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Manuela F. Frasco holds a degree in Biochemistry (2000) and a PhD in Biomedical Sciences (2007), both from the University of Porto. Currently (since 02/2023), she is an Invited Assistant Researcher at BioMark@UC, in the Department of Chemical Engineering (DEQ), at the Faculty of Sciences and Technology of the University of Coimbra (FCTUC). She has an h-index of 16 and 2198 citations (google scholar), 40 publications (30 of which are Scopus indexed), 1 patent registered, and over 60 oral/poster communications and invited talks/lectures. She is PI of a bilateral cooperation project Portugal-Germany (FCT funded) to develop photonic hydrogels to detect extracellular vesicles of neuronal origin and was Co-PI (defining the idea, writing and implementation) of the project STRIP2SENSE to develop photonic-based sensors for venous thromboembolism biomarkers (FCT funded). She was team member/researcher of 14 National and International Projects, and of 2 International Cooperation Projects Portugal-France and Portugal-Slovenia. She has been the supervisor of 5 PhD and 3 MSc theses, and of many undergraduate students and fellows of research projects. For the last 6 years, she established a new research line at the BioMark group dedicated to combine (i) bioinspired photonic materials and (ii) natural-based biopolymers and integrate them into optical biosensors applied to disease diagnosis and environmental monitoring. She is experienced in toxicology, enzymatic biomarkers, nanomaterials-based sensors, functionalization of materials with chemical/biological recognition elements (ionophores, aptamers, antibodies, biomimetic polymers), characterization of nanoconjugates and analytical validation of biosensors. She has also designed biocompatible and biodegradable polymeric nanocarriers for anticancer drug/gene delivery, including in vitro testing in cell cultures. Current scientific interests include stimuli-responsive polymers, photonic nanostructures, colloidal systems, biomimetic and bioinspired materials, and processing of natural-based biopolymers. She aims to harness these topics into innovative biosensors choosing greener materials and low-cost tools to increase the sustainability of the field.
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Identificação

Identificação pessoal

Nome completo
Manuela Maria Teixeira Basto de Faria Frasco

Nomes de citação

  • Frasco, Manuela F
  • Frasco, MF

Identificadores de autor

Ciência ID
421F-CD9B-986A
ORCID iD
0000-0002-1813-8089
Google Scholar ID
https://scholar.google.pt/citations?user=YY5J7QUAAAAJ&hl=en
Researcher Id
ABA-7709-2020
Scopus Author Id
9633427100

Endereços de correio eletrónico

  • mffrasco@uc.pt (Profissional)

Moradas

  • BioMark@UC, DEQ-FCTUC, University of Coimbra, Rua Sílvio Lima, Polo II, 3030-790, Coimbra, Coimbra, Portugal (Profissional)

Websites

  • https://biomark-uc.eu/ (Académico)

Domínios de atuação

  • Ciências da Engenharia e Tecnologias

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2007/04/23
Concluído
 Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000/11/15
Concluído
 Biochemistry (Licenciatura)
Especialização em Applied Biochemistry
Universidade do Porto Faculdade de Ciências, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/02/01 - Atual Investigador Auxiliar Convidado (carreira) (Investigação) Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
(...)
2023/06/07 - 2023/06/17 Investigador visitante (Investigação) VTT Technical Research Centre of Finland Ltd, Finlândia
2020/02/01 - 2023/01/31 Pós-doutorado (Investigação) Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
(...)
2015/10/19 - 2019/12/31 Investigador Auxiliar Convidado (carreira) (Investigação) Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
2014/12/01 - 2015/06/30 Pós-doutorado (Investigação) Universidade do Minho, Portugal
Biomaterials Biodegradables and Biomimetics, Portugal
2011/03/01 - 2014/02/28 Pós-doutorado (Investigação) Universidade do Porto Faculdade de Engenharia, Portugal
2012/10/04 - 2013/03/31 Investigador visitante (Investigação) Oslo Universitetssykehus, Noruega
2010/03/01 - 2011/02/28 Pós-doutorado (Investigação) Universidade de Lisboa Instituto Superior Técnico, Portugal
2008/03/01 - 2010/02/28 Pós-doutorado (Investigação) University of Crete, Department of Chemistry, Grécia
2006 - 2007 Investigador visitante (Investigação) Univerza v Ljubljani Medicinska Fakulteta, Eslovénia
2004 - 2007 Investigador visitante (Investigação) Institut de Pharmacologie et de Biologie Structurale, França
2001/06/01 - 2006/07/31 Investigador (Investigação) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Projetos

Bolsa

Designação Financiadores
2008/03/01 - 2014/02/28 Development of nanomaterials-based sensors and therapeutic delivery vehicles
SFRH/BPD/40876/2007
Bolseiro de Pós-Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
2012/10/04 - 2013/03/31 Combined effect of anti-miRNAs delivered by nanoparticles and ionizing radiation on cancer cells
219872/F11; SFRH/BPD/40876/2007
Bolseiro de Pós-Doutoramento
Norges forskningsråd

Fundação para a Ciência e a Tecnologia
Concluído
2002/08/01 - 2006/07/31 Effects of environmental contaminants on the cholinesterasic function of one estuarine species (Palaemon serratus)
SFRH/BD/6826/2001
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2023/04/04 - Atual Photonic hydrogels to detect extracellular vesicles of neuronal origin
FCT-DAAD 2023/2024
Investigador responsável
Em curso
2017/10/16 - 2020/01/16 Test strips for biomarker screening of venous thromboembolism in oncology
SAICT-POL/24358/2016 | NORTE-01-0145-FEDER-024358
Co-Investigador Responsável (Co-IR)
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

International Iberian Nanotechnology Laboratory, Portugal
Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluído
Produções

Publicações

Artigo em conferência
  1. Ramalho MJ, Loureiro JA, Gomes B, Frasco MF, Coelho MAN, Pereira MC. "PLGA nanoparticles for calcitriol delivery". 2015.
    10.1109/ENBENG.2015.7088884
  2. Frasco MF, Rocha S, Pereira MC, Coelho MAN. "Preparation and characterization of PLGA nanoparticles as anticancer drug delivery carriers". 2012.
  3. Martins SAM, Martins VC, Frasco MTBF, Freitas PP, Fonseca LP. "Magnetic labeling of waterborne pathogens towards a magnetoresistive-based biochip". 2010.
  4. Frasco MF, Chaniotakis NA. "CdSe quantum dots - Calix[4]crown-5 nanoassembly for ion sensing". 2009.
    10.1109/SMICND.2009.5336603
  5. Frasco MF, Buiculescu R, Vamvakaki V, Chaniotakis NA. "The applications of carbon nanostructures and semiconductor materials in the development of biosensors". 2009.
    10.1109/SMICND.2009.5336595
  6. Moreira SM, Frasco MF, Carvalho F, Ribeiro R, Guilhermino L. "Environmental biomarkers in two estuarine invertebrates: Hediste diversicolor and Palaemon serratus". Trabalho apresentado em Journal of Veterinary Pharmacology and Therapeutics, 2003.
    10.1046/j.1365-2885.25.s1.1.x
  7. Frasco MF, Moreira SM, Ribeiro R, Carvalho F, Guilhermino L. "Biochemical characterization of cholinesterases from Palaemon serratus (Arthropoda: Crustacea) and Hediste diversicolor (Annelida: Polychaeta)". Trabalho apresentado em Journal of Veterinary Pharmacology and Therapeutics, 2003.
    10.1046/j.1365-2885.25.s1.1.x
Artigo em revista
  1. Resende S, Fernandes J, Sousa PC, Calaza C, Frasco MF, Freitas PP, Sales MGF. "Fabrication and sensing properties of a molecularly imprinted polymer on a photonic PDMS substrate for the optical detection of C-reactive protein". Chemical Engineering Journal (2024): 149924. http://dx.doi.org/10.1016/j.cej.2024.149924.
    10.1016/j.cej.2024.149924
  2. Mateus D, Sebastião AI, Frasco MF, Carrascal MA, Falcão A, Gomes CM, Neves B, Sales MGF, Cruz MT. "Artificial Dendritic Cells: A New Era of Promising Antitumor Immunotherapy". Small 19 46 (2023): http://dx.doi.org/10.1002/smll.202303940.
    10.1002/smll.202303940
  3. Suleimenova A, Frasco MF, Soares da Silva FAG, Gama M, Fortunato E, Sales MGF. "Bacterial nanocellulose membrane as novel substrate for biomimetic structural color materials: Application to lysozyme sensing". Biosensors and Bioelectronics: X 13 (2023): 100310. http://dx.doi.org/10.1016/j.biosx.2023.100310.
    10.1016/j.biosx.2023.100310
  4. Resende S, Frasco MF, Freitas PP, Sales MGF. "Detection of serum calprotectin based on molecularly imprinted photonic hydrogels: A novel approach for IBD diagnosis". Biosensors and Bioelectronics: X 13 (2023): 100313. http://dx.doi.org/10.1016/j.biosx.2023.100313.
    10.1016/j.biosx.2023.100313
  5. Cardoso AR, Alves JF, Frasco MF, Piloto AM, Serrano V, Mateus D, Sebastião AI, Matos AM, Carmo A, Cruz T, Fortunato E, S. "An ultra-sensitive electrochemical biosensor using the Spike protein for capturing antibodies against SARS-CoV-2 in point-of-care". Materials Today Bio 16 (2022): 100354. http://dx.doi.org/10.1016/j.mtbio.2022.100354.
    Acesso aberto • 10.1016/j.mtbio.2022.100354
  6. Pereira CF, Sales MGF, Frasco MF. "A molecularly imprinted photonic polymer based on an inverse opal structure for sensing D-dimer at the point-of-care". Talanta 243 (2022): 123387. http://dx.doi.org/10.1016/j.talanta.2022.123387.
    Acesso aberto • 10.1016/j.talanta.2022.123387
  7. Vaz R, Serrano VM, Castaño-Guerrero Y, Cardoso AR, Frasco MF, Sales MGF. "Breaking the classics: Next-generation biosensors for the isolation, profiling and detection of extracellular vesicles". Biosensors and Bioelectronics: X 10 (2022): 100115. http://dx.doi.org/10.1016/j.biosx.2022.100115.
    Acesso aberto • 10.1016/j.biosx.2022.100115
  8. Amorim MS, Sales MGF, Frasco MF. "Recent advances in virus imprinted polymers". Biosensors and Bioelectronics: X (2022): 100131. http://dx.doi.org/10.1016/j.biosx.2022.100131.
    Acesso aberto • 10.1016/j.biosx.2022.100131
  9. Vaz R, Valpradinhos B, Frasco MF, Sales MGF. "Emerging Optical Materials in Sensing and Discovery of Bioactive Compounds". Sensors 21 17 (2021): 5784. http://dx.doi.org/10.3390/s21175784.
    10.3390/s21175784
  10. Miguéis SdC, Tavares APM, Martins GV, Frasco MF, Sales MGF. "Biosensors for European Zoonotic Agents: A Current Portuguese Perspective". Sensors 21 13 (2021): 4547. http://dx.doi.org/10.3390/s21134547.
    10.3390/s21134547
  11. Cardoso AR, Frasco MF, Serrano V, Fortunato E, Sales MGF. "Molecular Imprinting on Nanozymes for Sensing Applications". Biosensors 11 5 (2021): 152. http://dx.doi.org/10.3390/bios11050152.
    10.3390/bios11050152
  12. Resende S, Frasco MF, Sales MGF. "A biomimetic photonic crystal sensor for label-free detection of urinary venous thromboembolism biomarker". Sensors and Actuators B: Chemical 312 (2020): 127947. http://dx.doi.org/10.1016/j.snb.2020.127947.
    10.1016/j.snb.2020.127947
  13. Vaz R, Frasco MF, Sales MGF. "Photonics in nature and bioinspired designs: sustainable approaches for a colourful world". Nanoscale Advances (2020): http://dx.doi.org/10.1039/d0na00445f.
    10.1039/d0na00445f
  14. Frasco MF, Truta LAANA, Sales MGF, Moreira FTC. "Imprinting Technology in Electrochemical Biomimetic Sensors". Sensors 17 3 (2017): 523. http://dx.doi.org/10.3390/s17030523.
    10.3390/s17030523
  15. Ramalho MJ, Loureiro JA, Gomes B, Frasco MF, Coelho MAN, Pereira MC. "PLGA nanoparticles as a platform for vitamin D-based cancer therapy". Beilstein Journal of Nanotechnology 6 (2015): 1306-1318. http://dx.doi.org/10.3762/bjnano.6.135.
    10.3762/bjnano.6.135
  16. Frasco MF, Almeida GM, Santos-Silva F, Pereira MC, Coelho MAN. "Transferrin surface-modified PLGA nanoparticles-mediated delivery of a proteasome inhibitor to human pancreatic cancer cells". Journal of Biomedical Materials Research Part A 103 4 (2014): 1476-1484. http://dx.doi.org/10.1002/jbm.a.35286.
    10.1002/jbm.a.35286
  17. Frasco MF, Eržen I, Stojan J, Guilhermino L. "Localization and properties of cholinesterases in the common prawn (Palaemon serratus): A Kinetic-histochemical study". Biological Bulletin 218 1 (2010): 1-5. http://www.biolbull.org/content/218/1/1.full.
  18. Frasco MF, Chaniotakis NA. "Semiconductor Quantum Dots in Chemical Sensors and Biosensors". Sensors 9 9 (2009): 7266-7286. http://dx.doi.org/10.3390/s90907266.
    10.3390/s90907266
  19. Frasco MF, Chaniotakis N. "Bioconjugated quantum dots as fluorescent probes for bioanalytical applications". Analytical and Bioanalytical Chemistry 396 1 (2009): 229-240. http://dx.doi.org/10.1007/s00216-009-3033-0.
    10.1007/s00216-009-3033-0
  20. Frasco MF, Vamvakaki V, Chaniotakis N. "Porphyrin decorated CdSe quantum dots for direct fluorescent sensing of metal ions". Journal of Nanoparticle Research 12 4 (2009): 1449-1458. http://dx.doi.org/10.1007/s11051-009-9714-y.
    10.1007/s11051-009-9714-y
  21. Frasco MF, Fournier D, Carvalho F, Guilhermino L. "Does mercury interact with the inhibitory effect of dichlorvos on Palaemon serratus (Crustacea: Decapoda) cholinesterase?". Science of The Total Environment 404 1 (2008): 88-93. http://dx.doi.org/10.1016/j.scitotenv.2008.06.012.
    10.1016/j.scitotenv.2008.06.012
  22. Vieira LR, Sousa A, Frasco MF, Lima I, Morgado F, Guilhermino L. "Acute effects of Benzo[a]pyrene, anthracene and a fuel oil on biomarkers of the common goby Pomatoschistus microps (Teleostei, Gobiidae)". Science of The Total Environment 395 2-3 (2008): 87-100. http://dx.doi.org/10.1016/j.scitotenv.2008.01.052.
    10.1016/j.scitotenv.2008.01.052
  23. Frasco MF, Colletier J-P, Weik M, Carvalho F, Guilhermino L, Stojan J, Fournier D. "Mechanisms of cholinesterase inhibition by inorganic mercury". FEBS Journal 274 7 (2007): 1849-1861. http://dx.doi.org/10.1111/j.1742-4658.2007.05732.x.
    10.1111/j.1742-4658.2007.05732.x
  24. Frasco MF, Fournier D, Carvalho F, Guilhermino L. "Cholinesterase from the common prawn (Palaemon serratus) eyes: Catalytic properties and sensitivity to organophosphate and carbamate compounds". Aquatic Toxicology 77 4 (2006): 412-421. http://dx.doi.org/10.1016/j.aquatox.2006.01.011.
    10.1016/j.aquatox.2006.01.011
  25. Frasco MF, Fournier D, Carvalho F, Guilhermino L. "Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity". Biomarkers 10 5 (2005): 360-375. http://dx.doi.org/10.1080/13547500500264660.
    10.1080/13547500500264660
  26. Frasco MF, Guilhermino L. "Effects of dimethoate and beta-naphthoflavone on selected biomarkers of Poecilia reticulata". Fish Physiology and Biochemistry 26 2 (2002): 149-156. https://doi.org/10.1023/A:1025457831923.
    10.1023/A:1025457831923
Capítulo de livro
  1. Vaz R, Frasco MF, Sales MGF. "Biosensors: concept and importance in point-of-care disease diagnosis". In Biosensor Based Advanced Cancer Diagnostics: From Lab to Clinics, 59-84. Elsevier, 2022.
    10.1016/b978-0-12-823424-2.00001-6
  2. Frasco MF, Moreira FTC, Martins G, Castaño-Guerrero Y, Carneiro MCCG, da Rocha L, Pereira-Cameselle R, Ozcelik A; Bolaño S, Alonso-Gómez JL, Riveiro A, Chiussi S, Oliveira AL, Sousa-Castillo A, Correa-Duarte MA, Sales MGF. "Innovative sensors for age-related diseases". 33-41. 2020.
    10.5281/ZENODO.3958933
  3. Moreira FTC, Frasco MF, Barbosa SG, Peixoto L, Alves MM, Sales MGF. "Enzymatic self-powered biosensing devices". In Bioelectrochemical Interface Engineering, 505-519. 2019.
    10.1002/9781119611103.ch25
Poster em conferência
  1. Martins JR, Sales MGF, Frasco MF. "Protein-based photonic hydrogel for sensing microRNAs". Trabalho apresentado em I International Meeting Molecules 4 Life, UTAD, Vila Real, Portugal, abstract book p. 114, 2023.
  2. Martins RM, Frasco MF, Mendes AM, Sales MGF. "Synthesis and application of carbon dots as electrochemical performance enhancers in homemade screen-printed electrodes". Trabalho apresentado em XXV Meeting of the Portuguese Electrochemical Society, Coimbra, Portugal, abstract book p. 60, 2023.
  3. Cardoso AR, Alves JF, Frasco MF, Sales MGF. "Biographene for electrochemical applications". Trabalho apresentado em XXV Meeting of the Portuguese Electrochemical Society, Coimbra, Portugal, abstract book p. 68, 2023.
  4. Suleimenova A, Tay DMY, Frasco MF, Sales MGF, Sikes HD. "Comparative study of the performance of plastic antibodies with thermostable engineered affinity proteins for biosensing applications". Trabalho apresentado em ACS Fall 2023 - Harnessing the Power of Data, San Francisco, USA, 2023.
  5. Suleimenova A, Cardoso AR, Moreira FCT, Frasco MF, Sales MGF. "Simple and low-cost probe-free electrochemical biosensor for monitoring microRNA-21-5p". Trabalho apresentado em ACS Fall 2023 - Harnessing the Power of Data, San Francisco, USA, 2023.
  6. Vaz R, Sales MGF, Frasco MF. "Photonic core-shell molecularly imprinted materials for sensing cancer-related extracellular vesicles". Trabalho apresentado em 2nd Meeting of the Portuguese Network on Extracellular Vesicles, NOVA Medical School, Lisboa, Portugal, abstract book p. 40, 2023.
  7. Alves JF, Sales MGF, Frasco MF. "Photonic hydrogels based on TiO2 inverse opal for rosiglitazone sensing". Trabalho apresentado em 9th Iberian Meeting on Colloids and Interfaces (RICI9), Santiago de Compostela, Spain, abstract book p. 113, 2022.
  8. Vaz R, Sales MGF, Frasco MF. "Molecularly imprinted photonic hydrogels for extracellular vesicles detection". Trabalho apresentado em Encontro Ciência FCT 2022, Lisboa, Portugal, 2022.
  9. Amorim MS, Frasco MF, Sales MGF. "Molecularly imprinted hydrogel-based photonic sensor: application to the detection of extracellular vesicles". Trabalho apresentado em ChemBioGels 2021 - Advances in hydrogels for biomedical applications-online, University of Minho, abstract book p. 53, 2021.
  10. Suleimenova A, Frasco MF, Soares-da-Silva FGF, Gama M, Fortunato E, Sales MGF. "Photonic SiO2@PDA molecularly imprinted polymer-based platform for biosensing applications". Trabalho apresentado em 31st Anniversary World Congress on Biosensors - Biosensors 2021-online, 2021.
  11. Resende S, Frasco MF, Freitas PP, Sales MGF. "Novel molecularly imprinted photonic sensors applied to IBD detection". Trabalho apresentado em Encontro Ciência FCT 2021-online, 2021.
  12. Vaz R, Frasco MF, Sales MGF. "Bioinspired photonic polymeric sensors for analysing exosomes". Trabalho apresentado em Encontro Ciência FCT 2021-online, 2021.
  13. Suleimenova A, Frasco MF, Fortunato E, Sales MGF. "Nanomaterials and biosensors for health applications". Trabalho apresentado em Encontro Ciência FCT 2021-online, 2021.
  14. Suleimenova A, Marques AC, Fernandes T, Frasco MF, Fortunato E, Sales MGF. "Molecular imprinting-based sensor with dual transduction: electrochemical and optical". Trabalho apresentado em MIT Portugal 2019 Annual Conference, Açores, Portugal, 2019.
  15. Frasco MF, Pereira-Cameselle R, Chiussi S, Alonso-Gómez JL, Sales MGF. "Molecularly imprinted chiroptical sensor for detection of glucose". Trabalho apresentado em 1st International Conference on Nanotechnologies and Bionanoscience, Heraklion, Crete, Greece, abstract book p. 254, 2018.
  16. Frasco MF, Piloto AM, Sales MGF. "Molecularly imprinted stimuli-responsive polymer nanoparticles using magnetically recoverable templates". Trabalho apresentado em nanoPT2016 International Conference, Braga, Portugal, abstract book p. 170-171, 2016.
  17. Hora C, Truta LAANA, Tavares APM, Frasco MF, Piloto AM, Sales MGF. "Integrating biosensors in photovoltaic cells: the 3P's project". Trabalho apresentado em iBEM - 1st International IPP Biomedical Engineering Meeting, Porto, Portugal, 2016.
  18. Piloto AM, Frasco MF, Rodrigues SSM, Ribeiro DSM, Santos JLM, Sales MGF. "Myoglobin imprinted polymer on CdTeMPA quantum dots as a fluorescent biosensor". Trabalho apresentado em 26th World Congress on Biosensors, Gothenburg, Sweden, 2016.
  19. Frasco MF, Eržen I, Stojan J, Guilhermino L. "Localization and properties of cholinesterases in the common prawn (Palaemon serratus): a kinetic-histochemical study". Trabalho apresentado em 7th Iberian and 4th Iberoamerican Congress of Environmental Contamination and Toxicology, Lisboa, Portugal, abstract book p. 116, 2008.
  20. Frasco MF, Stojan, J, Fournier D, Carvalho F, Guilhermino L. "Effects of environmental contaminants on common prawn (Palaemon serratus) cholinesterase activity". Trabalho apresentado em 17th Annual Meeting of SETAC Europe, Porto, Portugal, abstract book p. 236-237, 2007.
  21. Sousa A, Vieira LR, Frasco MF, Lima I, Morgado F, Guilhermino L. "Effects of two polycyclic aromatic hydrocarbons on biomarkers of the common goby Pomatoschistus microps". Trabalho apresentado em 16th Annual Meeting of SETAC Europe, The Hague, The Netherlands, abstract book p. 269, 2006.
  22. Frasco MF, Fournier D, Stojan J, Carvalho F, Guilhermino L. "In vitro inhibitory effect of metals on cholinesterase activity from various species". Trabalho apresentado em 16th Annual Meeting of SETAC Europe, The Hague, The Netherlands, abstract book p. 267, 2006.
  23. Frasco MF, Fournier D, Stojan J, Carvalho F, Guilhermino L. "Inhibition of cholinesterases by metals". Trabalho apresentado em IV Meeting CIMAR-Associate Laboratory”, Peniche, Portugal, 2006.
  24. Frasco MF, Fournier D, Carvalho F, Guilhermino L. "Prawn (Palaemon serratus) cholinesterase activity as a potential biomarker". Trabalho apresentado em 12th International Symposium on Toxicity Assessment, Skiathos, Greece, proceedings book p. 29, 2005.
  25. Vieira LR, Sousa A, Frasco MF, Lima I, Morgado F, Guilhermino L. "Effects of polycyclic aromatic hydrocarbons on biomarkers of the common goby Pomatoschistus microps". Trabalho apresentado em 6th Iberian and 3rd Iberoamerican Congress of Environmental Contamination and Toxicology, Cadiz, Spain, abstract book p. 164, 2005.
  26. Frasco MF, Fournier D, Stojan J, Carvalho F, Guilhermino L. "Evidence for cholinesterases inhibition by metals occurring as environmental contaminants". Trabalho apresentado em VIII International Meeting on Cholinesterases, Perugia, Italy, abstract book p. 19, 2004.
  27. Frasco MF, Guilhermino L. "Enzymatic biomarkers to assess xenobiotic toxicity to Poecilia reticulata". Trabalho apresentado em BIOMARKERS 2001 - Biomarkers of Environmental Contamination, Póvoa de Varzim, Portugal, abstract book p. 98, 2001.
  28. Castro BB, Frasco MF, Pereira A, Guilhermino L. "Ecotoxicological use of a battery of enzymatic biomarkers in guppy (Poecilia reticulata)". Trabalho apresentado em 11th Annual Meeting of SETAC Europe, Madrid, Spain, abstract book p. 230, 2001.
Recurso online
  1. Colletier J-P, Frasco MF, Carvalho F, Guilhermino L, Stojan J, Fournier D, Weik M. Structure of human butyrylcholinesterase in complex with 10 mM HgCl2 (Protein Data Bank entry). 2007. http://www.rcsb.org/pdb/explore/explore.do?structureId=2J4C.
    10.2210/pdb2j4c/pdb
Resumo em conferência
  1. Neves D, Sales MGF, Frasco MF. "Biomimetic hydrogel for optical sensing of extracellular vesicles". Trabalho apresentado em I International Meeting Molecules 4 Life, UTAD, Vila Real, Portugal, abstract book p. 65, 2023.
  2. Frasco MF, Amorim MS, Pires JF, Sales MGF.. "Plastic antibodies tailored as photonic materials for sensing extracellular vesicles.". Trabalho apresentado em ISEV2022 Abstract Book, Journal of Extracellular Vesicles, Lyon, France, 2022.
    10.1002/jev2.12224
  3. Vaz R, Freitas N, Sales MGF, Frasco MF. "Biocompatible photonic hydrogels for the isolation and detection of extracellular vesicles.". Trabalho apresentado em ISEV2022 Abstract Book, Journal of Extracellular Vesicles, Lyon, France, 2022.
    10.1002/jev2.12224
  4. Martins JR, Sales MGF, Frasco MF. "Photonic protein-based hydrogels for sensing applications". Trabalho apresentado em 9th Iberian Meeting on Colloids and Interfaces (RICI9), Santiago de Compostela, Spain, abstract book p. 34, 2022.
  5. Suleimenova A, Frasco MF, Fortunato E, Sales MGF. "Paper-based SERS sensor for detection of nucleolin". Trabalho apresentado em 9th Iberian Meeting on Colloids and Interfaces (RICI9), Santiago de Compostela, Spain, abstract book p. 79, 2022.
  6. Resende S, Frasco MF, Sales MGF. "Label-free colorimetric detection of calprotectin using photonic crystals-based sensor and molecular imprinting technology". Trabalho apresentado em 31st World Congress on Biosensors - Biosensors 2021-online, 2021.
  7. Vaz R, Sales MGF Frasco MF. "Nature-inspired photonic sensor for microRNAs in cancer-associated extracellular vesicles". Trabalho apresentado em First Meeting of the Portuguese Network on Extracellular Vesicles (PNEV), i3S, Porto, Portugal, abstract book p. 48, 2021.
  8. Vaz R, Sales MGF, Frasco MF. "Nanophotonic platform for cancer-associated exosomal microRNA detection". Trabalho apresentado em ISEV2020 Abstract Book, Journal of Extracellular Vesicles, ISEV2020-online, 2020.
    10.1080/20013078.2020.1784511
  9. Vaz R, Cunha AC, Sales MGF, Frasco MF. "Biopolymeric photonic sensing of cancer protein biomarkers". Trabalho apresentado em 8th Iberian Meeting on Colloids and Interfaces (RICI8), Aveiro, Portugal, abstract book p. 79, 2019.
  10. Suleimenova A, Marques AC, Fernandes T, Sales MGF, Fortunato E, Frasco MF. "Transparent electrodes for optical and electrochemical biosensor applications". Trabalho apresentado em 8th Iberian Meeting on Colloids and Interfaces (RICI8), Aveiro, Portugal, abstract book p. 67, 2019.
  11. Resende S, Frasco MF, Sales MGF. "Opal photonic crystal-based molecularly imprinted sensor for detection of a venous thromboembolism biomarker". Trabalho apresentado em 8th Graduate Student Symposium on Molecular Imprinting 2019, Berlin, Germany, abstract book p. 38, 2019.
  12. Resende S, Frasco MF, Sales MGF. "Photonic crystal-based sensor for label-free detection of fibrinopeptide B". Trabalho apresentado em 1st International Conference on Nanotechnologies and Bionanoscience, Heraklion, Crete, Greece, abstract book p. 137, 2018.
  13. Pereira CF, Frasco MF, Sales MGF. "Towards an unprecedented molecularly imprinted photonic biosensor for venous thromboembolism". Trabalho apresentado em 1st International Conference on Nanotechnologies and Bionanoscience, Heraklion, Crete, Greece, abstract book p. 71, 2018.
  14. Frasco MF, Pereira CF, Resende S, Sales MGF. "Molecularly imprinted photonic sensor for detection of cancer biomarkers". Trabalho apresentado em 1st International Conference on Nanotechnologies and Bionanoscience, Heraklion, Crete, Greece, abstract book p. 70, 2018.
  15. Oliveira M, Frasco MF, Sales MGF. "Plastic antibodies on a paper-based sensor applied to cancer detection". Trabalho apresentado em 2017 EMN Meeting on Biomaterials, Milan, Italy, abstract book p. 60, 2017.
  16. Frasco MF, Carvalho F, Guilhermino L, Stojan J, Fournier D. "Cholinesterase enzymes: Appraisal of inhibitory mechanisms for their use as an environmental biomarker of toxicity". Trabalho apresentado em 14th International Symposium Pollutant Responses in Marine Organisms (PRiMO), Florianópolis, Brazil, 2008.
    10.1016/j.marenvres.2008.02.017
  17. Frasco MF, Carvalho F, Guilhermino L, Stojan J, Fournier D. "Putative mechanisms underlying the inhibition of cholinesterases by inorganic mercury". Trabalho apresentado em 9th International Symposium on Metal Ions in Biology and Medicine, Lisboa, Portugal, abstract book p. 73, 2006.
Tese / Dissertação
  1. Frasco, Manuela F. "Effects of environmental contaminants on the cholinesterasic function of one estuarine species (Palaemon serratus)". Doutoramento, Universidade do Porto, 2007.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023 Engineered functional photonic materials for bioinspired sensing I International Meeting Molecules 4 Life, abstract book p.64
UTAD (Vila real, Portugal)
2022 Bioinspired materials for innovative devices - applications in the context of the CY-Sensors project Jornadas Upgrade UC Team
FCTUC (Coimbra, Portugal)
2022 Photonic biosensors - Bioinspired materials for innovative biomedical devices Prodeq20 - 20 anos ao serviço da Engenharia Química
DEQ-FCTUC (Coimbra, Portugal)
2019 Nanostructured molecularly imprinted sensors for point-of-care testing VII Scientific Meeting of IBEROS
(Guimarães, Portugal)
2018 Photonic crystal-based sensor for detecting venous thromboembolism biomarkers III Scientific Meeting of IBEROS
(Porto, Portugal)
2017 Sensors for ageing-associated diseases based on molecular imprinting technology II Scientific Meeting of IBEROS
(A Coruna, Espanha)
2017 Biomimetic materials for sensing cancer biomarkers 2017 EMN Meeting on Biomaterials
(Milan, Itália)
2015 Nanotechnology meets biomedicine: diagnostic, therapeutic and tissue engineering applications
Universidade do Minho, 3B's Research Group (Guimarães, Portugal)
2005 The challenges of using acetylcholinesterase as an environmental biomarker
Universidade do Porto, CIIMAR (Porto, Portugal)
2001 In vivo effects of beta-naphthoflavone on cytochrome P450 and other enzymatic systems of Poecilia reticulata
Universidade do Porto, CIIMAR (Porto, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/02/16 - Atual Production of nanomaterials and optimization of new sensing substrates for space applications
Coorientador
 Biomedical Engineering Project - Bachelor in Biomedical Engineering (Outra)
Universidade de Coimbra, Portugal
2024/02/15 - Atual Development of synthetic vesicles for optical biosensing
Orientador
 Chemical Engineering (Mestrado)
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2024/01/01 - Atual Smart hydrogels for live cell-based sensing devices
Orientador
 Chemical Engineering (Doutoramento)
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2024/01/01 - Atual Biomimetic hydrogels for optical sensing of extracellular vesicles
Orientador
 Biosciences – specialization in Biotechnology (Doutoramento)
2021/01/01 - Atual Lab-on-leaf: bioinspired photonic polymer sensors on natural microfluidics for analysing exosomes
Orientador
 Chemical Engineering (Doutoramento)
Universidade de Coimbra, Portugal
2019/02/01 - Atual Novel molecularly imprinted photonic sensors applied to inflammatory bowel diseases
Coorientador
 Biomedical Engineering (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/01/01 - Atual Nanomaterials and biosensors for health applications
Coorientador
 Bioengineering Systems (MIT Portugal Program) (Doutoramento)
Universidade Nova de Lisboa, Portugal
2022/02/22 - 2033/02/24 Photonic protein-based hydrogel for sensing microRNAs in extracellular vesicles
Orientador
 Chemical Engineering (Mestrado)
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2023/03/01 - 2023/07/31 Development of an optical biosensor for glucose detection
Orientador
 Internship - Bachelor in Bioengineering (Biological Engineering branch) (Outra)
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal

Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
2023/02/06 - 2023/06/30 Elastomeric polymer with structural colors for biomedical applications
Orientador
 Biomedical Engineering Project - Bachelor in Biomedical Engineering (Outra)
Universidade de Coimbra, Portugal
2023/02/06 - 2023/06/30 Inverse opal photonic hydrogels for biosensor development
Orientador
 Biomedical Engineering Project - Bachelor in Biomedical Engineering (Outra)
Universidade de Coimbra, Portugal
2022/02/07 - 2022/07/14 Development of photonic polymer materials for biosensors
Orientador
 Biomedical Engineering Project - Bachelor in Biomedical Engineering (Outra)
Universidade de Coimbra, Portugal
2021/01/25 - 2022/02/21 Development of a biosensor based on plastic antibodies for the isolation and detection of extracellular vesicles
Orientador
 Biological Engineering (Mestrado)
Universidade do Minho Centro de Engenharia Biológica, Portugal
2019/01/15 - 2019/07/31 Application of new photonic materials in the development of biosensors
Orientador
 Internship Outclass (Bachelor in Bioengineering) (Iniciação científica)
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
2019/05/20 - 2019/07/26 Development of new molecularly imprinted photonic materials
Orientador
 International Internship for DUT in Chemistry (IUT D'Orsay, Université Paris Sud) (Outra)
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018 - 2018 Member of the Organizing Committee - "III Scientific Meeting of IBEROS project", Porto, Portugal, 19 Mar'18 (2018/03/19 - 2018/03/19)
Simpósio (Membro da Comissão Organizadora)
2017 - 2017 Assistant to the Organizing Committee - 7th Graduate Student Symposium on Molecular Imprinting, Porto, Portugal, 8-9 Jun'17 (2017/06/08 - 2017/06/09)
Simpósio (Outra)
2007 - 2007 Assistant to the Organizing Committee - 17th Annual Meeting of Society of Environmental Toxicology and Chemistry (SETAC) Europe, Porto, Portugal, 20-24 May'07 (2007/05/20 - 2007/05/24)
Conferência (Outra)
2001 - 2001 Assistant to the Organizing Committee - BIOMARKERS 2001 - Biomarkers of Environmental Contamination, Póvoa de Varzim, Portugal, 24-26 Sep'01 (2001/09/24 - 2001/09/26)
Conferência (Outra)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2019/11/06 - 2019/11/06 Symposium Session Chair - Head of table "Topic 2: Applications of EVs: biomedical use, nutraceutics, cosmetics", 1st Clustering event for extracellular vesicles FET-Open projects
Simpósio
 1st Clustering event for extracellular vesicles FET-Open projects, Palermo, Italy, 6 Nov’19
2017/09/24 - 2017/09/30 Member of a finalist team of SPLASH Innovation competition - UPTEC Acceleration Programme and Communication Workshop, Porto Water Innovation Week, Porto, Portugal, 2017
Oficina (workshop)
 Porto Water Innovation Week, Porto, Portugal, 2017
2017/08/17 - 2017/08/17 Conference Session Chair - "Biomedical Application III", 2017 EMN Meeting on Biomaterials
Conferência
 2017 EMN Meeting on Biomaterials, Milan, Italy, 14-18 Aug’17
2017/06/09 - 2017/06/09 Symposium Session Chair - "7th Graduate Student Symposium on Molecular Imprinting"
Simpósio
 7th Graduate Student Symposium on Molecular Imprinting, Porto, Portugal, 8-9 Jun'17

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023 Nanotheranostics with microRNA: Applications in Radiotherapy
Arguente
 Sílvia Soares (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023 Autonomous biosensor for screening cancer biomarkers using passive Fuel Cells
Arguente
 Nádia Ferreira (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
2023 Nanozymes+/Driving Nanozymes towards stereochemical recognition: application to biomolecules of interest in health
Arguente
 Ana Rita Cardoso (Doutoramento)
Universidade Nova de Lisboa, Portugal
2023 Photonic protein-based hydrogel for sensing microRNAs in extracellular vesicles
Orientador
 Joana Martins (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022 Development of a biosensor based on plastic antibodies for the isolation and detection of extracellular vesicles
Orientador
 Mariana Amorim (Mestrado)
Universidade do Minho, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023 - 2024 Introduction to Chemical and Biochemical Engineering BSc in Chemical Engineering (Licenciatura) Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2023 - 2024 Chemical Engineering Laboratories II BSc in Chemical Engineering (Licenciatura) Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2021 - 2024 Biosensors MSc in Chemical Engineering / MSc in Biomedical Engineering (Mestrado) Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2005 - 2006 Environmental Toxicology Graduation in Aquatic Sciences Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2001 - 2003 Toxicology Graduation in Veterinary Medicine Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2018 STRIP2SENSE project ISEP News (http://www.isep.ipp.pt/New/ViewNew/5886)

Tutoria

Tópico Nome do aluno
2023/06/15 - 2023/12/31 Sustainable biomimetic materials to detect extracellular vesicles biomarkers Master fellow of MindGAP project
2022/05/23 - 2023/12/31 Molecularly imprinted polymers for protein biomarkers Master fellow of MindGAP project
2022/01/10 - 2022/06/10 Inverse opal photonic hydrogels for detection of bioactive compounds Master fellow of CY-SENSORS project
2021/04/19 - 2022/04/19 Development of fluorescent proteoliposomes for sensing applications Bachelor fellow of MindGAP project
2020/12/15 - 2021/12/15 Nanomaterials for sensing extracellular vesicles Master fellow of MindGAP project
2021/01/08 - 2021/08/08 Optical aptasensors to detect toxins Master fellow of CY-SENSORS project
2020/01/06 - 2020/05/05 Optical Materials in Sensing and Discovery of Bioactive Compounds Master fellow of CY-SENSORS project
2019/08/09 - 2020/01/16 Processing of biopolymers as responsive photonic materials Master fellow of STRIP2SENSE project
2019/01/21 - 2019/04/20 Photonic biopolymers for sensing cancer protein biomarkers Bachelor fellow of IBEROS project
2018/02/01 - 2019/03/31 Plastic antibodies on paper-based optical sensors for detection of cancer biomarkers Master fellow of CANCER project
2018/01/15 - 2019/03/14 Development of test strips to detect venous thromboembolism biomarkers - application to D-dimer Postdoctoral fellow of STRIP2SENSE project
2018/01/16 - 2019/01/05 Development of test strips to detect venous thromboembolism biomarkers - application to fibrinopeptide B Master fellow of STRIP2SENSE project
2018/04/02 - 2018/07/01 Dual electrochemical and optical responses for sensing cancer biomarkers Bachelor fellow of IBEROS project
2016/09/01 - 2017/09/01 Development of plastic antibodies to detect cancer biomarkers Master fellow of CANCER project
Distinções

Prémio

2022 SENSORS 2021 Best Cover Award
MDPI AG, Suiça