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Identificação

Identificação pessoal

Nome completo
Silke Leimkuehler

Nomes de citação

  • Leimkuehler, Silke

Identificadores de autor

Ciência ID
2E17-9758-83C7
ORCID iD
0000-0003-3238-2122
Produções

Publicações

Artigo em revista
  1. Terao M; Garattini E; Romão MJ; Leimkühler S. "Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes.". The Journal of biological chemistry (2020): http://europepmc.org/abstract/med/32144208.
    10.1074/jbc.rev119.007741
  2. Duffus BR; Schrapers P; Schuth N; Mebs S; Dau H; Leimkühler S; Haumann M. "Anion Binding and Oxidative Modification at the Molybdenum Cofactor of Formate Dehydrogenase from Rhodobacter capsulatus Studied by X-ray Absorption Spectroscopy.". Inorganic chemistry (2019): http://europepmc.org/abstract/med/31814403.
    10.1021/acs.inorgchem.9b01613
  3. Zupok A; Iobbi-Nivol C; Méjean V; Leimkühler S. "The regulation of Moco biosynthesis and molybdoenzyme gene expression by molybdenum and iron in bacteria.". Metallomics : integrated biometal science (2019): http://europepmc.org/abstract/med/31517366.
    10.1039/c9mt00186g
  4. Zupok A; Gorka M; Siemiatkowska B; Skirycz A; Leimkühler S. "Iron-Dependent Regulation of Molybdenum Cofactor Biosynthesis Genes in Escherichia coli.". Journal of bacteriology (2019): http://europepmc.org/abstract/med/31235512.
    10.1128/JB.00382-19
  5. Tanabe TS; Leimkühler S; Dahl C. "The functional diversity of the prokaryotic sulfur carrier protein TusA.". Advances in microbial physiology (2019): http://europepmc.org/abstract/med/31655739.
    10.1016/bs.ampbs.2019.07.004
  6. Lemaire ON; Honoré FA; Tempel S; Fortier EM; Leimkühler S; Méjean V; Iobbi-Nivol C. "Shewanella decolorationis LDS1 Chromate Resistance.". Applied and environmental microbiology (2019): http://europepmc.org/abstract/med/31300400.
    10.1128/AEM.00777-19
  7. Reschke S; Duffus BR; Schrapers P; Mebs S; Teutloff C; Dau H; Haumann M; Leimkühler S. "Identification of YdhV as the First Molybdoenzyme Binding a Bis-Mo-MPT Cofactor in Escherichia coli.". Biochemistry (2019): http://europepmc.org/abstract/med/30945846.
    10.1021/acs.biochem.9b00078
  8. Mota C; Esmaeeli M; Coelho C; Santos-Silva T; Wolff M; Foti A; Leimkühler S; Romão MJ. "Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms.". FEBS open bio (2019): http://europepmc.org/abstract/med/30985987.
    10.1002/2211-5463.12617
  9. Neukranz Y; Kotter A; Beilschmidt L; Marelja Z; Helm M; Gräf R; Leimkühler S. "Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome.". Biochemistry (2019): http://europepmc.org/abstract/med/30817134.
    10.1021/acs.biochem.8b01160
  10. Riedel S; Siemiatkowska B; Watanabe M; Müller CS; Schünemann V; Hoefgen R; Leimkühler S. "The ABCB7-Like Transporter PexA in Rhodobacter capsulatus Is Involved in the Translocation of Reactive Sulfur Species.". Frontiers in microbiology (2019): http://europepmc.org/abstract/med/30918498.
    10.3389/fmicb.2019.00406
  11. Kaufmann P; Iobbi-Nivol C; Leimkühler S. "Reconstitution of Molybdoenzymes with Bis-Molybdopterin Guanine Dinucleotide Cofactors.". Methods in molecular biology (Clifton, N.J.) (2019): http://europepmc.org/abstract/med/30317479.
    10.1007/978-1-4939-8864-8_9
  12. Schwanhold N; Iobbi-Nivol C; Lehmann A; Leimkühler S. "Same but different: Comparison of two system-specific molecular chaperones for the maturation of formate dehydrogenases.". PloS one (2018): http://europepmc.org/abstract/med/30444874.
    10.1371/journal.pone.0201935
  13. Burschel S; Kreuzer Decovic D; Nuber F; Stiller M; Hofmann M; Zupok A; Siemiatkowska B; et al. "Iron-sulfur cluster carrier proteins involved in the assembly of Escherichia coli NADH:ubiquinone oxidoreductase (complex I).". Molecular microbiology (2018): http://europepmc.org/abstract/med/30251413.
    10.1111/mmi.14137
  14. Lemaire ON; Infossi P; Ali Chaouche A; Espinosa L; Leimkühler S; Giudici-Orticoni MT; Méjean V; Iobbi-Nivol C. "Small membranous proteins of the TorE/NapE family, crutches for cognate respiratory systems in Proteobacteria.". Scientific reports (2018): http://europepmc.org/abstract/med/30206249.
    10.1038/s41598-018-31851-2
  15. Otto N; Marelja Z; Schoofs A; Kranenburg H; Bittern J; Yildirim K; Berh D; et al. "The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia.". Nature communications (2018): http://europepmc.org/abstract/med/30158546.
    10.1038/s41467-018-05645-z
  16. Öner IH; Querebillo CJ; David C; Gernert U; Walter C; Driess M; Leimkühler S; Ly KH; Weidinger IM. "High Electromagnetic Field Enhancement of TiO2 Nanotube Electrodes.". Angewandte Chemie (International ed. in English) (2018): http://europepmc.org/abstract/med/29573138.
    10.1002/anie.201802597
  17. Kaufmann P; Duffus BR; Teutloff C; Leimkühler S. "Functional Studies on Oligotropha carboxidovorans Molybdenum-Copper CO Dehydrogenase Produced in Escherichia coli.". Biochemistry (2018): http://europepmc.org/abstract/med/29676148.
    10.1021/acs.biochem.8b00128
  18. Marelja Z; Leimkühler S; Missirlis F. "Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism.". Frontiers in Physiology (2018): http://europepmc.org/abstract/med/29491838.
    10.3389/fphys.2018.00050
  19. Kücükgöze G; Leimkühler S. "Direct comparison of the four aldehyde oxidase enzymes present in mouse gives insight into their substrate specificities.". PloS one (2018): http://europepmc.org/abstract/med/29370288.
    10.1371/journal.pone.0191819
  20. Kaufmann P; Duffus BR; Mitrova B; Iobbi-Nivol C; Teutloff C; Nimtz M; Jänsch L; Wollenberger U; Leimkühler S. "Modulating the Molybdenum Coordination Sphere of Escherichia coli Trimethylamine N-Oxide Reductase.". Biochemistry (2018): http://europepmc.org/abstract/med/29334455.
    10.1021/acs.biochem.7b01108
  21. Brietzke T; Dietz T; Kelling A; Schilde U; Bois J; Kelm H; Reh M; et al. "The 1,6,7,12-Tetraazaperylene Bridging Ligand as an Electron Reservoir and Its Disulfonato Derivative as Redox Mediator in an Enzyme-Electrode Process.". Chemistry (Weinheim an der Bergstrasse, Germany) (2017): http://europepmc.org/abstract/med/28869692.
    10.1002/chem.201703639
  22. Bühning M; Friemel M; Leimkühler S. "Functional Complementation Studies Reveal Different Interaction Partners of Escherichia coli IscS and Human NFS1.". Biochemistry (2017): http://europepmc.org/abstract/med/28766335.
    10.1021/acs.biochem.7b00627
  23. Paragas EM; Humphreys SC; Min J; Joswig-Jones CA; Leimkühler S; Jones JP. "ecoAO: A Simple System for the Study of Human Aldehyde Oxidases Role in Drug Metabolism.". ACS omega (2017): http://europepmc.org/abstract/med/28884164.
    10.1021/acsomega.7b01054
  24. Leimkühler S. "Shared function and moonlighting proteins in molybdenum cofactor biosynthesis.". Biological chemistry (2017): http://europepmc.org/abstract/med/28284029.
    10.1515/hsz-2017-0110
  25. Zeng T; Leimkühler S; Wollenberger U; Fourmond V. "Transient Catalytic Voltammetry of Sulfite Oxidase Reveals Rate Limiting Conformational Changes.". Journal of the American Chemical Society (2017): http://europepmc.org/abstract/med/28727916.
    10.1021/jacs.7b05480
  26. Foti A; Dorendorf F; Leimkühler S. "A single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase.". PloS one (2017): http://europepmc.org/abstract/med/28750088.
    10.1371/journal.pone.0182061
  27. Dong C; Yang J; Reschke S; Leimkühler S; Kirk ML. "Vibrational Probes of Molybdenum Cofactor-Protein Interactions in Xanthine Dehydrogenase.". Inorganic chemistry (2017): http://europepmc.org/abstract/med/28590138.
    10.1021/acs.inorgchem.7b00028
  28. Kücükgöze G; Terao M; Garattini E; Leimkühler S. "Direct Comparison of the Enzymatic Characteristics and Superoxide Production of the Four Aldehyde Oxidase Enzymes Present in Mouse.". Drug metabolism and disposition: the biological fate of chemicals (2017): http://europepmc.org/abstract/med/28526768.
    10.1124/dmd.117.075937
  29. Friemel M; Marelja Z; Li K; Leimkühler S. "The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1.". Biochemistry (2017): http://europepmc.org/abstract/med/28271877.
    10.1021/acs.biochem.6b01239
  30. Bühning M; Valleriani A; Leimkühler S. "The Role of SufS Is Restricted to Fe-S Cluster Biosynthesis in Escherichia coli.". Biochemistry (2017): http://europepmc.org/abstract/med/28323419.
    10.1021/acs.biochem.7b00040
  31. Reschke S; Mebs S; Sigfridsson-Clauss KG; Kositzki R; Leimkühler S; Haumann M. "Protonation and Sulfido versus Oxo Ligation Changes at the Molybdenum Cofactor in Xanthine Dehydrogenase (XDH) Variants Studied by X-ray Absorption Spectroscopy.". Inorganic chemistry (2017): http://europepmc.org/abstract/med/28170236.
    10.1021/acs.inorgchem.6b02846
  32. Leimkühler S; Bühning M; Beilschmidt L. "Shared Sulfur Mobilization Routes for tRNA Thiolation and Molybdenum Cofactor Biosynthesis in Prokaryotes and Eukaryotes.". Biomolecules (2017): http://europepmc.org/abstract/med/28098827.
    10.3390/biom7010005
  33. Romão MJ; Coelho C; Santos-Silva T; Foti A; Terao M; Garattini E; Leimkühler S. "Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics.". Current opinion in chemical biology (2017): http://europepmc.org/abstract/med/28126656.
    10.1016/j.cbpa.2017.01.005
  34. Han XX; Li J; Öner IH; Zhao B; Leimkühler S; Hildebrandt P; Weidinger IM. "Nickel electrodes as a cheap and versatile platform for studying structure and function of immobilized redox proteins.". Analytica chimica acta (2016): http://europepmc.org/abstract/med/27692376.
    10.1016/j.aca.2016.08.053
  35. Correia MA; Otrelo-Cardoso AR; Schwuchow V; Sigfridsson Clauss KG; Haumann M; Romão MJ; Leimkühler S; Santos-Silva T. "The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes.". ACS chemical biology (2016): http://europepmc.org/abstract/med/27622978.
    10.1021/acschembio.6b00572
  36. Yan R; Friemel M; Aloisi C; Huynen M; Taylor IA; Leimkühler S; Pastore A. "The Eukaryotic-Specific ISD11 Is a Complex-Orphan Protein with Ability to Bind the Prokaryotic IscS.". PloS one (2016): http://europepmc.org/abstract/med/27427956.
    10.1371/journal.pone.0157895
  37. Hartmann T; Schrapers P; Utesch T; Nimtz M; Rippers Y; Dau H; Mroginski MA; Haumann M; Leimkühler S. "The Molybdenum Active Site of Formate Dehydrogenase Is Capable of Catalyzing C-H Bond Cleavage and Oxygen Atom Transfer Reactions.". Biochemistry (2016): http://europepmc.org/abstract/med/27054466.
    10.1021/acs.biochem.6b00002
  38. Cazelles R; Lalaoui N; Hartmann T; Leimkühler S; Wollenberger U; Antonietti M; Cosnier S. "Ready to use bioinformatics analysis as a tool to predict immobilisation strategies for protein direct electron transfer (DET).". Biosensors & bioelectronics (2016): http://europepmc.org/abstract/med/27156017.
    10.1016/j.bios.2016.04.078
  39. Terao M; Romão MJ; Leimkühler S; Bolis M; Fratelli M; Coelho C; Santos-Silva T; Garattini E. "Structure and function of mammalian aldehyde oxidases.". Archives of toxicology (2016): http://europepmc.org/abstract/med/26920149.
    10.1007/s00204-016-1683-1
  40. Foti A; Hartmann T; Coelho C; Santos-Silva T; Romão MJ; Leimkühler S. "Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms.". Drug metabolism and disposition: the biological fate of chemicals (2016): http://europepmc.org/abstract/med/26842593.
    10.1124/dmd.115.068395
  41. Pinyou P; Ruff A; Pöller S; Alsaoub S; Leimkühler S; Wollenberger U; Schuhmann W. "Wiring of the aldehyde oxidoreductase PaoABC to electrode surfaces via entrapment in low potential phenothiazine-modified redox polymers.". Bioelectrochemistry (Amsterdam, Netherlands) (2015): http://europepmc.org/abstract/med/26775204.
    10.1016/j.bioelechem.2015.12.005
  42. Leimkühler S; Iobbi-Nivol C. "Bacterial molybdoenzymes: old enzymes for new purposes.". FEMS microbiology reviews (2015): http://europepmc.org/abstract/med/26468212.
    10.1093/femsre/fuv043
  43. Zeng T; Leimkühler S; Koetz J; Wollenberger U. "Effective Electrochemistry of Human Sulfite Oxidase Immobilized on Quantum-Dots-Modified Indium Tin Oxide Electrode.". ACS applied materials & interfaces (2015): http://europepmc.org/abstract/med/26357959.
    10.1021/acsami.5b06665
  44. Hahn A; Engelhard C; Reschke S; Teutloff C; Bittl R; Leimkühler S; Risse T. "Structural Insights into the Incorporation of the Mo Cofactor into Sulfite Oxidase from Site-Directed Spin Labeling.". Angewandte Chemie (International ed. in English) (2015): http://europepmc.org/abstract/med/26286921.
    10.1002/anie.201504772
  45. Coelho C; Foti A; Hartmann T; Santos-Silva T; Leimkühler S; Romão MJ. "Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase.". Nature chemical biology (2015): http://europepmc.org/abstract/med/26322824.
    10.1038/nchembio.1895
  46. Schrapers P; Hartmann T; Kositzki R; Dau H; Reschke S; Schulzke C; Leimkühler S; Haumann M. "Sulfido and cysteine ligation changes at the molybdenum cofactor during substrate conversion by formate dehydrogenase (FDH) from Rhodobacter capsulatus.". Inorganic chemistry (2015): http://europepmc.org/abstract/med/25803130.
    10.1021/ic502880y
  47. Hartmann T; Schwanhold N; Leimkühler S. "Assembly and catalysis of molybdenum or tungsten-containing formate dehydrogenases from bacteria.". Biochimica et biophysica acta (2014): http://europepmc.org/abstract/med/25514355.
    10.1016/j.bbapap.2014.12.006
  48. Badalyan A; Dierich M; Stiba K; Schwuchow V; Leimkühler S; Wollenberger U. "Electrical Wiring of the Aldehyde Oxidoreductase PaoABC with a Polymer Containing Osmium Redox Centers: Biosensors for Benzaldehyde and GABA.". Biosensors (2014): http://europepmc.org/abstract/med/25587431.
    10.3390/bios4040403
  49. Zeng T; Pankratov D; Falk M; Leimkühler S; Shleev S; Wollenberger U. "Miniature direct electron transfer based sulphite/oxygen enzymatic fuel cells.". Biosensors & bioelectronics (2014): http://europepmc.org/abstract/med/25460879.
    10.1016/j.bios.2014.10.080
  50. Fräsdorf B; Radon C; Leimkühler S. "Characterization and interaction studies of two isoforms of the dual localized 3-mercaptopyruvate sulfurtransferase TUM1 from humans.". The Journal of biological chemistry (2014): http://europepmc.org/abstract/med/25336638.
    10.1074/jbc.M114.605733
  51. Hall J; Reschke S; Cao H; Leimkühler S; Hille R. "The reductive half-reaction of xanthine dehydrogenase from Rhodobacter capsulatus: the role of Glu232 in catalysis.". The Journal of biological chemistry (2014): http://europepmc.org/abstract/med/25258317.
    10.1074/jbc.M114.603456
  52. Yokoyama K; Leimkühler S. "The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria.". Biochimica et biophysica acta (2014): http://europepmc.org/abstract/med/25268953.
    10.1016/j.bbamcr.2014.09.021
  53. Mendel RR; Leimkühler S. "The biosynthesis of the molybdenum cofactors.". Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry (2014): http://europepmc.org/abstract/med/24980677.
    10.1007/s00775-014-1173-y
  54. Hahn A; Reschke S; Leimkühler S; Risse T. "Ketoxime coupling of p-acetylphenylalanine at neutral pH for site-directed spin labeling of human sulfite oxidase.". The journal of physical chemistry. B (2014): http://europepmc.org/abstract/med/24902036.
    10.1021/jp503471j
  55. Dong C; Yang J; Leimkühler S; Kirk ML. "Pyranopterin dithiolene distortions relevant to electron transfer in xanthine oxidase/dehydrogenase.". Inorganic chemistry (2014): http://europepmc.org/abstract/med/24979205.
    10.1021/ic500873y
  56. Dey P; Adamovski M; Friebe S; Badalyan A; Mutihac RC; Paulus F; Leimkühler S; Wollenberger U; Haag R. "Dendritic polyglycerol-poly(ethylene glycol)-based polymer networks for biosensing application.". ACS applied materials & interfaces (2014): http://europepmc.org/abstract/med/24882361.
    10.1021/am502018x
  57. Marelja Z; Dambowsky M; Bolis M; Georgiou ML; Garattini E; Missirlis F; Leimkühler S. "The four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificities.". The Journal of experimental biology (2014): http://europepmc.org/abstract/med/24737760.
    10.1242/jeb.102129
  58. Otrelo-Cardoso AR; da Silva Correia MA; Schwuchow V; Svergun DI; Romão MJ; Leimkühler S; Santos-Silva T. "Structural data on the periplasmic aldehyde oxidoreductase PaoABC from Escherichia coli: SAXS and preliminary X-ray crystallography analysis.". International journal of molecular sciences (2014): http://europepmc.org/abstract/med/24492481.
    10.3390/ijms15022223
  59. Otrelo-Cardoso AR; Schwuchow V; Rodrigues D; Cabrita EJ; Leimkühler S; Romão MJ; Santos-Silva T. "Biochemical, stabilization and crystallization studies on a molecular chaperone (PaoD) involved in the maturation of molybdoenzymes.". PloS one (2014): http://europepmc.org/abstract/med/24498065.
    10.1371/journal.pone.0087295
  60. Böhmer N; Hartmann T; Leimkühler S. "The chaperone FdsC for Rhodobacter capsulatus formate dehydrogenase binds the bis-molybdopterin guanine dinucleotide cofactor.". FEBS letters (2014): http://europepmc.org/abstract/med/24444607.
    10.1016/j.febslet.2013.12.033
  61. Mahro M; Brás NF; Cerqueira NM; Teutloff C; Coelho C; Romão MJ; Leimkühler S. "Identification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificity.". PloS one (2013): http://europepmc.org/abstract/med/24358164.
    10.1371/journal.pone.0082285
  62. Reschke S; Niks D; Wilson H; Sigfridsson KG; Haumann M; Rajagopalan KV; Hille R; Leimkühler S. "Effect of exchange of the cysteine molybdenum ligand with selenocysteine on the structure and function of the active site in human sulfite oxidase.". Biochemistry (2013): http://europepmc.org/abstract/med/24147957.
    10.1021/bi4008512
  63. Hartmann T; Leimkühler S. "The oxygen-tolerant and NAD+-dependent formate dehydrogenase from Rhodobacter capsulatus is able to catalyze the reduction of CO2 to formate.". The FEBS journal (2013): http://europepmc.org/abstract/med/24034888.
    10.1111/febs.12528
  64. Reschke S; Sigfridsson KG; Kaufmann P; Leidel N; Horn S; Gast K; Schulzke C; Haumann M; Leimkühler S. "Identification of a bis-molybdopterin intermediate in molybdenum cofactor biosynthesis in Escherichia coli.". The Journal of biological chemistry (2013): http://europepmc.org/abstract/med/24003231.
    10.1074/jbc.M113.497453
  65. Warelow TP; Oke M; Schoepp-Cothenet B; Dahl JU; Bruselat N; Sivalingam GN; Leimkühler S; et al. "The respiratory arsenite oxidase: structure and the role of residues surrounding the rieske cluster.". PloS one (2013): http://europepmc.org/abstract/med/24023621.
    10.1371/journal.pone.0072535
  66. Lim SC; Friemel M; Marum JE; Tucker EJ; Bruno DL; Riley LG; Christodoulou J; et al. "Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes.". Human molecular genetics (2013): http://europepmc.org/abstract/med/23814038.
    10.1093/hmg/ddt295
  67. Marelja Z; Mullick Chowdhury M; Dosche C; Hille C; Baumann O; Löhmannsröben HG; Leimkühler S. "The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans.". PloS one (2013): http://europepmc.org/abstract/med/23593335.
    10.1371/journal.pone.0060869
  68. Dahl JU; Radon C; Bühning M; Nimtz M; Leichert LI; Denis Y; Jourlin-Castelli C; et al. "The sulfur carrier protein TusA has a pleiotropic role in Escherichia coli that also affects molybdenum cofactor biosynthesis.". The Journal of biological chemistry (2013): http://europepmc.org/abstract/med/23281480.
    10.1074/jbc.M112.431569
  69. Kalimuthu P; Leimkühler S; Bernhardt PV. "Low-potential amperometric enzyme biosensor for xanthine and hypoxanthine.". Analytical chemistry (2012): http://europepmc.org/abstract/med/23134312.
    10.1021/ac3025027
  70. Iobbi-Nivol C; Leimkühler S. "Molybdenum enzymes, their maturation and molybdenum cofactor biosynthesis in Escherichia coli.". Biochimica et biophysica acta (2012): http://europepmc.org/abstract/med/23201473.
    10.1016/j.bbabio.2012.11.007
  71. Xia H; Cao Y; Dai X; Marelja Z; Zhou D; Mo R; Al-Mahdawi S; et al. "Novel frataxin isoforms may contribute to the pathological mechanism of Friedreich ataxia.". PloS one (2012): http://europepmc.org/abstract/med/23082224.
    10.1371/journal.pone.0047847
  72. Kalimuthu P; Leimkühler S; Bernhardt PV. "Catalytic electrochemistry of xanthine dehydrogenase.". The journal of physical chemistry. B (2012): http://europepmc.org/abstract/med/22934570.
    10.1021/jp307374z
  73. Coelho C; Mahro M; Trincão J; Carvalho AT; Ramos MJ; Terao M; Garattini E; Leimkühler S; Romão MJ. "The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity.". The Journal of biological chemistry (2012): http://europepmc.org/abstract/med/23019336.
    10.1074/jbc.M112.390419
  74. Rademacher C; Hoffmann MC; Lackmann JW; Moser R; Pfänder Y; Leimkühler S; Narberhaus F; Masepohl B. "Tellurite resistance gene trgB confers copper tolerance to Rhodobacter capsulatus.". Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (2012): http://europepmc.org/abstract/med/22767205.
    10.1007/s10534-012-9566-2
  75. Sivanesan A; Kalaivani G; Fischer A; Stiba K; Leimkühler S; Weidinger IM. "Complementary surface-enhanced resonance Raman spectroscopic biodetection of mixed protein solutions by chitosan- and silica-coated plasmon-tuned silver nanoparticles.". Analytical chemistry (2012): http://europepmc.org/abstract/med/22690823.
    10.1021/ac301001a
  76. Kikuchi H; Fujisaki H; Furuta T; Okamoto K; Leimkühler S; Nishino T. "Different inhibitory potency of febuxostat towards mammalian and bacterial xanthine oxidoreductases: insight from molecular dynamics.". Scientific reports (2012): http://europepmc.org/abstract/med/22448318.
    10.1038/srep00331
  77. Chowdhury MM; Dosche C; Löhmannsröben HG; Leimkühler S. "Dual role of the molybdenum cofactor biosynthesis protein MOCS3 in tRNA thiolation and molybdenum cofactor biosynthesis in humans.". The Journal of biological chemistry (2012): http://europepmc.org/abstract/med/22453920.
    10.1074/jbc.M112.351429
  78. Hartmann T; Terao M; Garattini E; Teutloff C; Alfaro JF; Jones JP; Leimkühler S. "The impact of single nucleotide polymorphisms on human aldehyde oxidase.". Drug metabolism and disposition: the biological fate of chemicals (2012): http://europepmc.org/abstract/med/22279051.
    10.1124/dmd.111.043828
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