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Anne-Valerie Gendrel obtained her PhD degree from University Paris Sud (Paris, France) in 2005, under the supervision of Dr. Vincent Colot, working on the epigenetic control of transposons in the model plant Arabidopsis thaliana. She then joined the group of Prof. Neil Brockdorff at the MRC-Clinical Sciences Centre in London (UK) for a first postdoc (2005-2009), with an EMBO and then a HFSP postdoctoral fellowship, to investigate the role of DNA methylation in X-chromosome inactivation and monoallelic expression of autosomal genes in the mouse genome. She then moved back to France joining the group of Prof. Edith Heard in the Institut Curie in Paris (France), to develop and supervise a novel project aimed at identifying new genes expressed in random monoallelic fashion on autosomes in the mouse genome and their role in development and disease. In October 2014, she obtained a competitive research position (chargé de recherche) with Inserm in the group of Prof Edith Heard, where she started developing functional approaches to unravel the role of transposable elements in genome regulation during development and in disease contexts. In 2019, she under-took a one-year sabbatical in Instituto de Medicina Molecular (iMM, Lisbon, Portugal) and she was recently awarded with an FCT investigator position to carry on her research projects in iMM (2021-2026). She has so far published 24 articles in international peer review journals with an accumulated impact factor of 362, with over 2700 citations and a h-index of 17 (source Scopus) and 1 article deposited on the bioRxiv preprint server. This includes 5 first author research articles in Nature (Impact Factor - IF: 41.577), Science (IF: 41.058), Developmental cell (IF: 9.616) and Molecular & cellular biology (IF: 3.813), 4 first author review articles, including one in Annual Reviews in Developmental Biology (IF: 9.032), one first author method article in Nature methods (IF: 26.919) and 7 articles as corresponding author. She supervised over 13 students and research technicians since 2014. She has been involved in teaching and was an examiner in various evaluation committees, including PhD defenses. Finally, she has been acting as a ad hoc scientific peer reviewer for various journals and a consultant for projects submitted to the European Commission.
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Identificação

Identificação pessoal

Nome completo
Anne-Valerie GENDREL

Nomes de citação

  • Gendrel, Anne-Valerie

Identificadores de autor

Ciência ID
1917-59ED-F318

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Genética e Hereditariedade
  • Ciências Naturais - Ciências Biológicas - Biologia do Desenvolvimento

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Francês (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador independente (B1) Utilizador elementar (A2) Utilizador elementar (A1) Utilizador independente (B2) Utilizador elementar (A2)
Espanhol; Castelhano Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A1)
Formação
Grau Classificação
2002/01/01 - 2005/02/18
Concluído
 Thèse de doctorat en sciences biologiques, génétique (Doctorat)
Especialização em Molecular Biology
Université Paris-Sud Faculté des Sciences d'Orsay, França
"Epigenetic control of transposable elements in the model plant system Arabidopsis thaliana, and its impact on gene expression" (TESE/DISSERTAÇÃO)
 Mention Tres Honorable
2000/10/01 - 2001/09/05
Concluído
 DEA de Génétique (DEA)
Université Paris VII Denis Diderot UFR Sciences du Vivant, França
"Experimental validation of the use of chromosomal microarrays in the model plant Arabidopsis thaliana" (TESE/DISSERTAÇÃO)
1998/10/01 - 2001/09/05
Concluído
 Magistère de Génétique (Magister (2.º ciclo de estudos))
Université Paris VII Denis Diderot UFR Sciences du Vivant, França
 Mention très bien
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/10/01 - Atual Investigador Auxiliar (carreira) (Investigação) Gulbenkian Institute for Molecular Medicine, Portugal
Gulbenkian Institute for Molecular Medicine, Portugal
2020/12/15 - 2024/09/30 Investigador Auxiliar (carreira) (Investigação) Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019/11/01 - 2020/12/15 Investigador visitante (Investigação) Instituto de Medicina Molecular João Lobo Antunes, Portugal
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2014/10/01 - 2019/11/01 Investigador (Investigação) INSERM Délégation régionale Paris 6, França
Institut Curie Centre de Recherche, França
2009/10/01 - 2014/09/30 Pós-doutorado (Investigação) Institut Curie, França
Institut Curie Centre de Recherche, França
2006/05/01 - 2009/04/01 Pós-doutorado (Investigação) Medical Research Council, Reino Unido
Projetos

Bolsa

Designação Financiadores
2010/01/01 - 2014/03/01 Epigenetic regulation of random monoallelic gene expression during development and in disease
250367
Bolseiro de Pós-Doutoramento
Institut Curie, França
 European Research Council
Concluído
2006/05/01 - 2010/09/01 Role of the SmcHD1 protein on X chromosome inactivation and transposable element silencing
HFSP LT00553/2006-L
Bolseiro de Pós-Doutoramento
Medical Research Council - Clinical Sciences Centre, Reino Unido

Institut Curie Centre de Recherche, França

Human Frontier Science Program, França
Human Frontier Science Program
Concluído
2005/07/01 - 2006/05/01 The role of LINE transposable elements on X-chromosome inactivation
EMBO ALTF 176-2005
Bolseiro de Pós-Doutoramento
Medical Research Council - Clinical Sciences Centre, Reino Unido

European Molecular Biology Organisation, Alemanha
European Molecular Biology Organisation
Concluído

Projeto

Designação Financiadores
2025/03/01 - Atual CRISPR-based genome-wide screens for new regulators of LINE-1 elements activity
2023.13706.PEX
Investigador responsável
Gulbenkian Institute for Molecular Medicine, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2024/10/01 - Atual BIOMICS: Fostering Excellent Research, Training and Innovation in Biomedical Data Science
101159926
Investigador
Gulbenkian Institute for Molecular Medicine, Portugal

European Commission, Bélgica
European Commission
Em curso
2023/03/01 - Atual New horizons for Rett syndrome: exploring the role of transposable elements using genetically engineered human stem cell models
2022.02195.PTDC
Investigador responsável
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2023/02/15 - Atual Dissecting the molecular mechanisms of X-chromosome inactivation using embryonic stem cells
2022.01532.PTDC
Investigador
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/12/15 - Atual Unravelling the extent and the mechanisms by which L1 retrotransposons can influence genome function and stability
10.54499/CEECIND/02085/2018/CP1543/CT0008
Investigador responsável
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Gulbenkian Institute for Molecular Medicine, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2024/12/31 Decoding the Role of DNA Break-Induced Transcription in Ageing
PTDC/MED-OUT/4301/2020
Investigador
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2023/12/31 X-chromosome Inactivation in Systemic Lupus Erythematosus
EXPL/MED-OUT/1517/2021
Investigador
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2021/12/01 - 2023/12/01 Exploring the contribution of transposable elements for the pathogenesis of Rett syndrome
3909
Investigador responsável
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Rettsyndrome.org
Em curso
2016/06/01 - 2019/09/30 Functional analysis of the role of LINE-1 retrotransposons in X-chromosome inactivation
671027
Investigador
Institut Curie, França

INSERM Délégation régionale Paris 6, França
European Research Council

INSERM
Concluído
2008/04/01 - 2009/04/17 Function of structural-maintenance-of chromosome hinge domain containing protein 1 (Smchd1) in X-chromosome inactivation and autosomal gene regulation.
081385
Bolseiro de Pós-Doutoramento
Medical Research Council - Clinical Sciences Centre, Reino Unido

University of Oxford Department of Biochemistry, Reino Unido
Wellcome Trust
Concluído
Produções

Publicações

Artigo em jornal
  1. Yves Deveaux; GENDREL, ANNE-VALERIE; Vincent Colot. "Interférence ARN et contrôle chromatinien de l'activité du génome", BioFutur, 2004
Artigo em revista
  1. Anne-Valerie Gendrel. "The LINE-1 paradox: Active yet immobile". BioEssays (2024): https://doi.org/10.1002/bies.202400256.
    Publicado • 10.1002/bies.202400256
  2. Le Breton, Anna; Bettencourt, Margarida P.; Gendrel, Anne-Valerie. "Navigating the brain and aging: exploring the impact of transposable elements from health to disease". Frontiers in Cell and Developmental Biology 12 (2024): http://dx.doi.org/10.3389/fcell.2024.1357576.
    10.3389/fcell.2024.1357576
  3. Maria Arez; Melanie Eckersley-Maslin; Tajda Klobucar; João von Gilsa Lopes; Felix Krueger; Annalisa Mupo; Ana Cláudia Raposo; et al. "Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation". Nature Communications (2022): https://doi.org/10.1038/s41467-022-33013-5.
    10.1038/s41467-022-33013-5
  4. Ana Cláudia Raposo; Miguel Casanova; Anne-Valerie Gendrel; Simão Teixeira da Rocha. "The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation". Biochemical Society Transactions (2021): https://doi.org/10.1042/BST20210253.
    10.1042/BST20210253
  5. Vasco M Barreto; Kubasova, Nadiya; Clara F Alves-Pereira; GENDREL, ANNE-VALERIE. Autor correspondente: GENDREL, ANNE-VALERIE. "X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as 'Faux Amis'". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.740937.
    Acesso aberto • Publicado • 10.3389/fcell.2021.740937
  6. Marion-Poll, Lucile; Forêt, Benjamin; Zielinski, Dina; Massip, Florian; Attia, Mikael; Carter, Ava C.; Syx, Laurène; et al. Autor correspondente: Gendrel, Anne-Valerie. "Locus specific epigenetic modalities of random allelic expression imbalance". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-25630-3.
    Publicado • 10.1038/s41467-021-25630-3
  7. da Rocha, Simão Teixeira; Gendrel, Anne-Valerie. "The influence of DNA methylation on monoallelic expression". Essays in Biochemistry 63 6 (2019): 663-676. http://dx.doi.org/10.1042/ebc20190034.
    10.1042/ebc20190034
  8. Xu J; Carter AC; Gendrel AV; Attia M; Loftus J; Greenleaf WJ; Tibshirani R; Heard E; Chang HY. "Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells.". (2017): http://europepmc.org/abstract/med/28112738.
    10.1038/ng.3769
  9. Gendrel AV; Marion-Poll L; Katoh K; Heard E. "Random monoallelic expression of genes on autosomes: Parallels with X-chromosome inactivation.". (2016): http://europepmc.org/abstract/med/27101886.
    10.1016/j.semcdb.2016.04.007
  10. Brideau NJ; Coker H; Gendrel AV; Siebert CA; Bezstarosti K; Demmers J; Poot RA; Nesterova TB; Brockdorff N. "Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome.". (2015): http://europepmc.org/abstract/med/26391951.
    10.1128/mcb.00432-15
  11. Gendrel AV; Attia M; Chen CJ; Diabangouaya P; Servant N; Barillot E; Heard E. "Developmental dynamics and disease potential of random monoallelic gene expression.". (2014): http://europepmc.org/abstract/med/24576422.
    10.1016/j.devcel.2014.01.016
  12. Gendrel AV; Heard E. "Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation.". (2014): http://europepmc.org/abstract/med/25000994.
    10.1146/annurev-cellbio-101512-122415
  13. Chelmicki T; Dündar F; Turley MJ; Khanam T; Aktas T; Ramírez F; Gendrel AV; et al. "MOF-associated complexes ensure stem cell identity and Xist repression.". (2014): http://europepmc.org/abstract/med/24842875.
    10.7554/elife.02024
  14. Gendrel AV; Tang YA; Suzuki M; Godwin J; Nesterova TB; Greally JM; Heard E; Brockdorff N. "Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.". (2013): http://europepmc.org/abstract/med/23754746.
    10.1128/mcb.00145-13
  15. Corbel C; Diabangouaya P; Gendrel AV; Chow JC; Heard E. "Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells.". (2013): http://europepmc.org/abstract/med/23362347.
    10.1242/dev.087429
  16. Gendrel AV; Apedaile A; Coker H; Termanis A; Zvetkova I; Godwin J; Tang YA; et al. "Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.". (2012): http://europepmc.org/abstract/med/22841499.
    10.1016/j.devcel.2012.06.011
  17. Gendrel AV; Heard E. "Fifty years of X-inactivation research.". (2011): http://europepmc.org/abstract/med/22069183.
    10.1242/dev.068320
  18. Blewitt ME; Gendrel AV; Pang Z; Sparrow DB; Whitelaw N; Craig JM; Apedaile A; et al. "SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation.". (2008): http://europepmc.org/abstract/med/18425126.
    10.1038/ng.142
  19. Gendrel AV; Colot V. "Arabidopsis epigenetics: when RNA meets chromatin.". (2005): http://europepmc.org/abstract/med/15752993.
    10.1016/j.pbi.2005.01.007
  20. Gendrel AV; Lippman Z; Martienssen R; Colot V. "Profiling histone modification patterns in plants using genomic tiling microarrays.". (2005): http://europepmc.org/abstract/med/16163802.
    10.1038/nmeth0305-213
  21. Lippman Z; Gendrel AV; Colot V; Martienssen R. "Profiling DNA methylation patterns using genomic tiling microarrays.". (2005): http://europepmc.org/abstract/med/16163803.
    10.1038/nmeth0305-219
  22. Lippman Z; Gendrel AV; Black M; Vaughn MW; Dedhia N; McCombie WR; Lavine K; et al. "Role of transposable elements in heterochromatin and epigenetic control.". (2004): http://europepmc.org/abstract/med/15269773.
    10.1038/nature02651
  23. Mathieu O; Jasencakova Z; Vaillant I; Gendrel AV; Colot V; Schubert I; Tourmente S. "Changes in 5S rDNA chromatin organization and transcription during heterochromatin establishment in Arabidopsis.". (2003): http://europepmc.org/abstract/med/14630972.
    10.1105/tpc.017467
  24. Gendrel AV; Lippman Z; Yordan C; Colot V; Martienssen RA. "Dependence of heterochromatic histone H3 methylation patterns on the Arabidopsis gene DDM1.". (2002): http://europepmc.org/abstract/med/12077425.
    10.1126/science.1074950
Capítulo de livro
  1. GENDREL, ANNE-VALERIE. "Transposable elements, RNA interference, and the origin of heterochromatin". In RNAi: A Guide to Gene Silencing, editado por Gregory J. Hannon, 129-148. Cold Spring Harbor, Estados Unidos: CSHL press, 2003.
    Publicado
Pré-impressão
  1. Pérez-Rico, Yuvia A; Bousard, Aurélie; Misikova, Lenka Henao; Mulugeta, Eskeatnaf; de Almeida, Sérgio F; Muotri, Alysson R; Heard, Edith; Gendrel, Anne-Valerie. "Transcriptional perturbation of LINE-1 elements reveals their cis-regulatory potential". 2024. http://dx.doi.org/10.1101/2024.02.20.581275.
    10.1101/2024.02.20.581275
  2. Arez, Maria; Eckersley-Maslin, Melanie; Klobucar, Tajda; von Gilsa Lopes, João; Krueger, Felix; Raposo, Ana Cláudia; Gendrel, Anne-Valerie; de Jesus, Bruno Bernardes; da Rocha, Simão Teixeira. "Sex of donor cell and reprogramming conditions predict the extent and nature of imprinting defects in mouse iPSCs". 2020. http://dx.doi.org/10.1101/2020.11.20.370973.
    10.1101/2020.11.20.370973
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/05/23 Evaluating the cis-regulatory potential of full-length LINE-1 elements. Seminar invitation from Dr. Philippe Arnaud.
Institute of Genetics, Reproduction and Development (iGReD) ( Clermont-Ferrand, França)
2022/10/19 Evaluating the cis-regulatory potential of full-length LINE-1 elements EpIC conference - EpiGene3Sys meets INC-Spain to ChromDesign the Genome
Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica (GENYO) (Granada, Espanha)
2021/05/31 Regulation of monoallelic expression: beyond X-chromosome inactivation Invited lecture for Institute of Genetics and Biophysics
Institute of Genetics and Biophysics (Naples, Itália)
2017/09/19 Regulation of monoallelic gene expression: X-chromosome inactivation and beyond CBI call for recruitment of group leaders
Centre de Biologie Integrative (Toulouse, França)
2016/10/11 Exploring the regulation of LINE-1 elements and their role in X inactivation and gene expression in the mouse IGFL call for group leaders
Institut de Génomique Fonctionnelle de Lyon, France (Lyon, França)
2015/11/15 Autosomal Random Monoallelic Gene Expression in Development and Disease SyBoSS (Systems Biology of Stem Cells and Reprogramming) consortium final meeting
(PARIS, França)
2015/06/01 The developmental dynamics and disease potential of random monoallelic expression Invitation from Dr. Eric Gilson
Institute of Research cancer and aging in Nice (IRCAN) (Nice, França)
2015/05/27 Investigating the dynamics and mechanisms underlying random monoallelic expression during development Invitation from Dr. Pierre-Olivier Couraud
Institut Cochin (Paris, França)
2014/05/13 The developmental dynamics and disease potential of random monoallelic expression Invitation from Dr. Robert Feil
Institut de Génétique Moléculaire de Montpellier (IGMM) (Montpellier, França)
2013/05 Random monoallelic expression in development and disease Colloque “Epigenetic Mechanisms and Genetic Disease”
Collège de France (Paris, França)
2011/09 Smchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome ICC meeting on Imprinting and beyond: monoallelic regulation in health and disease
(Barcelona, Espanha)
2011/07 Smchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome 50 Years of X-inactivation Research
EMBO Workshop (Oxford, Reino Unido)
2010/01/29 Investigating the function of the Smchd1 protein, a new regulator of epigenetic gene silencing Epigenome NoE Workshop, X inactivation and imprinting
(Emmetten, Suiça)
2005/04/27 Transposable elements, heterochromatin and epigenetic control in Arabidopsis Invitation from Dr. Anton Wutz (EMBO interview)
Research Institute of Molecular Pathology (IMP) (Vienna, Áustria)
2005/03/16 Epigenetic regulation of transposable elements and genome expression in Arabidopsis Invited seminar by Dr. Philippe Arnaud
Institut de Génétique Moléculaire de Montpellier (IGMM) (Montpellier, França)
2004/11/18 Role of transposable elements in heterochromatin and epigenetic control in Arabidopsis Invited seminar by Prof. Ueli Grossniklaus
Institute of Plant Biology, University of Zürich (Zurich, Suiça)
2004/09/10 Transposable elements, heterochromatin and epigenetic control in Arabidopsis Invited seminar by Prof. Neil Brockdorff
MRC - Clinical Sciences Centre (London, Reino Unido)
2004/07 Chromosome wide analysis of transposon-mediated gene regulation in Arabidopsis XIIème colloque Eléments transposables
(Tours, França)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/01/01 - Atual Exploring the impact of LINE-1 transposable elements on mammalian genome regulation
Orientador de Anna Le Breton
 PhD in Biological Sciences from the Lisbon Academic Medical Center (Doutoramento)
Gulbenkian Institute for Molecular Medicine, Portugal
2024/02/05 - 2024/11/21 Development of a CRISPR inactivation system for LINE-1 repression in a Rett Syndrome cellular model
Orientador de Sara Leonor Ferreira de Azevedo
 Master of Science in Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2023/01/10 - 2023/12/31 Functional approaches to investigate the role of LINE-1 elements in the maintenance of X-chromosome inactivation
Orientador de Anna Le Breton
 Research technician (Outra)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2023/02/09 - 2023/11/28 Developing human stem cell models to explore the contribution of transposable elements for the pathophysiology of Rett syndrome
Orientador de Margarida Pinho Gonçalves Bento de Bettencourt
 Master of Science in Biomedical Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021/11/01 - 2022/10/31 Uncovering the role of retrotransposons in the cellular aging process, using a Progeria cell model
Orientador de Pedro Miguel Cordeiro Sousa
 25.º PROGRAMA - EDUCAÇÃO PELA CIÊNCIA (2021/2022) (Mestrado)
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
2022/03/28 - 2022/08/26 Investigating the role of LINE-1 elements on gene expression and X-chromosome inactivation
Orientador de Romane Gulh
 Master 1 in Genetics - Magistere Europeen de Genetique (Mestrado)
Université Paris VII Denis Diderot UFR Sciences du Vivant, França

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021/02/15 - 2021/11/30 Investigating the role of LINE-1 elements in gene expression and genome stability through functional approaches
Orientador de Inês Cardial Mendes Dias
 Mestrado Integrado em Engenharia Biológica (MIEB) - Tecnico Lisboa (Mestrado)
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/02/03 - 2020/11/30 Exploring the impact of LINE-1 retrotransposons activation or repression on gene expression in mouse ES cells
Orientador de Lenka Henao Misiková
 Erasmus MSc student (Mestrado)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2014/10/01 - 2019/04/01 Exploring the mechanims underlying random monoallelic expression during differentiation of mouse ES cells into neural progenitor cells
Coorientador de Benjamin Forêt
 Research technician (Outra)
Institut Curie, França
2017/01/01 - 2017/06/20 Assessing the role of active LINE-1 transcription on X-chromosome inactivation
Orientador de Yann Meheust
 Master 2 student, Ecole Normale Superieure de Lyon (Lyon, France) (Mestrado)
Institut Curie, França
2016/02/15 - 2016/12/31 Developing functional approaches to investigate the role of LINE-1 transposable elements in X-chromosome inactivation in mouse ES cells
Orientador de Valentina Carlini
 Master 2. Erasmus + project Unipharma-Graduates (Italy) (Mestrado)
Institut Curie, França
2015/09/01 - 2016/02/15 Development of functional approaches to explore random monoallelic expression and X-chromosome inactivation during mouse ES cell differentiation
Orientador de Kalliopi Chatzovoulou
 Bachelor student, Erasmus plus placement programme, University of Thessaly (Volos, Greece) (Licenciatura/Bacharelato)
Institut Curie, França
2013/04/01 - 2013/06/01 Exploring the random monoallelic expression of Eya genes genes after differentiation of mouse ES cells into neural progenitor cells
Orientador de Jacques Serizay
 Bachelor, Ecole Normale Superieure de Cachan, Cachan, France (Licenciatura/Bacharelato)
Institut Curie, França
2006/05/01 - 2006/08/01 Smchd1 as a Potential Modulator of Gene Silencing
Orientador de Thomas Spruce
 MRes Biomedical Sciences Degree, MRC, UK (Mestrado)
Medical Research Council - Clinical Sciences Centre, Reino Unido
2005/10/01 - 2005/12/31 Investigating the correlation between L1 density and CpG methylation in X chromosome inactivation
Orientador de Emily Brookes
 MRes Biomedical Sciences Degree, MRC, UK (Mestrado)
Medical Research Council - Clinical Sciences Centre, Reino Unido
2003/02/01 - 2003/05/30 Characterization of the reactivation of genes located on the heterochromatic knob on Arabidospsis thaliana chromosome 4
Orientador de Nathanaël Lemonnier
 Master of Science - Université Denis Diderot (Paris VII) (Mestrado)
Plant Genomics Research Unit - Unité de recherche en Génomique Végétale, França

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2017/01/01 - 2017/04/28 Co-organisation with Edith Heard of the "Transposable Elements and Epigenetic Regulation" symposium (2017/04/28)
Simpósio (Coorganizador)
 Collège de France, França

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023/06/19 - 2023/06/22 Poster presentation: Evaluating the cis-regulatory potential of full-length LINE-1 elements: implications for X-chromosome inactivation.
Conferência
 EMBO workshop: X-chromosome inactivation: New insights on its 60th anniversary, Berlin, Germany.
European Molecular Biology Organisation, Alemanha
2023/06/05 - 2023/06/07 Poster presentation: Exploring the contribution of transposable elements for the pathogenesis of Rett syndrome.
Encontro
 2023 IRSF Rett Syndrome Scientific Meeting
Rettsyndrome.org, Estados Unidos
2022/07/12 - 2022/07/12 RiboMed: Satellite Conference on RNA in Disease
Oficina (workshop)
 RiboMed: Satellite Conference on RNA in Disease
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019/06/07 - 2019/06/07 Oral presentation for the general public - festival 'Nuit Sciences et Lettres'. Au-delà du déterminisme génétique: variabilité du vivant et diversité permis par l’épigénétique.
Festival
 Nuit Sciences et Lettres
École Normale Supérieure, França
2014/08/30 - 2014/09/04 Poster presentation: Developmental Dynamics and Disease Potential of Random Monoallelic Gene Expression.
Conferência
 EMBO-FEBS anniversary conference, Paris, France
European Molecular Biology Organisation, Alemanha

Federation of European Biochemical Societies, Reino Unido
2011/09/21 - 2011/09/23 Poster presentation: Smchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.
Conferência
 ICC on Genomic Imprinting and Beyond
Institut d'Investigació Biomèdica de Bellvitge, Espanha
2008/07/06 - 2008/07/09 Poster presentation: The SmcHD1 protein, a new regulator of epigenetic gene silencing in X-chromosome inactivation
Encontro
 Eight HFSP awardees annual meeting, Berlin, Germany
Human Frontier Science Program, França
2004/05/28 - 2004/06/02 Poster presentation: Chromosome-wide analysis of epigenetic variation in Arabidopsis.
Simpósio
 Cold Spring Harbor Symposium on Epigenetics, NY, USA.
Cold Spring Harbor Laboratory, Estados Unidos
2003/06/19 - 2003/06/22 Poster presentation: Global profiling of transcription and epigenetic marks across a heterochromatic region in Arabidopsis.
Conferência
 First Alan Wolffe EMBO Workshop on Chromatin and Epigenetics, Heidelberg, Germany.
European Molecular Biology Organisation, Alemanha

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/11/21 Exploring transposable elements contribution to Rett Syndrome: Development of a CRISPR inactivation system for LINE-1 repression in a Rett Syndrome cellular model
Orientador
 Sara Leonor Ferreira de Azevedo (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/11/28 Developing human stem cell models to explore the contribution of transposable elements for the pathophysiology of Rett syndrome.
Orientador
 Margarida Pinho Gonçalves Bento de Bettencourt (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/11/23 Exploring the role of the ESCRT-III proteins in response to telomeric replication stress in ALT cancer cells
Arguente principal
 Inês Vaz Fernandes Teixeira Justo (Mestrado)
Universidade Nova de Lisboa, Portugal
2021/12/03 PhD thesis - X chromosome transcriptional activity in humans, from early embryonic stages to adult somatic cells
Arguente
 Louis Chauviere (Doutoramento)
Université de Paris, França
2021/11/30 Establishing cellular models to investigate the role of LINE-1 elements in X-chromosome inactivation and genome stability
Orientador
 Inês Cardial Mendes Dias (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021/06/25 Bachelor internship evaluation - TERRA Transcription Upregulation Effects on Telomere Stability and Cell Proliferation
Arguente principal
 João Pedro Pina Rebelo (Outro)
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa, Portugal
2018/09 Master 1 internship evaluation David Benacom (Mestrado)
École Normale Supérieure, França

Université PSL, França
2017/07/06 PhD thesis - The ICF syndrome and emergent players in DNA methylation and development: when studying a rare genetic disease sheds light on an "old" field
Arguente
 Giacomo Grillo (Doutoramento)
Sorbonne Université, França
2006/05 Assessors of MRes rotation report (MRes Biomedical Sciences Degree, MRC, London, UK)
Vogal
 Matthew Bishop (Mestrado)
Medical Research Council - Clinical Sciences Centre, Reino Unido

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2021/12/15 - Atual Research day - Chair of oral communications' session. 24.º Workshop 'Educação pela Ciência' | Bolsas CHULN/FMUL.
Coordenador
 Universidade de Lisboa Faculdade de Medicina, Portugal
2017/03 - Atual Member of the review board of the Institut Curie - IC-3i PhD Program
Avaliador
 Institut Curie, França Institut Curie
2023/05/09 - 2023/05/12 Evaluation of oral presentations. XVI CAML PhD Students Meeting
Avaliador
 Centro Académico de Medicina de Lisboa, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2023/03 - 2023/03 Evaluation of candidates for the 2023 João Lobo Antunes Merit PhD Thesis Award
Avaliador
 Instituto de Medicina Molecular João Lobo Antunes, Portugal
2022/05/04 - 2022/05/06 Evaluation of oral presentations. XV CAML - V NeurUlisboa PhD Students Meeting
Avaliador
 Centro Académico de Medicina de Lisboa, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021/10/15 - 2021/11/15 Evaluation of the applications to the Programa 'Educação pela Ciência' | Bolsas CHULN/FMUL 2021-2022
Avaliador
 Universidade de Lisboa Faculdade de Medicina, Portugal
2021/05/05 - 2021/05/07 Evaluation of oral presentations. XIV CAML - IV NeurUlisboa PhD Students Virtual Meeting.
Avaliador
 Universidade de Lisboa Faculdade de Medicina, Portugal

Centro Académico de Medicina de Lisboa, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2024/10/05 - 2024/11/21 Expert for HORIZON-MSCA-2024-PF-01 postdoctoral fellowships European Commission Marie Sklodowska-Curie Actions, Bélgica
2023/10/05 - 2023/12/08 Expert for HORIZON-MSCA-2023-PF-01 postdoctoral fellowships European Commission Marie Sklodowska-Curie Actions, Bélgica
2022/10/07 - 2022/12/05 Expert for HORIZON-MSCA-2022-PF-01 postdoctoral fellowships European Commission Marie Sklodowska-Curie Actions, Bélgica
2021/11/05 - 2021/12/20 Expert for HORIZON-MSCA-2021-PF-01 postdoctoral fellowships European Commission Marie Sklodowska-Curie Actions, Bélgica
2020/10/01 - 2020/11/10 Expert for H2020-MSCA-IF-2020 postdoctoral fellowships European Commission Marie Sklodowska-Curie Actions, Bélgica
2015/02/01 - 2015/05/29 Expert for European Commission FP7 European Commission Seventh Framework Programme for Research and Technological Development, Bélgica

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2015/11/15 - Atual Magistère européen de Génétique Epigenetics (Magister (2.º ciclo de estudos)) Université Paris VII Denis Diderot UFR Sciences du Vivant, França

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2025/01/01 - Atual Genome Biology and Evolution (1759-6653) Oxford University Press
2024/06/01 - Atual BioEssays (1521-1878) Wiley
2024/01/02 - Atual Epigenomes MDPI
2022/05/01 - Atual Frontiers in Genetics (1664-8021) Frontiers Media
2022/01 - Atual Communications biology (2399-3642) Nature Portfolio
2021/07 - Atual G3 Genes, Genomes, Genetics (2160-1836) Genetics Society of America
2020/09 - Atual Nature Communications (2041-1723) Nature Portfolio
2020/08 - Atual Trends in Genetics (1362-4555) Cell Press
2020/08 - Atual FEBS letter (1873-3468) FEBS Press
2018/04 - Atual eLife (2050-084X) eLife Sciences Publications Ltd
2017 - Atual Philosophical Transactions of the Royal Society B Biological Sciences (1471-2970) The Royal Society
2016 - Atual Genes MDPI
2016 - Atual Cell Reports (2211-1247) Cell Press
2015 - Atual Genome Research (1088-9051) Cold Spring Harbor Laboratory Press
2013 - Atual PLoS ONE (1932-6203) Public Library of Science
Distinções

Outra distinção

2020 FCT Stimulus of Scientific Employment, Individual Support - Assistant Researcher
Fundação para a Ciência e a Tecnologia, Portugal
2014 INSERM researcher position (permanent)
INSERM Délégation régionale Paris 6, França
2007 HFSP Post-doctoral Fellowship
Human Frontier Science Program, França
2006 EMBO Post-doctoral Fellowship
European Molecular Biology Laboratory, Alemanha
2004 Fellowship 'fin de thèse' from Fondation Recherche Medicale
Fondation pour la Recherche Médicale, França
2001 PhD fellowship
Gouvernement francais Ministere de l'education nationale, França