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I am a researcher in neuroscience with experience in the immunology field, especially in the context of cerebrovascular diseases. During my PhD and my postdoc experiences, I have acquired important knowledge about ischemia, animal models and behavior in the context of cerebrovascular diseases. My career started on 2005 as a PhD student in Santiago de Compostela, Spain. After completing a short postdoctoral stage at Research Institute Germans Trias I Pujol (Badalona, Spain), I did a postdoctoral period at the prestigious University of Cornell, New York, before joining the Champalimaud Foundation (January 2019), where I got a position from the FCT Stimulus of Scientific Employment to work as a Researcher Assistant. Along all steps of my career, I have been strongly involved in obtaining fellowships and funding to support myself and the research projects in my hosting labs. Apart from obtaining competitive felowships during my PhD (“Xunta de Galicia- Ayudas de tercer ciclo” and “Ayudas predoctorales de Formación en Investigación-Instituto de Salud Carlos III” from the Spanish Ministry of Health) and my postdoctoral steps (“Sara Borrell- Instituto de Salud Carlos III” from the Spanish Ministry of Health), during my whole career I have been involved in grant applications to fund my research projects. As a result, I have participated in 12 competitive national and international projects. Remarkably it must be highlighted my role, during my postdoctoral research in USA, in collaborating to obtain 2 NIH (National Institute of Health of United States of America) grants (R01 NS09450701A1 and R01 NS100447-01). These two grants strongly guarantee the finance support of my hosting laboratory with $370,781 and $707,310 respectively, per year for 5 years (from 2016 to 2021). As a result of my participation in these projects, I have achieved an extensive record of publications (45) and conference communications (45), in addition to one international patent. I have accumulated a total of 45 published papers in peer-reviewed journals, 16 as first author with a total impact factor of more than 200 points. My H-index is 26 (Google Scholar) and my papers have been cited a total of 2640 times. Besides the number of papers, the quality of my publication record has been progressively improving, being, in the last years main author of papers in Nature medicine (first co-author, 2016) and Nature Neuroscience (Second author, 2018).
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Identificação

Identificação pessoal

Nome completo
David Brea Lopez

Nomes de citação

  • Brea, David

Identificadores de autor

Ciência ID
E41C-A3EA-44C9
ORCID iD
0000-0003-2365-7374

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Galego Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador elementar (A1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2010
Concluído
 Molecular biology and Biotechnology (University of Santiago de Compostela, Espanha) (Doutoramento)
Universidade de Santiago de Compostela, Espanha
"Toll-like receptors in cerebral ischemia" (TESE/DISSERTAÇÃO)
 Sobresaliente cum laude (maximun grade in Spain)
2007
Concluído
 Biotecnologia (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Santiago de Compostela, Espanha
"Proteomics of Endothelial Progenitor Cells" (TESE/DISSERTAÇÃO)
 Sobresaliente cum laude (maximun grade in Spain)
2005
Concluído
 Licenciatura en Biologia (Especialidade en Biologia Molecular) (Licenciatura)
Universidade de Santiago de Compostela, Espanha
"NA" (TESE/DISSERTAÇÃO)
 Sobresaliente
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/06/01 - Atual Assistente de Investigação (carreira) (Investigação) Fundação Champalimaud, Portugal
2017/04/20 - 2018/12/19 Assistente de Investigação (carreira) (Investigação) Weill Cornell Medicine Feil Family Brain and Mind Research Institute, Estados Unidos
2014/05/05 - 2017/04/19 Pós-doutorado (Investigação) Weill Cornell Medicine Feil Family Brain and Mind Research Institute, Estados Unidos
2013/07/01 - 2014/05/04 Investigador visitante (Investigação) Weill Cornell Medicine Feil Family Brain and Mind Research Institute, Estados Unidos
2012/01/01 - 2014/04/21 Pós-doutorado (Investigação) Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Espanha
2011/01/01 - 2011/12/31 Pós-doutorado (Investigação) Fundación Ramón Domínguez, Espanha
2005/09/01 - 2010/12/31 Investigador (Investigação) Fundación Ramón Domínguez, Espanha
Projetos

Bolsa

Designação Financiadores
2021/01/01 - 2023/12/31 Regulamento da imunidade intestinal por sinais derivados do cérebro
PTDC/MED-IMU/0870/2020
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2016/01/01 - 2018/12/17 APOE4 AND MECHANISMS OF DIFFUSE WHITE MATTER INJURY
R01 NS100447-0
Investigador
National Institute of Neurological Disorders and Stroke, Estados Unidos
 National Institute of Neurological Disorders and Stroke
Concluído
2016/01/01 - 2018/12/17 Immunomodulation by Commensal Microbiota: Role in Ischemic Brain Injury
R01 NS094507-01A1
Investigador
National Institute of Neurological Disorders and Stroke
2012/01/01 - 2014/12/31 LAS CÉLULAS T REGULADORAS COMO NEXO DE UNIÓN ENTRE NEUROPROTECCIÓN Y NEURORREPARACIÓN TRAS LA ISQUEMIA CEREBRAL
PI11/02636
Investigador
Gobierno de España Ministerio de Ciencia e Innovación
Concluído
2012/01/01 - 2014/12/31 TROYANOS TERANÓSTICOS PARA DIAGNÓSTICO Y TRATAMIENTO EN LA ISQUEMIA CEREBRAL. ESTUDIO PRECLÍNICO IN VIVO.
PI11/02161
Investigador
Gobierno de España Ministerio de Ciencia e Innovación
2010/01/01 - 2013/12/31 UTILIDAD DE LA LACTOFERRINA Y DE LOS RECEPTORES TOLL-LIKE EN EL BLOQUEO DE LA PROGRESIÓN DEL QUERATOCONO
10 PXIB 918 156 PR
Investigador
Xunta de Galicia Consellería de Cultura Educacion e Ordenación Universitaria
2009/01/01 - 2012/12/31 NEURORREPARACIÓN EN LA ISQUEMIA CEREBRAL MEDIADA POR VECTORIZACIÓN MAGNÉTICA DE CÉLULAS MADRE NEURONALES ACTIVADAS.
09CS4057918PR
Investigador
Xunta de Galicia Consellería de Cultura Educacion e Ordenación Universitaria
Concluído
2009/01/01 - 2011/12/31 APLICACION DE FACTORES DE CRECIMIENTO ESTIMULANTES DEL DESARROLLO Y DIFERENCIACION DE CELULAS PROGENITORAS ENDOTELIALES EN LA ISQUEMIA CEREBRAL: ESTUDIO CLINICO - EXPERIMENTAL
SAF2008-00737
Investigador
Gobierno de España Ministerio de Ciencia e Innovación
Concluído
2009/01/01 - 2011/12/31 LIPOSOMAS VECTORIZADOS HACIA LA ZONA PERI-INFARTO COMO NUEVA ESTRATEGIA TERAPÉUTICA EN LA ISQUEMIA CEREBRAL.
PS09/32
Investigador
Xunta de Galicia Consellería de Sanidade
2008/01/01 - 2010/12/31 NEURORREPRACIÓN NA HEMORRAXIA CEREBRAL: APLICABILIDADE NA CLÍNICA DE MARCADORES MOLECULARES E CELULARES DE REXENERACIÓN TISULAR E PLASTICIDADE CEREBRAL
PS07/14
Bolseiro de Doutoramento
Fundación Ramón Domínguez, Espanha
 Xunta de Galicia Consellería de Sanidade
Concluído
2008/01/01 - 2010/12/31 ESTUDIO DE LOS RECEPTORES TOLL LIKE COMO DIANA TERAPÉUTICA EN EL ICTUS ISQUÉMICO.
PS08/23
Bolseiro de Doutoramento
2006/01/01 - 2009/12/31 PROTEÓMICA DE EXPRESIÓN DE LAS CÉLULAS PROGENITORAS ENDOTELIALES EN PACIENTES CON ICTUS ISQUÉMICO Y EN SUJETOS CONTROL
MMA2006
Bolseiro de Doutoramento
Fundación Ramón Domínguez, Espanha
 Fundación Mutua Madrileña
Concluído
2006/01/01 - 2009/12/31 NEURORREPARACIÓN EN LA ISQUEMIA CEREBRAL: APLICABILIDAD EN LA CLÍNICA DE MARCADORES MOLECULARES Y CELULARES DE PLASTICIDAD CEREBRAL.
PGIDIT06BTF91801P
Bolseiro de Doutoramento
Fundación Ramón Domínguez, Espanha
 Xunta de Galicia Consellería de Cultura Educacion e Ordenación Universitaria
Concluído
2006/01/01 - 2009/12/31 AXUDAS PARA A CONSOLIDACIÓN E ESTRUTURACIÓN DE UNIDADES DE INVESTIGACIÓN COMPETITIVAS – ANO 2006
XGA2006
Bolseiro de Doutoramento
Xunta de Galicia Consellería de Cultura Educacion e Ordenación Universitaria
Concluído
2005/09/01 - 2007/12/31 DESACOPLAMIENTO MOLECULAR COMO DIANA TERAPÉUTICA DE LA ISQUEMIA CEREBRAL AGUDA. ESTIMACIÓN DE LA PENUMBRA MEDIANTE LA IDENTIFICACIÓN DE MARCADORES BIOLÓGICOS ESPECÍFICOS DE ISQUEMIA Y DE NECROSIS CEREBRAL: CORRELACIÓN CLÍNICO-PET-MOLECULAR.
MMA2005
Bolseiro de Doutoramento
Fundación Ramón Domínguez, Espanha
 Fundación Mutua Madrileña
Concluído
2006/01/01 - 2006/12/31 ESTUDIO PSICOLÓGICO-MOLECULAR DE LA DEPRESIÓN TRAS EL ICTUS.
XXX
Bolseiro de Doutoramento
Fundación Ramón Domínguez, Espanha
 Fundación Mapfre
Concluído
Produções

Publicações

Artigo em revista
  1. Brea, David; Poon, Carrie; Benakis, Corinne; Lubitz, Gabrielle; Murphy, Michelle; Iadecola, Costantino; Anrather, Josef. "Stroke affects intestinal immune cell trafficking to the central nervous system". Brain, Behavior, and Immunity 96 (2021): 295-302. http://dx.doi.org/10.1016/j.bbi.2021.05.008.
    10.1016/j.bbi.2021.05.008
  2. Benakis, Corinne; Poon, Carrie; Lane, Diane; Brea, David; Sita, Giulia; Moore, Jamie; Murphy, Michelle; et al. "Distinct Commensal Bacterial Signature in the Gut Is Associated With Acute and Long-Term Protection From Ischemic Stroke". Stroke 51 6 (2020): 1844-1854. http://dx.doi.org/10.1161/strokeaha.120.029262.
    10.1161/strokeaha.120.029262
  3. David Brea; Mathias Gelderblom; Carrie Poon; Michelle Murphy; Gabrielle Lubitz; Costantino Iadecola; Josef Anrather. "Ablation of nasal-associated lymphoid tissue does not affect focal ischemic brain injury in mice". PLOS ONE 13 10 (2018): e0205470-e0205470. https://doi.org/10.1371/journal.pone.0205470.
    10.1371/journal.pone.0205470
  4. Garcia-Bonilla, Lidia; Brea, David; Benakis, Corinne; Lane, Diane A.; Murphy, Michelle; Moore, Jamie; Racchumi, Gianfranco; et al. "Endogenous Protection from Ischemic Brain Injury by Preconditioned Monocytes". The Journal of Neuroscience 38 30 (2018): 6722-6736. http://dx.doi.org/10.1523/jneurosci.0324-18.2018.
    10.1523/jneurosci.0324-18.2018
  5. Faraco G; Brea D; Garcia-Bonilla L; Wang G; Racchumi G; Chang H; Buendia I; et al. "Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response.". Nature neuroscience (2018): http://europepmc.org/abstract/med/29335605.
    10.1038/s41593-017-0059-z
  6. Lopez, David. "Microbiota differences between commercial breeders impacts the post-stroke immune response.". Brain, behavior, and immunity (2017): http://europepmc.org/abstract/med/28347867.
    10.1016/j.bbi.2017.03.011
  7. Lopez, David. "Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain.". Journal of neuroinflammation (2016): http://europepmc.org/abstract/med/27814740.
    10.1186/s12974-016-0750-0
  8. Benakis C; Brea D; Caballero S; Faraco G; Moore J; Murphy M; Sita G; et al. "Commensal microbiota affects ischemic stroke outcome by regulating intestinal ¿d T cells.". (2016): http://europepmc.org/abstract/med/27019327.
    10.1038/nm.4068
  9. Brea D; Agulla J; Staes A; Gevaert K; Campos F; Sobrino T; Blanco M; et al. "Study of Protein Expression in Peri-Infarct Tissue after Cerebral Ischemia.". (2015): http://europepmc.org/abstract/med/26153530.
    10.1038/srep12030
  10. Brea D; Agulla J; Rodríguez-Yáñez M; Barral D; Ramos-Cabrer P; Campos F; Almeida A; Dávalos A; Castillo J. "Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia.". (2014): http://europepmc.org/abstract/med/24889329.
    10.1111/jcmm.12304
  11. Agulla J; Brea D; Argibay B; Novo M; Campos F; Sobrino T; Blanco M; Castillo J; Ramos-Cabrer P. "Quick adjustment of imaging tracer payload, for in vivo applications of theranostic nanostructures in the brain.". (2014): http://europepmc.org/abstract/med/24365481.
    10.1016/j.nano.2013.12.004
  12. Rodríguez-Yáñez M; Castellanos M; Sobrino T; Brea D; Ramos-Cabrer P; Pedraza S; Castiñeiras JA; et al. "Interleukin-10 facilitates the selection of patients for systemic thrombolysis.". (2013): http://europepmc.org/abstract/med/23773291.
    10.1186/1471-2377-13-62
  13. Rodríguez-González R; Baluja A; Veiras Del Río S; Rodríguez A; Rodríguez J; Taboada M; Brea D; Álvarez J. "Effects of sevoflurane postconditioning on cell death, inflammation and TLR expression in human endothelial cells exposed to LPS.". (2013): http://europepmc.org/abstract/med/23552565.
    10.1186/1479-5876-11-87
  14. Agulla J; Brea D; Campos F; Sobrino T; Argibay B; Al-Soufi W; Blanco M; Castillo J; Ramos-Cabrer P. "In vivo theranostics at the peri-infarct region in cerebral ischemia.". (2013): http://europepmc.org/abstract/med/24396517.
    10.7150/thno.7088
  15. Sobrino T; Pérez-Mato M; Brea D; Rodríguez-Yáñez M; Blanco M; Castillo J. "Temporal profile of molecular signatures associated with circulating endothelial progenitor cells in human ischemic stroke.". (2012): http://europepmc.org/abstract/med/22513751.
    10.1002/jnr.23068
  16. Rodríguez-Osorio X; Sobrino T; Brea D; Martínez F; Castillo J; Leira R. "Endothelial progenitor cells: a new key for endothelial dysfunction in migraine.". (2012): http://europepmc.org/abstract/med/22815557.
    10.1212/wnl.0b013e31826170ce
  17. Rodríguez-Yáñez M; Brea D; Arias S; Blanco M; Pumar JM; Castillo J; Sobrino T. "Increased expression of Toll-like receptors 2 and 4 is associated with poor outcome in intracerebral hemorrhage.". (2012): http://europepmc.org/abstract/med/22498099.
    10.1016/j.jneuroim.2012.03.019
  18. Cristobo I; Brea D; Blanco M; Vázquez F; Rodríguez-Yáñez M; Vivancos J; Silva Y; et al. "Usefulness of material recovered from distal embolic protection devices after carotid angioplasty for proteomic studies.". (2012): http://europepmc.org/abstract/med/22626270.
    10.1016/j.jvir.2012.02.004
  19. Campos F; Pérez-Mato M; Agulla J; Blanco M; Barral D; Almeida A; Brea D; et al. "Glutamate excitoxicity is the key molecular mechanism which is influenced by body temperature during the acute phase of brain stroke.". (2012): http://europepmc.org/abstract/med/22952923.
    10.1371/journal.pone.0044191
  20. Brea D; Roquer J; Serena J; Segura T; Castillo J; ARTICO STUDY. "Oxidative stress markers are associated to vascular recurrence in non-cardioembolic stroke patients non-treated with statins.". (2012): http://europepmc.org/abstract/med/22862793.
    10.1186/1471-2377-12-65
  21. Brea D; Rodríguez-González R; Sobrino T; Rodríguez-Yañez M; Blanco M; Castillo J. "Proteomic analysis shows differential protein expression in endothelial progenitor cells between healthy subjects and ischemic stroke patients.". (2011): http://europepmc.org/abstract/med/22196759.
    10.1179/1743132811y.0000000038
  22. Rodríguez-Yáñez M; Sobrino T; Arias S; Vázquez-Herrero F; Brea D; Blanco M; Leira R; et al. "Early biomarkers of clinical-diffusion mismatch in acute ischemic stroke.". (2011): http://europepmc.org/abstract/med/21836082.
    10.1161/strokeaha.111.614503
  23. Agulla J; Argibay B; Perez-Mato M; Brea D; Ramos-Cabrer P; Castillo J. "[Comparison of the lesion produced by permanent focal cerebral ischaemia in three animal models using magnetic resonance imaging].". (2011): http://europepmc.org/abstract/med/21796604.
    10.33588/rn.5305.2010625
  24. Sobrino T; Arias S; Pérez-Mato M; Agulla J; Brea D; Rodríguez-Yáñez M; Castillo J. "Cd34+ progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans.". (2011): http://europepmc.org/abstract/med/21488087.
    10.1002/jnr.22627
  25. Sobrino T; Rodríguez-González R; Blanco M; Brea D; Pérez-Mato M; Rodríguez-Yáñez M; Leira R; Castillo J. "CDP-choline treatment increases circulating endothelial progenitor cells in acute ischemic stroke.". (2011): http://europepmc.org/abstract/med/21708065.
    10.1179/016164110x12807570510176
  26. Campos F; Sobrino T; Ramos-Cabrer P; Argibay B; Agulla J; Pérez-Mato M; Rodríguez-González R; Brea D; Castillo J. "Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study.". (2011): http://europepmc.org/abstract/med/21266983.
    10.1038/jcbfm.2011.3
  27. Brea D; Blanco M; Ramos-Cabrer P; Moldes O; Arias S; Pérez-Mato M; Leira R; Sobrino T; Castillo J. "Toll-like receptors 2 and 4 in ischemic stroke: outcome and therapeutic values.". (2011): http://europepmc.org/abstract/med/21206505.
    10.1038/jcbfm.2010.231
  28. Brea D; Sobrino T; Rodríguez-Yáñez M; Ramos-Cabrer P; Agulla J; Rodríguez-González R; Campos F; Blanco M; Castillo J. "Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke.". (2011): http://europepmc.org/abstract/med/21354862.
    10.1016/j.clim.2011.02.001
  29. Rodríguez-González R; Millán M; Sobrino T; Miranda E; Brea D; de la Ossa NP; Blanco M; et al. "The natural tissue plasminogen activator inhibitor neuroserpin and acute ischaemic stroke outcome.". (2011): http://europepmc.org/abstract/med/21174006.
    10.1160/th10-09-0621
  30. Ramos-Cabrer P; Agulla J; Argibay B; Brea D; Campos F; Castillo J. "[Imaging techniques for studying functional recovery following a stroke: I. Methodological aspects].". (2011): http://europepmc.org/abstract/med/21387252.
    10.33588/RN.5206.2010322
  31. Brea D; Blanco M; Sobrino T; Ramos-Cabrer P; Castillo J. "[The levels of expression of toll-like receptors 2 and 4 in neutrophils are associated with the prognosis of ischaemic stroke patients].". (2011): http://europepmc.org/abstract/med/21246489.
    10.33588/RN.5201.2010494
  32. Rodríguez-González R; Sobrino T; Rodríguez-Yáñez M; Millán M; Brea D; Miranda E; Moldes O; et al. "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke.". (2011): http://europepmc.org/abstract/med/21569344.
    10.1186/1479-5876-9-58
  33. Sobrino T; Millán M; Castellanos M; Blanco M; Brea D; Dorado L; Rodríguez-González R; et al. "Association of growth factors with arterial recanalization and clinical outcome in patients with ischemic stroke treated with tPA.". (2010): http://europepmc.org/abstract/med/20456746.
    10.1111/j.1538-7836.2010.03897.x
  34. Cuenca-López MD; Brea D; Galindo MF; Antón-Martínez D; Sanz MJ; Agulla J; Castillo J; Jordán J. "[Inflammatory response during ischaemic processes: adhesion molecules and immunomodulation].". (2010): http://europepmc.org/abstract/med/20568066.
    10.33588/RN.5101.2009667
  35. Ponce J; Brea D; Carrascal M; Guirao V; Degregorio-Rocasolano N; Sobrino T; Castillo J; Dávalos A; Gasull T. "The effect of simvastatin on the proteome of detergent-resistant membrane domains: decreases of specific proteins previously related to cytoskeleton regulation, calcium homeostasis and cell fate.". (2010): http://europepmc.org/abstract/med/20217863.
    10.1002/pmic.200900055
  36. Cuenca-López MD; Brea D; Segura T; Galindo MF; Antón-Martínez D; Agulla J; Castillo J; Jordán J. "[Inflammation as a therapeutic agent in cerebral infarction: cellular inflammatory response and inflammatory mediators].". (2010): http://europepmc.org/abstract/med/20309833.
    10.33588/RN.5006.2009666
  37. Lema I; Brea D; Rodríguez-González R; Díez-Feijoo E; Sobrino T. "Proteomic analysis of the tear film in patients with keratoconus.". (2010): http://europepmc.org/abstract/med/21042560.
  38. Sobrino T; Arias S; Rodríguez-González R; Brea D; Silva Y; de la Ossa NP; Agulla J; et al. "High serum levels of growth factors are associated with good outcome in intracerebral hemorrhage.". (2009): http://europepmc.org/abstract/med/19756022.
    10.1038/jcbfm.2009.182
  39. Brea D; Sobrino T; Blanco M; Fraga M; Agulla J; Rodríguez-Yáñez M; Rodríguez-González R; et al. "Usefulness of haptoglobin and serum amyloid A proteins as biomarkers for atherothrombotic ischemic stroke diagnosis confirmation.". (2009): http://europepmc.org/abstract/med/19171342.
    10.1016/j.atherosclerosis.2008.12.028
  40. Lema I; Sobrino T; Durán JA; Brea D; Díez-Feijoo E. "Subclinical keratoconus and inflammatory molecules from tears.". (2009): http://europepmc.org/abstract/med/19304583.
    10.1136/bjo.2008.144253
  41. Rodríguez-Yáñez M; Sobrino T; Blanco M; de la Ossa NP; Brea D; Rodríguez-González R; Leira R; Dávalos A; Castillo J. "High serum levels of pro-brain natriuretic peptide (pro BNP) identify cardioembolic origin in undetermined stroke.". (2009): http://europepmc.org/abstract/med/19729800.
    10.3233/dma-2009-0630
  42. Brea D; Sobrino T; Blanco M; Cristobo I; Rodríguez-González R; Rodríguez-Yañez M; Moldes O; et al. "Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke.". (2009): http://europepmc.org/abstract/med/19863297.
    10.1515/cclm.2009.337
  43. Brea D; Sobrino T; Ramos-Cabrer P; Castillo J. "Inflammatory and neuroimmunomodulatory changes in acute cerebral ischemia.". (2009): http://europepmc.org/abstract/med/19342833.
    10.1159/000200441
  44. Brea D; Sobrino T; Ramos-Cabrer P; Castillo J. "[Reorganisation of the cerebral vasculature following ischaemia].". (2009): http://europepmc.org/abstract/med/20013717.
    10.33588/rn.4912.2009564
  45. Jiménez I; Agulla J; Pouso M; Sabucedo M; Rodríguez-Yáñez M; Sobrino T; Brea D; et al. "[Cognitive impairment associated to leukoaraiosis: its pathophysiology, clinical manifestations and treatment].". (2008): http://europepmc.org/abstract/med/19012258.
    10.33588/RN.4710.2008386
  46. Jordán J; Segura T; Brea D; Galindo MF; Castillo J. "Inflammation as therapeutic objective in stroke.". (2008): http://europepmc.org/abstract/med/19075732.
    10.2174/138161208786848766
  47. Sobrino T; Hurtado O; Moro MA; Rodríguez-Yáñez M; Castellanos M; Brea D; Moldes O; et al. "The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome.". (2007): http://europepmc.org/abstract/med/17761925.
    10.1161/strokeaha.107.484386
  48. Castellanos M; Sobrino T; Millán M; García M; Arenillas J; Nombela F; Brea D; et al. "Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: a multicenter confirmatory study.". (2007): http://europepmc.org/abstract/med/17478737.
    10.1161/strokeaha.106.481556
  49. Brea D; Cristobo I; Sobrino T; Rodríguez-González R; Mosquera E; Moldes O; Castillo J. "[Application of proteomics to neurological diseases]". (2007): http://europepmc.org/abstract/med/17364255.
Distinções

Prémio

2016 Best Senior Profesional Trajectory in Research Scientist
2013 PhD Extraordinary Award
2012 Postdoctoral Fellowship
2007 PhD Fellowship
2005 PhD Felloshinp