253&partnerID=MN8TOARS.
  35. Carvalho, M.; Carvalho, F.; Remião, F.; De Lourdes Pereira, M.; Pires-Das-Neves, R.; De Lourdes Bastos, M.. "Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: Influence of ambient temperature". Archives of Toxicology 76 3 (2002): 166-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036214775&partnerID=MN8TOARS.
    10.1007/s00204-002-0324-z
  36. Das Neves, R.P.; Santos, T.M.; Pereira, M.D.L.; De Jesus, J.P.. "Chromium(VI) induced alterations in mouse spleen cells: A short-term assay". Cytobios 413 1 SUPPL. (2001): 27-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348238820&partnerID=MN8TOARS.
Poster em conferência
  1. Domingues, Catarina; Margarida Geraldo; André Matos; Cláudio Almeida; Sandra I. Anjo; Bruno Manadas; Ricardo Pires das Neves; Mário Grãos. "Identification and characterization of Cofilin-1 as a new mechanotransduction player for the sensing of extracellular stiffness". Trabalho apresentado em CIBB metting 2019, 2019.
  2. Domingues, Catarina; Margarida Geraldo; André Matos; Cláudio Almeida; Sandra I. Anjo; Bruno Mandas; Ricardo Pires das Neves; Mário Grãos. "Identification and characterization of Cofilin-1 in the proteome of Mesenchymal Stem Cells". Trabalho apresentado em BEBday2019 for the 3rd BEB/Bluepharma award, 2019.
Resumo em conferência
  1. Ricardo Pires das Neves; Quartin, Emanuel; González Antón, Sara; Rosa, Susana; Francisco, Vitor; Mosteo, Laura; Duarte, Delfim; Lo Celso, Cristina ; Ferreira, Lino. "Cells as therapeutical vehicles for the delivery of light sensitive retinoic acid nanoparticles for leukemic niche modulation". Trabalho apresentado em EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2021.
    Publicado
Tese / Dissertação
  1. Neves, Ricardo. "The origin of global extrinsic noise in gene expression". Doutoramento, University of Oxford, 2009. https://solo-aleph-prd.bodleian.ox.ac.uk/?func=direct&local_base=BIB01&doc_number=020317848&format=999.
  2. Neves, Ricardo Neves Pires das. "Avaliação in vivo dos efeitos moduladores de antioxidantes na expressão da toxicidade do arsenito de sódio". Mestrado, 2003. http://hdl.handle.net/10773/18934.

Propriedade Intelectual

Patente
  1. Neves, Ricardo; Lino Ferreira; Carlos Boto. 2015. "LIGHTACTIVATABLE POLYMERIC NANOPARTICLES".
    Concedida/Emitida
  2. Neves, Ricardo; Lino Ferreira; Renata Gomes. 2014. "Nanoparticles and Uses Thereof".
    Concedida/Emitida

Outros

Empresa spin-off
  1. 2015. Exogenus Therapeutics. R&D Cell Therapy and Regenerative Medicine Products. https://www.exogenus-t.com/.
Outra produção
  1. Towards the Maturation and Characterization of Smooth Muscle Cells Derived from Human Embryonic Stem Cells. In this study we demonstrate that CD34+ cells derived from human embryonic stem cells (hESCs) have higher smooth muscle cell (SMC) potential than CD34- cells. We report that from all inductive signals tested, retinoic acid (RA) and platelet derived growth factor (PDGFBB) are the most effective agents in guiding the differentiation of CD34+ cells into smooth muscle progenitor cells (SMPCs) characte. 2011. Vazão, Helena; Neves, Ricardo Pires das; Grãos, Mário; Ferreira, Lino. http://hdl.handle.net/10316/15680.
  2. Repeated administration of d-amphetamine results in a time-dependent and dose-independent sustained increase in urinary excretion of p-hydroxyamphetamine in mice. The biotransformation of d-amphetamine into p-hydroxyamphetamine (HA) by cytochrome P450 occurs in several species besides humans. The extent of HA excretion varies among species and the oxidative pathway involved in this biotransformation is reported to be implicated in the toxic effects of d-amphetamine. The aim of this study was to evaluate the influence of dose and repeated administration of d. 2007. Faculdade de Farmácia; Faculdade de Desporto. 1344-9702.
    10.1248/jhs.53.371
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2019/01/05 - Atual Metabolic modelling of cancer stem cells
Orientador
BEB PhD program (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/05/11 - Atual Epigenetic biomarker development and big data analysis in Colorectal Cancer
Coorientador
Universidade do Algarve - Campus de Gambelas, Portugal
2013/01/01 - 2018/06/01 Modulation of haematopoietic stem cell activity by transcription factor-releasing nanoparticles
Orientador
MIT-Portugal PhD-program on Bioengineering (Doutoramento)
Universidade Nova de Lisboa, Portugal
2012/01/01 - 2017/05/02 Biophysical modulation of cell fate through chromatin remodelling
Orientador
MIT-Portugal PhD-program on Bioengineering (Doutoramento)
Universidade Nova de Lisboa, Portugal
2012/01/01 - 2016/06/05 Cardiac tissue constructs for drug screening
Orientador
BEB PhD program (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2014/01/01 - 2014/06/06 Tissue Engineering
Orientador
Chemical engineering and biochemistry (Licenciatura/Bacharelato)
Universidade Nova de Lisboa, Portugal
2013/01/01 - 2014/04/03 Modulation of induced pluripotency by substrate rigidity
Coorientador
Molecular and Cell Biology (Mestrado)
Universidade de Coimbra, Portugal
2011/01/01 - 2012/06/05 Reprogramming strategies for cord-blood cd34+ cells based on mitochondrial phenotype
Orientador
Biomedical Engineering (Mestrado)
Universidade de Coimbra, Portugal
2010/01/01 - 2011/06/05 Generation of a reporter system for monitorization of endothelial differentiation
Orientador
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2024/01/23 “From Umbilical Cord Blood Hematopoietic Stem/Progenitor Cells to T Cells: a Scalable and Bioengineering Approach of the Thymic Microenvironment”.
Arguente principal
Sara Ventura Bucar (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/02/21 Extracellular Vesicles as Platforms for Therapeutic microRNA delivery
Arguente principal
Abreu, Ricardo Cerqueira de (Doutoramento)
Universidade de Coimbra, Portugal
2020/12/04 Impact of human iPSC-derived NESC transplantation in MJD-associated neuropathology and motor impairments.
Arguente principal
Vinhas, Ana Catarina Paulino do Ó (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/05/15 Dissecting the potential mechanisms and roles of notch receptors-ligands interactions in human HSC expansion
Arguente
Joana Isabel Gonçalves Carmelo (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/10/29 TERT HYPERMETHYLATED ONCOLOGIC REGION (THOR) AS A BIOMARKER FOR BREAST CANCER
Arguente principal
Joana Apolónio (Doutoramento)
Universidade do Algarve, Portugal
2019/10/07 Therapeutic Effect of Novel Dressing Coated LL37-AuNP For The Enhanced Wound Healing
Arguente principal
Denise Irene Marta Monteiro (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09/19 Towards novel stem cell and protein based therapies for myocardium regeneration
Arguente
Maria João Sebastião (Doutoramento)
Universidade Nova de Lisboa, Portugal
2017/08/01 Designing transcription factors for efficient hematopoietic reprogramming
Arguente principal
Rita Alexandra Silvério Alves (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07/01 MicroRNA-124-loaded nanoparticles as a new promising therapeutic tool for neural stem cell-based brain repair strategies
Arguente principal
Cláudia Marisa Monteiro Saraiva (Doutoramento)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/06/06 Master in Biochemistry – Thesis title: Designing transcription factors for efficient hematopoietic reprogramming, University of Coimbra
Arguente principal
Rita Alexandre Silvério Alves (Mestrado)
Universidade de Coimbra, Portugal
2017/05/05 PhD in Bioengineering MIT-Portugal program – Thesis title: MicroRNA-124-loaded nanoparticles as a new promising therapeutic tool for neural stem cell-based brain repair strategies
Arguente principal
Cláudia Marisa Monteiro Saraiva (Doutoramento)
Universidade Nova de Lisboa, Portugal
2015/06/06 Low doses of ionizing radiation induce angiogenesis after radiotherapy
Arguente principal
Telmo Alexandre Santos Freitas (Mestrado)
Universidade de Coimbra, Portugal
2013/06/06 Characterization of human umbilical cord matrix mesenchymal stem cells isolated and cultured on tunable hydrogel-based platforms
Arguente principal
Plácido Júnio da Paixão Pereira (Mestrado)
Universidade de Coimbra, Portugal

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2015/06/01 - Atual Scientific Consultant of the Company Exogenus Therapeutics Exogenus Therapeutics, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019/04/03 - Atual Lecturer in Translational Biology and Biomedicine (3rd year - optional) of the courses of Biology and Biochemistry, University of Coimbra (Bacharelato) Universidade de Coimbra, Portugal
2018/10/02 - Atual Lecturer in Regenerative Medicine (5th year) of the integrated master course on Biomdeical Engineering (MIEBIOM), University of Coimbra (Mestrado integrado) Universidade de Coimbra, Portugal
2015/02/04 - Atual Invited Lecturer, Faculty of Medicine University of Coimbra, Doctoral Program advanced course on Cell Regulation. (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Faculdade de Medicina, Portugal
2014/03/10 - Atual Invited Lecturer ICVS University of Minho, Post-Graduation Course “Stem Cells Get Practical”. (Especialização pós-bacharelato) Universidade do Minho, Portugal
2012/02/15 - Atual PDBEB Advanced Course "Cell and Tissue Engineering" (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/11/17 - 2015/01/01 MIT-Portugal Bioengineering PhD program (Curso de doutoramento (conclusão de unidades curriculares)) MIT-Portugal Program, Portugal
2014/10/23 - 2014/10/25 Curso Teórico-Práctico sobre Células Troncales y Embriología Clínica (Postgraduate Certificate) Universitat d'Alacant, Espanha

Membro de associação

Nome da associação Tipo de participação
2012/01/01 - Atual Portuguese Society for Stem Cells and Cell Therapy

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2023/12/04 - 2023/12/20 Prémio Investigador Universidade do Algarve (segunda edição). Convite para integrar o comité de Júri deste Prémio que é atribuído e limitado aos investigadores e professores da UAlg e visa distinguir e trazer visibilidade à investigação da UAlg, sendo dirigido a todas as áreas do saber que funcionam na Universidade.
Membro
Universidade do Algarve, Portugal
2013/06/01 - 2015/06/01 Member of the board of directors of "Portuguese Society for Stem Cells and Cell Therapy"
Coordenador
Portuguese Society for Stem Cells and Cell Therapy, Portugal
Distinções

Prémio

2018 FAMELAB Finalist
Ciência Viva, Portugal

British Council Portugal, Portugal
2016 EVERIS
Everis, Espanha
2015 ANJE Best Entrepreneur of the Year
ANJE Associação Nacional de Jovens Empresários, Portugal
2011 The Mending Broken Hearts award - Science Image Competition
British Heart Foundation, Reino Unido

Outra distinção

2009 Career Development Award – Post-doctoral Fellowship
MRC Molecular Haematology Unit, Reino Unido
2008 2nd prize for Best Talk; WIMM Student’s Day, University of Oxford,
University of Oxford, Reino Unido
2005 PhD Scholarship
Fundação para a Ciência e a Tecnologia, Portugal
2004 PhD Scholarship
Universidade de Aveiro Departamento de Biologia, Portugal
2001 Master Scholarship Biology department, University of Aveiro
Universidade de Aveiro, Portugal
1999 BIC Scholarship
Fundação para a Ciência e a Tecnologia, Portugal