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Eduardo Alexandre Barros e SIlva. Concluiu o(a) Doutoramento em Ciencias de Engenharia em 2008 pelo(a) Universidade do Porto Faculdade de Engenharia. Publicou 39 artigos em revistas especializadas. Possui 1 livro(s).
Identificação

Identificação pessoal

Nome completo
Eduardo Alexandre Barros e SIlva

Nomes de citação

  • SIlva, Eduardo

Identificadores de autor

Ciência ID
DF11-0221-2D93
ORCID iD
0000-0003-3173-7622
Formação
Grau Classificação
2008
Concluído
 Ciencias de Engenharia (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
"Engineering Vascular Networks" (TESE/DISSERTAÇÃO)
 Muito bom
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/06/01 - Atual Professor Associado (Docente Universitário) University of California, Davis, Estados Unidos
2019/08/01 - 2020/05/30 Professor Visitante (Docente Universitário) Universitetet i Oslo, Noruega

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/11/01 - 2018/05/31 Assistant Professor (tenure track) University of California, Davis, Estados Unidos
2009/05/01 - 2011/10/31 Wyss Technology Development Fellow Harvard University, Estados Unidos
2008/04/01 - 2011/06/30 Lecturer and Instructor on Engineering Sciences & Biotechnology Harvard University, Estados Unidos
2007/02/01 - 2010/05/31 Scientific consultant InCytu, Estados Unidos
2008/03/10 - 2009/04/30 Post-Doc fellow Harvard University, Estados Unidos
Produções

Publicações

Artigo em conferência
  1. Evangelista, M.B.; Silva, E.A.; Kim, E.-S.; L. Granja, P.; J. Mooney, D.. "Influence of different human endothelial cell populations on osteoprogenitors differentiation". 2008.
Artigo em revista
  1. Sands, R. Warren; Verbeke, Catia S.; Ouhara, Kazuhisa; Silva, Eduardo A.; Hsiong, Susan; Kawai, Toshihisa; Mooney, David. "Tuning cytokines enriches dendritic cells and regulatory T cells in the periodontium". Journal of Periodontology (2020): http://dx.doi.org/10.1002/jper.19-0411.
    Publicado • 10.1002/jper.19-0411
  2. Kevin T. Campbell; Kajetan Wysoczynski; Dustin J. Hadley; Eduardo A. Silva. "Computational-Based Design of Hydrogels with Predictable Mesh Properties". ACS Biomaterials Science & Engineering (2020): https://doi.org/10.1021/acsbiomaterials.9b01520.
    10.1021/acsbiomaterials.9b01520
  3. Torres, A.L.; Bidarra, S.J.; Vasconcelos, D.P.; Barbosa, J.N.; Silva, E.A.; Nascimento, D.S.; Barrias, C.C.. "Microvascular engineering: Dynamic changes in microgel-entrapped vascular cells correlates with higher vasculogenic/angiogenic potential". Biomaterials 228 (2020): 119554. http://dx.doi.org/10.1016/j.biomaterials.2019.119554.
    Publicado • 10.1016/j.biomaterials.2019.119554
  4. Yamaguchi; Shams; Silva; Stilhano. "PRP and BMAC for Musculoskeletal Conditions via Biomaterial Carriers". International Journal of Molecular Sciences 20 21 (2019): 5328. http://dx.doi.org/10.3390/ijms20215328.
    Publicado • 10.3390/ijms20215328
  5. Dustin J. Hadley; Eduardo A. Silva. "Thaw-Induced Gelation of Alginate Hydrogels for Versatile Delivery of Therapeutics". Annals of Biomedical Engineering 47 8 (2019): 1701-1710. https://doi.org/10.1007/s10439-019-02282-5.
    10.1007/s10439-019-02282-5
  6. Justin L. Madrigal; Shahin Shams; Roberta S. Stilhano; Eduardo A. Silva. "Characterizing the encapsulation and release of lentivectors and adeno-associated vectors from degradable alginate hydrogels". Biomaterials Science (2019): https://doi.org/10.1039/C8BM01218K.
    10.1039/C8BM01218K
  7. Madrigal JL; Sharma SN; Campbell KT; Stilhano RS; Gijsbers R; Silva EA. "Microgels produced using microfluidic on-chip polymer blending for controlled released of VEGF encoding lentivectors.". Acta biomaterialia (2018): http://europepmc.org/abstract/med/29398644.
    10.1016/j.actbio.2018.01.013
  8. SIlva, Eduardo. "Alginate hydrogels of varied molecular weight distribution enable sustained release of sphingosine-1-phosphate and promote angiogenesis.". Journal of biomedical materials research. Part A (2018): http://europepmc.org/abstract/med/28875559.
    10.1002/jbm.a.36217
  9. SIlva, Eduardo. "Guiding morphogenesis in cell-instructive microgels for therapeutic angiogenesis.". Biomaterials (2017): http://europepmc.org/abstract/med/29120817.
    10.1016/j.biomaterials.2017.10.051
  10. Orbay H; Asserson D; Devi K; Williams PA; Dehghani T; Silva EA; Sahar DE. "Abstract P35: Human Adipose-derived Stem Cells as a Potential Source of Endothelial Cells in Clinical Tissue Engineering Applications.". Plastic and Reconstructive Surgery Global Open (2017): http://europepmc.org/abstract/PMC/PMC5418024.
  11. Madrigal, J.L.; Stilhano, R.; Silva, E.A.. "Biomaterial-guided gene delivery for musculoskeletal tissue repair". Tissue Engineering - Part B: Reviews 23 4 (2017): 347-361. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027411316&partnerID=MN8TOARS.
    10.1089/ten.teb.2016.0462
  12. SIlva, Eduardo. "VEGF and IGF Delivered from Alginate Hydrogels Promote Stable Perfusion Recovery in Ischemic Hind Limbs of Aged Mice and Young Rabbits.". Journal of vascular research (2017): http://europepmc.org/abstract/med/28930755.
    10.1159/000479869
  13. SIlva, Eduardo. "Alginate hydrogels allow for bioactive and sustained release of VEGF-C and VEGF-D for lymphangiogenic therapeutic applications.". PloS one (2017): http://europepmc.org/abstract/med/28723974.
    10.1371/journal.pone.0181484
  14. Murphy, K.C.; Stilhano, R.S.; Mitra, D.; Zhou, D.; Batarni, S.; Silva, E.A.; Leach, J.K.. "Hydrogel biophysical properties instruct coculture-mediated osteogenic potential". FASEB Journal 30 1 (2016): 477-486. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974822860&partnerID=MN8TOARS.
    10.1096/fj.15-279984
  15. Stilhano, R.S.; Madrigal, J.L.; Wong, K.; Williams, P.A.; Martin, P.K.M.; Yamaguchi, F.S.M.; Samoto, V.Y.; Han, S.W.; Silva, E.A.. "Injectable alginate hydrogel for enhanced spatiotemporal control of lentivector delivery in murine skeletal muscle". Journal of Controlled Release 237 (2016): 42-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979055370&partnerID=MN8TOARS.
    10.1016/j.jconrel.2016.06.047
  16. Williams, P.A.; Campbell, K.T.; Gharaviram, H.; Madrigal, J.L.; Silva, E.A.. "Alginate-Chitosan Hydrogels Provide a Sustained Gradient of Sphingosine-1-Phosphate for Therapeutic Angiogenesis". Annals of Biomedical Engineering (2016): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-85000605923&partnerID=MN8TOARS.
    10.1007/s10439-016-1768-2
  17. Madrigal, J.L.; Stilhano, R.S.; Siltanen, C.; Tanaka, K.; Rezvani, S.N.; Morgan, R.P.; Revzin, A.; Han, S.W.; Silva, E.A.. "Microfluidic generation of alginate microgels for the controlled delivery of lentivectors". Journal of Materials Chemistry B 4 43 (2016): 6989-6999. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994626857&partnerID=MN8TOARS.
    10.1039/c6tb02150f
  18. Orbay, H.; Devi, K.; Williams, P.A.; Dehghani, T.; Silva, E.A.; Sahar, D.E.. "Comparison of Endothelial Differentiation Capacities of Human and Rat Adipose-Derived Stem Cells". Plastic and Reconstructive Surgery 138 6 (2016): 1231-1241. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999622559&partnerID=MN8TOARS.
    10.1097/PRS.0000000000002791
  19. Williams, P.A.; Stilhano, R.S.; To, V.P.; Tran, L.; Wong, K.; Silva, E.A.. "Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P)". PLoS ONE 10 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928910419&partnerID=MN8TOARS.
    10.1371/journal.pone.0123437
  20. Tellechea, A.; Silva, E.A.; Min, J.; Leal, E.C.; Auster, M.E.; Pradhan-Nabzdyk, L.; Shih, W.; Mooney, D.J.; Veves, A.. "Alginate and DNA gels are suitable delivery systems for diabetic wound healing". International Journal of Lower Extremity Wounds 14 2 (2015): 146-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937551409&partnerID=MN8TOARS.
    10.1177/1534734615580018
  21. Binder, B.Y.K.; Williams, P.A.; Silva, E.A.; Leach, J.K.. "Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering". Tissue Engineering - Part B: Reviews 21 6 (2015): 531-542. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948185624&partnerID=MN8TOARS.
    10.1089/ten.teb.2015.0107
  22. Williams, P.A.; Silva, E.A.. "The Role of Synthetic Extracellular Matrices in Endothelial Progenitor Cell Homing for Treatment of Vascular Disease". Annals of Biomedical Engineering 43 10 (2015): 2301-2313. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941878897&partnerID=MN8TOARS.
    10.1007/s10439-015-1400-x
  23. Silva, E.A.; Eseonu, C.; Mooney, D.J.. "Endothelial cells expressing low levels of CD143 (ACE) exhibit enhanced sprouting and potency in relieving tissue ischemia". Angiogenesis 17 3 (2014): 617-630. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903907228&partnerID=MN8TOARS.
    10.1007/s10456-014-9414-9
  24. Brudno, Y.; Silva, E.A.; Kearney, C.J.; Lewin, S.A.; Miller, A.; Martinick, K.D.; Aizenberg, M.; Mooney, D.J.. "Refilling drug delivery depots through the blood". Proceedings of the National Academy of Sciences of the United States of America 111 35 (2014): 12722-12727. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907227968&partnerID=MN8TOARS.
    10.1073/pnas.1413027111
  25. Fonseca, K.B.; Gomes, D.B.; Lee, K.; Santos, S.G.; Sousa, A.; Silva, E.A.; Mooney, D.J.; Granja, P.L.; Barrias, C.C.. "Injectable MMP-sensitive alginate hydrogels as hMSC delivery systems". Biomacromolecules 15 1 (2014): 380-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892606344&partnerID=MN8TOARS.
    10.1021/bm4016495
  26. Shamis, Y.; Silva, E.A.; Hewitt, K.J.; Brudno, Y.; Levenberg, S.; Mooney, D.J.; Garlick, J.A.. "Fibroblasts derived from human pluripotent stem cells activate angiogenic responses in vitro and in vivo". PLoS ONE 8 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84893598852&partnerID=MN8TOARS.
    10.1371/journal.pone.0083755
  27. Lui, K.O.; Zangi, L.; Silva, E.A.; Bu, L.; Sahara, M.; Li, R.A.; Mooney, D.J.; Chien, K.R.. "Driving vascular endothelial cell fate of human multipotent Isl1 + heart progenitors with VEGF modified mRNA". Cell Research 23 10 (2013): 1172-1186. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885172335&partnerID=MN8TOARS.
    10.1038/cr.2013.112
  28. Kaigler, D.; Silva, E.A.; Mooney, D.J.. "Guided bone regeneration using injectable vascular endothelial growth factor delivery gel". Journal of Periodontology 84 2 (2013): 230-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873549333&partnerID=MN8TOARS.
    10.1902/jop.2012.110684
  29. Kodiyan, A.; Silva, E.A.; Kim, J.; Aizenberg, M.; Mooney, D.J.. "Surface modification with alginate-derived polymers for stable, protein-repellent, long-circulating gold nanoparticles". ACS Nano 6 6 (2012): 4796-4805. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862852653&partnerID=MN8TOARS.
    10.1021/nn205073n
  30. Vacharathit, V.; Silva, E.A.; Mooney, D.J.. "Viability and functionality of cells delivered from peptide conjugated scaffolds". Biomaterials 32 15 (2011): 3721-3728. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952764288&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2010.12.048
  31. Kim, J.; Cao, L.; Shvartsman, D.; Silva, E.A.; Mooney, D.J.. "Targeted delivery of nanoparticles to ischemic muscle for imaging and therapeutic angiogenesis". Nano Letters 11 2 (2011): 694-700. http://www.scopus.com/inward/record.url?eid=2-s2.0-79851473442&partnerID=MN8TOARS.
    10.1021/nl103812a
  32. Lee, K.; Silva, E.A.; Mooney, D.J.. "Growth factor delivery-based tissue engineering: General approaches and a review of recent developments". Journal of the Royal Society Interface 8 55 (2011): 153-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650842405&partnerID=MN8TOARS.
    10.1098/rsif.2010.0223
  33. Emerich, D.F.; Silva, E.; Ali, O.; Mooney, D.; Bell, W.; Yu, S.J.; Kaneko, Y.; Borlongan, C.. "Injectable VEGF hydrogels produce near complete neurological and anatomical protection following cerebral ischemia in rats". Cell Transplantation 19 9 (2010): 1063-1071. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649866457&partnerID=MN8TOARS.
    10.3727/096368910X498278
  34. Yuen, W.W.; Du, N.R.; Chan, C.H.; Silva, E.A.; Mooney, D.J.. "Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones". Proceedings of the National Academy of Sciences of the United States of America 107 42 (2010): 17933-17938. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149259034&partnerID=MN8TOARS.
    10.1073/pnas.1001192107
  35. Sun, Q.; Silva, E.A.; Wang, A.; Fritton, J.C.; Mooney, D.J.; Schaffler, M.B.; Grossman, P.M.; Rajagopalan, S.. "Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis". Pharmaceutical Research 27 2 (2010): 264-271. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949270271&partnerID=MN8TOARS.
    10.1007/s11095-009-0014-0
  36. Silva, E.A.; Mooney, D.J.. "Effects of VEGF temporal and spatial presentation on angiogenesis". Biomaterials 31 6 (2010): 1235-1241. http://www.scopus.com/inward/record.url?eid=2-s2.0-72149100455&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2009.10.052
  37. Silva, E.A.; Kim, E.-S.; Hyun, J.K.; Mooney, D.J.. "Material-based deployment enhances efficacy of endothelial progenitor cells". Proceedings of the National Academy of Sciences of the United States of America 105 38 (2008): 14347-14352. http://www.scopus.com/inward/record.url?eid=2-s2.0-55749108538&partnerID=MN8TOARS.
    10.1073/pnas.0803873105
  38. Hao, X.; Silva, E.A.; Månsson-Broberg, A.; Grinnemo, K.-H.; Siddiqui, A.J.; Dellgren, G.; Wärdell, E.; et al. "Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction". Cardiovascular Research 75 1 (2007): 178-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249933136&partnerID=MN8TOARS.
    10.1016/j.cardiores.2007.03.028
  39. Mooney, D.J.; Silva, E.A.. "Tissue Engineering: A glue for biomaterials". Nature Materials 6 5 (2007): 327-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247850783&partnerID=MN8TOARS.
    10.1038/nmat1896
  40. Silva, E.A.; Mooney, D.J.. "Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis". Journal of Thrombosis and Haemostasis 5 3 (2007): 590-598. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247610438&partnerID=MN8TOARS.
    10.1111/j.1538-7836.2007.02386.x
  41. Chen, R.R.; Silva, E.A.; Yuen, W.W.; Mooney, D.J.. "Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation". Pharmaceutical Research 24 2 (2007): 258-264. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846050010&partnerID=MN8TOARS.
    10.1007/s11095-006-9173-4
  42. Chen, R.R.; Silva, E.A.; Yuen, W.W.; Brock, A.A.; Fischbach, C.; Lin, A.S.; Guldberg, R.E.; Mooney, D.J.. "Integrated approach to designing growth factor delivery systems". FASEB Journal 21 14 (2007): 3896-3903. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849053301&partnerID=MN8TOARS.
    10.1096/fj.06-7873com
Capítulo de livro
  1. Shams, Shahin; Silva, Eduardo A.. "Bioengineering strategies for gene delivery". In Engineering Strategies for Regenerative Medicine, 107-148. Elsevier, 2020.
    Publicado • 10.1016/b978-0-12-816221-7.00004-5
Livro
  1. Silva, E.A.; Mooney, D.J.. Synthetic Extracellular Matrices for Tissue Engineering and Regeneration. 2004.
    10.1016/S0070-2153(04)64008-7

Outros

Outra produção
  1. Open-source 3D printed air-jet for generating monodispersed alginate microhydrogels. 2019. Dustin J. Hadley; Kevin T. Campbell; Marina H. Gabriel; Eduardo A. Silva. https://doi.org/10.1101/804849.
    10.1101/804849