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Sofia Lima (SL) is an Assistant Researcher in REQUIMTE, position awarded by the CEECIndividual 2017 call, and an Invited Assistant Professor at IUCS, Instituto Universitário de Ciências da Saúde, Portugal. Completed the PhD in Chemistry in 2007 at the Universidade do Porto Faculdade de Ciências, and the International Master of Science in Biotechnology in 1999 by De Montfort University, United Kingdom. SL graduated in Microbiology in 1998 by Universidade Católica Portuguesa Escola Superior de Biotecnologia. SL is focused in the study of cell-nanomaterials interactions using biochemical and biophysical techniques, to unravel related mechanisms of action. Improve knowledge on nanomaterials safety is crucial to assure their emerging introduction in consumer goods (food and health). SL interest in the development of drug delivery systems able to overcome the barriers (skin and gastrointestinal) lead to the exploitation of natural compounds as tools to enhance permeation and thus modulate biological processes. Published 75 articles in journals (75% Q1), 71 were published independently from SL's PhD supervisor and 28 as corresponding author. SL has an h-index of 23 (scopus) and was cited over 1450 times. SL is also the co-author of 1 book, 4 invited book chapters and a national patent. SL is the main supervisor of 2 PhD students and co-supervisor of 5. Supervised or co-supervised 15 MSc dissertation(s) and participated in the supervision of students (12) on a mobility program from Morocco, Italy, the United Kingdom, Croatia, Greece, Malasia and Turkey. Has received 4 awards and/or honors. Participates and/or participated as Principal investigator in 7 project(s) and Researcher in 16 project(s) funded by national or international funds. SL actively participates in COST Actions and in science awareness activities. SL participated in short-term scientific missions to different national and international laboratories in order to widen her scientific knowledge and know-how (e.g. Alba synchrotron, Barcelona). SL has been involved in several grant reviewing processes for international funding agencies (GWIS; NSC - Poland; ISF - Israel; University of Porto - Portugal; University Bordeaux and ANR - France; European Commission). Additionally, SL has been in the organization of Advanced Courses and Hands-on-Workshops. Works in the area(s) of Chemistry (mainly, polymer chemistry and colloidal chemistry) and Health Sciences with emphasis on Immunology and Nanomaterials for Pharmaceutical and Food applications. In her professional activities interacted with 340 collaborator(s) co-authorship of scientific papers. keywords: marine-based hydrogels; fucoidan/chitosan nanoparticles; mannosylated nanoparticles; gold nanoparticles; lipid nanoparticles; liposomes; cutaneous leishmaniasis; leprae; leishmaniose; sleeping sickness; atopic dermatitis; psoriasis; magnetic hyperthermia; nutraceuticals; pH-responsive nanoparticles; photodynamic therapy; PLA nanoparticles; PLGA nanoparticles; pegylated nanoparticles; theranostic nanoparticles.
Identificação

Identificação pessoal

Nome completo
Sofia Lima

Identificadores de autor

Ciência ID
0013-8CA6-2D1C
ORCID iD
0000-0001-8777-5877
Researcher Id
D-7026-2013
Scopus Author Id
36473881200

Moradas

  • REQUIMTE/ Applied Chemistry Laboratory, Department of Chemical Sciences, Faculty of Pharmacy of the University of Porto. Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Porto, Portugal (Profissional)

Websites

  • https://www.requimte.pt/laqv/people/sofia-antunes-costa-lima (Profissional)

Domínios de atuação

  • Ciências Exatas - Química - Ciência de Polímeros
  • Ciências Exatas - Química - Química de Colóides
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2007/11/07
Concluído
PhD in Chemistry (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
"Structural and functional activity of P-glycoprotein membrane transporter in the presence of benzodiazepines and tuberculostatic drugs. " (TESE/DISSERTAÇÃO)
Aprovado por unanimidade
1999/07/31
Concluído
International Master of Science in Biotechnology (Mestrado)
De Montfort University, Reino Unido
"Production of oral vaccines in "Solanum tuberosum L"" (TESE/DISSERTAÇÃO)
B+
1998/06/30
Concluído
Microbiology (Licenciatura)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
"Identification of "Serra da Estrela" Cheese isolated lactic bacteria by SDS-PAGE" (TESE/DISSERTAÇÃO)
14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/04/06 - Atual Investigador Auxiliar (carreira) (Investigação) REQUIMTE, Portugal
REQUIMTE LAQV Porto, Portugal
2016/04/06 - 2019/04/05 Investigador (Investigação) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
2013/03/18 - 2015/06/30 Investigador (Investigação) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
REQUIMTE, Portugal
2007/11/15 - 2013/03/17 Investigador (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2002/03/01 - 2007/11/07 Investigador (Investigação) REQUIMTE, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2021/09/25 - 2022/07/31 Professor Auxiliar Convidado (Docente Universitário) Instituto Universitário de Ciências da Saúde, Portugal
2020/09/14 - 2021/07/31 Professor Auxiliar Convidado (Docente Universitário) Instituto Universitário de Ciências da Saúde, Portugal
2019/10/01 - 2020/07/31 Professor Auxiliar Convidado (Docente Universitário) Instituto Universitário de Ciências da Saúde, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018/10/01 - 2019/02/28 Professor Auxiliar Convidado (Docente Universitário) Instituto Universitário de Ciências da Saúde, Portugal
2017/10/01 - 2018/02/28 Professor Auxiliar Convidado (Docente Universitário) Instituto Universitário de Ciências da Saúde, Portugal
2016/10/01 - 2017/02/28 Professor Auxiliar Convidado (Docente Universitário) Instituto Universitário de Ciências da Saúde, Portugal
2015/10/01 - 2016/02/28 Professor Auxiliar Convidado (Docente Universitário) Instituto Universitário de Ciências da Saúde, Portugal
Instituto Universitário de Ciências da Saúde, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2007/10/01 - 2008/06/30 Educational trainer Associação para a Escola Superior de Biotecnologia da Universidade Católica Portuguesa, Portugal
2007/03/01 - 2007/06/29 Educational trainer Forpime, Portugal
2000/03/01 - 2002/02/28 Invited Assistant Lecturer Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
1999/11/02 - 2001/12/31 Researcher Assistant Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
1999/02/01 - 1999/07/30 Graduated researcher Wageningen University and Research Wageningen Plant Research, Países Baixos
1997/10/01 - 1998/07/31 Undergraduated Researcher Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Projetos

Bolsa

Designação Financiadores
2002 - Atual Avaliação do efeito de iões de metais de transição no transporte de fármacos pela P-glicoproteína
PRAXIS XXI BD/4613/2001)
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
2002 - Atual Evaluation of the structure and function of P-glycoprotein, membrane transporter, in the presence of benzodiazepines and tuberculostatics
BPD/37880/2007
Bolseiro de Doutoramento
Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
1998 - Atual Production of oral vaccines in Solanum tuberosum L
PRAXIS XXI BM/20357/98
Bolseiro de Mestrado
Fundação para a Ciência e a Tecnologia
2008 - 2013/03/15 Development of BNIP polyamine drug delivery systems, liposome and nanoparticles, to target specially Leishmania infected macrophages and dendritic cells
BPD/37880/2007
Fundação para a Ciência e a Tecnologia
1998 - 2000/03/31 Mare Nostrum
Ministerio Defesa Nacional
Investigador
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Governo da Republica Portuguesa Ministério da Defesa Nacional
1999 - 1999/06/30 Production of oral vaccines in Solanum tuberosum L.
PRAXIS XXI BM/20357/98
Bolseiro de Mestrado
De Montfort University, Reino Unido
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2022 - 2023/12/31 CoSki - Collaborative Initiative for Skin Research
EEA Grant
Investigador responsável
REQUIMTE LAQV Porto, Portugal
EEA Grants
2022 - 2023/06/30 Cellulose-based iron nanofertilizers for sustainable growth of soybean plants
EXPL/QUI-QIN/0411/2021
Investigador
REQUIMTE LAQV Porto, Portugal
Fundação para a Ciência e a Tecnologia
2022 - 2023/03/31 Bacterial cell-specific targeting and nanoparticle-mediated bactericidal action against the most common pathogens colonizing diabetic foot ulcers
ESCMID Research Grants 2022
Investigador
Universidade do Minho, Portugal

REQUIMTE LAQV Porto, Portugal
European Society of Clinical Microbiology and Infectious Diseases
2022 - 2022/11/06 The effect of marine polymers-based nanoparticles on the skin structural organization towards skin delivery.
2021025041
Investigador responsável
Alba Synchroton
2018 - 2021/06/30 3Ds – transDermic aDministration of Drugs
PTDC/QUI-COL/30834/2017
Investigador responsável
REQUIMTE LAQV Porto, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/06/30 Circumventing surgical removal of biofilms infected implants: a nano-based, selective and targeted approach
PTDC/NAN-MAT/31444/2017
Investigador
REQUIMTE LAQV Porto, Portugal
Fundação para a Ciência e a Tecnologia
2020 - 2021/01/08 nano2Prevent
nano2Prevent
Investigador
REQUIMTE LAQV Porto, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2019/05/31 Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents
PTDC/MAR-BIO/4694/2014
Investigador
Fundação para a Ciência e a Tecnologia
2012 - 2015/05/04 Cell communication by Leishmania microvesicles
Provided by PTCRIS: 118644
Investigador
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
2012 - 2013/12 Therapeutic efficacy and safety of BNIPDaoct-loaded PLGA nanoparticles for the treatment of visceral leishmaniasis
IJUP2011-227
Banco Santander Totta
2011 - 2013/12 Development of new drug delivery systems based on bisnaphthalimidopropyl derivatives compounds liposomal formulation for pancreatic cancer and leishmaniasis drug therapy
Provided by PTCRIS: 113151
PTDC/ SAU-ENB/ 113151/ 2009
Investigador responsável
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
2011 - 2013/03/31 Development of a new immunological screening method for leishmaniasis using colloidal gold nanoparticles
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/110732/PT
Provided by PTCRIS: 110732
Investigador
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia

Fundação para a Ciência e a Tecnologia
2009 - 2012/12/31 Nanotechnology as a tool towards Leishmaniasis and Human African Trypanosomiasis therapy
P-105348
Investigador responsável
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação Calouste Gulbenkian
2011 - 2011/12/31 Evaluation of anti-Leishmania compounds released from polymeric nanoparticles
projeto 155
Investigador responsável
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Banco Santander Totta
2011 - 2011/12/31 Lipid nanocarriers for dermal and transdermal drug delivery intending the treatment of cellulite by inducing adipocytes lipolysis
Pluridisciplicar 98
Investigador
REQUIMTE LAQV Porto, Portugal
Banco Santander Totta
2006 - 2009/12/31 The Leishmania TDR1 family-related gene: functional studies and evaluation of TDR1 recombinant protein and knockout vaccines against leishmaniasis.
Provided by PTCRIS: 65047
PTDC/CVT/65047/2006
Investigador
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia

Outro

Designação Financiadores
2019 - 2025/04/03 SeaNano4sNTDs: Marine-based nanotechnological approaches for skin-related Neglected Tropical Diseases therapies
CEECIND/01620/2017
Investigador responsável
Fundação para a Ciência e a Tecnologia
2021 - 2022/05/31 C19-VisualDetect
C19-VisualDetect
Investigador
REQUIMTE LAQV Porto, Portugal
Universidade do Porto
2018 - 2022 CA16205: European Network on Understanding Gastrointestinal Absorption-related Processes (UNGAP)
CA16205
Investigador
European Cooperation in Science and Technology, Bélgica
European Cooperation in Science and Technology
2016 - 2019/03/30 FOODnanoHEALTH - Qualidade e Segurança Alimentar – uma abordagem (nano)tecnológica
NORTE-01-0145-FEDER-000011
Investigador
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Comissao de Coordenacao e Desenvolvimento Regional do Norte
2014 - 2018 CM1307 "Targeted chemotherapy towards diseases caused by endoparasites"
CM1307
Investigador
European Cooperation in Science and Technology, Bélgica
European Cooperation in Science and Technology
2014 - 2018 TD1402 "Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (RADIOMAG)"
TD1402
Investigador
European Cooperation in Science and Technology, Bélgica
European Cooperation in Science and Technology
2013 - 2015/06/30 Nanoquímica
Norte-07-0124-FEDER-000067
Investigador
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2012 - 2014 TD1004 "Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery"
TD 1004
Investigador
European Cooperation in Science and Technology, Bélgica
European Cooperation in Science and Technology
Produções

Publicações

Artigo em revista
  1. Tânia M. T. Guimarães; Tânia Moniz; Cláudia Nunes; Maya Margaritova Zaharieva; Mila Kaleva; Krassimira Yoncheva; Hristo Najdenski; Sofia A. Costa Lima; Salette Reis. "Polymeric Microneedles for Transdermal Delivery of Rivastigmine: Design and Application in Skin Mimetic Model". Pharmaceutics 14 4 (2022): 752-752. https://doi.org/10.3390/pharmaceutics14040752.
    10.3390/pharmaceutics14040752
  2. Adouni, Khaoula; Júlio, Ana; Santos-Buelga, Celestino; González-Paramás, Ana M.; Filipe, Patrícia; Rijo, Patricia; Costa Lima, Sofia A.; et al. "Roots and rhizomes of wild Asparagus: Nutritional composition, bioactivity and nanoencapsulation of the most potent extract". Food Bioscience 45 (2022): 101334. http://dx.doi.org/10.1016/j.fbio.2021.101334.
    Publicado • 10.1016/j.fbio.2021.101334
  3. Renata Basto; Raquel Andrade; Cláudia Nunes; Sofia A. Costa Lima; Salette Reis. "Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect". Pharmaceutics 13 11 (2021): 1968-1968. https://doi.org/10.3390/pharmaceutics13111968.
    10.3390/pharmaceutics13111968
  4. Tânia Moniz; Sofia A. Costa Lima; Salette Reis. "Protocol for the Isolation of Stratum Corneum from Pig Ear Skin: Evaluation of the Trypsin Digestion Conditions". Methods and Protocols (2021): https://doi.org/10.3390/mps4040080.
    10.3390/mps4040080
  5. Fonseca, Magda; Macedo, Ana S.; Lima, Sofia A. Costa; Reis, Salette; Soares, Raquel; Fonte, Pedro. "Evaluation of the Antitumour and Antiproliferative Effect of Xanthohumol-Loaded PLGA Nanoparticles on Melanoma". Materials 14 21 (2021): 6421. http://dx.doi.org/10.3390/ma14216421.
    Publicado • 10.3390/ma14216421
  6. Rita M. Pinto; Claudia Monteiro; Sofia A. Costa Lima; Susana Casal; Patrick Van Dijck; M. Cristina L. Martins; Cláudia Nunes; Salette Reis. "N-Acetyl-l-cysteine-Loaded Nanosystems as a Promising Therapeutic Approach Toward the Eradication of Pseudomonas aeruginosa Biofilms". ACS Applied Materials & Interfaces (2021): https://doi.org/10.1021/acsami.1c05124.
    10.1021/acsami.1c05124
  7. Raquel Costa; Sofia A. Costa Lima; Paula Gameiro; Salette Reis. "On the Development of a Cutaneous Flavonoid Delivery System: Advances and Limitations". Antioxidants 10 9 (2021): 1376-1376. https://doi.org/10.3390/antiox10091376.
    10.3390/antiox10091376
  8. Joana Costa Antunes; Catarina Leal Seabra; Joana Margarida Domingues; Marta Oliveira Teixeira; Cláudia Nunes; Sofia Antunes Costa-Lima; Natália Cândido Homem; et al. "Drug Targeting of Inflammatory Bowel Diseases by Biomolecules". Nanomaterials 11 8 (2021): 2035-2035. https://doi.org/10.3390/nano11082035.
    10.3390/nano11082035
  9. Moniz, Tânia; Costa Lima, Sofia A.; Reis, Salette. "Marine polymeric microneedles for transdermal drug delivery". Carbohydrate Polymers 266 (2021): 118098. http://dx.doi.org/10.1016/j.carbpol.2021.118098.
    Publicado • 10.1016/j.carbpol.2021.118098
  10. Ana Isabel Barbosa; Tiago Torres; Sofia A. Costa Lima; Salette Reis. "Hydrogels: A Promising Vehicle for the Topical Management of Atopic Dermatitis". Advanced Therapeutics (2021): https://doi.org/10.1002/adtp.202100028.
    10.1002/adtp.202100028
  11. Sofia A. Costa Lima; Salette Reis. "Polymeric Carriers for Biomedical and Nanomedicine Application". Polymers 13 8 (2021): 1261-1261. https://doi.org/10.3390/polym13081261.
    10.3390/polym13081261
  12. Vieira, Alexandre C.C.; Chaves, Luíse L.; Pinheiro, Marina; Lima, Sofia Costa; Neto, Pedro José Rolim; Ferreira, Domingos; Sarmento, Bruno; Reis, Salette. "Lipid nanoparticles coated with chitosan using a one-step association method to target rifampicin to alveolar macrophages". Carbohydrate Polymers 252 (2021): 116978. http://dx.doi.org/10.1016/j.carbpol.2020.116978.
    Aceite para publicação • 10.1016/j.carbpol.2020.116978
  13. Moraes, S.; Marinho, A.; Lima, S.; Granja, A.; Araújo, J.P.; Reis, S.; Sousa, C.T.; Nunes, C.. "Targeted nanostructured lipid carriers for doxorubicin oral delivery". International Journal of Pharmaceutics 592 (2021): 120029. http://dx.doi.org/10.1016/j.ijpharm.2020.120029.
    Publicado • 10.1016/j.ijpharm.2020.120029
  14. Raquel G. D. Andrade; Bruno Reis; Benjamin Costas; Sofia A. Costa Lima; Salette Reis. "Modulation of Macrophages M1/M2 Polarization Using Carbohydrate-Functionalized Polymeric Nanoparticles". Polymers 13 1 (2020): 88-88. https://doi.org/10.3390/polym13010088.
    10.3390/polym13010088
  15. Luíse L. Chaves; Yuri Patriota; José L. Soares-Sobrinho; Alexandre C. C. Vieira; Sofia A. Costa Lima; Salette Reis. "Drug Delivery Systems on Leprosy Therapy: Moving Towards Eradication?". Pharmaceutics (2020): https://doi.org/10.3390/pharmaceutics12121202.
    10.3390/pharmaceutics12121202
  16. Moniz, Tânia; Costa Lima, Sofia A.; Reis, Salette. "Application of the human stratum corneum lipid-based mimetic model in assessment of drug-loaded nanoparticles for skin administration". International Journal of Pharmaceutics 591 (2020): 119960. http://dx.doi.org/10.1016/j.ijpharm.2020.119960.
    Publicado • 10.1016/j.ijpharm.2020.119960
  17. Ludovico Esposito; Ana Isabel Barbosa; Tânia Moniz; Sofia Costa Lima; Paulo Costa; Christian Celia; Salette Reis. "Design and Characterization of Sodium Alginate and Poly(vinyl) Alcohol Hydrogels for Enhanced Skin Delivery of Quercetin". Pharmaceutics (2020): https://doi.org/10.3390/pharmaceutics12121149.
    10.3390/pharmaceutics12121149
  18. Ong, Yong Sze; Bañobre-López, Manuel; Costa Lima, Sofia A.; Reis, Salette. "A multifunctional nanomedicine platform for co-delivery of methotrexate and mild hyperthermia towards breast cancer therapy". Materials Science and Engineering: C 116 (2020): 111255. http://dx.doi.org/10.1016/j.msec.2020.111255.
    10.1016/j.msec.2020.111255
  19. Daniela Resende; Sofia A. Costa Lima; Salette Reis. "Nanoencapsulation approaches for oral delivery of vitamin A". Colloids and Surfaces B: Biointerfaces (2020): 111121-111121. https://doi.org/10.1016/j.colsurfb.2020.111121.
    10.1016/j.colsurfb.2020.111121
  20. Moniz, Tânia; Costa Lima, Sofia A.; Reis, Salette. "Human skin models: From healthy to disease-mimetic systems; characteristics and applications". British Journal of Pharmacology (2020): http://dx.doi.org/10.1111/bph.15184.
    10.1111/bph.15184
  21. Oliver, Miquel; Kudlak, Blazej; Wieczerzak, Monika; Reis, Salette; Lima, Sofia A.C.; Segundo, Marcela A.; Miró, Manuel. "Ecotoxicological equilibria of triclosan in Microtox, XenoScreen YES/YAS, Caco2, HEPG2 and liposomal systems are affected by the occurrence of other pharmaceutical and personal care emerging contaminants". Science of The Total Environment 719 (2020): 137358. http://dx.doi.org/10.1016/j.scitotenv.2020.137358.
    10.1016/j.scitotenv.2020.137358
  22. Maria Inês Silva; Ana Isabel Barbosa; Sofia A. Costa Lima; Paulo Costa; Tiago Torres; Salette Reis; Silva, Maria Inês; et al. "Freeze-Dried Softisan® 649-Based Lipid Nanoparticles for Enhanced Skin Delivery of Cyclosporine A". Nanomaterials 10 5 (2020): 986-986. https://doi.org/10.3390/nano10050986.
    10.3390/nano10050986
  23. Marques, Sara S.; Ramos, Inês I.; Fernandes, Sara R.; Barreiros, Luisa; Lima, Sofia A. C.; Reis, Salette; Domingues, M. Rosário M.; Segundo, Marcela A.. "Insights on Ultrafiltration-Based Separation for the Purification and Quantification of Methotrexate in Nanocarriers". Molecules 25 8 (2020): 1879. http://dx.doi.org/10.3390/molecules25081879.
    10.3390/molecules25081879
  24. Coutinho, A.J.; Costa Lima, S.A.; Afonso, C.M.M.; Reis, S.. "Mucoadhesive and pH responsive fucoidan-chitosan nanoparticles for the oral delivery of methotrexate". International Journal of Biological Macromolecules 158 (2020): 180-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084220190&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2020.04.233
  25. Ana Isabel Barbosa; Ana Joyce Coutinho; Sofia A. Costa Lima (corresponding author); Salette Reis. "Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field". Marine Drugs 17 12 (2019): 654-654. https://doi.org/10.3390/md17120654.
    Publicado • 10.3390/md17120654
  26. Shakel, Zinaida; Nunes, Cláudia; Reis, Salette. "Development of a novel human stratum corneum model, as a tool in the optimization of drug formulations". International Journal of Pharmaceutics 569 (2019): 118571. http://dx.doi.org/10.1016/j.ijpharm.2019.118571.
    Publicado • 10.1016/j.ijpharm.2019.118571
  27. Abderrazzaq Essaghraoui; Ahmed Belfkira; Bassou Hamdaoui; Cláudia Nunes; Sofia A. Costa Lima (corresponding author); Salette Reis. "Improved Dermal Delivery of Cyclosporine A Loaded in Solid Lipid Nanoparticles". Nanomaterials (2019): https://doi.org/10.3390/nano9091204.
    10.3390/nano9091204
  28. João C. Campos; Domingos C. Ferreira; Sofia Lima; Salette Reis; Paulo J. Costa. "Swellable polymeric particles for the local delivery of budesonide in oral mucositis". International Journal of Pharmaceutics 566 (2019): 126-140. https://doi.org/10.1016/j.ijpharm.2019.05.057.
    10.1016/j.ijpharm.2019.05.057
  29. Ana Isabel Barbosa; Sofia A. Costa Lima (corresponding author); Salette Reis. "Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation". International Journal of Biological Macromolecules (2019): https://doi.org/10.1016/j.ijbiomac.2018.12.014.
    10.1016/j.ijbiomac.2018.12.014
  30. Barbosa, A.I.; Costa Lima, S.A. (corresponding author); Reis, S.. "Application of pH-responsive fucoidan/chitosan nanoparticles to improve oral quercetin delivery". Molecules 24 2 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060092617&partnerID=MN8TOARS.
    10.3390/molecules24020346
  31. Lopes-De-Campos, D.; Pinto, R.M.; Costa Lima, S.A.; Santos, T.; Sarmento, B.; Nunes, C.; Reis, S.. "Delivering amoxicillin at the infection site-a rational design through lipid nanoparticles". International Journal of Nanomedicine 14 (2019): 2781-2795. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065589930&partnerID=MN8TOARS.
    10.2147/IJN.S193992
  32. Barbosa, A.I.; Fernandes, S.R.; Machado, S.; Sousa, P.; Sze, O.Y.; Silva, E.M.P.; Barreiros, L.; et al. "Fast monolith-based chromatographic method for determination of methotrexate in drug delivery studies". Microchemical Journal 148 (2019): 185-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065077944&partnerID=MN8TOARS.
    10.1016/j.microc.2019.04.075
  33. Chaves, L.L.; Silveri, A.; Vieira, A.C.C.; Ferreira, D.; Cristiano, M.C.; Paolino, D.; Di Marzio, L.; et al. "pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization". International Journal of Biological Macromolecules 133 (2019): 1268-1279. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065421875&partnerID=MN8TOARS.
    10.1016/j.ijbiomac.2019.04.178
  34. Júlio, A.; Caparica, R.; Costa Lima, S.A.; Fernandes, A.S.; Rosado, C.; Prazeres, D.M.F.; Reis, S.; De Almeida, T.S.; Fonte, P.. "Ionic liquid-polymer nanoparticle hybrid systems as new tools to deliver poorly soluble drugs". Nanomaterials 9 8 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074534554&partnerID=MN8TOARS.
    10.3390/nano9081148
  35. Júlio, A.; Costa Lima, S.A.; Reis, S.; Santos de Almeida, T.; Fonte, P.. "Development of ionic liquid-polymer nanoparticle hybrid systems for delivery of poorly soluble drugs". Journal of Drug Delivery Science and Technology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060944790&partnerID=MN8TOARS.
    10.1016/j.jddst.2019.01.030
  36. Spirou SV; Costa Lima SA; Bouziotis P; Vranješ-Djuric S; Efthimiadou E¿; Laurenzana A; Barbosa AI; et al. "Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy.". Nanomaterials (Basel, Switzerland) (2018): http://europepmc.org/abstract/med/29734795.
    10.3390/nano8050306
  37. Chaves LL; Costa Lima SA; Vieira ACC; Barreiros L; Segundo MA; Ferreira D; Sarmento B; Reis S. "Nanosystems as modulators of intestinal dapsone and clofazimine delivery.". Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2018): http://europepmc.org/abstract/med/29864923.
    10.1016/j.biopha.2018.04.195
  38. Gouveia VM; Lopes-de-Araújo J; Costa Lima SA; Nunes C; Reis S. "Hyaluronic acid-conjugated pH-sensitive liposomes for targeted delivery of prednisolone on rheumatoid arthritis therapy.". Nanomedicine (London, England) (2018): http://europepmc.org/abstract/med/29790395.
    10.2217/nnm-2017-0377
  39. Alexandre C. C. Vieira; Luíse L. Chaves; Marina Pinheiro; Sofia A. Costa Lima; Domingos Ferreira; Bruno Sarmento; Salette Reis. "Mannosylated solid lipid nanoparticles for the selective delivery of rifampicin to macrophages". Artificial Cells, Nanomedicine, and Biotechnology (2018): https://doi.org/10.1080/21691401.2018.1434186.
    10.1080/21691401.2018.1434186
  40. Luíse L. Chaves; Sofia Lima; Alexandre C. C. Vieira; Domingos Ferreira; Bruno Sarmento; Salette Reis. "Overcoming clofazimine intrinsic toxicity: statistical modelling and characterization of solid lipid nanoparticles". Journal of The Royal Society Interface (2018): https://doi.org/10.1098/rsif.2017.0932.
    10.1098/rsif.2017.0932
  41. Moskvin, M.; Babic, M.; Reis, S.; Cruz, M.M.; Ferreira, L.P.; Carvalho, M.D.; Lima, S.A.C.; Horák, D.. "Biological evaluation of surface-modified magnetic nanoparticles as a platform for colon cancer cell theranostics". Colloids and Surfaces B: Biointerfaces 161 (2018): 35-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032858139&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2017.10.034
  42. Chaves, L.L.; Costa Lima, S.A.; Vieira, A.C.C.; Barreiros, L.; Segundo, M.A.; Ferreira, D.; Sarmento, B.; Reis, S.. "Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeability". European Journal of Pharmaceutical Sciences 112 (2018): 28-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033398806&partnerID=MN8TOARS.
    10.1016/j.ejps.2017.11.004
  43. Cavalcanti, S.M.T.; Nunes, C.; Costa Lima, S.A.; Soares-Sobrinho, J.L.; Reis, S.. "Optimization of nanostructured lipid carriers for Zidovudine delivery using a microwave-assisted production method". European Journal of Pharmaceutical Sciences 122 (2018): 22-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048987574&partnerID=MN8TOARS.
    10.1016/j.ejps.2018.06.017
  44. Machado, S.; Fernandes, S.R.; Chaves, L.L.; Lima, S.A.C.; Silva, E.M.P.; Barreiros, L.; Reis, S.; Segundo, M.A.. "Chromatographic method for the simultaneous quantification of dapsone and clofazimine in nanoformulations". Journal of Separation Science 41 17 (2018): 3382-3388. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051109733&partnerID=MN8TOARS.
    10.1002/jssc.201800427
  45. Lima, Sofia; Vieira, A.C.C.; Chaves, L.L.; Pinheiro, S.; Pinto, S.; Pinheiro, M.; Lima, S.C.; et al. "Mucoadhesive chitosan-coated solid lipid nanoparticles for better management of tuberculosis.". Int J Pharm. 536 1 (2017): 478-485. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037993500&partnerID=MN8TOARS.
    doi: 10.1016/j.ijpharm.2017.11.071
  46. Sofia A. Costa Lima; André Gaspar; Salette Reis; Luísa Durães. "Multifunctional nanospheres for co-delivery of methotrexate and mild hyperthermia to colon cancer cells". Materials Science and Engineering: C 75 (2017): 1420-1426. https://doi.org/10.1016/j.msec.2017.03.049.
    10.1016/j.msec.2017.03.049
  47. Ana Rute Neves; Joana Fontes Queiroz; Sofia A. Costa Lima; Salette Reis. "Apo E-Functionalization of Solid Lipid Nanoparticles Enhances Brain Drug Delivery: Uptake Mechanism and Transport Pathways". Bioconjugate Chemistry 28 4 (2017): 995-1004. https://doi.org/10.1021/acs.bioconjchem.6b00705.
    10.1021/acs.bioconjchem.6b00705
  48. Gaspar, A.S.; Wagner, F.E.; Amaral, V.S.; Costa Lima, S.A.; Khomchenko, V.A.; Santos, J.G.; Costa, B.F.O.; Durães, L.. "Development of a biocompatible magnetic nanofluid by incorporating SPIONs in Amazonian oils". Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 172 (2017): 135-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963819416&partnerID=MN8TOARS.
    10.1016/j.saa.2016.04.022
  49. Chaves, L.L.; Costa Lima, S.A.; Vieira, A.C.; Barreiros, L.; Segundo, M.A.; Ferreira, D.; Sarmento, B.; Reis, S.. "PH-sensitive nanoparticles for improved oral delivery of dapsone: Risk assessment, design, optimization and characterization". Nanomedicine 12 16 (2017): 1975-1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026748544&partnerID=MN8TOARS.
    10.2217/nnm-2017-0105
  50. Ferreira, M.; Barreiros, L.; Segundo, M.A.; Torres, T.; Selores, M.; Reis, S.. "Topical co-delivery of methotrexate and etanercept using lipid nanoparticles: A targeted approach for psoriasis management". Colloids and Surfaces B: Biointerfaces 159 (2017): 23-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026661669&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2017.07.080
  51. Cavalcanti, S.M.T.; Nunes, C.; Lima, S.A.C.; Soares-Sobrinho, J.L.; Reis, S.. "Multiple Lipid Nanoparticles (MLN), a New Generation of Lipid Nanoparticles for Drug Delivery Systems: Lamivudine-MLN Experimental Design". Pharmaceutical Research 34 6 (2017): 1204-1216. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015624217&partnerID=MN8TOARS.
    10.1007/s11095-017-2136-0
  52. Silva, E.; Barreiros, L.; Segundo, M.A.; Costa Lima, S.A. (corresponding author); Reis, S.. "Cellular interactions of a lipid-based nanocarrier model with human keratinocytes: Unravelling transport mechanisms". Acta Biomaterialia 53 (2017): 439-449. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010934600&partnerID=MN8TOARS.
    10.1016/j.actbio.2017.01.057
  53. Mara Ferreira; Elisabete Silva; Luísa Barreiros; Marcela A. Segundo; Sofia A. Costa Lima; Salette Reis. "Methotrexate loaded lipid nanoparticles for topical management of skin-related diseases: Design, characterization and skin permeation potential". International Journal of Pharmaceutics 512 1 (2016): 14-21. https://doi.org/10.1016/j.ijpharm.2016.08.008.
    10.1016/j.ijpharm.2016.08.008
  54. Segundo, Marcela A.; Abreu, Vera L. R. G.; Osorio, Marcelo V.; Nogueira, Sonia; Lin, Paul Kong Thoo; Cordeiro-da-Silva, Anabela; Lima, Sofia A. C.. "Development and validation of HPLC method with fluorometric detection for quantification of bisnaphthalimidopropyldiaminooctane in animal tissues following administration in polymeric nanoparticles". Journal of Pharmaceutical and Biomedical Analysis 120 (2016): 290-296. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000370585700038&KeyUID=WOS:000370585700038.
    10.1016/j.jpba.2015.12.033
  55. Neves, Ana Rute; Queiroz, Joana Fontes; Costa Lima, Sofia A.; Figueiredo, Francisco; Fernandes, Rui; Reis, Salette. "Cellular uptake and transcytosis of lipid-based nanoparticles across the intestinal barrier: Relevance for oral drug delivery". Journal of Colloid and Interface Science 463 (2016): 258-265. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000366961400032&KeyUID=WOS:000366961400032.
    10.1016/j.jcis.2015.10.057
  56. Gouveia, V; Lima, Sofia; Nunes, Cláudia; Reis, Salette. "Non-biologic nanodelivery therapies for rheumatoid arthritis". Journal of Biomedical Nanotechnology (2015):
    10.1166/jbn.2015.2159
  57. Sofia A. Costa Lima (corresponding author); Salette Reis. "Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: A multi-drug system for theranostic in rheumatoid arthritis". Colloids and Surfaces B: Biointerfaces 133 (2015): 378-387. http://dx.doi.org/10.1016/j.colsurfb.2015.04.048.
    10.1016/j.colsurfb.2015.04.048
  58. Ferreira M; Chaves LL; Lima SA (corresponding author); Reis S. "Optimization of nanostructured lipid carriers loaded with methotrexate: a tool for inflammatory and cancer therapy.". (2015): http://europepmc.org/abstract/med/26169145.
    10.1016/j.ijpharm.2015.07.013
  59. Barros, D.; Lima, S.A.C. (corresponding author); Cordeiro-Da-Silva, A.. "Surface functionalization of polymeric nanospheres modulates macrophage activation: Relevance in Leishmaniasis therapy". Nanomedicine 10 3 (2015): 387-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923640156&partnerID=MN8TOARS.
    10.2217/nnm.14.116
  60. Costa Lima, S.A. (corresponding author); Silvestre, Ricardo; Barros, Daniela; Cunha, Joana; Dinis-Oliveira, R.; Cordeiro-da-Silva, Anabela. "Crucial CD8+ T-lymphocyte cytotoxic role in amphotericin B nanospheres efficacy against experimental visceral leishmaniasis". Nanomedicine: Nanotechnology, Biology and Medicine (2014): http://www.sciencedirect.com/science/article/pii/S1549963414000033#.
    10.1016/j.nano.2013.12.013
  61. Pinto, M.F.; Moura, C.C.; Nunes, C.; Segundo, M.A.; Costa Lima, S.A. (corresponding author); Reis, S.. "A new topical formulation for psoriasis: Development of methotrexate-loaded nanostructured lipid carriers". International Journal of Pharmaceutics 477 1-2 (2014): 519-526. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911935101&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2014.10.067
  62. Lima, Sofia. "Surface functionalization of polymeric nanospheres modulates macrophage activation – application in visceral leishmaniasis therapy.". (2014):
    10.2217/NNM.14.116
  63. Roussaki, M.; Hall, B.; Lima, S.C.; Da Silva, A.C.; Wilkinson, S.; Detsi, A.. "Synthesis and anti-parasitic activity of a novel quinolinone-chalcone series". Bioorganic and Medicinal Chemistry Letters 23 23 (2013): 6436-6441. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886946961&partnerID=MN8TOARS.
    10.1016/j.bmcl.2013.09.047
  64. Sofia A. Costa Lima. "Aurones: A Promising Heterocyclic Scaffold for the Development of Potent Antileishmanial Agents". International Journal of Medicinal Chemistry (2012): http://www.hindawi.com/journals/ijmc/2012/196921/.
    10.1155/2012/196921
  65. Mehdi, O.; Françoise, S.; Sofia, C.L.; Urs, G.; Kevin, Z.; Bernard, S.; Igor, S.; et al. "HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA)". Pancreatology 12 2 (2012): 146-155. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862163445&partnerID=MN8TOARS.
    10.1016/j.pan.2012.02.013
  66. Costa Lima, S.A. (corresponding author); Resende, M.; Silvestre, R.; Tavares, J.; Ouaissi, A.; Lin, P.K.T.; Cordeiro-Da-Silva, A.. "Characterization and evaluation of BNIPDaoct-loaded PLGA nanoparticles for visceral leishmaniasis: In vitro and in vivo studies". Nanomedicine 7 12 (2012): 1839-1849. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871263911&partnerID=MN8TOARS.
    10.2217/nnm.12.74
  67. Martins, S.; Costa-Lima, S.; Carneiro, T.; Cordeiro-Da-Silva, A.; Souto, E.B.; Ferreira, D.C.. "Solid lipid nanoparticles as intracellular drug transporters: An investigation of the uptake mechanism and pathway". International Journal of Pharmaceutics 430 1-2 (2012): 216-227. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860780308&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2012.03.032
  68. Costa Lima, S.A. (corresponding author); Rodrigues, V.; Garrido, J.; Borges, F.; Kong Thoo Lin, P.; Cordeiro Da Silva, A.. "In vitro evaluation of bisnaphthalimidopropyl derivatives loaded into pegylated nanoparticles against Leishmania infantum protozoa". International Journal of Antimicrobial Agents 39 5 (2012): 424-430. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859430685&partnerID=MN8TOARS.
    10.1016/j.ijantimicag.2012.01.003
  69. Vilas-Boas, V.; Silva, R.; Gaio, A.R.; Martins, A.M.; Lima, S.C.; Cordeiro-da-Silva, A.; de Lourdes Bastos, M.; Remião, F.. "P-glycoprotein activity in human Caucasian male lymphocytes does not follow its increased expression during aging". Cytometry Part A 79 A 11 (2011): 912-919. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054897494&partnerID=MN8TOARS.
    10.1002/cyto.a.21135
  70. Silva, R.; Carmo, H.; Dinis-Oliveira, R.; Cordeiro-Da-Silva, A.; Lima, S.C.; Carvalho, F.; De Lourdes Bastos, M.; Remião, F.. "In vitro study of P-glycoprotein induction as an antidotal pathway to prevent cytotoxicity in Caco-2 cells". Archives of Toxicology 85 4 (2011): 315-326. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954426149&partnerID=MN8TOARS.
    10.1007/s00204-010-0587-8
  71. Lin, P.K.T.; Hoskins, C.; Ouaissi, M.; Lima, S.C.; Cheng, W.P.; Loureirio, I.; Mas, E.; et al. "In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer". Pharmaceutical Research 27 12 (2010): 2694-2703. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651326311&partnerID=MN8TOARS.
    10.1007/s11095-010-0268-6
  72. Lima, S.A.C.; Tavares, J.; Gameiro, P.; de Castro, B.; Cordeiro-da-Silva, A.. "Flurazepam inhibits the P-glycoprotein transport function: An insight to revert multidrug-resistance phenotype". European Journal of Pharmacology 581 1-2 (2008): 30-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-38549114108&partnerID=MN8TOARS.
    10.1016/j.ejphar.2007.11.045
  73. Lima, S.A.C.; Cordeiro-Da-Silva, A.; De Castro, B.; Gameiro, P.. "Benzodiazepine-mediated structural changes in the multidrug transporter P-glycoprotein: An intrinsic fluorescence quenching analysis". Journal of Membrane Biology 223 3 (2008): 117-125. http://www.scopus.com/inward/record.url?eid=2-s2.0-53849101372&partnerID=MN8TOARS.
    10.1007/s00232-008-9117-5
  74. Lima, S.A.C.; Cordeiro-da-Silva, A.; de Castro, B.; Gameiro, P.. "Sensitivity of P-glycoprotein tryptophan residues to benzodiazepines and ATP interaction". Biophysical Chemistry 125 1 (2007): 143-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750698584&partnerID=MN8TOARS.
    10.1016/j.bpc.2006.07.006
  75. Lima, S.A.C.; Cordeiro-Da-Silva, A.; Gameiro, P.; De Castro, B.. "A method for functional mouse MDR3 P-glycoprotein reconstitution in Escherichia coli lipids". Analytical Biochemistry 338 2 (2005): 350-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-14644420801&partnerID=MN8TOARS.
    10.1016/j.ab.2004.10.022
  76. Lima, S.A.C.; Raposo, M.F.J.; Castro, P.M.L.; Morais, R.M.. "Biodegradation of p-chlorophenol by a microalgae consortium". Water Research 38 1 (2004): 97-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345714784&partnerID=MN8TOARS.
    10.1016/j.watres.2003.09.005
  77. Lima, S.A.C.; Castro, P.M.L.; Morais, R.. "Biodegradation of p-nitrophenol by microalgae". Journal of Applied Phycology 15 2-3 (2003): 137-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038042051&partnerID=MN8TOARS.
    10.1023/A:1023877420364
Capítulo de livro
  1. Ana Isabel Barbosa; Raquel Costa; Tânia Moniz; Costa Lima, S.A.; Salette Reis. "Nanostrategies for skin delivery: tools for skin inflammatory diseases topical therapy". In The Road from Nanomedicine to Precision Medicine, editado por Shaker A Mousa; Raj Bawa; Gerald F Aude. Jenny Stanford, 2022.
    Em revisão
  2. Ana Isabel Barbosa; Filipa Serrasqueiro; Tânia Moniz; Costa Lima, S.A.; Salette Reis. "Marine polysaccharides for skin drug delivery: hydrogels and microneedles solutions". editado por Sougata Jana. Singapure: Springer Nature, 2022.
    Publicado
  3. Costa Lima, S A; Reis, Salette. "Nanotechnological Approaches in Drug Absorption through Skin Topical Delivery". In Nanoparticles in the Life Sciences and Biomedicine. Pan Stanford Publishing, 2018.
    Publicado
  4. Chaves, L L; Vieira, A.C.; Domingos, F; Sarmento, B; Reis, Salette; Costa Lima, S A. "Nanocarriers as a Strategy for Oral Bioavailability Improvement of Poorly Water-Soluble Drugs". In Nanoparticles in the Life Sciences and Biomedicine. Pan Stanford Publishing, 2018.
    Publicado
Edição de número de revista
  1. Costa Lima, S A; Reis, Salette. "Polymeric Carriers for Biomedical and Nanomedicine Application". Polymers (2020): https://www.mdpi.com/journal/polymers/special_issues/carrier_nanomedicine.
    Publicado • Editor convidado
Livro
  1. Polymeric Carriers for Biomedical and Nanomedicine Application. 2021.
    Publicado • Editor
Poster em conferência
  1. "Essential oil-enriched marine hydrogels for stratum corneum permeation enhancement". Trabalho apresentado em ChemBioGels 2021, 2021.
  2. "Topical delivery of niacinamide to skin using hybrid nanogels enhances photoprotection effect". Trabalho apresentado em ChemBioGels 2021, 2021.
  3. "Nutritive value and palatability of microalgae species in dog feeding". Trabalho apresentado em EAAP Annual Meeting 2021, 2021.
  4. "Synthesis of sugar-coated marine polymeric nanosystems for topical delivery of bioactive agents". Trabalho apresentado em 14th IJUP, 2021.
  5. Suellen Morais; Costa Lima, S A; Salette Reis; Claudia Nunes; Célia Sousa. "Iron-based Nanostructures Encapsulated in Lipid Nanoparticles as a Multifunctional Nanocarriers for doxorubicin controlled delivery". Trabalho apresentado em NALS 2020 - Nanomaterials Applied to Life Sciences, 2020.
  6. Tânia Moniz; Sedef Kaplan; Lima, Sofia; Salette Reis. "Chemical characterization of the PVPAsc model: the effect of surfactants and different pH on barrier permeability". Trabalho apresentado em Skin & Formulation Network, 2019.
  7. Simone Stefani; Ana Isabel Barbosa; Tânia Moniz; Sofia A. Costa Lima; Salette Reis. "Optimization of a nanoformulation for skin delivery: the influence of structure and composition". Trabalho apresentado em Skin & Formulation Network, 2019.
    10.1109/cise.2009.5365231
  8. Maria Inês Silva; Ana Isabel Barbosa; Lima, Sofia; Salette Reis. "A nanotechnological approach for the topical delivery of cyclosporine A". Trabalho apresentado em Skin & Formulation Network, Bath, 2019.
  9. Tânia Moniz; Simone Stefani; Ana Isabel Barbosa; Lima, Sofia; Salette Reis. "In vitro skin models: a novel lipid-based human stratum corneum mimetic model for the optimization of skin drug formulations". Trabalho apresentado em Skin Forum, Reims, 2019.
  10. Diana Araújo; Vitor Alves; Lima, Sofia; Filomena Freitas; Elvira Fortunato; Maria A. M. Reis. "Transdermal delivery systems based on natural polymeric biomaterials". Trabalho apresentado em Ciencia 2019, 2019.
  11. Ana Isabel Barbosa; Lima, Sofia; Salette Reis. "In vitro skin cellular model: a tool to unravel transport mechanisms and bioavailability". Trabalho apresentado em Advanced Summer School – Interrogations at the Biointerface, 2019.
  12. João Campos; Domingos Ferreira; Lima, Sofia; Salette Reis; Paulo Costa. "Local budesonide delivery using polymeric nanoparticles for oral mucositis management". Trabalho apresentado em 6th Nano Today Conference, 2019.
  13. Lima, Sofia; Ana Isabel Barbosa; Tânia Moniz; Cláudia Nunes; Salette Reis. "A novel human stratum corneum mimetic model, as a tool in the optimization of skin drug formulations". Trabalho apresentado em ETPN / NanoMed Europe, 2019.
  14. Mariana Romanholo; Ana Isabel Barbosa; Diana Resende; Lima, Sofia; Emília Sousa; Madalena Pinto; Salette Reis. "Marine nature as a source for cancer therapy: xanthone loaded fucoidan/chitosan nanoparticles". Trabalho apresentado em 12th IJUP, 2019.
  15. João Campos; Domingos Ferreira; Lima, Sofia; Salette Reis; Paulo Costa. "Development of budesonide polymeric mucoadhesive particles for the local management of oral mucositis". Trabalho apresentado em SPLC-CRS Santiago Compostela, 2019.
  16. Sara Marques; Inês Ramos; Sara Fernandes; Luísa Barreiros; Lima, Sofia; Salette Reis; Maria Domingues; Marcela A. Segundo. "Exploiting ultrafiltration for purification and characterization of drug-nanocarriers". Trabalho apresentado em Euroanalysis 2019, 2019.
  17. Zinaide Shakel; Claudia Nunes; Lima, Sofia; Salette Reis. "In Vitro Skin Models As A Tool In The Optimization Of Drug Formulation.". Trabalho apresentado em SFNano 2018, Montepellier, 2018.
  18. Sara Marques; Inês Ramos; Luísa Barreiros; Lima, Sofia; Salette Reis; Maria R. Domingues; Marcela A. Segundo. "Immunopurification of nanoparticles under lab-on-valve format Immunopurification of nanoparticles under lab-on-valve format.". Trabalho apresentado em Flow Analysis and Capillary Electrophoresis, Hradec Kralove, 2018.
  19. Sara Marques; Inês Ramos; Luísa Barreiros; Lima, Sofia; Salette Reis; Maria R. Domingues; Marcela A. Segundo. "Evaluation of encapsulation efficiency in methotrexate-loaded nanoparticles using separative methods". Trabalho apresentado em Analita 2018: 9th Meeting of the Analytical Chemistry Division, 2018.
  20. Sândia Machado; Sara Fernandes; Luíse Chaves; Sofia A. Costa Lima; Eduarda Silva; Luísa Barreiros; Salette Reis; Marcela A. Segundo. "Simultaneous determination of Dapsone and Clofazimine in nanoformulations by HPLC". Trabalho apresentado em Analita 2018: 9th Meeting of the Analytical Chemistry Division, 2018.
    10.1109/rsete.2011.5966191
  21. Joana Cardoso; Ana Isabel Barbosa; Lima, Sofia; Salette Reis. "Fucoidan/ Chitosan nanoparticles: the influence of type and amount of polysaccharides". Trabalho apresentado em 11st IJUP, 2018.
  22. Daniela Lopes-de-Campos; Rita M. Pinto; Catarina Seabra; Lima, Sofia; Cristina Martins; Cláudia Nunes; Salette Reis. "Amoxicillin-loaded lipid nanoparticles: towards a therapeutic approach for Helicobacter pylori infections". Trabalho apresentado em NanoBio&Med2017, 2017.
  23. Miguel Horta; Rita Leal; Lima, Sofia; Célia Sousa; J. P. Araújo; Salette Reis; Cláudia Nunes. "Paclitaxel loaded hybrid magnetic-lipid nanoparticles as a novel approach for cancer therapy". Trabalho apresentado em 1st BioBrillouin Meeting, 2017.
  24. Lima, Sofia; Salette Reis. "Co-delivery of gold nanoparticles and methotrexate in polymeric nanospheres for photothermal therapy". Trabalho apresentado em 1st BioBrillouin Meeting, 2017.
  25. Joana Cardoso; Ana Isabel Barbosa; Lima, Sofia; Salette Reis. "Development and characterization of Fucoidan/ Chitosan pH sensitive nanoparticles". Trabalho apresentado em 10th IJUP, 2017.
  26. Beatriz Costa; A. S. Gaspar; P. H. C. Santos; F. E. Wagner; Lima, Sofia; O. B. Ribeiro; L. Durães. "Development of biocompabible magnetic nanofluids for biomedical applications". Trabalho apresentado em 2nd International Conference on “Multifunctional Materials and their Applications”, 2017.
  27. Ana Isabel Barbosa; Lima, Sofia; Carlos Afonso; Salette Reis. "Optimization and characterization Chitosan/Fucoidan pH sensitive nanoparticles for delivery of methotrexate". Trabalho apresentado em XXII Encontro Luso-Galego de Química, 2016.
  28. Liliana Pereira; M. M. Cruz; M. L. Oliveira; S. G. Mendo; A. F. Alves; Salette Reis; Lima, Sofia; M. Godinho; M. D. Carvalho. "Decorated nanoparticles of magnetic hyperthermia.". Trabalho apresentado em 11th Inorganic Chemistry Conference, Portuguese Society of Chemistry, 2016.
  29. Luíse L. Chaves; Alexandre Vieira; Lima, Sofia; Domingos Ferreira; Bruno Sarmento; Salette Reis. "Solid lipid nanoparticles as strategy to improve clofazimine intestinal absorption: design, characterization and in vitro cytotoxicity studies". Trabalho apresentado em 7th International Congress Nanotechnology in Biology & Medicine - BioNanoMed, 2016.
  30. Lima, Sofia; Salette Reis. "Magnetic nanoparticle – cancer cell interactions: noninvasive assessment". Trabalho apresentado em RADIOMAG Annual Meeting, 2015.
  31. A. S. Gaspar; F. E. Wagner; V. S. Amaral; Lima, Sofia; J.G. Santos; B. F. O. Costa; L. Durães. "Development of a magnetic nanofluid by incorporating SPIONs in Amazonian oils". Trabalho apresentado em XXXIX CSI, 2015.
  32. P. Tibaldo; L. L. Chaves; Lima, Sofia; Salette Reis. "Optimization and characterization of methotrexate-loaded polymeric nanoparticles: a Box-Behnken design approach". Trabalho apresentado em 8th IJUP 2015, 2015.
  33. Mara Ferreira; Lima, Sofia; Salette Reis. "Optimization and characterization of lipid-based nanoparticles for topical therapy of psoriasis". Trabalho apresentado em NanoPT 2015, 2015.
  34. Mara Ferreira; Lima, Sofia; Salette Reis. "Optimization and development of nanostructure lipid carriers for topical therapy of psoriasis". Trabalho apresentado em Luso Galego 2014, 2014.
  35. Lima, Sofia; Salette Reis. "Theranostic nanospheres for localized photothermal therapy of Rheumatoid Arthritis.". Trabalho apresentado em ETP-Nanomedicine Annual Meeting 2014, 2014.
  36. Daniela Barros; Lima, Sofia; Anabela Cordeiro-da-Silva. "Surface functionalization of polymeric nanospheres modulates macrophage activation – application in visceral leishmaniasis therapy". Trabalho apresentado em Bioimaging 2014, 2014.
  37. Maria Pinto; Lima, Sofia; Salette Reis. "Methotrexate-loaded NLCs for psoriasis topical therapy: optimization, production and characterization". Trabalho apresentado em ANM 2014, 2014.
  38. Lima, Sofia; Salette Reis. "Methotrexate-loaded polymeric nanospheres containing Gold nanoparticles for localized photothermal therapy of Rheumatoid Arthritis". Trabalho apresentado em NanoBio-Europe, 2014.
  39. Lima, Sofia; Salette Reis. "Quantification of methotrexate released from drug delivery systems". Trabalho apresentado em Simpósio SPQ-Analítica 2014, 2014.
  40. Lima, Sofia; M. T. Baltazar; R. J. Dinis-Oliveira; Anabela Cordeiro-da-Silva. "Therapeutic efficacy and safety of BNIPDaoct-loaded PLGA nanoparticles for the treatment of visceral leishmaniasis". Trabalho apresentado em 7th IJUP 2014, 2014.
  41. Lima, Sofia; Salette Reis. "Preparation and characterization of polymeric nanospheres for rheumatoid arthritis treatment.". Trabalho apresentado em NanofolNanodiara Meeting - Nanoparticles for early Diagnostics of inflammatory diseases, 2013.
  42. A. R. Neves; Lima, Sofia; J. L. C. Lima; Salette Reis. "Nanoimaging of resveratrol-loaded lipid nanoparticles during caco-2 cell uptake". Trabalho apresentado em International Symposium in Applied Bioimaging 2013, 2013.
  43. M. V. Osório; S. Nogueira; Marcela A. Segundo; V. L. R. G. Abreu; Anabela Cordeiro-da-Silva; Lima, Sofia. "Assessment of an anti-Leishmania compound loaded on PLGA nanoparticles - in vitro and in vivo studies". Trabalho apresentado em 6th IJUP 2013, 2013.
  44. S. Nogueira; D. Barros; Anabela Cordeiro-da-Silva; Lima, Sofia. "Unraveling the mechanism of action of BNIPDiaminooctane on Leishmania infantum parasites – target identification and development of resistant strain.". Trabalho apresentado em 6th IJUP 2013, 2013.
  45. Daniela Barros; Anabela Cordeiro-da-Silva; Lima, Sofia. "Immunotherapeutic potential of mannosylated nanoparticles". Trabalho apresentado em XXXVIII Annual Meeting of the Portuguese Society of Immunology, 2012.
  46. M. Ouaissi; F. Silvy; Lima, Sofia; B. Sastre; I. Sielezneff; Anabela Cordeiro-da-Silva; D. Lombardo; E. Mas; A. Ouaissi. "HDAC gene expression in pancreatic tumor cell lines submitted to the probinostat or trichostatin HDAC Inhibitors". Trabalho apresentado em ESSR 2012 47th Annual Congress, 2012.
  47. Daniela Barros; Anabela Cordeiro-da-Silva; Lima, Sofia. "Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis". Trabalho apresentado em 3rd I3S scientific meeting, 2012.
  48. Patrícia Varela; P. K. T. Lin; Lima, Sofia; Anabela Cordeiro-da-Silva. "Drug screening of bisnaphthalimidopropyl derivatives on Trypanosoma brucei.". Trabalho apresentado em 3rd I3S scientific meeting, 2012.
  49. Daniela Barros; Anabela Cordeiro-da-Silva; Lima, Sofia. "Active targeting of macrophages by mannosylated nanoparticles loaded with amphotericin B towards visceral leishmaniasis therapy.". Trabalho apresentado em Colloids and Nanomedicine, 2012.
  50. Patrícia Varela; P. K. T. Lin; Anabela Cordeiro-da-Silva; Lima, Sofia. "In vitro screening of bisnaphthalimidopropyl derivatives on Trypanosoma brucei". Trabalho apresentado em British Society for Parasitology Spring Meeting 2012, 2012.
  51. M. Ouaissi; F. Silvy; Lima, Sofia; B. Sastre; I. Sielezneff; Anabela Cordeiro-da-Silva; D. Lombardo; E. Mas; A. Ouaissi. "Etude de l'efficacité panobinostat LBH 589 sur l’inhibition de la croissance des lignées cellulaires cancéreuses pancréatiques et la corrélation au niveau d’expression des HDAC". Trabalho apresentado em Journees Francophones d’Hepato-gastroenterologie et d’Oncologie Digestive 2012, 2012.
  52. Patrícia Varela; P. K. T. Lin; Anabela Cordeiro-da-Silva; Lima, Sofia. "Drug screening of bisnaphthalimidopropyl derivatives on Trypanosoma brucei". Trabalho apresentado em 5th IJUP’12, 2012.
  53. Daniela Barros; Lima, Sofia; Anabela Cordeiro-da-Silva. "Development and optimisation of targeted drug delivery systems towards visceral leishmaniasis". Trabalho apresentado em 5th IJUP’12, 2012.
  54. M. V. Osório; S. Nogueira; Marcela A. Segundo; V. L. R. G. Abreu; Anabela Cordeiro-da-Silva; Lima, Sofia. "Evaluation of anti-Leishmania compound released from polymeric nanoparticles". Trabalho apresentado em 5th IJUP’12, 2012.
  55. Marcela A. Segundo; V. L. R. G. Abreu; M. V. Osório; S. Nogueira; Anabela Cordeiro-da-Silva; Lima, Sofia. "Fluorimetric determination of bisnaphthalimidopropyldiaaminooctane by liquid chromatography using a monolithic column". Trabalho apresentado em 7º Encontro Nacional de Cromatografia, 2012.
  56. A. L. Robalo; J. A. Pereira; M. Resende; D, Moreira; J. Cunha; Lima, Sofia; Anabela Cordeiro-da-Silva. "Activation of IL-27p28 gene transcription on antigen presenting cells infected with Leishmania infantum". Trabalho apresentado em XXXVII SPI Annual Meeting, 2011.
  57. M. Ouaissi; F. Sylvi; Lima, Sofia; B. Sastre; I. Sielezneff; Anabela Cordeiro-da-Silva; E. Mas; A. Ouaissi. "Characterization of the anti-pancreatic tumor cell effect induced by LBH589 and its relation to HDAC encoding genes expression". Trabalho apresentado em Porto Cancer Meeting, 2011.
  58. K. Prousis; M. Roussaki; B. Hall; S. Wilkinson; Lima, Sofia; Anabela Cordeiro-da-Silva. "Novel antiparasitic agents based on the quinolinone heterocyclic scaffold". Trabalho apresentado em COST annual meeting, 2011.
  59. Lima, Sofia; V. Rodrigues; J. Garrido; F. Borges; P. K. T. Lin; Anabela Cordeiro-da-Silva. "Pegylated nanoparticles for encapsulation of bisnaphthalimidopropyl derivatives against Leishmania infantum". Trabalho apresentado em Trends in Nanotechnology, 2010.
  60. Lima, Sofia; M. Roussaki; S. Sampaio; A. Detsi; Anabela Cordeiro-da-Silva. "Determinação da actividade anti-Leishmania de compostos heterocíclicos por citometria de fluxo". Trabalho apresentado em XIV Congresso Português de Parasitologia, 2010.
  61. M. Roussaki; K. Prousis; Lima, Sofia; Anabela Cordeiro-da-Silva; A. Detsi. "Natural Product Analogues with anti - Leishmania infantum activity". Trabalho apresentado em 14th Hellenic Symposium on Medicinal Chemistry, 2010.
  62. S. Sampaio; Lima, Sofia; A. Detsi; Anabela Cordeiro-da-Silva. "Bioactivity of flavonoids against Leishmania infantum determined by flow cytometry". Trabalho apresentado em 3º Encontro de Jovens Investigadores da Universidade do Porto, 2010.
  63. Lima, Sofia; P. K. T. Lin; Anabela Cordeiro-da-Silva. "In vitro evaluation of bisnaphthalimidopropyl-derivatives loaded PLGA nanoparticles on Leishmania infected cells". Trabalho apresentado em 18th Conference on Inorganic Chemistry, 2009.
  64. Lima, Sofia; P. K. T. Lin. "Encapsulation of bisnaphthalimidopropyl derivatives, two novel anti-Leishmania drugs, in biodegradable PLA and PLGA nanoparticles". Trabalho apresentado em Nanomedicine 2008, 2008.
  65. R. Silva; Anabela Cordeiro-da-Silva; Lima, Sofia; F. Carvalho; M. L. Bastos; H. Carmo; F. Remião. "Effect of P-Glycoprotein inducers on its expression and activity in Caco-2 cells". Trabalho apresentado em 45th Eurotox Congress, 2008.
  66. Lima, Sofia; Anabela Cordeiro-da-Silva; B. de Castro; P. Gameiro. "Citometria de fluxo: um método para quantificar e identificar inibidores da P-glicoproteína". Trabalho apresentado em 6º Encontro Nacional de Química Analítica, 2006.
  67. Lima, Sofia; Anabela Cordeiro-da-Silva; B. de Castro; P. Gameiro. "Conformational changes of P-glycoprotein induced by drug - and nucleotide- binding". Trabalho apresentado em 4º Encontro do REQUIMTE, 2006.
  68. Lima, Sofia; Anabela Cordeiro-da-Silva; B. de Castro; P. Gameiro. "Intrinsic fluorescence of membrane transport proteins – sensitivity of Trp residues to binding of drugs". Trabalho apresentado em 1st European Conference on Chemistry for Life Sciences, 2005.
  69. Lima, Sofia; Anabela Cordeiro-da-Silva; B. de Castro; P. Gameiro. "A Resonance Energy Transfer study of the Rifampicin and RifampicinSV interaction with the multidrug transporter P-glycoprotein". Trabalho apresentado em 3rd Portuguese-Spanish Biophysics Congress, 2004.
  70. Lima, Sofia; Anabela Cordeiro-da-Silva; P. Gameiro; B. de Castro. "Intrinsic tryptophan fluorescence study of the interaction of benzodiazepines with P-glycoprotein.". Trabalho apresentado em Transporters 2004 – International Symposium on Membrane Transport and Transporters, 2004.
  71. Lima, Sofia; Anabela Cordeiro-da-Silva; P. Gameiro; B. de Castro. "Evaluation of the structure and function of the reconstituted P-glycoprotein multidrug transporter". Trabalho apresentado em 3º Encontro do REQUIMTE, 2004.
  72. Lima, Sofia; Anabela Cordeiro-da-Silva; P. Gameiro; B. de Castro. "Determinação do coeficiente de partição rifampicina/lipossomas por espectrofotometria derivative". Trabalho apresentado em 3º Encontro Nacional de Química Analítica, Escola Superior e Biotecnologia da Universidade Católica Portuguesa, 2003.
  73. Sofia A. Costa Lima; Forgac, Michael; P. Gameiro; B. de Castro. "Reconstitution of ATPase activity in proteoliposomes of mouse MDR3 P-glycoprotein.". Trabalho apresentado em XVII European Colloid and Interface Society Conference, 2003.
    10.1158/1535-7163.targ-15-a124
  74. Lima, Sofia; Anabela Cordeiro-da-Silva; P. Gameiro; B. de Castro. "Purificação da P-glicoproteína (MDR3) funcional a partir de células de Pichia pastoris". Trabalho apresentado em 1º Congresso da Sociedade Portuguesa de Ciências Farmacêuticas, 2003.
  75. Lima, Sofia; P. M. L. Castro; R. M. Morais. "Degradation of and p-nitrophenol by a cyanobacteria consortium". Trabalho apresentado em 10th European Congress in Biotechnology, 2001.
  76. Lima, Sofia; R. H. Pires; F. Tavaria; F. X. Malcata. "Characterisation of bacterial isolates from Serra da Estrela Cheese via analysis of their electrophoretic protein profiles.". Trabalho apresentado em BIOTEC'98 – IV Congresso Ibérico de Biotecnologia e I Encontro Ibero-Americano de Biotecnologia, 1998.
Tese / Dissertação
  1. Costa Lima, S A. "Evaluation of the structure and function of P-glycoprotein, membrane transporter, in the presence of benzodiazepines and tuberculostatics". Doutoramento, Universidade do Porto Faculdade de Ciências, 2007.
  2. Costa Lima, S A. "Production of oral vaccines in Solanum tuberosum L.". Mestrado, De Montfort University, 1999.

Propriedade Intelectual

Pedido provisório de patente
  1. 2021. "Colorimetric nanosensor for SARS-CoV-2 (NPAT404/2020)".
    Divulgado
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/11/08 Human stratum corneum lipid-based mimetic model: a tool to study drugs' permeability 3rd E-Meeting on Polymer Science & Biomaterials (Polybiomat-2021)
2021/10/20 Nanoparticles to prevent SARS-CoV-2 transmission Modtissimo - Scientific Developments Regarding Protection Against Pathogens such as Sars-Cov-2 (online conference)
CITEVE (Portugal)
2021/09/17 Breaking the barrier: N-acetyl-cysteine-loaded nanoparticles as a strategy to disrupt bacterial biofilms ESB 2021 – 31ST Conference of the European Society for Biomaterials.
European Society for Biomaterials. (Espanha)
2021/06/17 Understanding Cell-Nanoparticle Interaction: a new gateway to disease therapeutics XVII Congress of Iberian Society of Flow Citometry
Instituto Português de Oncologia do Porto
2021/05/06 Optimization of topical delivery for niacinamide using hydrogels and transethosomes 14th IJUP
University of Porto
2021/02/22 Nanotechnological approaches to STOP SARS-CoV-2 transmission JorTec DCM – Jornadas Tecnológicas do Departamento de Ciência dos Materiais
Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, online conference
2020/11/18 Overcoming the skin barrier: in vitro models and nanostrategies to enhance drug absorption Webinar @ Lunch
University of Florence
2020 Quercetin-loaded Hydrogels for Skin Ageing and Inflammation NanoPT
2019/11/22 Fucoidan/chitosan nanoparticles: delivery system for synthetized xanthone towards a in cancer therapy Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto, Porto
Faculdade de Farmácia da Universidade do Porto, Porto (por, Portugal)
2019/06/12 Unravelling drug’s permeation and transport mechanisms of lipid nanocarriers using in vitro skin models EUFEPS Open Forum
(Bonn, Alemanha)
2018/11/22 Topical delivery of cyclosporine A using lipid nanoparticles XXIV Encontro Luso-Galego
Faculty of Science, University of Porto (Porto, Portugal)
2018/11/22 Fighting bacterial resistance: a novel nanosystem for N-acetyl-cysteine (NAC) delivery XXIV Encontro Luso-Galego
University of Porto (po, Portugal)
2018/11/21 Targeting and killing the ever-challenge ulcer bug XXIV Encontro Luso-Galego
Faculty of Science, University of Porto (Porto, Portugal)
2018/02/12 Topical delivery of methotrexate using Fucoidan/Chitosan nanoparticles 11st IJUP
University of Porto (Porto, Portugal)
2018/02/08 Development and characterization of pH sensitive fucoidan-chitosan nanoparticles for oral delivery of methotrexate 11st IJUP
University of Porto (po, Portugal)
2018/02/08 Vitamin A encapsulation in lipid nanoparticles for food applications: development, characterization and stability 11st IJUP
University of Porto (Porto, Portugal)
2018/02/08 Cyclosporine A-loaded solid lipid nanoparticles for topical application 11st IJUP
Universidade do Porto (Porto, Portugal)
2018/02/08 Preparation and characterization of nanostructured lipid carriers for methotrexate delivery into breast-cancer cells – a hyperthermia approach. 11st IJUP
Universidade do Porto (Porto, Portugal)
2017/12/07 Chromatographicc analysis of biological samples using monolithic columns. 10th Encontro Nacional de Cromatografia
(Bragança, Portugal)
2017/11/16 Nanoplatforms as diagnostic and therapeutic tools. Conference + Bioquímica
Faculty of Science and Technology, Lisbon (Lisboa, Portugal)
2017/11/16 Application of lipid nanoparticles containing vitamin A in food: development and physico-chemical stability studies. XXIII Encontro Galego-Português de Quimica
(Ferrol, Espanha)
2017/02/09 Chitosan/Fucoidan pH sensitive nanoparticles for delivery of methotrexate 10th IJUP-Encontro Investigação Jovem da Universidade do Porto 2017
University of Porto (po, Portugal)
2017/02/08 Development of Cyclosporine A-loaded lipid nanoparticles (LN) formulations for topical application 10th IJUP-Encontro Investigação Jovem da Universidade do Porto 2017
University of Porto (Porto, Portugal)
2017/02/03 Cyclosporine A-loaded solid lipid nanoparticles versus nanostructured lipid carriers for dermal applications NanoPT 2017
(Porto, Portugal)
2017/02/02 Amoxicillin-loaded lipid nanoparticles: a novel approach to treat Helicobacter pylori infections NanoPT 2017
(por, Portugal)
2016/11/10 Development and optimization of amoxicillin-loaded lipid nanoparticles as a therapeutic approach for Helicobacter pylori infections XXII Encontro Luso-Galego de Química
(Bragança, Portugal)
2016/11/09 Development and validation of HPLC method for quantification of dapsone and clofazimine loaded nanoparticles upon bioavailability assessment XXII Encontro Luso-Galego de Química
(Bragança, Portugal)
2016/03/06 Challenges and Advances in Oral Drug Delivery using Lipid-based Nanoparticles. Pharmaceutica 2016
(Madrid, Espanha)
2016/02/18 Nanostructured Lipid Carriers: a new approach for Psoriasis topical therapy NanoPT 2016
(Braga, Portugal)
2015/11/20 Identification of keratinocytes’ interaction with nanostructured lipid carriers II Congresso Internacional de Saúde Gaia-Porto
Escola Superior de Saúde (Vila Nova de Gaia, Portugal)
2015/05/14 Application of box-behnken design to optimize methotrexate loaded nanostructured lipid nanoparticles 8th IJUP- Encontro Investigação Jovem da Universidade do Porto 2015
Universidade do Porto (Porto, Portugal)
2015/04/18 Why and how to assess the toxicity at the cell scale of new nanoprobes? COST TD1402 - RADIOMAG Annual Meeting
COST TD1402 (Lisboa, Portugal)
2015/02/09 pH sensitive liposomes loading prednisolone for the treatment of rheumatoid arthritis. NanoPT 2015
(Porto, Portugal)
2015/02/09 New insights in the development of solid lipid nanoparticles for active brain-targeted drug delivery NanoPT 2015
(Porto, Portugal)
2015/02/09 Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: a multidrug system for theranostics in rheumatoid arthritis NanoPT 2015
(Porto, Portugal)
2014/12/02 Targeted pH sensitive liposomes for the treatment of rheumatoid arthritis Luso-Galego
(Porto, Portugal)
2014/12/02 Solid lipid nanoparticles as a vehicle for brain-targetted drug delivery Luso-Galego
(Porto, Portugal)
2014/11/06 Methotrexate-loaded lipid-based nanoparticles for topical therapy of psoriasis: Optimization and characterization Jornadas Bioengenharia FEUP
(Porto, Portugal)
2014/10/12 A theranostic approach using methotrexate-loaded polymeric nanospheres containing Gold nanoparticles for Rheumatoid Arthritis. Annual Meeting COST ActionTD1004
COST TD1004 (Istambul, Turquia)
2014/06/21 Development of Innovative Therapeutic Approaches for Rare Diseases Training Seminar
(Riga, Letónia)
2013/12/12 Validated chromatographic method for fluorimetric determination of an anti-Leishmania compound in mice tissues 8º Encontro Nacional de Cromatografia
2013/06/06 Crucial CD8+ T-lymphocyte cytotoxic role in amphotericin B nanospheres efficacy against experimental visceral leishmaniasis Infection and Immunity Unit Meeting
IBMC (Porto, Portugal)
2012/11/20 Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis XVI Congresso Português de Parasitologia
(Lisboa, Portugal)
2012/11/20 Drug screening of bisnaphthalimidopropyl derivatives on Trypanosoma brucei XVI Congresso Português de Parasitologia
(Lisboa, Portugal)
2012/09/14 The role of bisnaphthalimidopropyl derivatives to control trypanosomatid neglected infections COST Annual Meeting
COST CM801 (Chania, Grécia)
2012/05/16 Avaliação da atividade in vitro e in vivo do BNIPDaoct encapsulado em nanopartículas poliméricas no parasita Leishmania infantum Jornadas de Parasitologia II, Escola Superior de Tecnologia da Saúde do Porto
Escola Superior de Tecnologia da Saúde do Porto (Vila Nova de Gaia, Portugal)
2011/11/14 In vitro evaluation of BNIPDaoct encapsulated on polymeric nanoparticles on Leishmania infantum parasite VI Congresso Científico da Associação de Estudantes da Faculdade de Farmácia da Universidade do Porto
Associação de Estudantes da Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2011/10/06 Improvement of in vitro and in vivo antileishmanial activities of Bisnaphthalimidopropyldiaaminooctane by encapsulation in poly(D,L-lactide-co-glycolide nanoparticles III Congress of the Portuguese Society of Pharmaceutical Sciences and IX Spanish-Portuguese Conference on Controlled Drug Delivery
(Porto, Portugal)
2011/03/13 The use of poly(lactic-co-glycolic acid) nanoparticles to encapsulate amphotericin B towards visceral leishmaniasis 12th Drug Design and Development
(Heidelberg, Alemanha)
2011/01/10 Nanotechnology as a tool towards trypanosomatids and pancreatic cancer chemotherapies Invited Seminar
University of Vigo (Vigo, Espanha)
2010/09/20 Development of new therapeutics based on the identification of molecular drug targets and on drug screening against the mammalian stage of the parasite. 3rd Scientific Division Day of the Infection and Immunity Unit
IBMC (Porto, Portugal)
2010/05/16 Nanotechnology as a tool towards trypanosomiasis and leishmaniasis chemotherapies 2nd Joint Expert Meeting among Working Groups 1/2/3/4 and MC Meeting of the COST Action CM0801
COST Action CM0801 (Siena, Itália)
2009/05/10 Effect of bisnaphthalimidopropyl polyamine derivatives against experimental Leishmania infantum infection by cytosolic SIR2 related protein 1 Joint Expert Meeting between Working Groups 1 and 3 of the COST Action CM0801
COST Action CM0801 (Sófia, Bulgária)
2001/07/19 Degradation of p-chlorophenol and p-nitrophenol by a microalgae community 10th European Congress in Biotechnology
(Madrid, Espanha)
1998/07/15 Characterisation of bacterial isolates from Serra da Estrela Cheese via analysis of their electrophorectic protein profiles BIOTEC'98
(Guimarães, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2021/10/01 - Atual Design of a hyaluronic acid delivery system to slow down skin ageing
Coorientador
Doctoral Program in Pharmaceutical Sciences (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal

REQUIMTE LAQV Porto, Portugal
2021/05/01 - Atual Tackling microbial resistance: transdermal delivery of antibiotic drugs as Ionic Liquids and Organic Salts using nanostructured biomaterials
Coorientador
Programa Doutoral em Química Sustentável (Doutoramento)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/10 - Atual Natural hydrogels as an Intracanal Therapeutic Tool - combination of antimicrobial and photodynamic therapies to prevent reinfections
Orientador de Sónia Ferreira
Programa Doutoral Ciências Biológicas Aplicadas à Saúde (Doutoramento)
Instituto Universitário de Ciências da Saúde, Portugal
2020/10 - Atual Development and evaluation of berberine nanoparticles as an antimicrobial tool in endodontic irrigation
Orientador de Célia Marques
Programa Doutoral Ciências Biológicas Aplicadas à Saúde (Doutoramento)
Instituto Universitário de Ciências da Saúde, Portugal
2020/02/10 - Atual Controlled modulation of macrophages by sugar-functionalized nanoparticles.
Coorientador de Mariana Romanholo
Mestrado em Ciências Farmacêuticas (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/01/01 - Atual Marine-based nanotechnological approaches for dermatitis in developing countries
Coorientador de Ana Isabel Barbosa
Programa Doutoral BiotechHealth (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/01/02 - Atual Improving health and growth in gilthead seabream (Sparus aurata) through fortified nutrition: discovering new nutraceuticals from marine bio-refineries
Coorientador de Bruno Reis
Programa Doutoral SANFEED (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/10/01 - 2023/09/30 Novel functional ingredients in pet food - a multifactorial study of alternative diets for dogs
Coorientador
Programa Doutoral SANFEED (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/03/01 - 2021/10/07 Alginate-derived microneedle devices for transdermal delivery of rivastigmine - application in skin mimetic model
Coorientador
Mestrado Integrado em Bioegenharia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/03/01 - 2021/09/22 Synthesis of sugar-coated marine polymeric nanosystems for topical delivery of bioactive agents
Orientador de Filipa Serrasqueiro
Mestrado em Química Farmacêutica (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/10/02 - 2021/03/29 Optimization of topical delivery of niacinamide using hydrogels and transethosomes for anti-ageing
Orientador
Mestrado Integrado em Bioengenharia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/02/02 - 2019/09/02 Development and Characterization of Lipid Nanoparticles for Topical Drug Administration
Coorientador de Simone Stefani
Chemistry and Pharmaceutical Technology Master (Mestrado)
Università degli Studi di Modena e Reggio Emilia Biblioteca Universitaria Umanistica, Itália
2019/02/14 - 2019/07/17 Application of gold nanoparticles in fingermarks detection – optimization of detection process
Orientador de Bruna Faria
Licenciatura em Ciências Laboratoriais Forenses (Licenciatura/Bacharelato)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018/03/10 - 2018/07/26 Development of gold nanoparticles in fingermarks detection
Orientador de Application of gold nanoparticles in fingermarks detection
Licenciatura em Ciências Laboratoriais Forenses (Licenciatura/Bacharelato)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2017/09/02 - 2018/07/20 Lipid-based nanocarriers for food applications: strategies to maximize bioactive compounds’ bioavailability and their safety evaluation
Coorientador de Daniela Resende
Bioeengenharia (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2017/09/06 - 2018/02/26 Cyclosporine A-loaded solid lipid nanoparticles for topical application
Orientador de Maria Inês Silva
Mestrado Integrado em Ciências Farmacêuticas (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/12/01 - 2017/12/31 Hidrogéis híbridos - desenvolvimento de uma terapia tópica para a psoríase
Coorientador de Mafalda Patrício
Programa Doutoral em Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2016/10/02 - 2017/11/06 In vitro skin models as a tool in the optimization of drug formulation
Orientador de Zinaida Shakel
Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2016/09/10 - 2017/07/20 Delivery of methotrexate using fucoidan/chitosan pH sensitive nanoparticles
Coorientador de Ana Isabel Ferreira Barbosa
Química Farmacêutica (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2014/10/10 - 2015/07/16 NLC keratinocytes’ uptake mechanism
Orientador de Elisabete Silva
Anatomo-pathology Technologist (Licenciatura/Bacharelato)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2014/09/04 - 2015/07/14 Nanostructured Lipid Carriers: a new approach for Psoriasis dermal therapy
Orientador de Mara Ferreira
Biomedical Engineering Master (Mestrado)
2014 - 2014 Application of lipid nanoparticles for the delivery of methotrexate for dermal treatment of psoriasis
Orientador de Maria Filipa Sanches Pinto
Bioengenharia (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2011/09/14 - 2013/11/26 Study of the Erlotinib (Tarceva) anticancer activity on liposomes
Coorientador de Rita Vidal
Mestrado em Tecnologia Farmacêutica (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2013/02/08 - 2013/07/10 Drug screening in Leishmania promastigotes
Coorientador de Melissa Raboni
Mestrado integrado em Ciências Farmacêuticas (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Farmácia, Portugal
2011/10/02 - 2012/11/29 Drug screening of the bisnaphthilimidopropil derivatives on Trypanosoma brucei
Orientador de Patrícia Varela Martins
Cellular Biology and Biotechnology (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2011/09/15 - 2012/10/26 Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis
Orientador de Daniela Barros
Biochemistry (Mestrado)
2012/02/07 - 2012/09/18 Drug target identification in Leishmania
Orientador de Sónia Nogueira
Mestrado Integrado em Ciências Farmacêuticas (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Farmácia, Portugal
2010/10/10 - 2011/06/08 Development and characterisation of paromomycin nanoparticles towards cutaneous leishmaniasis
Orientador de Raquel Carneiro
Licenciatura em Biologia (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2009/09/12 - 2010/06/04 Development and characterisation of bisnaphthalimidopropyl polyamine derivatives nanoparticles towards Leishmania infantum protozoa
Coorientador de Susana Sampaio
Biology (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2008/09/15 - 2010/01/07 Nanoparticles as drug delivery systems towards leishmaniasis: the effect of PEGylation
Coorientador de Vasco Rodrigues
Biochemistry (Mestrado)
2007/10/01 - 2008/07/25 Characterization and optimization of poly(D,L-lactide-co-glycolide nanoparticles against Leishmania
Coorientador de João Pedro Silva
Biochemistry (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2007/10/02 - 2008/06/25 Development and characterization of poly-lactic acid nanoparticles towards Leishmania protozoa
Coorientador de João Barbosa
Biochemistry (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2002/09/14 - 2003/06/22 Drug partition determination in DMPC and DMPG liposomes
Coorientador de Susana Silva
Chemistry (Outra)
Universidade do Porto Faculdade de Ciências, Portugal
2001/09/20 - 2002/06/20 Aromatic compounds degradation by Chlorella vulgaris
Coorientador de Maria João Saraiva
Microbiology (Licenciatura/Bacharelato)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2001/09/20 - 2002/06/20 Aromatic compounds degradation by Chlorella vulgaris
Coorientador de Mónica Silva
Microbiology (Licenciatura/Bacharelato)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2019 - Atual Universidade Júnior, program of Porto University in the project: À descoberta da nanotecnologia: aplicações na saúde e na alimentação (2019/07) Universidade do Porto, Portugal
2017 - Atual Universidade Júnior, program of Porto University in the project: À descoberta da nanotecnologia: aplicações na saúde e na alimentação (2017)
2011 - Atual Workshop on New antiparasitic and anticancer drugs, funded by the ERA-NET New Indigo network (2011)
Oficina (workshop) (Membro da Comissão Organizadora)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2022/01/17 - 2022/01/21 Winter School on Membrane Biophysics: Impact of Lipids on Health, Disease and Therapy (3rd edition) (2022/01/17)
Oficina (workshop) (Coorganizador)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/06/12 - 2019/06/14 Advanced course on "Protein-ligand interactions: From theory to practice" (2019)
Outro (Membro da Comissão Organizadora)
Universidade do Porto Faculdade de Farmácia, Portugal
2019/05/21 - 2019/05/24 Advanced course in "In vitro models of biological barriers for Health Sciences Applications" (2019)
Outro (Membro da Comissão Organizadora)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/07/02 - 2018/07/13 Universidade Júnior, program of Porto University in the project: À descoberta da nanotecnologia: aplicações na saúde e na alimentação (2018/07/02 - 2018/07/13)
Oficina (workshop) (Presidente da Comissão Organizadora)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/06/25 - 2018/06/29 Summer School on Membrane Biophysics: Impact of Lipids on Health, Disease and Therapy (2nd edition) (2018/06/25)
Oficina (workshop) (Membro da Comissão Organizadora)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/07/24 - 2017/07/28 Summer school on Membrane Biophysics: Impact of Lipids on Health, Disease and Therapy (2017/07/24)
Oficina (workshop) (Membro da Comissão Organizadora)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1998 - 1998 Jornadas de Microbiologia (1998)
Simpósio (Membro da Comissão Organizadora)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2022/02/24 Pharmaceutical Ionic Liquids as an Effective Treatment against Mycobacterium Tuberculosis
Arguente principal
Hugo Araújo (Mestrado)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/01/27 Optimization of nanoparticles for the release of icilin in rheumatic diseases
Arguente principal
Diana Sousa (Mestrado)
Universidade do Minho Centro de Engenharia Biológica, Portugal
2021/02 Fabrication of a Yeast Microcapsule Platform for Bone Tissue Regeneration
Arguente principal
Patrícia Gaspar de Oliveira (Mestrado)
Universidade de Aveiro Departamento de Engenharia de Materiais e Cerâmica, Portugal
2020/11/12 After the antibiotic era: effect of Nanostructured Lipid Carriers against Helicobacter pylori biofilms
Arguente principal
Ana Sofia Ferreira Leite de Pinho (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/05/11 Lipid nanoparticles biocompatibility and cellular uptake in a 3D human lung model
Arguente principal
Marina Barroso Pereira Pinheiro (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2020 Development of Neurotherapeutic Polyplexes for Oxidative Stress in Ischemic Stroke
Arguente principal
Joana Filipa Ferreira Moreira (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/07/11 Bioengineering a 3D heterotypic tumor model to study the dynamics of endothelial cells recruitment and growth
Arguente principal
Sara Chaves (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/10/15 Establishment of tricultures in microfluidic platforms
Arguente principal
Miguel Guilherme Linhas Simões (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/07/20 Lipid-based nanocarriers for food applications: strategies to maximize bioactive compounds’ bioavailability and their safety evaluation
Orientador
Daniela Resende (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2017/11/06 In vitro skin models as a tool in the optimization of drug formulation
Orientador
Zinaida Shakel (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2017/10/12 Polymeric-based nanoparticles targeting the CCR5 co-receptor as an innovative approach for the delivery of antiretroviral compounds
Arguente principal
Catarina Coutinho (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/10/12 Trimethyl-Chitosan-based Polyplexes for Neurotrophin Mimicking in Brain Ischaemia
Arguente principal
Simão Pedro Barbosa Teixeira (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/07/21 Delivery of methotrexate using Fucoidan/Chitosan pH sensitive nanoparticles
Orientador
Ana Isabel Barbosa (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/07/05 Nanostructured lipid carriers as a promising drug delivery system for streptomycin
Arguente
Sara Pinheiro (Outro)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/06/02 New Technologies technologies for the improvement of leprosy multidrug therapy: a quality by design approach
Vogal
Luíse Lopes Chaves (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2016/11/13 Antiparasitic potential of natural marine compounds
Arguente principal
Gisela Almeida Castro (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2015/12/11 Protein-based nanodevices for therapeutic applications
Arguente principal
Ana Isabel Loureiro (Doutoramento)
Universidade do Minho Escola de Ciências, Portugal
2015/10/06 Nanoparticle Delivery System for Bone Regeneration
Arguente principal
Joana Nave (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2015/07/14 Nanostructured Lipid Carriers: a new approach for Psoriasis dermal therapy
Orientador
Mara Ferreira (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2014/12/27 MicroRNA modulation incombination with chemotherapeutic drugs as a novel therapeutic strategy for pancreatic cancer
Arguente principal
Marta Daniela Passadouro Caetano (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/07/15 Development of multifunctional nanoparticles for targeted therapy and imaging of rheumatoid arthritis
Arguente principal
Catarina Moura (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2012/11/29 Drug screening of the bisnaphthilimidopropil derivatives on Trypanosoma brucei
Orientador
Patrícia Varela Martins (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/10/26 Mannosylated nanoparticles for targeted delivery of amphotericin B towards visceral leishmaniasis
Orientador
Daniela Barros (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2010/05/12 Leishmania spp infection model optimization for drug discovery purposes
Arguente principal
Maria Helena Azevedo Teixeira de Andrade (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2010/01/07 Nanoparticles as drug delivery systems towards leishmaniasis: the effect of PEGylation
Orientador
Vasco Rodrigues (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018/10/25 - Atual Immunotherapy International
2018/06/02 - Atual Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (0304-419X) Elsevier
2018/04/02 - Atual ACS Applied Materials & Interfaces
2018/02/04 - Atual Journal of Pharmaceutics (2090-7818) Hindawi (International Scholarly Research Network)
2017/04/10 - Atual Polymers (2073-4360) MDPI AG
2017/03/20 - Atual Nanomaterials and Nanotechnology (1847-9804) SAGE Publications
2017/03/12 - Atual Journal of Advanced Research (2090-1232) Elsevier
2017/03/02 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2017/02/02 - Atual Molecules (1420-3049) MDPI AG
2017/01/29 - Atual Journal of the Science of Food and Agriculture (1097-0010) Wiley (John Wiley & Sons)
2016/06/03 - Atual Current Drug Delivery (1567-2018) Bentham Science
2016/05/02 - Atual Chemistry and Physics of Lipids (0009-3084) Elsevier
2016/04/10 - Atual Journal of Liposome Research (1532-2394) Informa UK (Taylor & Francis)
2016/04/10 - Atual Nanomaterials (2079-4991) MDPI AG
2016/03/10 - Atual Journal of Clinical Dermatology & Therapy
2016/03/05 - Atual ACS Biomaterials Science & Engineering (2373-9878) American Chemical Society
2015/04/02 - Atual Drug Development and Industrial Pharmacy (1520-5762) Informa UK (Taylor & Francis)
2015/02/10 - Atual Acta Biomaterialia (1742-7061) Elsevier
2015/02/10 - Atual Nanomedicine (1748-6963) Future Medicine
2014/09/04 - Atual Biomaterials (0142-9612) Elsevier
2013/04/10 - Atual International Journal of Nanomedicine (1178-2013) Dove Medical Press
2011/04/14 - Atual Parasitology International (1383-5769) Elsevier
2010/02/10 - Atual Colloids and Surfaces B Biointerfaces (0927-7765) Elsevier

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2021/07/01 - Atual Member of the evaluation panel of doctoral projects presented by 1st year students of the Doctoral Program BiotechHealth. Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/03 - Atual Grant Reviewer
Avaliador
National Science Centre Poland , Polónia
2019/07/01 - Atual Member of the evaluation panel of doctoral projects presented by 1st year students of the Doctoral Program BiotechHealth. Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - Atual Grant Reviewer
Avaliador
Graduated Women in Science, Estados Unidos
2019 - Atual Grant Reviewer
Avaliador
The Israel Science Foundation, Israel
2017 - Atual Grant Reviewer
Avaliador
Université de Bordeaux, França
2014 - Atual Evaluator of Trans-Domain COST Action Proposal Call
Avaliador
European Commission, Bélgica European Cooperation in Science and Technology
2010/02/01 - Atual Member of the panel on the Pluridisciplinar projects 2010 of Porto University
Avaliador
Universidade do Porto, Portugal Banco Santander Totta
2017/05/20 - 2018/03/05 Grant Reviewer for European Commission H2020 projects
Avaliador
European Commission, Bélgica European Commission

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/05/12 - Atual Nanostrategies for skin delivery: application of in vitro models for drug absorption  Advanced Course “Bionanoparticles: challenges and therapeutic opportunities” (Outros) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2019/06/19 - Atual Standard operating procedures (SOPs): theory Advanced course on Protein-ligand interactions: From theory to practice (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2019/06/19 - Atual Experimental protocols and standard operating procedures: practice Advanced course on Protein-ligand interactions: From theory to practice (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2019/06/18 - Atual Hands-on training: Ligand binding immunoassays Advanced course on Protein-ligand interactions: From theory to practice (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2019/06/17 - Atual Ligand binding immunoassays: theory Advanced course on Protein-ligand interactions: From theory to practice (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2019/05/29 - Atual Nanomedicine-based strategies to beat cancer Cancer therapy: from basic research to clinic (Pós-Graduação) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2019/05/24 - Atual Hands-on training: Franz diffusion cells Advanced course on In vitro models of biological barriers for Health Sciences Applications (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2019/05/23 - Atual Skin: practical aspects Advanced course on In vitro models of biological barriers for Health Sciences Applications (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2016/06/02 - Atual Multifunctional nanoparticles for cancer magnetic hyperthermia therapy Advanced course on Bionanoparticles: challenges and therapeutic opportunities (Pós-Graduação) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2014/05/28 - Atual Multifunctional nanomedicine platforms for Cancer Therapeutics Bionanotechnology for diagnosis and therapy of cancer (Pós-Graduação) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2021/09/15 - 2022/02/14 Laboratório Forense II Ciências Laboratoriais Forenses (Licenciatura) Instituto Universitário de Ciências da Saúde, Portugal
2020/09/15 - 2021/02/14 Laboratório Forense II Ciências Laboratoriais Forenses Instituto Universitário de Ciências da Saúde, Portugal
2019/09/20 - 2020/02/08 Laboratorio Forense II Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2018/09/17 - 2019/02/10 Laboratório Forense II Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2017/09/20 - 2018/02/10 Laboratório Forense II Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2016/10/02 - 2017/02/12 Laboratório Forense II Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2015/10/06 - 2016/02/10 Laboratório Forense II Ciências Laboratoriais Forenses (Licenciatura) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2000 - 2001 Microbiologia Geral I Microbiologia (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2000 - 2001 Microbiologia Geral II Microbiologia (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2000 - 2001 Microbiologia Geral II Engenharia Alimentar (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2000 - 2001 Tecnologias e Tratamento de Efluentes II Engenharia do Ambiente (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
1999 - 2000 Microbiologia do Ambiente Microbiologia (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2020/07/12 Researchers from Porto take advantage of the qualities of nanoparticles to combat COVID-19 Porto News
2020/07/04 nano2Prevent project: Nanoparticles to kill the virus on the protection individual equipments in the hospital and nursing home Diário de Notícias
2020/07/01 Portuguese researchers fight viruses with nanotechnology Portugal Textil
2020/06/30 Portuguese laboratory wants to combat Covid-19 by incorporating nanoparticles in textiles Sapo24

Expedição científica

Descrição da atividade Instituição / Organização
2021/11/01 - 2021/11/06 Short scientific mission to perform measurements using synchrotron-based infrared microspectroscopy at Alba Synchrotron. Barcelona, Spain. Centro Universitario Internacional de Barcelona, Espanha
2017/10/22 - 2017/11/26 Short scientific mission to perform measurement using synchrotron-based infrared microspectroscopy at Alba Synchrotron. Barcelona, Spain. Centro Universitario Internacional de Barcelona, Espanha

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2020 - Atual Editorial Board Member of the journal Marine Drugs, is the leading, peer-reviewed, open access journal on the research, development, and production of biologically and therapeutically active compounds from the sea. IF 5.1 Journal Rank: JCR - Q1 (Chemistry, Medicinal) / CiteScore - Q1 (Pharmacology, Toxicology and Pharmaceutics, miscellaneous) https://www.mdpi.com/journal/marinedrugs
Outro
2019/10 - Atual Supervisor Member of the International Doctoral Programme in Molecular and Cellular Biotechnology Applied to Health Sciences
Membro
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

REQUIMTE LAQV Porto, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - Atual Editorial Board Member of the journal Chemistry, peer-reviewed, open access journal on the chemistry, indexed within Scopus, ESCI (Web of Science), CAPlus / SciFinder, and many other databases. https://www.mdpi.com/journal/chemistry
Outro
2017 - Atual Supervisor Member of the International Doctoral Programme in Sustainable Animal Nutrition and Feeding
Membro
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

REQUIMTE LAQV Porto, Portugal

Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2018/06 - 2022 CA16205: European Network on Understanding Gastrointestinal Absorption-related Processes (UNGAP) as management committee substitute and working group member. https://gbiomed.kuleuven.be/english/research/50000715/50000716/ungap
Membro
European Cooperation in Science and Technology, Bélgica
2014 - 2018 TD1402 "Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (RADIOMAG)" as management committee, group leader and working group member http://www.cost-radiomag.eu/
Membro
European Cooperation in Science and Technology, Bélgica
2014 - 2018 CM1307 "Targeted chemotherapy towards diseases caused by endoparasites" as Management committee substitute and working group member.
Membro
European Cooperation in Science and Technology, Bélgica
2015/05/13 - 2015/05/15 Evaluation of research works presented as poster communication in the field of Chemistry at IJUP
Membro
Universidade do Porto, Portugal
2012 - 2014 TD1004 "Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery" as working group member
Membro
European Cooperation in Science and Technology, Bélgica
2013/02/13 - 2013/02/15 Evaluation of research works presented as poster communication in the field of Chemistry at IJUP
Membro
Universidade do Porto, Portugal
2012/02/22 - 2012/02/24 Evaluation of research works presented as poster communication in the field of Chemistry at IJUP
Membro
Universidade do Porto, Portugal
2011/11/21 - 2011/11/25 Evaluator of poster communications presented in the 11th edition of the Trends in Nanotechnology International Conference (TNT2010)
Membro
2011/02/17 - 2011/02/19 Evaluation of research works presented as poster communication in the field of Chemistry at IJUP
Membro
Universidade do Porto, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2021/07/31 - Atual Jury member in a public tender for a research fellowship for a graduated student in the scope of the Project HEALTH-UNORTE: Setting-up Biobanks And Regenerative Medicine Strategies to Boost Research in Neurosciences, Immunology and Infection, Musculoskeletal, Cardiovascular and Oncologic Diseases (refª NORTE-01-0145-FEDER-000039) Universidade do Porto Faculdade de Farmácia, Portugal
2021/01/02 - Atual Jury member in a public tender for Master's Research fellowship (Ref. REQUIMTE 2020-29), under the project PTDC/QUI-COL/30834/2017, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
2020/01 - Atual Jury member in a public tender for Master's Research fellowship (Ref. REQUIMTE 2020-04), under the project PTDC/QUI-COL/30834/2017, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal
2019/11 - Atual Jury member in a public tender for Master's Research fellowship (Ref. ICETA 2019-76), under the project PTDC/QUI-COL/30834/2017, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal
2019/09 - Atual Jury member in a public tender for a Research fellowship (Reference ICETA 2019-76) at the Associated Laboratory for Green Chemistry financed by National Funds through FCT / MCTES and considering the UID's Pluriannual funding UID/QUI/50006/2019 (2020-2023). Universidade do Porto Faculdade de Farmácia, Portugal
2019/03 - Atual Jury member in a public tender for Master's Research fellowship (Ref. ICETA 2019-23), under the project PTDC/QUI-COL/30834/2017, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal
2019/03 - Atual Jury member in a public tender for an Assistant Researcher contract (REQUIMTE 2018-46), within the framework of a project, PTDC/QUI-COL/30834/2017, financed by national funds through FCT / MCTES and the FEDER, through the COMPETE-Operational Competitiveness Factors Program (POFC) POCI-01-0145-FEDER-030834.
2018 - Atual Jury member in a public tender for an Master's Research fellowship, within the framework of a project, PTDC/MAR-BIO/4694/2014, financed by national funds through FCT / MCTES and the FEDER, through the COMPETE-Operational Competitiveness Factors Program (POFC) POCI-01-0145-FEDER-016790.
2017/10 - Atual Jury member in a public tender for a Research fellowship (Ref. ICETA 2017-34), under the project PTDC/MAR-BIO/4694/2014, with the financial support of FCT/MCTES through national funds and when applicable co-financed by the FEDER under the Partnership Agreement COMPETE 2020 Universidade do Porto Faculdade de Farmácia, Portugal

Tutoria

Tópico Nome do aluno
2021/09/01 - 2021/09/30 Entrega Transdérmica de fármacos usando biomateriais naturais no controlo da inflamação Ana Catarina dos Santos Dias
2021/04 - 2021/08 Design of advanced resveratrol transdermal delivery systems: Evaluation of drugs permeation in skin mimetic models Alexandra Mujica
2020/02/12 - 2020/07/31 Alginate as base polymer for hydrogels loaded with quercetin Ludovico Esposito
2018/02/02 - 2019/11/30 Thymoquinone-loaded nanostructured lipid carrier: physicochemical characterization and interactions with a breast cancer cell line Ong Yong Sze
2019/07/02 - 2019/09/28 Evaluation of skin permeability of bioactive compounds Sedef Kaplan
2019/02/10 - 2019/07/02 Nanoemulsions of fractions rich in pomegranate polyphenols and their protective effect against fluoride poisoning Kaoutar Chattahy
2018/04/02 - 2018/07/29 Pomegranate seeds applied to nanotechnology Talal Sabraoui
2017/09/05 - 2018/06/30 Development of pH-responsive fucoidan/chitosan nanoparticles Joana Filipa Cardoso
2016/09/02 - 2017/06/28 Controlled release of active ingredients by matrices Abderrazzaq Essaghraoui
2015/09/03 - 2016/02/29 PLGA-Au nanospheres characterisation and validation in rheumatoid arthritis Paola Tibalo
2010/09/15 - 2011/06/15 Development of a resistant strain of L. infantum to BNIPDaoct Sónia Nogueira
2010/02/10 - 2010/10/20 Evaluation of the in vitro biological effects of novel bisnaphthalimidopropyl polyamine derivatives in Leishmania infantumv Tariq Hassam
2009/09/04 - 2010/06/20 Optimisation and characterisation of nanoparticles targeted to macrophages Joana Oliveira
2008/09/10 - 2009/06/13 Evaluation of the in vitro released compounds from polymeric nanoparticles Joana Soares
Distinções

Prémio

2021 Best oral presentation ESB 2021
2020 Best Poster presentation award
2019 Best Oral Communication in Chemistry
Universidade do Porto, Portugal
2018 Best Oral Communication in Chemistry
2018 Best Poster Communication in Chemistry
2016 Best Poster, 11th Inorganic Chemistry Conference, Sintra, Portugal

Outra distinção

2008 Postdoctoral fellowship (BPD/37880/2007)
Fundação para a Ciência e a Tecnologia, Portugal
2001 PhD fellowship (PRAXIS XXI BD/4613/2001)
Fundação para a Ciência e a Tecnologia, Portugal
1998 MSc fellowship (PRAXIS XXI BM/20357/98)
Fundação para a Ciência e a Tecnologia, Portugal