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Identification

Personal identification

Full name
NUNO FILIPE RAFAEL CANDEIAS

Citation names

  • Candeias, Nuno R.

Author identifiers

Ciência ID
F210-A39F-48A8
ORCID iD
0000-0003-2414-9064
Researcher Id
P-5008-2018
Scopus Author Id
6701759967

Email addresses

  • ncandeias@ua.pt (Professional)

Addresses

  • Campus de Santiago, Departamento de Química, 3810-193, Aveiro, Aveiro, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2020/01/01 - Current Assistant Professor (University Teacher) Universidade de Aveiro Departamento de Química, Portugal
Outputs

Publications

Book
  1. Candeias, Nuno R.. Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. United Kingdom: The Royal Society of Chemistry. 2016.
    Editor
Book chapter
  1. Nuno R. Candeias; Hélio M.T. Albuquerque. "Diazo-Mediated Homologation Reactions". edited by Vittorio Pace, 1-77. Wiley-VCH Verlag, 2023.
    10.1002/9783527830237.ch1
  2. Candeias, Nuno R.; Efimov, Alexander. "Thiopyrans and Their Benzo Derivatives". In Comprehensive Heterocyclic Chemistry IV, 512-670. Elsevier, 2022.
    10.1016/b978-0-12-818655-8.00020-2
  3. Candeias, Nuno. "1,4-addition to a,ß-unsaturated Carbonyl Compounds". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 420-423. United Kingdom: RSC, 2016.
  4. Candeias, Nuno; Paterna, R.; Cal, P.M.S.D.; Gois, P.M.P.. "Preparation of Phenylglycine and Hydroxymorpholine Derivatives Through a Petasis Borono–Mannich Reaction". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 439-442. United Kingdom: RSC, 2016.
  5. Siopa, F.; Candeias, Nuno R.; Afonso, Carlos A. M.. "Synthesis of the Antitumoral Drug 2,4,6-Tris(dimethylamino)-1,3,5-triazine via Sequential Nucleophilic Substitution". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 535-538. United Kingdom: RSC, 2016.
  6. Candeias, Nuno R.; Gois, P.M.P.; Afonso, Carlos A. M.. "Rhodium Carbene C–H Insertion in Water and Catalyst Reuse". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, 898-902. United Kingdom: RSC, 2016.
  7. Candeias, N.R.; Trindade, A.F.; Gois, P.M.P.; Afonso, C.A.M.. "3.19 The Wolff Rearrangement". In Comprehensive Organic Synthesis II, 944-991. Elsevier, 2014.
    10.1016/b978-0-08-097742-3.00325-6
  8. Nuno R. Candeias. "Inserção C-H de carbenóides de ródio em água e reutilização do catalisador". In 100 Experiências de Química Orgânica, edited by Afonso, Carlos A. M., 424-429. Portugal: IST PRESS, 2011.
  9. Nuno R. Candeias. "Preparação de um derivado de fenilglicina e hidroxi-morfolina por reacção de multicomponente Petasis-Borono Mannich". In 100 Experiências de Química Orgânica, edited by Afonso, Carlos A. M., 419-423. Portugal: IST PRESS, 2011.
  10. Afonso, Carlos A. M.; Branco, L.C.; Candeias, Nuno R.; Gois, P.M.P.; Lourenço, N.M.T.; Mateus, N.M.M.; Rosa, J.N.. "More Sustainable Synthetic Organic Chemistry Approaches Based On Catalytic Reuse". In A Portrait of State-of-the-Art Research at the Technical University of Lisbon. Springer Netherlands, 2007.
    10.1159/000368035
  11. Candeias, Nuno; Gois, P.M.P.; Branco, L.C.; Afonso, Carlos A. M.. "More sustainable methods for the synthesis of heterocycles". In Recent Research Developments in Heterocyclic Chemistry, edited by Melo, T. M. V. D. P.. Research Signpost Publishers, 2007.
Conference abstract
  1. Carrilho, João P.; Candeias, Nuno R.; Nunes, Alexandra. Corresponding author: Nunes, Alexandra. "NiPharmins: novel low resistance-inducing antimicrobials with antibiofilm activity against Staphylococcus aureus - work published on Conference Abstracts Book of Congress of Microbiology and Biotechnology 2023 (MICRO-BIOTEC'23), Covilhã, Portugal, 7th-9th December". 2023.
    Published
Conference poster
  1. Candeias, Nuno R.; Holmstedt, Suvi. Corresponding author: Candeias, Nuno R.. "Synthesis of Crematogaster nigriceps Metabolite Using O,O-Silyl Group Migrations of Quinic Acid Derivative". Paper presented in 22nd Tetrahedron Symposium, 2023.
  2. Vera M. S. Isca; Jaime A. S. Coelho; Carlos M. Monteiro; Epole Ntungwe N; Jelena Dinic; Diaz-Lanza Ana María; Candeias, Nuno R.; et al. "Novel class of P-glycoprotein inhibitors from Plectranthus spp.". Paper presented in WG3 meeting and International Online Symposium on “New Therapeutic Tools Against Preclinical Models of Multidrug Resistant Tumors”, 2020.
  3. Vera M. S. Isca; Jaime A. S. Coelho; Domínguez-Martín EM; Epole Ntungwe N; Carlos M. Monteiro; Dinic, Jelena; Diaz-Lanza Ana María; et al. "Royleanones from Plectranthus spp as P-glycoprotein inhibitors". Paper presented in Encontro Ciência 2020, 2020.
  4. Vera M. S. Isca; Ricardo J. Ferreira; Catarina Garcia; Monteiro, Carlos M.; Dinic, Jelena; Suvi Holmstedt; Pesic, Milica; et al. "Molecular Docking Studies of Promising P-Glycoprotein Inhibitors obtained from Plectranthus spp.". Paper presented in Italian Young Medicinal Chemistry Virtual Meeting (I-YMC-VMEET), 2020.
  5. Suvi Helena Holmstedt; Nuno R. Candeias. "A short total synthesis of natural carbasugars". Paper presented in 21st European Symposium on Organic Chemistry, 2019.
  6. Phuong Doan; Phung Nguyen; Vili Sipilä; Nuno R. Candeias; Olli Yli-Harja; Meenakshisundaram Kandhavelu. "Comparative evaluation of growth inhibitory effect of phenolic derivatives on human cancer cell lines". Paper presented in 44th FEBS Congress, 2019.
  7. Paola Vivo; Jagadish Salunke; Xing Guo; Joao R. Vale; Nuno R. Candeias; Mathias Nyman; Staffan Dahlström; et al. "Eco-friendly and low-cost phenothiazine-based hole-transporting material for high performance perovskite solar cells". Paper presented in LOPEC, 2019.
  8. Nuno R. Candeias; Benedicta Assoah; João Campos Do Vale; Luis F. Veiros. "Lewis Base Promoted Hydrosilylation of C=X Bonds with Pinacol-derived Chlorohydrosilane". Paper presented in XXVI National Meeting of the Portuguese Chemical Society, 2019.
  9. Suvi Helena Holmstedt; Nuno R. Candeias; Alisa Koivuporras. "En Route to New Bioactive Compounds from Natural Feedstock: Protection and Reduction of Quinic Acid". 2018.
  10. Candeias, Nuno. "New bioactive compounds from natural feedstock - Protection and reduction on quinic acid". Paper presented in 15th Eurasia Conference on Chemical Sciences,, 2018.
  11. Benedicta Assoah; Nuno R. Candeias; João Campos Do Vale. "DMPU catalyzed hydrosilylation of salicylaldehyde with pinacol-derived chlorosilane". Paper presented in 101st Canadian Chemistry Conference and Exhibition, 2018.
  12. Hien Le; Tatu Rimpiläinen; Saravanan KM; Olli Yli-Harja; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "Targeting P2Y1 receptor with novel agonists: design, synthesis, and inhibitory activity in prostate cancers". Paper presented in Biomeditech & med research day, 2018.
  13. Phuong Doan; Aliyu Musa; Vili Sipilä; Olli Yli-Harja; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "Alkylaminophenol induces growth inhibition, cell cycle arrest and apoptosis of cancer stem cells and non-cancer stem cells in glioblastoma". 2018.
  14. Nuno R. Candeias; João Campos Do Vale; Tatu Rimpiläinen; Carlos A.M. Afonso; Candeias, Nuno. "Auto-oxidative Condensation of 2-Aryl-2-lithio-1,3-dithianes". Paper presented in XXII International Conference on Organic Synthesis 22-ICOS, 2018.
  15. Candeias, Nuno; João Campos Do Vale; Nuno R. Candeias; Tatu Johannes Rimpiläinen; Carlos A.M. Afonso; Elina Sievänen. "Atmospheric oxidation of 1,3-dithianes and acyclic dithioacetals anions". Paper presented in International Symposium on Synthesis and Catalysis, 2017.
  16. Candeias, Nuno. "Reduction of Salicylaldehyde Using a Pinacol-Derived Chlorosilane/Lewis Base System". Paper presented in Trends in Organic Synthesis, Villars Summer School, 2017.
  17. Nuno R. Candeias; Candeias, Nuno. "Synthesis of antibacterial and antitumor alkylaminophenols by Petasis borono Mannich multicomponent reaction". Paper presented in XXV National Meeting of the Portuguese Society of Chemistry, 2017.
  18. Anastasia Zhurina; Anisha Viswanathan; Benedicta Assoah; A Paakkunainen; Olli Yli-Harja; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "Investigation of novel long-chain diol derivatives as potential growth inhibitors of glioblastoma". Paper presented in BioMediTech Research Day, 2017.
  19. Nuno R. Candeias; Benedicta Assoah. "Fossil Feedstock-free Preparation of Hydroquinone". Paper presented in 3rd Iberoamerican Organic Chemistry Symposium, 2016.
  20. Anzhelika Karjalainen; Phuong Doan; Ossi Sandberg; Olli Yli-Harja; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "Novel small molecules are found to exhibit cytotoxic effect on osteosarcoma cells". Paper presented in BioMediTech Research Day, 2015.
  21. Candeias, Nuno. "Efficient EDA Addition and Ring-Expansion Reaction of Isatins Catalyzed by a DBU/Rh(II) Metal-Organo System: On Route to the Synthesis of Viridicatin Alkaloids". Paper presented in 10th National Meeting of Organic Chemistry of the Portuguese Society of Chemistry, 2013.
  22. Candeias, Nuno. "Homochiral Dirhodium(II) Catalysts Derived from Natural Amino Acids for the Aqueous Asymmetric Intramolecular C-H Insertion of a-Diazo Acetamides". Paper presented in 18th European Symposium in Organic Chemistry, 2013.
  23. Candeias, Nuno. "Four Component Assembly of Chiral N-B Heterocycles with a Natural Product-Like Framework". Paper presented in 6th Spanish-Portuguese-Japanese Organic Chemistry Symposium, 2012.
  24. Candeias, Nuno; Candeias, N.R.; Carias, C.; Gomes, L.F.R.; André, V.; Duarte, M.T.; Gois, P.M.P.; Afonso, C.A.M.. "Asymmetric intramolecular C-H insertion of a-diazo acetamides in water by Dirhodium(II) catalysts derived from natural amino acids". Paper presented in Challenges in Organic Chemistry and Chemical Biology 7, 2012.
    10.1002/adsc.201200101
  25. Candeias, Nuno. "Syntheses of 3-Hydroxy-Quinolin-2-ones by Metal-Organo Catalyzed Eistert Ring Expansion of 3-Hydroxy-Oxindoles". Paper presented in XXII National Meeting of the Portuguese Society of Chemistry, 2011.
  26. Candeias, Nuno. "Competitive Wolff Rearrangement Catalyzed By Rhodium(II) Complexes". Paper presented in 8th National Meeting of Organic Chemistry of the Portuguese Society of Chemistry, 2010.
  27. Mohammadi Pirouz, H.; Tavakoli Bina, M.. "Water as a suitable medium for the Petasis-Borono Mannich reaction". Paper presented in 2nd Portuguese Young Chemists Meeting of the Portuguese Society of Chemistry, 2010.
    10.1109/ipecon.2010.5697045
  28. Potapov, Andrei; Kluchenko, Maxim; Kadirov, Pulat; Kuznetsova, Anastasiya. "Is water a suitable medium for the Petasis borono-Mannich reaction? A DFT study comparison between possible media". Paper presented in 10th Tetrahedron Symposium, 2009.
  29. Candeias, Nuno. "Intramolecular Asymmetric C-H Insertion of ¿-Diazoacetamides in Water". Paper presented in 1st Portuguese Young Chemists Meeting of the Portuguese Society of Chemistry, 2008.
  30. Candeias, Nuno. "Photolytic C-H insertion of alfa-Diazo-alfa-Diethoxyphosphoryl Acetamides with retention of configuration". Paper presented in 2nd EuCheMS European Chemistry Congress, 2008.
  31. Candeias, Nuno. "Preparation of New Chiral Dirhodium (II) Catalysts and Decomposition of alfa-Diazo Acetamides in Water". Paper presented in 8th National Meeting of Catalysis and Porous Material of the Portuguese Society of Chemistry, 2007.
  32. Candeias, Nuno. "C-H CARBENE INSERTION OF alfa-DIAZO ACETAMIDES BY PHOTOLYSIS IN NON-CONVENTIONAL MEDIA". Paper presented in 7th National Meeting of Organic Chemistry of the Portuguese Society of Chemistry, 2007.
  33. Candeias, Nuno. "C-H carbene insertion of alfa-Diazo-alfa-diethoxyphosphoryl acetamides by photolysis in non-conventional media". Paper presented in 1st International IUPAC Conference on Green-Sustainable Chemistry, 2006.
  34. Candeias, Nuno. "Rh(II) Catalyzed Intramolecular Intramolecular C-H Insertion alfa-Diazo-Acetamides in Water". Paper presented in 1st EuCheMS European Chemistry Congress, 2006.
  35. Candeias, Nuno. "STUDIES ON DIRHODIUM(II)-CATALYSED INTRAMOLECULAR C-H INSERTION OF DIAZO SUBSTRATES IN WATER". Paper presented in 14th European Symposium On Organic Chemistry, 2005.
Journal article
  1. Bangay, Gabrielle; Brauning, Florencia Z.; Kowalczyk, Tomasz; Merecz-Sadowska, Anna; Synowiec, Ewelina; Sliwinski, Tomasz; Candeias, Nuno; et al. "Halimane Derivatives from Plectranthus ornatus Codd. as Novel Anti-cancer Agents". Biomedicine & Pharmacotherapy 174 (2024): 116516. http://dx.doi.org/10.1016/j.biopha.2024.116516.
    Published • 10.1016/j.biopha.2024.116516
  2. Petkov, Hristo; Ravutsov, Martin A.; Verganista, Manuel J.; Mitrev, Yavor N.; Candeias, Nuno R.; Simeonov, Svilen P.. "Cu-Catalyzed Tandem Oxidation-Intramolecular Cannizzaro Reaction of Biorenewables and Bioactive Molecules". ChemSusChem (2024): http://dx.doi.org/10.1002/cssc.202400013.
    In press • 10.1002/cssc.202400013
  3. Akshaya Murugesan; Sana Kari; Anita Shrestha; Benedicta Assoah; Konda Mani Saravanan; Monica Murugesan; Ramesh Thiyagarajan; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "Methanodibenzo[b,f][1,5]dioxocins as Novel Glutaminase Inhibitor with Anti-Glioblastoma Potential". Cancers (2023): https://doi.org/10.3390/cancers15041010.
    10.3390/cancers15041010
  4. Miroslav Dangalov; Adolfo Fernández-Figueiras; Martin A. Ravutsov; Ekaterina Vakarelska; Maya K. Marinova; Nuno R. Candeias; Svilen P. Simeonov. "Ru-Catalyzed Isomerization of Achmatowicz Derivatives: A Sustainable Route to Biorenewables and Bioactive Lactones". ACS Catalysis (2023): https://doi.org/10.1021/acscatal.2c04867.
    10.1021/acscatal.2c04867
  5. Jeyalakshmi Kandhavelu; Kumar Subramanian; Vivash Naidoo; Giulia Sebastianelli; Phuong Doan; Saravanan Konda Mani; Hande Yapislar; et al. "A novel EGFR inhibitor, HNPMI, regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer". British Journal of Pharmacology (2023): https://researchportal.tuni.fi/en/publications/c722f80f-3966-4511-ab05-d0372ee6b057.
    10.1111/bph.16141
  6. João R. Vale; Rafael F. Gomes; Carlos A. M. Afonso; Nuno R. Candeias. "Functionalized Cyclopentenes via the Formal [4+1] Cycloaddition of Photogenerated Siloxycarbenes from Acyl Silanes". The Journal of Organic Chemistry (2022): https://doi.org/10.1021/acs.joc.2c00591.
    10.1021/acs.joc.2c00591
  7. Epole N. Ntungwe; Sofija Jovanovic Stojanov; Noélia M. Duarte; Nuno R. Candeias; Ana M. Díaz-Lanza; Máté Vágvölgyi; Attila Hunyadi; Milica Pešic; Patrícia Rijo. "C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators". ACS Medicinal Chemistry Letters (2022): https://doi.org/10.1021/acsmedchemlett.1c00711.
    10.1021/acsmedchemlett.1c00711
  8. Hien Thi Thu Le; Murugesan, Akshaya; Candeias, Nuno R.; Ramesh, Thiyagarajan; Yli-Harja, Olli; Kandhavelu, Meenakshisundaram. Corresponding author: Kandhavelu, Meenakshisundaram. "P2Y1 agonist HIC in combination with androgen receptor inhibitor abiraterone acetate impairs cell growth of prostate cancer". Apoptosis (2022): http://dx.doi.org/10.1007/s10495-022-01716-1.
    10.1007/s10495-022-01716-1
  9. Nguyen, Phung; Doan, Phuong; Murugesan, Akshaya; Ramesh, Thiyagarajan; Rimpilainen, Tatu; Candeias, Nuno R.; Yli-Harja, Olli; Kandhavelu, Meenakshisundaram. "GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma". Life Sciences 291 (2022): 120307. http://dx.doi.org/10.1016/j.lfs.2022.120307.
    10.1016/j.lfs.2022.120307
  10. Catarina IV Ramos; Vitor A. S. Almodovar; Candeias, Nuno R.; Tiago Santos; Carla Cruz; Maria Graça Neves; Tomé, Augusto C.. Corresponding author: Tomé, Augusto C.. "Diketopyrrolo[3,4–c]pyrrole derivative as a promising ligand for the stabilization of G-quadruplex DNA structures". Bioorganic Chemistry (2022): 105703-105703. http://dx.doi.org/10.1016/j.bioorg.2022.105703.
    10.1016/j.bioorg.2022.105703
  11. Essi Taipale; Nikita A. Durandin; Jagadish K. Salunke; Nuno R. Candeias; Tero-Petri Ruoko; Jas S. Ward; Arri Priimagi; Kari Rissanen. "Protonation-induced fluorescence modulation of carbazole-based emitters". Materials Advances (2022): https://doi.org/10.1039/D1MA00438G.
    10.1039/D1MA00438G
  12. Hien Thi Thu Le; Akshaya Murugesan; Nuno R. Candeias; Olli Yli-Harja; Meenakshisundaram Kandhavelu. "Functional characterization of HIC, a P2Y1 agonist, as a p53 stabilizer for prostate cancer cell death induction". Future Medicinal Chemistry (2021): https://researchportal.tuni.fi/en/publications/6f378b3b-e2d1-4454-9b82-75308510162e.
    10.4155/fmc-2021-0159
  13. Tatu Rimpiläinen; Alexandra Nunes; Rita Calado; Ana S. Fernandes; Joana Andrade; Epole Ntungwe; Gabriella Spengler; et al. "Increased antibacterial properties of indoline-derived phenolic Mannich bases". European Journal of Medicinal Chemistry 220 (2021): 113459-113459. https://researchportal.tuni.fi/en/publications/39b3a157-992e-4398-8cef-d1c956c757c0.
    10.1016/j.ejmech.2021.113459
  14. Doan, Phuong; Nguyen, Phung; Murugesan, Akshaya; Candeias, Nuno R.; Yli-Harja, Olli; Kandhavelu, Meenakshisundaram. "Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity". Cells 10 8 (2021): 1975. http://dx.doi.org/10.3390/cells10081975.
    10.3390/cells10081975
  15. Nguyen, Phung; Doan, Phuong; Rimpilainen, Tatu; Konda Mani, Saravanan; Murugesan, Akshaya; Yli-Harja, Olli; Candeias, Nuno R.; Kandhavelu, Meenakshisundaram. "Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment". Journal of Medicinal Chemistry 64 15 (2021): 10908-10918. http://dx.doi.org/10.1021/acs.jmedchem.1c00277.
    10.1021/acs.jmedchem.1c00277
  16. Suvi Holmstedt; Alexander Efimov; Nuno R. Candeias. "O,O-Silyl Group Migrations in Quinic Acid Derivatives: An Opportunity for Divergent Synthesis". Organic Letters 23 8 (2021): 3083-3087. https://doi.org/10.1021/acs.orglett.1c00755.
    10.1021/acs.orglett.1c00755
  17. Raquel R. Lopes; Catarina S. Tomé; Roberto Russo; Roberta Paterna; João Leandro; Nuno R. Candeias; Lídia M. D. Gonçalves; et al. "Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives". Biomolecules 11 3 (2021): 462-462. https://doi.org/10.3390/biom11030462.
    10.3390/biom11030462
  18. Anisha Viswanathan; Aliyu Musa; Akshaya Murugesan; João R. Vale; Carlos A. M. Afonso; Saravanan Konda Mani; Olli Yli-Harja; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "Erratum: Viswanathan, A., et al. Battling Glioblastoma: A Novel Tyrosine Kinase Inhibitor with Multi-Dimensional Anti-Tumor Effect (Running Title: Cancer Cells Death Signalling Activation). Cells 2019, 8, 1624". Cells 9 12 (2020): 2631-2631. https://doi.org/10.3390/cells9122631.
    10.3390/cells9122631
  19. Catarina Garcia; Vera M.S. Isca; Filipe Pereira; Carlos M. Monteiro; Epole Ntungwe; Francisco Sousa; Jelena Dinic; et al. "Royleanone Derivatives From Plectranthus spp. as a Novel Class of P-Glycoprotein Inhibitors". Frontiers in Pharmacology 11 (2020): https://researchportal.tuni.fi/en/publications/64a78adb-0dde-411e-b6d9-61956361d430.
    10.3389/fphar.2020.557789
  20. Suvi Holmstedt; Lijo George; Alisa Koivuporras; Arto Valkonen; Nuno R. Candeias. "Deoxygenative Divergent Synthesis: En Route to Quinic Acid Chirons". Organic Letters (2020): https://doi.org/10.1021/acs.orglett.0c02995.
    10.1021/acs.orglett.0c02995
  21. Jagadish Salunke; Xing Guo; Maning Liu; Zhenhua Lin; Nuno R. Candeias; Arri Priimagi; Jingjing Chang; Paola Vivo. "N-Substituted Phenothiazines as Environmentally Friendly Hole-Transporting Materials for Low-Cost and Highly Stable Halide Perovskite Solar Cells". ACS Omega (2020): https://doi.org/10.1021/acsomega.0c03184.
    10.1021/acsomega.0c03184
  22. Vera M. S. Isca; Ricardo J. Ferreira; Catarina Garcia; Carlos M. Monteiro; Jelena Dinic; Suvi Holmstedt; Vânia André; et al. "Molecular Docking Studies of Royleanone Diterpenoids from Plectranthus spp. as P-Glycoprotein Inhibitors". ACS Medicinal Chemistry Letters (2020): https://doi.org/10.1021/acsmedchemlett.9b00642.
    10.1021/acsmedchemlett.9b00642
  23. Phuong Doan; Aliyu Musa; Akshaya Murugesan; Vili Sipilä; Nuno R. Candeias; Frank Emmert-Streib; Pekka Ruusuvuori; et al. "Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol through the Modulation of EGFR and CSC Signaling Pathways". Cells 9 3 (2020): 681-681. https://doi.org/10.3390/cells9030681.
    10.3390/cells9030681
  24. Suvi Helena Holmstedt; Nuno R. Candeias. "A concise synthesis of carbasugars isolated from Streptomyces lincolnensis". Tetrahedron (2020): https://tutcris.tut.fi/portal/en/publications/a-concise-synthesis-of-carbasugars-isolated-from-streptomyces-lincolnensis(51d54a29-d411-4373-8406-0bee745ae9ce).html.
    10.1016/j.tet.2020.131346
  25. Akshaya Murugesan; Suvi Helena Holmstedt; Kenna C. Brown; Alisa Koivuporras; Ana S. Macedo; Nga Nguyen; Pedro Fonte; et al. "Design and synthesis of novel quinic acid derivatives". Future Medicinal Chemistry 12 21 (2020): 1891-1910. https://researchportal.tuni.fi/en/publications/d74140b0-0242-4ea9-9ca9-4ae445658e4e.
    10.4155/fmc-2020-0194
  26. Hien Thi Thu Le; Tatu Rimpilainen; Saravanan Konda Mani; Akshaya Murugesan; Olli Yli-Harja; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "Synthesis and preclinical validation of novel P2Y1 receptor ligands as a potent anti-prostate cancer agent". Scientific Reports 9 (2019): https://tutcris.tut.fi/portal/en/publications/synthesis-and-preclinical-validation-of-novel-p2y1-receptor-ligands-as-a-potent-antiprostate-cancer-agent(52ec9011-f654-472f-8e2b-5ecda6bcd925).html.
    10.1038/s41598-019-55194-8
  27. Anisha Viswanathan; Aliyu Musa; Akshaya Murugesan; João R. Vale; Carlos A. M. Afonso; Saravanan Konda Mani; Olli Yli-Harja; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "Battling Glioblastoma: A Novel Tyrosine Kinase Inhibitor with Multi-Dimensional Anti-Tumor Effect (Running Title: Cancer Cells Death Signalling Activation)". Cells (2019): https://doi.org/10.3390/cells8121624.
    10.3390/cells8121624
  28. Anisha Viswanathan; Giulia Sebastianelli; Kenna Brown; Jenna Raunio; Vili Sipilä; Olli Yli-Harja; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "In vitro anti-glioblastoma activity of L-valine derived boroxazolidones". European Journal of Pharmacology 854 (2019): 194-200. https://tutcris.tut.fi/portal/en/publications/in-vitro-antiglioblastoma-activity-of-lvaline-derived-boroxazolidones(52bd770b-0024-4956-a5a6-e783f81d7387).html.
    10.1016/j.ejphar.2019.04.020
  29. Benedicta Assoah; Vesa Riihonen; João R. Vale; Arto Valkonen; Nuno R. Candeias. "Synthesis of 6,12-Disubstituted Methanodibenzo[b,f][1,5]dioxocins: Pyrrolidine Catalyzed Self-Condensation of 2'-Hydroxyacetophenones". Molecules (2019): https://doi.org/10.3390/molecules24132405.
    10.3390/molecules24132405
  30. Jagadish Salunke; Xing Guo; Zhenhua Lin; João R. Vale; Nuno R. Candeias; Mathias Nyman; Staffan Dahlström; et al. "Phenothiazine-Based Hole-Transporting Materials toward Eco-friendly Perovskite Solar Cells". ACS Applied Energy Materials 2 5 (2019): 3021-3027. https://doi.org/10.1021/acsaem.9b00408.
    10.1021/acsaem.9b00408
  31. Assoah, Benedicta; Veiros, Luis F.; Candeias, Nuno R.. "Pinacol-Derived Chlorohydrosilane in Metal-Free Reductive Amination for the Preparation of Tertiary Alkylphenolmethyl Amines". Organic Letters (2019): http://dx.doi.org/10.1021/acs.orglett.9b00121.
    Open access • In press • 10.1021/acs.orglett.9b00121
  32. Phuong Doan; Aliyu Musa; Nuno R. Candeias; Frank Emmert-Streib; Olli Yli-Harja; Meenakshisundaram Kandhavelu. "Alkylaminophenol induces G1/S phase cell cycle arrest in glioblastoma cells through p53 and cyclin-dependent kinase signaling pathway". Frontiers in Pharmacology 10 APR (2019): https://tutcris.tut.fi/portal/en/publications/alkylaminophenol-induces-g1s-phase-cell-cycle-arrest-in-glioblastoma-cells-through-p53-and-cyclindependent-kinase-signaling-pathway(5eeeaded-93a8-439f-aed8-8964adb1ed96).html.
    10.3389/fphar.2019.00330
  33. Natalia E. Grammatikova; Lijo George; Zafar Ahmed; Nuno R. Candeias; Nikita A. Durandin; Alexander Efimov; Grammatikova, N.E.; et al. "Zinc phthalocyanine activated by conventional indoor light makes a highly efficient antimicrobial material from regular cellulose". Journal of Materials Chemistry B 7 28 (2019): 4379-4384. https://doi.org/10.1039/C9TB01095E.
    10.1039/C9TB01095E
  34. João R. Vale; Arto Valkonen; Carlos A. M. Afonso; Nuno R. Candeias. "Synthesis of silacyclopent-2-en-4-ols via intramolecular [2 + 2] photocycloaddition of benzoyl(allyl)silanes". Organic Chemistry Frontiers (2019): https://doi.org/10.1039/C9QO01028A.
    10.1039/C9QO01028A
  35. Rimpiläinen, Tatu; Andrade, Joana; Nunes, Alexandra; Ntungwe, Epole; Fernandes, Ana S.; Vale, João R.; Rodrigues, João; et al. "Aminobenzylated 4-Nitrophenols as Antibacterial Agents Obtained from 5-Nitrosalicylaldehyde through a Petasis Borono–Mannich Reaction". ACS Omega 3 11 (2018): 16191-16202. http://dx.doi.org/10.1021/acsomega.8b02381.
    Open access • 10.1021/acsomega.8b02381
  36. Anisha Viswanathan; Anastasia Zhurina; Benedicta Assoah; Aleksi Paakkunainen; Aliyu Musa; Dinesh Kute; Konda Mani Saravanan; et al. "Decane-1,2-diol derivatives as potential antitumor agents for the treatment of glioblastoma". European Journal of Pharmacology 837 (2018): 105-116. https://tutcris.tut.fi/portal/en/publications/decane12diol-derivatives-as-potential-antitumor-agents-for-the-treatment-of-glioblastoma(4d8bb7f0-ef65-46b7-83c0-f3fb8a0b3524).html.
    10.1016/j.ejphar.2018.08.041
  37. Candeias, Nuno R.; Assoah, Benedicta; Simeonov, Svilen P.. "Production and Synthetic Modifications of Shikimic Acid". Chemical Reviews 118 20 (2018): 10458-10550. http://dx.doi.org/10.1021/acs.chemrev.8b00350.
    10.1021/acs.chemrev.8b00350
  38. Salunke, Jagadish K.; Durandin, Nikita A.; Ruoko, Tero-Petri; Candeias, Nuno R.; Vivo, Paola; Vuorimaa-Laukkanen, Elina; Laaksonen, Timo; Priimagi, Arri. "Halogen-Bond-Assisted Photoluminescence Modulation in Carbazole-Based Emitter". Scientific Reports 8 1 (2018): 14431. http://dx.doi.org/10.1038/s41598-018-32830-3.
    Open access • 10.1038/s41598-018-32830-3
  39. Benedicta Assoah; João R. Vale; Elina Kalenius; Luis F. Veiros; Nuno R. Candeias. "Lewis Base Catalyzed Intramolecular Reduction of Salicylaldehydes by Pinacol-Derived Chlorohydrosilane". European Journal of Organic Chemistry 2018 23 (2018): 2910-2917. https://doi.org/10.1002/ejoc.201800544.
    10.1002/ejoc.201800544
  40. João R. Vale; Tatu Rimpiläinen; Elina Sievänen; Kari Rissanen; Carlos A. M. Afonso; Nuno R. Candeias. "Pot-Economy Autooxidative Condensation of 2-Aryl-2-lithio-1,3-dithianes". The Journal of Organic Chemistry 83 4 (2018): 1948-1958. https://doi.org/10.1021/acs.joc.7b02896.
    Open access • 10.1021/acs.joc.7b02896
  41. Candeias, Nuno. "Highly Efficient Energy Transfer Cassettes by Assembly of Boronic Acid Derived Salicylidenehydrazone Complexes". ChemPhotoChem (2018):
    10.1002/cptc.201800150
  42. Phuong Doan; Tien Nguyen; Olli Yli-Harja; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "Effect of alkylaminophenols on growth inhibition and apoptosis of bone cancer cells". European Journal of Pharmaceutical Sciences 107 (2017): 208–216-208–216. https://tutcris.tut.fi/portal/en/publications/effect-of-alkylaminophenols-on-growth-inhibition-and-apoptosis-of-bone-cancer-cells(e946fd21-6e08-4e7c-97b3-bd7205c616e1).html.
    10.1016/j.ejps.2017.07.016
  43. D. B. Shinde; Jagadish K. Salunke; Nuno R. Candeias; Tinti Francesca; Gazzano Massimo; P. P. Wadgaonkar; Arri Priimägi; Camaioni Nadia; Paola Vivo. "Crystallisation-enhanced bulk hole mobility in phenothiazine-based organic semiconductors". Scientific Reports 7 (2017): https://tutcris.tut.fi/portal/en/publications/crystallisationenhanced-bulk-hole-mobility-in-phenothiazinebased-organic-semiconductors(8987629d-3d49-4524-ad40-2d386bca643e).html.
    10.1038/srep46268
  44. Anzhelika Karjalainen; Phuong Doan; Ossi Sandberg; Jerome Chandraseelan; Olli Yli-Harja; Nuno Candeias; Meenakshisundaram Kandhavelu. "Synthesis of phenol-derivatives and biological screening for anticancer activity". Anti-Cancer Agents in Medicinal Chemistry 17 999 (2017): 1-1. https://doi.org/10.2174%2F1871520617666170327142027.
    10.2174/1871520617666170327142027
  45. Raunio J.; J. Mannoja; T. Nguyen; Ahmad N.; Kemppainen N. M.; R. G. Franzén; M. Kandhavelu; et al. "Base catalysed N-functionalisation of boroxazolidones". RSC Advances 7 33 (2017): 20620-20627. https://tutcris.tut.fi/portal/en/publications/base-catalysed-nfunctionalisation-of-boroxazolidones(5e593a7e-72e5-43c9-94a4-b6e734fa4f3a).html.
    10.1039/c7ra03266h
  46. Íris Neto; Joana Andrade; A. S. Fernandes; Catarina Pinto Reis; Jagadish K. Salunke; Arri Priimagi; Nuno R. Candeias; Patrícia Rijo. "Multicomponent Petasis-borono Mannich Preparation of Alkylaminophenols and Antimicrobial Activity Studies". ChemMedChem (2016): http://dx.doi.org/10.1002/cmdc.201600244.
    10.1002/cmdc.201600244
  47. Benedicta Assoah; Luis F. Veiros; Carlos A. M. Afonso; Nuno R. Candeias. "Biomass-Based and Oxidant-Free Preparation of Hydroquinone from Quinic Acid". European Journal of Organic Chemistry (2016): http://dx.doi.org/10.1002/ejoc.201600616.
    10.1002/ejoc.201600616
  48. Phuong Doan; Anzhelika Karjalainen; Jerome G. Chandraseelan; Ossi Sandberg; Olli Yli-Harja; Tomi Rosholm; Robert Franzén; Nuno R. Candeias; Meenakshisundaram Kandhavelu. "Synthesis and biological screening for cytotoxic activity of N-substituted indolines and morpholines". European Journal of Medicinal Chemistry 120 (2016): 296-303. https://tutcris.tut.fi/portal/en/publications/synthesis-and-biological-screening-for-cytotoxic-activity-of-nsubstituted-indolines-and-morpholines(8bf2413a-d711-4fc8-941d-b85a7f75f9b0).html.
    10.1016/j.ejmech.2016.05.024
  49. Candeias, N.R.; Paterna, R.; Gois, P.M.P.. "Homologation Reaction of Ketones with Diazo Compounds". Chemical Reviews 116 5 (2016): 2937-2981. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960533387&partnerID=MN8TOARS.
    10.1021/acs.chemrev.5b00381
  50. Santos, F.M.F.; Rosa, J.N.; Candeias, N.R.; Carvalho, C.P.; Matos, A.I.; Ventura, A.E.; Florindo, H.F.; et al. "A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Chemistry - A European Journal (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84950262633&partnerID=MN8TOARS.
    10.1002/chem.201503943
  51. Rosholm, T.; Gois, P.M.P.; Franzen, R.; Candeias, N.R.. "Glycerol as an efficient medium for the Petasis borono-mannich reaction". ChemistryOpen 4 1 (2015): 39-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923272529&partnerID=MN8TOARS.
    10.1002/open.201402066
  52. Frija, L.M.T.; Garcia, H.; Rodrigues, C.; Martins, I.; Candeias, N.R.; André, V.; Duarte, M.T.; Pereira, C.S.; Afonso, C.A.M.. "Short synthesis of the natural product 3ß-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid". Phytochemistry Letters 6 2 (2013): 165-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873029460&partnerID=MN8TOARS.
    10.1016/j.phytol.2012.12.005
  53. Paterna, R.; André, V.; Duarte, M.T.; Veiros, L.F.; Candeias, N.R.; Gois, P.M.P.. "Ring-expansion reaction of isatins with ethyl diazoacetate catalyzed by dirhodium(II)/DBU metal-organic system: En route to viridicatin alkaloids". European Journal of Organic Chemistry 28 (2013): 6280-6290. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884901070&partnerID=MN8TOARS.
    10.1002/ejoc.201300796
  54. Candeias, N.R.; Afonso, C.A.M.; Gois, P.M.P.. "Making expensive dirhodium(II) catalysts cheaper: Rh(ii) recycling methods". Organic and Biomolecular Chemistry 10 17 (2012): 3357-3378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859804831&partnerID=MN8TOARS.
    10.1039/c2ob06731e
  55. Montalbano, F.; Candeias, N.R.; Veiros, L.F.; André, V.; Duarte, M.T.; Bronze, M.R.; Moreira, R.; Gois, P.M.P.. "Four-component assembly of chiral N-B heterocycles with a natural product-like framework". Organic Letters 14 4 (2012): 988-991. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857215037&partnerID=MN8TOARS.
    10.1021/ol203224n
  56. Zakrzewska, M.E.; Cal, P.M.S.D.; Candeias, N.R.; Bogel-Lukasik, R.; Afonso, C.A.M.; Ponte, M.N.; Gois, P.M.P.. "Intramolecular C-H insertion catalyzed by dirhodium(II) complexes using CO 2 as the reaction media". Green Chemistry Letters and Reviews 5 2 (2012): 211-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859505886&partnerID=MN8TOARS.
    10.1080/17518253.2011.620009
  57. Candeias, N.R.; Paterna, R.; Cal, P.M.S.D.; Góis, P.M.P.. "A sustainable protocol for the aqueous multicomponent Petasis borono-Mannich reaction". Journal of Chemical Education 89 6 (2012): 799-802. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860772984&partnerID=MN8TOARS.
    10.1021/ed200509q
  58. Tan, B.; Candeias, N.R.; Barbas III, C.F.. "Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst". Nature Chemistry 3 6 (2011): 473-477. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957462689&partnerID=MN8TOARS.
    10.1038/nchem.1039
  59. Tan, B.; Candeias, N.R.; Barbas, C.F.. "Core-structure-motivated design of a phosphine-catalyzed [3 + 2] cycloaddition reaction: Enantioselective syntheses of spirocyclopenteneoxindoles". Journal of the American Chemical Society 133 13 (2011): 4672-4675. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953843860&partnerID=MN8TOARS.
    10.1021/ja110147w
  60. Candeias, N.R.; Cal, P.M.S.D.; André, V.; Duarte, M.T.; Veiros, L.F.; Gois, P.M.P.. "Water as the reaction medium for multicomponent reactions based on boronic acids". Tetrahedron 66 14 (2010): 2736-2745. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649179431&partnerID=MN8TOARS.
    10.1016/j.tet.2010.01.084
  61. Frade, R.F.M.; Candeias, N.R.; Duarte, C.M.M.; André, V.; Teresa Duarte, M.; Gois, P.M.P.; Afonso, C.A.M.. "New dirhodium complex with activity towards colorectal cancer". Bioorganic and Medicinal Chemistry Letters 20 11 (2010): 3413-3415. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953479257&partnerID=MN8TOARS.
    10.1016/j.bmcl.2010.04.002
  62. Bui, T.; Candeias, N.R.; Barbas, C.F.. "Dimeric quinidine-catalyzed enantioselective aminooxygenation of oxindoles: An organocatalytic approach to 3-hydroxyoxindole derivatives". Journal of the American Chemical Society 132 16 (2010): 5574-5575. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952578835&partnerID=MN8TOARS.
    10.1021/ja101032j
  63. Candeias, N.R.; Montalbano, F.; Cal, P.M.S.D.; Gois, P.M.P.. "Boronic acids and esters in the petasis-borono mannich multicomponent reaction". Chemical Reviews 110 10 (2010): 6169-6193. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958034343&partnerID=MN8TOARS.
    10.1021/cr100108k
  64. Rosa, J.N.; Reddy, R.S.; Candeias, N.R.; Cal, P.M.S.D.; Gois, P.M.P.. "NHC-iron-catalyzed aerobic oxidative aromatic esterification of aldehydes using boronic acids". Organic Letters 12 12 (2010): 2686-2689. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953592111&partnerID=MN8TOARS.
    10.1021/ol100302e
  65. Nuno R. Candeias; Luis F. Veiros; Carlos A. M. Afonso; Pedro M. P. Gois. "Water: A Suitable Medium for the Petasis Borono-Mannich Reaction". European Journal of Organic Chemistry 12 (2009): 1859-1863. https://tutcris.tut.fi/portal/en/publications/water-a-suitable-medium-for-the-petasis-boronomannich-reaction(948f1d5a-a8b7-4bbb-9b5e-0d3f7988c68d).html.
    10.1002/ejoc.200900056
  66. Candeias, N.R.; Afonso, C.A.M.. "Developments in the photochemistry of diazo compounds". Current Organic Chemistry 13 7 (2009): 763-787. http://www.scopus.com/inward/record.url?eid=2-s2.0-69249087759&partnerID=MN8TOARS.
    10.2174/138527209788167231
  67. Candeias, N.R.; Branco, L.C.; Gois, P.M.P.; Afonso, C.A.M.; Trindade, A.F.. "More sustainable approaches for the synthesis of n-based heterocycles". Chemical Reviews 109 6 (2009): 2703-2802. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649337286&partnerID=MN8TOARS.
    10.1021/cr800462w
  68. Gomes, L.F.R.; Trindade, A.F.; Candeias, N.R.; Veiros, L.F.; Gois, P.M.P.; Afonso, C.A.M.. "Cyclization of diazoacetamides catalyzed by N-heterocyclic carbene dirhodium(II) complexes". Synthesis 20 (2009): 3519-3526. http://www.scopus.com/inward/record.url?eid=2-s2.0-72049126649&partnerID=MN8TOARS.
    10.1055/s-0029-1217005
  69. Gomes, L.F.R.; Trindade, A.F.; Candeias, N.R.; Gois, P.M.P.; Afonso, C.A.M.. "Intramolecular C-H insertion using NHC-di-rhodium(II) complexes: the influence of axial coordination". Tetrahedron Letters 49 52 (2008): 7372-7375. http://www.scopus.com/inward/record.url?eid=2-s2.0-55549094769&partnerID=MN8TOARS.
    10.1016/j.tetlet.2008.10.054
  70. Candeias, N.R.; Gois, P.M.P.; Veiros, L.F.; Afonso, C.A.M.. "C-H carbene insertion of a-diazo acetamides by photolysis in non-conventional media". Journal of Organic Chemistry 73 15 (2008): 5926-5932. http://www.scopus.com/inward/record.url?eid=2-s2.0-48249150763&partnerID=MN8TOARS.
    10.1021/jo800980c
  71. Candeias, N.R.; Gois, P.M.P.; Afonso, C.A.M.. "Rhodium (II) carbene C-H insertion in water and catalyst reuse | Inserção C-H de carbenóides de ródio em água e reutilização do catalisador". Quimica Nova 30 7 (2007): 1768-1772. http://www.scopus.com/inward/record.url?eid=2-s2.0-40849100151&partnerID=MN8TOARS.
    10.1590/S0100-40422007000700047
  72. Afonso, C.A.M.; Branco, L.C.; Candeias, N.R.; Gois, P.M.P.; Lourenço, N.M.T.; Mateus, N.M.M.; Rosa, J.N.. "Efficient catalyst reuse by simple dissolution in non-conventional media". Chemical Communications 26 (2007): 2669-2679. http://www.scopus.com/inward/record.url?eid=2-s2.0-34347272296&partnerID=MN8TOARS.
    10.1039/b607483a
  73. Candeias, N.R.; Gois, P.M.P.; Afonso, C.A.M.. "Rh(II)-catalyzed intramolecular C-H insertion of diazo substrates in water: Scope and limitations". Journal of Organic Chemistry 71 15 (2006): 5489-5497. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746356562&partnerID=MN8TOARS.
    10.1021/jo060397a
  74. Candeias, N.R.; Gois, P.M.P.; Afonso, C.A.M.. "Rh(II) catalysed intramolecular C-H insertion of diazo substrates in water: A simple and efficient approach to catalyst reuse". Chemical Communications 3 (2005): 391-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-13244269838&partnerID=MN8TOARS.
    10.1039/b414233k
  75. P. Gois, P.M.; Candeias, N.R.; Afonso, C.A.M.. "Preparation of enantioselective enriched a-(dialkoxyphosphoryl) lactams via intramolecular C-H insertion with chiral dirhodium(II) catalysts". Journal of Molecular Catalysis A: Chemical 227 1-2 (2005): 17-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-11844283284&partnerID=MN8TOARS.
    10.1016/j.molcata.2004.09.041
  76. Candeias, N.R.; Afonso, C.A.M.. "Preparation of non-fused heterocycles in zeolites and mesoporous materials". Journal of Molecular Catalysis A: Chemical 242 1-2 (2005): 195-217. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744477522&partnerID=MN8TOARS.
    10.1016/j.molcata.2005.07.042
Magazine article
  1. Candeias, Nuno. ""Carbenos em Água: Reactivos, mas Pouco..." (Carbenes in Water: a Mediated Reactivity)", Química – Boletim da Sociedade Portuguesa de Química (Magazine of the Portuguese Chemical Society) , 2010
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/07/25 Augmenting the Reactions’ Portfolio of Quinic Acid Encontro Nacional da SQP
Sociedade Portuguesa de Química (Aveiro, Portugal)
2023/01/26 Phenolic Mannich bases as antibacterials agents for Staphylococcus aureus COST action CA21145, European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (EURESTOP), 1st Meeting
(Lisbon, Portugal)
2021/09/03 Chirons from Deoxygenation of Quinic Acid. International Symposium on Synthesis and Catalysis 2021
(Évora, Portugal)
2021/07/15 Deoxygenation of quinic acid towards new chirons for divergent syntheses XXVII National Meeting of the Portuguese Society of Chemistry
Sociedade Portuguesa de Química (Braga, Portugal)
2021/07/07 Quinic acid chirons by Stereoselective Borane-catalyzed Cleavage of C(sp3)–O Bonds Laboratório Associado para a Química Verde Webinars
Laboratório Associado para a Química Verde (Portugal)
2021/04/14 Quinic acid chirons by Stereoselective Borane-catalyzed Cleavage of C(sp3)–O Bonds ACS Spring 2021
American Chemical Society (United States)
2020/01/29 A Multicomponent Reaction, a Chlorosilane and Bacteria - Synthesis and Function of Aminoalkylphenols Conferências do DQ
Department of Chemistry University of Aveiro (Portugal)
2017 Induction of cell cycle arrest and apoptosis of glioma cancer stem cells. 3rd Annual Finnish Symposium on Brain Tumors
(Finland)
2017 Antibacterial and antitumor properties of alkylaminophenols derived from Petasis borono-Mannich multicomponent reaction Challenging organic syntheses inspired by nature – from natural products chemistry to drug discovery
COST action CM1407 (Portugal)
2017 Synthesis of new acylsilanes Winter School 2017, Suomen Synteettisen Kemian Seura
Suomen Synteettisen Kemian (Finland)
2017 Protection of 1,2-decanediol Winter School 2017, Suomen Synteettisen Kemian Seura
Suomen Synteettisen Kemian (Finland)
2017 Petasis borono-Mannich multicomponent reaction for preparation of biologically active alkylaminophenols Lecture for Medicinal Chemistry course students
Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa (Portugal)
2016 Preparation of chlorosilyl hydrides for deoxygenation of diols Deoxygenation mini symposium
Åbon Akademi (Finland)
2015 Petasis Borono-Mannich Reactions in Glycerol 19th European Symposium in Organic Chemistry
(Portugal)
2015 Petasis borono Mannich reaction in non-conventional solvent media Research Seminars
University of Jyväskylä (Finland)
2013 Catalysts for Aqueous Asymmetric Intramolecular C-H insertion 10th National Meeting of Organic Chemistry of the Portuguese Society of Chemistry
Portuguese Society of Chemistry
2013 Enantioselective modification of oxindole derivatives: aminooxygenation and syntheses of spirooxindoles Komppa Symposium, 13th Spring Meeting of the Finnish Society for Synthetic Chemistry
Finnish Society for Synthetic Chemistry (Finland)
2011 Enantioselective Syntheses of Spirocyclopenteneoxindoles by a Phosphine-Catalyzed [3+2] Cycloaddition Reaction XXII National Meeting of the Portuguese Society of Chemistry
Portuguese Society of Chemistry (Portugal)
2005 Stereoselective synthesis of lactams by Rh(II) catalyzed Intramolecular C-H insertion of diazo compounds 6th National Meeting of Organic Chemistry of the Portuguese Society of Chemistry
Portuguese Society of Chemistry (Portugal)
2005 Rh(II) catalyzed intramolecular C-H insertion of diazo substrates in water 2nd International Conference on Green and Sustainable Chemistry and 9th Annual Green Chemistry and Engineering Conference
(United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/11 - Current Exploring the Synthetic Potential of Bis(silyl)peroxides
Supervisor
 Química (PhD)
Universidade de Aveiro, Portugal
2023/09 - Current Photocatalytic transformations of Quinic Acid
Supervisor
 Química (Master)
Universidade de Aveiro, Portugal
2023/09 - Current Synthesis and modification of alkylaminophenols and biological evaluation of glioblastoma multiforme antitumoral activity
Supervisor
 Bioquímica (Master)
Universidade de Aveiro, Portugal
2022/06 - Current Borrowing Hydrogen Amination of Quinic Acid: Catalytic and Mechanistic Studies
Co-supervisor
 Chemistry (PhD)
Universidade de Aveiro, Portugal
2022/04 - Current Augmenting the biological properties of alkylphenols by design and synthesis of novel phenol-alkaloid chimerics
Co-supervisor
 Sustainable Chemistry (PhD)
Universidade de Aveiro, Portugal
2020/10/30 - Current Sustainable methods for oxidation of Quinic Acid
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/03 - 2023/07 Synthesis of quinic acid derivatives for potential inhibition of a-glucosidase enzyme
Co-supervisor
 Bioquímica (Degree)
Universidade de Aveiro, Portugal
2023/03 - 2023/07 Quinic acid as a precursor for bioactive molecules
Supervisor
 Bioquímica (Degree)
Universidade de Aveiro, Portugal
2017/02 - 2023/03/08 Photochemical Reactions of Acylsilanes Towards the Construction of Carbon-Carbon Bonds
Supervisor
Tampereen yliopisto - Hervannan kampus, Finland

Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/03 - 2022/07 Novos agentes anti tumorais derivados de piridina para tratamento de glioblastoma multiforme
Supervisor
 Química (Other)
Universidade de Aveiro, Portugal
2022/02 - 2022/07 Novos agentes anti tumorais derivados de fenóis para tratamento de glioblastoma multiforme
Supervisor of Daniela Branco
 Bioquímica (Other)
Universidade de Aveiro, Portugal
2017/04 - 2021/09/24 Conversion of Biomass-Based Compounds into Added-Value Chemicals
Supervisor
Tampereen yliopisto - Hervannan kampus, Finland
2021/04 - 2021/07 Preparação de Iminas Derivadas de Ácido Quínico
Co-supervisor
 Bioquímica (Other)
Universidade de Aveiro, Portugal
2019/07/01 - 2020/05/20 Grafting of Molecules and Nanoparticles onto Bioactive Glass for Added Functionality,
Co-supervisor
Tampereen yliopisto - Hervannan kampus, Finland
2015/10 - 2019/11/15 Lewis Base-Catalyzed Modification of Ortho-Substituted Phenols
Supervisor of Benedicta Assoah
 Chemistry (PhD)
Tampereen yliopisto - Hervannan kampus, Finland
2018 - 2018 Reactivity study and biological activity of diterpenes from Plectranthus species
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2018 Studies on Deoxygenation of Decane-1,2-Diol Derivatives with Pinacol-Derived Chlorohydrosilane
Supervisor of Aleksi Paakkunainen
Tampereen Teknillinen Yliopisto Kemian ja Biotekniikan Laitos, Finland
2018 - 2018 Aerobic Oxidation of Lithiated 1,3-Dithianes and Dithioacetals
Supervisor
Tampereen Teknillinen Yliopisto Kemian ja Biotekniikan Laitos, Finland
2016 - 2016 In Vitro Preclinical Investigation of Novel Phenol, Indoline, and Morpholine Derivatives as Anticancer Agents
Co-supervisor
Tampereen Teknillinen Yliopisto Kemian ja Biotekniikan Laitos, Finland
2016 - 2016 Base-Catalysed Condensation of Aryl Aldehydes and Valine-Derived Boroxazolidones
Supervisor
Tampereen Teknillinen Yliopisto Kemian ja Biotekniikan Laitos, Finland
2015 - 2015 Studies on Base-Catalyzed Condensation of Benzaldehyde and Boroxazolidones
Supervisor
Tampereen Teknillinen Yliopisto Kemian ja Biotekniikan Laitos, Finland
2014 - 2014 The Petasis-borono Mannich reaction in glycerol
Supervisor
Tampereen Teknillinen Yliopisto Kemian ja Biotekniikan Laitos, Finland

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/06/10 - 2021/06/10 Second Meeting of the Group of Portuguese Chemists Abroad of the Portuguese Chemical Society (2021/06/10)
Conference (Co-organisor)
 Sociedade Portuguesa de Química, Portugal
2019 - 2019 Chairman and organizer of the Group of Chemists Abroad Session at the XXVI National Meeting of the Portuguese Chemical Society (2019/07)
Conference (Other)
 Sociedade Portuguesa de Química, Portugal
2008 - 2008 1st Portuguese Young Chemists Meeting of the Portuguese Society of Chemistry (2008/10/15 - 2008/10/17)
Congress (Co-organisor)
 Universidade de Lisboa Instituto Superior Técnico, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/12/22 Synthesis of thiazolothiazole and porphyrin derivatives and their applications Ana Cerqueira (PhD)
Universidade de Aveiro, Portugal
2023/11/03 Synthesis of bioactive complex structures via valorisation of bio renewable resources Juliana Pereira (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/10/20 New class of protein kinase C modulators: from ethnopharmacological to nanoparticles Vera Isca (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/07/29 Aminal Guanidine-Based Molecules: Synthesis and Application Rafael Alves Rippel (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/07/28 Catalytic Synthesis of Bioactive Nitrogen Heterocycles Amina Moutayakine (PhD)
Universidade de Évora, Portugal
2023/05/30 Exploring Hypervalent Iodine Reagents: A Powerful Tool for Sulfonylation Reactions João Macara (PhD)
Universidade Nova de Lisboa Departamento de Química, Portugal
2022/12/12 Development of Injectable Hydrogels for Application in Tissue Engineering
(Thesis) Main arguer
 Pedro Ouro (Master)
Universidade de Aveiro, Portugal
2022/09/30 Late-Stage oxygenation of active ingredients
(Thesis) Main arguer
 Duarte Clemente (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2022/05/23 New synthetic methodologies under flow conditions as tool for API synthesis
(Thesis) Main arguer
 Lídia Cavaca (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/02/11 Síntese de Compostos Indólicos Ativadores da p53
(Thesis) Main arguer
 Adriana Margarida Duarte e Silva (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/12/20 Chitin and chitosan as reliable templates towards the carbohydrate backbone of bacterial peptidoglycan
(Thesis) Main arguer
 Fausto Queda (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/03/04 Isolation, Synthesis and Nanoencapsulation of Cytotoxic Compounds From Plectranthus spp.
(Thesis) Arguer
 Catarina Alexandra Gonçalves Garcia (PhD)
Universidad de Alcalá de Henares, Spain
2017/06/15 Lamiaceae extracts and compounds for a topical application through nano delivery systems
Thesis Member
 Filipe Jorge da Silva Pereira (PhD)
Universidad de Alcalá de Henares, Spain
2017/04/13 3-Hydroxy-Quinolin-2(1H)-ones, a useful scaffold: Synthesis and biological evaluation
(Thesis) Arguer
 Roberta Paterna (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/12/29 New Synthetic methodologies for the transformation of biomass derived intermediates to valuable molecules
(Thesis) Arguer
 Jaime Coelho (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/07/10 Boronic acids as partners in multicomponent reactions
(Thesis) Arguer
 Francesco Montalbano (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2019 - 2021 Group of Portuguese Chemists Abroad of the Portuguese Chemical Society President and founder

Committee member

Activity description
Role 		Institution / Organization
2022/02 - Current Member of the scientific council of SPOT Nordic- Association for Portuguese Graduate Professionals & Researchers in the Nordic Countries
Other
 SPOT Nordic- Association for Portuguese Graduate Professionals & Researchers in the Nordic Countries, Denmark
2018/09 - Current External member of monitoring committee for PhD studies
Other
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Conference scientific committee

Conference name Conference host
2021/06/10 - Current 2nd Meeting of the Group of Portuguese Chemists Abroad of the Portuguese Chemical Society

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/03 - Current Química Orgânica Engenharia Química (Licenciatura) Universidade de Aveiro, Portugal
2023/09 - 2024/02 Laboratórios Bioquímica - Química Orgânica Bioquímica (Licenciatura) Universidade de Aveiro, Portugal
2023/08 - 2024/02 Fundamentos de Química Engenharia Física (Licenciatura) Universidade de Aveiro, Portugal
2023/12 - 2023/12 Química Medicinal Química Universidade de Aveiro, Portugal
2023/03 - 2023/07 Química Orgânica I Química (Licenciatura) Universidade de Aveiro, Portugal
2020/02 - 2023/07 Química Biorgânica Biotecnologia (Licenciatura) Universidade de Aveiro, Portugal
2021/10 - 2022/02 Laboratório Q4 Laboratório Q4 (Bachelor) Universidade de Aveiro, Portugal
2020/10 - 2021/02 Elementos Química Física (Mestrado integrado) Universidade de Aveiro, Portugal
2020/10 - 2021/01 Laboratorios Química Orgânica - Química Física (Mestrado integrado) Universidade de Aveiro, Portugal
2017 - 2019 Bioorganic Chemistry (kandidaatti) Tampereen yliopisto - Hervannan kampus, Finland
2013 - 2019 Organic Chemistry II (kandidaatti) Tampereen yliopisto - Hervannan kampus, Finland
2013 - 2015 Asymmetric Chemistry (kandidaatti) Tampereen yliopisto - Hervannan kampus, Finland
2012 - 2015 Organic Chemistry Laboratory 2 (kandidaatti) Tampereen yliopisto - Hervannan kampus, Finland
2012 - 2013 Advanced Organic Chemistry (kandidaatti) Tampereen yliopisto - Hervannan kampus, Finland
2011 - 2013 Organic Chemistry I (Teaching Assistant) (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2012 Organic Chemistry II (Teaching Assistant) (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2009 Organic Chemistry (Teaching Assistant) (Bacharelato) Egas Moniz Cooperativa de Ensino Superior CRL, Portugal
2008 - 2009 Organic Chemistry I (Teaching Assistant) (Mestrado integrado) Escola Superior de Saúde Egas Moniz, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2020/06/16 - Current Evaluator of a proposal for Generic Call for Proposals 2020 from "Agence nationale de la recherche", France
Evaluator
2018/11 - 2018/11 Reviewer for Regular 2019 grant competition
Evaluator
 Comisión Nacional de Investigación Científica y Tecnológica Fondo Nacional de Desarrollo Científico y Tecnológico, Chile
2016 - 2016 External evaluator for Promotion of a Senior Teaching fellow to Principal Teaching Fellow in Chemistry
Evaluator
 University of Southampton, United Kingdom

Other jury / evaluation

Activity description Institution / Organization
2023/12/20 - Current Pre examiner of PhD thesis: Synthesis and Characterization of ß-Lactams and a-Benzoyloxy Esters Using Different Carbene Sources Catalyzed by Transition Metal Complexes Pondicherry University, India
2023/06/02 - Current Pre-examiner of thesis: Evaluation of Biocompatibility and Therapeutic Application of Gold Nanoparticles Phyto-fabricated Through Clerodin Enriched Clerodendrum infortunatum Linn Leaf Extract SRM Institute of Science and Technology (Deemed to be University) College of Engineering & Technology, India
2012 - Current Archiv Der Pharmazie; Arabian J. Chem.; Catalysts; Chem. Commun.; Chem. Rev.; ChemistrySelect; ChemCatChem; ChemMedChem; Chinese J. Chem.; Chirality; Curr. Catal.; Curr. Green Chem.; Curr. Org. Chem.; Curr. Org. Synth..; Eur. J. Org. Chem.; Fuel; Helvet. Chim. Acta; J. Chem. Ed.; J. Photochem. Photobiol. B; J. Org. Chem.; Mini Rev. Med. Chem; Molecules; Monat. Chemie; Nat. Prod. Commun.; Org. Lett.; Phytochem. Lett.; RSC Adv.; SynOpen; Synthesis; Tetrahedron; Tetrahedron Lett.
2016/03 - 2016/03 Evaluation of "Biological Chirality" book proposal by Elsevier Elsevier BV, Netherlands
Distinctions

Award

2010 Menção Honrosa do Prémio Químicos Jovens
Sociedade Portuguesa de Química, Portugal

Title

2015 Academy Research Fellow
Suomen Akatemia, Finland
2015 Adjunct Professor (Dosentti) in Sustainable Synthetic Organic Chemistry
Tampereen Teknillinen Yliopisto Kemian ja Biotekniikan Laitos, Finland

Other distinction

2022 Outstanding Reviewer RSC Medicinal Chemistry
Royal Society of Chemistry, United Kingdom