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Maria Vaz Pinto completed the Bachelor's degree in Biologia in 2017/06 by Universidade de Lisboa Faculdade de Ciências and Master's degree in Genética Molecular e Biomedicina in 2019/11 by Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia. She integrated a collaborative project between Fernandes' and Gois' labs with the primary goal of studying and characterizing demyelination using newly synthesized fluorescent molecules for the identification of demyelinating structures and glial cells, giving special attention to the microglia for their role in the progression of this pathological process. During this project, she worked with ex vivo organotypic slice cultures and primary cell cultures, evaluating demyelination, microglial phagocytosis and inflammatory pathways by immunohistochemistry, RT-qPCR, and confocal microscopy. At the same time acquired some level of expertise in chemical synthesis and fine-tuning of fluorescent molecules. Maria is currently working as a research fellow in Faculdade de Farmácia, Universidade de Lisboa, in the project Grant Multiple Sclerosis Innovation 2017, led by Professor Adelaide Fernandes. Her research focuses on microglia role in Multiple Sclerosis (MS), where she aims to find fluorescent chemical probes selective for microglia as an attempt to improve MS characterization, better define MS patient's prognosis, as well as to reduce neuroinflammation, promote remyelination and hopefully ameliorate MS pathology using targeting approaches to modulate these cells.
Identificação

Identificação pessoal

Nome completo
Maria Vaz Pinto

Nomes de citação

  • Maria V. Pinto
  • VazPinto, Maria

Identificadores de autor

Ciência ID
6D19-0C29-F7B6
ORCID iD
0000-0003-4972-7369

Endereços de correio eletrónico

  • mariagvp2009@gmail.com (Profissional)
  • mgv.pinto@campus.fct.unl.pt (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Genética e Hereditariedade
  • Ciências Exatas - Química - Química Orgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B2) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1) Utilizador independente (B2)
Formação
Grau Classificação
2017/09 - 2019/11
Concluído
Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"BASHY dyes for characterization of demyelination and possible microglia targeting" (TESE/DISSERTAÇÃO)
18
2014/09 - 2017/06
Concluído
Biologia (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Characterization and possible detection of the enzymes responsible for Saxitoxin biosynthesis in Synechococcus" (TESE/DISSERTAÇÃO)
15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2020/01/09 - 2021/12/31 Investigador (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09/03 - 2019/11/07 Estagiário de Investigação (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2022/01/01 - Atual PhD student Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Projetos

Bolsa

Designação Financiadores
2020/01/09 - 2021/07 Targeting multiple sclerosis immune- and psycho-pathophysiology by modulation of inflammation
GMSI2017
Bolseiro de Investigação
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Merck KGaA
Em curso
2018/09/01 - 2019/07/31 New molecules to characterize & treat demyelinating lesions
Grant for Young Investigator's Projects
Bolseiro de Mestrado
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Pinto, Maria V.; Santos, Fábio M. F.; Barros, Catarina; Ribeiro, Ana Rita; Pischel, Uwe; Gois, Pedro M. P.; Fernandes, Adelaide. "BASHY Dye Platform Enables the Fluorescence Bioimaging of Myelin Debris Phagocytosis by Microglia during Demyelination". Cells 10 11 (2021): 3163. http://dx.doi.org/10.3390/cells10113163.
    10.3390/cells10113163
  2. Maria J. S. A. Silva; Hélio Faustino; Jaime A. S. Coelho; Maria V. Pinto; Adelaide Fernandes; Ismael Compañón; Francisco Corzana; Gilles Gasser; Pedro M. P. Gois. "Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides". Angewandte Chemie 133 19 (2021): 10945-10952. https://doi.org/10.1002/ange.202016936.
    10.1002/ange.202016936
  3. José, Maria; Faustino, Hélio; Coelho, Jaime; VazPinto, Maria; Fernandes, Adelaide; companon, ismael; Corzana, Francisco; et al. "Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides". Angewandte Chemie International Edition (2021): http://dx.doi.org/10.1002/anie.202016936.
    Publicado • 10.1002/anie.202016936
  4. VazPinto, Maria (6D19-0C29-F7B6); Fernandes, Adelaide. "Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis". International Journal of Molecular Sciences 21 17 (2020): 5960. http://dx.doi.org/10.3390/ijms21175960.
    Publicado • 10.3390/ijms21175960
  5. Santos, Fábio M. F.; Domínguez, Zoe; Fernandes, João P. L.; Parente Carvalho, Cátia; Collado, Daniel; Pérez-Inestrosa, Ezequiel; VazPinto, Maria; et al. "Cyanine-Like Boronic Acid-Derived Salicylidenehydrazone Complexes (Cy-BASHY) for Bioimaging Applications". Chemistry – A European Journal 26 62 (2020): 14064-14069. http://dx.doi.org/10.1002/chem.202001623.
    Publicado • 10.1002/chem.202001623
Poster em conferência
  1. "BASHY dye: An improved fluorophore to image myelin removal by microglia in active lesions of Multiple Sclerosis". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience., 2021.
  2. "Bioimaging of Microglia and Myelin Clearance during demyelination Using the Fluorescent BASHY Platform.". Trabalho apresentado em Virtual European Glia Meeting 2021, 2021.
  3. "A Boronic Acid-based Fluorescent Complex for the imaging of myelin clearance by microglia in demyelinated lesions.". Trabalho apresentado em iMed.ULisboa Meeting 2021, 2021.
  4. VazPinto, Maria; Fábio M. F. Santos; Barateiro, Andreia; Brites, Dora; Pedro M. P. Gois; Fernandes, Adelaide. "BASHY dye as potential biomarker for demyelinating processes". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, 2019.
  5. VazPinto, Maria; Fábio M. F. Santos; Barateiro, Andreia; Brites, Dora; Pedro M. P. Gois; Fernandes, Adelaide. "Novel approach to characterize demyelination using newly synthesized BASHY molecules". Trabalho apresentado em 11th iMed.ULisboa Postgraduate students’ Meeting & 3rd i3DU Meeting, 2019.
  6. VazPinto, Maria; Fábio M. F. Santos; Barateiro, Andreia; Brites, Dora; Pedro M. P. Gois; Fernandes, Adelaide. "BASHY dyes: new attempt to characterize demyelination". Trabalho apresentado em IV Symposium of the Portuguese Glial Network, 2019.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/02/17 A new pharmacological approach to prevent synaptic loss and promote myelin phagocytosis: A step forward to modulate cognitive impairment and remyelination in MS. Portuguese Society of Pharmacology Meeting 2021
Faculdade de Farmácia da Universidade de Lisboa (Portugal)
2021/02/17 A new pharmacological approach to prevent synaptic loss and promote myelin phagocytosis: A step forward to modulate cognitive impairment and remyelination in MS. Portuguese Society of Pharmacology Meeting 2021
Faculdade de Farmácia da Universidade de Lisboa (Lisbon)
2019/11/12 BASHY dye as potential biomarker for demyelinating processes 5th Meeting of the Mind-Brain College
(Lisboa, Portugal)
2019/02/14 BASHY dyes: New attempt to characterize demyelination 8ª Edição das Jornadas Intercalares dos Mestrados do Departamento de Química (DQ) e do Departamento de Ciências da Vida (DCV)
(Almada, Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2019/03 - 2019/05/29 As a member of the organizing committee, I helped with the organization, the planning, and hosting of the IV Symposium of the Portuguese Glial Network, including being responsible for the venue, securing important sponsorships with several companies, and organizing all the logistics concerning the mobilization and accommodation of the participants. (2019/05/29 - 2019/05/29)
Simpósio (Membro da Comissão Organizadora)
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2021/04/14 - 2021/04/14 Lecture given about Amyotrophic Lateral Sclerosis. An overview on molecular mechanisms underlying the disease and ongoing research studies
Outro
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/07 - 2020/08 Participation in the online course of "Writing in the Sciences", organized by Kristin Sainani. Here, I learned how to improve my writing skills to become a more effective writer. This course addressed a variety of topics, namely the format of a scientific manuscript, peer review, grant writing, ethical issues in scientific publication, and writing for general audiences.
Outro
Stanford University Department of Statistics, Estados Unidos
2020/06/12 - 2020/07/12 Participation in the online course of "Fundamental Neuroscience for Neuroimaging", organized by Arnold Bakker. During this course I learned the basic principles of neuroimaging methods applied to human subjects research. In here, we addressed a variety of topics including the history of neuroimaging, neuroimaging physics and image formation and neuroimaging applications.
Outro
Johns Hopkins University, Estados Unidos
2020/04 - 2020/06 Member of the Volunteer team at research Institute for Medicines (iMed.ULisboa). During this period I was member of the iMed.ULisboa task force to help with the diagnosis of Covid-19, where I performed RT-qPCR analysis.
Outro
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Distinções

Outra distinção

2022 Travel Grant
The Company of Biologists Ltd, Reino Unido