Ana Diniz (251C-31C4-4A91)

Curriculum Vitae

Ana Diniz

I took my BSc degree in Biochemistry in 2013 and MSc in Biochemistry in 2016 at NOVA University of Lisbon. After my MSc, on a research grant, I was able to finish the work I developed during my Master Thesis, and I was also able to get in contact with new concepts, such as the mechanisms of molecular recognition in glycosciences. In May 2018, I got the opportunity to start a PhD in the PTNMR PhD programme. My research interests are focused on the field of glycosciences and molecular recognition, using NMR as major technique. During the last years, I have contributed to a better understanding of the recognition of glyco-antigens by human lectins, such as Galectin-3 and MGL. Finally, I published 11 original research articles, with a total of 160 citations (h-index 6) and attended 9 national and international conferences, where I was awarded with 2 Best Poster Award. (According to Google Scholar - 07/03/2022)

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Identificação

Identificação pessoal

Nome completo: Ana Diniz
Género: Feminino

Nomes de citação

Diniz, Ana

Identificadores de autor

Ciência ID: 251C-31C4-4A91
ORCID iD: 0000-0003-1698-4668

Endereços de correio eletrónico

a.diniz@campus.fct.unl.pt (Profissional)

Telefones

Telefone

212948300 Ext.: 10954 (Profissional)

Moradas

Lab 302, Departamento de Química, Faculdade de Ciencias e Tecnologia da Universidade Nova de Lisboa, 2829-516, Caparica, Almada, Portugal (Profissional)

Domínios de atuação

Ciências Exatas - Química
Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Português (Idioma materno)

Formação

	Grau	Classificação
2018/05 - 2022/05 Em curso	Doctoral Programme in Nuclear Magnetic Resonance Applied to Chemistry, Materials and Biosciences – PTNMRPhD (PD/00065/2013) (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Structural insights into recognition and signalling of MGL immunomodulatory receptor" (TESE/DISSERTAÇÃO)
2016/05 Concluído	Bioquímica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Carbohydrate-protein interactions under macromolecular crowding" (TESE/DISSERTAÇÃO)	17
2013/12/31 Concluído	Bioquímica (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Purificação e caracterização estrutural da conformação minor do domínio catalítico da enzima PlyG." (TESE/DISSERTAÇÃO)	12

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2018/01 - 2018/05	Investigador (Investigação)	Associação para a Inovação e Desenvolvimento da FCT, Portugal

2016/09 - 2017/12	Investigador (Investigação)	Associação para a Inovação e Desenvolvimento da FCT, Portugal
	REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2017/07/09 - 2017/07/22	Investigador visitante (Investigação)	European Cooperation in Science and Technology, Bélgica
	Medizinische Universität Wien Institut für Pharmakologie, Áustria

Projetos

Bolsa

	Designação	Financiadores
2022 - 2023	NETexplore - Understanding ligand interaction and allosteric modulation of the norepinephrine transporter (NET) EXPL/BIA-BQM/0011/2021 Investigador
2021 - 2022	Targeting human macrophage galactose C-type lectin towards the development of innovative and alternative cancer therapies PTDC/QUI-OUT/2586/2020 Investigador REQUIMTE, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2021/09/30	Advances in MUC1 Glycan Cancer Antigens: From structure to function in the fight against cancer PTDC/BIA-MIB/31028/2017 Investigador REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2020 - 2021	Glycan-human microbiome interaction: glycan diversity and recognition in the human gut with impact on health and nutrition PTDC/BIA-MIB/31730/2017 Investigador REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia
2018 - 2021	Advances into the Glycome: From a structural viewpoint to function in human health and disease IF/00780/2015 Bolseiro de Investigação REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia

Produções

Publicações

Artigo em revista

Mota, Cristiano; Diniz, Ana; Coelho, Catarina; Santos-Silva, Teresa; Esmaeeli, Miriam; Leimkuehler, Silke; Cabrita, Eurico J; Marcelo, Filipa; Romão, Maria João. "Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case". Journal of Medicinal Chemistry 64 17 (2021): 13025-13037. http://dx.doi.org/10.1021/acs.jmedchem.1c01125.
10.1021/acs.jmedchem.1c01125
Gabba, Adele; Bogucka, Agnieszka; Luz, G. John; Diniz, Ana; Coelho, Helena; Corzana, Francisco; Cañada, F. Javier; et al. "Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-type Lectin Bound to GalNAc and the Tumor Associated Tn-Antigen". Biochemistry (2021):
Aceite para publicação
Lima, Carlos D. L.; Coelho, Helena; Gimeno, Ana; Trovão, Filipa; Diniz, Ana; Dias, Jorge S.; Jiménez-Barbero, Jesús; et al. "Structural insights into the molecular recognition mechanism of the cancer and pathogenic epitope, LacdiNAc by immune-related lectins". Chemistry - A European Journal (2021):
Submetido
Lenza MP; Oyenarte I; Diercks T; Quintana JI; Gimeno A; Coelho H; Diniz A; et al. "Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins.". Angewandte Chemie (International ed. in English) (2020): http://europepmc.org/abstract/med/32915505.
10.1002/anie.202011015
de Matos AM; Blázquez-Sánchez MT; Bento-Oliveira A; de Almeida RFM; Nunes R; Lopes PEM; Machuqueiro M; et al. "Glucosylpolyphenols as Inhibitors of Aß-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease.". Journal of medicinal chemistry (2020): http://europepmc.org/abstract/med/32959649.
10.1021/acs.jmedchem.0c00841
Diniz, A.; Coelho, H.; Dias, J.S.; van Vliet, S.J.; Jiménez-Barbero, J.; Corzana, F.; Cabrita, E.J.; Marcelo, F.. "The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin". Chemistry - A European Journal 25 61 (2019): 13945-13955. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074099177&partnerID=MN8TOARS.
10.1002/chem.201902780
Siopa, Filipa; Frade, Raquel F. M.; Diniz, Ana; Andrade, Joana M.; Nicolai, Marisa; Meirinhos, Ana; Lucas, Susana D.; et al. "Acetylcholinesterase Choline-Based Ionic Liquid Inhibitors: In Vitro and in Silico Molecular Docking Studies". ACS Omega 3 12 (2018): 17145-17154. http://dx.doi.org/10.1021/acsomega.8b02347.
10.1021/acsomega.8b02347
de las Rivas, Matilde; Paul Daniel, Earnest James; Coelho, Helena; Lira-Navarrete, Erandi; Raich, Lluis; Compañón, Ismael; Diniz, Ana; et al. "Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4". ACS Central Science 4 9 (2018): 1274-1290. http://dx.doi.org/10.1021/acscentsci.8b00488.
10.1021/acscentsci.8b00488
de las Rivas, M.; Coelho, H.; Diniz, A.; Lira-Navarrete, E.; Compañón, I.; Jiménez-Barbero, J.; Schjoldager, K.T.; et al. "Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts". Chemistry - A European Journal 24 33 (2018): 8382-8392. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048624453&partnerID=MN8TOARS.
10.1002/chem.201800701
de las Rivas, Matilde; Lira-Navarrete, Erandi; Daniel, Earnest James Paul; Compañón, Ismael; Coelho, Helena; Diniz, Ana; Jiménez-Barbero, Jesús; et al. "The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences". Nature Communications 8 1 (2017): http://dx.doi.org/10.1038/s41467-017-02006-0.
10.1038/s41467-017-02006-0
Diniz, A.; Dias, J.S.; Jiménez-Barbero, J.; Marcelo, F.; Cabrita, E.J.. "Protein–Glycan Quinary Interactions in Crowding Environment Unveiled by NMR Spectroscopy". Chemistry - A European Journal 23 53 (2017): 13213-13220. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027513103&partnerID=MN8TOARS.
10.1002/chem.201702800

Poster em conferência

Diniz, Ana; Coelho, Helena; Dias, Jorge S.; Garcia-Martin, Fayna; Westerlind, Ulrika; Cabrita, Eurico J.; Jiménez-Barbero, Jesús; Corzana, F.; Marcelo, Filipa. "Molecular Recognition of MUC1 tumour-associated carbohydrate antigens by human MGL". Trabalho apresentado em 10th GERMN 9th IberoAmerican 7th Iberian NMR meeting, 2021.
Diniz, Ana. "The Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin". Trabalho apresentado em 1st meeting COST ACTION 18132, 2019.
Diniz, Ana. "The Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin". Trabalho apresentado em PTNMR meeting in Porto, 2019.
Diniz, Ana. "The Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin". Trabalho apresentado em NOVA BIOPHYSICA international conference in Lisboa, 2019.
Diniz, Ana. "Molecular Recognition of glycans by lectins of the imune system". Trabalho apresentado em 29th International Carbohydrate Symposium - ICS 2018 Iberian day in Lisboa, 2018.
Diniz, Ana. "Structural basis for human macrophage galactose type lectin recognition". Trabalho apresentado em VIII Ibero-American NMR meeting, 2018.
Diniz, Ana. "Protein-Glycan driven quinary interactions under macromolecular crowding unveiled by NMR". Trabalho apresentado em Advisory Board evaluation in Chemistry Department, FCT-UNL, 2017.
Diniz, Ana. "Mimicking cell-environment: Galectin-3 recognition studies under macromolecular crowding". Trabalho apresentado em 1st Joint French-Portuguese NMR conference/3rd Portuguese RNRMN Meeting/XXVII GERM Conference, 2016.
Diniz, Ana. "Galectin-3 recognition events studied under macromolecular crowding environment". Trabalho apresentado em Integrative Structural Biology tools for the study of protein-ligand interactions Course in Chemistry Department, 2015.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2019/09/21	The Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin	PTNMR meeting (Porto, Portugal)
2018/07/14	Molecular Recognition of glycans by lectins of the imune system	29th International Carbohydrate Symposium - ICS 2018 Iberian day in Lisboa (Lisboa, Portugal)
2017/09/13	Protein-Glycan Quinary Interactions in Crowding Environment Unvieled by NMR Spectroscopy	12ª Reunião do Grupo de Glúcidos – GLUPOR12 in Aveiro (Aveiro, Portugal)

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2019/11 - 2019/11	1st Meeting COST ACTION 18132 (GLYCOnanoPROBES) (2019/11/18 - 2019/11/20) Encontro (Coorganizador)	REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2018 - Atual	Portuguese Society of Chemistry	Member

Tutoria

	Tópico	Nome do aluno
2019/09 - 2020/09	LacdiNAc interaction with lectins	Carlos Lima
2018/09 - 2019/09	MGL molecular recognition	Rui Borralho
2018/01 - 2018/07	Molecular recognition of C-type lectin present in macrophages	Sara Pinheiro
2017/01 - 2017/07	NMR molecular recognition of tumor-associated Thomsen-Friedenreich antigen by tissue lectin Galectin-3	Rui Borralho

Distinções

Prémio

2021	Best Poster Award in the topic of NMR in Health in 10th GERMN 9th Ibero-American 7th Iberiean NMR meeting. Title: Molecular recogntion of MUC1 tumour-asscociated carbohydrate antigens by human MGL.
2019	Best Poster Award in 1st Meeting COST ACTION 18132 (GLYCOnanoPROBES) Title: The Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin
2017	Award Grant for Short Term Scientific Mission (COST Action: CM1306 - 38900

Outra distinção

2018	PhD doctoral fellowship (PD/BD/142847/2018) in the Doctoral Programme in Nuclear Magnetic Resonance Applied to Chemistry, Materials and Biosciences – PTNMRPhD (PD/00065/2013)