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Paula Ludovico graduated in Biology, University of Porto (1994) and did her Master thesis on Molecular Genetics at the University of Minho (1999). In 2002, she concluded her PhD in Biological Sciences at University of Minho. Since 2011, she is an Associate Professor with habilitation at School of Medicine and a Principal Investigator at the Health and Life Sciences Research Institute (ICVS), School of Medicine, University of Minho. Paula was a visiting scientist at the Department of Biological Sciences, Columbia University, New York, USA, at the Department of Neurology, Miami University, Florida, USA and at Institut de Biochimie et Génétique Cellulaires/Centre National de la Recherche Scientifique, Bordeaux, France. In 2013, Paula Ludovico was a Visiting Professor in Faculty of Sciences, Department of Biology at KULeuven, Belgium. Paula Ludovico was from 2019 until 2023 the Pro-director for ICVS. She is member of the Directive board of ICVS since 2014, member of the Scientific Council of ICVS since 2009 and member of the School of Medicine Council since 2023. Paula was a pioneer on the study of regulated cell death in yeast and fungi and has been using yeast as a eukaryotic model to address important scientific questions on cellular and molecular biology. Particularly, she has been exploiting the yeast chronological aging model to address important questions on proteostasis control during cellular aging. More recently, Paula Ludovico has been interested in another age-related disease, the acute myeloid leukemia (AML) and has been involved in many projects on diagnosis, pathogenesis (particularly on the role of autophagy and UPS), treatment and monitoring of AML. Her track record is currently mirrored by 101 publications in international peer-reviewed journals (>8000 citations and h-index=31, Web of Science; January 2024) and 5 book chapters. She has been supported by funding agencies (e.g. FCT) and contracts with the industry (e.g., Amicus therapeutics and Novartis). She serves as an editorial board member for Cancers and Microbial Cell, and she has been an ad-hoc reviewer for more than 70 journals (e.g. Aging Cell, Cell Death and Differentiation, Autophagy and PNAS) and several funding agencies, including the AIAS-COFUND II fellowships 2020, French National Cancer, Biotechnology and Biological Sciences Research Council (UK), National Science Foundation, CAREER Proposals (USA), Research Project Proposal, Research Foundation - Flanders (Belgium) and FCT. Because of her contributions to the field, he has received over 50 invitations to speak/chair at established international meetings.
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Identificação

Identificação pessoal

Nome completo
Paula Cristina da Costa Alves Monteiro Ludovico

Nomes de citação

  • LUDOVICO, PAULA

Identificadores de autor

Ciência ID
221E-F740-BD6C
ORCID iD
0000-0003-4130-7167
Researcher Id
B-4338-2011
Scopus Author Id
6602415839

Endereços de correio eletrónico

  • paulaludovico@gmail.com (Pessoal)

Telefones

Telefone
  • 253604812 (Profissional)

Moradas

  • Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2016
Concluído
 Ciências da Saúde (Título de Agregado)
Universidade do Minho Escola de Medicina, Portugal
2002
Concluído
 Ciências Biológicas (Doutoramento)
Especialização em Sem especialidade
Universidade do Minho Escola de Ciências, Portugal
"Endogenous Programmed Cell Deadth of Saccharomyces Cerevisiae" (TESE/DISSERTAÇÃO)
1998
Concluído
 Genética Molecular Microbiana (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
1994
Concluído
 Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2011 - Atual Professor Associado (Docente Universitário) Universidade do Minho Escola de Medicina, Portugal
2002/10/02 - 2011 Professor Auxiliar (Docente Universitário) Universidade do Minho Escola de Medicina, Portugal
1999 - 2000 Professor Adjunto Convidado (Docente Ensino Superior Politécnico) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Outras Carreiras

Categoria Profissional
Instituição de acolhimento 		Empregador
1994 - 1996 Técnico Superior (Técnico Superior) Centro de Genética Médica Doutor Jacinto Magalhães, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/02 - 2013/08 Professor Visitante Faculty of Sciences, Department of Biology, KULeuven, Bélgica
2004/03 - 2004/07 Cientista Vistiante Department of Neurology, Miami University, Estados Unidos
2000/10 - 2000/12 Cientista Visitante Institut de Biochimie et Génétique Cellulaires/Centre National de la Recherche Scientifique, , França
2000/01 - 2000/08 Cientista Visitante Department of Biological Sciences, Columbia University, Estados Unidos
Projetos

Projeto

Designação Financiadores
2022 - Atual Extracellular Vesicles as Potential Biomarkers inFabrydisease Progression
Amicus_PL_2021
 Amicus Therapeutics Inc
2018 - Atual Innovative Microfluidic Platform for Analysis of myeloidLeukemia blasts
POCI-01-0145-FEDER-030782
Investigador
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018 - Atual Biomimetic microenvironment for the study anddevelopment of targeted therapies in hematologicalmalignancies
POCI-01-0145-FEDER-028159
Investigador
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2025/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
10.54499/LA/P/0050/2020
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/16 - 2021/07/15 Innovative Microfluidic Platform for Analysis of myeloid Leukemia blasts mielóide
PTDC/EMD-EMD/30782/2017
International Iberian Nanotechnology Laboratory, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2016 - 2021 New avenues for the development of personalized medicalinterventions for neurological, oncologic and surgicaldisorders – “PersonalizedNOS
NORTE-01-0145-FEDER-000013
Investigador
Laboratório Associado ICVS 3B's, Portugal
Concluído
2011 - 2014 Study on the relationship between aging and autophagy inyeast Saccharomyces cerevisiae
PTDC/BIA-MIC/114116/2009
Investigador responsável
Laboratório Associado ICVS 3B's, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2013 ZygoSacAR-Mechanistic insights into acetic acid resistancein food spoilage yeasts: from the experimental modelSaccharomyces cerevisiae to Zygosaccharomyces spp.
PTDC/AGR-ALI/102608/2008
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2013 Molecular mechanisms regulating the expression of IL-12cytokines by Mycobacterium tuberculosis infectedmacrophages and dendritic cells.
PTDC/BIABCM/102776/2008
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2013 Unraveling the specific involvement of the small Rho-likeGTPase Cdc42 in the highly polymorphic nature of Paracoccidioides brasiliensis yeast cells
PTDC/BIA-MIC/108309/2008
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 26 - 2011-2012
PEst-C/SAU/LA0026/2011
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010 - 2012 The effects of iron chelation on autophagy and its impact onhaematopoiesis in myelodysplastic syndrome patients
Ludovico
Investigador responsável
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Novartis Farma SA
Concluído
2009 - 2011 NanoMeDiag-Nanobioanalytical platforms for improvedmedical diagnosis of infections caused by pathogenmicroorganisms
NANO/NMed-SD/0076/2007
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2010 Evaluation of the effects of nitrogen supply on yeast cellphysiology, transcriptome, proteome and metabolome foroptimizing the production of economically important odourand flavour compounds.
PTDC/AGR-ALI/71460/2006
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2010 Uncovering pathological mechanism underlying juvenileneuronal ceroid lipofuscinoses: from yeast to more complexmodel systems
PTDC/SAU-NEU/70161/2006
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2005 - 2008 Apoptotic pathway(s) in Saccharomyces cerevisiae: proteomic profile and metacaspase-interactive molecules
POCI/BIA-BCM/57364/2004
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2005 - 2008 A multidisciplinary study of invasive fungal infections inimmunossupressed patients: Host susceptibility to fungiversus fungi resistance to drugs
POCI/SAU-ESP/61080/2004
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2003 - 2006 Cellular and molecular studies in the pathogenic fungi Paracoccidioides brasiliensis: Dimorphism and its regulation by steroid hormones.
POCTI/ESP/45327/2002
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2003 - 2006 Involvement of the sphingolipid signaling in aging and cell death of Saccharomyces cerevisiae - role of sphingomyelinase Isc1p.
POCTI/BCI/45066/2002
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2003 - 2006 Recognition mechanisms of pathogen-associated molecular patterns: Implications in susceptibility to infections relevant to public health.
Proc/60666-MM/734
Investigador
Fundação Calouste Gulbenkian
Concluído
Produções

Publicações

Artigo em conferência
  1. Pirraco, Rogério P.; Azevedo, M. M. G.; Fernandes, Â. M.; Costa, M.; Ludovico, Paula; Reis, R. L.. "The role of autophagy on the differentiation potential of adipose stromal cell sheets under normoxia vs hypoxia". 2015.
    Pirraco R. P., Azevedo M. M. G., Fernandes A., Costa M., Ludovico P., Reis R. L. The role of autophagy on the differentiation potential of adipose stromal cell sheets under normoxia vs hypoxia, Tissue Engineering Part A, Vol. 21, doi:10.1089/ten.tea.2015.
  2. Vieira, Pedro Miguel de Sousa; Marques, Belém Sampaio; Ludovico, Paula; Dias, Alberto Carlos Pires. "Evaluation of the protective effect of Hypericum perforatum phenolics compounds, in the toxicity induced by heterologous expression of a-synuclein". 2011.
  3. Vieira, Pedro Miguel de Sousa; Marques, Belém Sampaio; Ludovico, Paula; Dias, Alberto Carlos Pires. "Hypericum perforatum phenolics compounds: protective role in the toxicity induced by heterologous expression of a-synuclein". 2011.
Artigo em revista
  1. Marco Caligaris; Belém Sampaio-Marques; Riko Hatakeyama; Benjamin Pillet; Paula Ludovico; Claudio De Virgilio; Joris Winderickx; Raffaele Nicastro. "The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses". Journal of Fungi (2023): https://doi.org/10.3390/jof9080787.
    10.3390/jof9080787
  2. Ana Inês Silva; Manuel Direito; Filipa Pinto-Ribeiro; Paula Ludovico; Belém Sampaio-Marques. "Effects of Intermittent Fasting on Regulation of Metabolic Homeostasis: A Systematic Review and Meta-Analysis in Health and Metabolic-Related Disorders". Journal of Clinical Medicine (2023): https://doi.org/10.3390/jcm12113699.
    10.3390/jcm12113699
  3. Esther Clavero; Jose Manuel Sánchez Maldonado; Angelica Macauda; Rob Ter Horst; Sampaio-Marques, B.; Artur Jurczyszyn; Alyssa Clay-Gilmour; et al. "Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/10/8500.
    10.3390/ijms24108500
  4. Alexandra Teixeira; Luís Carreira; Sara Abalde-Cela; Belém Sampaio-Marques; Anabela C. Areias; Paula Ludovico; Lorena Diéguez. "Current and Emerging Techniques for Diagnosis and MRD Detection in AML: A Comprehensive Narrative Review". Cancers (2023): https://doi.org/10.3390/cancers15051362.
    10.3390/cancers15051362
  5. Farida Tripodi; Ermelinda Falletta; Manuela Leri; Cristina Angeloni; Daniela Beghelli; Laura Giusti; Riccardo Milanesi; et al. "Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts". Nutrients (2022): https://doi.org/10.3390/nu14204368.
    10.3390/nu14204368
  6. Fernanda Marques; Luísa Pinto; Maria Manuel Azevedo; Belém Sampaio-Marques; Anabela C. Areias; Ana Salgueira; Manuel Joao Costa; Fernando Rodrigues; Paula Ludovico. "Innovative, integrative, and interactive in-class activity on metabolic regulation: Evaluating educational impacts". Biochemistry and Molecular Biology Education (2021):
    10.1002/bmb.21569
  7. Isabel Castro; Belém Sampaio-Marques; Anabela C. Areias; Hugo Sousa; Ângela Fernandes; José Manuel Sanchez-Maldonado; Cristina Cunha; et al. Autor correspondente: Paula Ludovico. "Functional Genetic Variants in ATG10 Are Associated with Acute Myeloid Leukemia". Cancers 13 6 (2021): 1344-1344. https://doi.org/10.3390/cancers13061344.
    10.3390/cancers13061344
  8. JUAN SAINZ; Francisco José García-Verdejo; Manuel Martinez Bueno; Abhishek Kumar; José Manuel Sánchez-Maldonado; Anna Díez-Villanueva; Ludmila Vodicková; et al. "Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts". Cancers (2021):
    10.3390/cancers13061258
  9. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1". Autophagy 17 1 (2021): 1-382.
    10.1080/15548627.2020.1797280
  10. Magali Humbert; María Morán; Patricia de la Cruz-Ojeda; Jordi Muntané; Tabea Wiedmer; Nadezda Apostolova; Sharon L. McKenna; et al. "Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot". Biology (2020):
    10.3390/biology9030059
  11. Struyfs, Caroline; Cools, Tanne L.; De Cremer, Kaat; Sampaio-Marques, Belem; Ludovico, Paula; Wasko, Brian M.; Kaeberlein, Matt; Cammue, Bruno P. A.; Thevissen, Karin. "The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast". Biochimica et Biophysica Acta (BBA) - Biomembranes (2020): https://publons.com/wos-op/publon/34927135/.
    10.1016/J.BBAMEM.2020.183255
  12. Oliveira-Pinto, Sofia; Pontes, Olivia; Lopes, Diogo; Sampaio-Marques, Belem; Costa, Marta D.; Carvalho, Luisa; Goncalves, Celine S.; et al. "Unravelling the anticancer potential of functionalized chromeno[2,3-b ] pyridines for breast cancer treatment". Bioorganic Chemistry (2020): https://publons.com/wos-op/publon/31453682/.
    10.1016/J.BIOORG.2020.103942
  13. Lemos, Silvia; Sampaio-Marques, Belem; Ludovico, Paula; Gaivao, Isabel; Palmeira, Carlos; Martins, Gabriela; Peixoto, Francisco; Pinto-Leite, Rosario; Oliveira, Paula. "Elucidating the mechanisms of action of parecoxib in the MG-63 osteosarcoma cell line". Anti-Cancer Drugs (2020): https://publons.com/wos-op/publon/33499354/.
    10.1097/CAD.0000000000000901
  14. Isabel Castro; Belém Sampaio-Marques; Paula Ludovico. "Targeting Metabolic Reprogramming in Acute Myeloid Leukemia". Cells 8 9 (2019): 967-967. https://doi.org/10.3390/cells8090967.
    10.3390/cells8090967
  15. Belém Sampaio-Marques; Ana Guedes; Igor Vasilevskiy; Susana Gonçalves; Tiago F. Outeiro; Joris Winderickx; William C. Burhans; Paula Ludovico. Autor correspondente: Paula Ludovico. "a-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1". Aging Cell (2019): e12922-e12922. https://doi.org/10.1111/acel.12922.
    10.1111/acel.12922
  16. Lage, Patricia; Sampaio-Marques, Belem; Ludovico, Paula; Mire, Nuno P.; Mendes-Ferreira, Ana. "Transcriptomic and chemogenomic analyses unveil the essential role of Com2-regulon in response and tolerance of Saccharomyces cerevisiae to stress induced by sulfur dioxide". Microbial Cell (2019): https://publons.com/wos-op/publon/27383013/.
    10.15698/MIC2019.11.697
  17. Silva, Joana Margarida; Rodrigues, Sara; Sampaio-Marques, Belém; Gomes, Patrícia; Neves-Carvalho, Andreia; Dioli, Chrysoula; Soares-Cunha, Carina; et al. "Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology". Cell Death & Differentiation 26 8 (2018): 1411-1427. http://dx.doi.org/10.1038/s41418-018-0217-1.
    10.1038/s41418-018-0217-1
  18. Pontes, Olívia; Costa, Marta; Santos, Filipa; Sampaio-Marques, Belém; Dias, Tatiana; Ludovico, Paula; Baltazar, Fátima; Proença, Fernanda. "Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment". European Journal of Medicinal Chemistry 157 (2018): 101-114. http://dx.doi.org/10.1016/j.ejmech.2018.07.058.
    10.1016/j.ejmech.2018.07.058
  19. Pereira, Olga; Teixeira, Alexandra; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; Ludovico, Paula. "Signalling mechanisms that regulate metabolic profile and autophagy of acute myeloid leukaemia cells". Journal of Cellular and Molecular Medicine 22 10 (2018): 4807-4817. http://dx.doi.org/10.1111/jcmm.13737.
    10.1111/jcmm.13737
  20. Sabrina Büttner; Paula Ludovico; Karin Thevissen. "From Regulated Cell Death to Adaptive Stress Strategies: Convergence and Divergence in Eukaryotic Cells". Oxidative Medicine and Cellular Longevity (2018): https://doi.org/10.1155/2018/2480462.
    10.1155/2018/2480462
  21. Sampaio-Marques, Belém; Ludovico, Paula. Autor correspondente: Ludovico, Paula. "Linking cellular proteostasis to yeast longevity". FEMS Yeast Research 18 5 (2018):
    10.1093/femsyr/foy043
  22. Deprez, Marie-Anne; Eskes, Elja; Wilms, Tobias; Ludovico, Paula; Winderickx, Joris; Ludovico, Paula. "pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity". Microbial Cell 5 3 (2018): 119-136. http://dx.doi.org/10.15698/mic2018.03.618.
    10.15698/mic2018.03.618
  23. Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. "Guidelines and recommendations on yeast cell death nomenclature". Microbial Cell 5 1 (2018): 4-31. http://dx.doi.org/10.15698/mic2018.01.607.
    10.15698/mic2018.01.607
  24. Sampaio-Marques, Belem; Pereira, Helder; Santos, Ana R.; Teixeira, Alexandra; Ludovico, Paula; Sampaio-Marques, Belém; Pereira, Hélder; Ludovico, Ludovico. "Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis". Aging 10 12 (2018): 3821-3833. https://publons.com/wos-op/publon/34927138/.
    10.18632/AGING.101675
  25. Guaragnella, Nicoletta; Stirpe, Mariarita; Burhans, William; Corte-Real, Manuela; Gourlay, Campbell; Ludovico, Paula; Madeo, Frank; et al. "New perspectives from South-Y-East, not all about death A report of the 12th lnternational Meeting on Yeast Apoptosis in Bari, Italy, May 14th-18th, 2017". Microbial Cell 5 2 (2018): 112-115. https://publons.com/wos-op/publon/17246697/.
    10.15698/MIC2018.02.616
  26. Samanfar, Bahram; Shostak, Kristina; Moteshareie, Houman; Hajikarimlou, Maryam; Shaikho, Sarah; Omidi, Katayoun; Hooshyar, Mohsen; et al. "The sensitivity of the yeast, Saccharomyces cerevisiae, to acetic acid is influenced by DOM34 and RPL36A". PeerJ 5 (2017): e4037. http://dx.doi.org/10.7717/peerj.4037.
    10.7717/peerj.4037
  27. Costa, Marina; Cerqueira, Mariana T.; Santos, Tírcia C.; Sampaio-Marques, Belém; Ludovico, Paula; Marques, Alexandra P.; Pirraco, Rogério P.; Reis, Rui L.. "Cell sheet engineering using the stromal vascular fraction of adipose tissue as a vascularization strategy". Acta Biomaterialia 55 (2017): 131-143. http://dx.doi.org/10.1016/j.actbio.2017.03.034.
    10.1016/j.actbio.2017.03.034
  28. Ferreira, A C; Santos, T; Sampaio-Marques, B; Novais, A; Mesquita, S D; Ludovico, P; Bernardino, L; et al. "Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours". Molecular Psychiatry 23 4 (2017): 1031-1039. http://dx.doi.org/10.1038/mp.2017.95.
    10.1038/mp.2017.95
  29. Guedes, Ana; Ludovico, Paula; Sampaio-Marques, Belém. "Caloric restriction alleviates alpha-synuclein toxicity in aged yeast cells by controlling the opposite roles of Tor1 and Sir2 on autophagy". Mechanisms of Ageing and Development 161 (2017): 270-276. http://dx.doi.org/10.1016/j.mad.2016.04.006.
    10.1016/j.mad.2016.04.006
  30. Ludovico, Paula; Côrte-Real, Manuela. "Yeast on the corner of life and death decisions". Mechanisms of Ageing and Development 161 (2017): 199-200. http://dx.doi.org/10.1016/j.mad.2017.02.003.
    10.1016/j.mad.2017.02.003
  31. Vriens, Kim; Kumar, Phalguni Tewari; Struyfs, Caroline; Cools, Tanne L.; Spincemaille, Pieter; Kokalj, Tadej; Sampaio-Marques, Belém; et al. "Increasing the Fungicidal Action of Amphotericin B by Inhibiting the Nitric Oxide-Dependent Tolerance Pathway". Oxidative Medicine and Cellular Longevity 2017 (2017): 1-17. http://dx.doi.org/10.1155/2017/4064628.
    10.1155/2017/4064628
  32. Ludovico, P.; Sampaio-Marques, B.; Osorio, N.; Rodrigues, F.. "The Role of Nitric Oxide Signalling in Yeast Stress Response and Cell Death". Handbook of Microbial Metabolism of Amino Acids (2017): https://publons.com/wos-op/publon/29851327/.
  33. Silva, J.; Rodrigues, S.; Marques, M.; Gomes, P.; Neves-Carvalho, A.; Dioli, C.; Soares-Cunha, C.; et al. "Chronic stress triggers tau pathology through autophagy inhibition and induction of stress granules". Journal of Neurochemistry (2017): https://publons.com/wos-op/publon/17160739/.
    10.1016/S0924-977X(17)31199-9
  34. Guerreiro, Joana; Sampaio-Marques, Belem; Soares, Renata; Coelho, Ana; Leao, Cecilia; Ludovico, Paula; Sa-Correia, Isabel; et al. "Mitochondrial proteomics of the acetic acid - induced programmed cell death response in a highly tolerant Zygosaccharomyces bailii - derived hybrid strain". Microbial Cell 3 2 (2016): 65-78. http://dx.doi.org/10.15698/mic2016.02.477.
    10.15698/mic2016.02.477
  35. Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://dx.doi.org/10.1080/15548627.2015.1100356.
    10.1080/15548627.2015.1100356
  36. Silva, J.; Rodrigues, S.; Marques, M.; Soares-Cunha, C.; Ludovico, P.; Sousa, N.; Sotiropoulos, I.. "The "stressed" autophagy: chronic stress exacerbates Tau pathology by blocking autophagy clearance system". European Neuropsychopharmacology (2016): https://publons.com/wos-op/publon/8617967/.
    10.1016/S0924-977X(16)30924-5
  37. Cruz, Andrea; Ludovico, Paula; Torrado, Egidio; Gama, José Bernardo; Sousa, Jeremy; Gaifem, Joana; Appelberg, Rui; et al. "IL-17A Promotes Intracellular Growth of Mycobacterium by Inhibiting Apoptosis of Infected Macrophages". Frontiers in Immunology 6 (2015): http://dx.doi.org/10.3389/fimmu.2015.00498.
    10.3389/fimmu.2015.00498
  38. Sampaio-Marques, Belém; Ludovico, Paula. "Sirtuins and Proteolytic Systems: Implications for Pathogenesis of Synucleinopathies". Biomolecules 5 2 (2015): 735-757. http://dx.doi.org/10.3390/biom5020735.
    10.3390/biom5020735
  39. Pirraco, R. P.; Azevedo, M. M.; Fernandes, A. M.; Costa, M.; Ludovico, P.; Reis, R. L.. "The Role of Autophagy on the Differentiation Potential of Adipose Stromal Cell Sheets under Normoxia vs Hypoxia". Tissue Engineering Part A (2015): https://publons.com/wos-op/publon/4130725/.
  40. Fernandes, Ângela; Azevedo, Maria M.; Pereira, Olga; Sampaio-Marques, Belém; Paiva, Artur; Correia-Neves, Margarida; Castro, Isabel; Ludovico, Paula. "Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches". Oncotarget 6 31 (2014): 31428-31440. http://dx.doi.org/10.18632/oncotarget.2947.
    10.18632/oncotarget.2947
  41. Gama, José B.; Ohlmeier, Steffen; Martins, Teresa G.; Fraga, Alexandra G.; Sampaio-Marques, Belém; Carvalho, Maria A.; Proença, Fernanda; et al. Autor correspondente: Ludovico, Paula. "Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen". PLoS Neglected Tropical Diseases 8 8 (2014): e3066. http://dx.doi.org/10.1371/journal.pntd.0003066.
    10.1371/journal.pntd.0003066
  42. Barros, Alexandre A.; Rita, Ana; Duarte, C.; Pires, Ricardo A.; Sampaio-Marques, Belém; Ludovico, Paula; Lima, Estevão; Mano, João F.; Reis, Rui L.. "Bioresorbable ureteral stents from natural origin polymers". Journal of Biomedical Materials Research Part B: Applied Biomaterials 103 3 (2014): 608-617. http://dx.doi.org/10.1002/jbm.b.33237.
    10.1002/jbm.b.33237
  43. Sampaio-Marques, Belem; Burhans, William; Ludovico, Paula; Burhans, William C.; Ludovico, Paula. "Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing". Microbial Cell 1 4 (2014): 118-127. http://dx.doi.org/10.15698/mic2014.04.136.
    10.15698/mic2014.04.136
  44. Ludovico, Paula; Burhans, William C.. "Reactive oxygen species, ageing and the hormesis police". FEMS Yeast Research 14 1 (2013): 33-39. http://dx.doi.org/10.1111/1567-1364.12070.
    10.1111/1567-1364.12070
  45. Silva, Alexandra; Sampaio-Marques, Belém; Fernandes, Ângela; Carreto, Laura; Rodrigues, Fernando; Holcik, Martin; Santos, Manuel A. S.; Ludovico, Paula. "Involvement of Yeast HSP90 Isoforms in Response to Stress and Cell Death Induced by Acetic Acid". PLoS ONE 8 8 (2013): e71294. http://dx.doi.org/10.1371/journal.pone.0071294.
    10.1371/journal.pone.0071294
  46. Guaragnella, N; Palermo, V; Burhans, W C; Gourlay, C W; Ludovico, P; Madeo, F; Giannattasio, S; Mazzoni, C. "Yeast between life and death: a summary of the Ninth International Meeting on Yeast Apoptosis in Rome, Italy, 17–20 September 2012". Cell Death & Differentiation 20 9 (2013): 1281-1283. http://dx.doi.org/10.1038/cdd.2013.71.
    10.1038/cdd.2013.71
  47. Weinberger, Martin; Sampaio-Marques, Belém; Ludovico, Paula; Burhans, William C.. "DNA replication stress-induced loss of reproductive capacity inS. cerevisiaeand its inhibition by caloric restriction". Cell Cycle 12 8 (2013): 1189-1200. http://dx.doi.org/10.4161/cc.24232.
    10.4161/cc.24232
  48. Menino, J.F.; Saraiva, M.; Gomes-Rezende, J.; Sturme, M.; Pedrosa, J.; Castro, A.G.; Ludovico, P.; et al. "P. brasiliensis Virulence Is Affected by SconC, the Negative Regulator of Inorganic Sulfur Assimilation". PLoS ONE 8 9 (2013): e74725. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884191896&partnerID=MN8TOARS.
    10.1371/journal.pone.0074725
  49. Mazzoni, Cristina; Giannattasio, Sergio; Winderickx, Joris; Ludovico, Paula. "Yeast Stress, Aging, and Death". Oxidative Medicine and Cellular Longevity 2013 (2013): 1-3. http://dx.doi.org/10.1155/2013/684395.
    10.1155/2013/684395
  50. Sampaio-Marques, Belém; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Márcio; Tenreiro, Sandra; Franssens, Vanessa; Reichert, Andreas S.; et al. Autor correspondente: Ludovico, Paula. "SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy". Autophagy 8 10 (2012): 1494-1509. http://dx.doi.org/10.4161/auto.21275.
    10.4161/auto.21275
  51. Gomes-Rezende, Jéssica A.; Gomes-Alves, Ana G.; Menino, João F.; Coelho, Marco A.; Ludovico, Paula; Gonçalves, Paula; Sturme, Mark H. J.; Rodrigues, Fernando. "Functionality of the Paracoccidioides Mating a-Pheromone-Receptor System". PLoS ONE 7 10 (2012): e47033. http://dx.doi.org/10.1371/journal.pone.0047033.
    10.1371/journal.pone.0047033
  52. Menino, João F.; Osório, Nuno S.; Sturme, Mark H. J.; Barros, Diana; Gomes-Alves, Ana G.; Almeida, Agostinho J.; Ludovico, Paula; et al. "Morphological heterogeneity ofParacoccidioides brasiliensis: relevance of the Rho-like GTPasePbCDC42". Medical Mycology 50 7 (2012): 768-774. http://dx.doi.org/10.3109/13693786.2012.665614.
    10.3109/13693786.2012.665614
  53. Costa-de-Oliveira, Sofia; Sampaio-Marques, Belém; Barbosa, Matilde; Ricardo, Elisabete; Pina-Vaz, Cidália; Ludovico, Paula; Rodrigues, Acácio G.. "An alternative respiratory pathway on Candida krusei: implications on susceptibility profile and oxidative stress". FEMS Yeast Research 12 4 (2012): 423-429. http://dx.doi.org/10.1111/j.1567-1364.2012.00789.x.
    10.1111/j.1567-1364.2012.00789.x
  54. Costa, Vítor; Ludovico, Paula. "Yeast as a platform to uncover ceramide-induced ancient cell death routines". Cell Cycle 11 1 (2012): 14-14. http://dx.doi.org/10.4161/cc.11.1.18730.
    10.4161/cc.11.1.18730
  55. Rodrigues, F.; Sousa, M.J.; Ludovico, P.; Santos, H.; Côrte-Real, M.; Leão, C.. "The Fate of Acetic Acid during Glucose Co-Metabolism by the Spoilage Yeast Zygosaccharomyces bailii". PLoS ONE 7 12 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84871689348&partnerID=MN8TOARS.
    10.1371/journal.pone.0052402
  56. Ludovico, Paula; Osiewacz, Heinz D.; Costa, Vitor; Burhans, William C.. "Cellular Models of Aging". Oxidative Medicine and Cellular Longevity 2012 (2012): 1-3. http://dx.doi.org/10.1155/2012/616128.
    10.1155/2012/616128
  57. Silva, A.; Almeida, B.; Sampaio-Marques, B.; Reis, M.I.R.; Ohlmeier, S.; Rodrigues, F.; Vale, A. do; Ludovico, P.. "Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a specific substrate of yeast metacaspase". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813 12 (2011): 2044-2049. http://dx.doi.org/10.1016/j.bbamcr.2011.09.010.
    10.1016/j.bbamcr.2011.09.010
  58. Carvalho, Agostinho; Osório, Nuno S.; Saraiva, Margarida; Cunha, Cristina; Almeida, Agostinho J.; Teixeira-Coelho, Maria; Ludovico, Paula; et al. "The C Allele of rs5743836 Polymorphism in the Human TLR9 Promoter Links IL-6 and TLR9 Up-Regulation and Confers Increased B-Cell Proliferation". PLoS ONE 6 11 (2011): e28256. http://dx.doi.org/10.1371/journal.pone.0028256.
    10.1371/journal.pone.0028256
  59. Sampaio-Marques, Belém; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Fernando; Ludovico, Paula. "Yeast chronological lifespan and proteotoxic stress: is autophagy good or bad?". Biochemical Society Transactions 39 5 (2011): 1466-1470. http://dx.doi.org/10.1042/bst0391466.
    10.1042/bst0391466
  60. Carvalho, A; Cunha, C; Almeida, A J; Osório, N S; Saraiva, M; Teixeira-Coelho, M; Pedreiro, S; et al. "The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma". Genes & Immunity 13 2 (2011): 197-201. http://dx.doi.org/10.1038/gene.2011.59.
    10.1038/gene.2011.59
  61. Costa-Ramos, Carolina; Vale, Ana do; Ludovico, Paula; dos Santos, Nuno M.S.; Silva, Manuel T.. "The bacterial exotoxin AIP56 induces fish macrophage and neutrophil apoptosis using mechanisms of the extrinsic and intrinsic pathways". Fish & Shellfish Immunology 30 1 (2011): 173-181. http://dx.doi.org/10.1016/j.fsi.2010.10.007.
    10.1016/j.fsi.2010.10.007
  62. Mendes-Ferreira, Ana; Sampaio-Marques, Bele´m; Barbosa, Catarina; Rodrigues, Fernando; Costa, Vi´tor; Mendes-Faia, Arlete; Ludovico, Paula; Lea~o, Ceci´lia. "Accumulation of Non-Superoxide Anion Reactive Oxygen Species Mediates Nitrogen-Limited Alcoholic Fermentation by Saccharomyces cerevisiae". Applied and Environmental Microbiology 76 24 (2010): 7918-7924. http://dx.doi.org/10.1128/aem.01535-10.
    10.1128/aem.01535-10
  63. Weinberger M; Mesquita A; Caroll T; Marks L; Yang H; Zhang Z; Ludovico P; et al. "Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence.". Aging 2 10 (2010): 709-726. http://europepmc.org/abstract/med/21076178.
    10.18632/aging.100215
  64. Mesquita, Ana; Weinberger, Martin; Silva, Alexandra; Sampaio-Marques, Belém; Almeida, Bruno; Leão, Cecília; Costa, Vítor; et al. Autor correspondente: Ludovico, Paula. "Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H 2 O 2 and superoxide dismutase activity". Proceedings of the National Academy of Sciences 107 34 (2010): 15123-15128. http://dx.doi.org/10.1073/pnas.1004432107.
    10.1073/pnas.1004432107
  65. Ludovico, Paula. "Overeating yeast display fatty acid-induced necrotic cell death". Cell Cycle 9 15 (2010): 2945-2953. http://dx.doi.org/10.4161/cc.9.15.12630.
    10.4161/cc.9.15.12630
  66. Dinamarco, T.M.; Figueiredo Pimentel, B.D.C.; Savoldi, M.; Malavazi, I.; Soriani, F.M.; Uyemura, S.A.; Ludovico, P.; Goldman, M.H.S.; Goldman, G.H.. "The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance". Fungal Genetics and Biology 47 12 (2010): 1055-1069. http://www.scopus.com/inward/record.url?eid=2-s2.0-78449236025&partnerID=MN8TOARS.
    10.1016/j.fgb.2010.07.006
  67. Greenwood, M.T.; Ludovico, P.. "Expressing and functional analysis of mammalian apoptotic regulators in yeast". Cell Death and Differentiation 17 5 (2010): 737-745. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950854718&partnerID=MN8TOARS.
    10.1038/cdd.2009.177
  68. Azevedo, M.-M.; Almeida, B.; Ludovico, P.; Cássio, F.. "Metal stress induces programmed cell death in aquatic fungi". Aquatic Toxicology 92 4 (2009): 264-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349193571&partnerID=MN8TOARS.
    10.1016/j.aquatox.2009.02.010
  69. Almeida, B.; Ohlmeier, S.; Almeida, A.J.; Madeo, F.; Leão, C.; Rodrigues, F.; Ludovico, P.. "Yeast protein expression profile during acetic acid-induced apoptosis indicates causal involvement of the TOR pathway". Proteomics 9 3 (2009): 720-732. http://www.scopus.com/inward/record.url?eid=2-s2.0-60549114895&partnerID=MN8TOARS.
    10.1002/pmic.200700816
  70. Almeida, A.J.; Cunha, C.; Carmona, J.A.; Sampaio-Marques, B.; Carvalho, A.; Malavazi, I.; Steensma, H.Y.; et al. "Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis". Fungal Genetics and Biology 46 12 (2009): 919-926. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350408790&partnerID=MN8TOARS.
    10.1016/j.fgb.2009.08.004
  71. Osorio, N. S.; Sampaio-Marques, B.; Chan, C. -H.; Oliveira, P.; Pearce, D. A.; Sousa, N.; Rodrigues, F.. "Neurodevelopmental delay in the Cln3(Delta ex7/8) mouse model for Batten disease". Genes, Brain and Behavior (2009): https://publons.com/wos-op/publon/4772801/.
    10.1111/J.1601-183X.2009.00478.X
  72. Costa, Manuel Joao; Goncalves, Leonor; Ludovico, Paula; Oliveira, Mario; Rodrigues, Fernando; Sousa, Joao Carlos. "Mismatches between the conceptual level of tests and faculty beliefs". The FASEB Journal (2009): https://publons.com/wos-op/publon/29409458/.
  73. Almeida, T.; Marques, M.; Mojzita, D.; Amorim, M.A.; Silva, R.D.; Almeida, B.; Rodrigues, P.; et al. "Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis". Molecular Biology of the Cell 19 3 (2008): 865-876. http://www.scopus.com/inward/record.url?eid=2-s2.0-41649101223&partnerID=MN8TOARS.
    10.1091/mbc.E07-06-0604
  74. Thevissen, K.; Madeo, F.; Ludovico, P.; Cammue, B.; Winderickx, J.. "Joined in death: Highlights of the sixth international meeting on Yeast Apoptosis in Leuven, Belgium, 30 April-4 May 2008". Yeast 25 12 (2008): 927-934. http://www.scopus.com/inward/record.url?eid=2-s2.0-59549090576&partnerID=MN8TOARS.
    10.1002/yea.1640
  75. Almeida, B.; Silva, A.; Mesquita, A.; Sampaio-Marques, B.; Rodrigues, F.; Ludovico, P.. "Drug-induced apoptosis in yeast". Biochimica et Biophysica Acta - Molecular Cell Research 1783 7 (2008): 1436-1448. http://www.scopus.com/inward/record.url?eid=2-s2.0-46549088859&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2008.01.005
  76. ALMEIDA, AJ; CUNHA, C; MARQUES, B; CARMONA, JA; CARVALHO, A; LOGARINHO, E; LEAO, C; et al. "Singular yeast cell morphology of Paracoccidioides brasiliensis is associated to virulence: down-regulation of the CDC42 homolog". The FEBS Journal (2008): https://publons.com/wos-op/publon/1501567/.
  77. Osorio, N. S.; Sampaio-Marques, B.; Pearce, D. A.; Oliveira, R.; Laranjinha, J.; Sousa, N.; Rodrigues, F.. "Studying the role of nitric oxide in the pathological mechanism of Batten disease". The FEBS Journal (2008): https://publons.com/wos-op/publon/6397350/.
  78. Almeida, Bruno; Sampaio-Marques, Belém; Carvalho, Joana; Silva, Manuel T.; Leão, Cecília; Rodrigues, Fernando; Ludovico, Paula; et al. "An atypical active cell death process underlies the fungicidal activity of ciclopirox olamine against the yeastSaccharomyces cerevisiae". FEMS Yeast Research 7 3 (2007): 404-412. http://dx.doi.org/10.1111/j.1567-1364.2006.00188.x.
    10.1111/j.1567-1364.2006.00188.x
  79. Almeida, A.J.; Matute, D.R.; Carmona, J.A.; Martins, M.; Torres, I.; McEwen, J.G.; Restrepo, A.; et al. "Genome size and ploidy of Paracoccidioides brasiliensis reveals a haploid DNA content: Flow cytometry and GP43 sequence analysis". Fungal Genetics and Biology 44 1 (2007): 25-31. http://dx.doi.org/10.1016/j.fgb.2006.06.003.
    10.1016/j.fgb.2006.06.003
  80. Gomes, P.; Sampaio-Marques, B.; Ludovico, P.; Rodrigues, F.; Leão, C.. "Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span". Mechanisms of Ageing and Development 128 5-6 (2007): 383-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-34347385392&partnerID=MN8TOARS.
    10.1016/j.mad.2007.04.003
  81. Almeida, A.J.; Carmona, J.A.; Cunha, C.; Carvalho, A.; Rappleye, C.A.; Goldman, W.E.; Hooykaas, P.J.; et al. "Towards a molecular genetic system for the pathogenic fungus Paracoccidioides brasiliensis". Fungal Genetics and Biology 44 12 (2007): 1387-1398. http://www.scopus.com/inward/record.url?eid=2-s2.0-35748954903&partnerID=MN8TOARS.
    10.1016/j.fgb.2007.04.004
  82. Osório, N.S.; Carvalho, A.; Almeida, A.J.; Padilla-Lopez, S.; Leão, C.; Laranjinha, J.; Ludovico, P.; Pearce, D.A.; Rodrigues, F.. "Nitric oxide signaling is disrupted in the yeast model for Batten disease". Molecular Biology of the Cell 18 7 (2007): 2755-2767. http://www.scopus.com/inward/record.url?eid=2-s2.0-34347398122&partnerID=MN8TOARS.
    10.1091/mbc.E06-11-1053
  83. Carvalho, A.; Costa-De-Oliveira, S.; Martins, M.L.; Pina-Vaz, C.; Rodrigues, A.G.; Ludovico, P.; Rodrigues, F.. "Multiplex PCR identification of eight clinically relevant Candida species". Medical Mycology 45 7 (2007): 619-627. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549082029&partnerID=MN8TOARS.
    10.1080/13693780701501787
  84. Almeida, B.; Buttner, S.; Ohlmeier, S.; Silva, A.; Mesquita, A.; Sampaio-Marques, B.; Osório, N.S.; et al. "NO-mediated apoptosis in yeast". Journal of Cell Science 120 18 (2007): 3279-3288. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548961293&partnerID=MN8TOARS.
    10.1242/jcs.010926
  85. Valdigem, G.L.; Pereira, T.; Macedo, C.; Duarte, M.L.; Oliveira, P.; Ludovico, P.; Sousa-Basto, A.; Leão, C.; Rodrigues, F.. "A twenty-year survey of dermatophytoses in Braga, Portugal". International Journal of Dermatology 45 7 (2006): 822-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745630952&partnerID=MN8TOARS.
    10.1111/j.1365-4632.2006.02886.x
  86. Almeida, T.; Marques, M.; Mojzita, D.; Osorio, H.; Rodrigues, P.; Amorim, M. A.; Ludovico, P.; et al. "Role of Isc1p in oxidative stress resistance and ageing in yeast". Chemistry and Physics of Lipids (2006): https://publons.com/wos-op/publon/4858097/.
  87. Silva, R.D.; Sotoca, R.; Johansson, B.; Ludovico, P.; Sansonetty, F.; Silva, M.T.; Peinado, J.M.; Côrte-Real, M.. "Hyperosmotic stress induces metacaspase- and mitochondria-dependent apoptosis in Saccharomyces cerevisiae". Molecular Microbiology 58 3 (2005): 824-834. http://www.scopus.com/inward/record.url?eid=2-s2.0-27444438569&partnerID=MN8TOARS.
    10.1111/j.1365-2958.2005.04868.x
  88. Ludovico, P.; Madeo, F.; Silva, M.T.. "Yeast programmed cell death: An intricate puzzle". IUBMB Life 57 3 (2005): 129-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-18844400043&partnerID=MN8TOARS.
    10.1080/15216540500090553
  89. Wissing, Silke; Ludovico, Paula; Herker, Eva; Bu¨ttner, Sabrina; Engelhardt, Silvia M.; Decker, Thorsten; Link, Alexander; et al. "An AIF orthologue regulates apoptosis in yeast". Journal of Cell Biology 166 7 (2004): 969-974.
    10.1083/jcb.200404138
  90. "Saccharomyces cerevisiae commits to programmed cell death in response to hyperosmotic stress caused by glucose". Cytometry Part A (2004): https://publons.com/wos-op/publon/7010590/.
  91. VEIGA, A; ARRABACA, J; SANSONETTY, F; Ludovico, P; CORTEREAL, M; LOUREIRODIAS, M; Veiga, A.; et al. "Energy conversion coupled to cyanide-resistant respiration in the yeasts and". FEMS Yeast Research 3 2 (2003): 141-148. http://dx.doi.org/10.1016/s1567-1356(02)00189-7.
    10.1016/s1567-1356(02)00189-7
  92. Ludovico, P; SANSONETTY, F; SILVA, M; CORTEREAL, M. "Acetic acid induces a programmed cell death process in the food spoilage yeast". FEMS Yeast Research 3 1 (2003): 91-96. http://dx.doi.org/10.1016/s1567-1356(02)00166-6.
    10.1016/s1567-1356(02)00166-6
  93. Rodrigues, Fernando; Ludovico, Paula; Sousa, Maria Joa~o; Steensma, H. Yde; Co^rte-Real, Manuela; Lea~o, Ceci´lia. "The Spoilage Yeast Zygosaccharomyces bailii Forms Mitotic Spores: a Screening Method for Haploidization". Applied and Environmental Microbiology 69 1 (2003): 649-653. http://dx.doi.org/10.1128/aem.69.1.649-653.2003.
    10.1128/aem.69.1.649-653.2003
  94. Almeida, T; Marques, M; Amorim, MA; Ludovico, P; Moradas-Ferreira, P; Corte-Real, M; Costa, V. "Sphingolipid signalling in stress resistance and chronological life-span in Saccharomyces cerevisiae: the role of Isc1p". Yeast (2003): https://publons.com/wos-op/publon/7010589/.
  95. Ludovico, P.; Sansonetty, F.; Silva, M.T.; Côrte-Real, M.. "Acetic acid induces a programmed cell death process in the food spoilage yeast Zygosaccharomyces bailii". FEMS Yeast Research 3 1 (2003): 91-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-12244274385&partnerID=MN8TOARS.
    10.1016/S1567-1356(02)00166-6
  96. Rodrigues, F.; Ludovico, P.; Sousa, M.J.; Steensma, H.Y.; Côrte-Real, M.; Leão, C.. "The spoilage yeast Zygosaccharomyces bailii forms mitotic spores: A screening method for haploidization". Applied and Environmental Microbiology 69 1 (2003): 649-653. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347927254&partnerID=MN8TOARS.
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  97. "Acetic acid induces a programmed cell death process in the food spoilage yeast Zygosaccharomyces badii (vol 2, pg 91, 2003)". FEMS Yeast Research (2003): https://publons.com/wos-op/publon/7010594/.
    10.1016/S1567-1356(03)00107-7
  98. Ludovico, Paula; Rodrigues, Fernando; Almeida, Agostinho; Silva, Manuel T.; Barrientos, Antoni; Côrte-Real, Manuela. "CytochromecRelease and Mitochondria Involvement in Programmed Cell Death Induced by Acetic Acid inSaccharomyces cerevisiae". Molecular Biology of the Cell 13 8 (2002): 2598-2606. http://dx.doi.org/10.1091/mbc.e01-12-0161.
    10.1091/mbc.e01-12-0161
  99. "Programmed cell death in Saccharomyces cerevisiae induced by acetic acid.". Yeast (2001): https://publons.com/wos-op/publon/7010593/.
  100. Ludovico, P; Sousa, MJ; Silva, MT; Leao, C; Corte-Real, M; Ludovico, P.; Sousa, M.J.; et al. "Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid". Microbiology 147 9 (2001): 2409-2415. https://publons.com/wos-op/publon/3193432/.
    10.1099/00221287-147-9-2409
  101. Ludovico P; Sansonetty F; Côrte-Real M. "Assessment of mitochondrial membrane potential in yeast cell populations by flow cytometry". Microbiology (2001): https://publons.com/wos-op/publon/3193426/.
    10.1099/00221287-147-12-3335
Capítulo de livro
  1. Mesquita, Inês; Moreira, Diana; Sampaio-Marques, Belém; Laforge, Mireille; Cordeiro-da-Silva, Anabela; Ludovico, Paula; Estaquier, Jérôme; et al. "AMPK in Pathogens". In AMP-activated Protein Kinase, 287-323. Portugal: Springer International Publishing, 2016.
    10.1007/978-3-319-43589-3_12
  2. Winderickx, J.; Ludovico, P.. "Microbial programmed necrosis: The cost of conflicts between stress and metabolism". 2014.
    10.1007/978-1-4614-8220-8_14
  3. Rodrigues, Fernando; Ludovico, Paula; Leão, Cecília. "Sugar Metabolism in Yeasts: an Overview of Aerobic and Anaerobic Glucose Catabolism". In Biodiversity and Ecophysiology of Yeasts, 101-121. Portugal: Springer-Verlag, 2006.
    10.1007/3-540-30985-3_6
Poster em conferência
  1. Dourado, Sara; Conceição Gonçalves; Beatriz Ferreira; Maxime Gomez; Belém Sampaio-Marques; Joris Winderickx; LUDOVICO, PAULA. "The action of the sweeteners cyclamate and saccharin on the chronological aging of Saccharomyces cerevisiae". Trabalho apresentado em Congress of Microbiology and Biotechnology 2023, 2023.
  2. Machado-Costa, D. ; Faria, Ana; Silva, Helena G.; Winderickx, Joris; Al-khlifeh, Enas; LUDOVICO, PAULA. "Analysis of autophagy in different organs of mice subjected to different diets". Trabalho apresentado em EMBO Workshop - Proteostasis: From translation to degradation, 2023.
  3. Machado-Costa, D. ; Faria, Ana; Silva, Helena G.; Winderickx, Joris; Al-khlifeh, Enas; LUDOVICO, PAULA. Autor correspondente: LUDOVICO, PAULA. "Analysis of Autophagy Pattern in Mice under Different Dietary Regimens". Trabalho apresentado em IV INTERNATIONAL MEETING OF THE PORTUGUESE SOCIETY OF GENETICS, 2023.
  4. Teixeira, Alexandra; Sousa-Silva, Maria; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, Belém; et al. "Detecção não invasiva de doença residual mínima em leucemia mielóide aguda usando um sistema de microfluídica para o isolamento e concentração de blastos leucémicos em sangue periférico ou em médula óssea". Trabalho apresentado em 3º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2021.
  5. Teixeira, Alexandra; Sousa-Silva, Maria; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, Belém; et al. "Isolation and concentration of acute myeloid leukemia blasts in measurable residual disease using a microfluidic system". Trabalho apresentado em NanoPT2021 (online), 2021.
  6. Teixeira, Alexandra; Sousa-Silva, Maria; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, Belém; et al. "Isolation of Acute Myeloid Leukemia Blasts Using a Microfluidic System for Accurate Assessment of Minimal Residual Disease". Trabalho apresentado em EuroNanoForum (online), 2021.
  7. Teixeira, Alexandra; Sousa-Silva, Maria; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, Belém; et al. "Microfluidics Platform for the Detection of Minimal Residual Disease in Acute Myeloid Leukemia". Trabalho apresentado em 4th PortASAP Meeting, 2021.
  8. Teixeira, Alexandra; Abalde-Cela, Sara; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, Belém; LUDOVICO, PAULA; Dieguez, Lorena. "Desenvolvimento de uma Plataforma de Microfuídica para Diagnóstico e Monitorização de Doença Residual Mínima em Leucemia Mielóide Aguda". Trabalho apresentado em Encontro Nacional de Jovens Investigadores em Oncologia, 2020.
  9. Teixeira, Alexandra; Abalde-Cela, Sara; Chícharo, Alexandre; Oliveira, Kevin; Carneiro, Adriana; Piairo, Paulina; Sampaio-Marques, B; LUDOVICO, PAULA; Diéguez, Lorena. "Desenvolvimento de uma plataforma de microfluídica para diagnóstico e monitorização de doença residual mínima em leucemia mielóide aguda". Trabalho apresentado em 2º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2020.
  10. Silva, Helena; Castro, Isabel; Sousa, Rafael; Sousa, Hugo; Sampaio-Marques, Belém; LUDOVICO, PAULA. "INTEGRATION OF LIPID METABOLISM WITH KREBS CYCLE IN ACUTE MYELOID LEUKEMIA§". Trabalho apresentado em ISCAM, 2019.
  11. Sousa, Hugo; Sampaio-Marques, Belém; Fernandes , Angela; Castro, Isabel; Sanz-Perez, Juan; LUDOVICO, PAULA. "CLINICAL IMPLICATIONS OF THE AUTOPHAGY CORE GENE VARIATIONS IN ACUTE MYELOID LEUKEMIA". Trabalho apresentado em ISCAM 2019, 2019.
  12. Teixeira, Alexandra; Oliveira, Kevin; Abalde-Cela, Sara; Sampaio-Marques, Belém; LUDOVICO, PAULA; Diéguez, Lorena. "A microfluidics platform for the SERS-based detection of acute myeloid leukemia". Trabalho apresentado em NanoMed Europe (NME), 2019.
  13. Pereira, Hélder; Teixeira, Alexandra; Sampaio-Marques, Belém; LUDOVICO, PAULA. "Messenger molecules modulating yeast chronological aging". Trabalho apresentado em International Meeting on Yeast Ageing and apoptosis (IMYA), 2018.
  14. Teixeira, Alexandra; Pereira, Olga; Fernandes, Sara; Sampaio-Marques, Belém; Castro, Isabel; LUDOVICO, PAULA. "Interplay between glutaminolysis and autophagy in acute myeloid leukemia cells". Trabalho apresentado em 1st Meeting on Vesicular Biology, 2018.
  15. Pereira, Olga; Teixeira, Alexandra; Fernandes, Sara; Mesquita, Ângela; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Interplay between energetic metabolism and autophagic regulation in acute myeloid leukemia cells". Trabalho apresentado em 1st Meeting on Vesicular Biology, 2018.
  16. Teixeira, Alexandra; Pereira, Olga; Mesquita, Ângela; Fernandes, Sara; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Glutaminolysis and autophagy interplay in acute myeloid leukemia cells". Trabalho apresentado em ESH 4th International Conference on Acute Myeloid Leukemia ¿Molecular and Translational¿: Advances in Biology and Treatment, 2017.
  17. Pereira, Olga; Fernandes, Sara; Teixeira, Alexandra; Mesquita, Ângela; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Metabolic cell signalling pathways and autophagy regulation in acute myeloid leukemia cells". Trabalho apresentado em ESH 4th International Conference on Acute Myeloid Leukemia ¿Molecular and Translational¿: Advances in Biology and Treatment, 2017.
  18. Fernandes, Sara; Pereira, Olga; Teixeira, Alexandra; Mesquita, Ângela; Fernandes, Ângela; Sampaio-Marques, Belém; Castro, Isabel; et al. "Cell signaling pathways and autophagy regulation in acute myeloid leukemia". Trabalho apresentado em SINAL 2017 - 8th Meeting on Signal Transduction., 2017.
  19. Pereira, Olga; Teixeira, Alexandra; Fernandes, Sara; Mesquita, Ângela; Sampaio-Marques, Belém; Castro, Isabel; Girão, Henrique; LUDOVICO, PAULA. "Energy metabolism in acute myeloid leukemia cells". Trabalho apresentado em SINAL 2017 - 8th Meeting on Signal Transduction., 2017.
  20. Almeida, Bruno; Ohlmeier S; Gourlay C; Leão C; Madeo F; Rodrigues F; LUDOVICO, PAULA. "Involvement of eEF1A in acetic acid-induced apoptosis in yeast". Trabalho apresentado em 6th IMYA ¿ International Meeting on Yeast Apoptosis, 2008.
  21. Almeida, Teresa; Amorim, Maria Amélia; Almeida, Bruno; Figueiredo, Elisabete; LUDOVICO, PAULA; Moradas-Ferreira, Pedro; Côrte-Real, Manuela; Costa, Vítor. "Role of Lcb5p in oxidative stress resistance and ageing in yeast". Trabalho apresentado em LINK-AGE Meeting and IBMC Symposium ¿The free radical theory of ageing ¿ 50 years and beyond: a tribute to Denham Harman¿, 2007.
  22. Almeida, Teresa; Marques, Marta; Mojzita, Dominik; Rodrigues, Pedro; Amorim, Maria Amélia; LUDOVICO, PAULA; Hohmann, Stefan; et al. "Role of Isc1 in oxidative stress resistance and ageing in yeast". Trabalho apresentado em 47th International Conference on the Bioscience of Lipids, 2006.
  23. Almeida, Teresa; Marques, Marta; Amorim, Maria Amélia; LUDOVICO, PAULA; Moradas-Ferreira, Pedro; Côrte-Real, Manuela; Costa, Vítor. "Yeast neutral sphingomyelinase Isc1p: role in cell death associated with oxidative stress and ageing". Trabalho apresentado em 2nd International Congress on Stress Responses in Biology and Medicine, 2005.
  24. Almeida, Teresa; Marques, Marta; Amorim, Maria Amélia; LUDOVICO, PAULA; Moradas-Ferreira, Pedro; Côrte-Real, Manuela; Costa, Vítor. "The role of the yeast neutral sphingomyelinase Isc1p in cell death associated with oxidative stress and ageing". Trabalho apresentado em 2nd Spanish and Portuguese Congress on Free Radicals, 2004.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/11/17 "Core-autophagy genes as potential prognostic markers in acute myeloid leukaemia EMBO Workshop: Proteostasis: From translation to degradation
(Ericeira, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - Atual The role of cell autonomous and non-autonomous mechanisms during aging: From yeast to long-lived rodent model
Orientador
 Mestrado em Genética Molecular (Mestrado)
Universidade do Minho, Portugal
2020/09/01 - Atual Isolation and characterization of extracellular vesicles from bone marrow of patients with cardiovascular diseases and blood cancer.
Orientador
 Mestrado em Ciências da Saúde (Mestrado)
Universidade do Minho - Escola de Medicina, Portugal
2019/09/30 - Atual Estudo do perfil metabólico em linhas celulares de leucemia mielóide aguda.
Orientador
 Mestrado em Bioquímica Aplicada. (Mestrado)
Universidade do Minho - Escola de Ciências, Portugal
2019/04/01 - Atual Development of microfluidic nanobiosensors for early diagnosis of acute myeloid leukemia and monitoring of minimal residual disease
Coorientador
 Doutoramento em Ciências da Saúde (Doutoramento)
2019/03/04 - Atual Exploiting Metabolic Reprogramming on Acute Myeloid Leukemia Response to Chemotherapy
Orientador
 Mestrado Integrado em Medicina (Mestrado)
Universidade do Minho - Escola de Medicina, Portugal
2018/12/01 - Atual The role of cell signaling during yeast chronological lifespan.
Coorientador
 Doutoramento em Ciências da Saúde. (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2015/03/03 - Atual Leucemia mielóide aguda e diabetes/obesidade: Análise epidemiológica e molecular de fatores de risco/biomarcadores de prognóstico
Orientador
 Doutoramento em Medicina. (Doutoramento)
Universidade do Minho - Escola de Medicina, Portugal
2014/03/15 - Atual Molecular pathogenesis induced by lipidic microbial toxins
Coorientador
 Doutoramento em Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2013/02/13 - Atual The role of LKB1-AMPK pathway on Acute Myeloid Leukemia
Orientador
 PhDoc - Inter-University Doctoral Programme in Ageing and Chronic Disease (Doutoramento)
Universidade do Minho - Escola de Medicina, Portugal
2012/12/06 - Atual The effects of anti-leukemia chemotherapy on LKB1-AMPK pathway functioning in acute myeloid leukemia cell lines
Orientador
 Mestrado em Ciências da Saúde (Mestrado)
Universidade do Minho - Escola de Medicina, Portugal
2012/06/05 - Atual Yeast models of neurodegenerative diseases: Protein misfolding and cell death
Orientador
 Doutoramento em Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2010/11/05 - Atual New insights into caloric restriction-mediated extension of chronological lifespan in Saccharomyces cerevisiae
Orientador
 Doutoramento em Ciências da Saúde (Doutoramento)
Universidade do Minho - Escola de Medicina, Portugal
2010/06/05 - Atual Hypericum perforatum phenolic compounds: protective role in the toxicity induced by heterologous expression of alpha-synuclein and huntingtin in yeast cells
Coorientador
 Mestrado em Biotecnologia e Bioempreendorismo de Plantas Aromáticas e Medicinais (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
2010/04/25 - Atual Targeting autophagy in acute leukaemic cells
Orientador
 Mestrado em Ciências da Saúde (Mestrado)
Universidade do Minho - Escola de Medicina, Portugal
2010/03/04 - Atual Translational regulation of programmed cell death in Saccharomyces cerevisiae, a model in programmed cell death research
Orientador
 Doutoramento em Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2009/11/10 - Atual Polyglutamine diseases (polyQ): construction and characterization of yeast models
Orientador
 Mestrado em Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008/09/01 - Atual The role of yeast aconitase, Aco1p, in oxidative stress-induced apoptosis
Orientador
 mestrado em genética molecular (Mestrado)
Universidade do Minho - Escola de Ciências, Portugal
2006/03/06 - Atual Papel da oxidase alternativa na resistência ao stresse oxidativo em Candida krusei
Orientador
 Mestrado em Microbiologia (Mestrado)
Universidade de Aveiro Departamento de Biologia, Portugal
2005/05/15 - Atual Elucidation of molecular pathways involved in Saccharomyces cerevisiae apoptotic cell death
Orientador
 Doutoramento em Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2003/06/06 - Atual Elucidation of the molecular basis of human mitochondrial neuropathies associated to cytochrome oxidase deficiency: use of Saccharomyces cerevisiae as a model
Orientador
 Mestrado em Genética Molecular (Mestrado)
Universidade do Minho - Escola de Ciências, Portugal
2022/01/01 - 2022/12/07 Exosomes as Potential Biomarkers in Fabry Disease
Orientador
 Master’s Degree in Biomedical Engineering (Mestrado)
Universidade do Minho, Portugal
2016/09/01 - 2020/03/02 Metabolic networks and metabolism in acute myeloid leukemia
Orientador
 Doutoramento em Ciências da Saúde (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2013/09/04 - 2013/09/04 Does hyperglycemia affect acute myeloid leukemia cell survival and chemoresistance? The role of CXCL12 chemoattraction axis
Orientador
 Mestrado em Ciências da Saúde (Outra)
Universidade do Minho - Escola de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/11/07 - 2023/11/07 Workshop on Biochemistry of Ageing 2023 (2023/11/07 - 2023/11/07)
Simpósio (Presidente da Comissão Organizadora)
2022/10/22 - 2022/10/23 Membro da Comissão organizadora do II Encontro de Ciência, Chaves. (2022/10/22 - 2022/10/23)
Encontro (Coorganizador)
2021 - 2021 Virtual Workshop on Biochemistry of Ageing (2021/03/30 - 2021/03/30)
Oficina (workshop) (Coorganizador)
 Sociedade Portuguesa de Bioquímica, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/06/29 - 2022/07/02 Poster presentation. “STUDY OF THE IMPACT OF ATG10 FUNCTIONAL VARIANTS IN ACUTE MYELOID LEUKEMIA”, authors “Sampaio-Marques Belém, Areias Anabela, Castro Isabel, Sousa Hugo, Fernandes Ângela, Sanchez-Maldonado Jose Manuel, Cunha Cristina, Carvalho Agostinho, Sainz Juan, Ludovico Paula” ISCaM2022, Turin, Italy.
Congresso
 International Society for Cancer Metabolism ISCaM2022.
2022/06/29 - 2022/07/02 Poster presentation. “PRESENCE OF MUTATION ON IDH GENES IMPACTS ON THE LIPID METABOLISM OF ACUTE MYELOID LEUKEMIA (AML) CELL LINES”, authors “Sousa Rafael, Ludovico Paula, Sampaio-Marques Belém”. International Society for Cancer Metabolism ISCaM2022, Turin, Italy.
Congresso
 International Society for Cancer Metabolism ISCaM2022, Turin, Italy.
2021 - 2021 Poster presentation: Sampaio-Marques B, Pereira HR, Paiva S andLudovico P. Abrogation of endocytosisblocks the spread of alpha-synuclein inthe yeast model of synucleinopathies. Microbiotec'21, November 2021, Virtualedition.
Congresso
 Microbiotec'21
Sociedade Portuguesa de Microbiologia, Portugal

Sociedade Portuguesa de Biotecnologia, Portugal
2021 - 2021 Poster presentation: . Lameira I, MartinsM, Sampaio-Marques B, Ludovico P andAreias AC. Flow cytometry as a tool tocharacterize an engineered 3D in vitromodel of Acute Myeloid Leukemia. XVIICongress of the Iberian Society ofCytometry, June 2021, Virtual editionIberian
Congresso
 XVII Congress of the Iberian Society of Cytometry
La Sociedad Ibérica de Citometría (SIC), Espanha
2021 - 2021 Poster presentation: Areias AC, Castro I, Sampaio-Marques, Sousa H, Fernandes A, Sanchez-Maldonado JM,Cunha C, Carvalho A, Sainz J andLudovico P. Association of ATG10functional genetic variants in AcuteMyeloid Leukemia. EHA 2021, June 2021,Virtual edition.
Congresso
 EHA2021 Virtual
European Hematology Association, Países Baixos

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/01/10 Júri Provas de Doutoramento em Ciências da Saúde
Vogal
 Samuel Martins Gonçalves (Doutoramento)
Universidade do Minho, Portugal
2023/01/09 Provas de Mestrado em Genética Molecular
Arguente
 Ehsan Omidvar (Mestrado)
Universidade do Minho, Portugal
2022/03/24 Provas de doutoramento em Ciências da Saúde
Vogal
 Ana Margarida Martins Barbosa (Doutoramento)
Universidade do Minho, Portugal
2022/02/01 Ph.D. Course in TECNOLOGIE CONVERGENTI PER I SISTEMI BIOMOLECOLARI (TeCSBi)
Arguente principal
 Riccardo Milanesi (Doutoramento)
Università degli Studi di Milano-Bicocca, Itália
2021/01 Contribution of Aging and Senescence to Intervertebral Disc Degeneration
Vogal
 Emanuel José Magalhães Novais (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2021 Individual performance in cognitive aging and deficit prevention by cognitive training in the rat: integration of structural, molecular and functional correlates
Vogal
 Cristina de F tima Sousa da Mota (Doutoramento)
Universidade do Minho - Escola de Medicina, Portugal
2021 Study of the mode of antifungal activity of currently used antimycotics and plant defensins using single cell analysis
Arguente principal
 Caroline Struyfs (Doutoramento)
Faculty of Bioscience Engineering, KULeuven, Bélgica
2021 The interplay of nutrient signaling, pH homeostasis and inter-organelle communication as key factor for cellular ageing and longevity
Arguente principal
 Marie-Anne Deprez (Doutoramento)
Faculty of Sciences, Department of Biology, KULeuven, Bélgica
2020/04/15 Carbon monoxide against cerebral ischemia: role of mitophagy, mitochondria and cell metabolism
Vogal
 Cláudia Figueiredo Pereira (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 Endocytic trafficking and ubiquitylation of plasma membrane transporters in yeast
Arguente principal
 Gabriel Azevedo Carreira Talaia da Rocha (Doutoramento)
Universidade do Minho, Portugal
2018 Endolysosomal dysfunction and exosome secretion: implications for neurodegenerative disorders
Vogal
 André Miguel Lopes Miranda (Doutoramento)
Universidade do Minho, Portugal
2017 The role of ceramides in the mitochondrial apoptotic pathway induced by acetic acid
Vogal
 António Miguel Araújo Rego (Doutoramento)
Universidade do Minho, Portugal
2016 Mechanistic insights into adaptation and tolerance to acetic acid in Saccharomyces cerevisiae and Zygosaccharomyces bailii
Arguente principal
 Joana Filipa Fernandes Guerreiro (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 Crosstalk between ceramide and cell sgnalling pathways controlling chronological lifespan in yeast
Arguente principal
 Vítor Hugo Freitas Teixeira (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 Intracellular trafficking of AIP56, a bacterial AB toxin targeting NF-kB
Vogal
 Liliana Marisa Gonçalves Pereira (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 Contribution to drug discovery and development for tauopathies using yeast as a model
Vogal
 Marta Isabel Heitor Cerejo (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 The role of autophagy on the response of mice-derived APCs to tropomyosin
Arguente principal
 Tiago Castro Ferraz de Oliveira (Mestrado)
Universidade de Aveiro, Portugal
2015 Mechanisms of action of antifungal agents: Antibiofilm and ion channel inhibitory properties of plant defensins, and single cell analysis of amphotericin B-induced oxidative stress
Arguente principal
 Kim Vriens (Doutoramento)
Katholieke Universiteit Leuven, KU Leuven, Bélgica
2014 The molecular basis of programmed cell death in Neurospora crassa
Arguente principal
 António Pedro da Rocha Cardoso Gonçalves (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2014 Interplay between sphingolipid and nutrient signalling in Niemann-Pick Type C1 disease
Arguente principal
 Rita Pereira Vilaça (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 Elucidation of the role of the DFNA5 protein through the study in yeast and human cell lines
Arguente principal
 Sofie van Rossom (Doutoramento)
Biochemistry and Biotechnology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerpen, Bélgica
2014 Identification and characterization of novel compounds that can alleviate mitochondrial dysfunction using yeast as a model
Arguente principal
 Pieter Spincemaille (Doutoramento)
Faculty of Bioscience Engineering, KULeuven, Bélgica
2013 Deciphering the molecular role of DJ-1 in the etiology of Parkinson’s and Huntington’s disease
Arguente principal
 Maria Leonor Lemos Pereira Miller Fleming (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2013 The effects of anti-leukemia chemotherapy on LKB1-AMPK pathway functioning in acute myeloid leukemia cell lines
Orientador
 Olga Marisa da Silva Pereira (Mestrado)
Universidade do Minho, Portugal
2013 Calcium homeostasis in a yeast model for Parkinson’s disease
Arguente principal
 Liesbeth Faes (Doutoramento)
Faculty of Medicine, Department of Cellular and Molecular Medicine, Kulak, KULeuven, Bélgica
2012 Molecular and genetic characterization of sea bass caspases
Arguente
 Marta Inês Rocha Reis (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 Cellular responses to genome mistranslation
Arguente
 Tatiana Lima de Vilhena Magalhães Costa (Doutoramento)
Universidade de Aveiro, Portugal
2012 The emerging role of autophagy/mitophagy in alpha-synuclein-induced toxicity: studies on the yeast chronological aging model
Orientador
 Maria de Belém de Sousa Sampaio Marques (Doutoramento)
Universidade do Minho, Portugal
2012 New insights into translation during yeast programmed cell death
Orientador
 Maria Alexandra Oliveira da Silva (Doutoramento)
Universidade do Minho, Portugal
2011 New insights into the effects of caloric restriction on Saccharomyces cerevisiae chronological lifespan
Orientador
 Ana Maria Macedo Mesquita (Doutoramento)
Universidade do Minho, Portugal
2011 The role of Isc1p in signal transduction during oxidative stress and chronological aging in yeast
Arguente principal
 António Daniel Cardoso Barbosa (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 Identification of modulators of ataxin-3 proteotoxicity in animal models of Machado-Joseph disease
Vogal
 Andreia Cristiana Teixeira de Castro (Doutoramento)
Universidade do Minho, Portugal
2010 Molecular study of cell degeneration and evolution induced by mRNA mistranslation
Arguente principal
 João Cancela de Amorim Falcão Paredes (Doutoramento)
Universidade de Aveiro, Portugal
2010 Protein glycation and methylglyoxal metabolism in Parkinson’s disease
Arguente principal
 Hugo Miguel Vicente Miranda (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 Uncovering pathological mechanisms underlying Batten disease: from yeast to more complex model systems
Vogal
 Nuno Miguel Sampaio Osório (Doutoramento)
Universidade do Minho, Portugal
2009 Elucidation of molecular pathways involved in Saccharomyces cerevisiae apoptotic cell death
Orientador
 Bruno Miguel Barroso Rodrigues Almeida (Doutoramento)
Universidade do Minho, Portugal
2007 Cellular and molecular studies on the dimorphic pathogenic fungus Paracoccidioides brasiliensis
Vogal
 Agostinho João Ramalho de Almeida (Doutoramento)
Universidade do Minho, Portugal

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2020 - Atual Evaluation of applications for AIAS-COFUND II fellowships 2020
Avaliador
 Aarhus University Aarhus Institute of Advanced Studies, Dinamarca Aarhus University Aarhus Institute of Advanced Studies
2016 - Atual Grant evaluation for the Austrian Science Fund, Austria.
Avaliador
 Fonds zur Förderung der wissenschaftlichen Forschung, Áustria Fonds zur Förderung der wissenschaftlichen Forschung
2015/06/06 - Atual Avaliador do concurso de bolsas de pós-doutoramento, Research Foundation - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen, FWO), Bélgica
Avaliador
 Research Foundation - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen, FWO), Bélgica esearch Foundation - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen, FWO)
2015/01/01 - Atual Co-coordenadora do painel de Biologia Experimental e Bioquímica - BD do Concurso de Bolsas Individuais BD, BDE, BPD, Fundação para a Ciência e Tecnologia (FCT), Portugal.
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2023/01/01 - 2023/12/31 Comissão de Avaliação dos Relatórios Científicos Finais de projetos IC&DT 2019-2022| CA Ciências da Saúde e do Desporto_AP_PTDC/DTP-EPI/6127/2014
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal
2023/01/01 - 2023/12/31 Comissão de Avaliação dos Relatórios Científicos Finais de projetos IC&DT 2019-2022| CA Biologia Experimental e Bioquímica
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal
2019/01/01 - 2023/12/31 Comissão de Avaliação dos Relatórios Científicos Finais de Projetos 2019-2023.
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal
2019/01/01 - 2023/12/31 Comissão de Avaliação dos Relatórios Científicos Finais de Projetos 2019-2023.
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal
2022/09/01 - 2023/01/05 Júri do Concurso com a ref.ª CTTI-PI-68/22-ICVS(1), para recrutamento de 1 (um) lugar de Investigador doutorado equiparado à categoria de Investigador Auxiliar, no âmbito do Concurso de Estímulo ao Emprego Científico – Institucional (referência n.º CEECINST/00018/2021)
Avaliador
 Universidade do Minho Escola de Medicina, Portugal
2022/09/05 - 2022/12/05 Comissão de avaliação para efeitos de renovação da atividade desenvolvida dos doutorados contratados ao abrigo do decreto-lei n.º 57/2016
Avaliador
 Universidade de Coimbra Faculdade de Medicina, Portugal
2021/08 - 2021/09 Evaluator for the 1st step (remote evaluation) of the ex-ante evaluation procedure for proposals submitted under Call Credits & Projects Call 2021 of the Fund for Scientific Research - FNRS.
Avaliador
 Fonds de la Recherche Scientific, Bélgica Fonds de la Recherche Scientific
2021/04 - 2021/05 Eevaluation process of projects received under the call for proposals in “Biological and basic sciences for Cancer research 2021”, opened to all areas of scientific disciplines involved in tumour biology research (biology, chemistry, physics, computing science or mathematics), to promote the development of original, multidisciplinary and competitive projects.
Avaliador
 Institut National du Cancer, França Institut National du Cancer
2019 - 2019 Evaluation Research Grants from Human Frontier Science Program.
Avaliador
 Human Frontier Science Program, França Human Frontier Science Program
2016 - 2016 Grant evaluation for Fondation pour la Recherche Médicale, France.
Avaliador
 Fondation pour la Recherche Médicale, França Fondation pour la Recherche Médicale
2015 - 2015 Evaluation of research Project Proposal, Research Foundation - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen, FWO), Belgium.
Avaliador
 Research Foundation - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen, FWO), Bélgica Research Foundation - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen, FWO)
2015 - 2015 Evaluation of a postdoctoral Fellow, Research Foundation - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen, FWO), Belgium.
Avaliador
 Research Foundation - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen, FWO), Bélgica Research Foundation - Flanders (Fonds Wetenschappelijk Onderzoek - Vlaanderen, FWO)
2012 - 2015 Evaluation of a grant from Research Council of KU Leuven, Belgium.
Avaliador
 Flemish Community’s Special Research Fund (BOF), Bélgica Flemish Community’s Special Research Fund (BOF)
2010 - 2010 Evaluation of a grant from National Science Foundation, CAREER Proposals, USA.
Avaliador
 National Science Foundation, Estados Unidos National Science Foundation

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2023/06/16 - 2023/08/16 Colaboração no processo de avaliação de uma candidatura no âmbito do Concurso de Doutoramento em Ambiente Académico - 2023 Governo dos Açores, Portugal

Fundo Regional para a Ciência e Tecnologia, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023/04/11 - 2023/04/21 Pos Graduation course: CELLFUNCTIONAL ANDPHENOTYPICAL ANALYSIS: theusefulness of flow cytometryand related tools (5th Edition) (Pós-Graduação) Universidade do Minho, Portugal

Laboratório Associado ICVS 3B's, Portugal
2021/04/12 - 2021/04/30 Pos Graduation course: CELLFUNCTIONAL ANDPHENOTYPICAL ANALYSIS: theusefulness of flow cytometryand related tools (4nd Edition) (Postgraduate Certificate) Universidade do Minho Escola de Medicina, Portugal

Laboratório Associado ICVS 3B's, Portugal

Entrevista / Programa (rádio / tv)

Programa Tema
2014 - 2014 "Praça da Alegria" "Maratona da Saúde": Divulgação Institucional do ICVS
2011 - 2011 “Consultório” Entrevista sobre o trabalho que coordenou e publicou na Proc Natl Acad Sci USA em 2010. A entrevista centrou-se na discussão do papel das espécies reativas de oxigénio no processo de envelhecimento celular.

Expedição científica

Descrição da atividade Instituição / Organização
2023/10/17 - 2023/10/31 Participação em atividades de investigação no "Department of Biology", KULeuven Faculty of Sciences, Department of Biology, KULeuven, Bélgica
2022/05/02 - 2022/05/06 ERAMUS+ -Staff Mobility for Training - Ghent University, Belgium Universiteit Gent, Bélgica

Membro de associação

Nome da associação Tipo de participação
2020 - Atual Sociedade Portuguesa de Bioquímica Secretária da Assembleia
2019 - Atual BACIS Center for Health Innovation Secretária da Mesa
2023/01/01 - 2024/12/31 Direção Sociedade Portuguesa de Bioquímica Membro da Direção

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2021/01/01 - 2025/12/31 Comissão de Assessoria para a Gestão de Projetos de Investigação da Universidade do Minho – CAGI-UM
Membro
 Universidade do Minho, Portugal
2021/01/01 - 2023/07/31 Comissão de Curso Mestrado Integrado em Medicina, Escola de Medicina
Membro
 Universidade do Minho, Portugal
2019/01/11 - 2022/12/16 Pró-Diretor, Direção do Instituto de Investigação em Ciências da Vida e Saúde (ICVS)
Outro

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023/09/09 - 2023/12/31 Procedimento concursal de selecção internacional para a contratação de investigador(a) doutorado(a) ao abrigo do regime jurídico do emprego cientifico CTTI-PI-9/23-ICVS(1) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/09/01 - 2023/12/31 Procedimento concursal de seleção internacional para a contratação de investigador(a) doutorado(a) qdo abrigo doe regime jurídico do emprego científico CTTI-PI-13/23-ICVS(1) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/05/01 - 2023/12/31 Membro do Júri do Concurso com a ref.ª CTTI-PI-7/23-ICVS(1), para recrutamento de um Investigador doutorado de nível inicial, no âmbito do projeto intitulado “Host-directed medicine in invasive fungal infections – HDM-FUN” Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/08/30 - 2023/09/30 Avaliação dos relatórios apresentados pelos Investigadores Doutorados contratados ao abrigo do Decreto-Lei n.º 57/2016, de 29 de agosto. Universidade de Coimbra Faculdade de Medicina, Portugal
2023/03/01 - 2023/08/31 Evaluator for the 1st step (remote evaluation) of the ex-ante evaluation procedure for proposals submitted under Call Credits & Projects Call 2023 of the Fund for Scientific Research - FNRS.
2022/03/01 - 2022/08/31 Evaluator for the 1st step (remote evaluation) of the ex-ante evaluation procedure for proposals submitted under Call Credits & Projects Call 2022 of the Fund for Scientific Research - FNRS.

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2021 - 2021 Cells (2073-4409) MDPI
2021 - 2021 Faculty Reviews (2732-432X) Faculty Opinions
2021 - 2021 Human Genetics Springer
2021 - 2021 International Journal of Molecular Sciences (1422-0067) MDPI
2021 - 2021 Cellular Signalling (0898-6568) Elsevier
2021 - 2021 Scientific Reports (2045-2322) Nature
2020/04/01 - 2020/04/20 FEBS Journal (1742-4658) Wiley (Blackwell Publishing)
2020/04/09 - 2020/04/18 Aging (1945-4589)
2020/03/01 - 2020/03/24 Scientific Reports (2045-2322) Springer Science and Business Media LLC
2020/03/01 - 2020/03/19 Current Genetics (1432-0983) Springer-Verlag
2020/02/01 - 2020/02/13 Cancers (2072-6694) MDPI AG
2019/10 - 2019/10 Cancers (2072-6694) MDPI AG
2019/10 - 2019/10 FEMS Yeast Research (1567-1364) Oxford University Press
2019/09 - 2019/10 Scientific Reports (2045-2322) Springer Science and Business Media LLC
2019/08/01 - 2019/08/15 Current Genetics (1432-0983) Springer-Verlag
2019 - 2019 Acta Biochimica et Biophysica Sinica (1745-7270) Oxford University Press
2005 - 2019 Microbiology (1608-3237) Pleiades Publishing
2018 - 2018 Current Medicinal Chemistry (0929-8673) Bentham Science
2010 - 2018 Aging Cell (1474-9728) Wiley (Blackwell Publishing)
2005 - 2018 FEMS Yeast Research (1567-1364) Oxford University Press
2017 - 2017 Frontiers in Oncology (2234-943X) Frontiers Media SA
2017 - 2017 Scientific Reports (2045-2322) Springer Nature
2014 - 2017 Experimental Gerontology (0531-5565) Elsevier
2016 - 2016 Mechanisms of Ageing and Development (0047-6374) Elsevier
2016 - 2016 Methods in Enzymology Elsevier
2016 - 2016 Translation (2169-0731) Landes Bioscience
2014 - 2016 Microbial Cell (2311-2638) Shared Science Publishers OG
2015 - 2015 Applied Microbiology and Biotechnology (1432-0614) Springer-Verlag
2015 - 2015 BioMed Research International (2314-6141) Hindawi Limited
2015 - 2015 Autophagy (1554-8635) Landes Bioscience
2015 - 2015 Biomolecules (2218-273X) MDPI AG
2015 - 2015 PLoS Neglected Tropical Diseases (1935-2735) Public Library of Science
2014 - 2015 Dose-Response (1559-3258) SAGE Publications
2008 - 2015 Molecular Microbiology (1365-2958) Wiley (Blackwell Publishing)
2014 - 2014 Ageing Research Reviews (1568-1637) Elsevier
2014 - 2014 BioEssays (1521-1878) Wiley (John Wiley & Sons)
2014 - 2014 Current Genetics (1432-0983) Springer-Verlag
2014 - 2014 DNA and Cell Biology (1557-7430) Mary Ann Liebert
2014 - 2014 Mitochondrion (1567-7249) Elsevier
2013 - 2013 Molecular Biology of the Cell (1939-4586) American Society for Cell Biology
2012 - 2012 Antimicrobial Agents and Chemotherapy (1098-6596) American Society for Microbiology
2012 - 2012 Current Microbiology (1432-0991) Springer-Verlag
2012 - 2012 General Physiology and Biophysics (1338-4325) "AEPress, s.r.o."
2008 - 2012 PLoS ONE (1932-6203) Public Library of Science
2011 - 2011 Biochemical Society Transactions (1470-8752) Portland Press
2011 - 2011 Expert Opinion on Drug Discovery (1746-045X) Informa UK (Taylor & Francis)
2008 - 2011 FEBS Letters (1873-3468) Wiley (John Wiley & Sons)
2010 - 2010 Fungal Biology (1878-6146) Elsevier
2009 - 2009 APOPTOSIS (1573-675X) Springer-Verlag
2009 - 2009 Cell Death and Differentiation (1350-9047) Springer Nature
2009 - 2009 Journal of Free Radicals in Biology & Medicine (0748-5514) Elsevier
2009 - 2009 PROTOPLASMA (1615-6102) Springer-Verlag
2006 - 2009 Gene (0378-1119) Elsevier
2008 - 2008 Annals of Microbiology (1869-2044) Springer-Verlag
2008 - 2008 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (0167-4889) Elsevier