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Identificação

Identificação pessoal

Nome completo
Ana Eulalio

Nomes de citação

  • Eulalio, Ana

Identificadores de autor

Ciência ID
2914-605B-D977
ORCID iD
0000-0002-7355-0674
Researcher Id
D-3083-2013
Scopus Author Id
22934396800

Moradas

  • Center for Neuroscience and Cell Biology (CNC), University of Coimbra. UC-BIOTECH, Parque Tecnologico de Cantanhede, Nucleo 04, Lote 08, 3060-197, Cantanhede, Cantanhede, Portugal (Profissional)

Websites

  • http://www.cnbc.pt/research/department_group_show.asp?iddep=1106&idgrp=1836&idseccao=38 (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Microbiologia
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
Produções

Publicações

Artigo em revista
  1. Carmen Aguilar; Susana Costa; Claire Maudet; R. P. Vivek-Ananth; Sara Zaldívar-López; Juan J. Garrido; Areejit Samal; Miguel Mano; Ana Eulalio. "Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells". Nature Communications (2021): https://doi.org/10.1038/s41467-021-23593-z.
    10.1038/s41467-021-23593-z
  2. Aguilar, C.; Cruz, A.R.; Rodrigues Lopes, I.; Maudet, C.; Sunkavalli, U.; Silva, R.J.; Sharan, M.; et al. "Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection". Nature Microbiology 5 1 (2020): 192-205.
    10.1038/s41564-019-0614-3
  3. Rodrigues Lopes, I.; Silva, R.J.; Caramelo, I.; Mano, M.; Eulalio, A.. "Shedding light on microRNA function via microscopy-based screening". Methods (2019):
    10.1016/j.ymeth.2018.09.011
  4. Aguilar, C.; Mano, M.; Eulalio, A.. "MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense". Trends in Microbiology 27 3 (2019): 206-218.
    10.1016/j.tim.2018.10.011
  5. Aguilar, C.; Mano, M.; Eulalio, A.. "Multifaceted roles of microRNAs in host-bacterial pathogen interaction". Microbiology Spectrum 7 3 (2019):
    10.1128/microbiolspec.BAI-0002-2019
  6. Tawk, C.; Nigro, G.; Rodrigues Lopes, I.; Aguilar, C.; Lisowski, C.; Mano, M.; Sansonetti, P.; Vogel, J.; Eulalio, A.. "Stress-induced host membrane remodeling protects from infection by non-motile bacterial pathogens". The EMBO Journal 37 23 (2018):
    10.15252/embj.201798529
  7. Tawk, C.; Sharan, M.; Eulalio, A.; Vogel, J.. "A systematic analysis of the RNA-targeting potential of secreted bacterial effector proteins". Scientific Reports 7 1 (2017):
    10.1038/s41598-017-09527-0
  8. Sunkavalli, U.; Aguilar, C.; Silva, R.J.; Sharan, M.; Cruz, A.R.; Tawk, C.; Maudet, C.; Mano, M.; Eulalio, A.. "Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodia". PLoS Pathogens 13 4 (2017):
    10.1371/journal.ppat.1006327
  9. Chowdhury, S.R.; Reimer, A.; Sharan, M.; Kozjak-Pavlovic, V.; Eulalio, A.; Prusty, B.K.; Fraunholz, M.; Karunakaran, K.; Rudel, T.. "Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission". Journal of Cell Biology 216 4 (2017): 1071-1089.
    10.1083/jcb.201608063
  10. Sharan, M.; Forstner, K.U.; Eulalio, A.; Vogel, J.. "APRICOT: An integrated computational pipeline for the sequence-based identification and characterization of RNA-binding proteins". Nucleic Acids Research 45 11 (2017): e96-e96.
    10.1093/nar/gkx137
  11. Eulalio, A.; Mano, M.. "MicroRNA Screening and the Quest for Biologically Relevant Targets". Journal of Biomolecular Screening 20 8 (2015): 1003-1017.
    10.1177/1087057115578837
  12. Maudet, C.; Mano, M.; Sunkavalli, U.; Sharan, M.; Giacca, M.; Förstner, K.U.; Eulalio, A.. "Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection". Nature Communications 5 (2014):
    10.1038/ncomms5718
  13. Maudet, C.; Mano, M.; Eulalio, A.. "MicroRNAs in the interaction between host and bacterial pathogens". FEBS Letters 588 22 (2014): 4140-4147.
    10.1016/j.febslet.2014.08.002
  14. Huntzinger, E.; Kuzuoglu-Öztürk, D.; Braun, J.E.; Eulalio, A.; Wohlbold, L.; Izaurralde, E.. "The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets". Nucleic Acids Research 41 2 (2013): 978-994.
    10.1093/nar/gks1078
  15. Eulalio, A.; Mano, M.; Ferro, M.D.; Zentilin, L.; Sinagra, G.; Zacchigna, S.; Giacca, M.. "Functional screening identifies miRNAs inducing cardiac regeneration". Nature 492 7429 (2012): 376-381.
    10.1038/nature11739
  16. Lovric, J.; Mano, M.; Zentilin, L.; Eulalio, A.; Zacchigna, S.; Giacca, M.. "Terminal differentiation of cardiac and skeletal myocytes induces permissivity to AAV transduction by relieving inhibition imposed by DNA damage response proteins". Molecular Therapy 20 11 (2012): 2087-2097.
    10.1038/mt.2012.144
  17. Eulalio, A.; Schulte, L.N.; Voge, J.. "The mammalian microRNA response to bacterial infections". RNA Biology 9 6 (2012): 742-750.
    10.4161/rna.20018
  18. Schulte, L.N.; Eulalio, A.; Mollenkopf, H.-J.; Reinhardt, R.; Vogel, J.. "Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family". EMBO Journal 30 10 (2011): 1977-1989.
    10.1038/emboj.2011.94
  19. Eulalio, A.; Fröhlich, K.S.; Mano, M.; Giacca, M.; Vogel, J.. "A candidate approach implicates the secreted Salmonella effector protein SpvB in P-body disassembly". PLoS ONE 6 3 (2011):
    10.1371/journal.pone.0017296
  20. Heale, B.S.E.; Eulalio, A.; Schulte, L.; Vogel, J.; O'Connell, M.A.. "Analysis of a to I editing of miRNA in macrophages exposed to salmonella". RNA Biology 7 5 (2010): 621-627.
    10.4161.rna.7.5.13269
  21. Eulalio, A.; Tritschler, F.; Izaurralde, E.. "The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing". RNA 15 8 (2009): 1433-1442.
    10.1261/rna.1703809
  22. Eulalio, A.; Huntzinger, E.; Nishihara, T.; Rehwinkel, J.; Fauser, M.; Izaurralde, E.. "Deadenylation is a widespread effect of miRNA regulation". RNA 15 1 (2009): 21-32.
    10.1261/rna.1399509
  23. Eulalio, A.; Tritschler, F.; Budie;ttner, R.; Weichenrieder, O.; Izaurralde, E.; Truffault, V.. "The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing". Nucleic Acids Research 37 9 (2009): 2974-2983.
    10.1093/nar/gkp173
  24. Eulalio, A.; Helms, S.; Fritzsch, C.; Fauser, M.; Izaurralde, E.. "A C-terminal silencing domain in GW182 is essential for miRNA function". RNA 15 6 (2009): 1067-1077.
    10.1261/rna.1605509
  25. Tritschler, F.; Braun, J.E.; Eulalio, A.; Truffault, V.; Izaurralde, E.; Weichenrieder, O.. "Structural Basis for the Mutually Exclusive Anchoring of P Body Components EDC3 and Tral to the DEAD Box Protein DDX6/Me31B". Molecular Cell 33 5 (2009): 661-668.
    10.1016/j.molcel.2009.02.014
  26. Eulalio, A.; Huntzinger, E.; Izaurralde, E.. "GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay". Nature Structural and Molecular Biology 15 4 (2008): 346-353.
    10.1038/nsmb.1405
  27. Eulalio, A.; Huntzinger, E.; Izaurralde, E.. "Getting to the Root of miRNA-Mediated Gene Silencing". Cell 132 1 (2008): 9-14.
    10.1016/j.cell.2007.12.024
  28. Tritschler, F.; Eulalio, A.; Helms, S.; Schmidt, S.; Coles, M.; Weichenrieder, O.; Izaurralde, E.; Truffault, V.. "Similar modes of interaction enable trailer hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes". Molecular and Cellular Biology 28 21 (2008): 6695-6708.
    10.1128/MCB.00759-08
  29. Jinek, M.; Eulalio, A.; Lingel, A.; Helms, S.; Conti, E.; Izaurralde, E.. "The C-terminal region of Ge-1 presents conserved structural features required for P-body localization". RNA 14 10 (2008): 1991-1998.
    10.1261/rna.1222908
  30. Nunes-Correia, I.; Rodríguez, J.M.; Eulálio, A.; Carvalho, A.L.; Citovsky, V.; Simões, S.; Faro, C.; Salas, M.L.; Pedroso de Lima, M.C.. "African swine fever virus p10 protein exhibits nuclear import capacity and accumulates in the nucleus during viral infection". Veterinary Microbiology 130 1-2 (2008): 47-59.
    10.1016/j.vetmic.2007.12.010
  31. Eulalio, A.; Behm-Ansmant, I.; Schweizer, D.; Izaurralde, E.. "P-body formation is a consequence, not the cause, of RNA-mediated gene silencing". Molecular and Cellular Biology 27 11 (2007): 3970-3981.
    10.1128/MCB.00128-07
  32. Eulalio, A.; Behm-Ansmant, I.; Izaurralde, E.. "P bodies: At the crossroads of post-transcriptional pathways". Nature Reviews Molecular Cell Biology 8 1 (2007): 9-22.
    10.1038/nrm2080
  33. Eulalio, A.; Rehwinkel, J.; Stricker, M.; Huntzinger, E.; Yang, S.-F.; Doerks, T.; Dorner, S.; et al. "Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing". Genes and Development 21 20 (2007): 2558-2570.
    10.1101/gad.443107
  34. Tritschler, F.; Eulalio, A.; Truffault, V.; Hartmann, M.D.; Helms, S.; Schmidt, S.; Coles, M.; Izaurralde, E.; Weichenrieder, O.. "A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting". Molecular and Cellular Biology 27 24 (2007): 8600-8611.
    10.1128/MCB.01506-07
  35. Eulálio, A.; Nunes-Correia, I.; Salas, J.; Salas, M.L.; Simões, S.; Pedroso de Lima, M.C.. "African swine fever virus p37 structural protein is localized in nuclear foci containing the viral DNA at early post-infection times". Virus Research 130 1-2 (2007): 18-27.
    10.1016/j.virusres.2007.05.009
  36. Dorner, S.; Eulalio, A.; Huntzinger, E.; Izaurralde, E.. "Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: Biological Functions and Mechanisms". EMBO Reports 8 8 (2007): 723-729.
    10.1038/sj.embor.7401015
  37. Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Salas, J.; Salas, M.L.; Simões, S.; Pedroso De Lima, M.C.. "Nuclear export of African swine fever virus p37 protein occurs through two distinct pathways and is mediated by three independent signals". Journal of Virology 80 3 (2006): 1393-1404.
    10.1128/JVI.80.3.1393-1404.2006
  38. Eulálio, A.; Nunes-Correia, I.; Carvalho, A.L.; Faro, C.; Citovsky, V.; Simões, S.; De Lima, M.C.P.. "Two African swine fever virus proteins derived from a common precursor exhibit different nucleocytoplasmic transport activities". Journal of Virology 78 18 (2004): 9731-9739.
    10.1128/JVI.78.18.9731-9739.2004
  39. Nunes-Correia, I.; Eulálio, A.; Nir, S.; Pedroso De Lima, M.C.. "Caveolae as an additional route for influenza virus endocytosis in MDCK cells". Cellular and Molecular Biology Letters 9 1 (2004): 47-60.
  40. Nunes-Correia, I.; Eulálio, A.; Nir, S.; Düzgünes, N.; Ramalho-Santos, J.; Pedroso De Lima, M.C.. "Fluorescent probes for monitoring virus fusion kinetics: Comparative evaluation of reliability". Biochimica et Biophysica Acta - Biomembranes 1561 1 (2002): 65-75.
    10.1016/S0005-2736(01)00457-6
Capítulo de livro
  1. Aguilar, C.; Mano, M.; Eulalio, A.. "Multifaceted roles of microRNAs in host-bacterial pathogen interaction". In Bacteria and Intracellularity, editado por Pascale Cossart; Craig R. Roy; Philippe Sansonetti, 247-266. Estados Unidos: American Society of Microbiology, 2019.
    Publicado

Propriedade Intelectual

Patente
  1. Eulalio, Ana; Miguel Mano; Serena Zacchigna; Mauro Giacca. 2017. "MicroRNAs for cardiac regeneration through induction of cardiac myocyte proliferation".
    Concedida/Emitida
  2. Luca Braga; Matteo Dal Ferro; Miguel Mano; Eulalio, Ana; Mauro Giacca. 2017. "MicroRNA hsa-miR-665 in cardiac hypertrophy".
    Concedida/Emitida