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Tiago Costa-Coelho is a Neuroscience PhD student at Instituto de Farmacologia e Neurociências and Instituto de Medicina Molecular João Lobo Antunes, both belonging to the Faculty of Medicine, University of Lisbon and at the Research Institute for Medicines, Faculty of Pharmacy, University of Lisbon. Ever since middle school, Tiago has been highly motivated to build a path in Neuroscience, helping in the discovery of our brains' unknown mechanisms, taking particular interest in neurodegeneration. To that endeavour, he joined Sandra Tenreiro at the Cell and Molecular Neuroscience Lab (Tiago Outeiro's Group) to study human alpha-synuclein in Parkinson’s disease. Currently he integrates the team of Maria José Diógenes at the Neuronal Communication and Synaptopathies Lab (Ana Sebastião Group) at FMUL/iMM and the team of Dora Brites at the Neuroinflammation, Signaling and Neuroregeneration Lab (Dora Brites Group) at iMed.ULisboa. His research interests' dwell in studying BDNF signaling dysregulation through extracellular vesicles in Alzheimer’s disease. Notwithstanding, his background in biochemistry enables him in understanding a variety of chemistry/biology-related fields and biomedical research areas. Regarding his personality, he considers himself as an extremely easy-going person as well as a quick thinker and learner.
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Identification

Personal identification

Full name
Tiago Rodrigo da Costa Coelho

Citation names

  • Costa-Coelho, Tiago

Author identifiers

Ciência ID
7119-01F6-7187
ORCID iD
0000-0003-3097-6728
Google Scholar ID
-XgnSEQAAAAJ&hl

Email addresses

  • tcoelho@medicina.ulisboa.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2023/04 - 2023/04
Concluded
 Proteomics Approaches in Life Sciences - CNC Advanced Courses 2023 (Doctoral Program in Experimental Biology and Biomedicine) (Pós-Graduação)
Universidade de Coimbra, Portugal
 15
2021/11 - 2021/11
Concluded
 CONGENTO Practical Course on Laboratory Animal Science (Function A and D) (Outros)
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 18
2021/11 - 2021/11
Concluded
 CONGENTO Theoretical Course on Laboratory Animal Science (Function A, C and D) (Outros)
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 18
2018 - 2021
Concluded
 Biochemistry for Health (Mestrado)
Major in Biochemistry for Health
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
"Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome signalling in Alzheimer’s disease" (THESIS/DISSERTATION)
 19
2015 - 2018
Concluded
 Biochemistry (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Dissecting the mechanisms underlying mutant alpha-synuclein toxicity in Parkinson's disease" (THESIS/DISSERTATION)
 16
2015
Concluded
 Sciences and Technology (Ensino secundário)
Escola Secundária Daniel Sampaio, Portugal
 17
Affiliation

Science

Category
Host institution 		Employer
2022/01 - Current Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2021/08 - 2022/12 Researcher (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019/07 - 2021/07 Research Trainee (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/01 - 2018/08 Research Trainee (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/02 - 2017/06 Research Trainee (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Projects

Grant

Designation Funders
2023/01 - 2025/12 Novel treatment and early diagnostics of AD
PhD Student Fellow
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 PRR: Pacto de Inovação "HfPT - Health from Portugal"
Ongoing
2024 - 2025 TrkB-ICD as a diagnostic companion for a novel class of promising compounds in Alzheimer´s disease
ongoing
PhD Student Fellow
Universidade de Lisboa Faculdade de Medicina, Portugal
 AstraZeneca Produtos Farmacêuticos Lda
Ongoing
2022 - 2025 TAT-TrkB, a novel neuroprotective compound to fight Alzheimer's disease
Researcher
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Santa Casa da Misericórdia de Lisboa
Ongoing
2020 - 2021 Monitorização terapêutica do TAT-TrkB na prevenção da clivagem do recetor do BDNF (TrkB-FL) no líquido cefalorraquidiano e sangue de modelo animal
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Universidade de Lisboa Faculdade de Medicina
Concluded
Outputs

Publications

Conference poster
  1. Ferreira-Manso, Mafalda; Costa-Coelho, Tiago; Inteiro-Oliveira, Sara; Neuparth-Sottomayor, Mariana; Sebastião, Ana M.; Diógenes, Maria José. "TAT-TrkB peptide administration in vivo prevents hippocampal long-term potentiation deficits in 5xFAD mice". Paper presented in 37ª Reunião Anual Grupo de Estudos de Envelhecimento Cerebral e Demência, Lisboa, 2024.
  2. Inteiro-Oliveira, Sara; Marta-Fernandes, Lia; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "A virtual-aided design of small compounds to prevent BDNF receptor cleavage in Alzheimer’s disease". Paper presented in EPHAR2024, 2024.
  3. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori, Juzoh; et al. "Loss of Neuroprotection in Alzheimer’s disease: Shedding Light on BDNF Receptor Cleavage And Its Mirroring In Extracellular Vesicles". Paper presented in FENS Forum 2024, 2024.
  4. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori, Juzoh; et al. "Mirroring of BDNF/TrkB Dysregulation On Brain Parenchyma and Plasma-derived Extracellular Vesicles from Alzheimer’s disease Patients". Paper presented in EpiC24, 2024.
  5. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori, Juzoh; et al. "BDNF/TrkB system dysregulation at the cell environment: extracellular vesicles as carriers of TrkB-ICD in Alzheimer’s disease". Paper presented in ISEV2024, 2024.
  6. Lourenço, M; Miguéis, M; Ianni, Marta; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Nuno Aleman-Serrano; et al. "Exploring miR-124 Key Role in the Interplay Between Autophagy and NLRP3 in the 5xFAD Mice". Paper presented in VIII Symposium of the Portuguese Glial Network, 2024.
  7. Inteiro-Oliveira, Sara; Barreira-Fernandes, Lia; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Small Compounds: a promising strategy to prevent TrkB-FL cleavage in Alzheimers Disease". Paper presented in EMBO Young Scientists Forum, 2023.
  8. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori, Juzoh; et al. "BDNF receptor dysregulation is mirrored in cerebrospinal fluid and plasma-derived extracellular vesicles from Alzheimer's disease patients". Paper presented in EMBO Young Scientists Forum 2023, 2023.
  9. Ferreira-Manso, Mafalda; Costa-Coelho, Tiago; Inteiro-Oliveira, Sara; Neuparth-Sottomayor, Mariana; Sebastião, Ana M.; Diógenes, Maria José. "TAT-TrkB administration in vivo prevents hippocampal long-term potentiation deficits in 5xFAD mice". Paper presented in EMBO Young Scientists’ Forum, Lisboa, 2023.
  10. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori, Juzoh; et al. "Brain-derived Neurotrophic Factor receptor: cleaved TrkB-FL C-terminal fragment is secreted extracellularly". Paper presented in SNEV Virtual Conference 2023: Everything Everywhere All About Extracellular Vesicles, 2023.
  11. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Umemori, Juzoh; Castrén, Eero; Sebastião, AM; Brites, Dora; Diógenes, MJ. "Extracellular release of a fragment derived from BDNF receptor cleavage". Paper presented in 2nd Meeting of the Portuguese Network of Extracellular Vesicles, 2023.
  12. Inteiro-Oliveira, Sara; Barreira-Fernandes, Lia; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Small Compounds: a new promising strategy to prevent BDNF receptor cleavage". Paper presented in 37ª Reunião Anual Grupo de Estudos de Envelhecimento Cerebral e Demência, 2023.
  13. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, G; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori J; et al. "Shedding light on BDNF/TRKB-FL system dysregulation in Alzheimer's disease". Paper presented in 37ª Reunião Anual do Grupo de Envelhecimento Cerebral e Demência (GEECD), 2023.
  14. Ferreira-Manso, Mafalda; Costa-Coelho, Tiago; Inteiro-Oliveira, Sara; Neuparth-Sottomayor, Mariana; Sebastião, Ana M.; Diógenes, Maria José. "The in vivo administration of the new compound, TAT-TrkB, prevents hippocampal long-term potentiation deficits in 5xFAD mice". Paper presented in FENS Regional Meeting, Salgados Palace hotel, Algarve, 2023.
  15. Inteiro-Oliveira, Sara; Barreira-Fernandes, Lia; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Computational-aided design of small compounds to prevent TrkB-FL receptor cleavage". Paper presented in FENS Regional Meeting 2023, 2023.
  16. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Sebastião, AM; Brites, Dora; Diógenes, MJ. "Dysregulation of the BDNF/TrkB system in Alzheimer's disease ramifies in the secretion of a TrkB-derived fragment through extracellular vesicles". Paper presented in FENS Regional Meeting 2023, 2023.
  17. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Ferreira CB; de Almeida-Borlido, Carolina; Umemori J; et al. "Surveying TrkB-ICD secretion pathways and its presence in cerebrospinal fluid from Alzheimer's disease patients". 2023.
  18. Ferreira-Manso, Mafalda; Fonseca-Gomes, João; Belo, Rita F.; Miranda-Lourenço, Catarina; Costa-Coelho, Tiago; Sebastião, Ana M.; Fernandes, Adelaide; Diógenes, Maria José. "A novel peptide able to recover cognitive impairments and TrkB-FL levels in an Alzheimer’s disease mouse model". Paper presented in 2.º Simpósio sobre a Doença de Alzheimer, Porto, Portugal, 2023.
  19. Nuno Aleman-Serrano; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Diógenes, MJ; Ana Maria Ferreira de Sousa Sebastião. "BDNF receptor dysfunction across dementias: evaluating TrkB-ICD in human AD and FTD patient samples". Paper presented in XXV Conference of Young SIF Pharmacologists Urbino, 2023.
  20. Nuno Aleman-Serrano; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Diógenes, MJ; Ana Maria Ferreira de Sousa Sebastião. "BDNF signaling pathway disfunction across dementias: TrkB-ICD in human AD and FTD patient samples". Paper presented in FENS Regional Meeting, 2023.
  21. Nuno Aleman-Serrano; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Diógenes, MJ; Ana Maria Ferreira de Sousa Sebastião. "BDNF receptor cleavage across dementias: evaluating TrkB-ICD in human AD and FTD samples". Paper presented in 2nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics, 2023.
  22. Nuno Aleman-Serrano; Costa-Coelho, Tiago; Diógenes, MJ; Ana Maria Ferreira de Sousa Sebastião. "BDNF receptor cleavage in Alzheimer´s Disease: From mice to humans". Paper presented in 7.ª Conferência Anual da RedeSAÚDE, 2023.
  23. Inteiro-Oliveira, Sara; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Virtual docking design of small compounds to prevent TrkB-FL receptor cleavage". Paper presented in 3rd Anual Meeting of Epileptogenesis and Epilepsy Network (EpiEpiNET), 2022.
  24. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Brites, Dora; Diógenes, MJ. "Insight on TrkB-FL cleavage as a potential biomarker in Alzheimer’s disease". Paper presented in 3rd Annual Meeting EpiEpiNet, 2022.
  25. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Umemori J; Castrén E; Sebastião, AM; Brites, Dora; Diógenes, MJ. "Dysregulation Of Brain-Derived Neurotrophic Factor Receptor In Alzheimer's Disease Is Mirrored In Extracellular Vesicles". Paper presented in FENS Forum 2022, 2022.
  26. Ferreira-Manso, Mafalda; Fonseca-Gomes, João; Belo, Rita F.; Miranda-Lourenço, Catarina; Costa-Coelho, Tiago; Sebastião, Ana M.; Fernandes, Adelaide; Diógenes, Maria José. "5xFAD mice present memory impairments and reduced TrkB-FL levels that were reverted after TAT-TrkB administration". Paper presented in FENS Forum 2022, 2022.
  27. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Umemori, Juzoh; Castrén, Eero; Sebastião, AM; Brites, Dora; Diógenes, MJ. Corresponding author: Costa-Coelho, Tiago. "TrkB-FL Cleavage Promotes Release of Neuronal TrkB-ICD Within the Secretome of Cholinergic-like Cells in Alzheimer's disease". Paper presented in AIMS2022 Research Competition, 2022.
  28. Inteiro-Oliveira, Sara; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. Corresponding author: Inteiro-Oliveira, Sara. "Computer-aided drug design of small compounds to prevent TrkB-FL receptor cleavage". Paper presented in AIMS2022 Research Competition, 2022.
  29. Aleman Serrano, Nuno; Cardoso-Amaral, Rita; de Almeida-Borlido, Carolina; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Ribeiro-Rodrigues, Leonor; Sebastião, AM; Diógenes, MJ. Corresponding author: Cardoso-Amaral, Rita. "A new key for unlocking Alzheimer's Disease". Paper presented in AIMS2022 Research Competition, 2022.
  30. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Umemori, Juzoh; Castrén, Eero; Sebastião, AM; Brites, Dora; Diógenes, MJ. Corresponding author: Costa-Coelho, Tiago. "SH-SY5Y-derived extracellular vesicles drive the release of a Brain-derived Neurotrophic Factor receptor fragment: relevance for Alzheimer's disease". Paper presented in Epiepinet 2nd Annual Meeting, 2022.
  31. Aleman Serrano, Nuno; Cardoso-Amaral, Rita; de Almeida-Borlido, Carolina; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Ribeiro-Rodrigues, Leonor; sbastião, Ana M; Diógenes, Maria J. "Establishing a new method for TrkB-FL cleavage detection in murine CSF and plasma". Paper presented in 2nd annual meeting Epiepinet, 2022.
  32. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Umemori, Juzoh; Castrén, Eero; Sebastião, AM; Brites, Dora; Diógenes, MJ. Corresponding author: Costa-Coelho, Tiago. "SH-SY5Y-derived extracellular vesicles drive the release of a BDNF receptor fragment: relevance for Alzheimer's disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  33. Aleman Serrano, Nuno; Cardoso-Amaral, Rita; de Almeida-Borlido, Carolina; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Ribeiro-Rodrigues, Leonor; Sebastião, AM; Diógenes, MJ. Corresponding author: Cardoso-Amaral, Rita. "Method optimization to evaluate TrkB-ICD in cerebrospinal fluid and blood of mice". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  34. Ferreira-Manso, Mafalda; Fonseca-Gomes, João; Belo, Rita F.; Miranda-Lourenço, Catarina; Costa-Coelho, Tiago; Sebastião, AM; Fernandes, Adelaide; Diógenes, MJ. Corresponding author: Ferreira-Manso, Mafalda. "TAT-TrkB, a novel peptide able to restore TrkB-FL levels and the learning curve of 5xFAD mice". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  35. Inteiro-Oliveira, Sara; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. Corresponding author: Inteiro-Oliveira, Sara. "Screening of small, non-peptide compounds to prevent TrkB-FL cleavage in Alzheimer's disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  36. Aleman Serrano, Nuno; Cardoso-Amaral, Rita; de Almeida-Borlido, Carolina; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Ribeiro-Rodrigues, Leonor; Sebastião, AM; Diógenes, MJ. Corresponding author: Aleman Serrano, Nuno. "Therapeutic monitorization of TAT-TrkB effect in preventing BDNF (TrkB-FL) receptor cleavage in CSF and blood of animal model". Paper presented in 10ª Edição do Dia de Investigação - Science is Alive, 2021.
  37. Costa-Coelho, Tiago; Fonseca-Gomes, João; Ferreira, Catarina B; Sebastião, AM; Brites, Dora; Diógenes, MJ. "Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome/exosome signalling in Alzheimer's disease". Paper presented in 5th Meeting, Mind-Brain College, 2019.
Journal article
  1. Inteiro-Oliveira, Sara; Ferreira-Manso, Mafalda; Costa-Coelho, Tiago; Nuno Alemãn-Serrano; Ribeiro-Rodrigues, Leonor; Ana Laura Duarte; Viais, Ricardo; et al. "Seizing epilepsy across neurological disorders highlighting BDNF/TrkB signaling and synaptic dysfunction". in preparation (2024):
  2. Ana Salomé Correia; Marília Torrado; Costa-Coelho, Tiago; Eva Carvalho; Inteiro-Oliveira, Sara; Maria J. Diógenes; Ana P. Pêgo; et al. "Brain-derived neurotrophic factor modulation in response to oxidative stress and corticosterone: role of scopolamine and mirtazapine". Life Sciences (2024):
    Under revision
  3. Fonseca-Gomes, João; Rodrigues, Tiago M; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Aleman Serrano, Nuno; Vaz, Sandra H.; et al. Corresponding author: Diógenes, MJ. "A Small TAT-TrkB Peptide Prevents BDNF Receptor Cleavage and Restores Synaptic Physiology in Aß-Induced Dysfunction in Alzheimer’s disease". Molecular Therapy (2024):
    Under revision
  4. Fonseca-Gomes, João; Ribeiro-Rodrigues, Leonor; Mouro, Francisco M.; Paulo SP; Tanqueiro SR; Belo RF ; Miranda-Lourenço, Catarina; et al. Corresponding author: Diógenes, MJ. "TrkB-ICD fragment promotes transcriptomic, proteomic, and synaptic alterations, driving recognition memory impairment in healthy rodents.". in preparation (2024):
  5. Alemãn-Serrano, Nuno; Costa-Coelho, Tiago; Inteiro-Oliveira, Sara; Ferreira-Manso, Mafalda; Sebastião, AM. "The spectrum of cognition: dysfunction of the brain-derived neurotrophic factor signaling across dementias". in preparation (2024):
  6. Miranda-Lourenço, Catarina; Ribeiro-Rodrigues, Leonor; Fonseca-Gomes, João; Tanqueiro, Sara R.; Belo, Rita F.; Ferreira, Catarina B.; Rei, Nádia; et al. "Challenges of BDNF-based therapies: From common to rare diseases". Pharmacological Research 162 (2020): 105281. http://dx.doi.org/10.1016/j.phrs.2020.105281.
    Published • 10.1016/j.phrs.2020.105281
  7. Belo, Rita F.; Martins, Margarida L. F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, Vera; et al. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid ß Peptide-Induced Alzheimer’s Disease Pathophysiology". Frontiers in Pharmacology 11 (2020): http://dx.doi.org/10.3389/fphar.2020.00985.
    Published • 10.3389/fphar.2020.00985
Thesis / Dissertation
  1. "Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome signalling in Alzheimer's disease". Master, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2021.
  2. "Dissecting the mechanisms underlying mutant alpha-synuclein toxicity in Parkinson's disease". Degree, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2018.

Artistic / Performance

Visual artwork
  1. Costa-Coelho, Tiago. Art of Neuroscience 2022: Community.
  2. Costa-Coelho, Tiago. Art of Neuroscience 2021: Homeostasis of Thought.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/03/14 Secretome mirroring of BDNF/TrkB dysregulation in Alzheimer's disease Portuguese Society of Neurosciences (SPN) Seminar Series
2024/02/07 Restore Synaptic And Cognitive Function In An Alzheimer’s Disease Mice Model By Avoiding BDNF Loss Of Function 54ª Reunião da Sociedade Portuguesa de Farmacologia
Faculdade de Ciências Médicas da Universidade NOVA de Lisboa
2023/11/14 BDNF as a beacon of trophic support: Extracellular vesicles mirror BDNF-TrkB dysfunction in Alzheimer’s disease Pizza Seminar PhD Series - Instituto de Medicina Molecular João Lobo Antunes
2023/11/07 Human Temporal Lobe and Cerebrospinal Fluid Samples Mirror the Dysregulation Signature of the BDNF/TrkB System in Alzheimer’s disease Workshop on Biochemistry of Ageing
Sociedade Portuguesa de Bioquímica
2023/06/22 Extracellular release of a fragment derived from BDNF receptor cleavage 2nd Meeting of the Portuguese Network of Extracellular Vesicles
Faculdade de Ciências Médicas
2023/05/09 BDNF/TrkB-FL dysregulation is mirrored in extracellular vesicles and in cerebrospinal fluid of an Alzheimer’s disease patient series XVI CAML PhD Students Meeting
Faculdade de Medicina da Universidade de Lisboa
2023/04/11 Novel TAT-TrkB compound in Alzheimer’s disease: Rescuing BDNF-mediated synaptic plasticity and cognitive behaviour in 5xFAD mice Pizza Seminar PhD Series - Instituto de Medicina Molecular João Lobo Antunes
2023/02/01 Mapping TrkB-ICD extracellularly: Alzheimer’s disease cohort validation of BDNF receptor fragment in human cerebrospinal fluid and cargo sorting in extracellular vesicles 53ª Reunião da Sociedade Portuguesa de Farmacologia
Faculdade de Medicina da Universidade de Coimbra
2022/11 Intracellular TrkB-FL proteolytic cleavage mediates the secretion of its tyrosine kinase domain in multiple extracellular vesicle populations and overall secretome Neurosciences Seminar - Instituto de Medicina Molecular João Lobo Antunes
2022/06/20 Excitotoxic stimuli mediate BDNF receptor dysregulation mirrored in the extracellular space EpiEpiNet 2022 Summer School
University of Lund
2022/02 TrkB-FL proteolytic cleavage drives the release of a C-terminal fragment in multiple extracellular vesicle populations 52ª Reunião da Sociedade Portuguesa de Farmacogia
Faculdade de Farmácia | Universidade do Porto
2021/10 BDNF receptor cleavage promotes shedding of TrkB-ICD-containing extracellular vesicles in Alzheimer's disease Pizza Seminar PhD Series
Instituto de Medicina Molecular João Lobo Antunes | Universidade de Lisboa
2021/07 Secretion of a BDNF receptor cleavage fragment in Alzheimer's disease 35ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)
Faculdade de Medicina | Universidade de Lisboa (Portugal)
2021/05 Neuronal TrkB-ICD fragment in Alzheimer’s disease: an unexpected journey Neurosciences Seminar
Instituto de Medicina Molecular João Lobo Antunes | Universidade de Lisboa
2021/02 Vesicle dissemination of neuronal TrkB-ICD in secretome: relevance for Alzheimer's disease pathophysiology 51ª Reunião da Sociedade Portuguesa de Farmacogia
Portuguese Society of Pharmacology (Lisbon, Portugal)
2020/02 Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome/exosome signalling in Alzheimer's disease FCT-UNL Master's Scientific Committee Meeting 2020
Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa (Caparica, Portugal)
2019/12 Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome/exosome signalling in Alzheimer's disease Neurosciences Seminar
Instituto de Medicina Molecular João Lobo Antunes | Universidade de Lisboa (Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/06/05 - 2024/06/07 EpiC24 Epilepsy Conference (2024/06 - 2024/06)
Meeting (Member of the Organising Committee)
 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2023/09 - 2023/09 European Research Night 2023 – Quem é quem no teu cérebro (2023/09 - 2023/09)
Exhibition (Co-organisor)
 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2023/04 - 2023/04 Brain Awareness Week and career path after high school (2023/04 - 2023/04)
Seminar (Co-organisor)
 Universidade de Lisboa Faculdade de Medicina, Portugal
2023/03 - 2023/03 Brain Awareness Week - O cérebro Digital (2023/03 - 2023/03)
Seminar (Co-organisor)
 Universidade de Lisboa Faculdade de Medicina, Portugal
2023/01 - 2023/01 Compreender Saúde: 1ª Conferência para Professores | Understand health: 1st Conference for Professors (2023/01 - 2023/01) Fala-me Neuro, Portugal
2022/03/14 - 2022/03/20 Fala-me Neuro Event - Brain Awareness Week 2022 @ FENS Forum 2022 (2022/03/14 - 2022/03/20)
Meeting (Co-organisor)
2019 - 2019 Master's Scientific Committee Meeting - Meeting where master thesis students presented their ongoing work. (2019 - 2019)
Meeting (Co-organisor)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/05 - 2018/05 NOVA Medical School Open Day - Interaction with high school students about Neurodegenerative diseases. (2018/05 - 2018/05)
Exhibition (Member of the Organising Committee)
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017 - 2017 NOVA School of Science and Technology Open day - Experimental work and interaction with middle school and high school students about chemistry (2017 - 2017)
Exhibition (Co-organisor)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/02 - 2024/02 EpiEpiNet 2024 Winter School - Ionic channels in epilepsy & neurological diseases
Meeting
 Epileptogenesis and Epilepsy Network
2023/10 - 2023/10 Venture Creation Programme Workshop
Workshop
 Venture Creation Programme Workshop
2023/10 - 2023/10 Navigating Intellectual Property Challenges in Pharma and Biotech
Workshop
 Navigating Intellectual Property Challenges in Pharma and Biotech
2023/09 - 2023/09 EEG Hands-on Workshop
Workshop
 Epileptogenesis and Epilepsy Network
2023/08 - 2023/08 Astrocytic Control of Brain Circuits and Behavior
Meeting
 International Society for Neurochemistry
2023/07 - 2023/07 iMM Social Media Takeover
Other
 iMM Social Media Takeover
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2023/06 - 2023/06 Frontotemporal Dementia Workshop
Workshop
 37ª Reunião Anual Grupo de Estudos de Envelhecimento Cerebral e Demência
2023/03 - 2023/03 Art of Biological Things
Round table
 Cognitive Neuroscience Society, the Zoology Society and the Arts and Crafts Society
2023/02 - 2023/02 Nanoparticle Production and Characterization for Biomedical Applications
Workshop
 2nd Symposium on Alzheimer’s disease: An Update on Pathology and Therapeutics
2023/02 - 2023/02 Ciência di noz manera / Science Our Way
Exhibition
 Ciência di noz manera / Science Our Way
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2022/07/09 - 2022/07/13 FENS Forum 2022
Congress
 FENS Forum 2022
Federation of European Neuroscience Societies, Belgium
2022/06/20 - 2022/06/24 EpiEpinet: Summer School - Optogenetics, Chemogenetics, CRISPR and epilepsy models
Meeting
 EpiEpinet: Summer School - Optogenetics, Chemogenetics, CRISPR and epilepsy models
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2022/04/05 - 2022/04/05 Euro-BioImaging: Forum "At the Forefront of Neuroscience"
Seminar
 Euro-BioImaging: Forum "At the Forefront of Neuroscience"
2022/03/25 - 2022/03/25 Epilepsias no Meio Escolar
Round table
 Epilepsias no Meio Escolar
Universidade de Lisboa Faculdade de Medicina, Portugal
2022/03 - 2022/03 Brain Awareness Week 2022 - Agrupamento de Escolas de Santo António (Audience: 94 students from 6th grade)
Meeting
 Fala-me Neuro Event - Brain Awareness Week 2022
2021/12 - 2021/12 Gene Therapy Workshop
Workshop
 XVII Meeting of the Portuguese Society for Neuroscience
Sociedade Portuguesa de Neurociências, Portugal
2021/11/23 - 2021/11/24 Neuropathology of Epilepsy: from experimental models to human disease tissue
Workshop
 Neuropathology of Epilepsy: from experimental models to human disease tissue
Amsterdam Universitair Medische Centra, Netherlands
2021/11 - 2021/11 Portuguese Glial Network V Symposium - Glial cells at the crossroad of health and disease
Symposium
 Portuguese Glial Network V Symposium
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/10 - 2021/10 Symposium on Advanced Technologies on Drug Delivery
Symposium
 First Symposium on Advanced Technologies on Drug Delivery
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09 - 2021/09 Noite Europeia dos Investigadores 2021: Ciência do Clima | European Researchers’ Night 2021 SciCli
Exhibition
 Noite Europeia dos Investigadores 2021: Ciência do Clima | European Researchers’ Night 2021 SciCli
Universidade de Lisboa, Portugal

Universidade de Évora, Portugal

Universidade do Minho, Portugal

ISCTE-Instituto Universitário de Lisboa, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra, Portugal

International Iberian Nanotechnology Laboratory, Portugal

Escola Superior de Hotelaria e Turismo do Estoril, Portugal

Camara Municipal de Lisboa, Portugal
2019/12 - 2019/12 DevBioMed Symposium - From Developmental Biology to Medicine and Back
Symposium
 DevBioMed 2019 Symposium
Sociedade Portuguesa de Biologia do Desenvolvimento, Portugal

Fundação Champalimaud, Portugal
2019/10 - 2019/10 Simpósio Científico abordado o tema das Doenças Neurodegenerativas.
Symposium
 Doenças Neurodegenerativas: O que nos traz o futuro?
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/09 - 2019/09/11 Lysosome Biology - by LYSOCIL (Lysosomal Disorders and Cliopathies Research)
Workshop
 Lysosome Biology
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/07 - 2019/07 World conference on Congenital Disorders of Glycosylation for Families and Professionals
Conference
 Congenital Disorders of Glycosylation World Conference
Portuguese Association for CDG, Portugal

CDG & Allies - Professionals and Patient Associations International Network (CDG & Allies- PPAIN), Portugal
2019/06 - 2019/06 4th ICD CIIEM International Congress: Health, well-brain and ageing in the XXI century
Congress
 4th ICD CIIEM International Congress: Health, well-brain and ageing in the XXI century
Centro de Investigação Interdisciplinar Egas Moniz, Portugal
2019/05 - 2019/05 Science and Innovation Congress Switzerland-Portugal
Congress
 Science and Innovation Congress: The fascination of discoveries - tales from two countries
Fundação Champalimaud, Portugal
2019/05 - 2019/05 Portuguese Glial Network IV Symposium - Glia Diversity in Neuromodulation and Neurodegeneration
Symposium
 Portuguese Glial Network IV Symposium - Glia Diversity in Neuromodulation and Neurodegeneration
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/04/14 - 2019/04/15 Synaptic Funtion, Dysfunction and Repair - by UCL & The Discoveries Centre for Regenerative and Precision Medicine
Workshop
 Synaptic Funtion, Dysfunction and Repair
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/03 - 2019/03 Tec2Med2019 - Technology and Innovation in Medicine
Symposium
 Tec2Med - Technology and Innovation in Medicine
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/06 - 2017/06 TEDxFCTUNL talks surrounding the topic of Creativity
Seminar
 TEDx FCTUNL: Creativity
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Association member

Society Organization name Role
2021 - Current Portuguese Network on Extracellular Vesicles Member
2021 - Current Sociedade Portuguesa de Neurociências Member
2021 - Current International Student Network on Extracellular Vesicles Member
2021 - Current Fala-me Neuro Member and Designer
2019 - Current Portuguese Glial Network Member
2024/02 - 2024/02 Portuguese Society of Pharmacology Effective Member
2023/09 - 2023/09 International Society for Extracellular Vesicles Junior Member
2020/03 - 2020/07 iMM COVID-19 Diagnostic Taskforce Check-in/out staff member

Committee member

Activity description
Role 		Institution / Organization
2023/09 - Current CAML PhD Course Committee 2023/2024
Member
 Universidade de Lisboa Faculdade de Medicina, Portugal
2023/09 - Current Mind-Brain College FMUL Student Committee Representative
Member
 Universidade de Lisboa, Portugal

Consulting

Activity description Institution / Organization
2022/02 - 2022/02 Fala-me Neuro: Editor & Designer Fala-me Neuro, Portugal

Mentoring / Tutoring

Topic Student name
2022 - 2023/06/26 Master Thesis "BDNF receptor cleavage in Alzheimer`s disease: from mice to humans" Nuno Alemãn-Serrano
2023/06 - 2023/06 BDNF signalling and probing in acute hippocampal slices Ana Salomé Correia
2020 - 2022 Master thesis: "Search for novel compounds to prevent TrkB-FL cleavage" Sara Oliveira
2020 - 2022 GAPIC Project "Monitorização terapêutica do TAT-TrkB na prevenção da clivagem do recetor do BDNF (TrkB-FL) no líquido cefalorraquidiano e sangue de modelo animal" Nuno Alemãn Serrano e Rita Amaral (MD students)
Distinctions

Award

2023 Best Poster at 37ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)
2021 Best Oral Communication in Fundamental Science - 35ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)

Title

2021 Animal Laboratory Experimentation Sciences Certificate

Other distinction

2022 Individual FCT PhD Fellowship (2022)
Fundação para a Ciência e a Tecnologia, Portugal
2022 Staff Pick @ Art of Neuroscience 2022 - Community