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Jorge Salvador has a degree in Pharmaceutical Sciences, (University of Coimbra) a master¿s degree in Organic & Technological Chemistry, (New University of Lisbon) and a Ph.D. in Pharmacy-Pharmaceutical Chemistry (University of Coimbra in collaboration with the University of York, U.K.). He spent one year as a Postdoc student at the University of Sussex, UK. Post-grad. (1-year certif.) Cancer Biology & Therapeutics-HICR from Harvard-Medical School, University of Harvard, USA. He has a position as Full Professor at the Faculty of Pharmacy of the University of Coimbra ¿ Portugal and is a Non-Executive Member of the Board of CHEM4PHARMA, a start-up Pharmaceutical Company located in Portugal. Group leader of the research group ¿ Medicinal Chemistry & Drug Discovery¿ at Center for Neuroscience and Cell Biology (CNC) at the University of Coimbra, Portugal. His research group activity has been focused on studies of new semisynthetic steroid, diterpenoid, and triterpenoid derivatives with improved antitumor activity and investigation of their mechanisms of anticancer action. In addition, the discovery of novel PARP-1 inhibitors able to reverse anticancer chemoresistance and to sensitize cancer cells to chemotherapy is another line of research. Furthermore, enzyme inhibitors able to tackle hormone-dependent cancers, such as 5alpha-reductase and CYP17 inhibitors on prostatic cancer, are pursued in the group as well as new anticancer drugs acting on the ubiquitin-proteasome system (UPS). The green pharmaceutical processes, aiming to reach target molecules in a more efficient, eco-friendly and cheaper manner are continuously pursued in the group. Recently, he has been involved in studies on pharmacophore and structure-based drug discovery for the rational design of lead compounds inhibitors of BACE1 and Glutaminyl Cyclase for Alzheimer¿s disease treatment. He has edited 2 books and published more than 100 SCI journal papers, 16 book chapters and, 10 patents (2US Patents granted). In addition, he is the author/co-author of more than 250 presentations in national and international conferences and workshops. Supervisor of 4 pos-doc students, 18 PhD students (14 concluded; 4 ongoing), and > 40 MSc students. Over the last years, he has conducted several research projects in the field of pharmaceutical/medicinal chemistry which has contributed to his significant expertise in drug discovery. -Member of evaluation committees from Fundação para a Ciência e a Tecnologia (FCT), the Portuguese Research Council and other international funding agencies (National Science Centre, Poland, Swiss National Science Foundation, Research Foundation-Flanders, Belgian, France, Argentine, Brazil, among others) -Member of evaluation committees from A3ES. -Reviewer of the European Research Council, ERC Advanced Grants. - Arbitral Tribunal expert, (Industrial protection). 2014-Member of the Board of Directors of the MedChemTrain Ph.D. program, Univ. Coimbra. 2015-Coordinator of the Master in Medicinal Chemistry. 2010-2017 Coordinator of the Master in Industrial Pharmaceutical Chemistry. 2016-Director of the Mass Spectrometry Unity, University of Coimbra. 2015-Editorial Advisory Board of Current Green Chemistry. 2019-Guest Editor of Frontiers in Oncology. 2020-Editorial Board, Molecules, Medicinal Chemistry Section.
Identificação

Identificação pessoal

Nome completo
JORGE ANTÓNIO RIBEIRO SALVADOR

Nomes de citação

  • SALVADOR, J.A.R.
  • Jorge A. R. Salvador, Salvador, J.

Identificadores de autor

Ciência ID
1112-4DB1-C082
ORCID iD
0000-0003-0779-6083
Google Scholar ID
https://scholar.google.pt/citations?user=w6fpgvYAAAAJ&hl=en
Researcher Id
N-7174-2017
Scopus Author Id
ID: 7101616974

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2019/10/26
Concluído
Cancer Biology & Therapeutics-HICR (1 year cert.) (Pós-Graduação)
Harvard Medical School, Estados Unidos
2006/01/11
Concluído
Habilitation, Pharmaceutical Chemistry (Título de Agregado)
Universidade de Coimbra, Portugal
2001/10/01
Concluído
University of Sussex, Department of Chemistry (Pós-doutoramento)
University of Sussex, Reino Unido
1998/01/20
Concluído
Doutoramento em Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra, Portugal
"Reacções de Oxidação com Reagentes em Suportes Sólidos Usando Esteróides como Substratos" (TESE/DISSERTAÇÃO)
Muito Bom com distinção e louvor por unanimidade
1992/11/23
Concluído
Mestrado em Química Orgânica e Tecnológica (Mestrado)
Universidade Nova de Lisboa Departamento de Química, Portugal
"Aplicação de Ultra-Sons a Reacções com Zinco em Esteróides" (TESE/DISSERTAÇÃO)
Muito Bom
1987/07/31
Concluído
Licenciatura em Ciências Farmacêuticas- Farmácia Industrial (Licenciatura)
Universidade de Coimbra, Portugal
16 valores
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2013/04/07 - Atual Professor Catedrático (Docente Universitário) Universidade de Coimbra, Portugal
2002/11/26 - 2013/04/06 Professor Associado (Docente Universitário) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
1998/01/21 - 2002/11/25 Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
1992/11/24 - 1998/01/20 Assistente (Docente Universitário) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
1999 - 2000/10/01 The Partial Synthesis of Some Biologically Active Steroids
1999-00
Bolseiro de Pós-Doutoramento
University of Sussex Department of Chemistry and Biochemistry, Reino Unido

Projeto

Designação Financiadores
2020 - 2023/12/31 Strategic Plan-Centro de Química de Coimbra Coimbra Chemistry Center
UIDB/00313/2020
Investigador
2020 - 2023/12/31 Strategic Plan-Center for Innovative Biomedicine and Biotechnology
UIDB/04539/2020
Investigador
2020 - 2023/12/31 Srategic Plan-Institute for Biomedical Imaging and Translational Research
UIDB/04950/2020
Investigador
2020 - 2023/12/31 Strategic Plan -Center for Innovative Biomedicine and Biotechnology
UIDP/04539/2020
Investigador
2020 - 2023/12/31 Strategic Plan-Coimbra Institute for Biomedical Imaging and Translational Research
UIDP/04950/2020
Investigador
2020 - 2023/12/31 Strategic Plan-Coimbra Chemistry Cente
UIDP/00313/2020
Investigador
2017 - 2021 Projects for the Development and Implementation of Research Infrastructures inserted in the ESFRI. National Mass Spectrometry Network. UC node .
RNEM POCI-01-0145-FEDER-022125
Investigador responsável
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
2015 - 2020 Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery .
Ref: PTDC/QEQ-MED/7042/2014
Investigador
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2019/12/31 Drugs2CAD-Treatment of cancer and Alzheimer's diseases: discovering new drugs.
Ref. CENTRO-01-0247-FEDER-003269
Investigador responsável
Chem4pharma, Portugal
2012 - 2016 UC-NMR: A voyage from chemical space to biological Funtion.
RECI/QEQ-QFI/0168/2012
Investigador
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
2013 - 2014 Strategic Project - LA 1.
PEst-C/SAU/LA0001/2013
Investigador
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
2012 - 2014 Avaliação da Atividade Anticancerígena de Novos Triterpenóides Pentacíclicos:Estudo da Inibição da poli (ADP-ribose) polimerase (PARP-1).
MaisCentro-QREN
Investigador responsável
2011 - 2012 Avaliação da actividade anticancerígena de novos derivados do ácido oleanólico e do ácido ursólico: estudo da inibição do proteassoma.
MaisCentro-QREN
Investigador responsável
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2012 Avaliação da actividade anticancerígena de novos triterpenóides pentacíclicos de núcleo ursano: estudo da inibição do proteassoma.
MaisCentro-QREN
Investigador responsável
Universidade de Coimbra Faculdade de Farmácia, Portugal
2007 - 2008 Neuroactive Steroids: Synthesis and Studies on the Modulation of GABAA Receptor.
GRICES-ASCR (Czech Rep) 2007–2008
Investigador
Universidade de Coimbra Faculdade de Farmácia, Portugal
2002 - 2006 Cromatografia Líquida-Espectrometria de Massa na Análise de Compostos Bioactivos.
CONC-REEQ/850/2001
Investigador
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
2002 - 2006 Laboratório de Ressonância Magnética Nuclear de Alta Resolução em Moléculas Pequenas.
Ref: CONC-REEQ/ 481/2001
Investigador
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
2003 - 2005 Projecto para reforço das competências técnicas do IPN.
PRIME/MEDIDA B125
Investigador responsável
IPN - Instituto Pedro Nunes., Portugal
1998 - 2002 Catálise Estereoselectiva de Reacções de Hidroformilação e Hidrogenação por Transferência de Hidrogénio de Olefinas pró-quirais. Preparação de Produtos com Interesse Farmacológico.
PRAXIS XXI/P/QUI/10008/98
Investigador
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
1998 - 2000 A Síntese Química e a Sociedade. Fármacos e Saúde
CIÊNCIA VIVA-PIII-475
Investigador
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
1993 - 1997 Organic Synthetic Applications, programa de Química de Cooperação Europeia em Investigação Científica e Técnica, COST D6.
D6/0008/93 COST D6
Bolseiro de Doutoramento
Universidade de Coimbra Faculdade de Farmácia, Portugal
Produções

Publicações

Artigo em conferência
  1. J.Sousa; R. Brito; Jorge A R Salvador; C. Silva. "In Search of Predictive Models for Inibitors of 5-a-reductase 2". Trabalho apresentado em Proceedings, IWBBIO, 2014.
  2. Leal, Ana S.; Salvador, Jorge A.R.; Yongkui, Jing. "Abstract A23: Novel ursolic acid derivatives with potent antitumor activity". Trabalho apresentado em AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations, Boston, 2012.
    10.1158/1538-7445.csb12-a23
  3. Leal, Ana S.; Salvador, Jorge; Jing, Yongkui. "Abstract 4234: Ursolic acid induces apoptosis in pancreatic cancer cells associated with inhibition of STAT3 and down-regulation of Bcl-XL". 2011.
    10.1158/1538-7445.am2011-4234
  4. Moreira, V.M.A.; Jorge A.R.Salvador; Sá e Melo, M.L.; Hanson, J. R.; Marques, A.; Simões, S.. "New 5b,6b-epoxysteroids with cytotoxic activity". 2005.
  5. Salvador, J. A. R.; Sá e Melo, M.L.; Campos Neves, A. S.. "Ultrasound Assisted Oxidations with Potassium Permanganate on Solids Supports". Trabalho apresentado em 1995 World Congress of Ultrasonics, Berlin, 1995.
Artigo em revista
  1. Coimbra, Judite RM; Salvador JAR (1112-4DB1-C082). "A Patent Review of Glutaminyl Cyclase Inhibitors (2004-present).". (2021):
    Aceite para publicação
  2. Kok, Victor C.; Yu, Cheng-Chia; Salvador, Jorge A.R.. "Editorial: Head & Neck Cancer and Esophageal Cancer: From Biosignatures to Therapeutics". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.666103.
    Acesso aberto • Publicado • 10.3389/fonc.2021.666103
  3. Gütschow, Michael; Vanden Eynde, Jean Jacques; Jampilek, Josef; Kang, CongBao; Mangoni, Arduino A.; Fossa, Paola; Karaman, Rafik; et al. "Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes 7". Molecules 25 13 (2020): 2968. http://dx.doi.org/10.3390/molecules25132968.
    10.3390/molecules25132968
  4. Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al. "New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer’s Disease Models". Journal of Alzheimer's Disease (2020): 1-21. http://dx.doi.org/10.3233/jad-200381.
    10.3233/jad-200381
  5. Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R.. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors". Biomolecules 10 4 (2020): 535. http://dx.doi.org/10.3390/biom10040535.
    10.3390/biom10040535
  6. Pinto, Patricia; Machado, Carmen Mariana; Moreira, Joana; Almeida, José Diogo P.; Silva, Patrícia M.A.; Henriques, Ana C.; Soares, José X.; et al. "Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity". European Journal of Medicinal Chemistry 184 (2019): 111752. http://dx.doi.org/10.1016/j.ejmech.2019.111752.
    10.1016/j.ejmech.2019.111752
  7. Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR. "An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease". Future Medicinal Chemistry 11 24 (2019): 3179-3194. http://dx.doi.org/10.4155/fmc-2019-0163.
    10.4155/fmc-2019-0163
  8. Guedes, R.; Aniceto; Andrade; Salvador, J.A.R.. "Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design". International Journal of Molecular Sciences 20 21 (2019): 5326. http://dx.doi.org/10.3390/ijms20215326.
    10.3390/ijms20215326
  9. Alho, Daniela P.S.; Salvador, Jorge A.R.; Cascante, Marta; Marin, Silvia. "Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives". Molecules 24 16 (2019): 2938. http://dx.doi.org/10.3390/molecules24162938.
    10.3390/molecules24162938
  10. Valdeira, Ana S. C.; Darvishi, Emad; Woldemichael, Girma M.; Beutler, John A.; Gustafson, Kirk R.; Salvador, Jorge A. R.. "Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation". Journal of Natural Products 82 8 (2019): 2094-2105. http://dx.doi.org/10.1021/acs.jnatprod.8b00864.
    10.1021/acs.jnatprod.8b00864
  11. Alho, Daniela; Salvador, Jorge; Cascante, Marta; Marin, Silvia. "Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives". Molecules 24 4 (2019): 766. http://dx.doi.org/10.3390/molecules24040766.
    10.3390/molecules24040766
  12. Acúrcio, Rita C.; Leonardo-Sousa, Carlota; García-Sosa, Alfonso T.; Salvador, Jorge A.; Florindo, Helena F.; Guedes, Rita C.. "Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition". MedChemComm 10 10 (2019): 1810-1818. http://dx.doi.org/10.1039/c9md00326f.
    10.1039/c9md00326f
  13. Valdeira, Ana S. C.; Ritt, Daniel A.; Morrison, Deborah K.; McMahon, James B.; Gustafson, Kirk R.; Salvador JAR (1112-4DB1-C082). "Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling". Frontiers in Chemistry 6 (2018): http://dx.doi.org/10.3389/fchem.2018.00434.
    10.3389/fchem.2018.00434
  14. Acúrcio, Rita C.; Scomparin, Anna; Conniot, João; Salvador, Jorge A. R.; Satchi-Fainaro, Ronit; Florindo, Helena F.; Guedes, Rita C.. "Structure–Function Analysis of Immune Checkpoint Receptors to Guide Emerging Anticancer Immunotherapy". Journal of Medicinal Chemistry 61 24 (2018): 10957-10975. http://dx.doi.org/10.1021/acs.jmedchem.8b00541.
    10.1021/acs.jmedchem.8b00541
  15. Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia M. F.; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.; Salvador, Jorge A. R.. "Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment". Frontiers in Chemistry 6 (2018): http://dx.doi.org/10.3389/fchem.2018.00178.
    10.3389/fchem.2018.00178
  16. Baptista, Salete J.; Silva, Maria M. C.; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio; Dinis, Teresa C. P.; Salvador, Jorge A. R.. "Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach". PLOS ONE 12 1 (2017): e0170846. http://dx.doi.org/10.1371/journal.pone.0170846.
    10.1371/journal.pone.0170846
  17. Figueiredo, S.A.C.; Salvador, J.A.R.; Cortés, R.; Cascante, M.. "Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation". European Journal of Medicinal Chemistry 138 (2017): 422-437. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021775494&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.06.029
  18. Salvador, J.A.R.; Leal, A.S.; Valdeira, A.S.; Gonçalves, B.M.F.; Alho, D.P.S.; Figueiredo, S.A.C.; Silvestre, S.M.; Mendes, V.I.S.. "Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment". European Journal of Medicinal Chemistry 142 (2017): 95-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025822828&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.07.013
  19. Figueiredo, S.A.C.; Salvador, J.A.R.; Cortés, R.; Cascante, M.. "Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds". European Journal of Medicinal Chemistry 139 (2017): 836-848. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028462538&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.08.058
  20. Mendes, V.I.S.; Bartholomeusz, G.A.; Ayres, M.; Gandhi, V.; Salvador, J.A.R.. "Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells". European Journal of Medicinal Chemistry 123 (2016): 317-331. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979776393&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.07.045
  21. Gonçalves, B.M.F.; Salvador, J.A.R.; Santos, D.S.M.; Marín, S.; Cascante, M.. "Design, synthesis, and biological evaluation of novel asiatic acid derivatives as potential anticancer agents". RSC Advances 6 45 (2016): 39296-39309. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968807179&partnerID=MN8TOARS.
    10.1039/c6ra04597a
  22. Mendes, V.I.S.; Bartholomeusz, G.A.; Ayres, M.; Gandhi, V.; Salvador, J.A.R.. "Erratum: Corrigendum to “Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells” (European Journal of Medicinal Chemistry (2016) 123 (317–331) (S0223523416306067) (10.1016/j.ejmech.2016.07.045))". European Journal of Medicinal Chemistry 124 (2016): 1004-1005. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992431127&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.09.088
  23. Guedes, R.A.; Serra, P.; Salvador, J.A.R.; Guedes, R.C.. "Computational approaches for the discovery of human proteasome inhibitors: An overview". Molecules 21 7 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84979205213&partnerID=MN8TOARS.
    10.3390/molecules21070927
  24. Gonçalves, B.M.F.; Salvador, J.A.R.; Marín, S.; Cascante, M.. "Synthesis and biological evaluation of novel asiatic acid derivatives with anticancer activity". RSC Advances 6 5 (2016): 3967-3985. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954305589&partnerID=MN8TOARS.
    10.1039/c5ra19120c
  25. Gonçalves, B.M.F.; Salvador, J.A.R.; Marín, S.; Cascante, M.. "Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives". European Journal of Medicinal Chemistry 114 (2016): 101-117. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964200014&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.02.057
  26. Salvador, Jorge; Pinto, Rui; Silvestre, Samuel. "Pharmaceutical Green Chemistry Applied to the Chemical Synthesis of Steroid Compounds". Current Green Chemistry 2 2 (2015): 97-134. http://dx.doi.org/10.2174/2213346101666140915212302.
    10.2174/2213346101666140915212302
  27. Mesquita, L.M.M.; Pinto, R.M.A.; Salvador, J.A.R.; Clark, J.H.; Budarin, V.L.. "Starbon®400-HSO3: A green mesoporous carbonaceous solid acid catalyst for the Ritter reaction". Catalysis Communications 69 (2015): 170-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84933040279&partnerID=MN8TOARS.
    10.1016/j.catcom.2015.06.010
  28. Lopes, S.M.M.; Correia, C.F.O.; Nunes, S.C.C.; Pereira, N.A.M.; Ferreira, A.R.F.; Sousa, E.P.; Gomes, C.S.B.; et al. "Synthesis of chiral hexacyclic steroids via [8p + 2p] cycloaddition of diazafulvenium methides". Organic and Biomolecular Chemistry 13 34 (2015): 9127-9139. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939605321&partnerID=MN8TOARS.
    10.1039/c5ob01110h
  29. Sousa, M.C.; Varandas, R.; Santos, R.C.; Santos-Rosa, M.; Alves, V.; Salvador, J.A.R.. "Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: Synergistic effects with miltefosine". PLoS ONE 9 3 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84898670704&partnerID=MN8TOARS.
    10.1371/journal.pone.0089939
  30. Salvador, J.A.R.; Santos, R.C.; Figueiredo, S.A.C.; Jing, Y.. "Antitumor effects of celastrol and semi-synthetic derivatives". Mini-Reviews in Organic Chemistry 11 3 (2014): 400-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911413424&partnerID=MN8TOARS.
  31. Salvador, J.A.R.; Carvalho, J.F.S.; Neves, M.A.C.; Silvestre, S.M.; Leitão, A.J.; Silva, M.M.C.; Sá E Melo, M.L.. "Anticancer steroids: Linking natural and semi-synthetic compounds". Natural Product Reports 30 2 (2013): 324-374. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872556406&partnerID=MN8TOARS.
    10.1039/c2np20082a
  32. Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y.. "Synthesis of novel heterocyclic oleanolic acid derivatives with improved antiproliferative activity in solid tumor cells". Organic and Biomolecular Chemistry 11 10 (2013): 1726-1738. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874077386&partnerID=MN8TOARS.
    10.1039/c3ob00011g
  33. Moreira, V.M.; Salvador, J.A.R.; Simões, S.; Destro, F.; Gavioli, R.. "Novel oleanolic vinyl boronates: Synthesis and antitumor activity". European Journal of Medicinal Chemistry 63 (2013): 46-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878527939&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.01.040
  34. Salvador, J.A.R.; Pinto, R.M.A.; Silvestre, S.M.. "Steroidal 5a-reductase and 17a-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases". Journal of Steroid Biochemistry and Molecular Biology 137 (2013): 199-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886716946&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2013.04.006
  35. Salvador, J.A.R.; Moreira, V.M.; Pinto, R.M.A.; Leal, A.S.; Paixão, J.A.. "Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives". Beilstein Journal of Organic Chemistry 8 (2012): 164-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856902762&partnerID=MN8TOARS.
    10.3762/bjoc.8.17
  36. Salvador, J.A.R.; Silvestre, S.M.; Pinto, R.M.A.; Santos, R.C.; Leroux, C.. "New applications for bismuth(III) salts in organic synthesis: From bulk chemicals to steroid and terpene chemistry". Topics in Current Chemistry 311 (2012): 143-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856185934&partnerID=MN8TOARS.
    10.1007/128_2011_170
  37. Salvador, J.A.; Moreira, V.M.; Gonçalves, B.M.; Leal, A.S.; Jing, Y.. "Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs.". Natural product reports 29 12 (2012): 1463-1479. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872769330&partnerID=MN8TOARS.
  38. Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M.. "Recent developments in oxidative processes in steroid chemistry". Current Organic Chemistry 16 10 (2012): 1243-1276. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861178831&partnerID=MN8TOARS.
    10.2174/138527212800564204
  39. Salvador, J.A.; Figueiredo, S.A.; Pinto, R.M.; Silvestre, S.M.. "Bismuth compounds in medicinal chemistry". Future Medicinal Chemistry 4 11 (2012): 1495-1523. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864659112&partnerID=MN8TOARS.
    10.4155/fmc.12.95
  40. Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y.. "Semisynthetic Ursolic Acid Fluorolactone Derivatives Inhibit Growth with Induction of p21waf1 and Induce Apoptosis with Upregulation of NOXA and Downregulation of c-FLIP in Cancer Cells". ChemMedChem 7 9 (2012): 1635-1646. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865591129&partnerID=MN8TOARS.
    10.1002/cmdc.201200282
  41. Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y.. "Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells". Bioorganic and Medicinal Chemistry 20 19 (2012): 5774-5786. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866355871&partnerID=MN8TOARS.
    10.1016/j.bmc.2012.08.010
  42. Moreira, V.M.A.; Salvador, J.A.R.; Matos Beja, A.; Paixão, J.A.; Vasaitis, T.S.; Njar, V.C.O.. "C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells". European Journal of Pharmaceutical Sciences 44 (2011): 1-204. http://dx.doi.org/10.1016/j.ejps.2011.08.002.
    10.1016/j.ejps.2011.08.002
  43. Santos, R.C.; Salvador, J.A.R.; Cortés, R.; Pachón, G.; Marín, S.; Cascante, M.. "New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells". Biochimie 93 6 (2011): 1065-1075. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955054133&partnerID=MN8TOARS.
    10.1016/j.biochi.2011.02.014
  44. Salvador, J.A.R.; Moreira, V.M.; Pinto, R.M.A.; Leal, A.S.; Le Roux, C.. "Bismuth(III) triflate-based catalytic direct opening of oleanolic hydroxy-¿-lactones to afford 12-oxo-28-carboxylic acids". Advanced Synthesis and Catalysis 353 14-15 (2011): 2637-2642. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054739831&partnerID=MN8TOARS.
    10.1002/adsc.201100155
  45. Salvador, J.A.R.; Silvestre, S.M.; Pinto, R.M.A.. "Bismuth(III) reagents in steroid and terpene chemistry". Molecules 16 4 (2011): 2884-2913. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955528110&partnerID=MN8TOARS.
    10.3390/molecules16042884
  46. Moreira, V.M.; Salvador, J.A.R.; Beja, A.M.; Paixão, J.A.. "The reaction of azoles with 17-chloro-16-formylandrosta-5,16-dien-3ß- yl-acetate: Synthesis and structural elucidation of novel 16-azolylmethylene-17- oxoandrostanes". Steroids 76 6 (2011): 582-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954588573&partnerID=MN8TOARS.
    10.1016/j.steroids.2011.02.009
  47. Santos, R.C.; Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "3-Oxo-18a-olean-28,13ß-olide". Acta Crystallographica Section E: Structure Reports Online 66 8 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956829330&partnerID=MN8TOARS.
    10.1107/S160053681002903X
  48. Santos, R.C.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "3¿-Acet-oxy-lup-20(29)-en-28-yl 1H-1,2,4-tri-azole-1-carboxyl-ate". Acta Crystallographica Section E: Structure Reports Online 66 11 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78650948724&partnerID=MN8TOARS.
    10.1107/S1600536810043515
  49. Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.; Moreira, J.N.; Dinis, T.C.P.. "Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid". Bioorganic and Medicinal Chemistry 18 12 (2010): 4385-4396. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953321890&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.04.085
  50. Santos, R.C.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "3ß-Hydroxylup-20(29)-en-28-yl 1H-imidazole-1-carboxylate". Acta Crystallographica Section E: Structure Reports Online 66 7 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77954408228&partnerID=MN8TOARS.
    10.1107/S160053681002489X
  51. Moreira, V.M.; Salvador, J.A.R.. "The Multiple Effects of CYP17 Inhibitors on Prostate Cancer Cell.". Drugs of the Future 35 (2010): 71-72.
    10.1177/1758834016642370
  52. Santos, Rita C.; Salvador, Jorge A.R.; Marín, Silvia; Cascante, Marta; Moreira, João N.; Dinis, Teresa C.P.. "Synthesis and structure–activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid". Drugs of the Future 35 (2010): 240-241. http://dx.doi.org/10.1016/j.bmc.2010.04.085.
    10.1016/j.bmc.2010.04.085
  53. Santos, Rita C.; Salvador, Jorge A.R.; Marín, Silvia; Cascante, Marta. "Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity". Drugs of the Future 35 (2010): 246-247. http://dx.doi.org/10.1016/j.bmc.2009.07.050.
    10.1016/j.bmc.2009.07.050
  54. Salvador, J.A.R.; Pinto, R.M.A.; Santos, R.C.; Le Roux, C.; Beja, A.M.; Paixão, J.A.. "Bismuth triflate-catalyzed Wagner-Meerwein rearrangement in terpenes. Application to the synthesis of the 18a-oleanane core and A-neo-18a-oleanene compounds from lupanes". Organic and Biomolecular Chemistry 7 3 (2009): 508-517. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849131044&partnerID=MN8TOARS.
    10.1039/b814448f
  55. Ramos Silva, M.; Moreira, V.M.; Cardoso, C.; Beja, A.M.; Salvador, J.A.R.. "3-Oxoandrosta-4,6-dien-17ß-yl 2-methyl-1H-imidazole-1-carboxylate and 3-oxo-5-androst-17ß-yl 2-methyl-1H-imidazole-1-carboxyl-ate: C - H¿p and p-p Inter-molecular interactions". Acta Crystallographica Section C: Crystal Structure Communications 65 3 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-62149118592&partnerID=MN8TOARS.
    10.1107/S0108270109003278
  56. Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "6¿-Hydr-oxy-5¿-methyl-20-oxo-19-norpregn-9(10)-en-3¿-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 65 5 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-65549162802&partnerID=MN8TOARS.
    10.1107/S0108270109010233
  57. Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "16,17-Ep-oxy-5-hydr-oxy-6¿-nitrooxy-20-oxopregnan-3¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 65 6 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-67649854870&partnerID=MN8TOARS.
    10.1107/S1600536809016997
  58. Salvador, J.A.R.; Ppinto, R.M.A.; Silvestre, S.M.. "Recent advances of bismuth(III) salts in organic chemistry: Application to the synthesis of aliphatics, alicyclics, aromatics, amino acids and peptides, terpenes and steroids of pharmaceutical interest". Mini-Reviews in Organic Chemistry 6 4 (2009): 241-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350227226&partnerID=MN8TOARS.
    10.2174/157019309789371587
  59. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Paixão, J.A.. "Bismuth(III) triflate-catalyzed direct conversion of corticosteroids into highly functionalized 17-ketosteroids by cleavage of the C17-dihydroxyacetone side chain". Journal of Organic Chemistry 74 21 (2009): 8488-8491. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350736011&partnerID=MN8TOARS.
    10.1021/jo9018478
  60. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Carvalho, R.A.; Beja, A.M.; Paixão, J.A.. "Bismuth(III) triflate-catalyzed rearrangement of 16a,17a-epoxy-20-oxosteroids. Synthesis and structural elucidation of new 16a-substituted 17a-alkyl-17ß-methyl-¿13-18-norsteroids". Tetrahedron 65 31 (2009): 6169-6178. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649513263&partnerID=MN8TOARS.
    10.1016/j.tet.2009.05.043
  61. Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.. "Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity". Bioorganic and Medicinal Chemistry 17 17 (2009): 6241-6250. http://www.scopus.com/inward/record.url?eid=2-s2.0-68649104244&partnerID=MN8TOARS.
    10.1016/j.bmc.2009.07.050
  62. Santos, R.C.; Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "19¿,28-Epoxy-18a-olean-3¿-ol". Acta Crystallographica Section E: Structure Reports Online 65 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-70249125089&partnerID=MN8TOARS.
    10.1107/S1600536809030311
  63. Salvador, J.A.R.; Pinto, R.M.A.; Silvestre, S.M.. "Recent advances of nismuth(III) salts in organic chemistry: Application to the synthesis of heterocycles of pharmaceutical interest". Current Organic Synthesis 6 4 (2009): 426-470. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350110620&partnerID=MN8TOARS.
    10.2174/157017909789108701
  64. Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M.. "Catalytic epoxidation and syn-dihydroxylation reactions in steroid chemistry". Current Organic Chemistry 12 6 (2008): 492-522. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449108043&partnerID=MN8TOARS.
    10.2174/138527208784083897
  65. Moreira, V.M.; Salvador, J.A.R.; Vasaitis, T.S.; Njar, V.C.O.. "CYP17 inhibitors for prostate cancer treatment - An update". Current Medicinal Chemistry 15 9 (2008): 868-899. http://www.scopus.com/inward/record.url?eid=2-s2.0-44349099797&partnerID=MN8TOARS.
    10.2174/092986708783955428
  66. Pinto, R.M.A.; Salvador, J.A.R.; Paixão, J.A.. "5¿,6¿-Ep-oxy-17-oxoandrostan-3¿-yl acetate and 5¿,6¿-ep-oxy-20-oxo-pregnan-3¿-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 64 5 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-43149091878&partnerID=MN8TOARS.
    10.1107/S0108270108009621
  67. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Carvalho, R.A.; Silva, M.R.; Beja, A.M.; Paixão, J.A.. "Bismuth(III) salt-catalyzed Westphalen and "backbone" rearrangements of 5ß,6ß-epoxysteroids. Synthesis and structural elucidation of new olefinic 19-nor and 18,19-dinorsteroids". Steroids 73 5 (2008): 549-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-40649099519&partnerID=MN8TOARS.
    10.1016/j.steroids.2008.01.006
  68. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.. "Metal triflates combined with caffeine based imidazolium salts: A new family of highly efficient and reusable catalysts". Catalysis Communications 9 3 (2008): 465-469. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549069243&partnerID=MN8TOARS.
    10.1016/j.catcom.2007.07.022
  69. Leitão, A.J.L.; Salvador, J.A.R.; Pinto, R.M.A.; Sá e Melo, M.L.. "Hydrazine sulphate: a cheap and efficient catalyst for the regioselective ring-opening of epoxides. A metal-free procedure for the preparation of ß-alkoxy alcohols". Tetrahedron Letters 49 10 (2008): 1694-1697. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949187114&partnerID=MN8TOARS.
    10.1016/j.tetlet.2007.12.121
  70. Silva, M.R.; Moreira, V.M.; Cardoso, C.; Matos Beja, A.; Salvador, J.A.R.. "1H-Indazole and 2H-indazole derivatives of androsta-5,16-dien-3¿-ol". Acta Crystallographica Section C: Crystal Structure Communications 64 4 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-41849150404&partnerID=MN8TOARS.
    10.1107/S0108270108005842
  71. Pinto, R.M.A.; Salvador, J.A.R.; Paixão, J.A.; Matos Beja, A.; Ramos Silva, M.. "6¿-Chloro-5-hydroxy-20-oxopregnan-3¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 64 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-49149110097&partnerID=MN8TOARS.
    10.1107/S1600536808019478
  72. Silva, M.R.; Moreira, V.M.; Cardoso, C.; Matos Beja, A.; Salvador, J.A.R.. "Conformation of 17-chloro-16-formylandrosta-5,16-dien-3¿-yl acetate and 17-chloroandrosta-5,16-dien-3¿-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 64 9 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-51049095681&partnerID=MN8TOARS.
    10.1107/S0108270108025997
  73. Moreira, V.M.A.; Vasaitis, T.S.; Guo, Z.; Njar, V.C.O.; Salvador, J.A.R.. "Synthesis of novel C17 steroidal carbamates. Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth". Steroids 73 12 (2008): 1217-1227. http://www.scopus.com/inward/record.url?eid=2-s2.0-50249167090&partnerID=MN8TOARS.
    10.1016/j.steroids.2008.05.010
  74. Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "6¿-Acetamido-5-hydroxy-cholestan-3¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 64 12 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-57349122293&partnerID=MN8TOARS.
    10.1107/S160053680803568X
  75. Sanros R. C.; Cascante, M.; Salvador, J.A.R.. "Synthesis and Evaluation of Cytotoxic Activity of Novel Synthetic Lupane Derivatives". Drugs of the Future 33 (2008): 164.
    10.7324/rjc.2017.1041914
  76. Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "5a-Acetamido-6¿-hydroxy-17-oxoandrostan-3¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 63 7 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34547204638&partnerID=MN8TOARS.
    10.1107/S1600536807029893
  77. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.. "Bismuth(III) salts mediated regioselective ring opening of epoxides: an easy route to halohydrins and ß-hydroxy nitrates". Tetrahedron 63 37 (2007): 9221-9228. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547515937&partnerID=MN8TOARS.
    10.1016/j.tet.2007.06.054
  78. Ramos Silva, M.; Matos Beja, A.; Moreira, V.M.; Santos, R.C.; Salvador, J.A.R.. "3-Oxoandrost-4-en-17¿-yl 1H-imidazole-1-carboxyl-ate". Acta Crystallographica Section E: Structure Reports Online 63 12 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-36849032339&partnerID=MN8TOARS.
    10.1107/S1600536807057625
  79. Moreira, V.M.A.; Vasaitis, T.S.; Njar, V.C.O.; Salvador, J.A.R.. "Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors". Steroids 72 14 (2007): 939-948. http://www.scopus.com/inward/record.url?eid=2-s2.0-35349005731&partnerID=MN8TOARS.
    10.1016/j.steroids.2007.08.004
  80. Silvestre, S.M.; Salvador, J.A.R.. "Allylic and benzylic oxidation reactions with sodium chlorite". Tetrahedron 63 11 (2007): 2439-2445. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846804403&partnerID=MN8TOARS.
    10.1016/j.tet.2007.01.012
  81. Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.. "5,6¿-Dihydroxy-cholestan-3¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 63 5 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-40649129062&partnerID=MN8TOARS.
    10.1107/S1600536807014705
  82. Salvador, J.A.R.; Moreira, V.M.; Hanson, J.R.; Carvalho, R.A.. "One-pot, high yield synthesis of a-ketols from ¿5- steroids". Steroids 71 3 (2006): 266-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-32144460142&partnerID=MN8TOARS.
    10.1016/j.steroids.2005.11.002
  83. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.. "Ritter reaction mediated by bismuth(III) salts: One-step conversion of epoxides into vic-acylamino-hydroxy compounds". Synlett 13 (2006): 2047-2050. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748278524&partnerID=MN8TOARS.
    10.1055/s-2006-949608
  84. Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M.. "Catalytic oxidative processes in steroid chemistry: Allylic oxidation, ß-Selective expoxidation, alcohol oxidation and remote functionalization reactions". Current Organic Chemistry 10 17 (2006): 2227-2257. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750593724&partnerID=MN8TOARS.
    10.2174/138527206778742641
  85. Moreira, V.M.A.; Salvador, J.A.R.; Sá e Melo, M.L.; Hanson, J.R.; Marques, A.; Simões, S.. "New 5b,6b-epoxysteroids with cytotoxic activity". Sci. Pharm. 73 8 (2005): 86.
  86. Salvador, J.A.R.; Leitão, A.J.L.; Sá E Melo, M.L.; Hanson, J.R.. "Hydrazine hydrate induced reductive cleavage of a,ß-epoxy ketones: An efficient procedure for the preparation of ß-hydroxy ketones". Tetrahedron Letters 46 7 (2005): 1067-1070. http://www.scopus.com/inward/record.url?eid=2-s2.0-12344252059&partnerID=MN8TOARS.
    10.1016/j.tetlet.2004.12.103
  87. Salvador, J.A.R.; Silvestre, S.M.. "Bismuth-catalyzed allylic oxidation using t-butyl hydroperoxide". Tetrahedron Letters 46 15 (2005): 2581-2584. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244343394&partnerID=MN8TOARS.
    10.1016/j.tetlet.2005.02.080
  88. Paixão, J.I.F.; Salvador, J.A.R.; Paixão, J.A.; Beja, A.M.; Silva, M.R.; Gonsalves, A.M.D'A.R.. "6ß-Azido-7a-hydroxy-17-oxo-5a-androstan-3ß-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 60 9 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-5144230345&partnerID=MN8TOARS.
    10.1107/S0108270104011989
  89. Silvestre, S.M.; Salvador, J.A.R.; Clark, J.H.. "ß-Selective epoxidation of ¿5-steroids by O 2 using surface functionalised silica supported cobalt catalysts". Journal of Molecular Catalysis A: Chemical 219 1 (2004): 143-147. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042797794&partnerID=MN8TOARS.
    10.1016/j.molcata.2004.04.034
  90. Paixão, J.I.F.; Salvador, J.A.R.; Paixão, J.A.; Matos Beja, A.; Ramos Silva, M.; Rocha Gonsalves, A.M.d'A.. "17-Oxo-5a-androst-6-en-3ß-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 60 1 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-1242265340&partnerID=MN8TOARS.
    10.1107/S0108270103026933
  91. Salvador, J.A.R.; Hanson, J.R.. "The solid-phase oxidation of steroidal alkenes with potassium permanganate and metal salts". Journal of Chemical Research 8 (2004): 513-516. http://www.scopus.com/inward/record.url?eid=2-s2.0-7644227114&partnerID=MN8TOARS.
  92. Paixão, J.I.F.; Salvador, J.A.R.; Gonsalves, A.M.d’A R.. "Synthesis of New Azidosteroids and Related Compounds as Potential Aromatase Inhibitors.". Drugs of the Future (2004): 225.
  93. Hanson, J.R.; Hitchcock, P.B.; Salvador, J.A.R.. "The conformation of the side chain of 21-alkylpregnanes". Journal of Chemical Research - Part S 9 (2003): 556-558. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346787610&partnerID=MN8TOARS.
  94. Salvador, J.A.R.; Hanson, J.R.. "The role of metal salts in a solid phase ß-selective epoxidation of ¿5-steroids with potassium permanganate". Journal of Chemical Research - Part S 11 (2002): 576-578. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036867876&partnerID=MN8TOARS.
  95. Salvador, J.A.R.; Clark, J.H.. "The allylic oxidation of unsaturated steroids by tert-butyl hydroperoxide using surface functionalised silica supported metal catalysts". Green Chemistry 4 4 (2002): 352-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-57249085588&partnerID=MN8TOARS.
    10.1039/b201500p
  96. Freixa, Z.; Pereira, M.M.; Bayón, J.Carles; Silva, A.M.S.; Salvador, J.A.R.; Beja, A.M.; Paixão, J.A.; Ramos, M.. "Diastereoselective hydroformylation of ¿4-steroids with rhodium-phosphite catalysts". Tetrahedron Asymmetry 12 7 (2001): 1083-1087. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035826557&partnerID=MN8TOARS.
    10.1016/S0957-4166(01)00191-4
  97. Salvador, J.A.R.; Clark, J.H.. "The allylic oxidation of unsaturated steroids by tert-butyl hydroperoxide using homogeneous and heterogeneous cobalt acetate". Chemical Communications 1 (2001): 33-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035819394&partnerID=MN8TOARS.
  98. Campos Neves, A.S.; Sá E Melo, M.L.; Moreno, M.J.S.M.; Tavares Da Silva, E.J.; Salvador, J.A.R.; Da Costa, S.P.; Martins, R.M.L.M.. "Improved syntheses of aromatase inhibitors and neuroactive steroids efficient oxidations and reductions at key positions for bioactivity". Tetrahedron 55 11 (1999): 3255-3264. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033105263&partnerID=MN8TOARS.
    10.1016/S0040-4020(98)01138-7
  99. Salvador, J.A.R.; E Melo, M.L.Sá.; Campos Neves, A.S.. "Copper-catalysed allylic oxidation of ¿5-steroids by t-butyl hydroperoxide". Tetrahedron Letters 38 1 (1997): 119-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342276132&partnerID=MN8TOARS.
    10.1016/S0040-4039(96)02231-9
  100. Salvador, J.A.R.; Sá E Melo, M.L.; Campos Neves, A.S.. "Oxidations with potassium permanganate - Metal sulphates and nitrates. ß-selective epoxidation of ¿5-unsaturated steroids". Tetrahedron Letters 37 5 (1996): 687-690. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030034598&partnerID=MN8TOARS.
    10.1016/0040-4039(95)02243-0
  101. Sáe Melo, M.L.; Moreno, M.J.S.M.; da Costa, S.C.P.; Salvador, J.A.R.; Neves, A.S.C.. "Ultrasound assisted oxidations and reductions in steroid synthesis". Ultrasonics - Sonochemistry 1 1 (1994): http://www.scopus.com/inward/record.url?eid=2-s2.0-0028392619&partnerID=MN8TOARS.
    10.1016/1350-4177(94)90024-8
  102. Sáe Melo, M.L.; Moreno, M.J.S.M.; Pereira da Costa, S.C.; Salvador, J.A.R.; Campos Neves, A.S.. "SC21 ultrasound assisted reactions in steroid synthesis". European Journal of Pharmaceutical Sciences 2 1-2 (1994): http://www.scopus.com/inward/record.url?eid=2-s2.0-43949158790&partnerID=MN8TOARS.
    10.1016/0928-0987(94)90103-1
  103. Salvador, J.A.R.; Sa Melo, E.M.L.; Campos Neves, A.S.. "Ultrasound assisted zinc reactions in synthesis. 1. Efficient reduction of enones". Tetrahedron Letters 34 2 (1993): 357-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027505351&partnerID=MN8TOARS.
    10.1016/S0040-4039(00)60587-7
  104. Salvador, J.A.R.; Sa Melo, E.M.L.; Campos Neves, A.S.. "Ultrasound assisted zinc reactions in synthesis. 2. A new Clemmensen-type reduction". Tetrahedron Letters 34 2 (1993): 361-362. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027391706&partnerID=MN8TOARS.
    10.1016/S0040-4039(00)60588-9
Capítulo de livro
  1. Cruz Silva, Maria Manuel; António Ribeiro Salvador, Jorge. "Introductory Chapter: Chemistry and Biological Activity of Steroids - Scope and Overview". In Chemistry and Biological Activity of Steroids. IntechOpen, 2020.
    10.5772/intechopen.88781
  2. Jorge A. R. Salvador; M.M.Silva. "Preface". In Chemistry and Biological Activity of Steroids, Preface/page i-Preface/page ii. Reino Unido: IntechOpen, 2020.
    Publicado • 10.1016/b978-1-85573-345-9.50003-0
  3. Salete J Baptista; Maria MC Silva; Jorge A.R.Salvador. "PARP-1 Mediated DNA Repair and its Inhibition by Small Molecules". 1-44. 2017.
    Publicado
  4. Jorge A. R. Salvador; M. Manuel C. Silva; Samuel M. Silvestre. "Recent Highligts in Green Oxidative Chemical Processes Applied to Steroid Chemistry". IN TECH, 2016.
  5. Salvador, J.A.R.; Leal, A.S.; Alho, D.P.S.; Gonçalves, B.M.F.; Valdeira, A.S.; Mendes, V.I.S.; Jing, Y.. "Highlights of pentacyclic triterpenoids in the cancer settings". 2014.
    10.1016/B978-0-444-63294-4.00002-4
  6. A. R. Salvador, Jorge; M. A. Pinto, Rui; M. Silvestre, Samuel. "Application of Bismuth(III) Reagents and Catalysts to the Synthesis of Heterocyclic Compounds of Pharmaceutical Interest". In Advances in Organic Synthesis, 64-181. BENTHAM SCIENCE PUBLISHERS, 2013.
    10.2174/9781608054756113040005
  7. R. Salvador, Jorge A.; M., Vania; M., Samuel. "Steroidal CYP17 Inhibitors for Prostate Cancer Treatment: From Concept to Clinic". In Advances in Prostate Cancer. InTech, 2013.
    10.5772/52290
  8. Salvador, J.A.R.; Pinto, R.M.A.; Silvestre, S.M.. "Highlights of bismuth (III) salts applications in the synthesis of compounds of pharmaceutical interest". 2012.
  9. Salvador, J.A.R.. "Preface". 2011.
  10. Salvador, J.A.R.; Leal, A.S.M.; Santos, R.C.. "Semisynthetic pentacyclic triterpenoids in the cancer setting: Oleanolic acid and its derivatives". 2011.
  11. Salvador, J.A.R.; Moreira, V.M.. "Semisynthetic pentacyclic triterpenoids in the cancer setting: Ursolic acid and its derivatives". 2011.
  12. R. Salvador, Jorge A.; M., Vania. "Highlights of Natural Products in Prostate Cancer Drug Discovery". In Prostate Cancer - From Bench to Bedside. InTech, 2011.
    10.5772/27401
  13. Salvador, J. A. R.; Silvestre, S. M.; Pinto, R. M. A.; Santos, R. C.; LeRoux, C.. "New Applications for Bismuth(III) Salts in Organic Synthesis: From Bulk Chemicals to Steroid and Terpene Chemistry". In Bismuth-Mediated Organic Reactions, 143-177. Springer Berlin Heidelberg, 2011.
    10.1007/128_2011_170
  14. Salvador, J.A.R.; Moreira, V.M.. "Natural products action on prostate cancer cell growth, signaling and survival". 2009.
  15. Jorge A. R. Salvador; Sá e Melo, M.L.; Campos Neves A. S.. "A New Clemmensen Reduction”, Preparation of 5a-Androstan-17ß-ol from 5a-Androstan-17ß-ol-3-one,". Plenum Press, 1998.
Livro
  1. Jorge A. R. Salvador; M. M. Silva. Chemistry and Biological Activity of Steroids. Reino Unido: IntechOpen. 2020.
    10.5772/intechopen.77331
  2. Salvador, J.A.R.. Pentacyclic triterpenes as promising agents in cancer. New York, Estados Unidos: Nova Science Publishers. 2011.
    Publicado

Propriedade Intelectual

Patente
  1. Jorge A. R. Salvador; Rita Santos; Marta Cascante Serratosa. 2015. "Triterpenoid Derivatives Usefull as Antiproliferative Agents". Estados Unidos.
  2. Jorge A. R. Salvador; Rita Santos; Marta Cascante Serratosa. 2012. "Derivados Triterpenóides úteis como agentes Antiproliferativos". Portugal.
  3. Jorge A. R. Salvador; Rita Santos; Marta Cascante. 2010. "Triterpenoid Derivatives and Their Use as Antiproliferative Agents".
  4. Jorge A. R. Salvador; Samuel M. Silvestre. 2009. "Processo para a Oxidação Alílica de Compostos Insaturados". Portugal.
  5. Jorge A. R. Salvador; Samuel M. Silvestre. 2008. "Processo para a Oxidação Alílica de Compostos Insaturados". Portugal.
  6. Jorge A. R. Salvador; Samuel M. Silvestre. 2006. "Processo para a Oxidação Alílica de Compostos Insaturados Usando Hidroperóxido de t-Butilo e Catalisadores de Bismuto". Portugal.
  7. Clark, J.H.; Jorge A. R. Salvador. 2002. "Cobalt Catalysed Allylic Oxidation of Unsaturated Steroids Using Alkyl Hydroperoxide". Austrália.
  8. CLARK, J.H; Jorge A. R. Salvador. 2002. "Cobalt Catalysed Allylic Oxidation of Unsaturated Steroids Using Alkyl Hydroperoxide".
  9. CLARK, J.H; Jorge A. R. Salvador. 2001. "Cobalt Catalysed Allylic Oxidation of Unsaturated Steroids Using Alkyl Hydroperoxide". Reino Unido.
  10. Jorge A.R.Salvador; M Luisa Sá e Melo; André S. Campos Neves. 2001. "Copper-Catalysed Allylic Oxidation Using Alkyl Hydroperoxide". Estados Unidos.
    Concedida/Emitida
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2020/10/01 - Atual Preparation of novel fluorinated ent-kaurane-type diterpenoid derivatives and evaluation of their antiproliferative activity.
Orientador
Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/10/01 - Atual Exploring the discovery of dual proteasome and CRM1 inhibitors in anticancer therapy
Orientador
Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/10/01 - Atual Novel abietane-type diterpenoid derivatives with potent anticancer activity
Orientador
Pharmaceutical Sciences: sub-area Pharmaceutical Chemistry (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/10/01 - Atual Rational Drug Design of Novel Potent multifunctional Agents for Alzheimer´s Disease Treatment
Orientador
Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10/01 - 2019/12/17 Targeting the proteasome in anticancer therapy by a computational based drug discovery approach
Coorientador
Pharmacy: sub-area Therapeutic and Pharmaceutical Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/10/01 - 2019/12/16 Discovery and development of novel small-molecule imune system modulators
Coorientador
Pharmacy: sub-area Therapeutic and Pharmaceutical Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/11/01 - 2019/12/11 Preparation and preclinical evaluation of new ursane-type triterpenoids
Orientador
Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra, Portugal
2011/10/01 - 2018/06/12 Rational design, synthesis and evaluation of novel anticancer chemopotentiators acting on DNA-repair pathways
Orientador
Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra, Portugal
2012/10/01 - 2017/12/19 Pentacyclic Triterpenoids: Discovery of New Drugs with Antitumour Activity
Orientador
Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra, Portugal
2014/10/01 - 2017/03/03 Preparation of New Bioactive Flavonoids Derivatives
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10/01 - 2017/03/03 New Chiral Steroid Derivatives Through (8p+2p)” Cycloaddition Reactions of 1,2 Diazafulvenium Methines,
Orientador
Química Farmacêutica Industrial (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10/01 - 2017/03/03 Designing and Preparation of New BACE1 Inhibitors for Alzheimer´s Disease Treatment
Orientador
Química Farmacêutica Industrial (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10/01 - 2017/03/03 Síntese de Triterpenóides Fluorados
Orientador
Química Farmacêutica Industrial (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/11/01 - 2016/11/24 Preparation and Pre-clinical Evaluation of New Pentacyclic Triterpenoids
Orientador
Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra, Portugal
2010/11/01 - 2016/11/24 Preparação e avaliação pré-clínica de novos compostos triterpenóides.
Orientador
Pharmaceutical Sciences: sub-area Pharmaceutical Chemistry (Doutoramento)
Universidade de Coimbra, Portugal
2014/10/01 - 2016/10/20 Synthesis of Bioactive Chalcones and their Heterocyclic Derivatives as Potential Antitumor Agents
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10/01 - 2016/10/20 Synthesis of Marine Xanthones : tracking Yicathins B and C
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/10/01 - 2016/10/01 Síntese de derivados semi-sintéticos do ácido oleanólico com vista à actividade antitumoral
Orientador
Medicinal Chemistry (Mestrado)
Universidade de Coimbra, Portugal
2014/10/01 - 2016/09/03 Análise de Fitoquímicos em geranium Robertianum L
Coorientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/10/01 - 2015/07/28 Preparação de Triterpenóides e Avaliação da Atividade Antiparasitária em Tripanossomatideo leishmania infantum
Coorientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009/11/01 - 2015 Preparação e avaliação anti-tumoral de novos triterpenóides de núcleo oleanano
Orientador
Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra, Portugal
2012/10/01 - 2014/10/14 Study of the Impact of Pollutant Compounds and Oxidative Stress in Human Health
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/10/01 - 2014/09/30 Preparação de Novos derivados de Esteróides através de Cicloadição [8p+2p] de aniões 1,2 Diazafulvénio
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/10/01 - 2014/09/30 Prospecção e Obtenção de Compostos com Potencial Terapêutico, a partir de Subprodutos Industriais
Coorientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/10/01 - 2014/09/29 Comparação de Métodos de Fingerprints para o Rastreio Virtual de inhibidores da 5a-Redutase
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/10/01 - 2013/10/31 Modificações Estruturais em Compostos Triterpenóides
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/10/01 - 2013/10/15 Preparação de Novos Derivados Esteróides via Reações de Cicloadições Dipolares
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2013/10/15 Novos Processos de Fluoração em Química Farmacêutica Industrial
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/10/01 - 2013/10/14 Rastreio Virtual na Descoberta de Possíveis Inibidores da 5-a-Redutase
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2013/09/17 Virtual Screening e Avaliação Biológica de Novos Inibidores do Proteassoma
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2007/11/01 - 2013/02/19 Preparação e avaliação pré-clínica de novos triterpenos derivados dos ácidos oleanólico e ursólico
Orientador
Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra, Portugal
2010/10/01 - 2013/02/08 New Sustainable Processes Catalyzed by Acids with Pharmaceutical Interest
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2013/02/07 Derivatização de Esteróides Assistida por Micro-ondas
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2013/02/06 Semi-síntese de Novos Derivados Flavonóides Bioactivos. Estudo de Reacções de Acilação e Desacilação Regiosselectivas Recorrendo a Lipases como Catalisadores.
Coorientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2013/02/06 Caracterização Estrutural de Novos Triterpenóides Pentacíclicos
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/10/25 Marcadores de Neoplasia e de Infecção por Vírus JC em Cólon Human.
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/10/16 Estudo Sistemático da Formação de Estrutura em Processos de Microencapsulação por Evaporação de Solvente
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/10/11 Monitorização da Cinética de Formação de Microcápsulas usando uma Técnica de Dispersão de Luz
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/09/27 Tratamento de Efluentes Líquidos da Indústria Farmacêutica pelo Processo de Fenton
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/09/26 Modificações Estruturais de Compostos Polifenólicos Glicosidados e Modulação das suas Actividades Antioxidantes
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/09/24 Manufacturing Process and Quality Control of Solid Dosage Forms Optimization for the Pharmaceutical Industry by Near Infrared Spectroscopy and Chemometric Analysis
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/09/20 Preparação de novos Derivados Flavonóides com Potencial Actividade Biológica
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/09/17 Derivados Xantónicos Prenilados: Obtenção de Análogos Estruturais da a-Mangostina e Avaliação da Actividade Antitumoral
Orientador
Industrial Pharmaceutical Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2005/10/01 - 2011/05/04 Síntese e avaliação da citotoxicidade de novos compostos triterpénicos pentacíclicos do tipo lupano
Orientador
Pharmaceutical Sciences: sub-area Pharmaceutical Chemistry (Doutoramento)
Universidade de Coimbra, Portugal
2005/01/01 - 2010/03/29 Novos processos com reagentes e catalisadores de bismuto usando esteróides como substratos
Orientador
Pharmaceutical Sciences: sub-area Pharmaceutical Chemistry (Doutoramento)
Universidade de Coimbra, Portugal
2003/11/01 - 2008/06/05 Novos esteróides inibidores da biossíntese de androgéneos
Orientador
Pharmaceutical Sciences: sub-area Pharmaceutical Chemistry (Doutoramento)
Universidade de Coimbra, Portugal
2002/10/01 - 2007/03/26 Novos processos de oxidação ambientalmente aceitáveis usando esteróides como substratos
Orientador
Pharmaceutical Sciences- sub-area Pharmaceutical Chemistry (Doutoramento)
Universidade de Coimbra, Portugal
2002/10/01 - 2004/12/02 Síntese de Novos 6-Azidoesteróides Potenciais Inibidores da Aromatase
Orientador
Chemistry (Mestrado)
Universidade de Coimbra Departamento de Química, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020/02/01 - Atual Molecules-Section Medicinal Chemistry MDPI
2019 - Atual Frontiers in Oncology- Guest Associate Editor (2234-943X) Frontiers Media SA
2015 - Atual Current Green Chemistry (2213-3461) Bentham Science

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2021/02/24 - Atual Member of the evaluation committees Swiss National Science Foundation, Switzerland.
2020/12/15 - Atual -Reviewer of the European Research Council, ERC Advanced Grants. European Research Council
2020/12 - Atual -Member of evaluation committees from A3ES.
Membro
2018/05/25 - Atual Member of the evaluation committees Research Foundation-Flanders, Belgian,
2017 - Atual Member of the Evaluation Committee, Transnational Projects, Portugal-Brazil.
Membro
Universidade de Coimbra, Portugal Fundação para a Ciência e a Tecnologia
2017 - Atual Member of the Evaluation Committee, Transnational Projects, Portugal-Hungary.
Membro
Universidade de Coimbra, Portugal
2017 - Atual Member of the Evaluation Committee, Transnational Projects, Portugal-France.
Membro
Universidade de Coimbra, Portugal
2014/01/01 - Atual Member of the Evaluation Committee National Science Centre, Poland
Avaliador
2014 - Atual -Member of evaluation committees from Fundação para a Ciência e a Tecnologia (FCT), the Portuguese Research Council
Membro
Fundação para a Ciência e a Tecnologia
2016 - 2020 Board of Directors & Selection Comittee Member, MedChemTrain PhD program Fundação para a Ciência e a Tecnologia
Distinções

Prémio

2009 Award IAPMEI atribuído no Concurso de Ideias “Arrisca Coimbra 09”
Universidade de Coimbra, Portugal
2009 Award DNA-Saúde, Concurso de Ideias “Arrisca Coimbra 09
Universidade de Coimbra, Portugal
2009 1º Award CEBT do Curso de Empreendedorismo de Base Tecnológica (4ºEdição), Junho de 2009, atribuído ao projecto LEAD.
Universidade de Coimbra, Portugal
1987 Award "Sociedade Farmacêutica Lusitana" best student, Faculdades de Farmácia do Ramo Farmácia Industrial, Licenciatura 81/87.
Ordem dos Farmaceuticos, Portugal

Outra distinção

2013 O projecto de doutoramento envolvendo a estudante Vânia Maria Antunes Moreira (SFRH/BD/12508/2003.) continuado com o pos-doc (SFRH/BPD/45037/2008) foi seleccionado para difusão através da rede ATOMIUM CULTURE, Bringing Europe to the Forefront.
1999 Post-doc grant FUNDAÇÃO CALOUSTE GULBENKIAN na Universidade de Sussex (U.K.) durante o ano lectivo 1999/2000.
1989 MSc grant from INIC , 1989/90, processo nº28881
INIC, Portugal
1984 Lic. Grant from FUNDAÇÃO CALOUSTE GULBENKIAN, processo nº 179/84 (suspensão da Bolsa à data da entrada em exercício do contrato de monitor).