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Carolin Hoffmann performed her PhD at Maastricht University, where she set-up the research line of autoantibodies in psychotic disorders under supervision of Prof. Pilar Martinez. After receiving her PhD degree in 2018, she continued her research line in Maastricht as a PostDoc. In 2019 she stayed 3 months in the Neuroscience department of Biodonostia (San Sebastian, Spain). She recently received a 6-year fellowship from the Portuguese Foundation for Science and Technology (FCT) to work on the role of complement in schizophrenia. In the end of 2020, she joined the Molecular Neuroscience and Gene Therapy Group at the University of Algarve (Portugal).In February 2022, she received her first funding as principal investigator (10 000 EUR from Algarve Biomedical Center) for reprogramming PBMCs from Schizophrenia patients into iPSCs and establishing neuronal models. She had several gaps in her productivity: 2019: 6 months for her first maternity leave; 2020: 7 months transfer between contracts; 2021: 8 months for her second maternity leave. Nevertheless, she has a competitive output of 14 articles published in peer reviewed journals (H-index 8), one book chapter (co-author), six poster and six oral presentations at international conferences and organization of 5 scientific events.
Identificação

Identificação pessoal

Nome completo
Carolin Hoffmann

Nomes de citação

  • Hoffmann, Carolin

Identificadores de autor

Ciência ID
211F-792C-1B73
ORCID iD
0000-0002-2528-7541

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências da Engenharia e Tecnologias - Engenharia Médica - Tecnologia Laboratorial

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Alemão (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Holandês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2013/08/01 - 2017/10/31
Concluído
School for Mental Health and Neurosciences (Doctor of Philosophy)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos
"The brain under attack: Autoantibodies in psychotic disorders" (TESE/DISSERTAÇÃO)
2011/08/01 - 2013/05/03
Concluído
Medical Sciences (Master)
Especialização em Biomedicine
Karolinska Institutet, Suécia
"Optimizing protein expression and disulfide bond formation in E.Coli" (TESE/DISSERTAÇÃO)
2008/08/01 - 2011/07/01
Concluído
Biomedical Sciences (Bachelor)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos
"Detection of autoantibodies in Schizophrenia" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2020/09/01 - Atual Investigador (Investigação) Universidade do Algarve, Portugal
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2017/11/01 - 2020/04/01 Pós-doutorado (Investigação) Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos
2018/11/01 - 2019/03/01 Pós-doutorado (Investigação) Biodonostia Instituto de Investigación Sanitaria, Espanha
Projetos

Bolsa

Designação Financiadores
2022/08/01 - 2024/12/31 Epigenetic Signatures of Schizophrenia in an iPSC derived model during neuronal differentiation
ABC-RI 2022
Investigador responsável
Universidade do Algarve Algarve Biomedical Center, Portugal
Universidade do Algarve Algarve Biomedical Center
Em curso
2016/05/01 - 2016/07/31 Isolation of human autoantibodies against ion channels and associated proteins
245-2016
Bolseiro de Doutoramento
Scripps Research Institute, Estados Unidos
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH
Concluído

Projeto

Designação Financiadores
2020/09/01 - Atual Deciphering the role of the complement system in schizophrenia
CEECIND/02649/2018
Bolseiro de Iniciação Científica
Universidade do Algarve - Campus de Gambelas, Portugal

Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Associação para a Inovação e Desenvolvimento da FCT
2018/03/01 - 2020/04/01 Immune mechanisms of psychotic disorders
Kootstra_2018
Bolseiro de Pós-Doutoramento
2018/11/01 - 2019/04/01 Interplay of mitochondrial and immune function in neurodegenerative conditions
Investigador Pós-doutorado
2015/08/01 - 2018/10/30 Autoantibodies in psychotic disorders
022005019
Bolseiro de Doutoramento
Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Países Baixos
Concluído
2013/08/01 - 2014/08/01 Establishing antibody detection methods
Kootstra_2014
Bolseiro de Doutoramento
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos
Concluído
Produções

Publicações

Artigo em revista
  1. Zong, Shenghua; Vinke, Anita M.; Du, Peng; Hoffmann, Carolin; Mané-Damas, Marina; Molenaar, Peter C.; Damoiseaux, Jan G. M. C.; et al. "Anti-GAD65 autoantibody levels measured by ELISA and alternative types of immunoassays in relation to neuropsychiatric diseases versus diabetes mellitus type 1". Frontiers in Neurology 14 (2023): http://dx.doi.org/10.3389/fneur.2023.1111063.
    10.3389/fneur.2023.1111063
  2. Vinke, Anita M.; Zong, Shenghua; Janssen, Josien H.; Correia-Hoffmann, Carolin; Mané-Damas, Marina; Damoiseaux, Jan G.M.C.; de Vries, J.M.; et al. "Autoimmune Encephalitis With mGluR1 Antibodies Presenting With Epilepsy, but Without Cerebellar Signs". Neurology - Neuroimmunology Neuroinflammation 9 4 (2022): e1171. http://dx.doi.org/10.1212/nxi.0000000000001171.
    10.1212/nxi.0000000000001171
  3. Hoffmann, Carolin; Zong, Shenghua; Mané-Damas, Marina; Stevens, Jo; Malyavantham, Kishore; Küçükali, Cem Ismail; Tüzün, Erdem; et al. "The search for an autoimmune origin of psychotic disorders: Prevalence of autoantibodies against hippocampus antigens, glutamic acid decarboxylase and nuclear antigens". Schizophrenia Research 228 (2021): 462-471. http://dx.doi.org/10.1016/j.schres.2020.12.038.
    10.1016/j.schres.2020.12.038
  4. Zong, Shenghua; Correia-Hoffmann, Carolin; Mané-Damas, Marina; Kappelmann, Nils; Molenaar, Peter C.; van Grootheest, Gerard; Penninx, Brenda W. J. H.; et al. "Novel neuronal surface autoantibodies in plasma of patients with depression and anxiety". Translational Psychiatry 10 1 (2020): http://dx.doi.org/10.1038/s41398-020-01083-y.
    10.1038/s41398-020-01083-y
  5. Mané-Damas, Marina; Vinke, Anita; Hoffmann, Carolin; Zong, Shenghua; Losen, Mario; Molenaar, Peter C.; Damoiseaux, Jan; et al. "Unidentified Neuronal Surface IgG Autoantibodies in a Case of Hashimoto's Encephalopathy". Frontiers in Immunology 11 (2020): http://dx.doi.org/10.3389/fimmu.2020.01358.
    10.3389/fimmu.2020.01358
  6. Hoffmann, Carolin; Zong, Shenghua; Mané-Damas, Marina; Molenaar, Peter C.; Losen, Mario; Titulaer, Maarten J.; Martinez-Martinez, Pilar. "Absence of Autoantibodies Against Neuronal Surface Antigens in Sera of Patients With Psychotic Disorders". JAMA Psychiatry 77 3 (2020): 322. http://dx.doi.org/10.1001/jamapsychiatry.2019.3679.
    10.1001/jamapsychiatry.2019.3679
  7. Hoffmann C; Stevens J; Zong S; van Kruining D; Saxena A; Küçükali CI; Tüzün E; et al. "Alpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder.". PloS one (2018): http://europepmc.org/abstract/med/30521579.
    10.1371/journal.pone.0208412
  8. Vinke, Anita M.; Schaper, Frédéric L.W.V.J.; Vlooswijk, Mariëlle C.G.; Nicolai, Joost; Majoie, Marian H.J.M.; Martinez Martinez, Pilar; Hoffmann, Carolin; Damoiseaux, Jan G.M.C.; Rouhl, Rob P.W.. "Anti-GAD antibodies in a cohort of neuropsychiatric patients". Epilepsy & Behavior 82 (2018): 25-28. http://dx.doi.org/10.1016/j.yebeh.2018.03.004.
    10.1016/j.yebeh.2018.03.004
  9. Zong, Shenghua; Hoffmann, Carolin; Mané-Damas, Marina; Molenaar, Peter; Losen, Mario; Martinez-Martinez, Pilar. "Neuronal Surface Autoantibodies in Neuropsychiatric Disorders: Are There Implications for Depression?". Frontiers in Immunology 8 (2017): http://dx.doi.org/10.3389/fimmu.2017.00752.
    10.3389/fimmu.2017.00752
  10. Hoffmann, Carolin; Zong, Shenghua; Mané-Damas, Marina; Molenaar, Peter; Losen, Mario; Martinez-Martinez, Pilar. "Autoantibodies in Neuropsychiatric Disorders". Antibodies 5 2 (2016): 9. http://dx.doi.org/10.3390/antib5020009.
    10.3390/antib5020009
  11. de Witte, Lot D.; Hoffmann, Carolin; van Mierlo, Hans C.; Titulaer, Maarten J.; Kahn, René S.; Martinez-Martinez, Pilar. "Absence ofN-Methyl-D-Aspartate Receptor IgG Autoantibodies in Schizophrenia". JAMA Psychiatry 72 7 (2015): 731. http://dx.doi.org/10.1001/jamapsychiatry.2015.0526.
    10.1001/jamapsychiatry.2015.0526
  12. Hoffmann, Carolin; Nogales-Gadea, Gisela; Saxena, Abhishek; Hounjet, Judith; Coenen, Daniëlle; Molenaar, Peter; Losen, Mario; Martinez-Martinez, Pilar. "Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells". Journal of Visualized Experiments 100 (2015): http://dx.doi.org/10.3791/52830.
    10.3791/52830
  13. Martinez-Martinez, P.; Molenaar, P.; Losen, M.; Hoffmann, C.; Stevens, J.; De Witte, L.D.; van Amelvoort, T.; Rutten, B.P.F.; van Os, J.. "Auto-immune disorders as a possible cause of neuropsychiatric syndromes". Tijdschrift voor psychiatrie 57 3 (2015): 183-191. http://www.tijdschriftvoorpsychiatrie.nl/assets/articles/57-2015-3-artikel-martinez.pdf.
    Acesso aberto
  14. Asrican, Brent; Augustine, George J.; Berglund, Ken; Chen, Susu; Chow, Nick; Deisseroth, Karl; Feng, Guoping; et al. "Next-generation transgenic mice for optogenetic analysis of neural circuits". Frontiers in Neural Circuits 7 (2013): http://dx.doi.org/10.3389/fncir.2013.00160.
    10.3389/fncir.2013.00160
  15. Andrade, Pablo; Visser-Vandewalle, Veerle; Hoffmann, Carolin; Steinbusch, Harry W. M.; Daemen, Marc A.; Hoogland, Govert. "Role of TNF-alpha during central sensitization in preclinical studies". Neurological Sciences 32 5 (2011): 757-771. http://dx.doi.org/10.1007/s10072-011-0599-z.
    10.1007/s10072-011-0599-z
Tese / Dissertação
  1. Hoffmann, Carolin. "The Brain under attack: Autoantibodies in psychotic disorders". Doutoramento, Universiteit Maastricht Faculty of Health Medicine and Life Sciences, 2018.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/11/15 Epigenetic regulation of the complement genes in Schizophrenia: In-Situ analysis and ideas for the future. Seminar at the School of Mental Health and Neuroscience (MHeNs) at Maastricht University
School of Mental Health and Neuroscience (Maastricht, Países Baixos)
2018/08/31 Prevalence of neuronal and systemic autoantibodies in sera of patients with psychotic disorders and mental disorders without psychosis 14th International congress on Neuroimmunology
International Society of Neuroimmunology (Brisbane, Austrália)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2023/09/11 - 2024/08/01 Methylation signatures of interferon gamma signaling in human iPSC-derived neurons
Orientador
Ciências Biomédicas (Mestrado)
Universidade do Algarve, Portugal
2024/03/11 - 2024/04/30 Effect of IFN-gamma on neurodevelopment in an iPSC-derived model
Orientador
Medicine (Mestrado)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2023/04/17 - 2023/06/30 Testing the effect of VitaminK on complement system in cell culture systems
Orientador
Ciências Biomédicas
Universidade do Algarve, Portugal
2022/04 - 2023/06 Methylation Changes of Complement Genes during Neuronal Differentiation – a Data Mining Approach
Orientador
Ciências Biomédicas
Universidade do Algarve, Portugal
2017/02/01 - 2017/09/15 Cloning and analyzing IgG antibodies from NMDAR encephalitis and MuSk-Myasthenia Gravis patients Biomedicine (Mestrado)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos
2016/02/01 - 2016/07/31 Detection of Pathogenic Autoantibodies in Schizophrenia
Coorientador
Biomedicine (Mestrado)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos
2015/02/01 - 2015/07/31 The role of the a-7 nicotinic acetylcholine receptor as a target of autoantibodies in schizophrenia
Coorientador
Biomedicine (Mestrado)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos
2015/02/01 - 2015/07/31 Development of a cell-based assay to detect autoantibodies against the alpha-7 subunit of the nicotinic acetylcholine receptor in schizophrenia
Coorientador
Biomedicine (Mestrado)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos
2014/12/01 - 2015/07/31 Identification and cloning of autoantibodies in schizophrenia and encephalitis
Coorientador
Biologie en Medisch Laboratoriumonderzoek Research (Outra)
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos
2014/02/01 - 2014/07/20 Autoantibodies against the N-methyl-D-aspartate receptor in schizophrenia
Coorientador
Biomedical sciences (Mestrado)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2023/09 - Atual "Algarve Biomedical Center Research Institute - Tours" or "ABC-RI Tours" These are bi-weekly (or on request) visits to the research labs. It show-cases the ongoing research, some of our latest findings and gives the opportunity to meet scientists at work. We also tour the UAlgTec Health Simulation Centre with its simulators for a wide range of health cases and scenarios. (2023/09)
Outro (Coorganizador)
Algarve Biomedical Center Research Institute, Portugal
2018/05/01 - 2018/11/28 Member of the organization-committee of the Annual Research Day 2018 of the department of psychiatry and Neuropsychology with the title "Career perspectives in and outside academia" (2018/11/28 - 2018/11/28)
Simpósio (Membro da Comissão Organizadora)
Universiteit Maastricht, Países Baixos
2017/03/01 - 2017/07/31 MHeNs Translational Neuroscience Masterclass “Autoantibodies in neuropsychiatric disorders” organized June 2017 for the PhD students of the school for Mental Health and Neuroscience (Maastricht University) as well as scientists from the Netherlands and surrounding areas. Role: Co-organization, oral presentation, discussion leader and moderator: guide a group discussion on different research questions (2017/07/14 - 2017/07/14)
Simpósio (Coorganizador)
Universiteit Maastricht, Países Baixos
2017/02/01 - 2017/06/16 Organization of parallel session: Immunity in Psychiatric syndromes during the Dutch Neuroscience Meeting, June 15th, 2017, Lunteren (Netherlands) Role: Co-organization, Discussion Chair, and speaker (2017/07/15 - 2017/07/15)
Conferência (Coorganizador)
2015/01/01 - 2015/04/18 9th MHeNs Translational Neuroscience Workshop “When the brain is under attack: Auto-antibodies and neurotransmitters as key player in neurological and psychiatric diseases” was organized April 2015 for the PhD students of MHeNs at Maastricht University Role: Co-organization, discussion leader and moderator: guide a group discussion on different research questions (2015/04/15 - 2015/04/15)
Oficina (workshop) (Coorganizador)
Universiteit Maastricht, Países Baixos

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2023/02/24 - Atual Trainee event organized by the PsychoNeuroImmunology Research Society. Oral presentation:” Complement genes are differentially methylated in the prefrontal cortex of individuals with schizophrenia: a meta-analysis”.
Encontro
PNIRS trainee event
2023/05/03 - 2023/05/05 At Regional FENS, SPN aims to boost the development of neuroscience at national and regional levels by organising a meeting with an outstanding scientific programme reflecting the latest breakthroughs in neuroscience, as well as its diversity.
Conferência
Regional FENS
Algarve Biomedical Center Research Institute, Portugal
2022/12/06 - 2022/12/07 Poster presentation: In-Situ methylation analysis of complement genes in the frontal cortex of individuals with Schizophrenia
Conferência
Aging without borders
2022/10/16 - 2022/10/17 I represented the ABC-RI to give the general public and especially the younger generation an insight into what happens at our research institute. We playfully explained the differentiation of different neuronal cells with a dice game where student and their families could walk the path of differentiation/self-renewal/apoptosis. These games were a good starting point for conversations with the participants to trigger their curiosity for the topic.
Festival
FICA – “Festival Internacional de Ciência 2022” in Oeiras
2018/11/15 - 2018/11/17 The Lancet Summit: Inflammation and Immunity in Disorders of the Brain and Mind, Barcelona Spain Poster: C. Hoffmann, J. Stevens, S. Zong,et al. Alpha7 acetylcholine receptor autoantibodies detected with a new radioimmunoassay are rare in sera of patients diagnosed with schizophrenia or bipolar disorder. Poster:C. Hoffmann, S. Zong, M. Mané Damas, et.al. Prevalence of neuronal and systemic autoantibodies in sera of patients with psychotic disorders and mental disorders without psychosis.
Conferência
The Lancet Summit: Inflammation and Immunity in Disorders of the Brain and Mind
2016/04/06 - 2016/04/10 10th international congress on autoimmunity, Leibzig (Germany) Poster with pitch presentation: Hoffmann, C., Stevens, J., Damas, M., et al. Analysis of auto-antibodies in psychotic disorder Chair of poster presentation session
Congresso
10th international congress on autoimmunity
2015/03/26 - 2015/03/27 The Lancet Neurology Autoimmune Disorders Conference, Barcelona (Spain) Poster: Hoffmann, C., Kishore Malyavantham, K., Lindemann, M.J., et al. Analysis of auto-antibodies in psychotic disorder
Conferência
The Lancet Neurology Autoimmune Disorders Conference
2015/03/13 - 2015/03/13 Symposium "The immune-brain axis: from molecules to behavior", Hasselt (Belgium) Oral presentation: Hoffmann , C., Kishore Malyavantham, K., Lindemann, M.J., et al. Analysis of auto-antibodies in psychotic disorder
Simpósio
Symposium "The immune-brain axis: from molecules to behavior"
2014/11/09 - 2014/11/13 12th International Congress of Neuroimmunology (ICNI), Mainz (Germany) Poster: Hoffmann, C., Lindemann, M.J., Ramsperger, V.C., et al. Analysis of autoantibodies in Schizophrenia Poster: Hoffmann, C., Nogales-Gadea, G., Stevens et al. Analysis of pathogenic autoantibodies against the N-methyl-D-aspartate glutamate receptor in schizophrenia *received travel grant to attend the conference from the German Multiple Sclerosis Society (DMSG)
Conferência
12th International Congress of Neuroimmunology
2014/05/23 - 2014/05/24 12th Endo-Neuro-Psycho meeting, Lunteren (Netherlands) Oral presentation: Hoffmann, C., Nogales-Gadea, G., Stevens, et al. Analysis of pathogenic autoantibodies against the N-methyl-D-aspartate glutamate receptor in schizophrenia
Conferência
12th Endo-Neuro-Psycho meeting
2014/03/28 - 2014/03/30 9th international congress on autoimmunity in Nice, France Oral presentation: Hoffmann, C., Nogales-Gadea, G., Stevens, J. et al. Analysis of pathogenic autoantibodies against the N-methyl-D-aspartate glutamate receptor in schizophrenia Poster: Hoffmann, C., Lindemann, M.J., Ramsperger, V.C., et al. Analysis of autoantibodies in Schizophrenia
Conferência
9th international congress on autoimmunity

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023/11/06 - Atual lecture on cell culture and applications for biomedical research Biomedical Sciences (Master) Maastricht Universitair Medisch Centrum+, Países Baixos
2023/01 - Atual Lecture in the 2nd year medical course at Maastricht University as part of “Expert lectures” on the topic of “Autoantibodies in the brain”. International Bachelor (BA) of Medicine (Bachelor) Maastricht Universitair Medisch Centrum+, Países Baixos
2022/11/07 - 2022/11/23 Practical classes within the course of "Gene and Cell Therapy" with the topic "Testing molecular activation of autophagy as therapeutic strategy in a cell model of Huntington´s disease. Biomedical Sciences (Licenciatura) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2015/09/05 - 2018/11/30 2015, 2016, 2017, and 2018 Lecture topics incl. neuroimmunology, immune system of the central nervous system, autoimmunity in psychotic disorders Tutorials and journal Clubs: fundamental of Neurosciences, Neuroimmunology, research methods Practical laboratory classes: Human anatomy, Sheep brain dissection practical, Cell based ELISA,Cell culture, Immunohistochemistry on rat brain, ELISA, and Dot-Blot, fundamental Neuroscience (master),Biomedicine(Bachelor and Master),health sciences(Bachelor and Master), and Medicine (Master) (Master) Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2023/08 - Atual As memebr of the organizing committe of the ABC-RI days, I am organizing, divulgating and executing bi-monthyl guided tours through our research institute.
Membro
Algarve Biomedical Center Research Institute, Portugal
Distinções

Prémio

2013 Award for the 3rd best Poster on the EURON days
European Graduate School of Neuroscience, Países Baixos

Outra distinção

2020 Scientific Employment stimulus - Individual fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2018 Kootstra PostDoc Talent Fellowship
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos
2018 Travel grant
The International Society of Neuroimmunology, Itália
2016 EMBO travel grant
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Alemanha
2016 Short Term Travel grant Boehringer Ingelheim Fonds
Boehringer Ingelheim International GmbH, Alemanha
2014 Graduate School of Translational Neuroscience PhD fellowship
Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Países Baixos
2013 Koostra Student Talent Fellowship
Universiteit Maastricht Faculty of Health Medicine and Life Sciences, Países Baixos