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Carolina Silva Marques. Completed the Doutoramento in Chemistry in 2013/04/05 by Universidade de Évora, Mestrado in Master¿s in science in Applied Chemistry in 2008/07/11 by Universidade de Évora and Licenciatura in Graduation in Chemistry in 2005/11/15 by Universidade de Évora. Is Contracted Researcher in Universidade de Évora and Invited Assistant Professor in Universidade de Évora Departamento de Química. Published 44 articles in journals. Has 3 section(s) of books and 2 book(s). Has 11 patent(s) registered. Organized 5 event(s). Participated in 4 event(s). Co-supervised 2 MSc dissertation(s). Supervised 5 work(s) of course completion of LSc/BSc e co-supervised 2. Has received 2 awards and/or honors. Participates and/or participated as Post-doc Fellow in 1 project(s), Principal investigator in 4 project(s), Research Fellow in 3 project(s) and Researcher in 8 project(s). Works in the area(s) of Exact Sciences with emphasis on Chemical Sciences with emphasis on Organic Chemistry and Exact Sciences with emphasis on Chemical Sciences with emphasis on Organic Chemistry. In their professional activities interacted with 130 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: drug design; hit optimization; biologically active compounds; lead generation; asymmetric synthesis; catalysis; transition-metal catalysts; methodology and reactions; Cancer; Multicomponent Reactions; Oxindole; Tyrosine-Kinase; .
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Identification

Personal identification

Full name
Carolina Silva Marques

Citation names

  • Marques, Carolina

Author identifiers

Ciência ID
7B1F-9EA8-30BA
ORCID iD
0000-0003-1697-7871
Google Scholar ID
https://scholar.google.pt/citations?hl=pt-PT&user=ZroMlosAAAAJ&view_op=list_works&gmla=AJsN-F7GXeBDYx1XHekOAxDLvV6kjXBFZ6i8D974oUKZyo3QuViJz2-ehY_BnVf1ccvEZbgvOxuF4uQH_XO8hzlJ5COwGsB_jw
Scopus Author Id
14040402800

Email addresses

  • carolsmarq@uevora.pt (Professional)
  • carolsmarq@gmail.com (Personal)

Telephones

Fax
  • 266745303 (Professional)
Telephone
  • 266745311 (Professional)

Addresses

  • Departamento de Química e Bioquímica | Colégio Luís António Verney, Rua Romão Ramalho, 59, 7000-671, Évora, Évora, Portugal (Professional)
  • Rua Monsenhor José Filipe Mendeiros, lote 2, r/c esquerdo; Quinta da Soeira, 7005-475, Évora, Évora, Portugal (Personal)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2009 - 2013/04/05
Concluded
 Chemistry (Doutoramento)
Major in Organic chemistry
Universidade de Évora, Portugal
"Synthesis and Evaluation of Chiral Phosphine and NHC-Ligands for Heterogenous Asymmetric Catalysis" (THESIS/DISSERTATION)
 19
2007/09 - 2008/07/11
Concluded
 Master’s in science in Applied Chemistry (Mestrado)
Major in Organic Chemistry
Universidade de Évora, Portugal
 17
1999/09 - 2005/11/15
Concluded
 Graduation in Chemistry (Licenciatura)
Major in Reserarch
Universidade de Évora, Portugal
"Síntese estereoselectiva de hidroxiesteres terciários" (THESIS/DISSERTATION)
 14
1999
Concluded
 High-school (Ensino secundário)
Major in Natural-Sciences
Externato Cooperativo da Benedita, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2019/06/03 - Current Contracted Researcher (Research) Universidade de Évora, Portugal
Universidade de Évora, Portugal
(...)
2009 - 2020 Research Assistant (Research) ChiraTecnics, Portugal
Universidade de Évora, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019/09 - Current Invited Assistant Professor (University Teacher) Universidade de Évora Departamento de Química, Portugal
Universidade de Évora, Portugal

Others

Category
Host institution 		Employer
2014/12 - 2019/11/30 Post-doc research fellow Universidade de Évora Centro de Química de Évora, Portugal
Universidade de Évora, Portugal
2013/05/01 - 2013/11/30 Post-doc research fellow Universidade de Évora Centro de Química de Évora, Portugal
Universidade de Évora, Portugal
2009/05/01 - 2013/05/01 PhD research fellow Universidade de Évora Centro de Química de Évora, Portugal
Universidade de Évora, Portugal
2008/05/07 - 2009/03/31 Research fellow Universidade de Lisboa Centro de Química-Física Molecular, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
2006/10/30 - 2007/12/31 Research fellow Universidade de Évora Centro de Química de Évora, Portugal
Universidade de Évora, Portugal
Projects

Grant

Designation Funders
2013/05/01 - 2014/11/30 INMOLFARM-Molecular Innovation and Drug Discovery
ALENT-57-2011-20
Post-doc Fellow
Universidade de Évora Centro de Química de Évora, Portugal
Concluded
2008/05/07 - 2009/03/31 Synthesis and characterization of new and not so new Ionic Liquids
PTDC/QUI/66826/2006
Research Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/05/07 - 2009/03/31 High Pressure CO2 - Induced melting of salts
PTDC/QUI/70383/2006
Research Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006/10/30 - 2007/12/31 Synthesis of New Chiral Ligands with Phosphorous and Nitrogen to apply in Homogeneous and Heterogeneous Catalytic Asymmetric Reactions
POCI/QUI/55779/2004
Research Fellow
Universidade de Évora Centro de Química de Évora, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2006/10 - 2007/12 Synthesis of New Chiral Ligands with Phosphorous and Nitrogen to apply in Homogeneous and Heterogeneous Catalytic Asymmetric Reactions
POCI/QUI/55779/2004
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2023/01/01 - 2024/06/30 Engaging Libraries of Promising Oxindoles as Tyrosine-Kinase InhibitorS in Cancer Target Therapy
2022.02910.PTDC
10.54499/2022.02910.PTDC
Principal investigator
Universidade de Évora, Portugal

Universidad de La Laguna, Spain

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2022 AmOxH2L: Amino-Oxindoles: Hit to Lead optimization in Drug Discovery in Alzheimer’s Disease
2022.03847.CEECIND
Researcher
Fundação para a Ciência e a Tecnologia
Not funded
2021 - 2021 SMIBOH: Small-Molecule-Isatin-Based-Oxindole-Hybrids as multitarget drugs to treat Alzheimer’s disease
2021.00662.CEECIND
Researcher
Fundação para a Ciência e a Tecnologia
Not funded
2020 - 2020 New Isatin-Oxindole-Triazole Hybrids: Multi-target Directed Small-Molecules as a Disease-Modifying approach for Alzheimer’s Disease
2020.02428.CEECIND
Researcher
University of Évora-Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, Portugal
 Fundação para a Ciência e a Tecnologia
Not funded
2018 - 2018 Small Molecules - Great Achievements! New Isatin-Oxindole-Triazole Hybrids as Cholinesterase Inhibitors and Anti-Cancer Drugs - Hit Refinement in Multi-Targeting Drug Design
CEECIND/02104/2018
Researcher
Universidade de Évora Centro de Química de Évora, Portugal
 Fundação para a Ciência e a Tecnologia
Not funded
2017 - 2017 Enantioselective Synthesis of New Small Molecule Candidates for Targeted Cancer Therapy
CEECIND/03226/2017
Researcher
Universidade de Évora Centro de Química de Évora, Portugal
 Fundação para a Ciência e a Tecnologia
Not funded

Other

Designation Funders
2023/03/01 - 2026/02/28 ConChiMOL: New Structurally Contorted and Chiral Molecules for Optoeletronic Applications
2022.01391.PTDC
Researcher
University of Évora-Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2021 MHICANO: Molecular Hybridization in Cryptosporidiosis: Attractive New Oxindoles in Veterinary Medicines
EXPL/QUI-QOR/0625/2021
Principal investigator
Fundação para a Ciência e a Tecnologia
Not funded
2021 - 2021 DOPELX: Developing Novel Polyamides for Application in Optoelectronic Devices
PTDC/QUI-QOR/1392/2021
Researcher
Fundação para a Ciência e a Tecnologia
Not funded
2020 - 2020 Engaging New Oxindoles in Veterinary Medicines_Insides in Cryptosporidiosis
PTDC/QUI-QOR/1771/2020
Principal investigator
University of Évora-Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, Portugal
 Fundação para a Ciência e a Tecnologia
Not funded
2020 - 2020 SMOLSEM: Development of New Small Molecules with Optoeletronic Properties
PTDC/CTM/1168/2020
Researcher
University of Évora-Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, Portugal
 Fundação para a Ciência e a Tecnologia
Not funded
2017 - 2017 Innovative design and synthesis of new spiro-isoquinolinone derivatives for targeted cancer therapy
02/SAICT/2017; Projeto 32632
Principal investigator
Universidade de Évora Centro de Química de Évora, Portugal
 Fundação para a Ciência e a Tecnologia
Not funded
Outputs

Publications

Book
  1. Marques, Carolina; Anthony J. Burke; Nicholas J. Turner; Gesine J. Hermann. Active Pharmaceutical Ingredients in Synthesis. Germany: Wiley-VCH Verlag GmbH & Co. KGaA. 2018.
    Published • 10.1002/9783527807253
  2. Burke, A.J.; Marques, C.S.. Catalytic Arylation Methods: From the Academic Lab to Industrial Processes. Germany. 2015.
    Published • 10.1002/9783527672707
Book chapter
  1. Marques, Carolina. "Chapter 3: Soil remediation techniques". In Bioremediation of petroleum contaminated sediment/soil. Elsevier, 2023.
    Submitted
  2. Marques, Carolina; Carreiro, Elisabete P.; 8B14-DCB5-79CD. Corresponding author: Marques, Carolina. "Chapter 7: Multicomponent Synthesis of Heterocycles". In Heterocycles - Synthesis, Catalysis, Sustainability and Characterization. Wiley-VCH, 2022.
    Published • 10.1002/9783527832002.ch7
  3. Marques, Carolina. "Synthesis of Ethyl Mandelate through a Rhodium-Catalyzed Arylation Reaction with Ethyl Glyoxylate and Phenylboronic Acid". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. Cambridge: RSC Publications, 2017.
    Published
Conference abstract
  1. Marques, Carolina. "N-1,2,3-Triazole-Isatin derivatives in lymphoma cell lines". Paper presented in 34th EORTC-NCI-AACR Symposium, Poster Session Cytotoxics (including Antimetabolites, Anthracyclin, Alkylating agents, Aurora kinases, Polo-like kinase, Topos- isomerase inhibitors, Tubulin-binding compounds), 2022.
    10.1016/S0959-8049(22)00976-5
Conference poster
  1. Marques, Carolina; Ana Margarida Charrua Janeiro. Corresponding author: Ana Margarida Charrua Janeiro. "Using the Passerini Multicomponent Reaction as a Tool to Access Small- libraries of Oxindole-type Hybrids as Promising Anticancer Agents". Paper presented in 15th National Organic Chemistry Meeting and 8th National Medicinal Chemistry Meeting, 2024.
  2. Marques, Carolina. "ELPIS: Engaging Libraries of Promising Oxindoles as Tyrosine-Kinase InhibitorS in Cancer Target Therapy". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat2023), 2023.
  3. Marques, Carolina. "N-1,2,3-Triazole-Isatin derivatives in lymphoma cell lines". Paper presented in 34th EORTC/AACR/NCI symposium, 2022.
  4. Marques, Carolina. "Sustainability Meets Structural Diversity: Isatin-Based Multicomponent Reactions (MCR)". Paper presented in Coimbra Chemistry Centre Day 2021, 2021.
  5. Marques, Carolina. "Isatin as a Central “Puzzle Piece” for Multicomponent Reactions (MCRs)". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat2021), 2021.
  6. Marques, Carolina. Corresponding author: Marques, Carolina. "Molecular Hybridization as an Efficient Strategy in the Design and Synthesis of Promising Isatin-based Oxindole Derivatives". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat2021), 2021.
  7. Marques, Carolina. "Rh Catalytic Synthesis of Chiral 3-Amino-3-aryl-2-oxindoles from Isatin-derived N-Boc-protected Ketimines". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat2021), 2021.
  8. Marques, Carolina. "New tryptanthrin-based Petasis adducts – synthesis and biological activity evaluation". Paper presented in EFMC-ISMC 2021 XXVI EFMC International Symposium on Medicinal Chemistry, 2021.
  9. Marques, Carolina. "The Potential of Heterocyclic Scaffolds as Building Blocks". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat2019), 2019.
  10. Marques, Carolina. "Studies on the Direct Reductive Amination of Chromanone derivatives: New targets for Neurodegenerative Diseases". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat2019), 2019.
  11. Marques, Carolina. "Novel Precious Metal Catalyzed Processes for Bicyclic Ring Synthesis: Accessing 3-Aminooxindoles and 3,3-Dimethylchroman-4-ols". Paper presented in The 14th International Kyoto Conference on New Aspects of Organic Chemistry – IKCOC-14, 2018.
  12. Marques, Carolina. "Oxindoles as Privileged Structure Scaffolds for Drug Design". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat2017), 2017.
  13. Marques, Carolina. "The Search for New Anti-Cancer Molecules: Catalytic Synthesis of Novel Chiral Oxindole Derivative". Paper presented in 15º Encontro Nacional da SPQ, 2017.
  14. Marques, Carolina. "New Synthetic Route to Chiral Benzocycloalkanol Molecules for treating Alzheimer’s disease". Paper presented in 5th Portuguese Young Chemists Meeting (PYCheM) and 1st European Young Chemists, 2016.
  15. Marques, Carolina. "Synthesis of a Library of Isoquinolinone and Azepinone Derivatives using a Metal-Catalyzed Intramolecular Cyclization Reaction as the Key Step". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat), 2015.
  16. Marques, Carolina. "A Novel Catalytic Route to Dibenzodiazepines involving Buchwald- Hartwig Coupling". Paper presented in International Symposium on Synthesis and Catalysis (ISySyCat), 2015.
  17. Marques, Carolina. "The Role of Cholinesterases in Alzheimer’s disease: Screening of Target Compounds". Paper presented in 12th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (AD/PDTM 2015), 2015.
  18. Marques, Carolina. "Antioxidant and antimicrobial activities of arylamide-acetals derivates: Potential drugs for neurodegenerative diseases". Paper presented in 18º Congresso da Sociedade Portuguesa de Bioquímica, 2014.
  19. Marques, Carolina. "The role of Acetylcholinesterase in Alzheimer’s disease: Enzymatic inhibition studies". Paper presented in 18º Congresso da Sociedade Portuguesa de Bioquímica, 2014.
  20. Marques, Carolina. "Computational study for the palladium-catalyzed dibenzodiazepine synthesis". Paper presented in CRC-SU Joint International Symposium on Chemical Theory for Complex Systems, 2014.
  21. Marques, Carolina. "Innovative and Expeditious Intramolecular Metal-Catalyzed Reaction to afford new Chiral Drug Analogues". Paper presented in EFMC-YMCS, 1st EFMC-Young Medicinal Chemist Symposium, 2014.
  22. Marques, Carolina. "New Chiral Analogues for Neurodegenerative Diseases: The power of metal catalysis". Paper presented in EFMC-ISMC 2014 - XXIII International Symposium on Medicinal Chemistry, 2014.
  23. Marques, Carolina. "Innovative sequential catalytic imine arylation/Suzuki-Miyaura coupling with arylboron reagents: A powerful route to bioactive compounds". Paper presented in 15th Tetrahedron Symposium, Challenges in Bioorganic & Organic Chemistry, 2014.
  24. Marques, Carolina. "Versatile Innovative Metal Catalyzed Couplings - Modular Approach to Rasagiline Analogues". Paper presented in 15th Tetrahedron Symposium, Challenges in Bioorganic & Organic Chemistry, 2014.
  25. Marques, Carolina. "Ligand/Additive Control Over ß-Hydride Elimination: Towards Bioactive Chiral Cycloalkanols". Paper presented in 15th Tetrahedron Symposium, Challenges in Bioorganic & Organic Chemistry, 2014.
  26. Marques, Carolina. "BolmAr: Borylation(Catalytic)-Imination-Arylation(Catalytic) - A new Synthetic Approach to promising Alzheimer and Parkinson Drugs". Paper presented in 10º Encontro Nacional de Química Orgânica e 1º Simpósio Luso-Brasileiro, 2013.
  27. Marques, Carolina. "BorArAm - Catalytic Asymmetric Arylation Cyclizations: A New Route to Chiral Bicyclic Amines". Paper presented in 10º Encontro Nacional de Química Orgânica e 1º Simpósio Luso-Brasileiro, 2013.
  28. Marques, Carolina. "INMOLFARM - Nova família de fármacos para doenças neurodegenerativas". Paper presented in Jornadas DQUI 2013, 2013.
  29. Marques, Carolina. "Rhodium Catalyzed Enantioselective Arylation of Glyoxylate Derivatives using Organoboron Reagents". Paper presented in 10º Encontro Nacional de Química Orgânica e 1º Simpósio Luso-Brasileiro, 2013.
  30. Marques, Carolina. "Multi-Product Synthesis via Modular Catalytic Arylation". Paper presented in 6th Spanish-Portuguese-Japanese Organic Chemistry Symposium, 2012.
  31. Marques, Carolina. "Catalytic Asymmetric Arylation of N-Tosylimino Esters of Ethyl Glyoxalate and their Application in the Synthesis of Unnatural a-Amino Acids, using Rhodium Catalysts". Paper presented in 13th Tetrahedron Conference, 2012.
  32. Marques, Carolina. "Approaches to the Synthesis of Chiral Amines - Catalytic Asymmetric Arylation of Imines using Boron Reagents with Metal Catalysts". Paper presented in 3rd EuCheMS Chemistry Congress, 2010.
  33. Marques, Carolina. "Novel chiral catalysts for Homogeneous and Heterogeneous Asymmetric Synthesis". Paper presented in OMCOS 15 - Symposium on Organometallic Chemistry Directed towards Organic Synthesis, 2009.
  34. Marques, Carolina. "The Catalytic Tandem Oxidation/Benzilic Ester Rearrangement: An Expeditious Approach to the Synthesis of Tertiary a-Hydroxyesters". Paper presented in 20º Encontro Nacional da Sociedade Portuguesa de Química, 2006.
  35. Marques, Carolina. "Síntese Estéreo-Selectiva de a-Hidroxiésteres Terciários a partir de a-Hidroxicetonas". Paper presented in 6º Encontro Nacional de Química Orgânica, 2005.
  36. Marques, Carolina. "Synthesis and Evaluation of Chiral Nitrogen Containing Bidentate Ligands for Catalytic Asymmetric Synthesis". Paper presented in 5th International Symposium of Transition Metals in Organic Synthesis, 2004.
Edited book
  1. Marques, Carolina. Abstract book of the International Symposium on Synthesis and Catalysis (ISySyCat_2023). Portugal. 2023.
    Published
  2. Marques, Carolina. Corresponding author: Marques, Carolina. Abstract book of the International Symposium on Synthesis and Catalysis (ISySyCat_2021). Portugal: Cromotema. 2021.
    Published • Editor
  3. Marques, Carolina; Elisabete P. Carreiro; Anthony J. Burke. Corresponding author: Marques, Carolina. Abstract book of the International Symposium on Synthesis and Catalysis (ISySyCat_2019). Portugal: Cromotema. 2019.
    Published • Editor
  4. Marques, Carolina; Elisabete P. Carreiro; Anthony J. Burke. Corresponding author: Marques, Carolina. Abstract book of the International Symposium on Synthesis and Catalysis (ISySyCat_2017). Portugal: Cromotema. 2017.
    Published • Editor
  5. Marques, Carolina; Elisabete P. Carreiro; Anthony J. Burke. Corresponding author: Marques, Carolina. Abstract book of the International Symposium on Synthesis and Catalysis (ISySyCat_2015). Portugal: Cromotema. 2015.
    Published • Editor
Journal article
  1. Marques, Carolina. "HOXB7 epigenetic regulation in breast cancer cells". The Journal of Gene Medicine (2024):
    Submitted
  2. Hofmanova, Tereza; Marques, Carolina; García-Sosa, Alfonso T.; López, Óscar; Leitzbach, Luisa; Carreiro, Elisabete P.; González-Bakker, Aday; et al. "N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer’s Disease". Results in Chemistry 6 (2023): 101032. http://dx.doi.org/10.1016/j.rechem.2023.101032.
    10.1016/j.rechem.2023.101032
  3. Marques, Carolina; Brandão, Pedro. Corresponding author: Marques, Carolina. "The Asymmetric Petasis Borono-Mannich Reaction: Insights on the Last 15 Years". Catalysts 13 6 (2023): 1022. http://dx.doi.org/10.3390/catal13061022.
    10.3390/catal13061022
  4. Marques, Carolina; Aday González-Bakker; José M. Padrón; Anthony J. Burke. Corresponding author: Marques, Carolina. "Easy access to Ugi-derived isatin-peptoids and their potential as small-molecule anticancer agents". New Journal of Chemistry (2023): https://doi.org/10.1039/D2NJ03627D.
    10.1039/D2NJ03627D
  5. Marques, Carolina. "N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer’s Disease". Bioorganic Chemistry (2023):
    Under revision
  6. Moutayakine, Amina; Marques, Carolina; López, Óscar; Bagetta, Donatella; Leitzbach, Luisa; Hagenow, Stefanie; Carreiro, Elisabete P.; et al. "Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer’s disease". Bioorganic & Medicinal Chemistry 68 (2022): 116807. http://dx.doi.org/10.1016/j.bmc.2022.116807.
    10.1016/j.bmc.2022.116807
  7. Marques, Carolina; Óscar López; Luisa Leitzbach; José G. Fernández-Bolaños; Holger Stark; Anthony J. Burke. Corresponding author: Marques, Carolina. "Survey of New, Small-Molecule Isatin-Based Oxindole Hybrids as Multi-Targeted Drugs for the Treatment of Alzheimer’s Disease". Synthesis (2022): https://doi.org/10.1055/s-0041-1737343.
    10.1055/s-0041-1737343
  8. Marques, Carolina; Anthony J. Burke. Corresponding author: Marques, Carolina. "Isatina: “Bloco de Construção” Promissor no Desenvolvimento de Novos Fármacos". Boletim da Sociedade Portuguesa de Química (2022): 25. http://dx.doi.org/10.52590/m3.p704.a30002603.
    10.52590/m3.p704.a30002603
  9. Natalia Busto; Joana Leitão-Castro; Alfonso T. García-Sosa; Francisco Cadete; Carolina S. Marques; Renata Freitas; Anthony J. Burke. "N-1,2,3-Triazole–isatin derivatives: anti-proliferation effects and target identification in solid tumour cell lines". RSC Medicinal Chemistry (2022): https://doi.org/10.1039/D2MD00044J.
    10.1039/D2MD00044J
  10. Brandão, Pedro; Marques, Carolinal S.; Carreiro, Elisabete P.; Pineiro, M.; Burke, Anthony J.. "Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity". The Chemical Record (2021): http://dx.doi.org/10.1002/tcr.202000167.
    10.1002/tcr.202000167
  11. Brandão, Pedro; Marques, Carolina; Pinto, Eugénia; Pineiro, Marta; Burke, Anthony J.. "Petasis adducts of tryptanthrin – synthesis, biological activity evaluation and druglikeness assessment". New Journal of Chemistry (2021): http://dx.doi.org/10.1039/d1nj02079j.
    10.1039/d1nj02079j
  12. Brandão, Pedro; Marques, Carolina; Burke, Anthony J.; Pineiro, Marta. "The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules". European Journal of Medicinal Chemistry 211 (2020): 113102. http://dx.doi.org/10.1016/j.ejmech.2020.113102.
    Published • 10.1016/j.ejmech.2020.113102
  13. Marques, Carolina S.; Cruz, Hugo; Lawrence, Simon E.; Gago, Sandra; Prates Ramalho, João P.; Morgado, Jorge; Branco, Luís C.; Burke, Anthony J.. "Ambipolar pentacyclic diamides with interesting electrochemical and optoelectronic properties". Chemical Communications 56 (2020): 14893-14896. http://dx.doi.org/10.1039/d0cc04629a.
    Published • 10.1039/d0cc04629a
  14. Marques, Carolina. Corresponding author: Marques, Carolina. "Accessing new 5-a-(3,3-Disubstituted Oxindole) -Benzylamine Derivatives from Isatin: Stereoselective Organocatalytic Three Component Petasis Reaction". European Journal of Organic Chemistry (2020): https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.202000334.
    Accepted • 10.1002/ejoc.202000334
  15. Marques, Carolina S.; López, Óscar; Bagetta, Donatella; Carreiro, Elisabete P.; Petralla, Sabrina; Bartolini, Manuela; Hoffmann, Matthias; et al. "N-1,2,3-triazole-isatin derivatives for cholinesterase and ß-amyloid aggregation inhibition: A comprehensive bioassay study". Bioorganic Chemistry 98 (2020): 103753. http://dx.doi.org/10.1016/j.bioorg.2020.103753.
    10.1016/j.bioorg.2020.103753
  16. Viana, Hugo; Marques, Carolina; Correia, Camille A.; Gilmore, Kerry; Galvão, Luís; Vieira, Letícia; Seeberger, Peter H.; Burke, Anthony J.. Corresponding author: Marques, Carolina. "Novel Palladium-Catalyzed Intramolecular Addition of Aryl Bromides to Aldehydes as Key to the Synthesis of 3,3-Dimethylchroman-4-ones and 3,3-Dimethylchroman-4-ols". ChemistrySelect 3 40 (2018): 11333-11338. http://dx.doi.org/10.1002/slct.201802889.
    Accepted • 10.1002/slct.201802889
  17. Marques, Carolina; Anthony Burke; Simon Lawrence. Corresponding author: Marques, Carolina. "Pd-Catalyzed One-Pot Borylation/Intramolecular Asymmetric Arylation on a-Ketiminoamides: Innovative Approach to Chiral 3-Amino-2-oxindoles". Synlett (2018): https://doi.org/10.1055/s-0036-1590940.
    10.1055/s-0036-1590940
  18. Marques, Carolina; Anthony J. Burke. Corresponding author: Marques, Carolina. "Enantioselective Rhodium(I)-Catalyzed Additions of Arylboronic Acids to N -1,2,3-Triazole-Isatin Derivatives: Accessing N -(1,2,3-Triazolmethyl)-3-hydroxy-3-aryloxindoles". ChemCatChem 8 22 (2016): 3518-3526. https://doi.org/10.1002%2Fcctc.201600901.
    10.1002/cctc.201600901
  19. Totobenazara, Jane; Bacalhau, Patrícia; Juan, Amor A. San; Marques, Carolina; Fernandes, Luís; Goth, Albertino; Caldeira, A. Teresa; Martins, Rosário; Burke, Anthony J.. "Design, Synthesis and Bioassays of 3-Substituted-3-Hydroxyoxindoles for Cholinesterase Inhibition". ChemistrySelect 1 13 (2016): 3580-3588. http://dx.doi.org/10.1002/slct.201600932.
    10.1002/slct.201600932
  20. Bacalhau, P.; San Juan, A.A.; Marques, C.S.; Peixoto, D.; Goth, A.; Guarda, C.; Silva, M.; et al. "New cholinesterase inhibitors for Alzheimer's disease: Structure Activity Studies (SARs) and molecular docking of isoquinolone and azepanone derivatives". Bioorganic Chemistry 67 (2016): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988982023&partnerID=MN8TOARS.
    10.1016/j.bioorg.2016.05.004
  21. Marques, Carolina; Burke, A.J.. Corresponding author: Marques, Carolina. "Modular Catalytic Synthesis of 3-Amino-3-aryl-2-oxindoles: Rh Catalysis with Isatin-Derived N-Boc-Protected Ketimines". European Journal of Organic Chemistry 2016 4 (2016): 806-812. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952684751&partnerID=MN8TOARS.
    10.1002/ejoc.201501399
  22. Peixoto, D.; Locati, A.; Marques, C.S.; Goth, A.; Ramalho, J.P.P.; Burke, A.J.. "A catalytic route to dibenzodiazepines involving Buchwald-Hartwig coupling: Reaction scope and mechanistic consideration". RSC Advances 5 121 (2015): 99990-99999. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948440612&partnerID=MN8TOARS.
    10.1039/c5ra19599c
  23. Marques, Carolina; Peixoto, D.; Burke, A.J.. Corresponding author: Marques, Carolina. "Transition-metal-catalyzed intramolecular cyclization of amido(hetero)arylboronic acid aldehydes to isoquinolinones and derivatives". RSC Advances 5 26 (2015): 20108-20114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923875817&partnerID=MN8TOARS.
    10.1039/c5ra00404g
  24. Marques, Carolina; Locati, A.; Prates Ramalho, J.P.; Burke, A.J.. Corresponding author: Marques, Carolina. "Palladium catalysed sequential imine arylation/Suzuki-Miyaura coupling: Synthesis of a-(biarylyl)benzylamines". Tetrahedron 71 21 (2015): 3314-3324. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937762500&partnerID=MN8TOARS.
    10.1016/j.tet.2015.03.105
  25. Marques, C.S.; Dindaroglu, M.; Schmalz, H.-G.; Burke, A.J.. "Asymmetric catalytic arylation of ethyl glyoxylate using organoboron reagents and Rh(i)-phosphane and phosphane-phosphite catalysts". RSC Advances 4 12 (2014): 6035-6041. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892151211&partnerID=MN8TOARS.
    10.1039/c3ra47000h
  26. Cruz, M.M.; Borges, R.P.; Godinho, M.; Marques, C.S.; Langa, E.; Ribeiro, A.P.C.; Lourenço, M.J.V.; et al. "Thermophysical and magnetic studies of two paramagnetic liquid salts: [C4mim][FeCl4] and [P66614][FeCl4]". Fluid Phase Equilibria 350 (2013): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878667303&partnerID=MN8TOARS.
    10.1016/j.fluid.2013.03.001
  27. Marques, C.S.; Burke, A.J.. "Ethyl 2,2-bis(4-methylphenylsulfonamido)acetate to aromatic a-amino acids: Stable substrates for catalytic arylation reactions". Tetrahedron 69 47 (2013): 10091-10097. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885951119&partnerID=MN8TOARS.
    10.1016/j.tet.2013.09.053
  28. Marques, C.S.; Burke, A.J.. "Enantioselective catalytic synthesis of ethyl mandelate derivatives using Rh(I)-NHC catalysts and organoboron reagents". Tetrahedron Asymmetry 24 11 (2013): 628-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878563445&partnerID=MN8TOARS.
    10.1016/j.tetasy.2013.04.011
  29. Ventura, S.P.M.; Marques, C.S.; Rosatella, A.A.; Afonso, C.A.M.; Gonçalves, F.; Coutinho, J.A.P.. "Toxicity assessment of various ionic liquid families towards Vibrio fischeri marine bacteria". Ecotoxicology and Environmental Safety 76 1 (2012): 162-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-81955161913&partnerID=MN8TOARS.
    10.1016/j.ecoenv.2011.10.006
  30. Diogo, J.C.F.; Caetano, F.J.P.; Fareleira, J.M.N.A.; Wakeham, W.A.; Afonso, C.A.M.; Marques, C.S.. "Viscosity measurements of the ionic liquid trihexyl(tetradecyl)phosphonium dicyanamide [P 6,6,6,14][dca] using the vibrating wire technique". Journal of Chemical and Engineering Data 57 4 (2012): 1015-1025. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859762689&partnerID=MN8TOARS.
    10.1021/je200830j
  31. Marques, C.S.; Burke, A.J.. "Expeditious and novel synthesis of a-hydroxyesters via rhodium-NHC catalyzed arylation of ethyl glyoxalate". Tetrahedron 68 35 (2012): 7211-7216. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863847832&partnerID=MN8TOARS.
    10.1016/j.tet.2012.05.129
  32. Marques, C.S.; Burke, A.J.. "Chiral diphosphane- and NHC-containing ruthenium catalysts for the catalytic asymmetric arylation of aldimines with organoboron reagents". European Journal of Organic Chemistry 22 (2012): 4232-4239. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864186645&partnerID=MN8TOARS.
    10.1002/ejoc.201200556
  33. Marques, C.S.; Burke, A.J.. "Advances in the Catalytic Asymmetric Arylation of Imines using Organoboron Reagents: An Approach to Chiral Arylamines". ChemCatChem 3 4 (2011): 635-645. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051581714&partnerID=MN8TOARS.
    10.1002/cctc.201000369
  34. Serbanovic, A.; Petrovski, Ž.; Manic, M.; Marques, C.S.; Carrera, G.V.S.M.; Branco, L.C.; Afonso, C.A.M.; da Ponte, M.N.. "Melting behaviour of ionic salts in the presence of high pressure CO2". Fluid Phase Equilibria 294 1-2 (2010): 121-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956877964&partnerID=MN8TOARS.
    10.1016/j.fluid.2010.03.015
  35. de Castro, C.A.N.; Langa, E.; Morais, A.L.; Lopes, M.L.M.; Lourenço, M.J.; Santos, F.J.; Santos, M.S.C.; et al. "Studies on the density, heat capacity, surface tension and infinite dilution diffusion with the ionic liquids [C4mim][NTf2], [C4mim][dca], [C2mim][EtOSO3] and [Aliquat][dca]". Fluid Phase Equilibria 294 1-2 (2010): 157-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956341317&partnerID=MN8TOARS.
    10.1016/j.fluid.2010.03.010
  36. Marques, C.S.; Burke, A.J.. "Catalytic enantioselective addition of phenylboronic acid and phenylboroxine to N-tosylimines: PdII and RhI catalysis". European Journal of Organic Chemistry 9 (2010): 1639-1643. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949281902&partnerID=MN8TOARS.
    10.1002/ejoc.200901139
  37. Marques, C.S.; Ramalho, J.P.P.; Burke, A.J.. "The benzilic ester rearrangement: Synthesis of labelled compounds and theoretical studies". Journal of Physical Organic Chemistry 22 8 (2009): 735-739. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650793343&partnerID=MN8TOARS.
    10.1002/poc.1509
  38. Frade, R.F.M.; Rosatella, A.A.; Marques, C.S.; Branco, L.C.; Kulkarni, P.S.; Mateus, N.M.M.; Afonso, C.A.M.; Duarte, C.M.M.. "Toxicological evaluation on human colon carcinoma cell line (CaCo-2) of ionic liquids based on imidazolium, guanidinium, ammonium, phosphonium, pyridinium and pyrrolidinium cations". Green Chemistry 11 10 (2009): 1660-1665. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350068271&partnerID=MN8TOARS.
    10.1039/b914284n
  39. Marques, C.S.; Burke, A.J.. "Rh(I)-catalyzed asymmetric hydrosilylation and hydroboration/oxidation reactions using berens ligand". Synthetic Communications 38 23 (2008): 4207-4214. http://www.scopus.com/inward/record.url?eid=2-s2.0-55349138429&partnerID=MN8TOARS.
    10.1080/00397910802323106
  40. Martins, J.G.; Barrulas, P.C.; Marques, C.S.; Burke, A.J.. "New route to N-alkylated trans-pyrrolidine diols from 2,2,3,3- tetramethoxybutane-protected dimethyl tartrate". Synthetic Communications 38 9 (2008): 1365-1374. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149109718&partnerID=MN8TOARS.
    10.1080/00397910801916520
  41. Burke, A.J.; Marques, C.S.. "Mechanistic and synthetic aspects of the benzilic acid and ester rearrangements". Mini-Reviews in Organic Chemistry 4 4 (2007): 310-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749048848&partnerID=MN8TOARS.
    10.2174/157019307782411707
  42. Marques, C.S.; Burke, A.J.. "Palladium catalysed enantioselective asymmetric allylic alkylations using the Berens' DIOP analogue". Tetrahedron Asymmetry 18 15 (2007): 1804-1808. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548459374&partnerID=MN8TOARS.
    10.1016/j.tetasy.2007.07.004
  43. Marques, C.S.; Moura, N.M.M.; Burke, A.J.; Furtado, O.R.. "The catalytic tandem oxidation/benzilic ester rearrangement (BER): insights into reaction mechanism and stereoselectivity". Tetrahedron Letters 48 45 (2007): 7957-7960. http://www.scopus.com/inward/record.url?eid=2-s2.0-35048890991&partnerID=MN8TOARS.
    10.1016/j.tetlet.2007.09.066
  44. Marques, C.S.; Moura, N.; Burke, A.J.. "A simple, highly regioselective, one-pot stereoselective synthesis of tertiary a-hydroxyesters: a tandem oxidation/benzilic ester rearrangement". Tetrahedron Letters 47 34 (2006): 6049-6052. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745989231&partnerID=MN8TOARS.
    10.1016/j.tetlet.2006.06.107
Preprint
  1. Marques, Carolina; González-Bakker, Aday; Padrón, José M. "The Ugi4CR as effective tool to access promising anticancer isatin-based a-acetoamide carboxamide oxindole hybrids". 2023. http://dx.doi.org/10.3762/bxiv.2023.60.v1.
    10.3762/bxiv.2023.60.v1
Thesis / Dissertation
  1. Marques, Carolina. "Synthesis and Evaluation of Chiral Phosphine and NHC-Ligands for Heterogeneous Asymmetric Catalysis". PhD, Universidade de Évora, 2013. https://dspace.uevora.pt/rdpc/handle/10174/15896.
  2. Marques, Carolina. "Síntese Estéreo-Selectiva de a-Hidroxiésteres Terciários". Degree, Universidade de Évora, 2005. https://catalogo.bib.uevora.pt/cgi-bin/koha/opac-detail.pl?biblionumber=153883.

Intellectual property

Patent
  1. Marques, Carolina. 2022. "Compostos Derivados de 3-Hidroxioxindole e 3-Alcoxioxindole Terciários como Inibidores de Acetilcolinesterase e Butirilcolinesterase e Processo para a sua Obtenção". Portugal.
  2. Marques, Carolina. 2022. "Pentacyclic Diamides with Optoelectronic Applications, Methods to Produce them and uses thereof".
  3. Marques, Carolina. 2021. "Processo para a Obtenção de Compostos Derivados de 3-Hidroxioxindole e 3-Alcoxioxindole Terciários". Portugal.
  4. Marques, Carolina. 2020. "Novas Diamidas Pentacíclicas com Aplicações Optoelectrónicas, Métodos de Produção e usos dos mesmos". Portugal.
    Granted/Issued
  5. Marques, Carolina. 2018. "Novel N-(1,2,3-Triazolmethyl)Isatin and N-(1,2,3-Triazolmethyl)-3-Hydroxy-3-aryloxindoles with Cytotoxic and Anti-Tumor Activity".
    Granted/Issued
  6. Marques, Carolina. 2018. "N-(1,2,3-Triazolmetil)-3-Hidroxi-3-ariloxindoles quirais não-racémicos". Portugal.
    Granted/Issued
  7. Marques, Carolina. 2017. "Novel Cytotoxic Chiral Non-racemic N-(1,2,3-Triazolmethyl)-3-Hydroxy-3-aryloxindoles". Portugal.
    Granted/Issued
  8. Marques, Carolina. 2016. "Derivados de 3-hidroxioxindole e 3-alcoxioxindole terciários como inibidores de acetilcolinesterase e butirilcolinesterase". Portugal.
    Granted/Issued
  9. Marques, Carolina. 2015. "Process for preparing cyclic chiral amines and alcohols by intramolecular catalytic arylation of boronic acid and ester aldehydes and imine substrates".
    Granted/Issued
  10. Marques, Carolina. 2015. "Processo catalítico para a arilação de ésteres de glioxalato em a-hidroxi-ésteres com metais-carbenos N-heterocíclicos bidentados". Portugal.
    Granted/Issued
  11. Marques, Carolina. 2014. "Novos catalisadores contendo novos carbenos N-heterocíclicos (NHCs) quirais: Arilações catalíticas". Portugal.
    Granted/Issued

Other

Spin-off company
  1. 2009. ChiraTecnics Lda. Manufacture of ligands and reagents (building-blocks).. http://www.chiratecnics.com.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/23 Oxindole-Small-Molecule Hybrids in Complex Diseases 15th National Organic Chemistry Meeting and 8th National Medicinal Chemistry Meeting
University of Algarve (Faro, Portugal)
2022/11/09 Desenvolvimento de Fármacos; Um Caso de Estudo Pós-graduação em Ciclos de Vida do Medicamento e do Dispositivo Médico
University of Évora - Escola de Saúde e Desenvolvimento Humano (Portugal)
2022/04/20 Highway to bioactivity: isatin-based multicomponent reactions 14º National Organic Chemistry Meeting and 7th National Medicinal Chemistry Meeting
(Portugal)
2021/12/15 Seminários de Investigação Bioquímica Invited oral communication
University of Évora, within the course Seminários de Investigação Bioquímica (Portugal)
2021/07/15 Exploring N-1,2,3-Triazole-Isatin-Oxindole Hybrids as Promising Inhibitors Against Two of the Deadliest Diseases Worldwide XXVII Encontro Nacional da Sociedade Portuguesa de Química
Portuguese Chemical Society
2021/07/07 Investigating Privileged Isatin-based Heterocycles Invited oral communication
LAQV-Webinar sessions, Research Group Molecular Synthesis (Portugal)
2020/01/15 Exploring heterocyclic frameworks – small molecules, endless potential 13th National Organic Chemistry Meeting and 6th National Medicinal Chemistry Meeting
Universidade de Aveiro (Aveiro, Portugal)
2019/06/13 Novel Chromane Derivatives for Alzheimer’s Disease 4th Annual meeting - MuTaLig Cost Action
University "Magna Græcia" of Catanzaro (Catanzaro, Italy)
2019/02/23 Isatin-Triazole Hybrids: Lymphoma Anti-Proliferation and BuChE Inbibition 3rd WG meeting – Activities of young investigators within the WG MuTaLig COST Action
Faculté de Farmacie de Paris (Paris, France)
2016/05/26 Modular Oxindole Synthesis - a General an Efficient Rhodium-Catalysed Addition of Arylboronic Acids to Isatin-Derived N-Boc-Protected Ketimines 5th Portuguese Young Chemists Meeting (5th PyChem) and 1st European Young Chemists
Centro Cultural Vila Flor (Guimarães, Portugal)
2014/11/26 Synthesis and Evaluation of Chiral Phosphine and NHC-Ligands for Heterogeneous Asymmetric Catalysis Invited oral communication
University of Évora (Portugal)
2013/09/04 Synthesis and Evaluation of Chiral Phosphine and NHC-Ligands for Heterogeneous Asymmetric Catalysis 10º Encontro Nacional de Química Orgânica e 1º Simpósio Luso-Brasileiro
Faculdade de Farmácia, Universidade de Lisboa (Lisbon, Portugal)
2011/07/03 Catalytic Asymmetric Imine Arylation - An Easy Route to Biologically Active Chiral Amines 12º Encontro Nacional da SPQ
Universidade do Minho (Braga, Portugal)
2010/09/05 Catalytic Enantioselective arylation of activated Imines: A powerful approach to biologically active Amines ESF-COST High-Level Research Conference
Hotel Villa del Mare (Maratea, Italy)
2009/06/15 New and not so new Ionic Liquids – High Scale synthesis and Purification 1º Encontro Ibérico de Líquidos Iónico e 9º Encontro Nacional de Química-Física
Universidade de Aveiro (Aveiro)
2008/10/15 Application of “Borrowed” P,P-Ligands in Catalytic Asymmetric Synthesis 1st Portuguese Young Chemists Meeting (1st PyChem)
Instituto Superior Técnico (Lisbon, Portugal)
2007/07/16 Enantioselectivity Asymmetric Allylic Alkylations using a DIOP Analogue with a 1,4-dioxane backbone 7º Encontro Nacional de Química Orgânica e 1º Simpósio Luso-Françês de Química Orgânica
Fundação Calouste Gulbenkian (Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current Síntese de derivados de benzamidas como potenciais agentes anticancerígenos
Supervisor
 Biochemistry (Degree)
Universidade de Évora Departamento de Química, Portugal
2023 - Current Generation of a small library of indole derivatives to target drug resistance in cancer
Co-supervisor
 Química Medicinal e Biofarmacêutica (Master)
Universidade de Évora, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - 2023 A importância dos anestésicos locais e a síntese de lidocaína e derivados
Supervisor
 Graduation in Chemistry (Degree)
Universidade de Évora, Portugal
2022 - 2022 Benzodiazepinas: estudo da sua importância como fármacos e síntese de uma família de derivados
Supervisor
 Graduation in Biochemistry (Degree)
Universidade de Évora, Portugal
2021 - 2021 Fármacos anti-inflamatórios não esteroides: revisão da literatura e síntese de Diclofenac e derivados
Supervisor
 Graduation in Biochemistry (Degree)
Universidade de Évora, Portugal
2020 - 2020/07 "Pequenas moléculas, grandes feitos: Síntese de um fungicida "
Supervisor
 Graduation in Biochemistry (Degree)
Universidade de Évora, Portugal
2018 - 2018 Síntese catalítica de novos compostos heterocíclicos com potencial actividade biológica
Co-supervisor
 Biochemistry (Degree)
Universidade de Évora, Portugal
2016 - 2016 Descoberta de novos fármacos para a doença de Alzheimer - Tentativa de síntese de aminoisoquinolinonas e estudo de relação actividade estrutura (SAR)
Co-supervisor
 Biochemistry (Degree)
Universidade de Évora, Portugal
2015 - 2016 Estudos de vias sintéticas catalíticas para benzociclo-alcanóis e análogos - potenciais fármacos para a doença de Alzheimer
Co-supervisor
 Chemistry (Master)
Universidade de Évora, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023 - 2023 Member of the organizing committee of the International Symposium on Synthesis and Catalysis - ISySyCat_2023 (2023/09/05 - 2023/09/08)
Symposium (Member of the Organising Committee)
 Universidade de Évora, Portugal
2021/08/31 - 2021/09/03 Member of the organizing committee of the International Symposium on Synthesis and Catalysis - ISySyCat_2021, in Universidade de Évora, Portugal (31 of August to 3 of September of 2021). (2021/08/31 - 2021/09/03)
Symposium (Member of the Organising Committee)
 Universidade de Évora, Portugal
2019/09/03 - 2019/09/06 Member of the organizing committee of the International Symposium on Synthesis and Catalysis - ISySyCat_2019, Universidade de Évora, Portugal, 3rd to 6th of September of 2019 (2019/09/03 - 2019/09/06)
Symposium (Member of the Organising Committee)
 Universidade de Évora, Portugal
2017/09/05 - 2017/09/08 Member of the organizing committee of the International Symposium on Synthesis and Catalysis - ISySyCat_2017, Universidade de Évora, Portugal, 5th to 8th of September of 2017 (2017/09/05 - 2017/09/08)
Symposium (Member of the Organising Committee)
 Universidade de Évora, Portugal
2015/09/02 - 2015/09/04 Member of the organizing committee of the International Symposium on Synthesis and Catalysis - ISySyCat_2015, Universidade de Évora, Portugal, 2nd to 4th of September of 2015 (2015/09/02 - 2015/09/04)
Symposium (Member of the Organising Committee)
 Universidade de Évora, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/02/12 - Current The Global Women’s Breakfast was designed to assist women chemists to expand their network of contacts, both locally and internationally. Women at different stages of their individual careers were encouraged to inform each other about their career progress, and together explore opportunities, in professional development and in research or teaching horizons. Organizations of all types, e.g., universities, companies, national chemistry societies, government laboratories, and other scientific organizations, were invited to participate.
Workshop
 IUPAC100 Global Women’s Breakfast, Empowering Women in Chemistry: A Global Networking Event
Universidade de Évora, Portugal
2023/03 - 2023/05 Training course in Innovation and Industrial Property in Health
Workshop
 Micro Accreditation in Innovation and Industrial Property in Health
Universidade de Évora, Portugal
2008/05/05 - 2008/05/07 Training action: Ressonância Magnética Nuclear: da teoria à prática
Exhibition
 Ressonância Magnética Nuclear: da teoria à prática
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2007/12/13 - 2007/12/13 Ide@ue - inovar, desenvolver e empreender na Universidade de Évora
Seminar
Universidade de Évora, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/07/27 Catalytic Synthesis of Bioactive Nitrogen Heterocycles
(Thesis) Main arguer
 Amina Moutayakine (PhD)
Universidade de Évora, Portugal
2021/09/20 Principal jury on the final year report of Graduation courses
(Thesis) Main arguer
 Filipa Teixeira Pinto (Other)
Universidade de Évora, Portugal
2019/07/25 Principal jury on the final year report of Graduation courses
(Thesis) Main arguer
 Ana Silva (Other)
Universidade de Évora, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024 - 2024 Bioorganic Chemistry Elsevier
2023/04 - 2023/04 Molecules (1420-3049) mdpi
2023 - 2023 International Journal of Molecular Sciences MDPI
2023 - 2023 Applied Sciences MDPI
2023 - 2023 Organics MDPI
2023 - 2023 Chemistry Select Wiley
2022/12 - 2022/12 Molbank (1422-8599) mdpi
2022/10 - 2022/10 Journal of Molecular Structure (1872-8014) Elsevier
2022/10 - 2022/10 Pharmaceuticals (1424-8247) mdpi
2022/09 - 2022/09 Molecules (1420-3049) mdpi
2022/07 - 2022/07 Molecules ( 1420-3049) mdpi
2022/06 - 2022/06 Química (0870-1180) Sociedade Portuguesa de Química
2021/06 - 2021/06 Molecules ( 1420-3049) MDPI
2020/07 - 2020/07 Bioorganic Chemistry (0045-2068) Elsevier
2020/04 - 2020/04 The Journal of Organic Chemistry (0022-3263) ACS publications
2020/03 - 2020/03 European Journal of Medicinal Chemistry (0223-5234) Elsevier

Committee member

Activity description
Role 		Institution / Organization
2021 - Current Alternate candidate, List R, for the Senate of the University of Évora.
Member
 Universidade de Évora, Portugal
2020 - Current Effective candidate List U, for the General Council of the University of Évora
Member
 Universidade de Évora, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023 - 2024 Metabolism and Energetics - Course code QUI0358L Biochemistry (Licenciatura) Universidade de Évora Departamento de Química, Portugal
2023 - 2024 BioOrganic Chemistry - Course code QUI13561L Biochemistry (Licenciatura) Universidade de Évora Departamento de Química, Portugal
2023 - 2024 Biochemistry and Molecular Biotechnology - course code QUI13647M Masters in Biochemistry (Mestrado) Universidade de Évora Departamento de Química, Portugal
2023 - 2024 Catalysis and Catalytic Methods QUI13544M Masters in Chemistry (Mestrado) Universidade de Évora Departamento de Química, Portugal
2022 - 2023 Metabolism and Energetics - Course code QUI0358L Biochemistry and Human Biology (Licenciatura) Universidade de Évora, Portugal
2022 - 2023 BioOrganic Chemistry - Course code QUI13561L Biochemistry (Licenciatura) Universidade de Évora, Portugal
2022 - 2023 Biochemistry and Molecular Biotechnology - course code QUI13647M Masters in Biochemistry (Mestrado) Universidade de Évora, Portugal
2021 - 2022 Metabolism and Energetics - Course code QUI0358L Biochemistry and Human Biology (Licenciatura) Universidade de Évora, Portugal
2021 - 2022 BioOrganic Chemistry - Course code QUI13561L Biochemistry (Licenciatura) Universidade de Évora, Portugal
2021 - 2022 Biochemistry and Molecular Biotechnology - course code QUI13647M Biochemistry (Mestrado) Universidade de Évora, Portugal
2021 - 2022 Structure Determination Mechanisms in Organic Chemistry PhD in Chemistry (Doutoramento) Universidade de Évora, Portugal
2020/10 - 2021/02 Metabolism and Energetics - Course code QUI0358L Biochemistry and Human Biology (Licenciatura) Universidade de Évora, Portugal
2019/09 - 2020/02 Metabolism and Energetics - Course code QUI0358L Biochemistry and Human Biology (Licenciatura) Universidade de Évora, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/04/15 “Carolina Marques faz pesquisa com aplicação na luta contra o cancro”, journal O Alcoa, 15th of April of 2021 O Alcoa
2021/03/17 “Universidade de Évora desenvolve moléculas para tratar vários tipos de cancro”, journal O Público, 17th of March of 2021 O Público
2017/07/03 “Universidade de Évora lidera equipa que cria novas moléculas para tratar Alzheimer”, journal Diário de Notícias, 3rd of July of 2017. Diário de Notícias

Interview (tv / radio show)

Program Topic
2023 - 2023 90 segundos de Ciência, Antena 1 ELPIS Project

Journal scientific committee

Journal title (ISSN) Publisher
2023 - Current Molecules (1420-3049) MDPI

Mentoring / Tutoring

Topic Student name
2024 - Current Research grant holder for the project ConChiMOL (2022.01391.PTDC) Yasmine Fernine
2023/11 - Current Research grant holder for the project ELPIS (2022.02910.PTDC) Ana Margarida Janeiro

Other jury / evaluation

Activity description Institution / Organization
2023 - 2023 Member of the jury, as Alternate Member, for the award of a Master's Research Scholarship, within the scope of the activities of the ConChiMOL project - Structurally Contorted and Chiral Molecules for Optoelectronic Applications (2022.01391.PTDC); notice 895148, University of Coimbra. Universidade de Coimbra, Portugal
2023 - 2023 Member of the jury, as President, for the award of a Research Grant for a Graduate, within the scope of the activities of the ELPIS project: Attractive Oxindole Libraries as Promising Tyrosine Kinase Inhibitors for Targeted Therapy in Cancer (2022.02910.PTDC); University of Évora. Universidade de Évora, Portugal
2023 - 2023 Member of the jury, as an Effective Member, for the award of a Master's Research Scholarship, within the scope of the activities of the ConChiMOL project - Structurally Contorted and Chiral Molecules for Optoelectronic Applications (2022.01391.PTDC); University of Évora. Universidade de Évora, Portugal
Distinctions

Award

2021 Best poster award, “Isatin as a Central “Puzzle Piece” for Multicomponent Reactions (MCRs)”
2013 Best Doctoral Thesis in Organic Chemistry prize
Sociedade Portuguesa de Química, Portugal