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Nuno Saraiva. Completed is PhD in Cell Biology and Virology in 2012 by Imperial College London Faculty of Medicine, his MSc in Genetics and Molecular biology in 2008 by Universidade de Lisboa Faculdade de Ciências and his BSc in Micobiology and Genetics in 2006 by Universidade de Lisboa Faculdade de Ciências. Nuno developed his Post-Doc research project at the University of Cambridge, Department of Pathology, UK. He is currently an Assistant Professor in Universidade Lusófona de Humanidades e Tecnologias and a Principal investigator since 2017 at the Research Center for Biosciences & Health Technologies (CBIOS).Has received 2 awards and/or honors. Published more than 20 full articles in high impact international journals and one book chapter. In his professional activities interacted with 216 collaborator(s) co-authorship of scientific papers. Organized various scientific event(s). Supervised 1 PhD thesis(es). Supervised 4 MSc dissertation(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology. In their professional activities interacted with 250 collaborator(s) co-authorship of scientific papers.
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Identificação

Identificação pessoal

Nome completo
Nuno Saraiva

Nomes de citação

  • Saraiva, Nuno

Identificadores de autor

Ciência ID
0A16-91EA-C570
ORCID iD
0000-0003-1333-9137
Google Scholar ID
https://scholar.google.com/citations?user=TVuvhMkAAAAJ&hl=en
Researcher Id
I-9299-2019

Websites

  • http://cbios.ulusofona.pt/ (Profissional)
  • https://scholar.google.com/citations?user=TVuvhMkAAAAJ&hl=en (Académico)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2012
Concluído
 Cell Biology and Virology (Doutoramento)
Imperial College London Faculty of Medicine, Reino Unido
"Biochemical and Functional Characterization of Golgi Anti Apoptotic Proteins (GAAP)" (TESE/DISSERTAÇÃO)
 n/a
2012
Concluído
 Nuno Ricardo de Almeida Saraiva (Doutoramento)
Imperial College London, Reino Unido
"BIOCHEMICAL AND FUCNTIONAL CHARACTERIZATION OF GOLGI ANTI-APOPTOTIC PROTEINS (GAAP)" (TESE/DISSERTAÇÃO)
2008
Concluído
 Genetics and Molecular Biology (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Relation between the structure and function of different APOBEC proteins and their interaction with the HIV-1 Vif protein" (TESE/DISSERTAÇÃO)
 19
2006
Concluído
 Microbiology and Genetics (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

2017 - Atual Investigador principal (carreira) (Investigação)
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2014 - 2017 Investigador (Investigação)
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal

Docência no Ensino Superior

2013/01/01 - Atual Professor Auxiliar (Docente Universitário)
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2011/03/01 - 2011/05/01 Assistente Convidado (Docente Universitário)
University of Cambridge Department of Pathology, Reino Unido
2009/11/01 - 2010/02/01 Assistente Convidado (Docente Universitário)
Imperial College London Department of Investigative Medicine, Reino Unido

Outros

2018/01/27 - 2018/02/11 Invited Scientist
Medizinische Universität Wien Institut für Medizinische Chemie, Áustria
2018/01/07 - 2018/01/12 Invited Scientist
King's College London - Guy's Campus, Reino Unido
2015/01/31 - 2015/02/22 Invited Scientist
University of Cambridge Department of Pathology, Reino Unido
2012/03/02 - 2012/09/21 Post-doc at Prof. Geoffrey Smith laboratory
University of Cambridge Department of Pathology, Reino Unido
2007/12/01 - 2008/09/30 Research assistant at Prof. João Gonçalves Laboratory.
Universidade de Lisboa Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2021 - 2023/08/31 Lusophone flora fighting disease: focus on therapeutic lysyl oxidase modulators
ILIND/F+/EI/01/2020
Investigador
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
 Instituto Lusófono de Investigação e Desenvolvimento
2021 - 2022 Abietane Cationic Amphiphiles (ACA) to tackle resistant bacteria
COFAC/ILIND/CBIOS/1/2020
Investigador
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
 Instituto Lusófono de Investigação e Desenvolvimento
2020 - 2020/12 Redox modulation of cancer progression
FIPID - COFAC Grant Programme 2019/2020
Investigador
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
 Instituto Lusófono de Investigação e Desenvolvimento
2018 - 2018/02 Combinatory effects of food xenoestrogen mycotoxins with the soy isoflavone genistein in breast cancer cell: redox status and migration.
COST-STSM-CA16112-39323
 European Cooperation in Science and Technology
2018 - 2018/01 Impact of hGAAP on cell invasion: role of mitochondrial Ca2+
COST-STSM-CA15214-39037
 European Cooperation in Science and Technology
2015 - 2015/03 ROS impact on cell migration and adhesion (SOD mimics)
COST-STSM-BM1203-24673
 European Cooperation in Science and Technology
2009 - 2014/04 Human and viral Golgi anti-apoptotic protein (GAAP); a structural and functional study of its mechanism of action
G0900224
 Medical Research Council
2008 - 2012/02 A study of the human and viral Golgi-anti-apoptotic protein
PhD : SFRH/BD/40714/2007
 Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2007 - 2011/02 Genome-wide screening with libraries of synthetic zinc-finger proteins capable to modulate host gene expression: Application in HIV-1 infection.
Provided by PTCRIS: 71599
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Sandra Ferreira; Nuno Saraiva; Patrícia Rijo; Ana S. Fernandes. "LOXL2 Inhibitors and Breast Cancer Progression". Antioxidants 10 2 (2021): 312-312. https://doi.org/10.3390/antiox10020312.
    10.3390/antiox10020312
  2. Sofia Ramos; Ana Sofia Fernandes; Nuno Saraiva. "Gene expression and survival analysis in cancer research using online open access platforms: a comparative analysis". Biomedical and Biopharmaceutical Research Journal (2020): https://doi.org/10.19277/bbr.17.2.247.
    10.19277/bbr.17.2.247
  3. Rita Manguinhas; Ana S. Fernandes; João G. Costa; Nuno Saraiva; Sérgio P. Camões; Nuno Gil; Rafael Rosell; et al. "Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion". Antioxidants 9 6 (2020): 550-550. https://doi.org/10.3390/antiox9060550.
    10.3390/antiox9060550
  4. Nuno Saraiva; João G. Costa; Catarina Reis; Nuno Almeida; Patrícia Rijo; Ana Sofia Fernandes; Saraiva, Nuno; et al. "Anti-Migratory and Pro-Apoptotic Properties of Parvifloron D on Triple-Negative Breast Cancer Cells". Biomolecules (2020): https://doi.org/10.3390/biom10010158.
    10.3390/biom10010158
  5. Almeida, Nuno; Carrara, Guia; Palmeira, Carlos M.; Fernandes, Ana S.; Parsons, Maddy; Smith, Geoffrey L.; Saraiva, Nuno. "Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism". Redox Biology 28 (2020): 101361. http://dx.doi.org/10.1016/j.redox.2019.101361.
    10.1016/j.redox.2019.101361
  6. Costa, J. G.; Keser, V.; Jackson, C.; Saraiva, N.; Guerreiro, I.; Almeida, N.; Camoes, S. P.; et al. "A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells". Food and Chemical Toxicology (2020): https://publons.com/publon/28478936/.
    10.1016/J.FCT.2019.111076
  7. Gabriel Satoto; Ana Sofia Fernandes; Nuno Saraiva; Fernando Santos; Nuno Neng; José Manuel Nogueira; Tânia Santos de Almeida; et al. "An Overview on the Properties of Ximenia Oil Used as Cosmetic in Angola". Biomolecules 10 1 (2019): 18-18. https://doi.org/10.3390/biom10010018.
    10.3390/biom10010018
  8. João G. Costa; Nuno Saraiva; Ines Batinic-Haberle; Matilde Castro; Nuno G. Oliveira; Ana S. Fernandes; Costa, Joao G.; et al. "The SOD Mimic MnTnHex-2-PyP5+ Reduces the Viability and Migration of 786-O Human Renal Cancer Cells". Antioxidants (2019): https://doi.org/10.3390/antiox8100490.
    10.3390/antiox8100490
  9. João Guilherme Costa; Bojana Vidovic; Nuno Saraiva; Maria do Céu Costa; Giorgia Del Favero; Doris Marko; Nuno G. Oliveira; Ana Sofia Fernandes. "Contaminants: a dark side of food supplements?". Free Radical Research (2019): https://doi.org/10.1080/10715762.2019.1636045.
    10.1080/10715762.2019.1636045
  10. Marisa Nicolai; Nuno Almeida; Patricia Rijo; João Guilherme Costa; Nuno Saraiva; Ana Sofia Fernandes. "Cytotoxic effect of antioxidants found in food from plant origin on human osteosarcoma U2OS Cells". Journal Biomedical and Biopharmaceutical Research (2019): https://doi.org/10.19277/BBR.16.1.202.
    10.19277/BBR.16.1.202
  11. Diogo Matias; Marisa Nicolai; Ana Sofia Fernandes; Nuno Saraiva; Joana Almeida; Lucília Saraiva; Célia Faustino; et al. "Comparison Study of Different Extracts of Plectranthus madagascariensis, P. neochilus and the Rare P. porcatus (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities". Biomolecules 9 5 (2019): 179-179. https://doi.org/10.3390/biom9050179.
    10.3390/biom9050179
  12. Sierla M; Prole DL; Saraiva, Nuno; Carrara, Guia; Dinischiotu N; Wrzaczek M; Taylor CW; et al. "Golgi anti-apoptotic proteins are evolutionarily conserved ion channels that regulate cell death in plants". ioRxiv 859678 (2019): https://www.biorxiv.org/content/10.1101/859678v1.
    10.1101/859678
  13. Keser, V.; Costa, J. G.; Jackson, C.; Saraiva, N.; Almeida, N.; Camoes, S. P.; Castro, M.; et al. "Migration and invasion of human renal cancer cells are impaired upon treatment with thymoquinone". Toxicology Letters (2019): https://publons.com/publon/27015535/.
  14. Florido, Ana; Saraiva, Nuno; Cerqueira, Sara; Almeida, Nuno; Parsons, Maddy; Batinic-Haberle, Ines; Miranda, Joana P.; et al. "The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells". Redox Biology (2019): https://publons.com/publon/14703536/.
    10.1016/J.REDOX.2018.10.016
  15. Egea, J.; Fabregat, I.; Frapart, Y. M.; Ghezzi, P.; Goerlach, A.; Kietzmann, T.; Kubaichuk, K.; et al. "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) (vol 13, pg 94, 2017)". Redox Biology 13 (2018): 94-162. https://publons.com/publon/1453692/.
    10.1016/J.REDOX.2017.10.001
  16. Almeida, Nuno; Carrara, Guia; Fernandes, Ana; Parsons, Maddy; Smith, Geoffrey; Saraiva, Nuno. "The human Golgi anti-apoptotic protein induces cell invasion by an H2O2-dependent mechanism". Free Radical Biology and Medicine (2018): https://publons.com/publon/31299260/.
    10.1016/J.FREERADBIOMED.2018.04.107
  17. Costa, Joao; Saraiva, Nuno; Rijo, Patricia; Almeida, Nuno; Reis, Catarina; Fernandes, Ana Sofia. "Anti-tumor properties of the redox-active compound Parvifloron D in breast cancer cells". Free Radical Biology and Medicine (2018): https://publons.com/publon/9451208/.
    10.1016/J.FREERADBIOMED.2018.04.394
  18. Saraiva, Nuno; Floridol, Ana; Costa, Joao; Parsons, Maddy; Batinic-Haberle, Ines; Miranda, Joana Paiva; Castro, Matilde; Oliveira, Nuno Guerreiro; Fernandes, Ana Sofia. "Beneficial impact of a manganese(III) porphyrin in cancer cell migration". Free Radical Biology and Medicine (2018): https://publons.com/publon/9451209/.
    10.1016/J.FREERADBIOMED.2018.04.387
  19. Nuno Almeida; Lara Ribeiro; João G. Costa; Patricia Rijo; M. Eduarda Araújo; Nuno Saraiva; Ana Sofia Fernandes. "Cytotoxicity of N-nitrosoguanidines in a breast cancer cell model". Journal Biomedical and Biopharmaceutical Research (2017): https://doi.org/10.19277/BBR.14.2.159.
    10.19277/BBR.14.2.159
  20. Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al. "Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]". Redox Biology (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85032289195&partnerID=MN8TOARS.
    10.1016/j.redox.2017.10.001
  21. Santos de Almeida, T.; Júlio, A.; Saraiva, N.; Fernandes, A.S.; Araújo, M.E.M.; Baby, A.R.; Rosado, C.; Mota, J.P.. "Choline- versus imidazole-based ionic liquids as functional ingredients in topical delivery systems: cytotoxicity, solubility, and skin permeation studies". Drug Development and Industrial Pharmacy 43 11 (2017): 1858-1865. http://www.scopus.com/inward/record.url?eid=2-s2.0-85023747624&partnerID=MN8TOARS.
    10.1080/03639045.2017.1349788
  22. Guerreiro, P.S.; Corvacho, E.; Costa, J.G.; Saraiva, N.; Fernandes, A.S.; Castro, M.; Miranda, J.P.; et al. "The APE1 redox inhibitor E3330 reduces collective cell migration of human breast cancer cells and decreases chemoinvasion and colony formation when combined with docetaxel". Chemical Biology and Drug Design 90 4 (2017): 561-571. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018948782&partnerID=MN8TOARS.
    10.1111/cbdd.12979
  23. Carrara, G.; Parsons, M.; Saraiva, N.; Smith, G.L.; Guia Carrara; Maddy Parsons; Nuno Saraiva; Geoffrey L. Smith. "Golgi anti-apoptotic protein: A tale of camels, calcium, channels and cancer". Open Biology 7 5 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020011420&partnerID=MN8TOARS.
    10.1098/rsob.170045
  24. Costa, Joao G.; Saraiva, Nuno; Guerreiro, Patricia S.; Castro, Matilde; Batinic-Haberle, Ines; Oliveira, Nuno G.; Fernandes, Ana S.. "Viability and migration of human renal cancer cells upon treatment with a superoxide dismutase mimic". Toxicology Letters (2017): https://publons.com/publon/28478938/.
    10.1016/J.TOXLET.2017.07.312
  25. Francisco Caldeira; João Costa; Patricia Rijo; Nuno Saraiva; Ana Fernandes; Ana S. Fernandes. "Xanthine Oxidase Inhibitory Activity of a Plectranthus saccatus aqueous extract". Journal Biomedical and Biopharmaceutical Research (2016): https://doi.org/10.19277/bbr.13.2.143.
    10.19277/bbr.13.2.143
  26. Costa, Joao G.; Saraiva, Nuno; Guerreiro, Patricia S.; Louro, Henriqueta; Silva, Maria J.; Miranda, Joana P.; Castro, Matilde; et al. "Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints". Food and Chemical Toxicology 87 (2016): 65-76. https://publons.com/publon/2063150/.
    10.1016/J.FCT.2015.11.018
  27. Oliveira Silva, Catarina; Molpeceres, Jesus; Batanero, Belen; Fernandes, Ana Sofia; Saraiva, Nuno; Costa, Joao Guilherme; Rijo, Patricia; et al. "Functionalized diterpene parvifloron D-loaded hybrid nanoparticles for targeted delivery in melanoma therapy". Therapeutic Delivery 7 8 (2016): 521-544. https://publons.com/publon/960725/.
    10.4155/TDE-2016-0027
  28. Fernandes, Ana S.; Saraiva, Nuno; Oliveira, Nuno G.. "Redox Therapeutics in Breast Cancer: Role of SOD Mimics". Studies on Retinal and Choroidal Disorders (2016): https://publons.com/publon/19648025/.
    10.1007/978-3-319-30705-3_18
  29. Carrara, G.; Saraiva, N.; Parsons, M.; Byrne, B.; Prole, D.L.; Taylor, C.W.; Smith, G.L.. "Golgi anti-apoptotic proteins are highly conserved ion channels that affect apoptosis and cell migration". Journal of Biological Chemistry 290 18 (2015): 11785-11801. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928808798&partnerID=MN8TOARS.
    10.1074/jbc.M115.637306
  30. de Almeida, T. Santos; Julio, A.; Caparica, R.; Rosado, C.; Fernandes, A. S.; Saraiva, N.; Ribeiro, M.; et al. "Ionic liquids as solubility/permeation enhancers for topical formulations: Skin permeation and cytotoxicity characterization". Toxicology Letters (2015): https://publons.com/publon/9451210/.
    10.1016/J.TOXLET.2015.08.841
  31. Guia Carrara; Nuno Saraiva; Maddy Parsons; Bernadette Byrne; David L. Prole; Colin W. Taylor; Geoffrey L. Smith. "Golgi Anti-apoptotic Proteins Are Highly Conserved Ion Channels That Affect Apoptosis and Cell Migration". Journal of Biological Chemistry (2015): https://publons.com/publon/2063151/.
    10.1074/JBC.M115.637306
  32. Florido, A.; Saraiva, N.; Cerqueira, S.; Batinic-Haberle, I.; Proenca, S.; Miranda, J.; Castro, M.; Oliveira, N. G.; Fernandes, A. S.. "Impact of the SOD mimic MnTnHex-2-PyP on the adhesion and migration of doxorubicin-treated MDA-MB-231 cells". Toxicology Letters (2015): https://publons.com/publon/11842789/.
    10.1016/J.TOXLET.2015.08.711
  33. Ana S. Fernandes; Ana Flórido; Nuno Saraiva; Sara Cerqueira; Sérgio Ramalhete; Madalena Cipriano; Maria Fátima Cabral; et al. "Role of the Copper(II) Complex Cu[15]pyN 5 in Intracellular ROS and Breast Cancer Cell Motility and Invasion". Chemical Biology & Drug Design 86 4 (2015): 578-588. https://publons.com/publon/2063152/.
    10.1111/CBDD.12521
  34. Matias, D.; Nicolai, M.; Costa, J.; Saraiva, N.; Fernandes, A. S.; Simoes, M. F.; Diaz-Lanza, A. M.; Reis, C. P.; Rijo, P.. "Cytotoxicity screening of Plectranthus spp. extracts and individual components in MDA-MB-231 cells". Toxicology Letters (2015): https://publons.com/publon/960734/.
    10.1016/J.TOXLET.2015.08.707
  35. Costa, J.; Saraiva, N.; Guerreiro, P.; Miranda, J. P.; Batinic-Haberle, I.; Castro, M.; Oliveira, N. G.; Fernandes, A. S.. "Effect of the SOD mimetic MnTnHex-2-PyP on the generation of ROS and cytotoxicity induced by ochratoxin A". Toxicology Letters (2015): https://publons.com/publon/5063376/.
    10.1016/J.TOXLET.2015.08.840
  36. Fernandes, Ana S.; Florido, Ana; Saraiva, Nuno; Cerqueira, Sara; Cipriano, Madalena; Cabral, M. Fatima; Miranda, Joana P.; et al. "Effect of Cu[15]pyN(5) on MDA-MB-231 cell migration and invasion". Toxicology Letters (2014): https://publons.com/publon/5063324/.
    10.1016/J.TOXLET.2014.06.531
  37. Matias, D.; Pereira, F.; Nicolai, M.; Roberto, A.; Saraiva, N.; Fernandes, A. S.; Simoes, M. F.; et al. "Abietane diterpenes from Plectranthus madagascariensis: A cytotoxicity screening". Planta Medica (2014): https://publons.com/publon/960743/.
    10.1055/S-0034-1394809
  38. Nelson Tavares; Maria Lidia Laginha Mestre Guerreiro Palma; Catarina Silva; Aura Silva; Elisabete Mauricio; Nuno Saraiva; André Baby. "CBiOS Science Sessions - 2013". Journal Biomedical and Biopharmaceutical Research (2013): https://doi.org/10.19277/BBR.10.2.70.
    10.19277/BBR.10.2.70
  39. Saraiva, N.; Prole, D.L.; Carrara, G.; Johnson, B.F.; Taylor, C.W.; Parsons, M.; Smith, G.L.. "HGAAP promotes cell adhesion and migration via the stimulation of store-operated ca2+ entry and calpain 2". Journal of Cell Biology 202 4 (2013): 699-713. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884275701&partnerID=MN8TOARS.
    10.1083/jcb.201301016
  40. Saraiva, N.; Prole, D.L.; Carrara, G.; De Motes, C.M.; Johnson, B.F.; Byrne, B.; Taylor, C.W.; et al. "Human and viral golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium". Journal of Biological Chemistry 288 18 (2013): 13057-13067. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877153243&partnerID=MN8TOARS.
    10.1074/jbc.M112.414367
  41. Fernandes, A. S.; Florido, A.; Cipriano, M.; Batinic-Haberle, I.; Miranda, J.; Saraiva, N.; Guerreiro, P. S.; Castro, M.; Oliveira, N. G.. "Combined effect of the SOD mimic MnTnHex-2-PyP5+ and doxorubicin on the migration and invasiveness of breast cancer cells". Toxicology Letters (2013): https://publons.com/publon/2169298/.
    10.1016/J.TOXLET.2013.05.052
  42. Nuno Saraiva; David L. Prole; Guia Carrara; Benjamin F. Johnson; Colin W. Taylor; Maddy Parsons; Geoffrey L. Smith. "hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca 2+ entry and calpain 2". The Journal of Cell Biology (2013): https://publons.com/publon/2063154/.
    10.1083/JCB.201301016
  43. Carrara, G.; Saraivas, N.; Gubsers, C.; Johnson, B.F.; Smith, G.L.. "Six-transmembrane topology for golgi anti-apoptotic protein (GAAP) and bax inhibitor 1 (BI-1) provides model for the transmembrane bax inhibitor-containing motif (TMBIM) family". Journal of Biological Chemistry 287 19 (2012): 15896-15905. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860868195&partnerID=MN8TOARS.
    10.1074/jbc.M111.336149
  44. Guia Carrara; Nuno Saraiva; Caroline Gubser; Benjamin F. Johnson; Geoffrey L. Smith. "Six-transmembrane Topology for Golgi Anti-apoptotic Protein (GAAP) and Bax Inhibitor 1 (BI-1) Provides Model for the Transmembrane Bax Inhibitor-containing Motif (TMBIM) Family". Journal of Biological Chemistry (2012): https://publons.com/publon/2063156/.
    10.1074/JBC.M111.336149
  45. Cadima-Couto, I.; Saraiva, N.; Santos, A.C.C.; Goncalves, J.. "HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay". Journal of Neuroimmune Pharmacology 6 2 (2011): 296-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957449842&partnerID=MN8TOARS.
    10.1007/s11481-011-9258-7
  46. Cadima-Couto, Iris; Saraiva, Nuno; Santos, Ana Catarina C.; Goncalves, Joao. "HIV-1 Vif Interaction with APOBEC3 Deaminases and its Characterization by a New Sensitive Assay". Journal of NeuroImmune Pharmacology (2011): https://publons.com/publon/2063157/.
    10.1007/S11481-011-9258-7
Tese / Dissertação
  1. Saraiva, Nuno Ricardo de Almeida. "Relação estrutura/função das proteínas da família APOBEC e sua interacção com a proteína Vif do HIV-1". Mestrado, 2007. http://hdl.handle.net/10451/1194.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/10/11 Overexpression of the Golgi protein hGAAP Increases Cell Survival upon Prolonged Time in Culture. Physioma - 1st International Meeting of the Portuguese Society of Physiology. 10-11 October 2019, Lisbon. Physioma - 1st International Meeting of the Portuguese Society of Physiology
Portuguese Society of Physiology (Lisbon, Portugal)
2019/05/16 The human Golgi ion channel GAAP induces cell invasion by promoting proteolytic degradation of ECM: role of H2O2 and metabolism. Annual meeting of the French society for extracellular matrix biology
(Reims, França)
2019/04/01 The role of a new family of Golgi ion channels on cell invasion Mechanobiology of migrating Cells: From Basic Science to the Clinic
(Coimbra, Portugal)
2019/04/01 Modulation of cancer cell migration by redox-active compounds Mechanobiology of migrating Cells: From Basic Science to the Clinic
(Coimbra, Portugal)
2018/11 Reactive oxygen species on cancer cell migration and invasion. EuroCellNet workgroup meeting - Mechanobiology of cells and tissues in health and disease.
EuroCellNet (Eslovénia)
2018/09/01 The role of ROS in cancer cell invasion. EuroCellNet workgroup meeting WG3
(Prague, República Checa)
2018/06/01 Human anti-apoptotic protein induces cell invasion by an H2O2-dependent mechanism. 19th SFRRI Biennial Meeting
(Portugal)
2018/05 Human anti-apoptotic protein induces cell invasion by an H2O2-dependent mechanism. An integrative action for multidisciplinary studies on cellular structural networks (EuroCellNet COST action) MC meeting
COST association (Brussels, Bélgica)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019/01/01 - Atual Expression profile of cellular redox and calcium signalling-related genes: role in breast cancer progression
Orientador
 Heath Sciences PhD course (Doutoramento)
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2019 - Atual Impact of the human Golgi anti-apoptotic protein (hGAAP) in Glioblastoma progression
Orientador
 Oncobiology (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2019 Role of Ca2+ on the cellular mechanisms involved in metastasis formation
Orientador
 Pharmaceutical Sceinces (Mestrado)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2014/01/01 - 2015 The impact of super oxide dismutase mimics on breast cancer cell adhesion and migration.
Orientador de Sara Cerqueira
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/04/01 - Atual Mechanobiology of migrating Cells: From Basic Science to the Clinic. (2019/04/01)
Conferência (Membro da Comissão Científica)
 European Cooperation in Science and Technology, Bélgica

Universidade de Coimbra, Portugal
2018/11 - Atual Member of the scientific committee for the International Ljubljana EuroCellNet meeting (COST action meeting) entitled Mechanobiology of cells and tissues in health and disease. (2018/11)
Conferência (Membro da Comissão Científica)
2014 - Atual 1as, 2as, 3as, 4as Jornadas CBIOS (desde 2014) (2014)
Conferência (Membro da Comissão Organizadora)
 Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2019/10/01 - 2019/10/01 Member of the organization committee of the International Lisbon NutRedOx meeting (COST action meeting) entitled “Nutrition and Aging”. (2019/10/01 - 2019/10/01)
Conferência
 Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2019 - 2019 International Lisbon NutRedOx meeting (COST action meeting) entitled “Nutrition and Aging”. (2019)
Conferência (Membro da Comissão Organizadora)
 Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal

European Cooperation in Science and Technology, Bélgica
2016/01/01 - 2016/01/01 Member of the Lisbon EU-ROS COST action (BM1203) meeting organizing committee. (2016)
Congresso
 European Cooperation in Science and Technology, Bélgica

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2020 - Atual Invited speaker at the two “COVID-19: present and future therapeutic approaches” debates organized by APEF for Pharmaceutical Sciences students.
Mesa-redonda
 “COVID-19: present and future therapeutic approaches”
2018/11/01 - Atual Invited speaker (round table discussion) at the oncology panel of the Drug Discovery and Development meeting.
Mesa-redonda
 Drug Discovery and Development meeting.
Universidade de Lisboa Faculdade de Farmácia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2018/11/08 - 2018/11/09 Mechanobiology of cells and tissues in health and disease (EuroCellNet COST action meeting) Medical Center for Molecular Biology, Faculty of Medicine, University of Ljubljana
2016/03 - 2016/03 International Lisbon EU-ROS meeting (COST action meeting) Universidade Lusófona, CBIOS, Lisbon, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019/10/10 - Atual Coordinator and lecturer of the “Cell migration: concepts, mechanisms and techniques” workshop in collaboration with the NutRedOx COST action training school. Cell migration (Especialização pós-licenciatura) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2016/01/01 - Atual Coordinator and le lecturer at the course "Manipulação e Análise de Expressão Génica" Manipulação e Análise de Expressão Génica (Especialização pós-licenciatura) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2014/09/01 - Atual Cell Biology (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2014/09/01 - Atual Molecular Biology (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias Centro de Investigação em Biociências e Tecnologias da Saúde, Portugal
2014 - Atual Lecturing on the Cell Culture post-graduation course at ECTS, Lusófona University, Lisbon (Especialização pós-licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2019 - 2019 Invited lecturer at the Frontiers in Biology Research module. Lecture entitled: "The role of Ca2+ and ROS signalling in (cancer) cell survival and motility." Molecular and Genetics MSc (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2018 - 2018 “Cell migration workshop” lecturer and coordinator at IBILI Cell Biology Universidade de Coimbra, Portugal
2016 - 2018 “Gene expression manipulation and analysis” post-graduation course coordinator “Gene expression manipulation and analysis” (Especialização pós-licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2011/03/01 - 2011/05/01 Teaching on the Laboratory Practicals of the Virology module form the Biology of the Disease course. University of Cambridge Department of Pathology, Reino Unido
2011 - 2011 Teaching on the Laboratory Practical classes of the Virology module form the Biology of Disease course Virology University of Cambridge Department of Pathology, Reino Unido
2009/11/01 - 2010/02/01 Teaching on the Laboratory Practicals of the “MSc in the molecular biology and pathology of virus” course. Imperial College Faculty of Medicine - Saint Mary's Campus, Reino Unido
2009 - 2010 Teaching laboratory practical classes on the “MSc in the molecular biology and pathology of virus” course Virology Imperial College London, Reino Unido

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2020/08 Collaboration with Polígrafo/SIC (online fact checking journalistic project) on COVID-19. This project aims at fighting misinformation generated and propagated in social networks. This interview was about SARS-CoV2 viral load. Polígrafo/SIC
2020/07 Collaboration with Polígrafo/SIC (online fact checking journalistic project) on COVID-19. This project aims at fighting misinformation generated and propagated in social networks. This interview was about chlorine dioxide. Polígrafo/SIC

Entrevista / Programa (rádio / tv)

Programa Tema
2020/09/17 - Atual Explicador (Rádio Observador) Aumento de casos de covid-19, a alteração do perfil etário dos infectados e o impacto do regresso às aulas.

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2020/01/01 - Atual Member (management committee) of the “ADHEsion GPCR Network: Research and Implementation Set the path for future Exploration” COST action (CA18240).
Membro
 European Cooperation in Science and Technology, Bélgica
2019 - Atual Member (management committee) of the “European Research Network on Signal Transduction” COST action (CA18133)
Membro
 European Cooperation in Science and Technology, Bélgica
2016 - Atual Member (management committee) of the COST ACTION (CA 15214) An Integrative Action for Multidisciplinary Studies on Cellular Structural Networks.
Membro
 European Cooperation in Science and Technology, Bélgica
2016 - Atual Research Center for Biosciences & Health Technologies (CBIOS) Scientific Committee member Universidade Lusófona de Humanidades e Tecnologias, Portugal
2016 - Atual Research Center for Biosciences & Health Technologies (CBIOS) Scientific Committee member Scientific Committee member
Membro
 Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2019/06 - Atual Member of the research grant jury within the scope of the Research Center in Biosciences and Health Technologies (CBIOS) with the reference UID / DTP / 04567/2019 - BI2, as effective member Universidade Lusófona de Humanidades e Tecnologias, Portugal
2018/06 - Atual Member of the BI - CBIOS / PRUID / BI3 / 2018 research scholarship jury, within the scope of the Biosciences and Health Technologies Research Center (CBIOS) with the reference UID / DTP / 04567/2016, as effective member Universidade Lusófona de Humanidades e Tecnologias, Portugal
Distinções

Prémio

2020 Best poster at the ASPIC «Cancer Biology: From Basic To Translational Research» meeting.
Liga Portuguesa Contra o Cancro, Portugal
2019 Best oral presentation at the Physioma2019 Meeting
Portuguese Physiology Society, Portugal
2014 Award for best poster at the 2014 Iberian Toxicology Meeting at Covilhã, Portugal.
2011 Award for best poster at the 2011 The Biochemical Society Annual Symposium on Recent advances in Membrane biochemistry, Cambridge.
Biochemical Society, Reino Unido