Simão José Teixeira da Rocha (1310-8F0F-1387)

Curriculum Vitae

Simão José Teixeira da Rocha

Academic Foundation & Doctoral Training: My scientific career began in 1997 at the University of Porto, where I graduated top of my class in Biology (18/20). Following the GABBA graduate program (2001–2002) under Prof. Maria de Sousa, I moved to the University of Cambridge for a PhD and postdoc in Mammalian Developmental Epigenetics with Prof. Anne Ferguson-Smith. This period yielded nine publications, including four as first author. Postdoctoral & Senior Research: In 2008, I joined Prof. Edith Heard’s lab at Institut Curie (France), focusing on Molecular Epigenetics. This work resulted in nine peer-reviewed articles (three as first author; one as senior/corresponding author) in premier journals including Cell, Molecular Cell, and Nature Structural & Molecular Biology. In 2015, I transitioned to iMM (Lisbon) as a Senior Researcher in Prof. Maria do Carmo Fonseca’s lab, supported by successive iFCT and CEEC Assistant Researcher contracts. There, I secured five grants as PI and published nine articles (five as senior author) in journals such as Nucleic Acids Research and Human Molecular Genetics. Current Appointments & Lab Leadership: Since 2022, I have led the Stem Cell Epigenetics Lab at iBB/IST, University of Lisbon, supported by a second CEEC contract. In April 2024, I was appointed Assistant Professor in Molecular and Cell Biology at IST. My research integrates epigenetics and stem cell biology across three pillars: - Mechanisms of epigenetic gene regulation. - Epigenetic fidelity of stem cell models. - Disease modeling of human developmental disorders. I currently lead a team of 13 researchers (one senior researcher, three postdocs, four PhD students, one research assistant, and three MSc students). Key Performance Indicators: Publications: 45 peer-reviewed articles and book chapters (h-index: 21; 2,855 citations); Authorship: 10 as first author; 20 as senior and corresponding author; Funding: Secured 10 project grants as PI/Co-PI. Currently leading three projects: X-HUMAN (FCT), XCI_REVERSAL (FCT), and STEM_CELL_ANGEL (ASA); Consortia: Work Package Leader Substitute for the European Commission-funded EURAS consortium; Mentorship: Supervised/co-supervised 24 MSc, 8 PhD students and 5 postdocs to date. Summary: With a career spanning top-tier institutions in Portugal, the UK, and France, I am dedicated to advancing the fields of gene regulation and cellular reprogramming through high-impact research and the mentorship of the next generation of scientists.

Ler resumo completo ↓

Identificação

Identificação pessoal

Nome completo: Simão José Teixeira da Rocha

Nomes de citação

da Rocha, Simão T.

Identificadores de autor

Ciência ID: 1310-8F0F-1387
ORCID iD: 0000-0002-9683-7942

Endereços de correio eletrónico

simao.rocha@tecnico.ulisboa.pt (Profissional)
simaoteixeiradarocha@medicina.ulisboa.pt (Profissional)
simaoroc@gmail.com (Pessoal)

Telefones

Telefone

217999411 Ext.: 47320 (Profissional)

Moradas

Av. Rovisco Pais , 1049-001, Lisboa, Lisboa, Portugal (Profissional)
Rua Tomás da Anunciação 161, 4ºESQ, 1350-326, Lisboa, Lisboa, Portugal (Pessoal)

Websites

https://scerg.tecnico.ulisboa.pt/biolengpsclab3.html (Académico)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Francês	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)

Formação

	Grau	Classificação
2002/10/03 - 2007/05/12 Concluído	PhD in Biology (Doutoramento) University of Cambridge Department of Physiology Development and Neuroscience, Reino Unido "The role of Delta-like 1 (Dlk1) in mouse development and metabolism " (TESE/DISSERTAÇÃO)	Approved
2001/11/05 - 2002/06/30 Concluído	GABBA program (Graduation in Basic and Applied Biology) (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	Very Good
1997/09/15 - 2001/07/15 Concluído	Biology (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal "6q chromosome deletions in gastric cancer" (TESE/DISSERTAÇÃO)	18 (out of 20)

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2022/11/15 - Atual	Investigador principal (carreira) (Investigação)	Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
	Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2015/04/01 - 2022/11/14	Investigador (Investigação)	Instituto de Medicina Molecular, Portugal
	Instituto de Medicina Molecular, Portugal
2008/04/01 - 2014/12/31	Pós-doutorado (Investigação)	Institut Curie, França
	Institut Curie, França
2008/05/15 - 2008/08/15	Pós-doutorado (Investigação)	University of Copenhagen Biotech Research and Innovation Centre, Dinamarca
	University of Copenhagen Biotech Research and Innovation Centre, Dinamarca
2007/05/14 - 2008/03/31	Pós-doutorado (Investigação)	University of Cambridge Department of Physiology Development and Neuroscience, Reino Unido
	University of Cambridge Department of Physiology Development and Neuroscience, Reino Unido

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2024/04/01 - Atual	Professor Auxiliar (Docente Universitário)	Universidade de Lisboa Instituto Superior Técnico, Portugal
	Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/09/01 - 2023/08/31	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Lisboa Faculdade de Medicina, Portugal
	Universidade de Lisboa Faculdade de Medicina, Portugal

Projetos

Bolsa

	Designação	Financiadores
2023/06/01 - Atual	Role of microbial metabolites in regulating hypothalamic pathways involved in feeding behavior 1029673 Co-Investigador Responsável (Co-IR) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Foundation for Prader-Willi Research Concluído
2023/06/01 - Atual	EURAS: EUropean network for neurodevelopmental RASopathies 101080580 Co-Investigador Responsável (Co-IR) Associação para o Desenvolvimento do Instituto Superior Técnico, Portugal	European Commission Em curso
2022/09/15 - Atual	Stem cell toolkit for modelling cerebellar dysfunction in Angelman Syndrome Research Grants on Angelman Syndrome Investigador responsável Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Angelman Syndrome Alliance Em curso
2026/02/23 - 2027/08/22	Decoding Epigenetic Disease Signatures in Twins Discordant for Systemic Lupus Erythematosus 2024.15228.PEX 10.54499/2024.15228.PEX Investigador Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2026/01/12 - 2027/07/11	Reversal of X-chromosome inactivation during naïve human iPSC reprogramming 2024.14670.PEX 10.54499/2024.14670.PEX Investigador responsável Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2023/03/06 - 2026/03/05	Estados pluripotentes transitórios como novos reservatórios de antigénios específicos contra o cancro 2022.01199.PTDC Investigador Universidade de Aveiro, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2023/01/01 - 2025/12/31	Dissecting the molecular mechanisms of X-chromosome inactivation using human embryonic stem cells 2022.01532.PTDC Investigador responsável Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2020/10/01 - 2024/03/31	RNA mis-splicing in hypertrophic cardiomyopathy: opportunities for diagnosis and therapy HR20-00322 Co-Investigador Responsável (Co-IR) Instituto de Medicina Molecular, Portugal	CaixaForum Barcelona Concluído
2021/01/01 - 2023/12/31	X-Chromosome Inactivation in Systemic Lupus Erythematosus EXPL/MED-OUT/1517/2021 Investigador Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018 - 2022/06/30	Deciphering the epigenetic aging barriers for iPSC reprogramming PTDC/BIA-MOL/29320/2017 Investigador responsável Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2020/03/01 - 2022/03/31	Exploring new therapeutic strategies for Angelman syndrome: A disease modelling approach based on 3D cerebellar organoids derived from patient iPSCs Pedro Maria José de Mello Costa Duarte Fellowship 2019 Investigador responsável Fundação Amélia de Mello, Portugal	Fundação Amélia de Mello Concluído
2018/04/20 - 2021/04/19	The role of long non-coding RNAs on the molecular circuitry and metabolic adaptation of breast cancer. PTDC/BTM-TEC/28534/2017 Investigador Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2019/01/02 - 2019/11/30	Monitoring the stability of X-chromosome inactivation during neuronal differentiation of human female iPSCs 20190026 Orientador Instituto de Medicina Molecular, Portugal	GABINETE DE APOIO À INVESTIGAÇÃO CIENTÍFICA, TECNOLÓGICA E INOVAÇÃO (GAPIC) Concluído
2016/06/01 - 2019/11/30	The non-coding transcriptome in stemness and aging PTDC/BIM-MED/0032/2014 Investigador Universidade de Aveiro, Portugal Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/06 - 2019/06	Comprehensive study of the dynamics of epigenetic processes involving lncRNAs during iPSC reprogramming PTDC/BEX-BCM/2612/2014 IC&DT Investigador responsável	Ministério da Ciência Tecnologia e Ensino Superior
2018/01/02 - 2018/11/30	How X-chromosome inactivation instability in human female iPSCs could affect disease modelling of X-linked disorders 20180038 Orientador Instituto de Medicina Molecular, Portugal	GABINETE DE APOIO À INVESTIGAÇÃO CIENTÍFICA, TECNOLÓGICA E INOVAÇÃO (GAPIC) Concluído
2018/01/02 - 2018/11/30	From mice to humans: a creation of a human model to assess the relation between UBE3A and mitochondrial activity in Angelman Syndrome patients 20180037 Orientador Instituto de Medicina Molecular, Portugal	GABINETE DE APOIO À INVESTIGAÇÃO CIENTÍFICA, TECNOLÓGICA E INOVAÇÃO (GAPIC) Concluído
2017/01/02 - 2017/11/30	Genetic dissection of conserved RNA modules of human XIST lncRNA implicated in X-inactivation using iPSCs 20170011 Orientador Instituto de Medicina Molecular, Portugal	GABINETE DE APOIO À INVESTIGAÇÃO CIENTÍFICA, TECNOLÓGICA E INOVAÇÃO (GAPIC) Concluído
2015/09/01 - 2017/08/31	Exploring new therapeutic strategies for Angelman syndrome: targeting the UBE3A antisense long non-coding RNA in neurons derived from Angelman syndrome patients PMJMCD 2015 Investigador responsável Instituto de Medicina Molecular, Portugal	Fundação Amélia de Mello Concluído

Projeto

	Designação	Financiadores
2025/03/01 - Atual	Institute for Health and Bioeconomy LA/P/0140/2020 10.54499/LA/P/0140/2020 Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal INESC Microsistemas e Nanotecnologias, Portugal Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade do Porto, Portugal Universidade Nova de Lisboa, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2022/11/15 - 2024/03/31	Rescuing defective X-chromosome inactivation in induced pluripotent stem cells for translational and clinical research 2021.00660.CEECIND Investigador Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2019/05/16 - 2022/11/14	Correcting imprinting defects in induced pluripotent stem cells (iPSCs) CEECUIND/01234/2017 Investigador Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2015/04/01 - 2019/05/14	Exploring the interplay between non-coding RNAs and chromatin modifying complexes in the establishment of defined chromatin states IF/00242/2014/CP1236/CT0009 Investigador Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009/07/01 - 2011/08/31	CHROMATIN DYNAMICS DURING X-INACTIVATION: ASSESSING THE ROLE OF DIFFERENT CHROMATIN CHANGES IN THE LOSS OF GENE ACTIVITY AND THE GAIN OF GENE SILENCING 237675 Bolseiro de Pós-Doutoramento Institut Curie, França	EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions Concluído
2008/05/19 - 2008/08/19	The role of H3K4 demethylases in X-chromosome inactivation ASTF 138-2008 Bolseiro de Pós-Doutoramento University of Copenhagen Biotech Research and Innovation Centre, Dinamarca	Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH Concluído
2008/05 - 2008/08	The role of H3K4 demethylases in X-chromosome inactivation ASTF 138-2008	Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH
2001/11/01 - 2005/10/31	The role of Delta-like 1 (Dlk1) in mouse development and metabolism SFRH/BD/5808/2001 Bolseiro de Doutoramento University of Cambridge Department of Physiology Development and Neuroscience, Reino Unido	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em boletim informativo	Maranga, Carina; Vieira, Adriana A.; Bekman, Evguenia; da Rocha, Simão T.. "Ensaios clínicos em Angelman... e em Portugal?", Newsletter trimestral da Angel, 2020, https://mcusercontent.com/c1201a436f7baec28794d7be1/files/85b64f55-3c95-4997-a30f-ceca8eeac0b0/Newsletter_14.pdf.
Artigo em revista	Soares, Mafalda; Wemans, Inês Saraiva; Caldas, Paulo; da Rocha, Simão Teixeira; Grosso, Ana Rita. "X-linked transcriptome dysregulation across immune cells in systemic lupus erythematosus". Biology of Sex Differences 16 1 (2025): https://doi.org/10.1186/s13293-025-00750-3. 10.1186/s13293-025-00750-3 Cazaux Mateus, Francisca; Camões dos Santos, João; Arez, Maria; Bekman, Evguenia P.; da Rocha, Simão T.. "A stem cell-based toolkit to model Angelman syndrome caused by paternal uniparental disomy of chromosome 15". Human Cell (2025): https://doi.org/10.1007/s13577-025-01287-8. Publicado Arez, Maria; da Rocha, Simão T.. "Why are imprints unstable in pluripotent stem cells?". Biochemical Society Transactions (2025): https://doi.org/10.1042/BST20243003. Publicado • 10.1042/BST20243003 Camões dos Santos, João; Cazaux Mateus, Francisca; Arez, Maria; Bekman, Evguenia P.; da Rocha, Simão T.. "Generation of two pairs of induced pluripotent stem cells from Angelman syndrome patients with class I 15q11.2-q13.1 deletions and their unaffected familial controls". Stem Cell Research (2025): https://doi.org/10.1016/j.scr.2025.103741. Publicado Raposo, Ana Cláudia; Caldas, Paulo; Jeremias, Joana; Arez, Maria; Cazaux Mateus, Francisca; Barbosa, Pedro; Sousa-Luís, Rui; et al. "Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation". Stem Cell Reports (2025): 102472. https://doi.org/10.1016/j.stemcr.2025.102472. 10.1016/j.stemcr.2025.102472 Jager, Joanna; Ribeiro, Marta; Furtado, Marta; Carvalho, Teresa; Syrris, Petros; Lopes, Luis R.; Elliott, Perry M.; et al. "Patient-derived induced pluripotent stem cells to study non-canonical splicing variants associated with Hypertrophic Cardiomyopathy". Stem Cell Research 81 (2024): 103582. https://doi.org/10.1016/j.scr.2024.103582. 10.1016/j.scr.2024.103582 Adriana A. Vieira; Inês Almada-Correia; Joana Inácio; Patrícia Costa-Reis; S. T. da Rocha. "Female-bias in systemic lupus erythematosus: How much is the X chromosome to blame?". Biology of Sex Differences (2024): https://doi.org/10.1186/s13293-024-00650-y. 10.1186/s13293-024-00650-y Eckersley-Maslin, Melanie A.; Teixeira da Rocha, Simão; Mancino, Samantha; Seneviratne, Janith; Mupo, Annalisa; Krueger, Felix; Oxley, David. Autor correspondente: Teixeira da Rocha, Simão. "Exploring the Stability of Genomic Imprinting and X-Chromosome Inactivation in the Aged Brain". Aging Biology 2 1 (2024): 20240030. https://doi.org/10.59368/agingbio.20240030. 10.59368/agingbio.20240030 Marta Ribeiro; Joanna Jager; Marta Furtado; Teresa Carvalho; Joaquim M. S. Cabral; Dulce Brito; Maria Carmo-Fonseca; Sandra Martins; Simão Teixeira da Rocha. "Generation of induced pluripotent stem cells from an individual with early onset and severe hypertrophic cardiomyopathy linked to MYBPC3: c.772G > A mutation". Human Cell (2024): https://doi.org/10.1007/s13577-024-01073-y. 10.1007/s13577-024-01073-y Ribeiro, Marta; Jager, Joanna; Furtado, Marta; Carvalho, Teresa; Cabral, Joaquim M.S.; Brito, Dulce; Carmo-Fonseca, Maria; Martins, Sandra; da Rocha, Simão Teixeira. "Generation of induced pluripotent stem cell lines from two unrelated individuals with familial hypertrophic cardiomyopathy carrying MYBPC3 nonsense mutations". Stem Cell Research 76 (2024): 103362. http://dx.doi.org/10.1016/j.scr.2024.103362. 10.1016/j.scr.2024.103362 Ribeiro, Marta; Martins, Sandra; Carvalho, Teresa; Furtado, Marta; Cabral, Joaquim Sampaio; Brito, Dulce; Carmo-Fonseca, Maria; da Rocha, Simao Teixeira. "Generation of induced pluripotent stem cell lines from two unrelated individuals with familial hypertrophic cardiomyopathy carrying the MYBPC3 missense c.1484G>A mutation". Stem Cell Research (2024): https://publons.com/wos-op/publon/65851693/. 10.1016/J.SCR.2023.103282 Camões dos Santos, João; Appleton, Carolina; Cazaux Mateus, Francisca; Covas, Rita; Bekman, Evguenia P.; da Rocha, Simão T.. Autor correspondente: da Rocha, Simão T.. "Stem cell models of Angelman syndrome". Frontiers in Cell and Developmental Biology 11 (2023): https://doi.org/10.3389/fcell.2023.1274040. Publicado da Rocha, Simao Teixeira; Lin, Shau-Ping; Youngson, Neil A.. "Editorial: Legacies of epigenetic perturbations". Frontiers in Cell and Developmental Biology (2023): https://publons.com/wos-op/publon/62686378/. 10.3389/FCELL.2023.1228115 Arez, Maria; Eckersley-Maslin, Melanie; Klobucar, Tajda; Lopes, Joao von Gilsa; Krueger, Felix; Mupo, Annalisa; Raposo, Ana Claudia; et al. "Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation". Nature Communications (2022): https://publons.com/wos-op/publon/54180959/. 10.1038/S41467-022-33013-5 Maranga, Carina; Pereira, Carolina; Roposa, Ana Claudia; Vieira, Adriana; Duarte, Sofia P.; Bekman, Evguenia; Milagre, Ines; da Rocha, Simao Teixeira. "Generation and characterization of induced pluripotent stem cell line (IBBISTi004-A) from an Angelman syndrome patient carrying a class II deletion of the maternal chromosome 15q11.2-q13". Stem Cell Research (2022): https://publons.com/wos-op/publon/54684002/. 10.1016/J.SCR.2022.102757 Raposo, Ana Cláudia; Casanova, Miguel; Gendrel, Anne-Valerie; da Rocha, Simão T.. "The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation". Biochemical Society Transactions 49 6 (2021): 2549-2560. http://dx.doi.org/10.1042/bst20210253. Publicado • 10.1042/bst20210253 Silva, Teresa P.; Pereira, Carolina A.; Raposo, Ana Cláudia; Oliveira, Ana Rita; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; Rocha, Simão Teixeira da. "Generation and characterization of induced pluripotent stem cells heterozygous for the Portuguese BRCA2 founder mutation". Stem Cell Research 53 (2021): 102364. http://dx.doi.org/10.1016/j.scr.2021.102364. 10.1016/j.scr.2021.102364 Silva, Teresa P.; Pereira, Carolina A.; Oliveira, Ana Rita; Raposo, Ana Cláudia; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; da Rocha, Simão T.. "Generation and characterization of induced pluripotent stem cells from a family carrying the BRCA1 mutation c.3612delA". Stem Cell Research 52 (2021): 102242. http://dx.doi.org/10.1016/j.scr.2021.102242. 10.1016/j.scr.2021.102242 Tjalsma, Sjoerd J D; Hori, Mayako; Sato, Yuko; Bousard, Aurelie; Ohi, Akito; Raposo, Ana Cláudia; Roensch, Julia; et al. "H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing". EMBO reports (2021): http://dx.doi.org/10.15252/embr.202051989. 10.15252/embr.202051989 Klobucar, Tajda; Kreibich, Elisa; Krueger, Felix; Arez, Maria; Pólvora-Brandão, Duarte; von Meyenn, Ferdinand; da Rocha, Simão Teixeira; Eckersley-Maslin, Melanie. "IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions (* co-last author)". Nucleic Acids Research 48 16 (2020): e92-e92. http://dx.doi.org/10.1093/nar/gkaa567. 10.1093/nar/gkaa567 Carina Maranga; Tiago G. Fernandes; Evguenia Bekman; da Rocha, Simão T.. "Angelman syndrome: a journey through the brain". The FEBS Journal (2020): https://doi.org/10.1111/febs.15258. 10.1111/febs.15258 Simão Teixeira da Rocha; Anne-Valerie Gendrel. "The influence of DNA methylation on monoallelic expression". Essays in Biochemistry 63 6 (2019): 663-676. https://doi.org/10.1042/EBC20190034. 10.1042/EBC20190034 Bousard, Aurélie; Raposo, Ana Cláudia; Zylicz, Jan Jakub; Pires, Vanessa Borges; Gil, Cláudia; Chang, Howard Y; Heard, Edith; da Rocha, Simão Teixeira. "The role of Xist -mediated Polycomb recruitment in the initiation of X-chromosome inactivation". EMBO reports 20 10 (2019): http://dx.doi.org/10.15252/embr.201948019. 10.15252/embr.201948019 Zylicz, Jan Jakub; Bousard, Aurélie; Žumer, Kristina; Dossin, Francois; Mohammad, Eusra; da Rocha, Simão Teixeira; Schwalb, Björn; et al. "The Implication of Early Chromatin Changes in X Chromosome Inactivation". Cell 176 1-2 (2019): 182-197.e23. http://dx.doi.org/10.1016/j.cell.2018.11.041. 10.1016/j.cell.2018.11.041 Sousa-Franco, António; Rebelo, Kenny; da Rocha, Simão Teixeira; Bernardes de Jesus, Bruno. "LncRNAs regulating stemness in aging". Aging Cell 18 1 (2018): e12870. http://dx.doi.org/10.1111/acel.12870. 10.1111/acel.12870 Pólvora-Brandão, Duarte; Joaquim, Mariana; Aprile, Domenico; Raposo, Ana Cláudia; Pereira de Almeida, Luís; Duarte, Sofia T; da Rocha, Simão T. "Loss of hierarchical imprinting regulation at the Prader–Willi/Angelman syndrome locus in human iPSCs". Human Molecular Genetics (2018): http://dx.doi.org/10.1093/hmg/ddy274. 10.1093/hmg/ddy274 Simão T da Rocha; Edith Heard. "Novel players in X inactivation: insights into Xist-mediated gene silencing and chromosome conformation". Nature Structural & Molecular Biology 24 3 (2017): 197-204. https://doi.org/10.1038%2Fnsmb.3370. 10.1038/nsmb.3370 Ci Chu; Qiangfeng Cliff Zhang; Simão Teixeira da Rocha; Ryan A. Flynn; Maheetha Bharadwaj; J. Mauro Calabrese; Terry Magnuson; Edith Heard; Howard Y. Chang. "Systematic Discovery of Xist RNA Binding Proteins". Cell 161 2 (2015): 404-416. https://doi.org/10.1016%2Fj.cell.2015.03.025. 10.1016/j.cell.2015.03.025 Serena Sanulli; Neil Justin; Simao T. da Rocha; Nicolas Servant; Steve J. Gamblin; Edith Heard; Raphaël Margueron. "Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation". Molecular Cell 57 5 (2015): 769-783. https://doi.org/10.1016%2Fj.molcel.2014.12.020. 10.1016/j.molcel.2014.12.020 Marika Charalambous; Simao Teixeira Da Rocha; Elizabeth Jane Radford; Gema Medina-Gomez; Scott Curran; Scarlett B. Pinnock; Sacri R. Ferrón; Antonio Vidal-Puig; Anne C. Ferguson-Smith. "DLK1/PREF1 regulates nutrient metabolism and protects from steatosis". Proceedings of the National Academy of Sciences 111 45 (2014): 16088-16093. https://doi.org/10.1073%2Fpnas.1406119111. 10.1073/pnas.1406119111 Simão Teixeira da Rocha; Valentina Boeva; Martin Escamilla-Del-Arenal; Katia Ancelin; Camille Granier; Neuza Reis Matias; Serena Sanulli; et al. "Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome". Molecular Cell 53 2 (2014): 301-316. https://doi.org/10.1016%2Fj.molcel.2014.01.002. 10.1016/j.molcel.2014.01.002 M. Escamilla-Del-Arenal; S. T. da Rocha; C. G. Spruijt; O. Masui; O. Renaud; A. H. Smits; R. Margueron; M. Vermeulen; E. Heard. "Cdyl, a New Partner of the Inactive X Chromosome and Potential Reader of H3K27me3 and H3K9me2". Molecular and Cellular Biology 33 24 (2013): 5005-5020. https://doi.org/10.1128%2Fmcb.00866-13. 10.1128/mcb.00866-13 M. Charalambous; S. T. da Rocha; A. Hernandez; A. C. Ferguson-Smith. "Perturbations to the IGF1 growth pathway and adult energy homeostasis following disruption of mouse chromosome 12 imprinting". Acta Physiologica 210 1 (2013): 174-187. https://doi.org/10.1111%2Fapha.12160. 10.1111/apha.12160 Marika Charalambous; Sacramento R. Ferron; Simao T. da Rocha; Andrew J. Murray; Timothy Rowland; Mitsuteru Ito; Karin Schuster-Gossler; Arturo Hernandez; Anne C. Ferguson-Smith. "Imprinted Gene Dosage Is Critical for the Transition to Independent Life". Cell Metabolism 15 2 (2012): 209-221. https://doi.org/10.1016%2Fj.cmet.2012.01.006. 10.1016/j.cmet.2012.01.006 Martin Escamilla-Del-Arenal; Simao Teixeira da Rocha; Edith Heard. "Evolutionary diversity and developmental regulation of X-chromosome inactivation". Human Genetics 130 2 (2011): 307-327. https://doi.org/10.1007%2Fs00439-011-1029-2. 10.1007/s00439-011-1029-2 Simao Teixeira da Rocha; Marika Charalambous; Shau-Ping Lin; Isabel Gutteridge; Yoko Ito; Dionne Gray; Wendy Dean; Anne C. Ferguson-Smith; Wolf Reik. "Gene Dosage Effects of the Imprinted Delta-Like Homologue 1 (Dlk1/Pref1) in Development: Implications for the Evolution of Imprinting". PLoS Genetics 5 2 (2009): e1000392-e1000392. https://doi.org/10.1371%2Fjournal.pgen.1000392. 10.1371/journal.pgen.1000392 Simao Teixeira da Rocha; Carol A. Edwards; Mitsuteru Ito; Tsutomu Ogata; Anne C. Ferguson-Smith. "Genomic imprinting at the mammalian Dlk1-Dio3 domain". Trends in Genetics 24 6 (2008): 306-316. https://doi.org/10.1016%2Fj.tig.2008.03.011. 10.1016/j.tig.2008.03.011 Simão T. da Rocha; Maxine Tevendale; Edward Knowles; Shuji Takada; Marie Watkins; Anne C. Ferguson-Smith. "Restricted co-expression of Dlk1 and the reciprocally imprinted non-coding RNA, Gtl2: Implications for cis-acting control". Developmental Biology 306 2 (2007): 810-823. https://doi.org/10.1016%2Fj.ydbio.2007.02.043. 10.1016/j.ydbio.2007.02.043 Marika Charalambous; Simão Teixeira da Rocha; Anne C Ferguson-Smith. "Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life". Current Opinion in Endocrinology, Diabetes and Obesity 14 1 (2007): 3-12. https://doi.org/10.1097%2Fmed.0b013e328013daa2. 10.1097/med.0b013e328013daa2 S.-P. Lin; P. Coan; S. T. da Rocha; H. Seitz; J. Cavaille; P.-W. Teng; S. Takada; A. C. Ferguson-Smith. "Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region". Development 134 2 (2007): 417-426. https://doi.org/10.1242%2Fdev.02726. 10.1242/dev.02726 Da Rocha, Simao Teixeira; Charalambous, M.; Medina-Gomez, G.; Angiolini, C.; Vidal-Puig, A. J.; Ferguson-Smith, A. C.. "Postnatal metabolic consequences of prenatal overexpression of Dlk1/Pref1 in mouse". Genetics Research (2007): https://publons.com/wos-op/publon/7601073/. Simao Teixeira da Rocha; Anne C. Ferguson-Smith. "Genomic imprinting". Current Biology 14 16 (2004): R646-R649. https://doi.org/10.1016%2Fj.cub.2004.08.007. 10.1016/j.cub.2004.08.007 Nara de Matos Granja; Raquel Soares; da Rocha, Simão T.; Joana Paredes; Adhemar Longatto Filho; Ven¿ncio Avancini Alves; Elizabeth Wiley; Fernando C. Schmitt; Carlos Bedrossian. "Evaluation of breast cancer metastases in pleural effusions by molecular biology techniques". Diagnostic Cytopathology 27 4 (2002): 210-213. https://doi.org/10.1002%2Fdc.10171. 10.1002/dc.10171
Capítulo de livro	Peres, Raquel; Camões dos Santos, João; da Rocha, Simão T.. "Stem Cell-Derived Cerebellar Organoids For Modelling Angelman Syndrome". 2025. Submetido Maranga, Carina; Vieira, Adriana; Bekman, Evguenia P.; da Rocha, Simão T.. "Chapter 9: Induced pluripotent stem cells for modeling Angelman syndrome". In iPSCs for Modeling Central Nervous System Disorders. Elsevier, 2021. Publicado
Entrada de enciclopédia	Pólvora Brandão, Duarte; da Rocha, Simão T. "Genomic Imprinting at the Transcriptional Level". In eLS. John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9780470015902.a0005686.pub3. 10.1002/9780470015902.a0005686.pub3 Simão Teixeira da Rocha; Edith Heard. "Genomic Imprinting at the Transcriptional Level". In eLS, 2011. 10.1002/9780470015902.a0005686.pub2
Poster em conferência	da Rocha, Simão T.; Arez, Maria; Cazaux Mateus, Francisca; Caldas, Paulo. Autor correspondente: da Rocha, Simão T.. "Imprinting and X-Chromosome Inactivation Are Vulnerable to Epigenetic Rewiring During Human iPSC Reprogramming". Trabalho apresentado em 14th International Meeting of the Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC), 2025. Cazaux Mateus, Francisca; Camões dos Santos, João; Arez, Maria; Bekman, Evguenia; da Rocha, Simão T.. "Establishing an Induced Pluripotent Stem Cell Model of Angelman Syndrome Caused by Paternal Uniparental Disomy of Chromosome 15". Trabalho apresentado em BioManufacturing Without Borders 2024, 2024. Camões dos Santos, João; Cazaux Mateus, Francisca; Arez, Maria; Bekman, Evguenia P.; da Rocha, Simão T.. Autor correspondente: da Rocha, Simão T.. "A Novel Stem Cell Toolkit to Advance Therapeutics in Angelman Syndrome". Trabalho apresentado em 8th ASA Scientific Meeting, 2024. Arez, Maria; Caldas, Paulo; Sansone, Melissa; Oxley, David; da Rocha, Simão T.. "How do imprints cope during reprogramming of female and male human iPSCs?". Trabalho apresentado em ISSCR 2024 Annual Meeting, 2024. Camões dos Santos, João; Cazaux Mateus, Francisca; Arez, Maria; Bekman, Evguenia P.; da Rocha, Simão T.. Autor correspondente: da Rocha, Simão T.. "Stem Cell Toolkit to Advance Therapeutics in Angelman Syndrome". Trabalho apresentado em 2024 ISSCR Annual Meeting, 2024. Cazaux Mateus, Francisca; Camões dos Santos, João; Arez, Maria; Bekman, Evguenia; da Rocha, Simão T.. "A novel Stem Cell Model for Angelman Syndrome caused by Paternal Uniparental Disomy of Chromosome 15". Trabalho apresentado em IBB Meeting 2023, 2023. Cazaux Mateus, Francisca; Camões dos Santos, João; Arez, Maria; Bekman, Evguenia; da Rocha, Simão T.. "Stem Cell-Based Disease Modeling Of Angelman Syndrome Caused by Paternal Uniparental Disomy for Chromosome 15". Trabalho apresentado em SPCE-ETRS Joint Annual Meeting 2023, 2023. Nunes, Ana Catarina; Laura Dias; Miguel Casanova; da Rocha, Simão T.. "Regulation of X-Chromosome inactivation in human female embryonic stem cells". Trabalho apresentado em ETRS & SPCE-TC Joint Meeting, 2023. da Rocha, Simão T.. "Between active and inactive: a tale of the eroded X (Xe) in female human pluripotent stem cells". Trabalho apresentado em EMBO Workshop on X-chromosome inactivation: new insights on its 60th anniversary, 2023. Arez, Maria; Gouveia, Maria; Raposo, Ana Cláudia; Krueger, Felix; Mupo, Annalisa; Eckersley-Maslin, Melanie; da Rocha, Simão T.. "Why is genomic imprinting dysregulated during reprogramming of iPSCs?". Trabalho apresentado em Genomic Imprinting 2023, 2023. Arez, Maria; Eckersley-Maslin, Melanie; Klobucar, Tajda; von Gilsa Lopes, João; Krueger, Felix; Mupo, Annalisa; Raposo, Ana Cláudia; et al. "Sex of donor cell and medium formulation as predictors of imprinting disruption in mouse iPSCs". Trabalho apresentado em 6th Max Planck Epigenetics Meeting 2022, 2022. da Rocha, Simão T.; Arez, Maria; Eckersey-Maslin, Melanie ; Klobucar, Tajda; Lopes, João Von Gilsa; Krueger, Felix; Raposo, Ana Cláudia; et al. "Strategies to avoid imprinting defects in induced pluripotent stem cells.". Trabalho apresentado em ISSCR 2022 Annual Meeting - International Society for Stem Cell Research,, 2022. da Rocha, Simão T.; Maranga, Carina (7811-C66B-F64C); Ana Cláudia Raposo; Vieira, Adriana; Arez, Maria; Gomes, Alípio; Dias, Laura; Casanova. Miguel; Bekman, Evguenia P.. "A personalized stem cell toolkit for modeling human disorders". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim M.S; da Rocha, Simão T.; Fernandes, Tiago G.; Bekman, Evguenia. "Modeling Angelman Syndrome with human induced pluripotent stem cell-derived cerebellar organoids". Trabalho apresentado em Vienna Biocenter PhD Symposium 2021 'Building Bridges', 2021. da Rocha, Simão T.; Arez, Maria; Eskersley-Maslin, Melanie; Klobucar, Tajda; João von Gilsa Lopes; Krueger, Felix; Ana Cláudia Raposo; Gendrel, Anne-Valerie; Bernades de Jesus, Bruno. "IMPLICON reveals the predictors of imprinting defects in mouse iPSCs". Trabalho apresentado em Virtual EMBL Conference on Epigenetics and Chromatin, 2021. Maranga, Carina; Vieira, Adriana A; Fernandes, Tiago G.; Cabral, Joaquim M. S.; da Rocha, Simão T.; Bekman, Evguenia P.. "Brain-in-a-dish approach for studying Angelman Syndrome". Trabalho apresentado em Neuroepigenetics: From Cells to Behaviour and Disease Virtual EMBO Workshop, 2020. Pereira da Silva, Teresa; da Rocha, Simão T.; Milagre, INÊS; Pereira, Carolina; Cabral, Joaquim S; Carmo-Fonseca, Maria. "iPSC-derived mammary organoids as a model to study the onset of malignant transformation triggered by BRCA mutations". Trabalho apresentado em EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, 2020. Maranga, Carina; Silva, Teresa P.; Fernandes, Tiago G.; da Rocha, Simão T.; Bekman, Evguenia P.; Cabral, Joaquim M. S.. "hiPSC-derived cerebellar organoids to model Angelman Syndrome". Trabalho apresentado em Organoids: Modelling Organ Development and Disease in 3D culture, Virtual EMBO Conference, 2020. Vieira, Adriana A.; Maranga, Carina; Gomes, Ana; Bekman, Evguenia; da Rocha, Simão T.. "Modeling of Angelman Syndrome using the Neural Commitment of Patient-Specific iPSCs". Trabalho apresentado em Innovate Competition ¿ AstraZeneca Foundation, 2020. da Rocha, Simão T.; Pereira, Carolina; Ferreira, Catarina; Bak-Gordon P; Milagre, INÊS; Carmo-Fonseca M. "Generation of patient-derived iPSCs for disease modelling". Trabalho apresentado em EATRIS Annual Meeting, 2020. Arez, Maria; Eckersley-Maslin, Melanie; Von Gilsa, João; GENDREL, ANNE-VALERIE; Raposo, Ana; Bernardes de Jesus, Bruno; da Rocha, Simão T.. "Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs". Trabalho apresentado em 11th Edition of the International Meeting of the Portuguese Society for Stem Cells & Cell Therapies, 2019. da Rocha, Simão T.; Bousard Aurelie; Raposo, Ana C; Zylicz, Jan Jakub; Picard, Christel; Pires, Vanessa Borges; Qi, Yanyan; et al. "Exploring the Role of Xist-mediated Polycomb Recruitment in the Initiation of Transcriptional Silencing of the X Chromosome.". Trabalho apresentado em 3rd International Symposium on Frontiers in Molecular Science on RNA Regulatory Networks, 2019. da Rocha, Simão T.; Bousard, Aurélie; Zylicz, Jan Jakub; Raposo, Ana Cláudia; Picard, Christel; Pires, Vanessa Borges; Qi, Yanyan; et al. "Genetic dissection of Xist lncRNA reveals independent modules involved in transcriptional silencing and heterochromatin formation". Trabalho apresentado em EMBO/EMBL symposium: "The Complex Life of RNA”, 2018. da Rocha, Simão T.; Bousard, Aurélie; Zylicz, Jan Jakub; Raposo, AC; Picard, Christel; Pires, Vanessa Borges; Qi, Yanyan; et al. "Genetic dissection of Xist lncRNA reveals independent modules involved in transcriptional silencing and heterochromatin formation". Trabalho apresentado em EMBO meeting on “Transcription and Chromatin”, 2018. da Rocha, Simão T.; Pólvora-Brandão, Duarte; Joaquim, Mariana; Aprile, Domenico; Pereira de Almeida, Luís; Duarte, Sofia. "Loss of imprinting at the 15q11-q13 region during reprogramming results in a novel iPSC model for Angelman syndrome.". Trabalho apresentado em Cold Spring Harbor meeting on “Stem Cell Biology”, 2017. da Rocha, Simão T.; Pires, Vanessa Borges; Raposo, Ana Cláudia; Picard, Christel; Heard, Edith. "Genetic dissection of Xist lncRNA reveals conserved functional RNA domains involved in facultative heterochromatin formation during X-inactivation". Trabalho apresentado em EMBO meeting on “Chromatin and Epigenetics”, 2017. da Rocha, Simão T.; Pires, Vanessa Borges; Raposo, Ana Cláudia; Heard, Edith. "Genetic dissection of Xist reveals mechanistic insights of conserved functional RNA domains". Trabalho apresentado em Royal Society Meeting on “X-chromosome inactivation: a tribute to Mary Lyon”, 2016. da Rocha, Simão T.; Boeva, Valentina; Martin Escamilla-Del-Arenal; Katia Ancelin; Granier, Camille; Matias, Neuza; Sanulli, Serena; et al. "JARID2 participates in the initial targeting of PRC2 to the inactive X chromosome.". Trabalho apresentado em Epigenesys Meeting, 2013. da Rocha, Simão T.; Martin Escamilla-Del-Arenal; Matias, Neuza; Granier, Camille; Sanulli, Serena; Wutz, A; Reinberg, Danny; Margueron, Raphael; Heard, Edith. "Exploring the role of JARID2 in the chromatin events associated with the initiation of X-chromosome inactivation.". Trabalho apresentado em Abcam Meeting on “Chromatin: From Structure to Epigenetics”, 2012. da Rocha, Simão T.; Lin, Shau-Ping; Ito, Mitsuteru; Angiolini, Chris; Watkins, Marie; Dean, Wendy; Anne C. Ferguson-Smith. "The Function and Regulation of the Imprinted Gene Delta-like 1 (Dlk1) in Mouse Development". Trabalho apresentado em Gordon Conference on “Epigenetics”, 2005. da Rocha, Simão T.; Lin, Shau-Ping; Angiolini, Chris; Watkins, Marie; Dean, Wendy; Anne C. Ferguson-Smith. "The role of Delta-like 1 (Dlk1) in mouse development: a transgenic approach.". Trabalho apresentado em Cold Spring Harbor Laboratory Meeting on “Mouse Molecular Genetics”, 2004.
Pré-impressão	Maranga, Carina; Vieira, Adriana A.; Camões dos Santos, João; Silva, Teresa P.; Gonçalves-Ribeiro, Joana; Chebli, Karim; Casanova, Miguel; et al. Autor correspondente: da Rocha, Simão T.. "Stem-cell modeling of cerebellar dysfunction of Angelman syndrome". 2025. https://doi.org/10.1101/2025.08.07.669046. 10.1101/2025.08.07.669046
Resumo em conferência	Maranga, Carina; Pereira da Silva, Teresa; Vaz Sandra; da Rocha, Simão T.; Fernandes, Tiago G.; Bekman, Evguenia P.; Cabral, Joaquim S. "Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids". 2019. Publicado Marika Charalambous; da Rocha, Simão T.; Anne Ferguson-Smith. "DLK1/PREF1 prevents hepatosteatosis by elevating pituitary GH secretion". 2014. 10.1530/endoabs.34.p224
Tese / Dissertação	da Rocha, Simão T.. "The role of Delta-like 1 (Dlk1) in mouse development and metabolism". Doutoramento, University of Cambridge Department of Physiology Development and Neuroscience, 2007.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2025/10/10	Stem-cell modeling of cerebellar dysfunction in Angelman syndrome	32nd Annual Congress of the ESGCT - European Society of Gene and Cell Therapy European Society of Gene and Cell Therapy (ESGCT) (Seville, Espanha)
2025/07/15	WP3: Generation and validation of disease models	4th Progress Meeting of the EURAS Consortium EURAS Consortium (Turku, Finlândia)
2025/06/11	XIST and the maintenance of XCI: lessons from XCI erosion in human pluripotent stem cells.	X-chromosome inactivation Symposium Collège de France (Paris, França)
2025/03/12	da Rocha ST, Caldas P, Raposo AC, Jeremias J, Arez M, Cazaux Mateus F, Grosso AR. Erosion of X-Chromosome Inactivation in Human Pluripotent Stem Cells Reveals Insights into XIST-Mediated Regulation of Escape Genes	Wellcome Connecting Science Conference on Genomic Imprinting – from Biology to Disease Wellcome Connecting Science (Hinxton, Reino Unido)
2024/08/01	Stem cell toolkit for modelling cerebellar dysfunction in Angelman Syndrome	ASA Scientific Conference & AngelmanUK Family Conference Angelman Syndrome Alliance (Coventry, Reino Unido)
2023/03/23	A stem cell-based model of Angelman syndrome	Genomic Imprinting - from Biology to Disease Wellcome Connecting Science (Cambridge, Reino Unido)
2023/01/26	Consequences of XIST lncRNA loss of expression in female human stem cells,	RNA in Disease IX ptRNA meeting RNA in Disease IX ptRNA meeting (Lisbon, Portugal)
2022/09/15	Stem cell toolkit for modelling cerebellar dysfunction in Angelman Syndrome	7th International Scientific Conference on Angelman Syndrome Angelman Syndrome Alliance (Vienna, Áustria)
2022/07	A brain-in-a-dish approach to model Angelman syndrome.	RIBOMED Satellite Conference on RNA in Disease at the Biochemistry Global Summit IUBMB-FEBS-PABMB (Lisbon, Portugal)
2022/05/04	Epigenetic fidelity of induced pluripotent stem cells	Invited Lecture NOVA Medical School (Lisbon, Portugal)
2020/12/14	From reprogramming to disease modeling: the assets and drawbacks of induced pluripotent stem cells.	Invited talk at DBE Seminars Department of Bioengineering, Instituto Superior Técnico (Lisbon, Portugal)
2020/09/30	IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions.	"Genomic Imprinting – From Biology to Disease” Virtual Meeting International Genomic Imprinting Society (Cambridge (virtual), Reino Unido)
2020/05/27	Síndrome de Angelman: Ensaios clínicos e Mini cérebros"	Virtual meeting with Associação Síndrome de Angelman Portugal Associação Síndrome de Angelman Portugal (-, Portugal)
2019/11/28	Epigenetic variability of iPSCs: consequences for disease modelling.	Invited talk at nstitut de Génétique Moléculaire de Montpellier (IGMM), CNRS & University of Montpellier, Montpellier, FRANCE Institut de Génétique Moléculaire de Montpellier (Montpellier, França)
2019/10/10	Epigenetic variability in iPSCs: causes and consequences.	11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies. Portuguese Society for Stem Cells and Cell Therapies (Lisboa, Portugal)
2019/06/28	Epigenetic variability of iPSCs.	Edith HEARD 17 years of e(Xist)ing at Curie Institut Curie (Paris, França)
2019/03/12	Exploring the role of Polycomb recruitment in Xist-mediated silencing of the X chromosome in ES cells	Keystone Symposium Conference on Epigenetics and Human Diseases (X5). Keystone Symposia (Banff, Canadá)
2019/02/13	The impact of epigenetic variability in pluripotent stem cells: mechanistic insights in lncRNA-mediated epigenetic changes	Invited talk at IBIMED, University of Aveiro, PORTUGAL. IBIMED, University of Aveiro (Aveiro, Portugal)
2017/10/10	Systematic DNA methylation analysis reveals prevalence of imprinting defects in mouse iPSCs	10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies Portuguese Society for Stem Cells and Cell Therapies (Covilhã, Portugal)
2016/09/28	Angelman syndrome, human genetics, RNA and beyond	5th Angelman International Scientific Conference Angelman Syndrome Alliance (Lisboa, Portugal)
2016/05/03	Xist RNA dependent JARID2 recruitment is crucial for efficient PRC2 targeting to the inactive X-chromosome	EMBO/EMBL meeting on “Epigenetics and Chromatin” May 2013, EMBO, Heidelberg, Germany. EMBO/EMBL (Heidelberg, Alemanha)
2016/03/05	Mechanistic insights into Xist lncRNA-mediated recruitment of chromatin modifiers during X-chromosome inactivation.	Invited talk at CNC/UC-Biotech, Coimbra, PORTUGAL CNC/UC-Biotech, Universidade de Coimbra (Coimbra, Portugal)
2016/02/10	Mechanistic insights into Xist lncRNA-mediated recruitment of chromatin modifiers	EMBO Workshop on “Systems Biology of non-coding RNAs” EMBO (Rohovot)
2013/05/12	Xist RNA dependent JARID2 recruitment is crucial for efficient PRC2 targeting to the inactive X-chromosome	EMBO meeting on “Epigenetics and Chromatin” European Molecular Biology Organization (Heidelberg, Alemanha)
2007/09/08	Dosage effects of Dlk1/Pref1 in pre-natal mouse development: implications for control by genomic imprinting	Wellcome Trust Conference on ¿Mouse Molecular Genetics Wellcome Trust (Hinxton, Reino Unido)
2006/11/24	Postnatal metabolic consequences of prenatal over-expression of Dlk1/Pref1 in mouse.	Rank Prize Mini-Symposium in Nutrigenomics Rank Prize (Windemere, Reino Unido)
2006/11/17	Postnatal metabolic consequences of prenatal over-expression of Dlk1/Pref1 in mouse	The Genetics Society’s 17th Mammalian Genetics and Development Workshop The UK Genetics Society (London, Reino Unido)
2006/09/15	The role of the imprinted gene Delta-like 1 (Dlk1) in mouse metabolism.	Cold Spring Harbour Symposium in “Mouse Molecular Genetics” Cold Spring Harbour Symposia (Cold Spring Harbour, Estados Unidos)
2005/04/15	The role of the imprinted gene Delta-like 1(Dlk1) in mouse development: a transgenic approach.	Harwell Imprinting Conference 2005 on “Genomic Imprinting, Development and Disease” Harwell Imprinting Conference (Oxford, Reino Unido)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2026/02/15 - Atual	Gene Editing to Create a Stem Cell Model of Cardio-Facio-Cutaneous Syndrome Orientador de Carolina Inácio	Biotecnologia (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2025/09/15 - Atual	Decoding the impact of patient-specific SYNGAP1 mutations using Forebrain Organoids derived from Gene-Edited Stem Cells Orientador de Joana Jeremias	Bioengenharia (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2025/06/01 - Atual	Addressing Imprinting Defects in Induced Pluripotent Stem Cells (iPSCs) to Enhance their Biomedical Potential Coorientador de Mariana de Almeida Caetano Perdigão Luz	Biology (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2025/02/01 - Atual	Ensuring reversal of X-chromosome inactivation during naïve iPSC reprogramming Orientador de Francisca Mateus	Bioengenharia (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2024/02/01 - Atual	An Isogenic Stem Cell Tool Kit to Advance Therapeutics in Angelman Syndrome Orientador de João Camões dos Santos	PhD Program in Bioengineering – Cell Therapies and Regenerative Medicine (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2024/09/15 - 2026/01/10	Advancing therapeutics in Angelman Syndrome: A fluorescence-based approach to drug screenings using engineered human embryonic stem cells Coorientador de Diana Carrasqueira	Biologia do Organismo e Evoluc¸a~o (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2025/02/15 - 2025/10/31	Exploring the role of RNF20 and RNF40 in X-chromosome inactivation regulation using human female embryonic stem cells. Orientador de Joana Vieira Santos	Biotecnologia (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/04/05 - 2025/05/13	Assessing the impact of imprinting defects in human iPSCs: Is cell therapy safe? Orientador de Maria Arez	PhD Program in Bioengineering – Cell Therapies and Regenerative Medicine (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/09/01 - 2024/11/30	X-chromosome inactivation in systemic lupus erythematosus Coorientador de Joana Inácio	Molecular Genetics and Biomedicine (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/12/01 - 2024/10/23	Functional dissection of the XIST non-coding RNA in X-chromosome inactivation in human ESCs Orientador de Ana Cláudia Raposo	PhD in Biomedicine (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2019/12/01 - 2024/09/05	Exploiting the role of long non-coding RNAs in the direct conversion of fibroblasts into functional cardiomyocytes and neurons Coorientador de Francisco José Furtado Santos	PhD in Biomedical Sciences (Doutoramento) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2023/03 - 2024/02/28	The role of RNF20/RNF40 in X-chromosome inactivation Orientador de Mahdi Moradi	Medical Biotechnology (Mestrado) Università degli Studi di Bologna, Itália
2022/09/05 - 2024/02/20	hiPSC-based brain organoid models to study Angelman syndrome Coorientador de Carolina Appletion	MSc in Evolutionary and Developmental Biology (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2022/09 - 2023/12/07	Erosion of X-chromosome inactivation in human female embryonic stem cells Orientador de Joana Jeremias	MSc in Biological Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02 - 2023/11/29	Dissecting the molecular mechanisms of X-chromosome inactivation using human pluripotent stem cells Orientador	MSc in Biotechnology Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/03/01 - 2023/11/18	Modelling Angelman syndrome in CRISPR-edited isogenic iPSCs. Coorientador de Alípio Gomes	Biological Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02 - 2023/07	Epigenetic fidelity of human pluripotent stem cells (iPSCs) Orientador	Biology: From fundamental molecular biosciences to biotherapies option (Iniciação científica) Sorbonne Université, França
2022/09 - 2023/01	Hypertrophic Cardiomyopathy: generation of patient specific induced pluripotent stem cell derived cardiomyocytes for improved diagnostics and novel therapies Orientador	Biotechnology (Iniciação científica) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/03/01 - 2022/07/03	Generation of genetically engineered human embryonic stem cells using CRISPR-Cas9 A toolbox for human disease modelling Coorientador de Laura Dias	Biological Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/03 - 2022/07	Epigenetic regulation of X-chromosome inactivation in female human iPSCs Orientador	BSc in Biological Engineering (Iniciação científica) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/02/01 - 2022/06/30	Analysis of epigenetic defects in human induced pluripotent stem cells Orientador	Biochesmitry (Iniciação científica) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/03/01 - 2022/06/30	Cerebellar organoids derived from hiPSCs to model Angelman syndrome Coorientador de Carina Maranga	PhD Program in Bioengineering – Cell Therapies and Regenerative Medicine (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/09/01 - 2021/02/24	In Vitro Modeling of Angelman Syndrome using the Neural Commitment of Patient-Specific iPSCs Coorientador de Adriana Vieira	MSc in Molecular Biology and Genetics (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/01 - 2021/02/06	Editing of the ADORA2A gene by CRISPR/Cas9 Orientador	Neurosciences (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2017/01/02 - 2020/12/18	Instability of X-chromosome inactivation in female human iPSCs Orientador	MSc in Medicine (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2019/05/01 - 2020/06/24	Characterization of genomic imprinting defects during mouse iPSC generation Orientador de Tadja Klobucar	MSc in Biotechnology (Mestrado) Univerza v Ljubljani Biotehniska fakulteta, Eslovénia
2018/09/01 - 2019/11/06	Functional dissection of the Xist lncRNA conserved sequences in X-chromosome inactivation Orientador de Cláudia Gil	MSc in Molecular Biology and Genetics (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2018/02/01 - 2018/10/30	A disease modelling approach for Angelman syndrome based on neuronal differentiation of human patient-derived iPSCs Orientador de Ana Guerreiro	Biological Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/09/01 - 2018/10/15	Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs Orientador de Maria Arez	MSc in Molecular Genetics and Biomedicine (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/09/01 - 2018/10/10	The role of Meg3 lncRNA in imprinting and pluripotency Orientador	MSc in Molecular Biology and Genetics (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2018/01/02 - 2018/09/30	From mice to humans: a creation of a human model to assess the relation between UBE3A and mitochondrial activity in Angelman Syndrome patients.” Orientador	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2018/01 - 2018/09	3. Jan-Sept 2018: Inês Pinto, GAPIC (Gabinete de apoio à investigação científica, tecnológica e inovação) project: From mice to humans: a creation of a human model to assess the relation between UBE3A and mitochondrial activity in Angelman Syndrome patients, MSc in Medicine, Faculty of Medicine, University of Lisbon (as a main supervisor). Orientador	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2016/09/01 - 2017/10/30	Exploring cell reprogramming techniques for Angelman syndrome disease modelling Orientador de Mariana Joaquim	MSc in Molecular Genetics and Biomedicine (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/02/01 - 2017/02/28	Monitoring epigenetic stability in induced Pluripotent Stem Cells Orientador	MSc in Biological Sciences: Molecular diagnostics (Mestrado) Università degli Studi di Napoli Federico II, Itália
2016/02/01 - 2016/11/15	Comprehensive study of the stability of genomic imprinting during iPSC reprogramming Orientador	MSc in Biomedical Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - 2016/10/15	Generation and characterization of Angelman Syndrome iPSCs for disease modelling and drug screening. Orientador	MSc in Molecular and Cellular Biology (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2009/09/01 - 2010/10/25	Exploring the role of the Jumonji/ARID1 family of proteins during embryonic stem cell differentiation and X-chromosome inactivation Orientador	MSc in Molecular Biology and Genetics (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2024/04/15 - Atual	Coordinator of SPCE-TC Webcasts: annual webinars with two international speakers and two young researchers (postdocs or PhD students) on stem cells and cell therapies (co-organized with Dr. Liliana Bernardino and Dr. Susana Solá in the context of the Portuguese Society of Stem Cells and Cell Therapies - SPCE-TC) from 2024-ongoing. (2024/04/15) Seminário (Coorganizador)	Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2021/02 - 2023/12/31	SCERG seminars - Weekly seminars of the Stem Cell Engineering Research Group (SCERG) featuring internal seminars and invited external speakers. (2021/02 - 2023/12/31) Seminário (Presidente da Comissão Organizadora)	Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2019/03/10 - 2020/02/20	Lisbon Area - Stem Cell Club The aim of these meetings is to share knowledge in stem cells and foster collaborative work within the stem cell community in the greater Lisbon area. Each event comprises of two talks by invited speakers, followed by discussions in an informal setting every two months. (2019/03/10 - 2020/02/20) Seminário (Coorganizador)	Instituto de Medicina Molecular, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2021/11/06 - Atual	1st Open Day IST Taguspark 2021 Outro	Open Day IST Taguspark Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/02/27 - 2020/02/27	Participation in the webinar Doenças Raras: Perspectivas Actuais e o Futuro Mesa-redonda	E_CONVERSAS NA FMUL Universidade de Lisboa Faculdade de Medicina, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2026/03/17	Dand5 as a regulator of differentiation and mature readiness of PSC-CMS Arguente	Micael de Jesus Almeida (Doutoramento) Universidade Nova de Lisboa Medical School, Portugal
2026/02	Deciphering the role of TET2 as an epigenetic regulator of adult neural stem cell function Vogal	Laura Lázaro Carot (Doutoramento) Universitat de València, Espanha
2025/04/23	SRRM2 splicing factor modulates cell fate in early development Arguente principal	Sílvia Camoeira Carvalho (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2025/04	Investigating the epigenetic regulator SMCHD1 as a potential therapeutic target for the treatment of Prader-Willi Syndrome and Schaaf-Yang Syndrome Vogal	Megan Iminitoff (Doutoramento) The University of Melbourne, Austrália
2024/09/17	Regulatory mechanisms of gene expression during development Arguente	Dr. Rafael Martins Galupa (Agregação) Université de Toulouse, França
2024/04/10	Cell-based therapies for regenerative medicine and cancer Arguente principal	Paula Magda Teixeira Correia (Doutoramento) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2023/12/20	Nutritional and aging-associated barriers to cell reprogramming Arguente principal	Rafaela Monteiro Dias (Mestrado) Universidade de Aveiro, Portugal
2023/12/05	TERRA-mediated recruitment of SMARCAL1 in response to telomeric replication stress Arguente principal	João Pedro Pina Rebelo (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/03/29	Epigenetics and Genetics of hematopoietic stem cells heterogeneity Vogal	Nadiya Kubasova (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/02	Exploring the contribution of transposable elements for the pathogenesis of Rett syndrome Arguente principal	Margarida Bettencourt (Outro) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/11	Interplay of TET1 in Wnt signalling in neural induction mediated by TCF7L1 Arguente principal	Mariana Schroiff Nogueira Antunes (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/06/23	Toward Chromosome 6 Replacement in hPSCs by Editing Nucleases and Microcell Mediated Chromosome Transfer (MMCT) Arguente principal	João Manuel Coelho Carreira (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/12/14	Transcriptional Program Biosensors for Human Cell Type and State Diagnosis Arguente principal	Benilde Francisco Pondeca (Doutoramento) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021/11/30	Establishing cellular models to investigate the role of LINE-1 elements in X-chromosome inactivation and genome stability Arguente principal	Inês Cardial Mendes Dias (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/01/18	TERRA Transcription Profiles in Human Cancer Cells Arguente principal	Miguel Filipe Martins Louro Alves (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/07/24	Exploiting the role of long non-coding RNAs in the direct conversion of fibroblasts into functional cardiomyocytes Departamento do Biologia, Universidade de Aveiro 24/07/2020 Masters in Score: 18/20 Arguente principal	Paula Magda Teixeira Correia (Mestrado) Universidade de Aveiro Departamento de Biologia, Portugal
2019/12/18	How the lncRNA Zeb2-NAT regulates the expression of Zeb2 Arguente principal	Miguel Francisco Cruz Romano Guedes (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11/26	Role of Cerl2 in the Modulation of Nodal and Wnt/B-catenin Pathways in Mouse Embrionic Stem Cells to Study Cardiomyocyte Differentiation Arguente principal	Mariana Simas Faria (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/11/18	Chronic neuropathic pain: the role for imprinted genes in pain modulation Arguente principal	Carlos Daniel Pinheiro da Silva Vasconcelos (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2018/10/13	Programmed DNA damage as a new tool to regulate gene activation Arguente principal	Cristiana Morgado (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2016/11/09	Understanding the role of parasites epitranscriptome Arguente principal	João Miguel Barbosa Nina (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2016/06/22	A long non-coding RNA regulating cellular reprogramming Arguente principal	Sara Azevedo Barros (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2016/03/12	Analysis of the gene regulatory network underlying pluripotenciality in mouse embryonic stem cells Arguente principal	Ana Marisa Mendes Gonçalves Vinhais Guedes (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2025/10/07 - 2025/10/10	32th European Society of Gene and Cell Therapy (ESGCT) Annual Congress, Seville, Spain	European Society of Gene and Cell Therapy (ESGCT)
2024/10/22 - 2024/10/25	31th European Society of Gene and Cell Therapy (ESGCT) Annual Congress, Rome, Italy, 22-25th Oct 2024.	European Society of Gene and Cell Therapy (ESGCT)
2023/10/24 - 2023/10/27	30th European Society of Gene and Cell Therapy (ESGCT) Annual Congress	European Society of Gene and Cell Therapy (ESGCT)
2023/10/11 - 2023/10/13	European Tissue Repair Society (ETRS) & Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC) Annual Joint meeting	European Tissue Repair Society (ETRS) & Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC)

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2025 - Atual	Epigenetics (1559-2308)	Taylor & Francis
2020/11/05 - Atual	Review Editor in Developmental Epigenetics for the Journal Frontiers in Cell and Developmental Biology. (2296634X)

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2025 - Atual	Scientific Evaluator of a project grant from the France “Sclérose en Plaques” Foundation in 2025. Avaliador	Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques, França	Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
2026/02 - 2026/02	Scientific Evaluator of a project grant from the "Fondation pour la Recherche Médicale" (FRM), France in 2026 Avaliador	Fondation pour la Recherche Médicale, França	Fondation pour la Recherche Médicale
2023 - 2023	Scientific Evaluator of the EJP RD – European Joint Programme on Rare Disease – Networking Support Scheme (NSS) Call (https://www.ejprarediseases.org/our-actions-and-services/funding-opportunities/calls/networking-support/) in 2023. Avaliador	European Joint Programme on Rare Disease – Networking Support Scheme (NSS) , Bélgica	European Joint Programme on Rare Disease – Networking Support Scheme (NSS)
2021 - 2021	Scientific Evaluator of a project grants from the French National Research Agency (ANR) in 2021. Avaliador	Agence nationale de la recherche, França	Agence nationale de la recherche

Consultoria / Parecer

	Descrição da atividade	Instituição / Organização
2026/01 - Atual	Consultant for the cell agriculture company Cell4Food, advising on omics, cell culture, and gene editing.	Cell4Food, Portugal

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2024/09/07 - Atual	Molecular Biology and Genetics	Molecular Biology and Genetics (Bacharelato)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2024/04/20 - Atual	Biochemistry and Molecular Biology of the Cell	Biochemistry and Molecular Biology of the Cell (Bacharelato)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/11/04 - Atual	Lecture Ciência Viva: "Células Estaminais e Medicina Regenerativa"	Biology (Ensino secundário)
2020/11/24 - Atual	Lecture on "Reversing the aging epigenotype during iPSC Reprogramming"	Aging and Dementia (Doutoramento)	Universidade de Aveiro, Portugal
2020/03/02 - Atual	Lecture on "Epigenetic regulation of gene expression: the classical examples of X-chromosome inactivation and genomic imprinting", Lisbon BioMed PhD Program.	(Doutoramento)	Instituto de Medicina Molecular, Portugal
2019/05/07 - Atual	Lecture on "Epigenetics and Gene Expression. Joint PhD program in Biomedicine" , IBIMED/Aveiro and Nova Medical School/Lisbon, Aveiro, Portugal, 7 May, 2019.	Biomedecine (Doutoramento)	Universidade de Aveiro Instituto de Biomedicina, Portugal
2018/09/15 - Atual	Member of the faculty team of the Course on “Molecular and Cellular Biology”, Integrated Master’s course in Nutrition Sciences, Faculty of Medicine of the University of Lisbon.	Molecular and Cellular Biology (Mestrado integrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2018/02/27 - Atual	Lecture on "Epigenetic stability and long non-coding RNAs in stem cell biology"	Frontiers in Biology Research (Mestrado)	Universidade de Lisboa Faculdade de Ciências, Portugal
2017 - Atual	Lecture on “Epigenetics and Obesity” for the Pediatrics Module, Integrated Master’s course in Medicine, Faculty of Medicine of the University of Lisbon	Pediatrics Module (Mestrado integrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2019/04/27 - 2019/04/27	Lecture on "Sustentabilidade e edição genética – desafios para a Biologia no século XXI" at IX Congresso Associação Portuguesa de Professores de Biologia e Geologia (APPBG)	(Pós-Graduação)
2017/07/15 - 2017/07/30	Optional Course on “Introduction to scientific investigation of molecular biology of the cell”, Integrated Master’s course in Medicine, Faculty of Medicine of the University of Lisbon, 2017/2018.	Optional Course on “Introduction to scientific investigation of molecular biology of the cell”, (Mestrado integrado)	Universidade de Lisboa Faculdade de Arquitectura, Portugal
2017/07/27 - 2017/07/27	Lecture on "The epigenetics of X-inactivation"	Module of epigenomics of metabolic disease of the doctoral program on Metabolism - . – clinics and experimentation (Doutoramento)	Universidade do Porto Faculdade de Medicina, Portugal
2016/04/21 - 2016/04/21	Lecture on "X-inactivation - a paradigm of epigenetic regulation mediated by the Xist long non-coding RNA"	Postgraduate Course on Epigenetics – from mechanisms to disease. (Pós-Graduação)	Universidade do Minho Escola de Medicina, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2025	Interview for the Jornal Diferencial, a student-run newspaper of Instituto Superior Técnico, about the 2024 Nobel Prize in Physiology or Medicine awarded for the discovery of microRNAs and its role in post-transcriptional gene regulation.	Diferencial

Membro de associação

	Nome da associação	Tipo de participação
2024 - Atual	Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC)	Coordinator of the “Cellular Therapies and Tissue Engineering” section
2022 - Atual	ISSCR – International Society for Stem Cell Research	Member

Revisão ad hoc de artigos em revista

	Nome da revista (ISSN)	Editora
2024 - Atual	Nature Communications (2041-1723)	Springer Nature
2024 - Atual	Nature Structural and Molecular Biology (1545-9985)	Springer Nature
2024 - Atual	Stem Cell Reports (2213-6711)	Cell Press
2024 - Atual	Clinical Epigenetics (1868-7083)	Springer Nature
2023 - Atual	Nucleic Acids Research (1362-4962)	Oxford University Press (OUP)
2023 - Atual	Nature Protocols (1750-2799)	Springer Nature
2022 - Atual	eLIFE (2050-084X)	eLife Sciences Publications Ltd.

Distinções

Prémio

2006	Best oral presentation at Rank Prize Mini-Symposium in Nutrigenomics, Windermere, UK Rank Prize Funds, Reino Unido
2001	Fundação Eng. António de Almeida Award for best ranking in the Biology Degree (1997/2001) Fundação Engenheiro António de Almeida, Portugal
2000	Manuel Ferreira Award for best performance in Vascular Taxonomy (1999/2000) Universidade do Porto, Portugal
1999	António Leitão Award for best performance in Plant Anatomy (1998/1999) Universidade do Porto, Portugal