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Identificação

Identificação pessoal

Nome completo
JOÃO CARLOS SOUSA

Nomes de citação

  • SOUSA, JOÃO CARLOS

Identificadores de autor

Ciência ID
341F-72E5-EAC0
ORCID iD
0000-0003-3249-0035
Google Scholar ID
https://scholar.google.com/citations?user=rtFfCZ8AAAAJ&hl=pt-PT
Scopus Author Id
55989548500
Formação
Grau Classificação
2005/06/30
Concluído
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2005
Concluído
 Ciências Biomédicas (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Searching for An Essencial Function for Transthyretin in the Central Nervous System" (TESE/DISSERTAÇÃO)
1999/07
Concluído
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2005 - Atual Investigador (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2015 - Atual Professor Associado (Docente Universitário) Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Escola de Medicina, Portugal
2013 - 2015 Professor Auxiliar (Docente Universitário) Universidade do Minho Escola de Medicina, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2015 - 2017 Conselho científico/técnico-científico ou orgão correspondente Universidade do Minho Escola de Medicina, Portugal
2013 - 2014 Conselho científico/técnico-científico ou orgão correspondente Universidade do Minho Escola de Medicina, Portugal
Projetos

Projeto

Designação Financiadores
2009/04/01 - 2013/03/30 New approaches in multiple sclerosis diagnosis: the role of the choroid plexus.
PIC/IC/83231/2007
Investigador
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/05/02 - 2012/05/01 Neudesina - estudo da função de um novo factor neurotrófico
PTDC/SAU-OSM/104475/2008
Investigador responsável
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/08/01 - 2008/07/31 The role of choroid plexus proteins in brain inflammation
POCI/SAU-NEU/56618/2004
Investigador
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Sofia Pereira das Neves; João Carlos Sousa; Ricardo Magalhães; Fuying Gao; Giovanni Coppola; Sebatien Mériaux; Fawzi Boumezbeur; et al. "Astrocytes Undergo Metabolic Reprogramming in the Multiple Sclerosis Animal Model". Cells (2023): https://doi.org/10.3390/cells12202484.
    10.3390/cells12202484
  2. Andreia Teixeira-Castro; João Carlos Sousa; Cármen Vieira; Joana Pereira-Sousa; Daniela Vilasboas-Campos; Fernanda Marques; Perpétua Pinto-do-Ó; Patrícia Maciel. "Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model". Biomedicines (2023): https://doi.org/10.3390/biomedicines11061731.
    10.3390/biomedicines11061731
  3. Ana Catarina Ferreira; Nuno Sousa; João Carlos Sousa; Fernanda Marques. "Age-related changes in mice behavior and the contribution of lipocalin-2". Frontiers in Aging Neuroscience 15 (2023): http://dx.doi.org/10.3389/fnagi.2023.1179302.
    10.3389/fnagi.2023.1179302
  4. Sofia P. das Neves; Cláudia Serre-Miranda; João C. Sousa; Patrício S. Costa; Nuno Sousa; João J. Cerqueira; Fernanda Marques. "Lipocalin-2 does not influence EAE clinical score but it increases inflammation in central nervous system". Journal of Neuroimmunology 368 (2022): 577872-577872. http://dx.doi.org/10.1016/j.jneuroim.2022.577872.
    10.1016/j.jneuroim.2022.577872
  5. Saba Abdulghani; Ângela Afonso; Mireia Castillo-Martin; Javier Martín-Fernández; Inês Franco; Parreira B.; Ana Rita Couto; et al. "The Role of Biobanks in the Fight against COVID-19 Pandemic: The Portuguese Response". Acta Médica Portuguesa 35 6 (2022): 411-415. http://dx.doi.org/10.20344/amp.17856.
    10.20344/amp.17856
  6. Miguel A. Santos-Silva; Nuno Sousa; João Carlos Sousa. "Correlation Analysis between Hemoglobin and C-Reactive Protein in Patients Admitted to an Emergency Unit". Journal of Clinical Medicine 10 22 (2021): 5411-5411. https://doi.org/10.3390/jcm10225411.
    10.3390/jcm10225411
  7. Eduarda Carvalho-Correia; Carla Calçada; Fernando Branca; Nuria Estévez-Gómez; Loretta De Chiara; Nair Varela; Pilar Gallego-García; et al. "OmniSARS2: A Highly Sensitive and Specific RT-qPCR-Based COVID-19 Diagnostic Method Designed to Withstand SARS-CoV-2 Lineage Evolution". Biomedicines (2021): https://doi.org/10.3390/biomedicines9101314.
    10.3390/biomedicines9101314
  8. SOUSA, JOÃO. "Performance assessment of 11 commercial serological tests for SARS-CoV-2 on hospitalised COVID-19 patients.". International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (2021): https://europepmc.org/articles/PMC7817432.
    10.1016/j.ijid.2021.01.038
  9. SOUSA, JOÃO. "Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal.". Emerging microbes & infections (2020): https://europepmc.org/articles/PMC7717510.
    10.1080/22221751.2020.1844552
  10. SOUSA, JOÃO. "Altered astrocytic function in experimental neuroinflammation and multiple sclerosis.". Glia (2020): https://doi.org/10.1002/glia.23940.
    10.1002/glia.23940
  11. Diana Soares da Costa; João C. Sousa; Sandro Dá Mesquita; Nevena I. Petkova-Yankova; Fernanda Marques; Rui L. Reis; Nuno Sousa; Iva Pashkuleva. "Bioorthogonal Labeling Reveals Different Expression of Glycans in Mouse Hippocampal Neuron Cultures during Their Development". Molecules 25 4 (2020): 795-795. https://doi.org/10.3390/molecules25040795.
    10.3390/molecules25040795
  12. SOUSA, JOÃO. "The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization.". Nature communications (2019): https://europepmc.org/articles/PMC6911097.
    10.1038/s41467-019-13575-7
  13. Ferreira, A.C.; Novais, A.; Sousa, N.; Sousa, J.C.; Marques, F.. "Voluntary running rescues the defective hippocampal neurogenesis and behaviour observed in lipocalin 2-null mice". Scientific Reports 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85061251008&partnerID=MN8TOARS.
    10.1038/s41598-018-38140-y
  14. Mota, C.; Taipa, R.; das Neves, S.P.; Monteiro-Martins, S.; Monteiro, S.; Palha, J.A.; Sousa, N.; Sousa, J.C.; Cerqueira, J.J.. "Structural and molecular correlates of cognitive aging in the rat". Scientific Reports 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85061573471&partnerID=MN8TOARS.
    10.1038/s41598-019-39645-w
  15. Magalhães, R.; Novais, A.; Barrie`re, D.A.; Marques, P.; Marques, F.; Sousa, J.C.; Cerqueira, J.J.; et al. "A resting-state functional MR imaging and spectroscopy study of the dorsal hippocampus in the chronic unpredictable stress rat model". Journal of Neuroscience 39 19 (2019): 3640-3650. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065818591&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.2192-18.2019
  16. Ferreira, A.C.; Sousa, N.; Bessa, J.M.; Sousa, J.C.; Marques, F.. "Metabolism and adult neurogenesis: Towards an understanding of the role of lipocalin-2 and iron-related oxidative stress". Neuroscience and Biobehavioral Reviews 95 (2018): 73-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054364759&partnerID=MN8TOARS.
    10.1016/j.neubiorev.2018.09.014
  17. Magalhães, R.; Barrière, D.A.; Novais, A.; Marques, F.; Marques, P.; Cerqueira, J.; Sousa, J.C.; et al. "The dynamics of stress: a longitudinal MRI study of rat brain structure and connectome". Molecular Psychiatry 23 10 (2018): 1998-2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051127999&partnerID=MN8TOARS.
    10.1038/mp.2017.244
  18. Novais, A.; Silva, A.; Ferreira, A.C.; Falcão, A.M.; Sousa, N.; Palha, J.A.; Marques, F.; Sousa, J.C.. "Adult hippocampal neurogenesis modulation by the membrane-associated progesterone receptor family member neudesin". Frontiers in Cellular Neuroscience 12 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85058943033&partnerID=MN8TOARS.
    10.3389/fncel.2018.00463
  19. Marques, F.; Sousa, J.C.; Brito, M.A.; Pahnke, J.; Santos, C.; Correia-Neves, M.; Palha, J.A.. "The choroid plexus in health and in disease: dialogues into and out of the brain". Neurobiology of Disease 107 (2017): 32-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995495545&partnerID=MN8TOARS.
    10.1016/j.nbd.2016.08.011
  20. Serrano, J.B.; Martins, F.; Sousa, J.C.; Pereira, C.D.; Van Pelt, A.M.M.; Rebelo, S.; Da Cruz E Silva, O.A.B.. "Descriptive analysis of lap1 distribution and that of associated proteins throughout spermatogenesis". Membranes 7 2 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018271703&partnerID=MN8TOARS.
    10.3390/membranes7020022
  21. Ferreira, A C; Santos, T; Sampaio-Marques, B; Novais, A; Mesquita, S D; Ludovico, P; Bernardino, L; et al. "Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours.". Molecular psychiatry (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:28485407&KeyUID=MEDLINE:28485407.
    10.1038/mp.2017.95
  22. Dá Mesquita, S.; Ferreira, A.C.; Sousa, J.C.; Correia-Neves, M.; Sousa, N.; Marques, F.. "Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system". Neuroscience and Biobehavioral Reviews 68 (2016): 547-562. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978997730&partnerID=MN8TOARS.
    10.1016/j.neubiorev.2016.06.014
  23. Pires, L.R.; Marques, F.; Sousa, J.C.; Cerqueira, J.; Pinto, I.M.. "Nano- and micro-based systems for immunotolerance induction in multiple sclerosis". Human Vaccines and Immunotherapeutics 12 7 (2016): 1886-1890. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963511160&partnerID=MN8TOARS.
    10.1080/21645515.2016.1138190
  24. Teixeira, F.G.; Vasconcelos, N.L.; Gomes, E.D.; Marques, F.; Sousa, J.C.; Sousa, N.; Silva, N.A.; et al. "Bioengineered cell culture systems of central nervous system injury and disease". Drug Discovery Today 21 9 (2016): 1456-1463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975780622&partnerID=MN8TOARS.
    10.1016/j.drudis.2016.04.020
  25. Salgado, Antonio J.; Sousa, Joao C.; Costa, Bruno M.; Pires, Ana O.; Mateus-Pinheiro, Antonio; Teixeira, F. G.; Pinto, Luisa; Sousa, Nuno. "Mesenchymal stem cells secretome as a modulator of the neurogenic niche: basic insights and therapeutic opportunities". Frontiers in Cellular Neuroscience 9 (2015): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000357872600001&KeyUID=WOS:000357872600001.
    10.3389/fncel.2015.00249
  26. Marques, Simone M.; Santos, Adriano; Goncalves, Luis M.; Sousa, Joao C.; Bueno, Paulo R.. "Sensitive label-free electron chemical capacitive signal transduction for D-dimer electroanalysis". Electrochimica Acta 182 (2015): 946-952. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365075800117&KeyUID=WOS:000365075800117.
    10.1016/j.electacta.2015.09.169
  27. Neves, S.; Mesquita, S.; Ferreira, C.; Sousa, J.; Cerqueira, J.; Sousa, N.; Correia-Neves, M.; Palha, J.; Marques, F.. "Multiple Sclerosis: studying lipocalin 2 as a novel player in the pathophysiology of the disease". Glia 63 (2015): E373-E374. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000356386700629&KeyUID=WOS:000356386700629.
  28. Bockmühl, Y.; Patchev, A.V.; Madejska, A.; Hoffmann, A.; Sousa, J.C.; Sousa, N.; Holsboer, F.; Almeida, O.F.X.; Spengler, D.. "Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress". Epigenetics 10 3 (2015): 247-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925331860&partnerID=MN8TOARS.
    10.1080/15592294.2015.1017199
  29. Mesquita, S.D.; Ferreira, A.C.; Gao, F.; Coppola, G.; Geschwind, D.H.; Sousa, J.C.; Correia-Neves, M.; et al. "The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease". Brain, Behavior, and Immunity 49 (2015): 280-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940599385&partnerID=MN8TOARS.
    10.1016/j.bbi.2015.06.008
  30. Marques, F.; Sousa, J.C.. "The choroid plexus is modulated by various peripheral stimuli: Implications to diseases of the central nervous system". Frontiers in Cellular Neuroscience 9 APR (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84927586383&partnerID=MN8TOARS.
    10.3389/fncel.2015.00136
  31. Ferreira, A.C.; Dá Mesquita, S.; Sousa, J.C.; Correia-Neves, M.; Sousa, N.; Palha, J.A.; Marques, F.. "From the periphery to the brain: Lipocalin-2, a friend or foe?". Progress in Neurobiology 131 (2015): 120-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938060147&partnerID=MN8TOARS.
    10.1016/j.pneurobio.2015.06.005
  32. Goncalves, Luis M.; Moreira, Manuela M.; Azevedo, Carla F.; Valente, Ins M.; Sousa, Joao C.; Scanlan, Thomas S.; Compton, Richard G.; Rodrigues, Jose A.. "Proof of Concept of the Electrochemical Sensing of 3-Iodothyronamine ( T1AM) and Thyronamine ( T0AM)". Chemelectrochem 1 10 (2014): 1623-1626. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000343760900004&KeyUID=WOS:000343760900004.
    10.1002/celc.201402165
  33. Mesquita, S.D.; Ferreira, A.C.; Falcao, A.M.; Sousa, J.C.; Oliveira, T.G.; Correia-Neves, M.; Sousa, N.; Marques, F.; Palha, J.A.. "Lipocalin 2 modulates the cellular response to amyloid beta". Cell death and differentiation 21 10 (2014): 1588-1599. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930511289&partnerID=MN8TOARS.
    10.1038/cdd.2014.68
  34. Novais, A.; Ferreira, A.C.; Marques, F.; Pêgo, J.M.; Cerqueira, J.J.; David-Pereira, A.; Campos, F.L.; et al. "Neudesin is involved in anxiety behavior: Structural and neurochemical correlates". Frontiers in Behavioral Neuroscience SEP (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884698302&partnerID=MN8TOARS.
    10.3389/fnbeh.2013.00119
  35. Ferreira, A.C.; Pinto, V.; Dá Mesquita, S.; Novais, A.; Sousa, J.C.; Correia-Neves, M.; Sousa, N.; Palha, J.A.; Marques, F.. "Lipocalin-2 is involved in emotional behaviors and cognitive function". Frontiers in Cellular Neuroscience JUL (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880139680&partnerID=MN8TOARS.
    10.3389/fncel.2013.00122
  36. Marques, F.; Rodrigues, A.-J.; Sousa, J.C.; Coppola, G.; Geschwind, D.H.; Sousa, N.; Correia-Neves, M.; Palha, J.A.. "Erratum: Lipocalin 2 is a choroid plexus acute-phase protein (Journal of Cerebral Blood Flow and Metabolism (2008) 28 (450-455) DOI: 10.1038/sj.jcbfm. 9600557)". Journal of Cerebral Blood Flow and Metabolism 33 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874590597&partnerID=MN8TOARS.
    10.1038/jcbfm.2012.170
  37. Marques, F.; Sousa, J.C.; Sousa, N.; Palha, J.A.. "Blood-brain-barriers in aging and in Alzheimer's disease". Molecular Neurodegeneration 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84886907892&partnerID=MN8TOARS.
    10.1186/1750-1326-8-38
  38. Falcão, Ana Mendanha; Marques, Fernanda; Novais, Ashley; Sousa, Nuno; Palha, Joana A.; sousa, joao carlos. "The path from the choroid plexus to the subventricular zone: go with the flow!". Frontiers in cellular neuroscience 6 (2012): 34-34.
    10.3389/fncel.2012.00034
  39. Palha, Joana A.; Santos, Nadine C.; Marques, Fernanda; Sousa, João; Bessa, João; Miguelote, Rui; Sousa, Nuno; Belmonte-de-Abreu, Paulo. "Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia". Frontiers in cellular neuroscience 6 (2012): 31-31.
    10.3389/fncel.2012.00031
  40. Marques, Fernanda; Mesquita, Sandro D.; Sousa, João C.; Coppola, Giovanni; Gao, Fuying; Geschwind, Daniel H.; Columba-Cabezas, Sandra; et al. "Lipocalin 2 is present in the EAE brain and is modulated by natalizumab". Frontiers in cellular neuroscience 6 (2012): 33-33.
    10.3389/fncel.2012.00033
  41. Falcão, A.M.; Palha, J.A.; Ferreira, A.C.; Marques, F.; Sousa, N.; Sousa, J.C.. "Topographical analysis of the subependymal zone neurogenic niche". PLoS ONE 7 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84862654912&partnerID=MN8TOARS.
    10.1371/journal.pone.0038647
  42. Ventura-Silva, A.P.; Pêgo, J.M.; Sousa, J.C.; Marques, A.R.; Rodrigues, A.J.; Marques, F.; Cerqueira, J.J.; Almeida, O.F.X.; Sousa, N.. "Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode". European Journal of Neuroscience 36 10 (2012): 3396-3406. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869884316&partnerID=MN8TOARS.
    10.1111/j.1460-9568.2012.08262.x
  43. Mesquita, S.D.; Ferreira, A.C.; Sousa, J.C.; Santos, N.C.; Correia-Neves, M.; Sousa, N.; Palha, J.A.; Marques, F.. "Modulation of iron metabolism in aging and in Alzheimer's disease: Relevance of the choroid plexus". Frontiers in Cellular Neuroscience MAY 2012 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863994297&partnerID=MN8TOARS.
    10.3389/fncel.2012.00025
  44. Marques, Fernanda; Sousa, João C.; Coppola, Giovanni; Gao, Fuying; Puga, Renato; Brentani, Helena; Geschwind, Daniel H.; et al. "Transcriptome signature of the adult mouse choroid plexus". Fluids and barriers of the CNS 8 1 (2011): 10-10. http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21349147&retmode=ref&cmd=prlinks.
    papers2://publication/doi/10.1186/2045-8118-8-10
  45. Marques, F.; Sousa, J.C.; Coppola, G.; Gao, F.; Puga, R.; Brentani, H.; Geschwind, D.H.; et al. "Transcriptome signature of the adult mouse choroid plexus". Fluids and Barriers of the CNS 8 1 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80051724911&partnerID=MN8TOARS.
    10.1186/2045-8118-8-10
  46. Marques, Fernanda; Correia-Neves, Margarida; Sousa, Joao Carlos; Sousa, Nuno; Palha, Joana Almeida. "Brain Barriers and the Acute-Phase Response". Acute Phase Proteins - Regulation and Functions of Acute Phase Proteins (2011): https://publons.com/publon/30482394/.
    10.5772/22780
  47. Dias-Ferreira, Eduardo; Sousa, Joao C.; Jin, Xin; Cerqueira, Joao J.; Sousa, Nuno; Costa, Rui M.. "Stressing out Decisions". Alcohol (2011): https://publons.com/publon/8618011/.
  48. Sousa, J.C.; Costa, M.J.; Palha, J.A.. "Teaching the extracellular matrix and introducing online databases within a multidisciplinary course with i-cell-MATRIX". Biochemistry and Molecular Biology Education 38 2 (2010): 79-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949339077&partnerID=MN8TOARS.
    10.1002/bmb.20338
  49. Dias-Ferreira, E.; Sousa, J.C.; Melo, I.; Morgado, P.; Mesquita, A.R.; Cerqueira, J.J.; Costa, R.M.; Sousa, N.. "Chronic stress causes frontostriatal reorganization and affects decision-making". Science 325 5940 (2009): 621-625. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149154708&partnerID=MN8TOARS.
    10.1126/science.1171203
  50. Marques, F.; Falcao, A.M.; Sousa, J.C.; Coppola, G.; Geschwind, D.; Sousa, N.; Correia-Neves, M.; Palha, J.A.. "Altered iron metabolism is part of the choroid plexus response to peripheral inflammation". Endocrinology 150 6 (2009): 2822-2828. http://www.scopus.com/inward/record.url?eid=2-s2.0-66649091212&partnerID=MN8TOARS.
    10.1210/en.2008-1610
  51. Marques, F.; Sousa, J.C.; Coppola, G.; Geschwind, D.H.; Sousa, N.; Palha, J.A.; Correia-Neves, M.. "The choroid plexus response to a repeated peripheral inflammatory stimulus". BMC Neuroscience 10 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-71549130733&partnerID=MN8TOARS.
    10.1186/1471-2202-10-135
  52. Marques, F.; Sousa, J.C.; Coppola, G.; Falcao, A.M.; Rodrigues, A.J.; Geschwind, D.H.; Sousa, N.; Correia-Neves, M.; Palha, J.A.. "Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation". Journal of Cerebral Blood Flow and Metabolism 29 5 (2009): 921-932. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549167413&partnerID=MN8TOARS.
    10.1038/jcbfm.2009.15
  53. Costa, Manuel Joao; Goncalves, Leonor; Ludovico, Paula; Oliveira, Mario; Rodrigues, Fernando; Sousa, Joao Carlos. "Mismatches between the conceptual level of tests and faculty beliefs". The FASEB Journal (2009): https://publons.com/publon/29409458/.
  54. SILVA, R; MESQUITA, AR; BESSA, J; SOUSA, JC; SOTIROPOULOS, I; LEAO, P; ALMEIDA, OFX; SOUSA, N. "Lithium blocks stress-induced changes in depressive-like behavior and hippocampal cell fate: The role of glycogen-synthase-kinase-3 beta". Neuroscience 152 3 (2008): 656-669.
    10.1016/j.neuroscience.2007.12.026
  55. Marques, F.; Rodrigues, A.-J.; Sousa, J.C.; Coppola, G.; Geschwind, D.H.; Sousa, N.; Correia-Neves, M.; Palha, J.A.. "Lipocalin 2 is a choroid plexus acute-phase protein". Journal of Cerebral Blood Flow and Metabolism 28 3 (2008): 450-455. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749163342&partnerID=MN8TOARS.
    10.1038/sj.jcbfm.9600557
  56. Sousa, J.C.; Marques, F.; Dias-Ferreira, E.; Cerqueira, J.J.; Sousa, N.; Palha, J.A.. "Transthyretin influences spatial reference memory". Neurobiology of Learning and Memory 88 3 (2007): 381-385. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548286470&partnerID=MN8TOARS.
    10.1016/j.nlm.2007.07.006
  57. Sousa, J.C.; Cardoso, I.; Marques, F.; Saraiva, M.J.; Palha, J.A.. "Transthyretin and Alzheimer's disease: Where in the brain?". Neurobiology of Aging 28 5 (2007): 713-718. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847345982&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2006.03.015
  58. SOUSA, JC; MARQUES, F; DIAS-FERREIRA, E; CERQUEIRA, JJ; SOUSA, N; PALHA, JA. "Transthyretin influences spatial reference memory". Neurobiology of Learning and Memory 88 3 (2007): 381-385. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000249946700012&KeyUID=WOS:000249946700012.
    10.1016/j.nim.2007.07.006
  59. Leao, P.; Sousa, J.C.; Oliveira, M.; Silva, R.; Almeida, O.F.X.; Sousa, N.. "Programming effects of antenatal dexamethasone in the developing mesolimbic pathways". Synapse 61 1 (2007): 40-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845533995&partnerID=MN8TOARS.
    10.1002/syn.20341
  60. Sousa, J.C.; Costa, M.J.; Palha, J.A.. "Hormone-mediated gene regulation and bioinformatics: Learning one from the other". PLoS ONE 2 5 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-56149098745&partnerID=MN8TOARS.
    10.1371/journal.pone.0000481
  61. Marques, F.; Sousa, J.C.; Correia-Neves, M.; Oliveira, P.; Sousa, N.; Palha, J.A.. "The choroid plexus response to peripheral inflammatory stimulus". Neuroscience 144 2 (2007): 424-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845310881&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2006.09.029
  62. Marques, F.; Sousa, J.C.; Oliveira, P.; Oliveira, H.C.F.; Palha, J.A.. "The absence of transthyretin does not impair regulation of lipid and glucose metabolism". Hormone and Metabolic Research 39 7 (2007): 529-533. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547643226&partnerID=MN8TOARS.
    10.1055/s-2007-984395
  63. Sousa, J.C.; Morreale de Escobar, G.; Oliveira, P.; Saraiva, M.J.; Palha, J.A.. "Transthyretin is not necessary for thyroid hormone metabolism in conditions of increased hormone demand". Journal of Endocrinology 187 2 (2005): 257-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-28044432318&partnerID=MN8TOARS.
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  64. SOUSA, JC; GRANDELA, C; FERNANDEZ-RUIZ, J; DE MIGUEL, R; DE SOUSA, L; MAGALHAES, AI; SARAIVA, MJ; SOUSA, N; PALHA, JA. "Transthyretin is involved in depression-like behaviour and exploratory activity". Journal of Neurochemistry 88 5 (2004): 1052-1058.
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  65. Marques, F; Sousa, JC; de Oliveira, HFC; Sousa, N; Saraiva, MJ; Palha, JA. "The absence of transthyretin influences mouse fat and glucose metabolism". Atherosclerosis Supplements (2004): https://publons.com/publon/8618025/.
  66. PALHA, JA; NISSANOV, J; FERNANDES, R; SOUSA, JC; BERTRAND, L; DRATMAN, MB; DE ESCOBAR, GM; GOTTESMANE, M; SARAIVA, MJ. "Thyroid hormone distribution in the mouse brain: The role of transthyretin". Neuroscience 113 4 (2002): 837-847. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000177966700010&KeyUID=WOS:000177966700010.
  67. Palha, J.A; Nissanov, J.; Fernandes, R.; Sousa, J.C.; Bertrand, L.; Dratman, M.B.; Morreale de Escobar, G.; Gottesman, M.; Saraiva, M.J.. "Thyroid hormone distribution in the mouse brain: The role of transthyretin". Neuroscience 113 4 (2002): 837-847. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037056057&partnerID=MN8TOARS.
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Livro
  1. Marques, F.; Sousa, J.C.; Cerqueira, J.J.; Sousa, N.. Detection of the glucocorticoid receptors in brain protein extracts by SDS-PAGE. 2014.
    10.1007/978-1-4939-1346-6_20
  2. Falcão, A.M.; Palha, J.A.; Ferreira, A.C.; Marques, F.; Sousa, N.; Sousa, J.C.. Unbiased stereological method to assess proliferation throughout the subependymal zone. 2013.
    10.1007/978-1-62703-508-8_12
  3. Ventura-Silva, A.P.; Sousa, J.C.; Almeida, O.F.X.; Sousa, N.; Pêgo, J.M.. An integrated perspective on the role of the amygdala and bed nucleus of the stria terminalis in the regulation of stress responses. 2012.
  4. Pêgo, J.M.; Sousa, J.C.; Almeida, O.F.X.; Sousa, N.. Stress and the neuroendocrinology of anxiety disorders. 2010.
    10.1007/7854_2009_13
  5. Sousa, J.C.; Palha, J.A.. What have we learned from TTR-null mice: Novel functions for TTR?. 2009.
    10.1007/978-3-642-00646-3_17
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020 - Atual Exploring mycobacteria carbohydrates to develop new tuberculosis diagnostic tools.
Orientador de Carolina Sousa Silva
 Medicina (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
2017 - 2017 Dissecting lipocalin-2 as a novel modulator of brain processes
Orientador
 Ciências da Saúde (Doutoramento)
Universidade do Minho, Portugal
2016 - 2016 Individual performence in cognitive aging and deficit prevention by cognitive training in the rat: integration of structural, molecular and functional correlates.
Orientador
 Ciências da Saúde (Doutoramento)
Universidade do Minho, Portugal
2016 - 2016 The role of N-Glicans in the structure and function of the C. Elegans nervous system
Orientador
 Ciências da Saúde (Mestrado)
Universidade do Minho, Portugal
2016 - 2016 The impact of choroid plexus derived factors in the subventricular zone neural progebitor cells niche
Orientador
 Ciências da Saúde (Mestrado)
Universidade do Minho, Portugal
2011 - 2011 Unraveling the biological role of neudesin, a novel neurotrophic factor
Orientador
 Ciências da Saúde (Doutoramento)
Universidade do Minho, Portugal
2009 - 2009 Novel perspectives on the subependymal zone complexity and modulation
Orientador
 Ciências da Saúde (Doutoramento)
Universidade do Minho, Portugal