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Paulo Manuel Leal Filipe has developed efforts in the pathophysiology and mechanisms of cutaneous diseases. Skin is ideal organ for developing experimental models as it can be easily inspected and accessed. The focusing in newer insights into mechanisms of cutaneous diseases and of therapies directed to skin. The expertise achieved paved the way to new approaches in the pathogenesis of skin diseases, including psoriasis, such as proteomics, genomics, inflammation and oxidative stress. The main areas of research are: 1) Psoriasis: combining vascular, genetic, inflammation, oxidative stress and proteomic approaches to search for new biomarkers of disease severity and response to various treatments. 2) Vitiligo: insights into bulge derived melanocytes as a repigmentation strategy. role of Phtotherapies.
Identificação

Identificação pessoal

Nome completo
Paulo Manuel Leal Filipe

Nomes de citação

  • Filipe, Paulo

Identificadores de autor

Ciência ID
171A-309C-C397
ORCID iD
0000-0002-7337-6493

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2007 - 2008
Concluído
Management of Health Units (Pós-Graduação)
Universidade Católica Portuguesa Centro de Investigação Interdisciplinar em Saúde, Portugal
2005
Concluído
Medicina (Doutoramento)
Especialização em Dermatology and Venereology; Skin Biology and Pharmacology
Universidade de Lisboa Faculdade de Medicina, Portugal

Université de Paris, França
"Sur les mécanismes moléculaires de l’action des flavonoïdes lors d’un stress oxydant ou photooxydant" (TESE/DISSERTAÇÃO)
Distinção e Louvor, com a classificação numérica d
2002
Concluído
Provas de Aptidão Pedagógica (Outros)
Especialização em Dermatology
Universidade de Lisboa Faculdade de Medicina, Portugal
Muito Bom (unanimidade)
1996
Concluído
Medicina (Título de especialista)
Especialização em Dermatology and Venereology
Universidade de Lisboa Faculdade de Medicina, Portugal
19.1/20
1988
Concluído
Medicina (Licenciatura)
Universidade de Lisboa Faculdade de Medicina, Portugal
16.36
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2016 - 2018 Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa, Portugal
2013 - 2016 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2016 - Atual Chair of Dermatology Department, Hospital de Santa Maria, Lisbon, Portugal Hospital de Santa Maria, Portugal
2014 - Atual Coordinator of the Sub-Committee for Technical Advisory on Dressings and Similar Devices of the Hospital Center Lisbon North Hospital de Santa Maria, Portugal
2014 - Atual President of the eDermatology Portal Committee of Fondation René Touraine Fondation René Touraine, França
2010 - Atual Member of the Commission for Drug Evaluation of INFARMED Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2013/09/01 - Atual Group Leader - Dermatology Research Unit Instituto de Medicina Molecular João Lobo Antunes, Portugal
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2010/09/01 - Atual Responsible of the Inpatient Unit of the Department of Dermatology Hospital de Santa Maria, Portugal
2006/06/01 - Atual Assistant Professor of Dermatology (Coordinator) and of Pathophysiology (Coordinator) Universidade de Lisboa Faculdade de Medicina, Portugal
2005/09/01 - Atual Coordinator of the Photodermatology Unit and of the Psoriasis outpatient Consultation Hospital de Santa Maria, Portugal
Projetos

Bolsa

Designação Financiadores
2008 - 2009 A pele como órgão de monitorização da acumulação de Ferro na hemocromatose
NA
Investigador responsável
Concluído
2006 - 2007 T-cells subsets modulation in psoriatic lesions by photo(chemo)therapy and systemic biological agents.
NA
Investigador responsável
Universidade de Lisboa Faculdade de Medicina, Portugal

Projeto

Designação Financiadores
2008 - Atual Clastogenic plasma factors in psoriatic patients submitted to narrow band UVB phototherapy
NA
Investigador
2007 - 2011 Plasma clastogenic factors before and after biological therapies in plaque psoriasis patients
NA
Investigador
Centre National de la Recherche Scientifique
2005 - 2008 Development of Nuclear Microprobe Techniques for the Quantitative Analysis of Individual Microparticles
Contract nº 13262/R1
Investigador
International Atomic Energy Agency
2004 - 2007 NANODERM: percutaneous uptake of fine and ultrafine particles in bodycare and household products and its impact on human health.
EC/QLKT-CT-2002-02678
Investigador
Concluído
2004 - 2005 In vitro study of the effect of natural and synthetic antioxidants, derived from bioflavonoids in phototoxic lesion induced by some drugs.
NA
Investigador responsável
Concluído
2003 - 2005 Photodynamic therapy in mycosis fungoides /T cells cutaneous lymphoma.
NA
Investigador responsável
Fundação Calouste Gulbenkian
Concluído

Outro

Designação Financiadores
2009 - Atual Influence of Etanercept in the skin and plasma proteomes of psoriatic patients
NA
Investigador responsável
2007 - Atual Influence of Remicade® in the skin proteome of psoriatic patients
NA
Investigador responsável
2007 - Atual Observational Study C0168Z03 – PSOLAR
Investigador
Janssen-Cilag AG
2006 - Atual Genetic and molecular characterization of Portuguese families with generalized pustular psoriasis
NA
Investigador responsável
2013 - 2017 Clinical Trial - CAIN457A2317
Investigador
Novartis Pharmaceuticals
2013 - 2016 Clinical Trial - CAIN457A2312
Investigador
Novartis Pharmaceuticals
2012 - 2015 Clinical Trial - 20120103 - AMAGINE-2
Investigador
Amgen Biofarmaceutica Lda
2011 - 2013 Clinical Trial - A3921080
Investigador
QuintilesIMS

Pfizer Inc
2010 - 2011 Influence of Enbrel in the skin proteome of psoriatic patients
NA
Investigador responsável
Universidade de Lisboa Faculdade de Medicina, Portugal
Concluído
2009 - 2011 Influence of Humira in the skin proteome of psoriatic patients
NA
Investigador responsável
2009 - 2011 Clinical Trial - CNTO1275PSO4004 Janssen-Cilag AG
2004 - 2007 Clinical Trial - EUCTR2004-001236-23-CZ
Investigador responsável
EMD Serono Inc
Produções

Publicações

Artigo em revista
  1. Correia C; Fernandes S; Filipe P. "Subungual Exostosis of the Second Finger.". Actas dermo-sifiliograficas (2024): http://europepmc.org/abstract/med/38340987.
    10.1016/j.ad.2024.02.007
  2. Mancha D; Cunha M; Marques T; de Vasconcelos P; Soares-de-Almeida L; Ferreira J; Filipe P. "Recurrent crops of tender subcutaneous nodules in a 44-year-old man.". Clinical and experimental dermatology (2024): http://europepmc.org/abstract/med/37696776.
    10.1093/ced/llad306
  3. Sun L; Sousa D; de Vasconcelos P; Antunes J; Soares-de-Almeida L; Filipe P. "Generalized hyperpigmented and hypopigmented macules and papules.". Clinical and experimental dermatology (2024): http://europepmc.org/abstract/med/37878587.
    10.1093/ced/llad356
  4. de Sousa D; Volovetska Y; Nunes D; Lemos C; Borges-Costa J; Filipe P. "Clinical and Epidemiological Characteristics of Mpox in HIV-Infected and Uninfected Men Who Have Sex with Men: A Retrospective Study in Lisbon.". Viruses (2024): http://europepmc.org/abstract/med/38400001.
    10.3390/v16020225
  5. Soares I; Amaral IP; Correia MP; Filipe P. "Unusual cutaneous adverse reaction to an erectile dysfunction drug: A case report.". Urology case reports (2023): http://europepmc.org/abstract/med/38173899.
    10.1016/j.eucr.2023.102637
  6. Freitas E; Paiva Lopes MJ; Cruz MJ; Sousa D; Valente AC; Duarte B; Teixeira L; et al. "Real-World Effectiveness and Safety of Baricitinib in Patients with Atopic Dermatitis.". Clinical drug investigation (2023): http://europepmc.org/abstract/med/38114780.
    10.1007/s40261-023-01335-x
  7. Brito Avô L; Pereira L; Oliveira A; Ferreira F; Filipe P; Coelho Rodrigues I; Couto E; et al. "Portuguese Consensus on Acute Porphyrias: Diagnosis, Treatment, Monitoring and Patient Referral.". Acta medica portuguesa (2023): http://europepmc.org/abstract/med/37924314.
    10.20344/amp.20323
  8. Sun L; Alpalhão M; Duarte S; De Vasconcelos P; Sanches M; De-Almeida LS; Filipe P. "Bullous mycosis fungoides with large cell transformation: a fatal outcome following brentuximab treatment.". European journal of dermatology : EJD (2023): http://europepmc.org/abstract/med/38297933.
    10.1684/ejd.2023.4569
  9. Correia C; Fernandes S; Soares-De-Almeida L; Filipe P. "sQUIZ your knowledge! Disseminated mucocutaneous flaccid blisters and tender erosions in a 10-year-old girl.". European journal of dermatology : EJD (2023): http://europepmc.org/abstract/med/38297945.
    10.1684/ejd.2023.4572
  10. Borges V; Duque MP; Martins JV; Vasconcelos P; Ferreira R; Sobral D; Pelerito A; et al. "Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal.". Nature medicine (2023): http://europepmc.org/abstract/med/37696933.
    10.1038/s41591-023-02542-x
  11. Correia C; Soares-de-Almeida L; Filipe P. "Penile Kaposi Sarcoma: The First Manifestation of HIV Infection.". Sexually transmitted diseases (2023): http://europepmc.org/abstract/med/37732842.
    10.1097/olq.0000000000001868
  12. Correia C; Alpalhao M; Soares-de-Almeida L; Filipe P. "Bullous pemphigoid after the second SARS-CoV-2 infection.". Dermatology online journal (2023): http://europepmc.org/abstract/med/37921828.
    10.5070/d329461917
  13. Correia C; Vieitez-Frade J; Filipe P. "New-onset alopecia areata during inclisiran therapy.". Clinical and experimental dermatology (2023): http://europepmc.org/abstract/med/36994830.
    10.1093/ced/llad113
  14. de Sousa D; Filipe P. "Comment on 'Monkeypox: key pointers for dermatologists'.". Clinical and experimental dermatology (2023): http://europepmc.org/abstract/med/36749358.
    10.1093/ced/llad049
  15. Sun L; Brazão C; Mancha D; Soares-de-Almeida L; Tapadinhas C; Filipe P. "Multiple adult xanthogranuloma as the first sign of chronic myelomonocytic leukaemia.". Clinical and experimental dermatology (2023): http://europepmc.org/abstract/med/36785508.
    10.1093/ced/llad056
  16. Correia C; Alpalhão M; de Sousa D; Vieitez-Frade J; Pelerito A; Cordeiro R; Lopes de Carvalho I; et al. "Detection of mpox using polymerase chain reaction from the skin and oropharynx over the course of infection: A prospective study.". Journal of the American Academy of Dermatology (2023): http://europepmc.org/abstract/med/37295504.
    10.1016/j.jaad.2023.05.071
  17. Brazão C; Alpalhão M; Filipe P. "The clinical spectrum of response to narrowband-UVB therapy in chronic plaque psoriasis: The lower limbs are the most difficult-to-treat body region.". Photodermatology, photoimmunology & photomedicine (2023): http://europepmc.org/abstract/med/37127922.
    10.1111/phpp.12877
  18. Brazão C; Fernandes S; Correia T; Filipe P. "Contact allergy to gold from a coffee cup: An unusual source of sensitization.". Contact dermatitis (2023): http://europepmc.org/abstract/med/37204072.
    10.1111/cod.14337
  19. Correia C; Reis M; Filipe P. "Exuberant Plexiform Neurofibroma.". Acta medica portuguesa (2023): http://europepmc.org/abstract/med/37205744.
    10.20344/amp.19477
  20. Mancha D; Filipe P. "Phototherapy in the artificial intelligence era.". Photodermatology, photoimmunology & photomedicine (2023): http://europepmc.org/abstract/med/37259232.
    10.1111/phpp.12890
  21. Patrocinio J; Frade J; Sousa D; Correia C; Filipe P. "Skin picking: the overlooked cutaneous manifestation of Prader-Willi syndrome.". Dermatology online journal (2023): http://europepmc.org/abstract/med/37220300.
    10.5070/d329260784
  22. Brazão C; Mancha D; Soares-de-Almeida L; Filipe P. "Sweet syndrome following SARS-CoV-2 infection: A unique bullous photo-distributed presentation.". Journal of the European Academy of Dermatology and Venereology : JEADV (2023): http://europepmc.org/abstract/med/36912698.
    10.1111/jdv.19038
  23. Correia C; Soares-de-Almeida L; Filipe P. "Exuberant cutaneous metastasis of gastric adenocarcinoma.". Actas dermo-sifiliograficas (2023): http://europepmc.org/abstract/med/36738777.
    10.1016/j.ad.2022.03.036
  24. Correia C; Fernandes S; Correia T; Soares-de-Almeida L; Filipe P. "Varenicline-induced drug eruption: case and review of the literature.". Dermatology online journal (2023): http://europepmc.org/abstract/med/37040914.
    10.5070/d329160217
  25. Correia C; Fernandes S; Filipe P. "Subungual Exostosis of the Second Finger.". Actas dermo-sifiliograficas (2023): http://europepmc.org/abstract/med/36842476.
    10.1016/j.ad.2023.01.007
  26. Brazão C; Filipe P. "sQUIZ your Knowledge! Hyperkeratotic verrucous plaques and nodules and hyperpigmented warts in the setting of Hodgkin lymphoma.". European journal of dermatology : EJD (2023): http://europepmc.org/abstract/med/37178044.
    10.1684/ejd.2023.4439
  27. Peixoto C; Lopes MB; Martins M; Casimiro S; Sobral D; Grosso AR; Abreu C; et al. "Identification of biomarkers predictive of metastasis development in early-stage colorectal cancer using network-based regularization.". BMC bioinformatics (2023): http://europepmc.org/abstract/med/36647008.
    10.1186/s12859-022-05104-z
  28. Frade JV; Sousa I; Marques T; Filipe P. "Acute paronychia: An atypical presentation of Monkeypox infection.". Enfermedades infecciosas y microbiologia clinica (English ed.) (2023): http://europepmc.org/abstract/med/36710164.
    10.1016/j.eimce.2022.09.011
  29. Sun L; Brazão C; Mancha D; Soares-de-Almeida L; Filipe P. "Reply to: 'Severe bullous pemphigoid following Covid-19 vaccination resistant to rituximab and successfully treated with dupilumab' by Baffa et al.". Journal of the European Academy of Dermatology and Venereology : JEADV (2023): http://europepmc.org/abstract/med/36681888.
    10.1111/jdv.18893
  30. Mancha D; Antunes J; Soares-de-Almeida L; Borges-Costa J; Filipe P. "Localized Vitiligo and Post-Inflammatory Hypopigmentation at the Injection Site of a COVID-19 mRNA Vaccine.". Dermatology practical & conceptual (2023): http://europepmc.org/abstract/med/36892365.
    10.5826/dpc.1301a23
  31. Alexandre MI; Garrido PM; Filipe P. "Treatment of Diabetes in Bullous Pemphigoid Patients: Where Do We Stand?". Dermatology practical & conceptual (2023): http://europepmc.org/abstract/med/36892363.
    10.5826/dpc.1301a63
  32. Torres T; Filipe P; Menezes Brandão F; Figueiredo A; Pinto Soares A; Sousa Basto A; Rebelo C; et al. "Epidemiology of Psoriasis in Portugal: A Population-Based Study.". Acta medica portuguesa (2023): http://europepmc.org/abstract/med/36608696.
    10.20344/amp.19048
  33. Correia C; Fernandes S; Soares-de-Almeida L; Filipe P. "Hyperkeratotic Yellow-Brown Papules on the Feet.". Actas dermo-sifiliograficas (2022): http://europepmc.org/abstract/med/36473520.
    10.1016/j.ad.2021.07.033
  34. Mancha D; Brazão C; Filipe P. "Oro-mammary inoculation pathway of monkeypox in a female patient.". Journal of the European Academy of Dermatology and Venereology : JEADV (2022): http://europepmc.org/abstract/med/36264217.
    10.1111/jdv.18672
  35. Alpalhão M; Duarte J; Diogo R; Vandemeulebroecke M; Ortmann CE; Kasparek T; Filipe P. "Lower Limbs are the Most Difficult-to-Treat Body Region of Patients with Psoriasis: Pooled Analysis of CLEAR and CLARITY Studies of Secukinumab Versus Ustekinumab by Body Region.". BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy (2022): http://europepmc.org/abstract/med/36334236.
    10.1007/s40259-022-00558-2
  36. Brazão C; Filipe P. "[Artículo traducido] Datos relativos a los casos de sarna durante la pandemia de COVID-19: análisis bienal realizado en el mayor hospital docente terciario de Portugal The Data on Scabies Cases During COVID-19 Pandemic: A Two-Year Analysis From the Largest Portuguese Tertiary Teaching Hospital". Actas dermo-sifiliograficas (2022): http://europepmc.org/abstract/PMC/PMC9640372.
  37. Sun L; Alpalhão M; Filipe P. "Analysis of dermatology emergency consultations in a pediatric population: One-year retrospective audit from the largest Portuguese tertiary teaching hospital.". Pediatric dermatology (2022): http://europepmc.org/abstract/med/36400486.
    10.1111/pde.15189
  38. Alpalhão M; Botequim D; Ferreira J; Santus R; Filipe P. "Photosensitization of human skin fibroblasts by vemurafenib promotes pleiotropic effects on membrane-enclosed organelles and apoptosis.". Journal of photochemistry and photobiology. B, Biology (2022): http://europepmc.org/abstract/med/36434899.
    10.1016/j.jphotobiol.2022.112600
  39. Queirós C; Garrido PM; Fraga A; Maia-Silva J; Filipe P. "Nail Surgery: General Principles, Fundamental Techniques, and Practical Applications.". Journal of cutaneous and aesthetic surgery (2022): http://europepmc.org/abstract/med/37035605.
    10.4103/jcas.jcas_81_21
  40. Antunes-Duarte S; Marcos-Pinto A; Ferreira J; Soares-de-Almeida L; Filipe P. "Rhinoentomophthoromycosis: A cause of central face disfigurement.". International journal of dermatology (2022): http://europepmc.org/abstract/med/36183330.
    10.1111/ijd.16436
  41. Brazão C; Garrido PM; Alpalhão M; Roda Â; Vieitez-Frade J; Ferreira JA; Pelerito A; et al. "Monkeypox virus infection in HIV-1-coinfected patients previously vaccinated against smallpox: A series of 4 cases from Portugal.". Journal of the European Academy of Dermatology and Venereology : JEADV (2022): http://europepmc.org/abstract/med/36223385.
    10.1111/jdv.18655
  42. Frade JV; Sousa I; Marques T; Filipe P. "Acute paronychia: An atypical presentation of Monkeypox infection.". Enfermedades infecciosas y microbiologia clinica (2022): http://europepmc.org/abstract/med/36320449.
    10.1016/j.eimc.2022.09.003
  43. Alpalhão M; Sousa D; Frade JV; Patrocínio J; Garrido PM; Correia C; Brazão C; et al. "Human immunodeficiency virus infection may be a contributing factor to monkeypox infection: Analysis of a 42-case series.". Journal of the American Academy of Dermatology (2022): http://europepmc.org/abstract/med/36156305.
    10.1016/j.jaad.2022.09.029
  44. de Sousa D; Patrocínio J; Frade J; Brazão C; Mancha D; Correia C; Borges-Costa J; Filipe P. "Monkeypox Diagnosis by Cutaneous and Mucosal Findings.". Infectious disease reports (2022): http://europepmc.org/abstract/med/36286198.
    10.3390/idr14050077
  45. Chakma B; Gomes D; Filipe PA; Soares P; de Sousa B; Nunes C. "A temporal analysis on patient and health service delays in pulmonary tuberculosis in Portugal: inter and intra-regional differences and in(equalities) between gender and age.". BMC public health (2022): http://europepmc.org/abstract/med/36171570.
    10.1186/s12889-022-14216-3
  46. Alpalhão M; Duarte S; Correia I; Filipe P. "Combination treatment of COVID-19 associated herpes zoster scar with 1540 nm and 755 nm picosecond lasers: a case report.". Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology (2022): http://europepmc.org/abstract/med/36067361.
    10.1080/14764172.2022.2120619
  47. Correia C; Soares-de-Almeida L; Filipe P. "Exuberant Cutaneous Metastasis of Gastric Adenocarcinoma.". Actas dermo-sifiliograficas (2022): http://europepmc.org/abstract/med/36075403.
    10.1016/j.ad.2022.03.021
  48. Sobral D; Martins M; Kaplan S; Golkaram M; Salmans M; Khan N; Vijayaraghavan R; et al. "Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development.". Communications biology (2022): http://europepmc.org/abstract/med/36085309.
    10.1038/s42003-022-03884-x
  49. Bouceiro-Mendes R; Ortins-Pina A; Mendonça-Sanches M; Filipe P. "[Artículo traducido] Vasculopatía livedoide asociada a polimorfismos del inhibidor del activador de plasminógeno tipo 1 con inhibidores del factor Xa tratados Livedoid Vasculopathy Associated With Plasminogen Activator Inhibitor-1 Polymorphisms Treated With Factor Xa Inhibitors". Actas dermo-sifiliograficas (2022): http://europepmc.org/abstract/PMC/PMC9359626.
  50. de Sousa D; Frade J; Patrocínio J; Borges-Costa J; Filipe P. "Monkeypox infection and bacterial cellulitis: a complication to look for.". International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (2022): http://europepmc.org/abstract/med/36055636.
    10.1016/j.ijid.2022.08.024
  51. Pupo Correia M; Fernandes S; Filipe P. "Cutaneous adverse reactions to the new oral antiviral drugs against SARS-CoV-2.". Clinical and experimental dermatology (2022): http://europepmc.org/abstract/med/35643856.
    10.1111/ced.15281
  52. de Sousa D; Patrocínio J; Frade J; Correia C; Borges-Costa J; Filipe P. "Human monkeypox coinfection with acute HIV: an exuberant presentation.". International journal of STD & AIDS (2022): http://europepmc.org/abstract/med/35822910.
    10.1177/09564624221114998
  53. Correia C; Fernandes S; Soares-de-Almeida L; Filipe P. "Hyperkeratotic Yellow-Brown Papules on the Feet.". Actas dermo-sifiliograficas (2022): http://europepmc.org/abstract/med/35850233.
    10.1016/j.ad.2021.07.027
  54. Correia C; Antunes J; Filipe P. "Management of acne induced by JAK inhibitors.". Dermatologic therapy (2022): http://europepmc.org/abstract/med/35789037.
    10.1111/dth.15688
  55. Correia C; Soares-de-Almeida L; Filipe P. "[Disseminated Skin Ulcers Associated with Methotrexate].". Acta medica portuguesa (2022): http://europepmc.org/abstract/med/35857386.
    10.20344/amp.18462
  56. Alpalhão M; Frade JV; Sousa D; Patrocínio J; Garrido PM; Correia C; Brazão C; et al. "Monkeypox: a new (sexually transmissible) epidemic?". Journal of the European Academy of Dermatology and Venereology : JEADV (2022): http://europepmc.org/abstract/med/35841292.
    10.1111/jdv.18424
  57. Brazão C; Pimenta R; Queirós C; Filipe P; Menezes Falcão L. "Cutaneous Markers of Cardiovascular Diseases.". Acta medica portuguesa (2022): http://europepmc.org/abstract/med/35723967.
    10.20344/amp.18108
  58. Garrido PM; Aguado-Lobo M; Espinosa-Lara P; Soares-Almeida L; Filipe P. "Association of Peripheral Blood and Cutaneous Eosinophils With Bullous Pemphigoid Disease Severity and Treatment Outcomes.". Actas dermo-sifiliograficas (2022): http://europepmc.org/abstract/med/35659610.
    10.1016/j.ad.2022.05.021
  59. Brazão C; Filipe P. "The Data on Scabies Cases During COVID-19 Pandemic: A Two-Year Analysis From the Largest Portuguese Tertiary Teaching Hospital.". Actas dermo-sifiliograficas (2022): http://europepmc.org/abstract/med/35709953.
    10.1016/j.ad.2022.06.005
  60. Correia C; Borges-Costa J; Soares-de-Almeida L; Filipe P. "Lues Maligna in an Immunocompetent Patient.". Sexually transmitted diseases (2022): http://europepmc.org/abstract/med/35709215.
    10.1097/olq.0000000000001664
  61. Correia C; Ferreira J; Soares-de-Almeida L; Filipe P. "An Unusual Cause of Eumycetoma - Fusarium Solani Keratoplasticum.". Actas dermo-sifiliograficas (2022): http://europepmc.org/abstract/med/35513035.
    10.1016/j.ad.2021.04.013
  62. Correia C; Soares-de-Almeida L; Filipe P. "[Fibrofolliculomas: The Clue to the Diagnosis of Birt-Hogg-Dubé Syndrome].". Acta medica portuguesa (2022): http://europepmc.org/abstract/med/35523128.
    10.20344/amp.17339
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  227. André, Marisa C.; Silva, Raquel; Filipe, Paulo L.; Lopes, Anabela; Soares de Almeida, L.M.. "Systemic contact allergy to penicillin after prick and intradermal tests". Annals of Allergy, Asthma & Immunology 106 2 (2011): 174-175. http://dx.doi.org/10.1016/j.anai.2010.11.017.
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  275. Filipe P; Emerit I; Vassy J; Levy A; Huang V; Freitas J. "Cellular penetration of fluorescently labeled superoxide dismutases of various origins.". Molecular medicine (Cambridge, Mass.) (1999): http://europepmc.org/abstract/med/10501655.
    10.1007/bf03401979
  276. Silva JM; Filipe PM; Fernandes AC; Manso CF. "[Antioxidant effect of drugs used in cardiovascular therapy].". Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology (1998): http://europepmc.org/abstract/med/9677827.
  277. Freitas, J.P.; Filipe, P.; Yousefi, A.; Emerit, I.; Guerra Rodrigo, F.. "Oxidative Stress in Adamantiades-Behçet’s Disease". Dermatology 197 4 (1998): 343-348. http://dx.doi.org/10.1159/000018029.
    10.1159/000018029
  278. Sarkisian, T.; Emerit, I.; Arutyunyan, R.; Levy, A.; Cernjavski, L.; Filipe, P.. "Familial Mediterranian fever: clastogenic plasma factors correlated with increased O 2 - - production by neutrophils". Human Genetics 101 2 (1997): 238-242. http://dx.doi.org/10.1007/s004390050623.
    10.1007/s004390050623
  279. Filipe, P.; Emerit, I.; Youssefi, A. Alaoui; Levy, A.; Cernjavski, L.; Freitas, J.; Castro, J. L. Cirne. "Oxyradical-mediated Clastogenic Plasma Factors in Psoriasis: Increase in Clastogenic Activity after PUVA". Photochemistry and Photobiology 66 4 (1997): 497-501. http://dx.doi.org/10.1111/j.1751-1097.1997.tb03179.x.
    10.1111/j.1751-1097.1997.tb03179.x
  280. Filipe P; Emerit I; Vassy J; Rigaut JP; Martin E; Freitas J; Fernandes A. "Epidermal localization and protective effects of topically applied superoxide dismutase.". Experimental dermatology (1997): http://europepmc.org/abstract/med/9226133.
    10.1111/j.1600-0625.1997.tb00157.x
  281. Freitas, J.P.; Filipe, P.M.; Rodrigo, F.Guerra. "Lipid peroxidation in type 2 normolipidemic diabetic patients". Diabetes Research and Clinical Practice 36 2 (1997): 71-75. http://dx.doi.org/10.1016/s0168-8227(97)00032-6.
    10.1016/s0168-8227(97)00032-6
  282. Filipe PM; Fernandes AC; Silva JN; Freitas JP; Manso CF. "[Effect of silibinin on oxidative damage of blood constituents]". Comptes rendus des seances de la Societe de biologie et de ses filiales (1997): http://europepmc.org/abstract/med/9587488.
  283. Freitas JP; Filipe P; Guerra Rodrigo F. "[Glycosylation and lipid peroxidation in skin and in plasma in diabetic patients].". Comptes rendus des seances de la Societe de biologie et de ses filiales (1997): http://europepmc.org/abstract/med/9587489.
  284. Emerit, I.; Filipe, P.; Meunier, P.; Auclair, C.; Freitas, J.; Deroussent, A.; Gouyette, A.; Fernandes, A.. "Clastogenic Activity in the Plasma of Scleroderma Patients: A Biomarker of Oxidative Stress". Dermatology 194 2 (1997): 140-146. http://dx.doi.org/10.1159/000246083.
    10.1159/000246083
  285. Emerit, I.; Garban, F.; Vassy, J.; Levy, A.; Filipe, P.; Freitas, J.. "Superoxide-mediated clastogenesis and anticlastogenic effects of exogenous superoxide dismutase". Proceedings of the National Academy of Sciences 93 23 (1996): 12799-12804. http://dx.doi.org/10.1073/pnas.93.23.12799.
    10.1073/pnas.93.23.12799
  286. Silva J; Freitas JP; Filipe P; Vendrell E; Rodrigo FG. "[Fluorescent products in the crystalline lens of type ii diabetic patients]". Acta medica portuguesa (1996): http://europepmc.org/abstract/med/9005703.
  287. Filipe, P.; Soares Almeida, Raquel Silva L.; Rodrigo, F. Guerra. "Occupational allergic contact dermatitis from cephalosporins". Contact Dermatitis 34 3 (1996): 226-226. http://dx.doi.org/10.1111/j.1600-0536.1996.tb02186.x.
    10.1111/j.1600-0536.1996.tb02186.x
  288. Fernandes, Afonso C; Filipe, Paulo M; Freitas, JoÃo P; Manso, Carlos F. "Different effects of thiol and nonthiol ace inhibitors on copper-induced lipid and protein oxidative modification". Free Radical Biology and Medicine 20 4 (1996): 507-514. http://dx.doi.org/10.1016/0891-5849(95)02086-1.
    10.1016/0891-5849(95)02086-1
  289. Freitas, J.P.; Filipe, P.; Emerit, I.; Meunier, P.; Manso, C.F.; Rodrigo, Guerra. "Hyaluronic Acid in Progressive Systemic Sclerosis". Dermatology 192 1 (1996): 46-49. http://dx.doi.org/10.1159/000246314.
    10.1159/000246314
  290. Meunier P; Filipe P; Emerit I; Freitas J; Guerra Rodrigo F; Manso C. "Adenosine deaminase in progressive systemic sclerosis.". Acta dermato-venereologica (1995): http://europepmc.org/abstract/med/8578953.
    10.2340/0001555575297299
  291. Filipe, Paulo Leal; Freitas, João P.; Castro, José Cirne; Silva, Raquel; Rodrigo, Fernando Guerra. "Drug Eruption Induced by Acetaminophen in Infectious Mononucleosis". International Journal of Dermatology 34 3 (1995): 220-221. http://dx.doi.org/10.1111/j.1365-4362.1995.tb01580.x.
    10.1111/j.1365-4362.1995.tb01580.x
  292. Fernandes, A. C.; Filipe, P. M.; Manso, C. F.. "pH dependence of lipid peroxidation and albumin oxidative modification: possible implications to the pH paradox". Redox Report 1 2 (1995): 139-144. http://dx.doi.org/10.1080/13510002.1995.11746972.
    10.1080/13510002.1995.11746972
  293. Freitas, J. P.; Filipe, P. M.. "Pentoxifylline". Biological Trace Element Research 47 1-3 (1995): 307-311. http://dx.doi.org/10.1007/bf02790131.
    10.1007/bf02790131
  294. Filipe, P. M.; Fernandes, A. C.; Manso, C. F.. "Effects of zinc on copper-induced and spontaneous lipid peroxidation". Biological Trace Element Research 47 1-3 (1995): 51-56. http://dx.doi.org/10.1007/bf02790100.
    10.1007/bf02790100
  295. Freitas JP; Filipe P; Guerra Rodrigo F. "[Potential antioxidative effects of pentoxifylline].". Comptes rendus des seances de la Societe de biologie et de ses filiales (1995): http://europepmc.org/abstract/med/8521088.
  296. Filipe PM; Freitas JP; Castro M; Pinto R; Fernandes A; de Castro LC; Rico T; Rodrigo FG. "[Lipid peroxidation, production of PGE2 and cellular mortality induced by UV in cultured human skin fibroblasts]". Comptes rendus des seances de la Societe de biologie et de ses filiales (1995): http://europepmc.org/abstract/med/8521092.
  297. Filipe PM; Fernandes AC. "[Stress proteins].". Acta medica portuguesa (1994): http://europepmc.org/abstract/med/7717118.
  298. Filipe PL; Coutinho VS; Canhão P; Gouveia R; Cabeçadas J; Osório A; Antunes JL; et al. "Mycosis fungoides with early central nervous system involvement.". Acta dermato-venereologica 74 1 (1994): 63-64. http://europepmc.org/abstract/med/7908488.
    10.2340/00015555746364
  299. Filipe PM; Fernandes AC; Saavedra JA; Manso CF. "[Ketanserin as antioxidant].". Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology (1993): http://europepmc.org/abstract/med/8352986.
  300. Fernandes, Afonso C.; Filipe, Paulo M.; Manso, Carlos F.. "Protective effects of a 21-aminosteroid against copper-induced erythrocyte and plasma lipid peroxidation". European Journal of Pharmacology 220 2-3 (1992): 211-216. http://dx.doi.org/10.1016/0014-2999(92)90750-x.
    10.1016/0014-2999(92)90750-x
  301. Fernandes, Afonso C.; Filipe, Paulo M.; Coelho, Helena; Manso, Carlos F.. "The inhibition of lipid peroxidation by cinnarizine possible implications to its therapeutic and side-effects". Biochemical Pharmacology 41 5 (1991): 709-714. http://dx.doi.org/10.1016/0006-2952(91)90070-l.
    10.1016/0006-2952(91)90070-l
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2008 Etanercept – a experiência do Serviço de Dermatologia do HSM 2º Encontro Nacional Wyeth sobre Psoríase
(Óbidos, Portugal)
2007 Lidar com efeitos adversos de agentes biológicos Workshop do 1º Encontro Nacional Wyeth sobre Psoríase
(Vilamoura, Portugal)
2007 A importância de todos na fotoeducação Vantagens e desvantagens da exposição solar – o caso da pele
(Lisboa, Portugal)
2004 Anti-and Prooxidant effects of urate in copper-induced low-density lipoprotein oxidation Réunion Scientifique de la SFRR
(Paris, França)
2004 Fotoimunomodulação SIMPÓSIO – TERAPÊUTICA IMUNOMODULATÓRIA EM DERMATOLOGIA
(Lisboa, Portugal)
2004 Effects of flavonoïds on the oxidative stress induced in cultured skin cells by UVA irridiation or by UVA-photosensitization with cyamemazine Réunion Scientifique de la SFRR
2003 Effects of flavonoids on the UVA-induced phototoxicity in human skin cells Workshop: "Oxidative Stress: molecular and cellular mechanisms; protection by antioxidants"
(Lisboa, Portugal)
2001 Flavonoids and urate antioxidant interplay in plasma oxidative stress Workshop: "Oxidative Stress in Biology and Medicine"
(Lisboa, Portugal)
1999 Stress oxidativo na psoríase. Influência do tratamento com PUVA Simposio: La investigación en Dermatología XIV Congreso Ibero-Latino-Americano de Dermatología
(Malaga, Espanha)
1999 Potential therapeutical applications of superoxide dismutases Conference, Hôpital de Saint-Louis
(Paris, França)
1995 Peroxydation lipidique, production de PGE2 et mortalité cellulaire induites par les UVB dans des fibroblastes cutanés humains en culture Reunion D\'Hiver de la Societé Française de Recherches sur les Radicaux Libres
(Paris, França)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2010 - 2011 Estudo de associação de gravidade do envolvimento ungueal e articular
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2007 - 2011 Étude des effets photosensibilisés de nouvelles molécules de synthèse: applications potentielles en photochimiothérapie antitumoral cutanée
Orientador
Doutoramento em Dermatologia (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal

Université de Picardie Jules Verne Eco PRocédés Optimisation et Aide à la Décision, França
2009 - 2010 Um retrato da psoríase em Portugal. Estudo epidemiológico e clínico de 1021 doentes seguidos em ambulatório
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - 2010 Psoríase do couro cabeludo. Revisão clínica e actualização terapêutica
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - 2010 Pênfigo Vulgar. Revisão Casuística do Serviço de Dermatologia do HSM
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2009 Medicamentos biológicos na psoríase: quando a fisiopatologia contribui para o desenvolvimento terapêutico
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2009 Terapêutica Fotodinâmica em Dermatologia. Casos tratados no Serviço de Dermatologia do Hospital de Santa Maria
Orientador
Universidade de Lisboa Faculdade de Medicina, Portugal
Distinções

Prémio

2006 Prémio Bolsa Serono de Investigação Biomédica em Portugal, Modulação de subpopulações de células T
2005 Prémio para a melhor comunicação “Morbilidade e mortalidade pela corticoterapia no pênfigo"
Sociedade Portuguesa de Dermatologia e Veneorologia, Portugal
2005 Prémio Científico APDF 2005
Sociedade Portuguesa de Doutorados em França, Portugal
2004 Prémio para o melhor caso clínico apresentado em painel ("Necrobiose Lipóidica")
Sociedade Portuguesa de Dermatologia e Veneorologia, Portugal
2001 Prémio atribuído ao melhor caso clínico apresentado ("Sindroma de Papillon-Lefévre")
Sociedade Portuguesa de Dermatologia e Veneorologia, Portugal
1998 Prémio Edol atribuído ao melhor caso clínico apresentado em painel
Sociedade Portuguesa de Dermatologia e Veneorologia, Portugal