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P Pereira (M) (h-index: 41; i10: 68; citations:7700) is currently a Group Leader (since 2016) and the coordinator of the Research Unit Inova4Health and the Associated Laboratory LS4Future at Nova Medical School. Paulo received a PhD in Cell Biology (1997) and the title habilitation (2007) from the University of Coimbra and he also worked at the Division of Clinical Toxicology, University College of London and at Tufts University, Boston, USA. Paulo was the Presidente of the Executive Board of CEDOC- Center for the Study of Chronic Diseases at UNL, Vice-Dean for research at Faculty of Medicine University of Coimbra, Vice-President of the Portuguese Science Foundation (FCT), Portuguese Delegate to ESFRI Research Infrastructures (EC), Portuguese Delegate to the High level Group for Joint Programming Committee (EC), Representative to the General Assembly of the European Science Foundation (ESF), among other national and international positions. P Pereira Published 88 articles in peer reviewed journals. Has published 6 book Chapter(s). Has 1 patent(s) registered. Supervised 6 Postdocs and 25 PhD theses. Has received 2 awards and/or honors. Participates and/or participated as Principal investigator in 18 project(s)/grants with external funding. His research interests include the study of molecular mechanisms of age-related diseases and particularly retinal diseases such as Age-related macular degeneration. P Pereira made important contributions on regulation of proteostasis upon ageing and diseases and particularly on the pivotal role of proteolysis and extracellular vesicles on ageing and age-related diseases.
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Identificação

Identificação pessoal

Nome completo
Paulo Pereira
Data de nascimento
1967/03/09
Género
Masculino

Nomes de citação

  • Pereira, Paulo
  • Paulo C Pereira
  • P C Pereira

Identificadores de autor

Ciência ID
1F1D-B041-D79F
ORCID iD
0000-0002-9908-2290
Google Scholar ID
https://scholar.google.pt/citations?hl=pt-PT&user=w8GsNC4AAAAJ
Scopus Author Id
7202938155

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica
  • Ciências Médicas e da Saúde - Ciências da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2007
Concluído
 Vision Sciences (Título de Agregado)
Universidade de Coimbra Faculdade de Medicina, Portugal
1997
Concluído
 Cell Biology (Doutoramento)
Universidade de Coimbra, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 Aproved
1990
Concluído
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Biochesmitry" (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2017 - Atual Investigador Coordenador (carreira) (Investigação) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2016 - Atual Investigador Coordenador (carreira) (Investigação) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2008 - 2013 Investigador Coordenador (carreira) (Investigação) Universidade de Coimbra Centro de Oftalmologia e Ciências da Visão, Portugal
2007 - 2012 Investigador principal (carreira) (Investigação) Universidade de Coimbra Centro de Oftalmologia e Ciências da Visão, Portugal
1998 - 2001 Investigador (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
1999 - 2000 Investigador visitante (Investigação) Tufts University School of Medicine, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/03/01 - Atual Professor Catedrático (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2019 Professor Catedrático Convidado (Docente Universitário) Universidade Nova de Lisboa, Portugal
2016 - 2019 Professor Catedrático Convidado (Docente Universitário) Universidade de Coimbra, Portugal
2013 - 2016 Professor Catedrático (Docente Universitário) Universidade de Coimbra Faculdade de Medicina, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2022 - Atual Coordinator of the research unit iNOVA4Health, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/04/02 - 2022/04/01 Presidente Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2012/01/02 - 2016/03/01 Vice-Presidente Fundação para a Ciência e a Tecnologia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2012 - 2016 Invited Full Professor Universidade de Coimbra Faculdade de Medicina, Portugal
2012/01/01 - 2015/02/01 Portuguese Delegate to de ESFRI-European Strategic Forum for Research Infrastructures European Commission, Bélgica
2012/01/01 - 2015/02/01 Portuguese Delegate to the High level Group for Joint Programming Committee European Commission, Bélgica
2012/01/01 - 2015/02/01 Member of the general assembly of the JRC-Joint Research Center of the European Union European Commission, Bélgica
2012/01/01 - 2015/01/02 Portuguese Alternate Delegate for the ERAC-European Research Area Committee European Commission, Bélgica
2007/01/01 - 2015/01/02 Coordinator of the Research Class and integrate Master in medicine Universidade de Coimbra Faculdade de Medicina, Portugal
2012/01/03 - 2015/01/01 Portuguese Representative to the General Assembly of the European Science Foundation (ESF) European Science Foundation, França
2012/01/01 - 2015/01/01 Portuguese representative to the Committee for Research Infrastructures in the 7th Framework pPogramme European Union, Bélgica
2009/01/01 - 2015 Member of commision of PhD Inter-University Doctoral Programme in Ageing and Degeneration of Complex Biological System Universidade de Coimbra Faculdade de Medicina, Portugal
2009/01/01 - 2014/01/01 Coordinator of the Master in Biomedical Research Universidade de Coimbra Faculdade de Medicina, Portugal
2009/11/16 - 2011/11/15 Vice-Dean Universidade de Coimbra Faculdade de Medicina, Portugal
2009/01/01 - 2011/01/01 Coordinator Investigator Universidade de Coimbra Faculdade de Medicina, Portugal
2008/01/01 - 2011/01/01 Director of Centre of Ophthalmology Universidade de Coimbra Faculdade de Medicina, Portugal
2007/01/01 - 2011/01/01 Director of Laboratory for electron microscopy (National Network of electron microscopy) Universidade de Coimbra, Portugal
2002/01/01 - 2011/01/01 Advanced course coordinator: Biology of proteolysis (BEB PhD programme) Universidade de Coimbra Faculdade de Medicina, Portugal
2005 - 2011 Director of the Laboratory for Research in Biology of Ageing Universidade de Coimbra Faculdade de Medicina, Portugal
2001 - 2011 Portuguese supervisor IOBA (Interuniversity PhD Programme in Visual Sciences) Universidade de Coimbra Faculdade de Medicina, Portugal
2000 - 2011 Director of the Laboratory of Bio-imaging and Confocal Universidade de Coimbra Faculdade de Medicina, Portugal
2007/01/01 - 2009/01/01 Member of Board of Directors Universidade de Coimbra Faculdade de Medicina, Portugal
2001 - 2004 Member of GAI (Office for Sicentific Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2023 - Atual Extracellular vesicles are critical players in the transcellular regulation of proteostasis in Age-related Macular Degeneration (Funding: 250 K€)
2022.08649.PTDC
Investigador responsável
iNOVA4Health, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - Atual The Science of testing for COVID-19: Towards improved diagnostics and better health solutions. 300.000€
02/SAICT/2020-72552
Investigador responsável
iNOVA4Health, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
Concluído
2018/10/01 - Atual Lysosome dysfunction in age-related diseases
PTDC/MED-PAT/30385/2017
Co-Investigador Responsável (Co-IR)
Fundação para a Ciência e a Tecnologia
Concluído
2017/12 - Atual iNOVA4Health - UIDB/Multi/04462/2020 and UIDP/Multi/04462/2020 - "Engineered exosomes as new therapeutic tools to restore proteostasis in age-related degenerative diseases" , 50.000€
REF32 2017
Investigador responsável
iNOVA4Health
2010 - 2014 "An animal model for age-related changes in proteostasis"
PTDC/SAU-ORG/118694/2010
Investigador responsável
Fundação para a Ciência e a Tecnologia
2010/02/01 - 2013 Functional genomics studies of phagocytosis in retinal pigment epithelium
info:eu-repo/grantAgreement/FCT/3599-PPCDT/105175/PT
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
2010 - 2013 Regulation of retinal growth factors secretion by Rab GTPases
PTDC/SAU-OSM/104668/2008
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2009 - 2013 Tumorigenesis as a working model for the physiological role of HIF-1alpha degradation by chaperone-mediated autophagy
FCT - PTDC/SAU-ORG/113542/2009
Investigador responsável
Fundação para a Ciência e a Tecnologia
2009 - 2011 "A new route for endothelial dysfunction on diabetes: From phenotypes to molecules" 2009-2011
FCT - PTDC/SAU-OSM/67498/2006
Investigador responsável
Fundação para a Ciência e a Tecnologia
2005 - 2009 FCT - REDE/1510/RME/2005 "Molecular mechanisms of cell damage and ageing"
FCT - REDE/1510/RME/2005
Investigador responsável
Fundação para a Ciência e a Tecnologia
2005/03/01 - 2008/03/01 "What HIF? Degradation is better than growth in preventing angiogenesis in diabetic retinopathy"
FCT - POCI/SAU-OBS/57772/2004
Investigador responsável
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2004 - 2007 "Filling in the GAP: the missing link between intercellular communication and diabetic retinopathy"
FCT- POCI/SAU-MMO/57216/2004
Investigador responsável
Fundação para a Ciência e a Tecnologia
2004 - 2006 "Degradation and subcellular distribution of GLUT1 in endothelial cells following oxidative stress: implications on diabetic retinopathy"
CRUP- British Council B-1/04
Investigador responsável
British Council
2002/03/01 - 2005/03/01 Identification and phyisiological role of deubiquitinating enzymes in the lens: A novel function for ubiquitin
FCT – POCTI -
FCT POCTI -
Investigador responsável
Universidade de Coimbra, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior

Fundação para a Ciência e a Tecnologia
Concluído
2002 - 2005 Degradation of GLUT1 by ubiquitin proteasome pathway as a novel regulatory mechanism for glucose transport on diabetic retinopathy
FCT - POCTI -
Investigador responsável
Fundação para a Ciência e a Tecnologia
2002 - 2005 “Identification and phyisiological role of deubiquitinating enzymes in the lens: A novel function for ubiquitin”
FCT – POCTI -
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
1999 - 2001 "Age, diabetes and cataract related changes in ubiquitin - dependent proteolysis in human lens epithelial cells"
FCT - PRAXIS XXI
Investigador responsável
Fundação para a Ciência e a Tecnologia
1998 - 2000 "F2-Isoprostanes as Markers of Oxidative Injury in Human retina" 1998
CRUP- British Council B3/98
CRUP- British Council B3/98
Investigador responsável
British Council Portugal
Concluído
1997 - 1999 "Implications of cholesterol oxidation in Human cataract formation"
JNICT -PRAXIS XXI
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
1998 - 1998 "Age Related Elimination of Oxidized Proteins as Potential Cause of Cataract"
CRUP- British Council B4/98
Investigador responsável
British Council

Projeto

Designação Financiadores
2022 - Atual EVCA Twinning on Extracellular Vesicles (Funding: 1,2 M€)
Grant agreement ID: 101079264
Co-Investigador Responsável (Co-IR)
Horizon 2020
Em curso
2017/09/01 - 2019/11/30 Correction of lysosomal dysfunction in Retinal Pigmented Epithelial (RPE) cells (325 Keuros)
_
Investigador
Universidade Nova de Lisboa, Portugal

iNOVA4Health, Portugal
Boehringer Ingelheim Auslandsbeteiligungs GmbH
Concluído
Produções

Publicações

Artigo em revista
  1. Ferreira, João Vasco; da Rosa Soares, Ana; Pereira, Paulo. "LAMP2A mediates the loading of proteins into endosomes and selects exosomal cargo". Autophagy 18 9 (2022): 2263-2265. http://dx.doi.org/10.1080/15548627.2022.2092315.
    Publicado • 10.1080/15548627.2022.2092315
  2. Ferreira, Joao Vasco; da Rosa Soares, Ana; Pereira, Paulo. "Cell Non-autonomous Proteostasis Regulation in Aging and Disease". Frontiers in Neuroscience 16 (2022): http://dx.doi.org/10.3389/fnins.2022.878296.
    Publicado • 10.3389/fnins.2022.878296
  3. Saba Abdulghani; Ângela Afonso; Mireia Castillo; Javier Martín-Fernández; Inês Franco; Bruna Parreira; Ana Couto; et al. "The Role of Biobanks in the Fight against COVID-19 Pandemic". Acta Médica Portuguesa 35 13 (2022): https://novaresearch.unl.pt/en/publications/d784754a-7bad-46a7-9f39-ac156555ff2e.
    10.20344/amp.17856
  4. Ferreira, João Vasco; da Rosa Soares, Ana; Ramalho, José; Máximo Carvalho, Catarina; Cardoso, Maria Helena; Pintado, Petra; Carvalho, Ana Sofia; et al. "LAMP2A regulates the loading of proteins into exosomes". Science Advances 8 12 (2022): http://dx.doi.org/10.1126/sciadv.abm1140.
    Acesso aberto • 10.1126/sciadv.abm1140
  5. Silva, Filipe; Ferreira, Filipa; Faria, Pedro; Sobral, Isa; Rodrigues, Mariana; Pratas, João; Silva, João Filipe; et al. "MYOC Gene Sequencing Analysis in Primary Open-Angle Glaucoma Patients from the Centre Region of Portugal". Acta Médica Portuguesa 34 9 (2021): 586. http://dx.doi.org/10.20344/amp.14922.
    Acesso aberto • Publicado • 10.20344/amp.14922
  6. Pereira, Paulo. "The early dynamics of the SARS-CoV-2 epidemic in Portugal". MedRxiv (2021): https://doi.org/10.1101/2021.02.22.21252216.
    Acesso aberto • Publicado
  7. Borges, Vítor; Isidro, Joana; Cortes-Martins, Helena; Duarte, Sílvia; Vieira, Luís; Leite, Ricardo; Gordo, Isabel; et al. "Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal". Emerging Microbes & Infections 9 1 (2020): 2488-2496. http://dx.doi.org/10.1080/22221751.2020.1844552.
    Acesso aberto • Publicado • 10.1080/22221751.2020.1844552
  8. Joao Vasco Ferreira; Ana Rosa Soares; José S. Ramalho; Teresa Ribeiro-Rodrigues; Catarina Máximo; Mónica Zuzarte; Henrique Girão; Paulo Pereira. "Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis". PLOS ONE 14 10 (2019): e0223790-e0223790. https://doi.org/10.1371/journal.pone.0223790.
    Acesso aberto • Publicado • 10.1371/journal.pone.0223790
  9. Almeida Paiva, Rafael; Martins-Marques, Tania; Jesus, Katia; Ribeiro-Rodrigues, Teresa; Zuzarte, Monica; Silva, Ana; Reis, Liliana; et al. "Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation". Journal of Cellular and Molecular Medicine 23 2 (2018): 1137-1151. http://dx.doi.org/10.1111/jcmm.14014.
    Acesso aberto • Publicado • 10.1111/jcmm.14014
  10. Anjo, Sandra I.; Martins-Marques, Tania; Pereira, Paulo; Girão, Henrique; Manadas, Bruno. "Elucidation of the dynamic nature of interactome networks: A practical tutorial". Journal of Proteomics 171 (2018): 116-126. http://dx.doi.org/10.1016/j.jprot.2017.04.011.
    Publicado • 10.1016/j.jprot.2017.04.011
  11. Bover, O.; Justo, T.; Pereira, P.N.G.; Facucho-Oliveira, J.; Inacio, J.M.; Ramalho, J.S.; Domian, I.J.; Belo, J.A.. "Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells". PLoS ONE 13 10 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85054434702&partnerID=MN8TOARS.
    10.1371/journal.pone.0205108
  12. Catarino, Steve; Pereira, Paulo; Girão, Henrique. "Molecular control of chaperone-mediated autophagy". Essays in Biochemistry 61 6 (2017): 663-674. http://dx.doi.org/10.1042/ebc20170057.
    Publicado • 10.1042/ebc20170057
  13. Baptista, Rui; Marques, Carla; Catarino, Steve; Enguita, Francisco J; Costa, Marina C; Matafome, Paulo; Zuzarte, Mónica; et al. "MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1". Cardiovascular Research 114 1 (2017): 53-64. http://dx.doi.org/10.1093/cvr/cvx187.
    Acesso aberto • Publicado • 10.1093/cvr/cvx187
  14. Ribeiro-Rodrigues, Teresa M.; Laundos, Tiago L.; Pereira-Carvalho, Rita; Batista-Almeida, Daniela; Pereira, Ricardo; Coelho-Santos, Vanessa; Silva, Ana P.; et al. "Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis". Cardiovascular Research 113 11 (2017): 1338-1350. http://dx.doi.org/10.1093/cvr/cvx118.
    Acesso aberto • Publicado • 10.1093/cvr/cvx118
  15. Ramalho, Ana Rita; Toscano, Adriana; Pereira, Paulo; Girão, Henrique; Gonçalves, Lino; Marques, Carla. "Hyperglycemia-induced degradation of HIF-1a contributes to impaired response of cardiomyocytes to hypoxia". Revista Portuguesa de Cardiologia 36 5 (2017): 367-373. http://dx.doi.org/10.1016/j.repc.2016.09.018.
    Acesso aberto • Publicado • 10.1016/j.repc.2016.09.018
  16. Ribeiro, João Carlos; Oliveiros, Bárbara; Pereira, Paulo; António, Natália; Hummel, Thomas; Paiva, António; Silva, Eduardo D.. "Accelerated age-related olfactory decline among type 1 Usher patients". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep28309.
    Acesso aberto • Publicado • 10.1038/srep28309
  17. Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 2 (2016): 443-443. http://dx.doi.org/10.1080/15548627.2016.1147886.
    Acesso aberto • Publicado • 10.1080/15548627.2016.1147886
  18. Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://dx.doi.org/10.1080/15548627.2015.1100356.
    Acesso aberto • Publicado • 10.1080/15548627.2015.1100356
  19. Martins-Marques, Tania; Pinho, Maria Joao; Zuzarte, Monica; Oliveira, Carla; Pereira, Paulo; Sluijter, Joost P. G.; Gomes, Celia; Girao, Henrique. "Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin". Journal of Extracellular Vesicles 5 1 (2016): 32538. http://dx.doi.org/10.3402/jev.v5.32538.
    Acesso aberto • Publicado • 10.3402/jev.v5.32538
  20. Martins-Marques, Tania; Anjo, Sandra Isabel; Pereira, Paulo; Manadas, Bruno; Girão, Henrique. "Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart*". Molecular & Cellular Proteomics 14 11 (2015): 3040-3055. http://dx.doi.org/10.1074/mcp.m115.052894.
    Acesso aberto • Publicado • 10.1074/mcp.m115.052894
  21. Soares, Ana Rosa; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Ferreira, Joao Vasco; Catarino, Steve; Pinho, Maria João; Zuzarte, Monica; et al. "Erratum: Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep14888.
    Acesso aberto • Publicado • 10.1038/srep14888
  22. Soares, Ana Rosa; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Ferreira, Joao Vasco; Catarino, Steve; Pinho, Maria João; Zuzarte, Monica; et al. "Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep13243.
    Acesso aberto • Publicado • 10.1038/srep13243
  23. Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Pinho, Maria J.; Pereira, Paulo; Girao, Henrique. "Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive". Biochemical Society Transactions 43 3 (2015): 471-475. http://dx.doi.org/10.1042/bst20150036.
    Publicado • 10.1042/bst20150036
  24. Martins-Marques, Tânia; Catarino, Steve; Marques, Carla; Pereira, Paulo; Girão, Henrique. "To beat or not to beat: degradation of Cx43 imposes the heart rhythm". Biochemical Society Transactions 43 3 (2015): 476-481. http://dx.doi.org/10.1042/bst20150046.
    Publicado • 10.1042/bst20150046
  25. Vasco Ferreira, Joao; Rosa Soares, Ana; Silva Ramalho, Jose; Pereira, Paulo; Girao, Henrique. "K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep10210.
    Acesso aberto • Publicado • 10.1038/srep10210
  26. Martins-Marques, Tânia; Catarino, Steve; Marques, Carla; Matafome, Paulo; Ribeiro-Rodrigues, Teresa; Baptista, Rui; Pereira, Paulo; Girão, Henrique. "Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs". Biochimie 112 (2015): 196-201. http://dx.doi.org/10.1016/j.biochi.2015.02.020.
    Publicado • 10.1016/j.biochi.2015.02.020
  27. Martins-Marques, Tania; Catarino, Steve; Zuzarte, Monica; Marques, Carla; Matafome, Paulo; Pereira, Paulo; Girão, Henrique. "Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes". Biochemical Journal 467 2 (2015): 231-245. http://dx.doi.org/10.1042/bj20141370.
    Publicado • 10.1042/bj20141370
  28. Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Pereira, Paulo; Codogno, Patrice; Girao, Henrique. "Autophagy and Ubiquitination in Cardiovascular Diseases". DNA and Cell Biology 34 4 (2015): 243-251. http://dx.doi.org/10.1089/dna.2014.2765.
    Publicado • 10.1089/dna.2014.2765
  29. Martins-Marques, T.; Catarino, S.; Marques, C.; Pereira, P.; Girão, H.. "To beat or not to beat: Degradation of Cx43 imposes the heart rhythm". Biochemical Society Transactions 43 (2015): 476-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934934067&partnerID=MN8TOARS.
    10.1042/BST20150046
  30. Fernandes, Rosa; Bento, Carla F.; Matafome, Paulo; Sena, Cristina M.; Seiça, Raquel M.; Pereira, Paulo. "Atorvastatin-mediated protection of the retina in a model of diabetes with hyperlipidemia". Canadian Journal of Physiology and Pharmacology 92 12 (2014): 1037-1043. http://dx.doi.org/10.1139/cjpp-2014-0212.
    Publicado • 10.1139/cjpp-2014-0212
  31. Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Marques, Carla; Ferreira, João V.; Martins-Marques, Tânia; Pereira, Paulo; Girão, Henrique. "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions". The FASEB Journal 28 11 (2014): 4629-4641. http://dx.doi.org/10.1096/fj.13-248963.
    Acesso aberto • Publicado • 10.1096/fj.13-248963
  32. Crisóstomo, J.; Matafome, P.; Santos-Silva, D.; Rodrigues, L.; Sena, C.M.; Pereira, P.; Seiça, R.. "Methylglyoxal chronic administration promotes diabetes-like cardiac ischaemia disease in Wistar normal rats". Nutrition, Metabolism and Cardiovascular Diseases 23 12 (2013): 1223-1230. http://dx.doi.org/10.1016/j.numecd.2013.01.005.
    Publicado • 10.1016/j.numecd.2013.01.005
  33. Simões-Correia, Joana; Silva, Diana I.; Melo, Soraia; Figueiredo, Joana; Caldeira, Joana; Pinto, Marta T.; Girão, Henrique; Pereira, Paulo; Seruca, Raquel. "DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo". Human Molecular Genetics 23 8 (2013): 2094-2105. http://dx.doi.org/10.1093/hmg/ddt602.
    Acesso aberto • Publicado • 10.1093/hmg/ddt602
  34. Ferreira, João Vasco; Fôfo, Hugo; Bejarano, Eloy; Bento, Carla Figueira; Ramalho, José S.; Girão, Henrique; Pereira, Paulo. "STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy". Autophagy 9 9 (2013): 1349-1366. http://dx.doi.org/10.4161/auto.25190.
    Acesso aberto • Publicado • 10.4161/auto.25190
  35. Rodrigues, Lisa; Matafome, Paulo; Crisóstomo, Joana; Santos-Silva, Daniela; Sena, Cristina; Pereira, Paulo; Seiça, Raquel. "Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation". Journal of Physiology and Biochemistry 70 1 (2013): 173-184. http://dx.doi.org/10.1007/s13105-013-0291-2.
    Acesso aberto • Publicado • 10.1007/s13105-013-0291-2
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Capítulo de livro
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  4. Coelho, J.F.J.; Ferreira, P.; Fonseca, A.C.; Fernandes, A.F.; Pereira, P.; Seiça, R.; Gil, M.H.. "Advanced drug delivery systems in diabetes treatment". In Predictive Diagnostics and Personalized Treatment: Dream or Reality, 285-304. Nova Science Publishers, 2009.
  5. Ambrósio, António F.; Pereira, Paulo; Vaz, José Cunha-. "Diabetic Retinopathy, Inflammation, and Proteasome". In Interaction Between Neurons and Glia in Aging and Disease, 475-502. Springer US, 2007.
    10.1007/978-0-387-70830-0_22

Propriedade Intelectual

Patente
  1. Pereira, Paulo. 2020. "A method for selective loading of proteins into exosomes and products thereof".

Outros

Outra produção
  1. LAMP2A regulates the loading of proteins into exosomes.. 2021. Ferreira, J.V.; da Rosa Soares, A.; Ramalho, J.; Carvalho, C.M.; Cardoso, M.H.; Pintado, P.; Carvalho, A.S.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85113107544&partnerID=MN8TOARS.
    10.1101/2021.07.26.453637
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/03 LAMP2A and specific peptide motifs regulate the loading of proteins into exosomes. Extracellular vesicles: friends and foes II.
Weizmann Institute (Rehovot, Israel)
2020 2020-2022 More than 200 oral presentations in national and international conferences and symposia

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018 - Atual Engineered exossomes as putative therapeutic tools in Age-related macular degeneration
Orientador
2018 - Atual T cell differentiation as a core component of multiple sclerosis pathogenesis
Orientador
2013 - Atual Implications of HIF1A selective loading in exosomes in Age-Related Macular Degeneration
Orientador
 Post Doc (Outra)
2016 - 2021 Deadly delivery: unravelling the contribution of microglial exosomes to retinal degeneration in glaucoma
Orientador
2018 - 2020 Mechanisms Underlying Exosomal Trafficking of the Antiretroviral Factor APOBEC3G: Implications for the Containment and Eradication of HIV-1 Infection
Orientador
2014 - 2019 A new mechanism for selective protein loading into exosomes
Orientador
2010 - 2016 Identification of the biological pathways and molecular players involved in pulmonary hypertension associated with mir-424
Orientador
2011 - 2015 Integrated multisensory approach to Usher Syndrome: from the genotype to a better characterization of the phenotype
Orientador
2010 - 2015 Unravelling molecular events leading to HIF-1a degradation and endothelial dysfunction in diabetic retinopathy
Orientador
2010 - 2015 Hypoxia and tumorigenesis in colo-rectal cancer: The role of chaperone mediated autophagy in degradation of HIF-1alpha
Orientador
2008 - 2013 HIF & CHIPs A new autophagic pathway for the degradation Hif-1a
Orientador
2008 - 2012 Diabetic microvascular dysfunction: The role of methylglyoxal-induced glycation
Orientador
2007 - 2012 HIF & CHIPs: a new autophagic pathway for the degradation of HIF-1alpha
Orientador
2011 - 2011 Role of HIF1A in cell dysfunction in diabetes
Orientador
 Post Doc (Outra)
2010 - 2011 Tumorigenesis as a working model for the physiological role of HIF-1alpha degradation by Chaperone-Mediated Autophagy
Coorientador
2010 - 2011 A new mechanism for the regulation of intercellular communication through gap-junctions
Orientador
 Post Doc (Outra)
2010 - 2011 Role of E-Cadherin and protein quality control in gastric cancer
Orientador
 Post Doc (Outra)
2010 - 2011 Glaucoma genetics
Orientador
 Post Doc (Outra)
2008 - 2011 Effect of proteasome inhbition on MPP-induced neurotoxicity. Role of GSTP
Orientador
2006 - 2011 Regulation of intercellular communication through connexin 43 degradation: implications in diabetic retinopathy
Orientador
2007 - 2010 Mecanismos de regulação da actividade do proteassoma em condições de excitotoxicidade
Orientador
 Post-Doc (Outra)
2005 - 2010 A new mechanism for regulating intercellular communication through gap-junctions
Orientador
2005 - 2010 Molecular mechanisms regulating muscular atrophy
Orientador
2005 - 2010 What Hif? A new breath for cell dysfunction in diabetes
Orientador
2005 - 2010 Mind the gap: a new molecular model for the intracellular trafficking of connexin 43
Orientador
2004 - 2010 Implications of telomerase activity in tumor development
Orientador
2005 - 2009 Implications of VEGF production in neovascularization associated with diabetic retinopathy: implications of the ubiquitin-proteasome pathway
Orientador
2000 - 2007 Oxidative modifications and protein degradation through the ubiquitin-proteasome pathway
Orientador
2005 - 2006 Intercellular communication and Cx43 degradation in lens and retina
Orientador
1998 - 2003 Functional implications of cholesterol oxidation in the formation of cataracts
Orientador
2000 - 2002 Markers of oxidative damage in diabetes and retinopathy progression
Orientador
1996 - 1998 Cholesterol oxidation in the formation of cataracts
Orientador
1995 - 1997 Experimental models for evaluation of oxidative damage in lens membranes
Orientador

Membro de associação

Nome da associação Tipo de participação
2012 - 2015 JRC-Joint Research Center of the European Union Member of the general assembly
2009 - 2011 Office for Graduate Studies, Faculty of Medicine, University of Coimbra Member of the Office for Graduate Studies, Faculty of Medicine, University of Coimbra
2001 - 2004 Member of GAI - Office for Scientific Research, University of Coimbra

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2012 - 2015 Member of the Board of Directors of the Portuguese Foundation for Science and Technology (FCT)
Diretor
 Fundação para a Ciência e a Tecnologia, Portugal
2009 - 2012 Member of the Scientific Council of the Faculty of Medicine, University of Coimbra
Outro
 Universidade de Coimbra Faculdade de Medicina, Portugal
2009 - 2011 Member of the Scientific Board of the Doctoral Programme in Health Sciences, Faculty of Medicine, University of Coimbra Universidade de Coimbra Faculdade de Medicina, Portugal
2009 - 2011 Member of Board of Directors of Inter-University Doctoral Programme in Ageing and Degeneration of Complex Biological Systems - Doctoral Programme in Health Sciences, Faculty of Medicine, University of Coimbra
Diretor
 Universidade de Coimbra Faculdade de Medicina, Portugal
2007 - 2009 Member of Board of Directors Faculty of Medicine, University of Coimbra
Diretor
 Universidade de Coimbra Faculdade de Medicina, Portugal
Distinções

Prémio

2022 Pedagogic innovation – Blended Learning Award
Universidad Autónoma de Madrid, Espanha

Università degli Studi di Roma Tor Vergata, Itália

Universidade Nova de Lisboa, Portugal
1992 PhD Fellowship UCL

Outra distinção

2006 Fulbright Scholars and Researchers program award