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Joana FM Pires is a PhD student at Faculty of medicine and Multidisciplinary Institue of Ageing at University of Coimbra, and enrolled in the Doctoral Program in Health Sciences since 2025, and a member of the Organelle Crosstalk in Aging and Disease Group led by Dr. Nuno Raimundo. Her research focuses on understanding how mitochondria–lysosome communication regulates neuronal metabolism and contributes to disease susceptibility. Joana holds a BSc in Biomedical Sciences and an MSc in Molecular Biomedicine from the University of Aveiro. During her Master’s thesis at the European Neuroscience Institute Göttingen, she studied the expression and localization of amisyn (STXBP6) across the mouse lifespan, contributing to the understanding of its role in exocytosis and SNARE complex regulation. Throughout her academic career, Joana has been awarded competitive funding, including Erasmus scholarships and a research fellowship within the H2020 project MindGAP, where she contributed to the development of a portable biosensor targeting brain extracellular vesicles. This work led to an oral presentation at the ISEV Annual Meeting 2021. Currently, she is involved in multiple research projects funded by FCT and ERC-Portugal, where she applies advanced methodologies in molecular and cellular biology, confocal imaging, and mitochondrial characterization. Joana co-author of a book chapter and has contributed to scientific articles under review in leading journals, including Trends in Cell Biology and Cell and has contributed to peer-reviewed scientific publications, including an article published in the high-impact journal EMBO Reports. Beyond academia, Joana has actively engaged in science communication and innovation, serving as regional coordinator of the Pint of Science and participating in international entrepreneurship initiatives, including pitch competitions and hackathons focused on translating scientific knowledge into real-world applications. Her profile combines strong experimental expertise with a growing interest in translational research and innovation, positioning her at the interface between fundamental science and its application to human health.
Identificação

Identificação pessoal

Nome completo
Joana Filipa Mariano Pires

Identificadores de autor

Ciência ID
201F-B779-DEA5

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2025/01/01 - 2029/01/01
Em curso
Doctoral Program in Health Sciences (Doutoramento)
Especialização em Especialização em Biomedical Sciences
Universidade de Coimbra Faculdade de Medicina, Portugal
"Stimulation of lysosomal function as a therapeutic strategy in Leigh syndrome" (TESE/DISSERTAÇÃO)
2025/10/15 - 2025/11/10
Concluído
Specialization Course in Experimental Methods in Mitochondrial Physiology (Outros)
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
17/20
2025/06/27 - 2025/06/27
Concluído
Oxygen Physiology and Respirometry in Biomedical Research (Outros)
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2025/05/28 - 2025/05/28
Concluído
13th Workshop of Lipidomics in health & diseases (Outros)
Universidade de Aveiro Departamento de Química, Portugal
2024/09/03 - 2024/09/13
Concluído
Summer School in Computational Biology (Outros)
Universidade de Coimbra, Portugal
2022/11/15 - 2023/02/17
Concluído
Laboratory Animal Science course (Function A & SS) (Outros)
Especialização em Function A + Modules 20, 21 and 22 - Equivalent to FELASA B training
Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2021/07/02 - 2021/07/29
Concluído
Cell Culture and Tissue Training Course (Outros)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/10/02 - 2020/11/19
Concluído
Clinical Investigator Certification Level 1 (Outros)
Universidade de Aveiro Associação para a Formação Profissional e Investigação, Portugal
2018/09/17 - 2020/07/14
Concluído
Molecular Biomedicine (Mestrado)
Especialização em Neuroscience, Molecular Biology
Universidade de Aveiro, Portugal
"Characterization of amisyn expression and localization in the brain over mouse lifespan" (TESE/DISSERTAÇÃO)
17
2015/09/19 - 2018/07/30
Concluído
Biomedical Science (Licenciatura)
Universidade da Beira Interior, Portugal
"Laser application in the treatment of Benign Prostatic Hyperplasia" (TESE/DISSERTAÇÃO)
13
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2025/01/01 - Atual Investigador (Investigação) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/12/15 - 2024/12/31 Gestão de Ciência e Tecnologia Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2020/12/15 - 2021/12/15 Investigador (Investigação) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
BioMark Sensor Research, Universidade de Coimbra - , Portugal
2019/09/01 - 2020/02/29 Estagiário de Investigação (Investigação) Europäisches Neurowissenschaftliches Institut Göttingen, Alemanha
Universitätsmedizin Göttingen, Alemanha
2017/07 - 2017/09 Estagiário de Investigação (Investigação) Instituto de Biomedicina de Sevilla, Espanha
Instituto de Biomedicina de Sevilla, Espanha
Projetos

Bolsa

Designação Financiadores
2025/01/01 - Atual Stimulation of lysosomal function as a therapeutic strategy in Leigh syndrome
2024.01142.BD C
Bolseiro de Doutoramento
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2020/12/15 - 2021/12/15 MindGAP - Bridging the gap between Mind, Brain and Body: exosome role and monitoring (GA829040)
Bolseiro de Investigação
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
EU Framework Programme for Research and Innovation Euratom
Em curso
2019/09/01 - 2020/01/31 Characterization of amisyn expression and localization in the brain over mouse lifespan
Bolseiro de Mestrado
Europäisches Neurowissenschaftliches Institut Göttingen, Alemanha
Concluído

Projeto

Designação Financiadores
2023/03/01 - 2024/08/31 Different intracellular AMPK pools modulate mitochondria-ER contact sites
2022.04407.PTDC
Investigador
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso

Outro

Designação Financiadores
2017/07/13 - 2017/09/13 New therapeutic alternatives to treat adenovirus infections
USE-13901-D
Bolseiro de Iniciação Científica
Universidad de León Instituto de Biomedicina, Espanha
Concluído
Produções

Publicações

Artigo em revista
  1. Domingues, Neuza; Joana F. Pires; Milosevic, Ira; Raimundo, Nuno. "Role of lipids in inter-organelle communication". Trends in Cell Biology (2024):
    No prelo
Capítulo de livro
  1. Carvalho, Cristina; Pires, Joana; Paula I. Moreira; Raimundo, Nuno. "Disrupted cellular quality control mechanisms in aging". In Aging From Fundamental Biology to Societal Impact, editado por Paulo J. Oliveira; João O. Malva. Portugal: Elsevier, 2022.
    Publicado • 10.1016/c2020-0-00576-1
Poster em conferência
  1. Joana F. Pires; Coelho, Patrícia ; Sardão, Vilma; Domingues, Neuza; Raimundo, Nuno. "Primary lysosomal dysfunction induces early mitochondrial vulnerability and impaired organelle crosstalk in CLN3-deficient cells". Trabalho apresentado em Coimbra International Meeting in Health Sciences and Technology (CIMHealth), 2026.
  2. Joana F. Pires; Domingues, Neuza; Milosevic, Ira; Raimundo, Nuno; Coelho, Patrícia. "PIKfyve Control of Mitochondria–Lysosome Crosstalk in Leigh Syndrome". Trabalho apresentado em Coimbra International Meeting in Health Sciences and Technology (CIMHealth), 2026.
  3. Joana F. Pires; Domingues, Neuza; Milosevic, Ira; Raimundo, Nuno. "PIKfyve: Innovative Pathways for Mitochondrial Diseases". Trabalho apresentado em I Young Biochemist Meeting, 2025.
  4. Joana F. Pires; Jialin Jin; Milosevic, Ira. "Amisyn expression and distribution in the mammalian aged brains". Trabalho apresentado em RESETageing conference 2023, 2023.
  5. Domingues, Neuza; Joana F. Pires; Raimundo, Nuno. Autor correspondente: Raimundo, Nuno. "Unveiling the molecular mechanisms of Batten disease in the absence of CLN3". Trabalho apresentado em Gordon Research Conference Lysosomal Diseases, 2023.
Pré-impressão
  1. Domingues, Neuza; Calcagni’, Alessia; Pires, Joana; Freire, Sofia Roque; Herz, Niculin Joachim; Huynh, Tuong; Wieciorek, Katarzyna; et al. "Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling". 2024. http://dx.doi.org/10.1101/2024.05.31.596474.
    10.1101/2024.05.31.596474
Resumo em conferência
  1. Manuela Maria Teixeira Basto de Faria Frasco; Mariana Amorim ; Joana F. Pires; Maria Goreti Ferreira Sales. "Plastic antibodies tailored as photonic materials for sensing extracellular vesicles". Trabalho apresentado em ISEV2022, Journal of Extracellular Vesicles, 2022.
    Publicado • 10.1002/jev2.12224
Tese / Dissertação
  1. "Characterization of amisyn expression and localization in the brain over mouse lifespan". Mestrado, Universidade de Aveiro Departamento de Ciências Médicas, 2020. https://ria.ua.pt/handle/10773/29008.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2026/01/18 Role of PIKfyve in Mitochondria–Lysosome Crosstalk in Leigh Syndrome 2nd Winter School in Mitochondrial Biomedicine
( Bressanone , Itália)
2025/06/09 Start'Ship Pitch Competition: Participation in an entrepreneurship and innovation pitch competition,involving the development and pitching of a startup project (SimCom), demonstrating strategic thinking and innovation skills. START’ship Pitch Competition 2025
Commercialization Reactor
2023/05/30 Characterization of amisyn expression and localization in the brain over mouse lifespan "Weekly @CNC" Seminar
(Coimbra, Portugal)
2023/05/13 Unveiling the molecular mechanisms of Batten disease in the absence of CLN3 Gordon Research Conference (GRC) 2023
GRC Frontiers of Science Fund (Barcelona, Espanha)
2022/05/26 Plastic antibodies adapted as photonic materials for detection of extracellular vesicles. ISEV 2022 meeting
International Society for Extracellular Vesicles (Lyon, França)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2025/02/03 - 2025/02/04 Part of organising committee in the 2025 of MAD Meeting - Metabolism, Aging and Disease meeting, 5th CIBB retreat. As a member of the organization, I helped with the assembly and placement of the posters, participants' registration and logistics during the oral presentations. (2025/02/03 - 2025/02/04)
Conferência (Membro da Comissão Organizadora)
Universidade de Coimbra, Portugal
2023/09/29 - 2023/09/29 2023 European Researchers' Night (2023/09/29 - 2023/09/29)
Oficina (workshop) (Membro da Comissão Científica)
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2022/10 - 2022/10 FIC.A - Festival Internacional de Ciência 2022 (2022/10 - 2022/10) (2022/10 - 2022/10) Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2022/09/30 - 2022/09/30 2022 European Researchers' Night (2022/09/30 - 2022/09/30)
Oficina (workshop) (Membro da Comissão Organizadora)
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2022/04/04 - 2022/04/08 Ageing Spring School 2022 (2022/04/04 - 2022/04/08) (2022/04/04 - 2022/04/08)
Conferência
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal
2017/03/08 - 2017/03/11 Participation in the organization of the event "VIII National Biomedical Sciences Conference". The Journeys consist in the debate of themes inherent to biomedical research in Portugal and of the scientific community. The lectures focus on areas such as Biomaterials, Bioinformatics, Instrumentation, Neuroscience, Forensic Sciences, with prestigious names of Portuguese science. (2017/03/08 - 2017/03/11)
Conferência (Outra)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2026/03/16 - 2036/03/16 2026 Semana Internacional do Cérebro | CiBB
Seminário
Semana do Cérebro 2026
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2025/06/30 - 2025/07/01 Congress that brought together works that focus in interconnected mechanisms of ageing, tissue degeneration, stem cell dysfunction, regenerative medicine, and emerging therapies, held in Coimbra (Portugal), in the year 2025. During the two days, I attended several seminars.
Simpósio
1st Symposium on Ageing of the Vascular, Immune, Haematopoetic and Musculoskeletal Systems
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal, Portugal
2025/05/26 - 2025/05/27 BEB Day 2025: “From Microscales to Macroworlds: Transcending the Limits of Science”
Simpósio
BEB Day 2025: “From Microscales to Macroworlds: Transcending the Limits of Science”
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2025/05/21 - 2025/05/22 Hackathon Start’Ship: Participation in the Student x CEO Hackathon the Start’Ship Erasmus+ project, involving collaboration with entrepreneurs and development of a business concept (“SNS+ YOU CARE”), presented in a competitive innovation environment.
Oficina (workshop)
Hackathon Start’Ship,
Universidade de Coimbra Faculdade de Medicina, Portugal
2025 - 2025 Webinar Series: “Fundamentals of the Publicase Method for Writing Scientific Papers”, designed for early-career scientists working in the biological and biomedical fields. This course was given by Publicase International.
Oficina (workshop)
Fundamentals of the Publicase Method for Writing Scientific Papers
2025 - 2025 2025 European Researchers' Night
Exposição
European Researchers' Night
Universidade de Coimbra Multidisciplinary Institute of Ageing, Portugal, Portugal
2024/08/01 - 2024/08/01 Dissemination of science by the University of Coimbra in the Education Space at Expofacic in Cantanhede, offering interactive activities for all ages, with a special focus on young people.
Outro
EXPOFACIC | Atelier da Ciência UC, MIA-Portugal
Universidade de Coimbra, Portugal
2024/02/07 - 2024/02/07 SEMANA DA CIÊNCIA UC, Escola Secundária Artur Gonçalves de Torres Novas, promoted by the University of Coimbra. The activity comprised the ecomprised a lecture/introduction and hands-on on the genetics of aging, with the participation of high-school students.
Universidade de Coimbra, Portugal
2023/12/04 - 2023/12/07 EIT Health Ageing PhD School Annual Retreat 2023
Encontro
EIT Health Ageing PhD School Annual Retreat 2023
EIT Health, Alemanha
2021/06/29 - 2021/06/29 8th Biotech Health Annual Symposium: Biotech Talks | The Future is Now
Simpósio
8th BiotechHealth Annual Symposium, “Biotech Talks | The Future is Now”
Universidade do Porto, Portugal
2018/11/20 - 2018/11/20 Participation in conference "Signalling Afternoon" whose main focus was the debate on cell signaling pathways and their fundamental role in the processes of proliferation, growth, differentiation and cell death.
Conferência
Signalling Afternoon
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018/07/05 - 2018/07/06 Participation "XII Annual CICS-UBI Symposium" whose main objective was to make known the research being carried out at the Health Sciences Research Centre in the fields of biomedical, biotechnological and drug development research, diagnosis, omonitoring and treatment of diseases existing in modern societies.
Simpósio
XII Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018/02/23 - 2018/02/23 Participation in the "I Encontro das Tecnologias da Saude da CHCB" promoted by the Technical Council of Diagnosis and Therapy of the CHCB intends to share knowledge and experiences among all Health Technicians in the areas of diagnosis and therapy, intervenient in diagnosis and research. The central theme of this meeting was entitled "Evaluate, Diagnose and Treat".
Encontro
I Encontro das Tecnologias da Saude da CHCB - Evaluate, Diagnose and Treat
Centro Hospitalar Cova da Beira EPE, Portugal
2018 - 2018 Participation in a children's volunteer project - "Hospital da Faz de Conta" Faculty of Health Sciences, UBI(2018) that helped me develop capacities such as solidarity, responsibility and communication with children.
Encontro
Hospital Faz de Conta
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2017 - 2018 Participation in a children's volunteer project - "Canto da Cigarra" Cova da Beira Hospital Center, (Covilhã) which aims to humanize the hospital space by providing psychosocial well-being to children under 12 years of age.
Encontro
Canto da Cigarra
Centro Hospitalar Cova da Beira EPE, Portugal
2016/11/09 - 2016/11/30 Participation in the "II Cycle of Biomedical Conferences in the Afternoon" where researchers from different areas expose the research that is being done in Biotechnology, Reproduction Biology, Medical Devices/Biosensors, Biomaterials, Neurophysiology, Oncobiology, Entrepreneurship and Medical Imaging.
Conferência
II Cycle of Biomedical Conferences in the Afternoon
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Membro de associação

Nome da associação Tipo de participação
2025 - Atual Portuguese Biochemical Society Adherent member
2024 - Atual GreenLabsCIBB GreenKeeper

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2021/10 - 2023/05 She is the coordinator of Coimbra Pint of Science - an international science festival that makes scientific discussion accessible to the whole population in order to bridge the communication gap that exists in this area.
Coordenador

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2023/06/14 - Atual International Journal of Biochemistry and Cell Biology (1357-2725)

Tutoria

Tópico Nome do aluno
2026/02/01 - 2026/03/01 Laboratory Rotation: "The impact of lysosomal dysfunction on lipid droplet dynamics in human cells" Mariana Rego
Distinções

Prémio

2025 Start'Ship Pitch Competition Finalist
Commercialization Reactor , Letónia
2024 PhD fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2023 Travel Award to participate in 22nd International Symposium on Chromaffin Cell Biology 2024