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Ana Loureiro completed her graduation in Biochemistry in 2008 by the University of Coimbra and the PhD in Doctoral Program in Molecular and Environmental Biology in 2015/12/11 by the University of Minho. Ana is Researcher in SOLFARCOS - Soluções Farmacêuticas e Cosméticas, Lda, where she is involved in the development of cosmetic and dermal pharmaceutical formulations for highly marketable products. Published 28 articles in journals. Supervised 2 MSc dissertations. Has received 2 awards. Participates and/or participated as Researcher in 7 projects (3 European projects). Works in the areas of Medical and Health Sciences with emphasis on Medical Biotechnology, Health-Related Biotechnology and Biomaterials; Engineering and Technology with emphasis on Nano-technology and Nano-materials; and Engineering and Technology with emphasis on Industrial Biotechnology, on Bio-derived Novel Materials. In their professional activities interacted with 81 collaborators co-authorship of scientific papers.
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Identificação

Identificação pessoal

Nome completo
Ana Loureiro

Nomes de citação

  • Loureiro, Ana

Identificadores de autor

Ciência ID
0D1C-DCA4-6938
ORCID iD
0000-0003-0758-4662
Researcher Id
B-8245-2016
Scopus Author Id
35574110800

Endereços de correio eletrónico

  • aloureiro@ceb.uminho.pt (Profissional)
  • ail@solfarcos.com (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
  • Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Novos Materiais de Bio-derivados

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1)
Formação
Grau Classificação
2015/12/11
Concluído
 Doctoral Program in Molecular and Environmental Biology (Doutoramento)
Especialização em Health and Cellular Biology
Universidade do Minho Escola de Ciências, Portugal
"Protein-based nanodevices for therapeutic applications" (TESE/DISSERTAÇÃO)
 Muito Bom
2012/05/11
Concluído
 Bionanosystems for Biomedical Application (Pós-Graduação)
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2010/06/22
Concluído
 Nanotechnologies applied to theranostics: from diagnosis to disease therapy (Pós-Graduação)
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2008
Concluído
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Formação de estruturas extracelulares por macrófagos activados" (TESE/DISSERTAÇÃO)
 16
2007/09/21
Concluído
 Host-fungus interactions and virulence (Pós-Graduação)
Universidade do Minho Departamento de Biologia, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/01/01 - Atual Investigador (Investigação) SOLFARCOS - Soluções Farmacêuticas e Cosméticas, Lda, Portugal
2016/01/01 - 2020/12/31 Pós-doutorado (Investigação) Universidade do Minho Centro de Engenharia Biológica, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2009/10/01 - 2015/12/11 PhD student Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2009/03/01 - 2009/09/30 Scholarship Research Universidade do Minho - Campus de Azurém, Portugal
2008/07/01 - 2008/07/01 Collaboration in classes of training program called Immunity and Disease Control Universidade do Minho, Portugal
2007/09/01 - 2008/07/01 Curricular traineeship Universidade do Minho Departamento de Biologia, Portugal
2008/04/01 - 2008/05/01 Collaboration in Immunology classes of the Master in Molecular Genetic Universidade do Minho, Portugal
2007/04/19 - 2007/04/19 Presence in Conference of Nanotechnology: "Nanotechnology Applications in Biomedicine area" Universidade de Coimbra, Portugal
2006/10/04 - 2006/10/04 Presence at the Seminar "Genome: Challenge for Engineering" Universidade de Coimbra, Portugal
2005/11/26 - 2005/11/26 Presence at the XVI Meeting of the Portuguese Society of Hemorheology and Microcirculation "Hemorheology, microcirculation and Oxidative Stress" Universidade de Coimbra, Portugal
2005/11/21 - 2005/11/21 Presence at the Seminar "One day of Forensic Anthropology" Universidade de Coimbra, Portugal
Projetos

Bolsa

Designação Financiadores
2020/01/01 - 2020/12/31 Strategic Funding 2020-2023
PEst UIDB/04469/2020
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2016/01/01 - 2019/12/31 FOLSMART European Project - Folate-target nanodevices to activated macrophages for rheumatoid arthritis
Grant agreement no.: 683356
Investigador
EU Framework Programme for Research and Innovation Nanotechnologies Advanced Materials Advanced Manufacturing and Processing and Biotechnology
Em curso
2017/05 - 2017/12 Strategic Funding 2015-2018
UID/BIO/04469/2013 (POCI-01-0145-FEDER-006684)
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2009/12 - 2013/11 NANOFOL European Project - Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases
Grant agreement no.: 228827-2
Investigador
FP7 Nanosciences Nanotechnologies Materials and New Production Technologies
Concluído
2009/03 - 2009/11 LIDWINE European Project - Multifunctional Medical Textiles for wound (e.g. Decubitus) prevention and improved wound healing
Grant agreement no.: 026741
Investigador
European Commission Sixth Framework Programme
Concluído

Projeto

Designação Financiadores
2020/01/01 - 2023/06/30 RHAQ para a Solfarcos
NORTE-06-3559-FSE-000141 (Norte2020)
Investigador
Em curso

Outro

Designação Financiadores
2021/01/01 - 2022/10/31 KeraPep - Novos péptidos para reparar as propriedades do cabelo
NORTE-01-0247-FEDER-046919 (Portugal2020)
Investigador
Em curso
Produções

Publicações

Artigo em revista
  1. Sofia Moura; Jennifer Noro; Patrícia Cerqueira; Carla Silva; Artur Cavaco-Paulo; Ana Loureiro. "Poloxamer 407 based-nanoparticles for controlled release of methotrexate". International Journal of Pharmaceutics 575 (2020): 118924-118924. https://doi.org/10.1016/j.ijpharm.2019.118924.
    10.1016/j.ijpharm.2019.118924
  2. Guimarães, D.; Noro, J.; Loureiro, A.; Lager, F.; Renault, G.; Cavaco-Paulo, A.; Nogueira, E.. "Increased encapsulation efficiency of methotrexate in liposomes for rheumatoid arthritis therapy". Biomedicines 8 12 (2020): 1-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098654668&partnerID=MN8TOARS.
    10.3390/biomedicines8120630
  3. Patrícia Cerqueira; Jennifer Noro; Sofia Moura; Diana Guimarães; Carla Silva; Artur Cavaco-Paulo; Ana Loureiro. "PTS micelles for the delivery of hydrophobic methotrexate". International Journal of Pharmaceutics 566 (2019): 282-290. https://doi.org/10.1016/j.ijpharm.2019.05.049.
    10.1016/j.ijpharm.2019.05.049
  4. Tinoco, Ana; Sárria, Marisa P.; Loureiro, Ana; Parpot, Pier; Espiña, Begoña; Gomes, Andreia C.; Cavaco-Paulo, Artur; Ribeiro, Artur. "BSA/ASN/Pol407 nanoparticles for acute lymphoblastic leukemia treatment". Biochemical Engineering Journal 141 (2019): 80-88. http://dx.doi.org/10.1016/j.bej.2018.10.006.
    10.1016/j.bej.2018.10.006
  5. Guimarães, D.; Noro, J.; Loureiro, A.; Cavaco-Paulo, A.; Nogueira, E.. "Quantification of drugs encapsulated in liposomes by 1 H NMR". Colloids and Surfaces B: Biointerfaces 179 (2019): 414-420. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064269629&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2019.03.039
  6. Loureiro, A.; Pais, C.; Sampaio, P.. "Relevance of Macrophage Extracellular Traps in C. albicans Killing". Frontiers in Immunology 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077150034&partnerID=MN8TOARS.
    10.3389/fimmu.2019.02767
  7. Loureiro, A.; Noro, J.; Abreu, A.S.; Nogueira, E.; Soares Da Costa, D.; Silva, C.; Cavaco-Paulo, A.. "Absence of Albumin Improves in Vitro Cellular Uptake and Disruption of Poloxamer 407-Based Nanoparticles inside Cancer Cells". Molecular Pharmaceutics 15 2 (2018): 527-535. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041805740&partnerID=MN8TOARS.
    10.1021/acs.molpharmaceut.7b00893
  8. Nogueira, E.; Sárria, M.P.; Azoia, N.G.; Antunes, E.; Loureiro, A.; Guimarães, D.; Noro, J.; et al. "Internalization of Methotrexate Conjugates by Folate Receptor-a". Biochemistry 57 49 (2018): 6780-6786. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058313974&partnerID=MN8TOARS.
    10.1021/acs.biochem.8b00607
  9. Tinoco, A.; Gonçalves, J.; Silva, C.; Loureiro, A.; Gomes, A.C.; Cavaco-Paulo, A.; Ribeiro, A.. "Keratin-based particles for protection and restoration of hair properties". International Journal of Cosmetic Science 40 4 (2018): 408-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052808871&partnerID=MN8TOARS.
    10.1111/ics.12483
  10. Noro, J.; Loureiro, A.; Gonçalves, F.; Azoia, N.G.; Jung, S.; Silva, C.; Cavaco-Paulo, A.. "Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation". Colloids and Surfaces B: Biointerfaces 159 (2017): 259-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026861214&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2017.07.055
  11. Song, J.E.; Su, J.; Loureiro, A.; Martins, M.; Cavaco-Paulo, A.; Kim, H.R.; Silva, C.. "Ultrasound-assisted swelling of bacterial cellulose". Engineering in Life Sciences 17 10 (2017): 1108-1117. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026639094&partnerID=MN8TOARS.
    10.1002/elsc.201700085
  12. Su, J.; Noro, J.; Loureiro, A.; Martins, M.; Azoia, N.G.; Fu, J.; Wang, Q.; Silva, C.; Cavaco-Paulo, A.. "PEGylation Greatly Enhances Laccase Polymerase Activity". ChemCatChem 9 20 (2017): 3888-3894. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030450895&partnerID=MN8TOARS.
    10.1002/cctc.201700849
  13. Nogueira, E.; Freitas, J.; Loureiro, A.; Nogueira, P.; Gomes, A.C.; Preto, A.; Carmo, A.M.; Moreira, A.; Cavaco-Paulo, A.. "Neutral PEGylated liposomal formulation for efficient folate-mediated delivery of MCL1 siRNA to activated macrophages". Colloids and Surfaces B: Biointerfaces 155 (2017): 459-465. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019046361&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2017.04.023
  14. Martins, M.; Loureiro, A.; Azoia, N.G.; Silva, C.; Cavaco-Paulo, A.. "Protein Formulations for Emulsions and Solid-in-Oil Dispersions". Trends in Biotechnology 34 6 (2016): 496-505. http://www.scopus.com/inward/record.url?eid=2-s2.0-84977930107&partnerID=MN8TOARS.
    10.1016/j.tibtech.2016.03.001
  15. Loureiro, A.; Azoia, N.G.; Gomes, A.C.; Cavaco-Paulo, A.. "Albumin-based nanodevices as drug carriers". Current Pharmaceutical Design 22 10 (2016): 1371-1390. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961753027&partnerID=MN8TOARS.
  16. Nogueira, E.; Cruz, C.F.; Loureiro, A.; Nogueira, P.; Freitas, J.; Moreira, A.; Carmo, A.M.; et al. "Assessment of liposome disruption to quantify drug delivery in vitro". Biochimica et Biophysica Acta - Biomembranes 1858 2 (2016): 163-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948166510&partnerID=MN8TOARS.
    10.1016/j.bbamem.2015.11.008
  17. Nogueira, E.; Lager, F.; Le Roux, D.; Nogueira, P.; Freitas, J.; Charvet, C.; Renault, G.; et al. "Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice". Journal of Biomedical Nanotechnology 11 12 (2015): 2243-2252. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941551653&partnerID=MN8TOARS.
    10.1166/jbn.2015.2170
  18. Loureiro, A.; Nogueira, E.; Azoia, N.G.; Sárria, M.P.; Abreu, A.S.; Shimanovich, U.; Rollett, A.; et al. "Size controlled protein nanoemulsions for active targeting of folate receptor positive cells". Colloids and Surfaces B: Biointerfaces 135 (2015): 90-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938412704&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2015.06.073
  19. Loureiro, A.; Bernardes, G.J.L.; Shimanovich, U.; Sárria, M.P.; Nogueira, E.; Preto, A.; Gomes, A.C.; Cavaco-Paulo, A.. "Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors". Nanomedicine: Nanotechnology, Biology, and Medicine 11 5 (2015): 1077-1083. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931072074&partnerID=MN8TOARS.
    10.1016/j.nano.2015.02.022
  20. Loureiro, A.; Abreu, A.S.; Sárria, M.P.; Figueiredo, M.C.O.; Saraiva, L.M.; Bernardes, G.J.L.; Gomes, A.C.; Cavaco-Paulo, A.. "Functionalized protein nanoemulsions by incorporation of chemically modified BSA". RSC Advances 5 7 (2015): 4976-4983. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919754585&partnerID=MN8TOARS.
    10.1039/c4ra13802c
  21. Nogueira, E.; Mangialavori, I.C.; Loureiro, A.; Azoia, N.G.; Sárria, M.P.; Nogueira, P.; Freitas, J.; et al. "Peptide Anchor for Folate-Targeted Liposomal Delivery". Biomacromolecules 16 9 (2015): 2904-2910. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941584525&partnerID=MN8TOARS.
    10.1021/acs.biomac.5b00823
  22. Gonçalves, I.; Martins, M.; Loureiro, A.; Gomes, A.; Cavaco-Paulo, A.; Silva, C.. "Sonochemical and hydrodynamic cavitation reactors for laccase/hydrogen peroxide cotton bleaching". Ultrasonics Sonochemistry 21 2 (2014): 774-781. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888128653&partnerID=MN8TOARS.
    10.1016/j.ultsonch.2013.08.006
  23. Shimanovich, U.; Munder, A.; Loureiro, A.; Azoia, N.G.; Gomes, A.; Cavaco-Paulo, A.; Gedanken, A.; Gruzman, A.. "Gene silencing by siRNA nanoparticles synthesized via sonochemical method". Journal of Nanomedicine and Nanotechnology 5 3 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903490158&partnerID=MN8TOARS.
    10.4172/2157-7439.1000204
  24. Nogueira, E.; Loureiro, A.; Nogueira, P.; Freitas, J.; Almeida, C.R.; Härmark, J.; Hebert, H.; et al. "Liposome and protein based stealth nanoparticles". Faraday Discussions 166 (2013): 417-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887481690&partnerID=MN8TOARS.
    10.1039/c3fd00057e
  25. Kim, S.; Fernandes, M.M.; Matamá, T.; Loureiro, A.; Gomes, A.C.; Cavaco-Paulo, A.. "Chitosan-lignosulfonates sono-chemically prepared nanoparticles: Characterisation and potential applications". Colloids and Surfaces B: Biointerfaces 103 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869872993&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2012.10.033
  26. Fernandes, M.M.; Lima, C.F.; Loureiro, A.; Gomes, A.C.; Cavaco-Paulo, A.. "Keratin-based peptide: Biological evaluation and strengthening properties on relaxed hair". International Journal of Cosmetic Science 34 4 (2012): 338-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863723205&partnerID=MN8TOARS.
    10.1111/j.1468-2494.2012.00727.x
  27. Rollett, A.; Reiter, T.; Nogueira, P.; Cardinale, M.; Loureiro, A.; Gomes, A.; Cavaco-Paulo, A.; et al. "Folic acid-functionalized human serum albumin nanocapsules for targeted drug delivery to chronically activated macrophages". International Journal of Pharmaceutics 427 2 (2012): 460-466. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859105871&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2012.02.028
  28. Sampaio, P.; Nogueira, E.; Loureiro, A.S.; Delgado-Silva, Y.; Correia, A.; Pais, C.. "Increased number of glutamine repeats in the C-terminal of Candida albicans Rlm1p enhances the resistance to stress agents". Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology 96 4 (2009): 395-404. http://www.scopus.com/inward/record.url?eid=2-s2.0-72649104600&partnerID=MN8TOARS.
    10.1007/s10482-009-9352-5
Poster em conferência
  1. Loureiro, Ana. "Folic acid-tagged protein nanoemulsions with controllable size for cancer therapy". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  2. Loureiro, Ana. "In vivo toxicity validation of protein nanoemulsions using the ZET assay". Trabalho apresentado em 6th Iberian Meeting on Colloids and Interfaces, RICI6, 2015.
  3. Loureiro, Ana. "Folate-target nanodevices to activated macrophages for rheumatoid arthritis". Trabalho apresentado em 6th Iberian Meeting on Colloids and Interfaces, RICI6, 2015.
  4. Loureiro, Ana. "Preparation and characterization of protein nanospheres prepared by high pressure homogenization". Trabalho apresentado em 8th International Conference on Polymer and Fiber Biotechnology, 2014.
  5. Loureiro, Ana. "Preparation and characterization of protein nanospheres prepared by high pressure homogenization". Trabalho apresentado em Faraday Discussion 166: Self-Assembly of Biopolymers, 2013.
Tese / Dissertação
  1. Loureiro, Ana. "Protein-based nanodevices for therapeutic applications". Doutoramento, Universidade do Minho Escola de Ciências, 2015.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/05/20 Nanopartículas para terapia direcionada Pint of Science Portugal
(Braga, Portugal)
2018/06 Cyclo-oligosaccharides-based nanoemulsions for compound encapsulation 2018 International Conference on Eco Textiles
(Wuxi, China)
2018/05 Albumin-based nanoparticles as drug delivery systems Bionanoparticles: challenges and therapeutic opportunities
(Braga, Portugal)
2017/09 Modification of cyclo-oligosaccharides for drug encapsulation GLUPOR 12 - 12nd International Meeting of the Portuguese Carbohydrate Chemistry Group
(Aveiro, Portugal)
2017/06 Size controlled protein nanoemulsions for active targeting in cancer therapy DESIGNER BIOLOGY: From proteins and cells to scaffolds & materials
(Vienna, Áustria)
2015/06 Albumin-based nanoparticles as drug delivery systems Nanoparticles and the immune system: risks and therapeutic opportunities. 2nd Edition
(Braga, Portugal)
2013/11 Protein based nanoparticles NANOFOL – NanoDiaRA Conference
(Lisboa, Portugal)
2013/06 Production and characterization of BSA nanospheres for drug delivery Nanoparticles and the immune system: risks and therapeutic opportunities
(Braga, Portugal)
2013/04 Production and characterization of BSA nanospheres for drug delivery 245th ACS National Meeting
(New Orleans, Estados Unidos)
2012/03 Preparation and characterization of BSA nanospheres as drug delivery systems 243rd ACS National Meeting
(San Diego, Estados Unidos)
2010/03 Preparation and characterization of protein nanospheres 239th ACS National Meeting
(San Francisco, Estados Unidos)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/09/07 - Atual Development of Topical Formulations for Release of Active Compounds in Rheumatic Diseases
Orientador
Universidade do Minho Centro de Engenharia Biológica, Portugal
2017/09 - 2018/12 Polymeric nanoparticles for Methotrexate delivery
Orientador
Universidade do Minho, Portugal
2017/09 - 2018/12 Development of PEGylated nanoparticles for delivery of methotrexate derivatives
Orientador
Universidade do Minho, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2019/05/20 - 2019/05/20 Invited speaker
Festival
 Pint of Science Festival
Distinções

Prémio

2016 Award for Thesis with Best Publication
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2007 Award for the 3% best students of each course (2004/2005)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal