???global.info.a_carregar???
I am a W3 Full Professor at the University Hospital in Tübingen, where I lead the Advanced Metabolic Imaging and Cell Engineering (AMICI) team. I have supervised, trained, and mentored several high school, undergraduate, and graduate students. To date, my scientific work has resulted in 48 publications in international journals and several prestigious awards. My research group focuses on understanding the physicochemical, biochemical, and biological properties of the next generation of non-invasive metabolic sensors for applications in translational biomedical and clinical sciences. We aim to translate new technologies for in vivo use and validate imaging biomarkers relevant to severe metabolic diseases such as cancer senescence, diabetes, neurodegeneration, cirrhosis, inflammation, and kidney failure. Our laboratory's multidisciplinary research combines advanced multimodal, multiparametric, and state-of-the-art hybrid imaging techniques, enabling accurate disease detection and the prediction of responses to personalized therapies. Our research topics include: 1. Multimodal/Hybrid Imaging of the microenvironment and immunotherapy 2. Hyperpolarized metabolism and (metal)omics 3. Functional quantitative imaging (next generation of imaging agents) 4. Metabolic profiling and aggressiveness
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Andre Ferreira Martins

Nomes de citação

  • Martins, Andre F.
  • Andre F. Martins
  • AF Martins

Identificadores de autor

Ciência ID
931F-8493-9C96
ORCID iD
0000-0002-0171-0261

Endereços de correio eletrónico

  • andre.martins@med.uni-tuebingen.de (Profissional)

Websites

  • http://www.isct.uni-tuebingen.de/wsic/group/staff/staff-member/andre-martins/ (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica - Radiologia, Medicina Nuclear e Imagens Médicas
  • Ciências Exatas - Química - Química Inorgânica
  • Ciências Médicas e da Saúde - Medicina Clínica - Radiologia, Medicina Nuclear e Imagens Médicas
  • Ciências Médicas e da Saúde - Medicina Clínica - Oncologia
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Francês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B2)
Alemão Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2009 - 2013/11/11
Concluído
 Bioquimica / Quimica (Doutoramento)
Universidade de Coimbra, Portugal
"Targeted Multimodal Imaging Agents for the Detection of Aß Plaques in Alzheimer’s Disease" (TESE/DISSERTAÇÃO)
2009/05/01 - 2013/11/10
Concluído
 Chimie du Vivant (Doctorat)
CNRS à Orléans, França
 Summa Cum Laude
2009 - 2009
Concluído
 Quimica (Mestrado)
Centre National de la Recherche Scientifique, França
"Gadolinium based contrast agents" (TESE/DISSERTAÇÃO)
 16.2
2003 - 2008
Concluído
 Bioquimica (Licenciatura)
Universidade de Coimbra, Portugal
"Gadolinium based contrast agents" (TESE/DISSERTAÇÃO)
 16.2
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/02/04 - Atual Investigador principal (carreira) (Investigação) Eberhard Karls Universität Tübingen, Alemanha
Werner Siemens Imaging Center, Alemanha
(...)

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/11/23 - 2019/01/01 Instructor The University of Texas Southwestern Medical Center, Estados Unidos
The University of Texas Southwestern Medical Center, Estados Unidos

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2025/01/20 - Atual Editor Springer Nature New York, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2024/08/01 - Atual Mapping Tumor Metabolic Aggressiveness with hybrid PET/MR Shift Reagents In Vivo
516238665
Investigador responsável
Deutsche Forschungsgemeinschaft, Alemanha
 Deutsche Forschungsgemeinschaft
Em curso
2023/10/01 - Atual Free radical hyperpolarizing agents for ultra-low field Overhauser MR
527345502
Investigador responsável
Deutsche Forschungsgemeinschaft, Alemanha
 Deutsche Forschungsgemeinschaft
Em curso
2021/01/01 - Atual Towards Metabolic Profiling of Tumors in vivo
Fortune
Investigador responsável
Eberhard Karls Universität Tübingen, Alemanha
Em curso
2020/11/01 - Atual Image-guided modulation of tumor aggressiveness
Sofja Kovalevskaja Award
Investigador responsável
Alexander von Humboldt-Stiftung, Alemanha
Em curso
2020/06/01 - Atual PET/MR Imaging of Macrophage Responses to Radiation and Immunotherapy
n/a
Investigador responsável
Stanford University Department of Radiology
Em curso
2018/09/01 - 2023/08/30 Imaging glucose-stimulated zinc secretion (GSZS) from the prostate by MRI: A potentially powerful method for early detection of prostate cancer
RP180178
Outra
Cancer Prevention and Research Institute of Texas, Estados Unidos
 Cancer Prevention and Research Institute of Texas
Em curso
2012/09/19 - 2023/08 Imaging beta cell function in vivo with a Zinc responsive MRI contrast agent
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES/4R01DK095416-05/US
National Institute of Diabetes and Digestive and Kidney Diseases, Estados Unidos
 National Institutes of Health
Em curso
2020/02/01 - 2023/01/31 Towards Metabolic Profiling of Tumours in vivo
NWG_UKT_AnFM
Investigador responsável
Eberhard Karls Universität Tübingen, Alemanha
 Eberhard Karls Universität Tübingen
Em curso

Projeto

Designação Financiadores
2013/01/01 - 2015/12/31 Do espaço químico à função biológica: uma viagem pela mão da UC-NMR
RECI/QEQ-QFI/0168/2012
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Remy Chiaffarelli; Pedro F. Cruz; Jonathan Cotton; Tjark Kelm; Slade Lee; Mohammad Ghaderian; Max Zimmermann; et al. "Metabolic PCTA-Based Shift Reagents for the Detection of Extracellular Lactate Using CEST MRI". JACS Au (2025): https://doi.org/10.1021/jacsau.4c01020.
    10.1021/jacsau.4c01020
  2. Archibald, S.J.; Holland, J.P.; Korde, A.; Martins, A.F.; Shuhendler, A.J.; Scott, P.J.H.. "Combining Nuclear Medicine With Other Modalities: Future Prospect for Multimodality Imaging". Molecular Imaging 23 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85192080450&partnerID=MN8TOARS.
    10.1177/15353508241245265
  3. Kretschmer, Jan; Chiaffarelli, Remy; Vuozzo, Marta; Cotton, Jonathan; Blahut, Jan; Ralis, Jan; Dracinsky, Martin; et al. "A Macrocyclic Hybrid PET/MRI Probe for Quantitative Perfusion Imaging In Vivo". Angewandte Chemie International Edition (2024): https://publons.com/wos-op/publon/69319126/.
    10.1002/ANIE.202409520
  4. Meng, J.-H.; Huang, Y.-B.; Long, J.; Cai, Q.-C.; Qiao, X.; Zhang, Q.-L.; Zhang, L.-D.; et al. "Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS". iScience 27 4 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85189562543&partnerID=MN8TOARS.
    10.1016/j.isci.2024.109469
  5. Paranawithana, N.N.; Chiaffarelli, R.; Kretschmer, J.; Buchanan, E.; Lopez, K.; Zhao, P.; Kiefer, G.; et al. "Enhancing r1 Relaxivity in GdDOTA-Monoamide Complexes through Polar Group-Mediated Ordering of Second-Sphere Water Molecules". Inorganic Chemistry 63 9 (2024): 4072-4077. http://www.scopus.com/inward/record.url?eid=2-s2.0-85186247533&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.3c03639
  6. Knopf, P.; Stowbur, D.; Hoffmann, S.H.L.; Hermann, N.; Maurer, A.; Bucher, V.; Poxleitner, M.; et al. "Acidosis-mediated increase in IFN-¿-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors". Molecular Cancer 22 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85179703345&partnerID=MN8TOARS.
    10.1186/s12943-023-01900-0
  7. Andre Martins; E. Dao; M.V. Clavijo Jordan; K. Geraki; A.F. Martins; S. Chirayil; A.D. Sherry; M.J. Farquharson. "Using micro-synchrotron radiation x-ray fluorescence (µ-SRXRF) for trace metal imaging in the development of MRI contrast agents for prostate cancer imaging". Journal of Trace Elements in Medicine and Biology 74 (2022): 127054-127054. http://dx.doi.org/10.1016/j.jtemb.2022.127054.
    10.1016/j.jtemb.2022.127054
  8. Korde, A.; Mikolajczak, R.; Kolenc, P.; Bouziotis, P.; Westin, H.; Lauritzen, M.; Koole, M.; et al. "Practical considerations for navigating the regulatory landscape of non-clinical studies for clinical translation of radiopharmaceuticals". EJNMMI Radiopharmacy and Chemistry 7 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85134421157&partnerID=MN8TOARS.
    10.1186/s41181-022-00168-x
  9. Zhang, Y.; Zhao, K.; He, H.; Wan, S.; Martins, A.F.; Zhang, L.; Liu, K.. "AT2exMRI Dy-based contrast agent for direct pH imaging using a ratiometric approach". Dalton Transactions 50 6 (2021): 2014-2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100880883&partnerID=MN8TOARS.
    10.1039/d0dt03734f
  10. Anbu, S.; Hoffmann, S.H.L.; Carniato, F.; Kenning, L.; Price, T.W.; Prior, T.J.; Botta, M.; Martins, A.F.; Stasiuk, G.J.. "A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent". Angewandte Chemie - International Edition 60 19 (2021): 10736-10744. http://www.scopus.com/inward/record.url?eid=2-s2.0-85103980307&partnerID=MN8TOARS.
    10.1002/anie.202100885
  11. Ozbakir, H.F.; Miller, A.D.C.; Fishman, K.B.; Martins, A.F.; Kippin, T.E.; Mukherjee, A.. "A Protein-Based Biosensor for Detecting Calcium by Magnetic Resonance Imaging". ACS Sensors 6 9 (2021): 3163-3169. http://www.scopus.com/inward/record.url?eid=2-s2.0-85114471642&partnerID=MN8TOARS.
    10.1021/acssensors.1c01085
  12. Chirayil, S.; Jordan, V.C.; Martins, A.F.; Paranawithana, N.; Ratnakar, S.J.; Sherry, A.D.. "Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI". Inorganic Chemistry 60 4 (2021): 2168-2177. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100803892&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.0c02688
  13. Veronica Clavijo Jordan; Alia Al-Ebraheem; Kalotina Geraki; Erica Dao; Andre F. Martins; Sara Chirayil; Michael Farquharson; A. Dean Sherry. "Synchrotron Radiation X-ray Fluorescence Elemental Mapping in Healthy versus Malignant Prostate Tissues Provides New Insights into the Glucose-Stimulated Zinc Trafficking in the Prostate As Discovered by MRI". Inorganic Chemistry (2019): https://doi.org/10.1021/acs.inorgchem.9b01132.
    10.1021/acs.inorgchem.9b01132
  14. Namini N. Paranawithana; Andre F. Martins; Veronica Clavijo Jordan; Piyu Zhao; Sara Chirayil; Gabriele Meloni; A. Dean Sherry. "A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo". Journal of the American Chemical Society (2019): https://doi.org/10.1021/jacs.8b13493.
    10.1021/jacs.8b13493
  15. Daniel Parrott; W. Shirangi Fernando; Andre Martins. "Smart MRI Agents for Detecting Extracellular Events In Vivo: Progress and Challenges". Inorganics (2019): http://www.mdpi.com/2304-6740/7/2/18.
    10.3390/inorganics7020018
  16. André F. Martins; Veronica Clavijo Jordan; Filip Bochner; Sara Chirayil; Namini Paranawithana; Shanrong Zhang; Su-Tang Lo; et al. "Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn2+ Ions". Journal of the American Chemical Society (2018): https://doi.org/10.1021/jacs.8b07607.
    10.1021/jacs.8b07607
  17. Martins, Andre. "Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor". Molecular Pharmaceutics (2018): http://dx.doi.org/10.1021/acs.molpharmaceut.8b00262.
    10.1021/acs.molpharmaceut.8b00262
  18. Lei Zhang; André F. Martins; Piyu Zhao; Yunkou Wu; Gyula Tircsó; A. Dean Sherry; Martins, Andre. "Lanthanide-Based T2ex and CEST Complexes Provide Insights into the Design of pH Sensitive MRI Agents". Angewandte Chemie 129 52 (2017): 16853-16857. https://doi.org/10.1002/ange.201707959.
    10.1002/ange.201707959
  19. Lei Zhang; Osasere M. Evbuomwan; Michael Tieu; Piyu Zhao; Andre F. Martins; A. Dean Sherry. "Protonation of carboxyl groups in EuDOTA-tetraamide complexes results in catalytic prototropic exchange and quenching of the CEST signal". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 375 2107 (2017): 20170113-20170113. https://doi.org/10.1098/rsta.2017.0113.
    10.1098/rsta.2017.0113
  20. Martins, Andre. "Transition Metal Doping Reveals Link Between Electron T1 Reduction and 13C Dynamic Nuclear Polarization Efficiency.". The journal of physical chemistry. A (2017): http://europepmc.org/abstract/med/29125294.
    10.1021/acs.jpca.7b09448
  21. Martins, Andre. "Enantiomeric recognition of D- and L-lactate by CEST with the aid of a paramagnetic shift reagent.". Journal of the American Chemical Society (2017): http://europepmc.org/abstract/med/29083166.
    10.1021/jacs.7b08292
  22. Martins, Andre. "Zinc as an Imaging Biomarker of Prostate Cancer". Israel Journal of Chemistry (2017): http://dx.doi.org/10.1002/ijch.201700043.
    10.1002/ijch.201700043
  23. Zohreh Hashami; Andre F. Martins; Alexander M. Funk; Veronica Clavijo Jordan; Stéphane Petoud; Svetlana V. Eliseeva; Zoltan Kovacs; Martins, Andre. "Lanthanide DO3A-Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium". European Journal of Inorganic Chemistry 2017 43 (2017): 4965-4968. https://doi.org/10.1002%2Fejic.201701003.
    10.1002/ejic.201701003
  24. Lei Zhang; André F. Martins; Yuyan Mai; Piyu Zhao; Alexander M. Funk; M. Veronica Clavijo Jordan; Shanrong Zhang; et al. "Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent". Chemistry - A European Journal (2017): https://doi.org/10.1002%2Fchem.201604558.
    10.1002/chem.201604558
  25. Niedbalski, P.; Parish, C.; Kiswandhi, A.; Fidelino, L.; Khemtong, C.; Hayati, Z.; Song, L.; et al. "Influence of Dy3+ and Tb3+ doping on 13C dynamic nuclear polarization". Journal of Chemical Physics 146 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85008690486&partnerID=MN8TOARS.
    10.1063/1.4973317
  26. Cemile Kumas; W. Shirangi Fernando; Piyu Zhao; Martín Regueiro-Figueroa; Garry E. Kiefer; André F. Martins; Carlos Platas-Iglesias; A. Dean Sherry. "Unexpected Changes in the Population of Coordination Isomers for the Lanthanide Ion Complexes of DOTMA–Tetraglycinate". Inorg. Chem. (2016): http://dx.doi.org/10.1021/acs.inorgchem.6b01390.
    10.1021/acs.inorgchem.6b01390
  27. W. Shirangi Fernando; André F. Martins; Piyu Zhao; Yunkou Wu; Garry E. Kiefer; Carlos Platas-Iglesias; A. Dean Sherry. "Breaking the Barrier to Slow Water Exchange Rates for Optimal Magnetic Resonance Detection of paraCEST Agents". Inorg. Chem. (2016): http://dx.doi.org/10.1021/acs.inorgchem.5b02850.
    10.1021/acs.inorgchem.5b02850
  28. Andhika Kiswandhi; Peter Niedbalski; Christopher Parish; Pavanjeet Kaur; André Martins; Leila Fidelino; Chalermchai Khemtong; et al. "Impact of Ho3+-doping on13C dynamic nuclear polarization using trityl OX063 free radical". Phys. Chem. Chem. Phys. 18 31 (2016): 21351-21359. http://dx.doi.org/10.1039/c6cp03954e.
    10.1039/c6cp03954e
  29. Damien Cressier; Martine Dhilly; Thang T. Cao Pham; Fabien Fillesoye; Fabienne Gourand; Auriane Maïza; André F. Martins; et al. "Gallium-68 Complexes Conjugated to Pittsburgh Compound B: Radiolabeling and Biological Evaluation". Mol Imaging Biol (2015): http://dx.doi.org/10.1007/s11307-015-0906-9.
    10.1007/s11307-015-0906-9
  30. André F. Martins; Alexandre C. Oliveira; Jean-François Morfin; Douglas V. Laurents; Éva Tóth; Carlos F. G. C. Geraldes. "Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aß amyloid aggregates". J Biol Inorg Chem (2015): http://dx.doi.org/10.1007/s00775-015-1316-9.
    10.1007/s00775-015-1316-9
  31. Yu J; Martins AF; Preihs C; Clavijo Jordan V; Chirayil S; Zhao P; Wu Y; et al. "Amplifying the Sensitivity of Zinc(II) Responsive MRI Contrast Agents by Altering Water Exchange Rates.". (2015): http://europepmc.org/abstract/med/26462412.
  32. Luis M. De León-Rodríguez; André F. Martins; Marco C. Pinho; Neil M. Rofsky; A. Dean Sherry. "Basic MR relaxation mechanisms and contrast agent design". J. Magn. Reson. Imaging 42 3 (2015): 545-565. http://dx.doi.org/10.1002/jmri.24787.
    10.1002/jmri.24787
  33. André F. Martins; David M. Dias; Jean-François Morfin; Sara Lacerda; Douglas V. Laurents; Éva Tóth; Carlos F. G. C. Geraldes. "Interaction of PiB-Derivative Metal Complexes with Beta-Amyloid Peptides: Selective Recognition of the Aggregated Forms". Chem. Eur. J. 21 14 (2015): 5413-5422. http://dx.doi.org/10.1002/chem.201406152.
    10.1002/chem.201406152
  34. Yu, J.; Martins, A.F.; Preihs, C.; Clavijo Jordan, V.; Chirayil, S.; Zhao, P.; Wu, Y.; et al. "Amplifying the Sensitivity of Zinc(II) Responsive MRI Contrast Agents by Altering Water Exchange Rates". Journal of the American Chemical Society 137 44 (2015): 14173-14179. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947460644&partnerID=MN8TOARS.
    10.1021/jacs.5b09158
  35. Martins, André F.; Eliseeva, Svetlana V.; Carvalho, Henrique F.; Teixeira, João M. C.; Paula, Carlos T. B.; Hermann, Petr; Platas-Iglesias, Carlos; et al. "A Bis(pyridine N-oxide) Analogue of DOTA: Relaxometric Properties of the GdIII Complex and Efficient Sensitization of Visible and NIR-Emitting Lanthanide(III) Cations Including PrIII and HoIII". Chemistry – A European Journal (2014): n/a-n/a.
    10.1002/chem.201403856
  36. Monteiro, João P.; Martins, André F.; Nunes, Cláudia; Morais, Catarina M.; Lúcio, Marlene; Reis, Salette; Pinheiro, Teresa J.T.; et al. "A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 8 (2013): 1899-1908.
    Publicado • 10.1016/j.bbamem.2013.04.006
  37. Martins, André F.; Prata, M. I. M.; Rodrigues, S. P. J.; Geraldes, Carlos F. G. C.; Riss, P. J.; Amor-Coarasa, A.; Burchardt, C.; Kroll, C.; Roesch, F.. "Spectroscopic, radiochemical, and theoretical studies of the Ga 3+ - N -2-hydroxyethyl piperazine- N '-2-ethanesulfonic acid (HEPES buffer) system: evidence for the formation of Ga 3+ - HEPES complexes in 68 ¿Ga labeling reactions". Contrast Media & Molecular Imaging 8 3 (2013): 265-273.
    Publicado • 10.1002/cmmi.1517
  38. Martins, André F.; Morfin, Jean-François; Kubicekova, Anna; kubicek; Buron, Frédéric; Suzenet, Franck; Salerno, Milena; et al. "PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of ß-Amyloid Plaques". ACS Medicinal Chemistry Letters 4 5 (2013): 436-440.
    Publicado • 10.1021/ml400042w
  39. Mendonça, Ana C.; Martins, André F.; Melchior, Andrea; Marques, Sérgio M.; Chaves, Sílvia; Villette, Sandrine; Petoud, Stéphane; et al. "New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties". Dalton Transactions 42 17 (2013): 6046-6046.
    Publicado • 10.1039/C2DT32237D
  40. Martins, Andre Ferreira; Ferreira, Miguel F.; Martins, Catarina; Martins, José A.; Tóth, Éva; Rodrigues, Tiago; Geraldes, Carlos F.G.C.; Cerdan, Sebastian; Lopez-Larrubia, Pilar. "Amide conjugates of the DO3A-N-(a-amino)propionate ligand: leads for stable, high relaxivity contrast agents for MRI?". Contrast Media & Molecular Imaging 8 1 (2013): 40-49.
    Publicado
  41. Martins, André F.; Morfin, Jean-François; Geraldes, Carlos F. G. C.; Tóth, Éva. "Gd3+ complexes conjugated to Pittsburgh compound B: potential MRI markers of ß-amyloid plaques". JBIC Journal of Biological Inorganic Chemistry (2013):
    10.1007/s00775-013-1055-8
  42. Ferreira, M. F.; Pereira, G.; Martins, A. F.; Martins, C. I. O.; Prata, M. I. M.; Petoud, S.; Toth, E.; et al. "Ln[DO3A-N-a-(pyrenebutanamido)propionate] complexes: optimized relaxivity and NIR optical properties". Dalton Transactions (2013):
    10.1039/c3dt52958d
  43. Ferreira, M.F.; Martins, A.F.; Martins, C.I.O.; Ferreira, P.M.; Tóth, E.; Rodrigues, T.B.; Calle, D.; et al. "Amide conjugates of the DO3A-N-(a-amino)propionate ligand: Leads for stable, high relaxivity contrast agents for MRI?". Contrast Media and Molecular Imaging 8 1 (2013): 40-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868094442&partnerID=MN8TOARS.
    10.1002/cmmi.1492
  44. Lima, Luís M. P.; Delgado, Rita; Hermann, Petr; Šev¿?ík, Radek; Lubal, Premysl; Carvalho, Henrique F.; Martins, André F.; Tóth, Éva; Geraldes, Carlos F. G. C.. "Tris(phosphonomethyl)cyclen Derivatives: Thermodynamic Stability, Kinetics, Solution Structure, and Relaxivity of Ln3+ Complexes". European Journal of Inorganic Chemistry 2012 15 (2012): 2548-2559.
    Publicado • 10.1002/ejic.201101335
  45. Monteiro, João P.; Martins, André F.; Lúcio, Marlene; Reis, Salette; Geraldes, Carlos F. G. C.; Oliveira, Paulo J.; Jurado, Amália S.. "Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling". Journal of Bioenergetics and Biomembranes 43 3 (2011): 287-298.
    Publicado • 10.1007/s10863-011-9359-2
  46. Monteiro, João P.; Martins, André F.; Lúcio, Marlene; Reis, Salette; Pinheiro, Teresa J.T.; Geraldes, Carlos F.G.C.; Oliveira, Paulo J.; Jurado, Amália S.. "Nimesulide interaction with membrane model systems: Are membrane physical effects involved in nimesulide mitochondrial toxicity?". Toxicology in Vitro 25 6 (2011): 1215-1223.
    Publicado • 10.1016/j.tiv.2011.05.014
  47. Chaves, Sílvia; Mendonça, Ana C.; Marques, Sérgio M.; Prata, M. Isabel; Santos, Ana C.; Martins, André F.; Geraldes, Carlos F.G.C.; Santos, M. Amélia. "A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging: solution and in vivo studies of 67Ga-labeled species". Journal of Inorganic Biochemistry 105 1 (2011): 31-38.
    Publicado • 10.1016/j.jinorgbio.2010.09.012
  48. Silvério, Sara; Torres, Susana; Martins, André F.; Martins, José A.; André, João P.; Helm, Lothar; Prata, M. Isabel M.; Santos, Ana C.; Geraldes, Carlos F. G. C.. "Lanthanide chelates of (bis)-hydroxymethyl-substituted DTTA with potential application as contrast agents in magnetic resonance imaging". Dalton Transactions 24 (2009): 4656-4656.
    Publicado • 10.1039/b823402g
  49. Ferreira, Miguel F.; Martins, André F.; Martins, José A.; Ferreira, Paula M.; Tóth, Éva; Geraldes, Carlos F.G.C.. "Gd(DO3A-N-a-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents". Chemical Communications 42 (2009): 6475-6475.
    Publicado • 10.1039/b912201j
Capítulo de livro
  1. Freidel, L.; Li, S.; Choffart, A.; Kuebler, L.; Martins, A.F.. "Imaging Techniques in Pharmacological Precision Medicine". 213-235. 2023.
    10.1007/164_2023_641
Pré-impressão
  1. Remy Chiaffarelli; Pedro Cruz; Max Zimmermann; Carlos F. G. C. Geraldes; Paul Jurek; Andre F. Martins. "Metabolic PCTA-Based Shift Reagents for the Selective Detection of Extracellular Lactate Using CEST MRI". 2024. https://doi.org/10.1101/2024.07.09.602789.
    10.1101/2024.07.09.602789

Propriedade Intelectual

Patente
  1. Mn(II)-based sensors to detect zinc in vivo with MRI. 2024. "Chirayl S, Martins AF, Clavijo-Jordan V, Sherry AD. Mn(II)-based sensors to detect zinc in vivo with MRI". Estados Unidos.
    Concedida/Emitida
  2. Namini Paranawithana; AF Martins; Sherry AD. 2021. "A pH-sensitive MRI Contrast Agent-Based on GdDOTA-Monoamide Methylene Phosphate". Estados Unidos.
    Concedida/Emitida
  3. AF Martins. 2019. "Zinc sensors for in vivo imaging of ¿-cell function by MRI". Estados Unidos.
    Concedida/Emitida

Outros

Outra produção
  1. Acidosis-mediated increase in IFN-¿-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors. 2023. Knopf, P.; Stowbur, D.; Hoffmann, S.H.L.; Hermann, N.; Maurer, A.; Buchner, V.; Poxleitner, M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85167648221&partnerID=MN8TOARS.
    10.21203/rs.3.rs-2816652/v1
  2. Using Micro-Synchrotron Radiation X-Ray Fluorescence (¿-Srxrf) for Trace Metal Imaging in the Development of MRI Contrast Agents for Prostate Cancer Imaging. 2022. Dao, E.; Jordan, M.V.C.; Geraki, K.; Martins, A.F.; Chirayil, S.; Sherry, A.D.; Farquharson, M.J.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85176982380&partnerID=MN8TOARS.
    10.2139/ssrn.4007848
  3. A protein-based biosensor for detecting calcium by magnetic resonance imaging. 2021. Ozbakir, H.F.; Miller, A.D.C.; Fishman, K.B.; Martins, A.F.; Kippin, T.E.; Mukherjee, A.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102224629&partnerID=MN8TOARS.
    10.1101/2021.02.04.429691
  4. A manganese(II)-Based Responsive Contrast Agent Detects Glucose- Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.. 2020. Chirayil, S.; Jordan, V.C.; Martins, A.F.; Paranawithana, N.; Ratnakar, S.J.; Sherry, A.D.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098900679&partnerID=MN8TOARS.
    10.26434/chemrxiv.12430082.v1
  5. A responsive MRI contrast agent for detection of excess copper(II) in the liver in vivo. 2018. Paranawithana, N.N.; Martins, A.F.; Clavijo-Jordan, V.; Zhao, P.; Chirayil, S.; Meloni, G.; Dean Sherry, A.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095659776&partnerID=MN8TOARS.
    10.26434/chemrxiv.7359095.v1
Atividades

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2007 - 2007 Vitor Madeira Conference
Conferência (Outra)
 NEBIOQ-AAC, Portugal
2007 - 2007 Nanotechnology
Simpósio (Outra)
 NEBIOQ, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2019 - Atual European Molecular Imaging Meeting

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2025/01/01 - Atual NPJ Imaging (2948-197X) Nature Springer
2020 - Atual Pharmaceuticals (1424-8247) MDPI AG
2019 - Atual Metabolites (2218-1989) MDPI AG
2013/07/20 - 2013/08/20 mRNA

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2024/12/01 - Atual FCT
Especialista
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia

Membro de associação

Nome da associação Tipo de participação
2004 - 2013 mRNA (NEBIOQ)
2010 - 2012 ANBIOQ
2008 - 2010 ANBIOQ
2007 - 2008 Academic Student Assotiation (AAC)
2006 - 2007 NEBIOQ
2006 - 2007 University Senate

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2020 - Atual Tubingen-Nothingahm Alliance
Membro
 Eberhard Karls Universität Tübingen, Alemanha

University of Nottingham, Reino Unido
Distinções

Prémio

2024 Innovation Award “HYPERBOLIC”, DKTK, Germany
Deutsches Konsortium für Translationale Krebsforschung, Alemanha
2024 “Leme do Ano” Excellence and Recognition, Award, City Aveiro, Portugal
Câmara Municipal de Aveiro, Portugal
2021 Dr. K. H. Eberle Preise/Dr. K. H. Eberle Stiftung, Germany
2020 Sofja Kovalevskaja Award 2020
Alexander von Humboldt-Stiftung, Alemanha
2018 Best Presentation Award
International Society for Magnetic Resonance in Medicine, Estados Unidos
2018 Seal of Excellence, Horizon 2020, European Commission
Conseil de l'Union Europeenne, Bélgica
2017 Travel award, World Molecular Imaging Society
World Molecular Imaging Society, Estados Unidos

Título

2025 Elected Board Member, ESMI, European Society for Molecular Imaging
European Society for Molecular Imaging , Alemanha
2022 W3-Professor in Advanced Preclinical Imaging and Cell Engineering/Humboldt Foundation, University of Tübingen, Tübingen, Germany
Eberhard Karls Universität Tübingen, Alemanha
2022 Deputy elected Associate PI assembly, iFIT Cluster of Excellence/Deutsche Forschungsgemeinschaft (DFG), Germany
Deutsche Forschungsgemeinschaft, Alemanha
2019 Junior Academy Member of the Faculty of Medicine, University of Tuebingen
Eberhard Karls Universität Tübingen, Alemanha
2017 Chair at the Annual ACS Meeting San Francisco
American Chemical Society, Estados Unidos

Outra distinção

2017 Qualification Maitre de Conférences Section 64
Gouvernement francais Ministere de l'education nationale, França
2012 Biotechnocentre Best Poster Presentation Award (France)
Region Centre, Portugal
2011 ESMI Poster Award within the category “Probe Design” in the field of Molecular Imaging (The Netherlands)
ESMI, Portugal
1996 National Vice Champion in Canoeing K1 Cadet
FPC, Portugal