Pedro Miguel Pimenta Gois (AD1B-6A14-C952)

Curriculum Vitae

Pedro Miguel Pimenta Gois

Pedro M. P. Gois studied chemistry at the New University of Lisbon from where he also received in 2005 his PhD in organic chemistry under the supervision of Prof. Carlos Afonso. From May 2005 to May 2008 he worked as a postdoctoral research fellow at the University of Sussex with Prof. F. Geoffrey N. Cloke FRS, at the University College of London with Prof. Stephen Caddick and at the Instituto Superior Técnico (Technical University of Lisbon) with Prof. Carlos Afonso. In May 2008, he joined the Pharmacy Faculty of the Lisbon University as an assistant research fellow of the medicinal chemistry group (iMed.UL – Research Institute for Medicines) and in July 2013, Gois was appointed Principal Investigator at the same institution and head of the Bioorganic group. In 2017 he received his habilitation in Pharmacy and was appointed assistant professor of the Pharmacy Faculty.

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Identificação

Identificação pessoal

Nome completo: Pedro Miguel Pimenta Gois

Nomes de citação

Gois, Pedro
Gois PMP

Identificadores de autor

Ciência ID: AD1B-6A14-C952
ORCID iD: 0000-0002-7698-630X
Researcher Id: A-9251-2014
Scopus Author Id: 6507726637

Domínios de atuação

Ciências Exatas - Química - Química Orgânica

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador independente (B1)	Utilizador proficiente (C1)
Espanhol; Castelhano	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador elementar (A1)	Utilizador independente (B1)
Francês	Utilizador elementar (A1)	Utilizador independente (B1)	Utilizador elementar (A1)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2016/08/10 Concluído	Agregação em Farmácia (Título de Agregado) Universidade de Lisboa Faculdade de Farmácia, Portugal "Agregação em Farmácia" (TESE/DISSERTAÇÃO)	Aprovado por Unanimidade
2005/05/03 - 2008/04/01 Concluído	Pos-Doc (Pós-doutoramento) Especialização em Catalysis university college of london Chemistry Detarment, Reino Unido University of Sussex Department of Chemistry and Biochemistry, Reino Unido Universidade de Lisboa Instituto Superior Técnico, Portugal
2005 Concluído	Quimica Orgânica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Studies on the di-rhodium (II) catalysed cyclisation of 2-diazo-2-dietoxyphosphoryl-acetamidas" (TESE/DISSERTAÇÃO)	Aproved by Unanimity
2005 Concluído	Química (Doutoramento) Especialização em Especialidade: Química Orgânica Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Estudo Sobre a Ciclização de 2-diazo2dietoxifosforil-acetamidas Catalizada por Catalizadores de Di-ródio (ii)" (TESE/DISSERTAÇÃO)
2000/09/07 Concluído	Química Aplicada (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal	16 valores

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2008/05/02 - 2013/07/02	Investigador Contratado (Investigação)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2013 - 2016	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2020/01/17 - Atual	Executive Board member of iMed.Ulisboa	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

2012/01/01 - Atual	Head of the Bioorganic Group of iMed.Ulisboa	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2017/02/01 - Atual	Assistant Professor with Habilitation	Universidade de Lisboa Faculdade de Farmácia, Portugal

2013/07/02 - 2017	Principal investigator FCT Investigator - Development grant	Universidade de Lisboa Faculdade de Farmácia, Portugal

1999/06/01 - 1999/09/01	Pratical Course on the “Investigation of Grignard raction and by-products”	Universitetet i Bergen Kjemisk institutt, Noruega

1998/02/01 - 1998/07/30	Laboratory assistant of the Química II discipline	Universidade Nova de Lisboa Departamento de Química, Portugal

Projetos

Bolsa

	Designação	Financiadores
2022/01/17 - 2025/01/17	SmartBox: Engineering the first generation of ROS responsive ADCs PTDC/QUI-OUT/3989/2021 Investigador responsável FARM-ID, Associção da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARMID) , Portugal Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Em curso

Projeto

	Designação	Financiadores
2021/03/01 - Atual	1Pot2Cat: One-pot bimetallic catalyzed synthesis of challenging N-heterocycles PTDC/QUI-QOR/0712/2020 Co-Investigador Responsável (Co-IR) FARM-ID, Associção da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARMID) , Portugal	Em curso

Produções

Publicações

Artigo em revista

Silva, Maria J. S. A.; Zhang, Yiyi; Vinck, Robin; Santos, Fábio M. F.; António, João P. M.; Gourdon-Grünewaldt, Lisa; Zaouter, Charlotte; et al. "BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation". Bioconjugate Chemistry 34 12 (2023): 2337-2344. http://dx.doi.org/10.1021/acs.bioconjchem.3c00449.
10.1021/acs.bioconjchem.3c00449
Padanha, Rita; Cavadas, Rafaela A. N.; Merino, Pedro; António, João P. M.; Gois, Pedro M. P.. "N-Terminal Cysteine Bioconjugation with (2-Cyanamidophenyl)boronic Acids Enables the Direct Formation of Benzodiazaborines on Peptides". Organic Letters 25 29 (2023): 5476-5480. http://dx.doi.org/10.1021/acs.orglett.3c01835.
10.1021/acs.orglett.3c01835
Gois, Pedro M. P.; António, João P. M.; Monteiro, Sofia A. G.. "Boronic Acids and Beyond: ROS-Responsive Prodrugs as Tools for a Safer and More Effective Cancer Chemotherapy". Synlett 34 18 (2023): 2129-2158. http://dx.doi.org/10.1055/a-2132-1356.
10.1055/a-2132-1356
Matos, Ana I.; Peres, Carina; Carreira, Barbara; Moura, Liane I. F.; Acúrcio, Rita C.; Vogel, Theresa; Wegener, Erik; et al. "Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors". Advanced Science 10 25 (2023): http://dx.doi.org/10.1002/advs.202300299.
10.1002/advs.202300299
Felicidade, João; Santos, Fabio M. F.; Arteaga, Jesús F.; Remón, Patricia; Campos-González, René; Nguyen, Ha-Chi; Nájera, Francisco; et al. "Engineering the BASHY Dye Platform toward Architectures with Responsive Fluorescence". Chemistry – A European Journal 29 31 (2023): http://dx.doi.org/10.1002/chem.202300579.
10.1002/chem.202300579
André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra; Nogueira, Sara; Bule, Pedro; Carvalho, Joana Inês; António, João P. M.; et al. "Rabbit derived VL single-domains as promising scaffolds to generate antibody–drug conjugates". Scientific Reports 13 1 (2023): http://dx.doi.org/10.1038/s41598-023-31568-x.
10.1038/s41598-023-31568-x
Silva, Maria J. S. A.; Cavadas, Rafaela A. N.; Faustino, Hélio; Veiros, Luís F.; Gois, Pedro M. P.. "Interactive Bioconjugation at N -Terminal Cysteines by Using O -Salicylaldehyde Esters towards Dual Site-Selective Functionalization". Chemistry – A European Journal 28 67 (2022): http://dx.doi.org/10.1002/chem.202202377.
10.1002/chem.202202377
Afonso, Cláudia F.; Marques, Marta C.; António, João P. M.; Cordeiro, Carlos; Gois, Pedro M. P.; Cal, Pedro M. S. D.; Bernardes, Gonçalo J. L.. "Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones". Angewandte Chemie International Edition 61 46 (2022): http://dx.doi.org/10.1002/anie.202208543.
10.1002/anie.202208543
Mariama Djaló; Maria J. S. A. Silva; Hélio Faustino; Sandra N. Pinto; Ricardo Mendonça; Pedro M. P. Gois. "Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues". Chemical Communications 58 (2022): 7928-7931.
10.1039/d2cc02204d
Poeira, Diogo L.; Negrão, Ana Cláudia R.; Faustino, Hélio; Coelho, Jaime A. S.; Gomes, Clara S. B.; Gois, Pedro M. P.; Marques, M. Manuel B.. "Hypervalent Iodine(III) Reagents with Transferable Primary Amines: Structure and Reactivity on the Electrophilic a-Amination of Stabilized Enolates". Organic Letters 24 2 (2022): 776-781. http://dx.doi.org/10.1021/acs.orglett.1c04312.
10.1021/acs.orglett.1c04312
Baldo, Silvia; Antunes, Patrícia; Felicidade, João Falcão; Santos, Fábio M. F.; Arteaga, Jesús F.; Fernandes, Fábio; Pischel, Uwe; Pinto, Sandra N.; Gois, Pedro M. P.. "The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib–GV1001 Conjugate". ACS Medicinal Chemistry Letters 13 1 (2021): 128-133. http://dx.doi.org/10.1021/acsmedchemlett.1c00615.
10.1021/acsmedchemlett.1c00615
Pinto, Maria V.; Santos, Fábio M. F.; Barros, Catarina; Ribeiro, Ana Rita; Pischel, Uwe; Gois, Pedro M. P.; Fernandes, Adelaide. "BASHY Dye Platform Enables the Fluorescence Bioimaging of Myelin Debris Phagocytosis by Microglia during Demyelination". Cells 10 11 (2021): 3163. http://dx.doi.org/10.3390/cells10113163.
10.3390/cells10113163
António, João P. M.; Carvalho, Joana Inês; André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra I.; Faustino, Hélio; Lopes, Ricardo M. R. M.; et al. "Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates". Angewandte Chemie International Edition 60 49 (2021): 25914-25921. http://dx.doi.org/10.1002/anie.202109835.
10.1002/anie.202109835
Zegota, Maksymilian Marek; Müller, Michael Andreas; Lantzberg, Bellinda; Kizilsavas, Gönül; Coelho, Jaime A. S.; Moscariello, Pierpaolo; Martínez-Negro, María; et al. "Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments". Journal of the American Chemical Society 143 41 (2021): 17047-17058. http://dx.doi.org/10.1021/jacs.1c06559.
10.1021/jacs.1c06559
Lopes, Raquel R.; Tomé, Catarina S.; Russo, Roberto; Paterna, Roberta; Leandro, João; Candeias, Nuno R.; Gonçalves, Lídia M. D.; et al. "Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives". Biomolecules 11 3 (2021): 462. http://dx.doi.org/10.3390/biom11030462.
10.3390/biom11030462
Silva, Maria J. S. A.; Gois, Pedro M. P.; Gasser, Gilles. "Unveiling the Potential of Transition Metal Complexes for Medicine: Translational in Situ Activation of Metal-Based Drugs from Bench to in Vivo Applications". ChemBioChem 22 10 (2021): 1740-1742. http://dx.doi.org/10.1002/cbic.202100015.
10.1002/cbic.202100015
José, Maria; Faustino, Hélio; Coelho, Jaime; Vaz Pinto, Maria; Fernandes, Adelaide; companon, ismael; Corzana, Francisco; et al. "Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides". Angewandte Chemie International Edition (2021): http://dx.doi.org/10.1002/anie.202016936.
10.1002/anie.202016936
António, João P. M.; Faustino, Hélio; Gois, Pedro M. P.. "A 2-formylphenylboronic acid (2FPBA)-maleimide crosslinker: a versatile platform for Cys-peptide–hydrazine conjugation and interplay". Organic & Biomolecular Chemistry 19 28 (2021): 6221-6226. http://dx.doi.org/10.1039/d1ob00917f.
10.1039/d1ob00917f
Xu, Lujuan; Silva, Maria J. S. A.; Gois, Pedro M. P.; Kuan, Seah Ling; Weil, Tanja. "Chemoselective cysteine or disulfide modification via single atom substitution in chloromethyl acryl reagents". Chemical Science 12 40 (2021): 13321-13330. http://dx.doi.org/10.1039/d1sc03250j.
10.1039/d1sc03250j
Paterna, Roberta; Padanha, Rita; Russo, Roberto; Frade, Raquel F.M.; Faustino, Hélio; Gois, Pedro M.P.. "Synthesis of 4-substituted-3-Hydroxyquinolin-2(1H)-ones with anticancer activity". Tetrahedron 76 51 (2020): 130983. http://dx.doi.org/10.1016/j.tet.2020.130983.
10.1016/j.tet.2020.130983
Russo, Roberto; Padanha, Rita; Fernandes, Fábio; Veiros, Luis F.; Corzana, Francisco; Gois, Pedro M. P.. "Engineering Boron Hot Spots for the Site-Selective Installation of Iminoboronates on Peptide Chains". Chemistry – A European Journal 26 66 (2020): 15226-15231. http://dx.doi.org/10.1002/chem.202002675.
10.1002/chem.202002675
Santos, Fábio M. F.; Domínguez, Zoe; Fernandes, João P. L.; Parente Carvalho, Cátia; Collado, Daniel; Pérez-Inestrosa, Ezequiel; Pinto, Maria V.; et al. "Cyanine-Like Boronic Acid-Derived Salicylidenehydrazone Complexes (Cy-BASHY) for Bioimaging Applications". Chemistry – A European Journal 26 62 (2020): 14064-14069. http://dx.doi.org/10.1002/chem.202001623.
10.1002/chem.202001623
Lozano, Ana; Pamplona, Beatriz; Kilich, Tymon; Labuda, Marta; Mendes, Mónica; Pereira-da-Silva, João; García, Gustavo; et al. "The Role of Electron Transfer in the Fragmentation of Phenyl and Cyclohexyl Boronic Acids". International Journal of Molecular Sciences 20 22 (2019): 5578. http://dx.doi.org/10.3390/ijms20225578.
10.3390/ijms20225578
Hebel, Marco; Riegger, Andreas; Zegota, Maksymilian M.; Kizilsavas, Gönül; Gacanin, Jasmina; Pieszka, Michaela; Lückerath, Thorsten; et al. "Sequence Programming with Dynamic Boronic Acid/Catechol Binary Codes". Journal of the American Chemical Society 141 36 (2019): 14026-14031. http://dx.doi.org/10.1021/jacs.9b03107.
Publicado • 10.1021/jacs.9b03107
Conniot, João; Scomparin, Anna; Peres, Carina; Yeini, Eilam; Pozzi, Sabina; Matos, Ana I.; Kleiner, Ron; et al. "Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators". Nature Nanotechnology 14 9 (2019): 891-901. http://dx.doi.org/10.1038/s41565-019-0512-0.
10.1038/s41565-019-0512-0
Poeira, Diogo L.; Macara, João; Faustino, Hélio; Coelho, Jaime A. S.; Gois, Pedro M. P.; Marques, M. Manuel B.. "Hypervalent Iodine Mediated Sulfonamide Synthesis". European Journal of Organic Chemistry 2019 15 (2019): 2695-2701. http://dx.doi.org/10.1002/ejoc.201900259.
10.1002/ejoc.201900259
António, João P. M.; Russo, Roberto; Carvalho, Cátia Parente; Cal, Pedro M. S. D.; Gois, Pedro M. P.. "Boronic acids as building blocks for the construction of therapeutically useful bioconjugates". Chemical Society Reviews 48 13 (2019): 3513-3536. http://dx.doi.org/10.1039/c9cs00184k.
10.1039/c9cs00184k
Ravasco, João M. J. M.; Faustino, Hélio; Trindade, Alexandre; Gois, Pedro M. P.. "Bioconjugation with Maleimides: A Useful Tool for Chemical Biology". Chemistry – A European Journal 25 1 (2018): 43-59. http://dx.doi.org/10.1002/chem.201803174.
10.1002/chem.201803174
Jiménez, Vicente G.; Santos, Fábio M. F.; Castro-Fernández, Silvia; Cuerva, Juan M.; Gois, Pedro M. P.; Pischel, Uwe; Campaña, Araceli G.. "Circularly Polarized Luminescence of Boronic Acid-Derived Salicylidenehydrazone Complexes Containing Chiral Boron as Stereogenic Unit". The Journal of Organic Chemistry 83 22 (2018): 14057-14062. http://dx.doi.org/10.1021/acs.joc.8b01844.
10.1021/acs.joc.8b01844
Santos, Fábio M. F.; Domínguez, Zoe; Alcaide, María M.; Matos, Ana I.; Florindo, Helena F.; Candeias, Nuno R.; Gois, Pedro M. P.; Pischel, Uwe. "Highly Efficient Energy Transfer Cassettes by Assembly of Boronic Acid Derived Salicylidenehydrazone Complexes". ChemPhotoChem 2 12 (2018): 1038-1045. http://dx.doi.org/10.1002/cptc.201800150.
10.1002/cptc.201800150
Lopes, Ricardo M. R. M.; Ventura, Ana E.; Silva, Liana C.; Faustino, Hélio; Gois, Pedro M. P.. "N,O -Iminoboronates: Reversible Iminoboronates with Improved Stability for Cancer Cells Targeted Delivery". Chemistry - A European Journal 24 48 (2018): 12495-12499. http://dx.doi.org/10.1002/chem.201802515.
10.1002/chem.201802515
António, João P. M.; Gonçalves, Lídia M.; Guedes, Rita C.; Moreira, Rui; Gois, Pedro M. P.. "Diazaborines as New Inhibitors of Human Neutrophil Elastase". ACS Omega 3 7 (2018): 7418-7423. http://dx.doi.org/10.1021/acsomega.8b00702.
10.1021/acsomega.8b00702
Alcaide, María M.; Santos, Fabio M. F.; Pais, Vânia F.; Carvalho, Joana Inês; Collado, Daniel; Pérez-Inestrosa, Ezequiel; Arteaga, Jesús F.; et al. "Electronic and Functional Scope of Boronic Acid Derived Salicylidenehydrazone (BASHY) Complexes as Fluorescent Dyes". The Journal of Organic Chemistry 82 14 (2017): 7151-7158. http://dx.doi.org/10.1021/acs.joc.7b00601.
10.1021/acs.joc.7b00601
Cal, Pedro M. S. D.; Sieglitz, Florian; Santos, Fábio M. F.; Parente Carvalho, Cátia; Guerreiro, Ana; Bertoldo, Jean B.; Pischel, Uwe; Gois, Pedro M. P.; Bernardes, Gonçalo J. L.. "Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells". Chemical Communications 53 2 (2017): 368-371. http://dx.doi.org/10.1039/c6cc08671c.
10.1039/c6cc08671c
Santos, F.M.F.; Matos, A.I.; Ventura, A.E.; Gonçalves, J.; Veiros, L.F.; Florindo, H.F.; Gois, P.M.P.; et al. "Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates". Angewandte Chemie - International Edition 56 32 (2017): 9346-9350. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022198030&partnerID=MN8TOARS.
10.1002/anie.201703492
Nunes, Mário A.P.; Gois, Pedro M.P.; Rosa, M. Emilia; Martins, Samuel; Fernandes, Pedro C.B.; Ribeiro, Maria H.L.. "Boronic acids as efficient cross linkers for PVA: synthesis and application of tunable hollow microspheres in biocatalysis". Tetrahedron 72 46 (2016): 7293-7305. http://dx.doi.org/10.1016/j.tet.2016.02.017.
10.1016/j.tet.2016.02.017
Nunes, Mário A.P.; Martins, Samuel; Rosa, M. Emilia; Gois, Pedro M.P.; Fernandes, Pedro C.B.; Ribeiro, Maria H.L.. "Improved thermostable polyvinyl alcohol electrospun nanofibers with entangled naringinase used in a novel mini-packed bed reactor". Bioresource Technology 213 (2016): 208-215. http://dx.doi.org/10.1016/j.biortech.2016.03.058.
10.1016/j.biortech.2016.03.058
Candeias, Nuno R.; Paterna, Roberta; Gois, Pedro M. P.. "Homologation Reaction of Ketones with Diazo Compounds". Chemical Reviews 116 5 (2016): 2937-2981. http://dx.doi.org/10.1021/acs.chemrev.5b00381.
10.1021/acs.chemrev.5b00381
Faustino, Hélio; Silva, Maria J. S. A.; Veiros, Luís F.; Bernardes, Gonçalo J. L.; Gois, Pedro M. P.. "Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation". Chemical Science 7 8 (2016): 5052-5058. http://dx.doi.org/10.1039/c6sc01520d.
10.1039/c6sc01520d
Akkapeddi, Padma; Azizi, Saara-Anne; Freedy, Allyson M.; Cal, Pedro M. S. D.; Gois, Pedro M. P.; Bernardes, Gonçalo J. L.. "Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry". Chemical Science 7 5 (2016): 2954-2963. http://dx.doi.org/10.1039/c6sc00170j.
10.1039/c6sc00170j
Cal, P.M.S.D.; Frade, R.F.M.; Cordeiro, C.; Gois, P.M.P.. "Corrigendum to: Reversible Lysine Modification on Proteins by Using Functionalized Boronic Acids (Chem. Eur. J., (2015), 21, (8182-8187), 10.1002/chem.201500127)". Chemistry - A European Journal 22 47 (2016): 16711-16711. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994424448&partnerID=MN8TOARS.
10.1002/chem.201503646
Santos, Fábio M. F.; Rosa, João N.; Candeias, Nuno R.; Carvalho, Cátia Parente; Matos, Ana I.; Ventura, Ana E.; Florindo, Helena F.; et al. "A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Chemistry - A European Journal 22 5 (2015): 1537-1537. http://dx.doi.org/10.1002/chem.201504919.
10.1002/chem.201504919
Cal, Pedro M. S. D.; Frade, Raquel F. M.; Cordeiro, Carlos; Gois, Pedro M. P.. "Reversible Lysine Modification on Proteins by Using Functionalized Boronic Acids". Chemistry - A European Journal 21 22 (2015): 8182-8187. http://dx.doi.org/10.1002/chem.201500127.
10.1002/chem.201500127
Lombard, Fanny J.; Coster, Mark J.. "Rhodium(ii)-catalysed intramolecular C–H insertion a- to oxygen: reactivity, selectivity and applications to natural product synthesis". Organic & Biomolecular Chemistry 13 23 (2015): 6419-6431. http://dx.doi.org/10.1039/c5ob00311c.
10.1039/c5ob00311c
Rosholm, Tomi; Gois, Pedro M. P.; Franzen, Robert; Candeias, Nuno R.. "Glycerol as an Efficient Medium for the Petasis Borono-Mannich Reaction". ChemistryOpen 4 1 (2014): 39-46. http://dx.doi.org/10.1002/open.201402066.
10.1002/open.201402066
Cal, Pedro M. S. D.; Bernardes, Gonçalo J. L.; Gois, Pedro M. P.. "Cysteine-Selective Reactions for Antibody Conjugation". Angewandte Chemie International Edition 53 40 (2014): 10585-10587. http://dx.doi.org/10.1002/anie.201405702.
10.1002/anie.201405702
Almeida, Ana R.; Dias, Roberto D.; Monteiro, Carlos J. P.; Abreu, Artur R.; Gois, Pedro M. P.; Bayon, J. Carles; Pereira, Mariette M.. "Rhodium-Catalysed Tandem Hydroformylation/Arylation Reaction with Boronic Acids". Advanced Synthesis & Catalysis 356 6 (2014): 1223-1228. http://dx.doi.org/10.1002/adsc.201300968.
10.1002/adsc.201300968
Montalbano, Francesco; Leandro, João; Farias, Gonçalo D. V. F.; Lino, Paulo R.; Guedes, Rita C.; Vicente, João B.; Leandro, Paula; Gois, Pedro M. P.. "Phenylalanine iminoboronates as new phenylalanine hydroxylase modulators". RSC Adv. 4 105 (2014): 61022-61027. http://dx.doi.org/10.1039/c4ra10306h.
10.1039/c4ra10306h
António, João P. M.; Frade, Raquel F. M.; Santos, Fábio M. F.; Coelho, Jaime A. S.; Afonso, Carlos A. M.; Gois, Pedro M. P.; Trindade, Alexandre F.. "NHC catalysed direct addition of HMF to diazo compounds: synthesis of acyl hydrazones with antitumor activity". RSC Adv. 4 55 (2014): 29352-29356. http://dx.doi.org/10.1039/c4ra03710c.
10.1039/c4ra03710c
Cal, Pedro M. S. D.; Frade, Raquel F. M.; Chudasama, Vijay; Cordeiro, Carlos; Caddick, Stephen; Gois, Pedro M. P.. "Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates". Chem. Commun. 50 40 (2014): 5261-5263. http://dx.doi.org/10.1039/c3cc47534d.
10.1039/c3cc47534d
Paterna, Roberta; André, Vânia; Duarte, M. Teresa; Veiros, Luis F.; Candeias, Nuno R.; Gois, Pedro M. P.. "Ring-Expansion Reaction of Isatins with Ethyl Diazoacetate Catalyzed by Dirhodium(II)/DBU Metal-Organic System: En Route to Viridicatin Alkaloids". European Journal of Organic Chemistry 2013 28 (2013): 6280-6290. http://dx.doi.org/10.1002/ejoc.201300796.
10.1002/ejoc.201300796
Santos, Fábio M. F.; Rosa, João N.; André, Vânia; Duarte, M. Teresa; Veiros, Luís F.; Gois, Pedro M. P.. "N-Heterocyclic Carbene Catalyzed Addition of Aldehydes to Diazo Compounds: Stereoselective Synthesis of N-Acylhydrazones". Organic Letters 15 7 (2013): 1760-1763. http://dx.doi.org/10.1021/ol400563w.
10.1021/ol400563w
Coelho, Jaime A. S.; Trindade, Alexandre F.; Wanke, Riccardo; Rocha, Bruno G. M.; Veiros, Luis F.; Gois, Pedro M. P.; Pombeiro, Armando J. L.; Afonso, Carlos A. M.. "N-Heterocyclic Carbene Dirhodium(II) Complexes as Catalysts for Allylic and Benzylic Oxidations". European Journal of Organic Chemistry 2013 8 (2013): 1471-1478. http://dx.doi.org/10.1002/ejoc.201201300.
10.1002/ejoc.201201300
Montalbano, Francesco; Cal, Pedro M. S. D.; Carvalho, Marta A. B. R.; Gonçalves, Lídia M.; Lucas, Susana D.; Guedes, Rita C.; Veiros, Luís F.; Moreira, Rui; Gois, Pedro M. P.. "Discovery of new heterocycles with activity against human neutrophile elastase based on a boron promoted one-pot assembly reaction". Organic & Biomolecular Chemistry 11 27 (2013): 4465. http://dx.doi.org/10.1039/c3ob40614h.
10.1039/c3ob40614h
Candeias, Nuno R.; Carias, Carolina; Gomes, Luis F. R.; André, Vânia; Duarte, M. Teresa; Gois, Pedro M. P.; Afonso, Carlos A. M.. "Asymmetric Intramolecular C-H Insertion of a-Diazoacetamides in Water by Dirhodium(II) Catalysts Derived from Natural Amino Acids". Advanced Synthesis & Catalysis 354 16 (2012): 2921-2927. http://dx.doi.org/10.1002/adsc.201200101.
10.1002/adsc.201200101
Cal, Pedro M. S. D.; Vicente, João B.; Pires, Elisabete; Coelho, Ana V.; Veiros, Lui´s F.; Cordeiro, Carlos; Gois, Pedro M. P.. "Iminoboronates: A New Strategy for Reversible Protein Modification". Journal of the American Chemical Society 134 24 (2012): 10299-10305. http://dx.doi.org/10.1021/ja303436y.
10.1021/ja303436y
Candeias, Nuno R.; Paterna, Roberta; Cal, Pedro M. S. D.; Góis, Pedro M. P.. "A Sustainable Protocol for the Aqueous Multicomponent Petasis Borono–Mannich Reaction". Journal of Chemical Education 89 6 (2012): 799-802. http://dx.doi.org/10.1021/ed200509q.
10.1021/ed200509q
Trindade, Alexandre F.; Coelho, Jaime A. S.; Afonso, Carlos A. M.; Veiros, Luis F.; Gois, Pedro M. P.. "Fine Tuning of Dirhodium(II) Complexes: Exploring the Axial Modification". ACS Catalysis 2 3 (2012): 370-383. http://dx.doi.org/10.1021/cs200597a.
10.1021/cs200597a
Montalbano, Francesco; Candeias, Nuno R.; Veiros, Luís F.; André, Vânia; Duarte, M. Teresa; Bronze, Maria R.; Moreira, Rui; Gois, Pedro M. P.. "Four-Component Assembly of Chiral N–B Heterocycles with a Natural Product-Like Framework". Organic Letters 14 4 (2012): 988-991. http://dx.doi.org/10.1021/ol203224n.
10.1021/ol203224n
Candeias, Nuno R.; Afonso, Carlos A. M.; Gois, Pedro M. P.. "Making expensive dirhodium(ii) catalysts cheaper: Rh(ii) recycling methods". Organic & Biomolecular Chemistry 10 17 (2012): 3357. http://dx.doi.org/10.1039/c2ob06731e.
10.1039/c2ob06731e
Zakrzewska, M.E.; Cal, P.M.S.D.; Candeias, N.R.; Bogel-Lukasik, R.; Afonso, C.A.M.; Ponte, M.N.; Gois, P.M.P.. "Intramolecular C-H insertion catalyzed by dirhodium(II) complexes using CO2as the reaction media". Green Chemistry Letters and Reviews 5 2 (2012): 211-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859505886&partnerID=MN8TOARS.
10.1080/17518253.2011.620009
R. Almeida, Ana; F. Peixoto, Andreia; J. F. Calvete, Mario; M. P. Gois, Pedro; M. Pereira, Mariette. "Rhodium(I) N-Heterocyclic Carbene Complexes as Catalysts for Hydroformylation of Olefins: An Overview". Current Organic Synthesis 8 5 (2011): 764-775. http://dx.doi.org/10.2174/157017911796957339.
10.2174/157017911796957339
Vila-Real, Helder; Alfaia, António J.; Rosa, João N.; Gois, Pedro M.P.; Rosa, M. Emilia; Calado, António R.T.; Ribeiro, Maria H.. "a-Rhamnosidase and ß-glucosidase expressed by naringinase immobilized on new ionic liquid sol–gel matrices: Activity and stability studies". Journal of Biotechnology 152 4 (2011): 147-158. http://dx.doi.org/10.1016/j.jbiotec.2010.08.005.
10.1016/j.jbiotec.2010.08.005
Reddy, R. Sudarshan; Rosa, João N.; Veiros, Luís F.; Caddick, Stephen; Gois, Pedro M. P.. "NHC/Iron cooperative catalysis: aerobic oxidative esterification of aldehydes with phenols". Organic & Biomolecular Chemistry 9 9 (2011): 3126. http://dx.doi.org/10.1039/c1ob05151b.
10.1039/c1ob05151b
Candeias, Nuno R.; Montalbano, Francesco; Cal, Pedro M. S. D.; Gois, Pedro M. P.. "Boronic Acids and Esters in the Petasis-Borono Mannich Multicomponent Reaction". Chemical Reviews 110 10 (2010): 6169-6193. http://dx.doi.org/10.1021/cr100108k.
10.1021/cr100108k
Trindade, Alexandre F.; André, Vânia; Duarte, M. Teresa; Veiros, Luís F.; Gois, Pedro M.P.; Afonso, Carlos A.M.. "Selective arylation of aldehydes with di-rhodium(II)/NHC catalysts". Tetrahedron 66 44 (2010): 8494-8502. http://dx.doi.org/10.1016/j.tet.2010.08.050.
10.1016/j.tet.2010.08.050
Rosa, Joa~o N.; Reddy, R. Sudarshan; Candeias, Nuno R.; Cal, Pedro M. S. D.; Gois, Pedro M. P.. "NHC-Iron-Catalyzed Aerobic Oxidative Aromatic Esterification of Aldehydes using Boronic Acids". Organic Letters 12 12 (2010): 2686-2689. http://dx.doi.org/10.1021/ol100302e.
10.1021/ol100302e
Frade, Raquel F.M.; Candeias, Nuno R.; Duarte, Catarina M.M.; André, Vânia; Teresa Duarte, M.; Gois, Pedro M.P.; Afonso, Carlos A.M.. "New dirhodium complex with activity towards colorectal cancer". Bioorganic & Medicinal Chemistry Letters 20 11 (2010): 3413-3415. http://dx.doi.org/10.1016/j.bmcl.2010.04.002.
10.1016/j.bmcl.2010.04.002
Candeias, Nuno R.; Cal, Pedro M.S.D.; André, Vânia; Duarte, M. Teresa; Veiros, Luís F.; Gois, Pedro M.P.. "Water as the reaction medium for multicomponent reactions based on boronic acids". Tetrahedron 66 14 (2010): 2736-2745. http://dx.doi.org/10.1016/j.tet.2010.01.084.
10.1016/j.tet.2010.01.084
Afonso, Carlos; Gomes, Luis; Trindade, Alexandre; Candeias, Nuno; Veiros, Luís; Gois, Pedro. "Cyclization of Diazoacetamides Catalyzed by N-Heterocyclic Carbene Dirhodium(II) Complexes". Synthesis 2009 20 (2009): 3519-3526. http://dx.doi.org/10.1055/s-0029-1217005.
10.1055/s-0029-1217005
Candeias, Nuno R.; Branco, Luís C.; Gois, Pedro M. P.; Afonso, Carlos A. M.; Trindade, Alexandre F.. "More Sustainable Approaches for the Synthesis of N-Based Heterocycles". Chemical Reviews 109 6 (2009): 2703-2802. http://dx.doi.org/10.1021/cr800462w.
10.1021/cr800462w
Candeias, Nuno R.; Veiros, Luís F.; Afonso, Carlos A. M.; Gois, Pedro M. P.. "Water: A Suitable Medium for the Petasis Borono-Mannich Reaction". European Journal of Organic Chemistry 2009 12 (2009): 1859-1863. http://dx.doi.org/10.1002/ejoc.200900056.
10.1002/ejoc.200900056
Esposito, Oriana; Gois, Pedro M. P.; de K. Lewis, Alexandra K.; Caddick, Stephen; Cloke, F. Geoffrey N.; Hitchcock, Peter B.. "Alkylpalladium N-Heterocyclic Carbene Complexes: Synthesis, Reactivity, and Catalytic Properties". Organometallics 27 24 (2008): 6411-6418. http://dx.doi.org/10.1021/om800455h.
10.1021/om800455h
Gomes, Luis F.R.; Trindade, Alexandre F.; Candeias, Nuno R.; Gois, Pedro M.P.; Afonso, Carlos A.M.. "Intramolecular C–H insertion using NHC–di-rhodium(II) complexes: the influence of axial coordination". Tetrahedron Letters 49 52 (2008): 7372-7375. http://dx.doi.org/10.1016/j.tetlet.2008.10.054.
10.1016/j.tetlet.2008.10.054
Candeias, Nuno R.; Gois, Pedro M. P.; Veiros, Luis F.; Afonso, Carlos A. M.. "C-H Carbene Insertion of a-Diazo Acetamides by Photolysis in Non-Conventional Media". The Journal of Organic Chemistry 73 15 (2008): 5926-5932. http://dx.doi.org/10.1021/jo800980c.
10.1021/jo800980c
Trindade, Alexandre F.; Gois, Pedro M. P.; Veiros, Lui´s F.; Andre´, Va^nia; Duarte, M. Teresa; Afonso, Carlos A. M.; Caddick, Stephen; Cloke, F. Geoffrey N.. "Axial Coordination of NHC Ligands on Dirhodium(II) Complexes: Generation of a New Family of Catalysts". The Journal of Organic Chemistry 73 11 (2008): 4076-4086. http://dx.doi.org/10.1021/jo800087n.
10.1021/jo800087n
Gois, Pedro M. P.; Trindade, Alexandre F.; Veiros, Luís F.; André, Vania; Duarte, M. Teresa; Afonso, Carlos A. M.; Caddick, Stephen; Cloke, F. Geoffrey N.. "Tuning the Reactivity of Dirhodium(II) Complexes with Axial N-Heterocyclic Carbene Ligands: The Arylation of Aldehydes". Angewandte Chemie 119 30 (2007): 5852-5855. http://dx.doi.org/10.1002/ange.200700924.
10.1002/ange.200700924
Afonso, Carlos A. M.; Branco, Luís C.; Candeias, Nuno R.; Gois, Pedro M. P.; Lourenço, Nuno M. T.; Mateus, Nuno M. M.; Rosa, João N.. "Efficient catalyst reuse by simple dissolution in non-conventional media". Chem. Commun. 26 (2007): 2669-2679. http://dx.doi.org/10.1039/b607483a.
10.1039/b607483a
Candeias, Nuno R.; Gois, Pedro M. P.; Afonso, Carlos A. M.. "Rh(II)-Catalyzed Intramolecular C-H Insertion of Diazo Substrates in Water: Scope and Limitations". The Journal of Organic Chemistry 71 15 (2006): 5489-5497. http://dx.doi.org/10.1021/jo060397a.
10.1021/jo060397a
Branco, Luís C.; Gois, Pedro M. P.; Lourenço, Nuno M. T.; Kurteva, Vanya B.; Afonso, Carlos A. M.. "Simple transformation of crystalline chiral natural anions to liquid medium and their use to induce chirality". Chem. Commun. 22 (2006): 2371-2372. http://dx.doi.org/10.1039/b600816j.
10.1039/b600816j
P. Gois, Pedro M.; Candeias, Nuno R.; Afonso, Carlos A.M.. "Preparation of enantioselective enriched a-(dialkoxyphosphoryl)lactams via intramolecular CH insertion with chiral dirhodium(II) catalysts". Journal of Molecular Catalysis A: Chemical 227 1-2 (2005): 17-24. http://dx.doi.org/10.1016/j.molcata.2004.09.041.
10.1016/j.molcata.2004.09.041
Candeias, Nuno R.; Gois, Pedro M. P.; Afonso, Carlos A. M.. "Rh(ii) catalysed intramolecular C–H insertion of diazo substrates in water: a simple and efficient approach to catalyst reuse". Chem. Commun. 3 (2005): 391-393. http://dx.doi.org/10.1039/b414233k.
10.1039/b414233k
Gois, Pedro M. P.; Afonso, Carlos A. M.. "Stereo- and Regiocontrol in the Formation of Lactams by Rhodium-Carbenoid C-H Insertion ofa-Diazoacetamides". European Journal of Organic Chemistry 2004 18 (2004): 3773-3788. http://dx.doi.org/10.1002/ejoc.200400237.
10.1002/ejoc.200400237
Gois, Pedro M. P.; Afonso, Carlos A. M.. "Dirhodium(II)-Catalyzed C—H Insertion on a-Diazo-a-phosphono-acetamides in an Ionic Liquid.". ChemInform 34 48 (2003): http://dx.doi.org/10.1002/chin.200348148.
10.1002/chin.200348148
Gois, Pedro M. P.; Afonso, Carlos A. M.. "Regio- and Stereoselective Dirhodium(II)-Catalysed Intramolecular C-H Insertion Reactions ofa-Diazo-a-(dialkoxyphosphoryl)acetamides and -acetates". European Journal of Organic Chemistry 2003 19 (2003): 3798-3810. http://dx.doi.org/10.1002/ejoc.200300330.
10.1002/ejoc.200300330
Norton Matos, Marta R. P.; Gois, Pedro M. P.; Mata, Maria L. E. N.; Cabrita, Eurico J.; Afonso, Carlos A. M.. "Studies on the Preparation of 4-Ethoxyalkyliden and 4-Aminoalkyliden-5(4H)-oxazolones". Synthetic Communications 33 8 (2003): 1285-1299. http://dx.doi.org/10.1081/scc-120018688.
10.1081/scc-120018688

Livro

Aguiar, S.; Dias, J.; Manuel, A.M.; Russo, R.; Gois, P.M.P.; da Silva, F.A.; Goncalves, J.. Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads. 2018.
10.1016/bs.apcsb.2018.03.002
Antonio, J.P.M.; Farias, G.D.V.; Santos, F.M.F.; Oliveira, R.; Cal, P.M.S.D.; Gois, P.M.P.. Boron-Nitrogen Bond: A Useful Molecular Construction Tool. 2016.
10.1002/9781119113874.ch2
Candeias, N.R.; Trindade, A.F.; Gois, P.M.P.; Afonso, C.A.M.. The Wolff Rearrangement. 2014.
10.1016/B978-0-08-097742-3.00325-6
Monteiro, C.M.; Trindade, A.F.; Gois, P.M.P.; Afonso, C.A.M.; Trindade, Alexandre F.; Gois, Pedro M. P.; Afonso, Carlos A. M.. Recyclable Stereoselective Catalysts. 2011.
10.1002/9781118087992.ch1

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2019/11/21	Exploring Boron Reagents for the Assembly of Functional Bioconjugates	11th PEGS Europe, Protein & Antibody Engineering Summit PEGS Europe (Lisboa, Portugal)
2019/10/23	Boron a Useful Element for Chemical Biology	Seminar – Chemistry Department University of Vienna University of Vienna (Vienna, Áustria)
2019/09/26	Boron a Useful Element for Chemical Biology	Seminar – Max Planck Institute for Polymer Research Max Planck Institute for Polymer Research (Mainz, Alemanha)
2019/01/16	Functional Linkers for Targeted Delivery	Seminar - Chimie Paristech PSL University Paristech PSL University (Paris, França)
2019/01/15	Functional Linkers for Targeted Delivery	ITN Protein Conjugates Winter School Institut Curie (Paris, França)
2018/07/20	Functional Linkers for Targeted Delivery	Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry Italian Chemical Society (Palermo, Itália)
2018/07/17	Iminoboronates: Functional Linkers for Targeted Delivery	Chemistry Department Seminars university degli studi milano university degli studi milano
2018/06/26	Functional Linkers for Targeted Delivery	16th Boron Chemistry Meeting in the Americas Boston College (Boston, Estados Unidos)
2018/03/20	Exploring iminoboronates in the assembly of reversible bioconjugates	255th ACS National Meeting ACS (New Orleans, Estados Unidos)
2017/07/24	Not that Boring: Boron a useful element for chemical biology	UCL - Department of Chemistry Seminars University College of London (London, Reino Unido)
2017/04/10	Make it Function - Playing with Reversibility	5ºENEQ Portuguese Chemical Society (Coimbra, Portugal)
2016/10	Iminoboronates: A useful construction tool for chemical biology	City college of New York, Chemistry Department Seminars City college of New York (New York City, Estados Unidos)
2015/09/02	Boronic acid: A useful building block for chemical biology	International Symposium on Synthesis and Catalysis Universidade de Évora (Évora, Portugal)
2015/03/01	B-N dative bond: A useful tool to modify proteins and to assemble tumor targeting conjugates	FloHet, GAINESVILLE Florida University (Florida, Estados Unidos)
2014/09/27	Boron based dynamic bonding: an emerging tool for synthesis and bioconjugation	CulturChem Seminars UPMC (Paris, França)
2014/09/19	Exploring dynamic bonds to modulate the activity and structure of proteins	iMed.ULisboa Seminars iMed.ULisboa (Lisboa, Portugal)
2014/09/19	Boron based dynamic bonding: an emerging construction tool for Chemical Biology	DEPARTMENT OF CHEMISTRY Seminars UNIVERSITY OF CAMBRIDGE
2014/05/14	Exploring Boronic Acids as a Construction Tool in Chemical biology	Huelva University Chemistry Department Seminars Huelva University (Huelva, Espanha)
2014/04/29	Boron based dynamic bonding: an emerging tool for Bioconjugation	4º PYCHEM Portuguese Chemical Society (Coimbra, Portugal)
2014/02/10	Unraveling Boron Based Biologics	JORTEC FCT/UNL (Almada, Portugal)
2013/06/14	Catalysts or ligands! The dual life of N-Heterocyclic Carbenes	Vicente Seabra's Award - SPQ Portuguese Chemical Society (Aveiro, Portugal)
2013/05/24	Mass Spectroscopy an invaluable tool to unravel the mechanism of action of N-B heterocycles	Seminario - Faculdade de Ciência da UL Faculdade de Ciência da UL (Lisboa, Portugal)
2013/05/17	Boron promoted assembly of new human neutrophile elastase inhibitors	1st Symposium on medicinal chemistry Minho University (Braga, Portugal)
2013/04/09	Boron promoted assembly of simple building blocks as an efficient strategy to modify proteins and discover biological active heterocycles	Portuguese Young Organic Chemist Award -SPQ Portuguese Chemical Society (Lisboa, Portugal)
2012/09/02	Metal-Organo multicatalysis: An emerging concept	XXV international Conference on organometallic Chemistry (XXV ICOMC) ICOMC (Lisboa, Portugal)
2012/07/12	Harnessing the N-B Bond as a Strategy to Modify Proteins and Assemble Heterocycles with a Natural Product-Like Framework	Organic Chemistry Symposium (6SPJ-OCS) - Eurojoc - Invited Plenary Portuguese Chemical Society (Lisboa, Portugal)
2012/07/12	Boron promoted assembly of simple building blocks as an efficient strategy to modify proteins and discover biological active heterocycles	ESOC ESOC (Marseille, França)
2012/03/12	Cooperative Metal-Organo Catalysis: An emerging Concept	Seminários do Instituto de Química, Universidade de Campinas Universidade de Campinas (Campinas, Brasil)
2012/03/12	NHCs: Catalysts and/or Ligands: The dual life of a molecule in Cooperative Metal-Organo Catalysis	Seminários do Instituto de Química, Universidade de São Paulo Universidade de São Paulo (São Paulo, Brasil)
2011/07/03	Cooperative Metal-Organo Catalysis: The Best of Two Worlds!	XXII Encontro Nacional da SPQ Portuguese Chemical Society (Braga, Portugal)
2010/01/29	Tuning the reactivity of Rhodium and Iron using N-Heterocyclic carbenes	Seminars and Colloquia at UCL Chemistry UCL Chemistry (London, Reino Unido)
2009/10/28	C-C and C-X bond formation using metal-catalysed processes and Multicomponent-Reactions	Seminários Científicos - Hovione e Universidades Hovione SA (Loures, Portugal)
2009/10/19	Towards molecular complexity: C-C bond formation in water using Metals and MCR	Flash Conference on Water Era Chemistry (Alemanha)
2009/07/16	Catalysis and MCRs useful approaches towards C-C and C-X bond formation	Young Investigator Workshop Chateau Liblice Czech Republic Euchems (Liblice, República Checa)
2008/04/02	A perfect structural match of NHC Ligands onto Rh dimers induces subtle reactivity: The efficient Alkylation of Aldehydes	Ciclo de conferencias do DQ-FCT/UNL DQ-FCT/UNL (Almada, Portugal)
2007/09/23	Axial coordination of NHC Rh dimers: A perfect structural match indices subtle reactivity	8º Encontro Nacional de Ctatálise e Materiais Porosos Portuguese Chemical Society (Lamego, Portugal)
2004/11/23	Dirhodium(II) Catalysed Intramolecular C-H Insertion on diazo-(diethoxyphosphoryl)acetamidas, an Expeditious way to prepare Heterocycles	TransMediterranean Colloquium on Heterocyclic Chemistry (TRAMECH 2004). (Marrahech, Marrocos)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2020/05/01 - 2024/05/01	Boron a Hot-Spot in the Periodic Table for Chemical Biology Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/01/01 - 2023/01/01	Development and Scale-Up of Peptide Drug Conjugates Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/01/01 - 2021/01/01	New bioconjugation strategies for selective cysteine functionalization Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/01/01 - 2021/01/01	Design of ROS Sensitive Traceless Linkers for Drug Delivery Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/01/01 - 2021/01/01	Targeted delivery of boronic acids through bioconjugation Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/01/01 - 2020/01/01	Cysteine Functionalization in the Synthesis of Complex and Well-Defined Bioconjugates Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/01/01 - 2020/01/01	Design of boronated multifunctional tumor-targeting drug conjugates Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/01/01 - 2019/01/01	Chemical site-selective functionalization of proteins with boronic acids Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/01/01 - 2018/01/01	Iminoboronates as useful scaffolds for tumor targeting Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/01/01 - 2017/01/01	3-Hydroxy-quinolin-2(1H)-ones, a useful scaffold: Synthesis and biological evaluation Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/01/01 - 2015/01/01	Síntese de ligandos bifuncionais quirais para o desenvolvimento de reacções multicomponente com catalisadores heterobimetálicos: Funcionalização de olefinas heteroaromáticas com potencial Atividade biológica Coorientador
2010/01/01 - 2014/01/01	NEW TOOLS FOR CHEMICAL MODIFICATION OF PROTEINS Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/01/01 - 2014/01/01	Boronic acids as partners in Multicomponent reactions Orientador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2006/01/01 - 2010/01/01	NHC-diRhodium (II) complexes Synthesis, Chracterization and catalytic evaluatiuon Coorientador de Alexandre Trindade	Universidade de Lisboa Instituto Superior Técnico, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2004/11/23 - 2004/11/27	TransMediterranean Colloquium on Heterocyclic Chemistry (TRAMECH 2004)	Marrahech, Marrocos

Distinções

Prémio

2023	Scientific Award in Chemistry and Chemical Engineering
2022	Pioneering Investigator 2022 by Chemical Communication Royal Society of Chemistry, Reino Unido
2013	Portuguese Young Organic Chemistry Award Sociedade Portuguesa de Química, Portugal
2013	Emerging Investigator 2014- Chemical Communications Royal Society of Chemistry, Reino Unido
2012	Vicente Seabra Medal (best chemist under 40) Sociedade Portuguesa de Química, Portugal
2008	Honor Mention - UTL Young Researcher Award Universidade de Lisboa Instituto Superior Técnico, Portugal
2001	School Merit Award Universidade Nova de Lisboa, Portugal

Título

2019	Coordinator of the SPQ division Chemistry for Life Sciences Sociedade Portuguesa de Bioquímica, Portugal

Outra distinção

2023	General Secretary (adjunct) Sociedade Portuguesa de Química, Portugal
2016	Vice presidente da divisão de química orgânica Sociedade Portuguesa de Química, Portugal
2014	President of the Portuguese Chemical Society Lisbon division Sociedade Portuguesa de Química, Portugal
2012	European Journal of Organic Chemistry plenary lecture at the 6SPJ
2012	2012 FCT Investigator - Development grant Fundação para a Ciência e a Tecnologia, Portugal
2009	Portuguese representative at the Young Investigator Workshop Sociedade Portuguesa de Química, Portugal