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Christa Rhiner received her Master degree in 2012 following a Master thesis (immunology and prion disease) in the lab of Prof. Adriano Aguzzi at the University Hospital in Zurich. She then entered the International Neuroscience PhD program of the ETH/University of Zurich and joined the lab of Prof. Michael O. Hengartner to work on axon guidance signalling. Apart from her PhD, she also obtained a degree in science communication from the Institute for Applied Media Studies. For her postdoctoral studies (2006-2010), she moved to the group of Dr. Eduardo Moreno at the National Cancer Center (CNIO) in Madrid and investigated novel factors mediating cell competition in Drosophila and mice. In 2011, Christa joined the Institute of Cell Biology in Bern as lecturer and investigator where she worked on neuronal fitness and established Drosophila as a model to study brain regenerative processes. In 2017, she started her own group at the Champalimaud Center in Lisbon focusing on neural stem cell control, adult brain plasticity and brain-body communication. Christa Rhiner has authored 24 publications (h-index 19) and as group leader has received several grants including an FCT ERC Protugal grant and a LaCaixa-FCT Health grant. Christa has supervised 2 PhD thesis (+ 1 ongoing) and co-supervised 1 PhD student (+ 1 ongoing), 2 postdocs (+ 4 ongoing) and 4 Master and 1 Bachelor students. Members of the Rhiner lab have successfully obtained competitive grants such as postdoc fellowships from HSFP and Lundbeck Foundation and FCT PhD fellowships.
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Identificação

Identificação pessoal

Nome completo
Christa Rhiner

Identificadores de autor

Ciência ID
0413-6C50-3FD4
ORCID iD
0000-0001-7577-8042

Endereços de correio eletrónico

  • christa.rhiner@research.fchampalimaud.org (Profissional)

Websites

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Alemão (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1)
Português Utilizador independente (B2) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Italiano Utilizador independente (B1) Utilizador independente (B2) Utilizador elementar (A2) Utilizador independente (B2)
Formação
Grau Classificação
2020/11 - 2020/11
Frequentou
 EMBO laboratory leadership course (Postgraduate Certificate)
Heidelberger Akademie der Wissenschaften, Alemanha
2006
Concluído
 International Neuroscience PhD program ETH/University of Zurich (Doktor (PhD))
Universität Zürich Institut für Molekulare Biologie, Suiça
"Heparan Sulfate Proteoglycans in Nervous System Development of C. elegans" (TESE/DISSERTAÇÃO)
 PhD
2004
Concluído
 Science communication (Postgraduate Certificate)
Zürcher Hochschule für Angewandte Wissenschaften Hochschulbibliothek Winterthur, Suiça
"n/a" (TESE/DISSERTAÇÃO)
 n/a
2002
Concluído
 integrated Master in Cell Biology (Mestrado)
Universität Bern Institut für Zellbiologie, Suiça
"Immunologic Strategies against Prion Diseases, University Hospital of Zurich" (TESE/DISSERTAÇÃO)
 6/6
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/12 - Atual Investigador principal (carreira) (Investigação) Programa Champalimaud de Neurociências, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/09/01 - 2016/07/15 Lecturer and Investigator Universität Bern, Suiça
2006/12/01 - 2010/09/01 Postdoctoral fellow, identification and characterization of novel cell competition genes in Drosophila and mammals Centro Nacional de Investigaciones Oncológicas, Espanha
2002/09/01 - 2006/09/01 Graduate student, International Neuroscience PhD program, ETH and University of Zurich. Universität Zürich, Suiça
Projetos

Bolsa

Designação Financiadores
2023/12 - 2027/04 Unravelling pro-regenerative signaling modules in the injured brain (BrainImpact)
HR23-00860
Investigador responsável
Fundação Champalimaud, Portugal
 Fundação para a Ciência e a Tecnologia

Fundação 'la Caixa'
2024/02/07 - 2027/02/07 Unravelling local and systemic communication promoting brain repair and homeostasis (BrainSySTEMic)
ERC-Portual Christa Rhiner
Investigador responsável
Fundação Champalimaud, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 Molecular Mechanisms of Neural Stem Cell Activation following Brain Injury in Drosophila
FCT-PTDC/BIA-MOL/31170/2017
Investigador responsável
Centro Champalimaud, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Rhiner, Christa; Suzanne, Magali; Liu, Guang-Hui; Tait, Stephen W.G.; Torii, Keiko U.; Ichikawa, Takafumi; Zhang, Hui Ting; Liu, Wen-Cheng; Sun, Ning. "Voicing the story behind the cover". Developmental Cell 57 24 (2022): 2679-2682. http://dx.doi.org/10.1016/j.devcel.2022.11.019.
    10.1016/j.devcel.2022.11.019
  2. Simões, Anabel R.; Neto, Marta; Alves, Carolina S.; Santos, Mariana B.; Fernández-Hernández, Ismael; Veiga-Fernandes, Henrique; Brea, David; et al. "Damage-responsive neuro-glial clusters coordinate the recruitment of dormant neural stem cells in Drosophila". Developmental Cell 57 13 (2022): 1661-1675.e7. http://dx.doi.org/10.1016/j.devcel.2022.05.015.
    10.1016/j.devcel.2022.05.015
  3. Sanchez Bosch, Pablo; Makhijani, Kalpana; Herboso, Leire; Gold, Katrina S.; Baginsky, Rowan; Woodcock, Katie J.; Alexander, Brandy; et al. "Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues". Developmental Cell 51 6 (2019): 787-803.e5. https://doi.org/10.1016/j.devcel.2019.10.017.
    10.1016/j.devcel.2019.10.017
  4. Madan, Esha; Pelham, Christopher J.; Nagane, Masaki; Parker, Taylor M.; Canas-Marques, Rita; Fazio, Kimberly; Shaik, Kranti; et al. "Flower isoforms promote competitive growth in cancer". Nature 572 7768 (2019): 260-264. http://dx.doi.org/10.1038/s41586-019-1429-3.
    10.1038/s41586-019-1429-3
  5. Coelho, Dina S.; Schwartz, Silvia; Merino, Marisa M.; Hauert, Barbara; Topfel, Barbara; Tieche, Colin; Rhiner, Christa; Moreno, Eduardo. "Culling Less Fit Neurons Protects against Amyloid-ß-Induced Brain Damage and Cognitive and Motor Decline". Cell Reports 25 13 (2018): 3661-3673.e3. http://dx.doi.org/10.1016/j.celrep.2018.11.098.
    10.1016/j.celrep.2018.11.098
  6. Schwartz, Silvia; Rhiner, Christa. "Reservoirs for repair? Damage-responsive stem cells and adult tissue regeneration in Drosophila". The International Journal of Developmental Biology 62 6-7-8 (2018): 465-471. http://dx.doi.org/10.1387/ijdb.180056cr.
    10.1387/ijdb.180056cr
  7. Simões, Anabel R.; Rhiner, Christa. "A Cold-Blooded View on Adult Neurogenesis". Frontiers in Neuroscience 11 (2017): http://dx.doi.org/10.3389/fnins.2017.00327.
    10.3389/fnins.2017.00327
  8. Fernández-Hernández, Ismael; Rhiner, Christa. "New neurons for injured brains? The emergence of new genetic model organisms to study brain regeneration". Neuroscience & Biobehavioral Reviews 56 (2015): 62-72. http://dx.doi.org/10.1016/j.neubiorev.2015.06.021.
    10.1016/j.neubiorev.2015.06.021
  9. Moreno, Eduardo; Fernandez-Marrero, Yuniel; Meyer, Patricia; Rhiner, Christa. "Brain Regeneration in Drosophila Involves Comparison of Neuronal Fitness". Current Biology 25 7 (2015): 955-963. http://dx.doi.org/10.1016/j.cub.2015.02.014.
    10.1016/j.cub.2015.02.014
  10. Merino, Marisa M.; Rhiner, Christa; Lopez-Gay, Jesus M.; Buechel, David; Hauert, Barbara; Moreno, Eduardo. "Elimination of Unfit Cells Maintains Tissue Health and Prolongs Lifespan". Cell 160 3 (2015): 461-476. http://dx.doi.org/10.1016/j.cell.2014.12.017.
    10.1016/j.cell.2014.12.017
  11. Moreno, Eduardo; Rhiner, Christa. "Darwin's multicellularity: from neurotrophic theories and cell competition to fitness fingerprints". (2014):
    10.1016/j.ceb.2014.06.011
  12. Gysi, S.; Rhiner, C.; Flibotte, S.; Moerman, D.G.; Hengartne, M.O.. "Correction: A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans (PLoS ONE)". PLoS ONE 9 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84898441612&partnerID=MN8TOARS.
    10.1371/annotation/439d7826-5008-437d-9b41-5afb31c704a1
  13. Fernández-Hernández, Ismael; Rhiner, Christa; Moreno, Eduardo. "Adult Neurogenesis in Drosophila". Cell Reports 3 6 (2013): 1857-1865. http://dx.doi.org/10.1016/j.celrep.2013.05.034.
    10.1016/j.celrep.2013.05.034
  14. Gysi, S.; Rhiner, C.; Flibotte, S.; Moerman, D.G.; Hengartner, M.O.. "A Network of HSPG Core Proteins and HS Modifying Enzymes Regulates Netrin-Dependent Guidance of D-Type Motor Neurons in Caenorhabditis elegans". PLoS ONE 8 9 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884185123&partnerID=MN8TOARS.
    10.1371/journal.pone.0074908
  15. Merino, M.M.; Rhiner, C.; Portela, M.; Moreno, E.. ""Fitness fingerprints" mediate physiological culling of unwanted neurons in drosophila". Current Biology 23 14 (2013): 1300-1309. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880698410&partnerID=MN8TOARS.
    10.1016/j.cub.2013.05.053
  16. Petrova, E.; López-Gay, J.M.; Rhiner, C.; Moreno, E.. "Flower-deficient mice have reduced susceptibility to skin papilloma formation". DMM Disease Models and Mechanisms 5 4 (2012): 553-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863483421&partnerID=MN8TOARS.
    10.1242/dmm.008623
  17. Rhiner, Christa; López-Gay, Jesús M.; Soldini, Davide; Casas-Tinto, Sergio; Martín, Francisco A.; Lombardía, Luis; Moreno, Eduardo. "Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila". Developmental Cell 18 6 (2010): 985-998. http://dx.doi.org/10.1016/j.devcel.2010.05.010.
    10.1016/j.devcel.2010.05.010
  18. Portela, M.; Casas-Tinto, S.; Rhiner, C.; López-Gay, J.M.; Domínguez, O.; Soldini, D.; Moreno, E.. "Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition". Developmental Cell 19 4 (2010): 562-573. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957863830&partnerID=MN8TOARS.
    10.1016/j.devcel.2010.09.004
  19. Ziv, O.; Suissa, Y.; Neuman, H.; Dinur, T.; Geuking, P.; Rhiner, C.; Portela, M.; et al. "The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling". Development 136 7 (2009): 1137-1145. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449128606&partnerID=MN8TOARS.
    10.1242/dev.032383
  20. Rhiner, C.; Díaz, B.; Portela, M.; Poyatos, J.F.; Fernández-Ruiz, I.; López-Gay, J.M.; Gerlitz, O.; Moreno, E.. "Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche". Development 136 6 (2009): 995-1006. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149139453&partnerID=MN8TOARS.
    10.1242/dev.033340
  21. Rhiner, C.; Moreno, E.. "Super competition as a possible mechanism to pioneer precancerous fields". Carcinogenesis 30 5 (2009): 723-728. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549144381&partnerID=MN8TOARS.
    10.1093/carcin/bgp003
  22. Su, C.-W.; Tharin, S.; Jin, Y.; Wightman, B.; Spector, M.; Meili, D.; Tsung, N.; et al. "The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans". Journal of Biology 5 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33847026886&partnerID=MN8TOARS.
    10.1186/jbiol39
  23. Rhiner, C.; Hengartner, M.O.. "Sugar antennae for guidance signals: Syndecans and glypicans integrate directional cues for navigating neurons". TheScientificWorldJournal 6 (2006): 1024-1036. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748974201&partnerID=MN8TOARS.
    10.1100/tsw.2006.202
  24. Rhiner, C.; Gysi, S.; Fröhli, E.; Hengartner, M.O.; Hajnal, A.. "Syndecan regulates cell migration and axon guidance in C. elegans". Development 132 20 (2005): 4621-4633. http://www.scopus.com/inward/record.url?eid=2-s2.0-27544440499&partnerID=MN8TOARS.
    10.1242/dev.02042
Livro
  1. Moreno, E.; Rhiner, C.; Soldini, D.. Expanding supercompetitors as a mechanism of field cancerization. 2011.
Tese / Dissertação
  1. "Anabel Rodriguez Simoes: Molecular mechanisms of neural stem cell activation following brain injury in Drosophila melanogaster". Doutoramento, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 2023.
  2. "Mariana Batista Santos. Elucidating mechanisms of damage-induced stem cell activation in the adult Drosophila brain". Doutoramento, Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, 2022.
  3. Rhiner, Christa. "Marta Lopes da Costa. Characterising novel regulators of injury-induced neural progenitor activation in the adult fly brain". Mestrado, Instituto Politécnico de Lisboa, 2021.
  4. Rhiner, Christa. "Andreia Sofia da Cunha Augusto. The role of injury - induced stress signalling for the activation of damage - responsive stem cells in the adult Drosophila melanogaster brain". Mestrado, Universidade do Minho, 2019.
  5. Alves, Carolina dos Santos. "Carolina Alves. Regenerative neurogenesis in Drosophila melanogaster: The influence of age and activity in the adult brain". Mestrado, 2017. http://hdl.handle.net/10400.12/6406.

Propriedade Intelectual

Patente
  1. EP12156256. 2012. "MAMMALIAN HOMOLOGUES OF FLOWER, THEIR USE IN CANCER DIAGNOSTICS, PREVENTION AND TREATMENT". Suiça.
    Concedida/Emitida
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/09/04 Unravelling conserved repair circuits in the fly brain Neurofly Conference
University of Birmingham (Birmingham, Reino Unido)
2024/06/20 Unravelling conserved repair circuits in the injured fly brain Drosophila as a model for brain disease research
Polish Academy of Sciences (Rome, Itália)
2024/04/19 Unravelling injury-driven circuits of stem cell activation
i3s Porto (Porto, Portugal)
2024/03/23 Unravelling conserved repair circuits in the brain XXVI Encontro Nacional de Estudantes de Biologia/ National Meeting of Biology Students
Organising Committee Portugues Biology Students (Lisbon, Portugal)
2023/09/12 Unravelling conserved repair circuits in the injured fly brain EPFL Symposium: Drosophila as a model to study neurodegeneration and brain immunity
EPFL Lausanne, Switzerland (Bruno Lemaitre) (Lausanne, Suiça)
2023/05/02 Neuro-glial clusters orchestrate regeneration in the injured fly brain VII Symposium of Portuguese Glial Network
FENS, Portuguese Glial Network (Albufeira, Portugal)
2022/11 Regeneration in the fly brain: Wake up signals for quiescent neural stem cells Aging and Challenges Congress
Skin Aging and Challenges committee, Paris (Lisbon, Portugal)
2022/10 Damage-responsive neuro-glial clusters coordinate the recruitment of dormant neural stem cells in Drosophila 19th International Congress of Developmental Biology
International Society of Developmental Biologists (Faro, Portugal)
2022/09 Tissue Damage and Repair in the Brain Co-Life meeting 2022
Gulbenkian Institute (Oeiras, Portugal)
2021/11 Injury-induced activation of quiescent neural progenitors in the adult fly brain 19th meeting of the Spanish Society of Neuroscience (SENC)
Spanish Society of Neuroscience (Lleida, Espanha)
2019/10 Brain regeneration in the fly: the power of damage-responsive neural stem cells PhD student course
Instituto Cajal , Madrid (Madrid, Espanha)
2019/10 Brain injury and Repair in Drosophila IUBMB Focused Meeting Tissue homeostasis in health and disease
Champalimaud Foundation (Lisbon, Portugal)
2018/11 modelling traumatic brain injury in Drosophila-Bilbao
Achucarro Basque Neuroscience Center (Bilbao, Espanha)
2017/09 The power of damage-responsive stem cells in Drosophila LMB Symposium, Cambridge
(Cambridge, Reino Unido)
Distinções

Prémio

2023 LaCaixa Health award in Neuroscience

Outra distinção

2006 Postdoctoral mobility fellowship, Swiss National Science Foundation
Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Suiça
2004 Competitive PhD fellowship University of Zurich
Universität Zürich, Suiça