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Present position: Director of the DNRF Center for Chromosome Stability, and Professor of Molecular Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark. Educational qualifications: Doctor of Philosophy, ICI CASE Studentship with Prof. P.T. Emmerson and Dr. K. Powell, Universities of Newcastle and Leicester /ICI Laboratories Billingham/Alderley Park 1982. Lectures on Masters and PhD courses in both the Health and Medical Sciences and the Science Facilities of the University of Copenhagen. Supervises clinical and non-clinical trainees in order for them to obtain a postgraduate research qualification. Has acted as the primary supervisor of 36 completed PhD students (+2 ongoing). Full CV can be consulted here: https://forskning.ku.dk/soeg/result/?pure=da%2Fpersons%2Fian-david-hickson(d315630a-fa9b-45cf-ab1d-0415f7774515)%2Fcv.html
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Identificação

Identificação pessoal

Nome completo
Ian Hickson

Nomes de citação

  • Hickson, Ian
  • Hickson, Ian David

Identificadores de autor

Ciência ID
6E15-89AB-4155
ORCID iD
0000-0002-0583-566X

Websites

Formação
Grau Classificação
1982
Concluído
 PhD (Doctor of Philosophy)
Newcastle University, Reino Unido
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2010 - Atual Investigador principal (carreira) (Investigação) Kobenhavns Universitet Institut for Cellular og Molekylar Medicin, Dinamarca
Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen , Dinamarca
1999 - 2010 Investigador Coordenador (carreira) (Investigação) Cancer Research UK, Reino Unido
Cancer Research UK, Reino Unido
1989 - 1999 Investigador Contratado (Investigação) Weatherall Institute of Molecular Medicine, Reino Unido
Weatherall Institute of Molecular Medicine Oncology, Reino Unido

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
1983 - 1989 Leitor (Docente Universitário) Newcastle University, Reino Unido
Projetos

Bolsa

Designação Financiadores
2015/03 - 2025/02 Establishment of the Center for Chromosome Stability
DNRF115
 National Research Foundation
2019 - 2023 AntiHelix
na
Investigador responsável
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2019 - 2022 ChromoCapture: a pioneering chromosome analysis platform for interrogation of disease etiology
na
Investigador responsável
Novo Nordisk
2018 - 2020 Understanding how aneuploidy drives tumorigenesis
na
Investigador responsável
Medical Research Council - Denmark
2016 - 2019 Centromeric heterochromatin and the maintenance of chromosome stability
na
Investigador responsável
Lundbeckfonden

Outro

Designação Financiadores
2019 - 2022 Nordea Foundation Center for Healthy Aging – Core Support
na
Outra
Nordea Foundation
2019 - 2019 Carlsberg Foundation - Infrastructure Grant
na
Investigador responsável
Carlsbergfondet
Produções

Publicações

Artigo em revista
  1. Julia A. M. Bakx; Andreas S. Biebricher; Graeme A. King; Panagiotis Christodoulis; Kata Sarlós; Anna H. Bizard; Ian D. Hickson; Gijs J. L. Wuite; Erwin J. G. Peterman. "Duplex DNA and BLM regulate gate opening by the human TopoIIIa-RMI1-RMI2 complex". Nature Communications 13 1 (2022): https://doi.org/10.1038/s41467-022-28082-5.
    10.1038/s41467-022-28082-5
  2. Geng, Xinwei; Zhang, Chao; Li, Miao; Wang, Jiaqi; Ji, Fang; Feng, Hanrong; Xing, Meichun; et al. "PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response". Advanced Science (2022): 2103837. http://dx.doi.org/10.1002/advs.202103837.
    10.1002/advs.202103837
  3. Meijering, A.E.C.; Sarlos, K.; Nielsen, C.F.; Witt, H.; Harju, J.; Kerklingh, E.; Haasnoot, G.H.; et al. Autor correspondente: Hickson, I.D.. "Nonlinear mechanics of human mitotic chromosomes.". Nature (2022):
    No prelo
  4. Wu, W.; Bhowmick, R.; Vogel, I.; Özer, Ö.; Ghisays, F.; Thakur, R.S.; Sanchez de Leon, E.; et al. "RTEL1 suppresses G-quadruplex-associated R-loops at difficult-to-replicate loci in the human genome". Nature Structural and Molecular Biology 27 5 (2020): 424-437. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084442515&partnerID=MN8TOARS.
    10.1038/s41594-020-0408-6
  5. Venegas, A.B.; Natsume, T.; Kanemaki, M.; Hickson, I.D.. "Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase". Cell Reports 31 3 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85083288723&partnerID=MN8TOARS.
    10.1016/j.celrep.2020.107533
  6. Durhuus, J.A.; Hansson, S.; Morville, T.; Kuhlman, A.B.; Dohlmann, T.L.; Larsen, S.; Helge, J.W.; et al. "Simvastatin improves mitochondrial respiration in peripheral blood cells". Scientific Reports 10 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85092466764&partnerID=MN8TOARS.
    10.1038/s41598-020-73896-2
  7. Brannvoll, A.; Xue, X.; Kwon, Y.; Kompocholi, S.; Simonsen, A.K.W.; Viswalingam, K.S.; Gonzalez, L.; et al. "The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells". Cell Reports 32 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85087423923&partnerID=MN8TOARS.
    10.1016/j.celrep.2020.107849
  8. Xing, M.; Zhang, F.; Liao, H.; Chen, S.; Che, L.; Wang, X.; Bao, Z.; et al. "Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes". Molecular Cell 78 4 (2020): 714-724.e5. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084637323&partnerID=MN8TOARS.
    10.1016/j.molcel.2020.04.005
  9. Bizard, A.H.; Hickson, I.D.. "The many lives of type IA topoisomerases". Journal of Biological Chemistry 295 20 (2020): 7138-7153. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084787153&partnerID=MN8TOARS.
    10.1074/jbc.REV120.008286
  10. Macheret, M.; Bhowmick, R.; Sobkowiak, K.; Padayachy, L.; Mailler, J.; Hickson, I.D.; Halazonetis, T.D.. "High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing". Cell Research 30 11 (2020): 997-1008. http://www.scopus.com/inward/record.url?eid=2-s2.0-85086571711&partnerID=MN8TOARS.
    10.1038/s41422-020-0358-x
  11. Carbone, M.; Arron, S.T.; Beutler, B.; Bononi, A.; Cavenee, W.; Cleaver, J.E.; Croce, C.M.; et al. "Tumour predisposition and cancer syndromes as models to study gene–environment interactions". Nature Reviews Cancer 20 9 (2020): 533-549. http://www.scopus.com/inward/record.url?eid=2-s2.0-85085697743&partnerID=MN8TOARS.
    10.1038/s41568-020-0265-y
  12. Garribba, L.; Bjerregaard, V.A.; Gonçalves Dinis, M.M.; Özer, Ö.; Wu, W.; Sakellariou, D.; Pena-Diaz, J.; Hickson, I.D.; Liu, Y.. "Folate stress induces SLX1- And RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells". Proceedings of the National Academy of Sciences of the United States of America 117 28 (2020): 16527-16536. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088177764&partnerID=MN8TOARS.
    10.1073/pnas.1921219117
  13. Jørgensen, S.W.; Liberti, S.E.; Larsen, N.B.; Lisby, M.; Mankouri, H.W.; Hickson, I.D.. "Esc2 promotes telomere stability in response to DNA replication stress". Nucleic Acids Research 47 9 (2019): 4597-4611. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066028497&partnerID=MN8TOARS.
    10.1093/nar/gkz158
  14. Zhang, B.N.; Bueno Venegas, A.; Hickson, I.D.; Chu, W.K.. "DNA replication stress and its impact on chromosome segregation and tumorigenesis". Seminars in Cancer Biology 55 (2019): 61-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046161578&partnerID=MN8TOARS.
    10.1016/j.semcancer.2018.04.005
  15. Taylor, A.M.R.; Rothblum-Oviatt, C.; Ellis, N.A.; Hickson, I.D.; Meyer, S.; Crawford, T.O.; Smogorzewska, A.; et al. "Chromosome instability syndromes". Nature Reviews Disease Primers 5 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072400751&partnerID=MN8TOARS.
    10.1038/s41572-019-0113-0
  16. Achuthankutty, D.; Thakur, R.S.; Haahr, P.; Hoffmann, S.; Drainas, A.P.; Bizard, A.H.; Weischenfeldt, J.; Hickson, I.D.; Mailand, N.. "Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability". Journal of Cell Biology 218 12 (2019): 3943-3953. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075959276&partnerID=MN8TOARS.
    10.1083/JCB.201905064
  17. Sonneville, R.; Bhowmick, R.; Hoffmann, S.; Mailand, N.; Hickson, I.D.; Labib, K.. "TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication". eLife 8 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072849255&partnerID=MN8TOARS.
    10.7554/eLife.48686
  18. Bhowmick, R.; Thakur, R.S.; Venegas, A.B.; Liu, Y.; Nilsson, J.; Barisic, M.; Hickson, I.D.. "The RIF1-PP1 Axis Controls Abscission Timing in Human Cells". Current Biology 29 7 (2019): 1232-1242.e5. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063395251&partnerID=MN8TOARS.
    10.1016/j.cub.2019.02.037
  19. Bizard, A.H.; Allemand, J.-F.; Hassenkam, T.; Paramasivam, M.; Sarlós, K.; Singh, M.I.; Hickson, I.D.. "PICH and TOP3A cooperate to induce positive DNA supercoiling". Nature Structural and Molecular Biology 26 4 (2019): 267-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063740249&partnerID=MN8TOARS.
    10.1038/s41594-019-0201-6
  20. Bizard, A.H.; Hickson, I.D.. "Anaphase: a fortune-teller of genomic instability". Current Opinion in Cell Biology 52 (2018): 112-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043327964&partnerID=MN8TOARS.
    10.1016/j.ceb.2018.02.012
  21. Özer, O.; Hickson, I.D.. "Pathways for maintenance of telomeres and common fragile sites during DNA replication stress". Open Biology 8 4 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85055413808&partnerID=MN8TOARS.
    10.1098/rsob.180018
  22. Martin, C.-A.; Sarlós, K.; Logan, C.V.; Thakur, R.S.; Parry, D.A.; Bizard, A.H.; Leitch, A.; et al. "Erratum: Mutations in TOP3A Cause a Bloom Syndrome-like Disorder (The American Journal of Human Genetics (2018) 103(2) (221–231), (S0002929718302283) (10.1016/j.ajhg.2018.07.001))". American Journal of Human Genetics 103 3 (2018): 456-456. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052622881&partnerID=MN8TOARS.
    10.1016/j.ajhg.2018.08.012
  23. Bjerregaard, V.A.; Garribba, L.; McMurray, C.T.; Hickson, I.D.; Liu, Y.. "Folate deficiency drives mitotic missegregation of the human FRAXA locus". Proceedings of the National Academy of Sciences of the United States of America 115 51 (2018): 13003-13008. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058714119&partnerID=MN8TOARS.
    10.1073/pnas.1808377115
  24. Sarlós, K.; Biebricher, A.S.; Bizard, A.H.; Bakx, J.A.M.; Ferreté-Bonastre, A.G.; Modesti, M.; Paramasivam, M.; et al. "Reconstitution of anaphase DNA bridge recognition and disjunction". Nature Structural and Molecular Biology 25 9 (2018): 868-876. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052987271&partnerID=MN8TOARS.
    10.1038/s41594-018-0123-8
  25. Martin, C.-A.; Sarlós, K.; Logan, C.V.; Thakur, R.S.; Parry, D.A.; Bizard, A.H.; Leitch, A.; et al. "Mutations in TOP3A Cause a Bloom Syndrome-like Disorder". American Journal of Human Genetics 103 2 (2018): 221-231. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052988354&partnerID=MN8TOARS.
    10.1016/j.ajhg.2018.07.001
  26. Özer, Ö.; Bhowmick, R.; Liu, Y.; Hickson, I.D.. "Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism". Oncotarget 9 22 (2018): 15836-15846. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044358904&partnerID=MN8TOARS.
    10.18632/oncotarget.24745
  27. Bizard, A.H.; Nielsen, C.F.; Hickson, I.D.. "Erratum to: Detection of Ultrafine Anaphase Bridges". Methods in molecular biology (Clifton, N.J.) 1672 (2018): E1-E1. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077276500&partnerID=MN8TOARS.
    10.1007/978-1-4939-7306-4_43
  28. Albers, E.; Sbroggiò, M.; Pladevall-Morera, D.; Bizard, A.H.; Avram, A.; Gonzalez, P.; Martin-Gonzalez, J.; Hickson, I.D.; Lopez-Contreras, A.J.. "Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality". Cell Reports 24 12 (2018): 3274-3284. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053129944&partnerID=MN8TOARS.
    10.1016/j.celrep.2018.08.071
  29. Rahul Bhowmick; Ian D Hickson. "The "enemies within": regions of the genome that are inherently difficult to replicate [version 1; referees: awaiting peer review]". (2017): https://f1000research.com/articles/6-666/v1.
    10.12688/f1000research.11024.1
  30. Sarlós, K.; Biebricher, A.; Petermann, E.J.G.; Wuite, G.J.L.; Hickson, I.D.. "Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase". Cold Spring Harbor symposia on quantitative biology 82 (2017): 187-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052988377&partnerID=MN8TOARS.
    10.1101/sqb.2017.82.033647
  31. Pitchai, G.P.; Kaulich, M.; Bizard, A.H.; Mesa, P.; Yao, Q.; Sarlos, K.; Streicher, W.W.; et al. "A novel TPR-BEN domain interaction mediates PICH-BEND3 association". Nucleic Acids Research 45 19 (2017): 11413-11424. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038003930&partnerID=MN8TOARS.
    10.1093/nar/gkx792
  32. Natsume, T.; Nishimura, K.; Minocherhomji, S.; Bhowmick, R.; Hickson, I.D.; Kanemaki, M.T.. "Acute inactivation of the replicative helicase in human cells triggers MCM8–9-dependent DNA synthesis". Genes and Development 31 8 (2017): 816-829. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019841603&partnerID=MN8TOARS.
    10.1101/gad.297663.117
  33. Larsen, N.B.; Liberti, S.E.; Vogel, I.; Jørgensen, S.W.; Hickson, I.D.; Mankouri, H.W.. "Stalled replication forks generate a distinct mutational signature in yeast". Proceedings of the National Academy of Sciences of the United States of America 114 36 (2017): 9665-9670. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029230374&partnerID=MN8TOARS.
    10.1073/pnas.1706640114
  34. Ren, L.; Chen, L.; Wu, W.; Garribba, L.; Tian, H.; Liu, Z.; Vogel, I.; et al. "Potential biomarkers of DNA replication stress in cancer". Oncotarget 8 23 (2017): 36996-37008. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020187778&partnerID=MN8TOARS.
    10.18632/oncotarget.16940
  35. Di Marco, S.; Hasanova, Z.; Kanagaraj, R.; Chappidi, N.; Altmannova, V.; Menon, S.; Sedlackova, H.; et al. "RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis". Molecular Cell 66 5 (2017): 658-671.e8. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020070786&partnerID=MN8TOARS.
    10.1016/j.molcel.2017.05.006
  36. Nielsen, C.F.; Hickson, I.D.. "PICH promotes mitotic chromosome segregation: Identification of a novel role in rDNA disjunction". Cell Cycle 15 20 (2016): 2704-2711. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988380484&partnerID=MN8TOARS.
    10.1080/15384101.2016.1222336
  37. Pitchai, G.P.; Hickson, I.D.; Streicher, W.; Montoya, G.; Mesa, P.. "Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex". Acta Crystallographica Section:F Structural Biology Communications 72 (2016): 646-651. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982958255&partnerID=MN8TOARS.
    10.1107/S2053230X16010724
  38. Ghamrasni, S.E.; Cardoso, R.; Li, L.; Guturi, K.K.N.; Bjerregaard, V.A.; Liu, Y.; Venkatesan, S.; et al. "Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation". Oncogene 35 37 (2016): 4836-4845. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958074157&partnerID=MN8TOARS.
    10.1038/onc.2016.16
  39. Christensen, C.L.; Helge, J.W.; Krasnik, A.; Kriegbaum, M.; Rasmussen, L.J.; Hickson, I.D.; Liisberg, K.B.; et al. "LIFESTAT - Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction". Scandinavian Journal of Public Health 44 5 (2016): 534-539. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971454076&partnerID=MN8TOARS.
    10.1177/1403494816636304
  40. Ahuja, A.K.; Jodkowska, K.; Teloni, F.; Bizard, A.H.; Zellweger, R.; Herrador, R.; Ortega, S.; et al. "A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells". Nature Communications 7 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84958530589&partnerID=MN8TOARS.
    10.1038/ncomms10660
  41. Bhowmick, R.; Minocherhomji, S.; Hickson, I.D.. "RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress". Molecular Cell 64 6 (2016): 1117-1126. http://www.scopus.com/inward/record.url?eid=2-s2.0-85008198175&partnerID=MN8TOARS.
    10.1016/j.molcel.2016.10.037
  42. Bursomanno, S.; McGouran, J.F.; Kessler, B.M.; Hickson, I.D.; Liu, Y.. "Regulation of SUMO2 target proteins by the proteasome in human cells exposed to replication stress". Journal of Proteome Research 14 4 (2015): 1687-1699. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926443749&partnerID=MN8TOARS.
    10.1021/pr500997p
  43. Xing, M.; Wang, X.; Palmai-Pallag, T.; Shen, H.; Helleday, T.; Hickson, I.D.; Ying, S.. "Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response". Oncotarget 6 35 (2015): 37638-37646. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947746631&partnerID=MN8TOARS.
    10.18632/oncotarget.5497
  44. Kliszczak, M.; Sedlackova, H.; Pitchai, G.P.; Streicher, W.W.; Krejci, L.; Hickson, I.D.. "Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells". Oncotarget 6 38 (2015): 40464-40479. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951098354&partnerID=MN8TOARS.
    10.18632/oncotarget.6342
  45. Bursomanno, S.; Beli, P.; Khan, A.M.; Minocherhomji, S.; Wagner, S.A.; Bekker-Jensen, S.; Mailand, N.; et al. "Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells". DNA Repair 25 (2015): 84-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-84917705873&partnerID=MN8TOARS.
    10.1016/j.dnarep.2014.10.011
  46. Newman, J.A.; Savitsky, P.; Allerston, C.K.; Bizard, A.H.; Özer, Ö.; Sarlós, K.; Liu, Y.; et al. "Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes". Nucleic Acids Research 43 10 (2015): 5221-5235. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931275195&partnerID=MN8TOARS.
    10.1093/nar/gkv373
  47. Nielsen, C.F.; Huttner, D.; Bizard, A.H.; Hirano, S.; Li, T.-N.; Palmai-Pallag, T.; Bjerregaard, V.A.; et al. "PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis". Nature Communications 6 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84949522676&partnerID=MN8TOARS.
    10.1038/ncomms9962
  48. Chu, W.K.; Payne, M.J.; Beli, P.; Hanada, K.; Choudhary, C.; Hickson, I.D.. "FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51". Nature Communications 6 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84923095162&partnerID=MN8TOARS.
    10.1038/ncomms6931
  49. Minocherhomji, S.; Ying, S.; Bjerregaard, V.A.; Bursomanno, S.; Aleliunaite, A.; Wu, W.; Mankouri, H.W.; et al. "Replication stress activates DNA repair synthesis in mitosis". Nature 528 7581 (2015): 286-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949790002&partnerID=MN8TOARS.
    10.1038/nature16139
  50. Fugger, K.; Mistrik, M.; Neelsen, K.J.; Yao, Q.; Zellweger, R.; Kousholt, A.N.; Haahr, P.; et al. "FBH1 catalyzes regression of stalled replication forks". Cell Reports 10 10 (2015): 1749-1757. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925216841&partnerID=MN8TOARS.
    10.1016/j.celrep.2015.02.028
  51. Chatterjee, S.; Zagelbaum, J.; Savitsky, P.; Sturzenegger, A.; Huttner, D.; Janscak, P.; Hickson, I.D.; Gileadi, O.; Rothenberg, E.. "Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures". Nature Communications 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84923326943&partnerID=MN8TOARS.
    10.1038/ncomms6556
  52. Larsen, N.B.; Hickson, I.D.; Mankouri, H.W.. "Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes". Cell Cycle 13 19 (2014): 2994-2998. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927564244&partnerID=MN8TOARS.
    10.4161/15384101.2014.958912
  53. Nguyen, G.H.; Tang, W.; Robles, A.I.; Beyer, R.P.; Gray, L.T.; Welsh, J.A.; Schetter, A.J.; et al. "Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs". Proceedings of the National Academy of Sciences of the United States of America 111 27 (2014): 9905-9910. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903973907&partnerID=MN8TOARS.
    10.1073/pnas.1404807111
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  237. Carmichael, J.; Hickson, I.D.. "Keynote address: Mechanisms of cellular resistance to cytotoxic drugs and X-irradiation". International Journal of Radiation Oncology, Biology, Physics 20 2 (1991): 197-202. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026028776&partnerID=MN8TOARS.
    10.1016/0360-3016(91)90089-M
  238. Robson, C.N.; Milne, A.M.; Pappin, D.J.C.; Hickson, I.D.. "Isolation of cDNA clones encoding an enzyme from bovine cells that repairs oxidative DNA damage in vitro: Homology with bacterial repair enzymes". Nucleic Acids Research 19 5 (1991): 1087-1092. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026070597&partnerID=MN8TOARS.
    10.1093/nar/19.5.1087
  239. Papathanasiou, M.A.; Kerr, N.C.K.; Robbins, J.H.; McBride, O.W.; Alamo Jr., I.; Barrett, S.F.; Hickson, I.D.; Fornace Jr., A.J.. "Induction by ionizing radiation of the gadd45 gene in cultured human cells: Lack of mediation by protein kinase C". Molecular and Cellular Biology 11 2 (1991): 1009-1016. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026021668&partnerID=MN8TOARS.
    10.1128/MCB.11.2.1009
  240. Bligh, H.F.J.; Beggs, J.D.; Bartoszek, A.; Wolf, C.R.; Robson, C.N.; Hickson, I.D.; Kasper, C.B.. "Activation of Mitomycin C by NADPH:Cytochrome P-450 Reductase". Cancer Research 50 24 (1990): 7789-7792. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025673868&partnerID=MN8TOARS.
  241. Hoban, P.R.; Walton, M.I.; Robson, C.N.; Godden, J.; Stratford, I.J.; Workman, P.; Harris, A.L.; Hickson, I.D.. "Decreased NADPH: Cytochrome P-450 Reductase Activity and Impaired Drug Activation in a Mammalian Cell Line Resistant to Mitomycin C under Aerobic but not Hypoxic Conditions". Cancer Research 50 15 (1990): 4692-4697. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025352024&partnerID=MN8TOARS.
  242. Davies, S.M.; Davies, S.L.; Hall, A.G.; Hickson, I.D.. "Isolation and partial characterisation of a mammalian cell mutant hypersensitive to topoisomerase II inhibitors and X-rays". Mutation Research-DNA Repair 235 2 (1990): 111-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025129196&partnerID=MN8TOARS.
    10.1016/0921-8777(90)90064-C
  243. Hickson, I.D.; Davies, S.L.; Davies, S.M.; Robson, C.N.. "DNA repair in radiation sensitive mutants of mammalian cells: Possible involvement of DNA topoisomerases". International Journal of Radiation Biology 58 4 (1990): 561-568. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025006831&partnerID=MN8TOARS.
    10.1080/09553009014551921
  244. Robson, C.N.; Harris, A.L.; Hickson, I.D.. "Defective repair of DNA single- and double-strand breaks in the bleomycin- and X-ray-sensitive Chinese hamster ovary cell mutant, BLM-2". Mutation Research-DNA Repair 217 2 (1989): 93-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024535313&partnerID=MN8TOARS.
    10.1016/0921-8777(89)90060-8
  245. Stratford, I.J.; Hickson, I.D.; Robson, C.N.; Stephens, M.. "Radiosensitizing and cytotoxic effects of nitroimidazoles in CHO cells expressing elevated levels of glutathione-S-transferase". International Journal of Radiation Oncology, Biology, Physics 16 5 (1989): 1307-1310. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024311895&partnerID=MN8TOARS.
    10.1016/0360-3016(89)90304-0
  246. Davies, S.M.; Davies, S.L.; Harris, A.L.; Hickson, I.D.. "Isolation of Two Chinese Hamster Ovary Cell Mutants Hypersensitive to Topoisomerase II Inhibitors and Cross-Resistant to Peroxides". Cancer Research 49 16 (1989): 4526-4530. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024312142&partnerID=MN8TOARS.
  247. Hall, A.; Proctor, S.J.; Cattan, A.R.; Robson, C.N.; Hickson, I.D.; Harris, A.L.. "Possible Role of Inhibition of Glutathione S-Transferase in the Partial Reversal of Chlorambucil Resistance by Indomethacin in a Chinese Hamster Ovary Cell Line". Cancer Research 49 22 (1989): 6265-6268. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024311015&partnerID=MN8TOARS.
  248. Davies, S.M.; Harris, A.L.; Hickson, I.D.. "Overproduction of topoisomerase II in an ataxia telangiectasia fibroblast cell line: Comparison with a topoisomerase II-overproducing hamster cell mutant". Nucleic Acids Research 17 4 (1989): 1337-1351. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024536961&partnerID=MN8TOARS.
    10.1093/nar/17.4.1337
  249. Davies, S.M.; Robson, C.N.; Davies, S.L.; Hickson, I.D.. "Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins". Journal of Biological Chemistry 263 33 (1988): 17724-17729. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024261519&partnerID=MN8TOARS.
  250. Hickson, I.D.; Harris, A.L.. "Mammalian DNA repair - use of mutants hypersensitive to cytotoxic agents". Trends in Genetics 4 4 (1988): 101-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023914684&partnerID=MN8TOARS.
    10.1016/0168-9525(88)90097-2
  251. Lewis, A.D.; Hickson, I.D.; Robson, C.N.; Harris, A.L.; Hayes, J.D.; Griffiths, S.A.; Manson, M.M.; et al. "Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards". Proceedings of the National Academy of Sciences of the United States of America 85 22 (1988): 8511-8515. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345083688&partnerID=MN8TOARS.
    10.1073/pnas.85.22.8511
  252. Robson, C.N.; Hall, A.; Harris, A.L.; Hickson, I.D.. "Bleomycin and X-ray-hypersensitive Chinese hamster ovary cell mutants: Genetic analysis and cross-resistance to neocarzinostatin". Mutation Research DNA Repair Reports 193 2 (1988): 157-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023906386&partnerID=MN8TOARS.
    10.1016/0167-8817(88)90046-6
  253. Robson, C.N.; Lewis, A.D.; Wolf, C.R.; Hayes, J.D.; Hall, A.; Proctor, S.J.; Harris, A.L.; Hickson, I.D.. "Reduced Levels of Drug-induced DNA Cross-Linking in Nitrogen Mustard-resistant Chinese Hamster Ovary Cells Expressing Elevated Glutathione S-Transferase Activity". Cancer Research 47 22 (1987): 6022-6027. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023554666&partnerID=MN8TOARS.
  254. Robson, C.N.; Hoban, P.R.; Harris, A.L.; Hickson, I.D.. "Cross-sensitivity to topoisomerase II inhibitors in cytotoxic drug-hypersensitive chinese hamster ovary cell lines". Cancer Research 47 6 (1987): 1560-1565. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023097221&partnerID=MN8TOARS.
  255. Robson, C.N.; Hickson, I.D.. "Isolation of alkylating agent-sensitive chinese hamster ovary cell lines". Carcinogenesis 8 4 (1987): 601-605. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023269180&partnerID=MN8TOARS.
    10.1093/carcin/8.4.601
  256. Brown, K.; Finch, P.W.; Hickson, I.D.; Emmerson, P.T.. "Complete nucleotide sequence of the Escherichia coli argA gene". Nucleic Acids Research 15 24 (1987): 10586-10586. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023663222&partnerID=MN8TOARS.
    10.1093/nar/15.24.10586
  257. Finch, P.W.; Wilson, R.E.; Brown, K.; Hickson, I.D.; Tomkinson, A.E.; Emmerson, P.T.. "Complete nucleotide sequence of the Escherichia coti recC gene and of the thyA-recC intergenk region". Nucleic Acids Research 14 11 (1986): 4437-4451. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023046804&partnerID=MN8TOARS.
    10.1093/nar/14.11.4437
  258. Robson, C.N.; Alexander, J.; Harris, A.L.; Hickson, I.D.. "Isolation and characterization of a chinese hamster ovary cell line resistant to bifunctional nitrogen mustards". Cancer Research 46 (1986): 6290-6294. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022838278&partnerID=MN8TOARS.
  259. Finch, P.W.; Storey, A.; Chapman, K.E.; Brown, K.; Hickson, I.D.; Emmerson, P.T.. "Complete nucleotide sequence of the Escherichia coli recB gene". Nucleic Acids Research 14 21 (1986): 8573-8582. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023047199&partnerID=MN8TOARS.
    10.1093/nar/14.21.8573
  260. Robson, C.N.; Hickson, I.D.. "Genetic analysis of mitomycin C-sensitive mutants of a Chinese hamster ovary cell line". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 163 2 (1986): 201-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023038631&partnerID=MN8TOARS.
    10.1016/0027-5107(86)90049-7
  261. Finch, P.W.; Wilson, R.E.; Brown, K.; Hickson, I.D.; Emmerson, P.T.. "Complete nucleotide sequence of the Escherichia coli ptr gene encoding protease III". Nucleic Acids Research 14 19 (1986): 7695-7703. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023046298&partnerID=MN8TOARS.
    10.1093/nar/14.19.7695
  262. Robson, C.N.; Harris, A.L.; Hickson, I.D.. "Isolation and Characterization of Chinese Hamster Ovary Cell Lines Sensitive to Mitomycin C and Bleomycin". Cancer Research 45 (1985): 5304-5309. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022382204&partnerID=MN8TOARS.
  263. Hickson, I.D.; Robson, C.N.; Atkinson, K.E.; Hutton, L.; Emmerson, P.T.. "Reconstitution of RecBC DNase activity from purified Escherichia coli RecB and RecC proteins". Journal of Biological Chemistry 260 2 (1985): 1224-1229. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021970716&partnerID=MN8TOARS.
  264. Hickson, I.D.; Atkinson, K.E.; Hutton, L.; Tomkinson, A.E.; Emmerson, P.T.. "Molecular amplification and purification of the E. colt recC gene product". Nucleic Acids Research 12 9 (1984): 3807-3819. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021760352&partnerID=MN8TOARS.
    10.1093/nar/12.9.3807
  265. Emmerson, P.T.; Hickson, I.D.; Arthur, H.M.; Atkinson, K.E.; Bramhill, D.; Finch, P.; Hutton, L.. "Use of recombinant DNA techniques to study DNA repair in Escherichia coli.". Biochemical Society transactions 12 2 (1984): 218-220. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021414307&partnerID=MN8TOARS.
    10.1042/bst0120218
  266. Hickson, I.D.; Emmerson, P.T.. "Involvement of recB and recC genes of Escherichia coli in precise transposon excision". Journal of Bacteriology 156 2 (1983): 901-903. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021049753&partnerID=MN8TOARS.
  267. Hickson, I.D.; Arthur, H.M.; Bramhill, D.; Emmerson, P.T.. "The E. coli uvrD gene product is DNA helicase II". MGG Molecular & General Genetics 190 2 (1983): 265-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020619679&partnerID=MN8TOARS.
    10.1007/BF00330649
  268. Hickson, I.D.; Atkinson, K.E.; Emmerson, P.T.. "Molecular cloning and amplification of the gene for thymidylate synthetase of E. coli". Gene 18 3 (1982): 257-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020428103&partnerID=MN8TOARS.
    10.1016/0378-1119(82)90163-9
  269. Hickson, I.D.; Atkinson, K.E.; Emmerson, P.T.. "Construction of recombinant ¿ phages that carry the E. coli recB and recC genes". MGG Molecular & General Genetics 185 1 (1982): 148-151. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020028496&partnerID=MN8TOARS.
    10.1007/BF00333805
  270. Hickson, I.D.; Emmerson, P.T.. "Identification of the Escherichia coli recB and recC gene products". Nature 294 5841 (1981): 578-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019770947&partnerID=MN8TOARS.
    10.1038/294578a0
  271. Hickson, I.D.; Gordon, R.L.; Tomkinson, A.E.; Emmerson, P.T.. "A temperature sensitive RecA protein of Escherichia coli". MGG Molecular & General Genetics 184 1 (1981): 68-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019834431&partnerID=MN8TOARS.
    10.1007/BF00271197
Capítulo de livro
  1. Bjerregaard, V.A.; Özer, Ö.; Hickson, I.D.; Liu, Y.. "The detection and analysis of chromosome fragile sites". 471-482. 2018.
    10.1007/978-1-4939-7306-4_31
  2. Garribba, L.; Wu, W.; Özer, Ö.; Bhowmick, R.; Hickson, I.D.; Liu, Y.. "Inducing and Detecting Mitotic DNA Synthesis at Difficult-to-Replicate Loci". 45-58. 2018.
    10.1016/bs.mie.2017.11.025
  3. Bizard, A.H.; Nielsen, C.F.; Hickson, I.D.. "Detection of ultrafine anaphase bridges". 495-508. 2018.
    10.1007/978-1-4939-7306-4_33
  4. Larsen, N.B.; Hickson, I.D.; Mankouri, H.W.. "A molecular toolbox to engineer site-specific DNA replication perturbation". 295-309. 2018.
    10.1007/978-1-4939-7306-4_20
  5. Kessler, B.M.; Bursomanno, S.; McGouran, J.F.; Hickson, I.D.; Liu, Y.. "Biochemical and mass spectrometry-based approaches to profile sumoylation in human cells". 131-144. 2017.
    10.1007/978-1-4939-6439-0_10
  6. Huttner, D.; Hickson, I.D.. "Helicases". 406-408. 2013.
  7. Mosedale, G.; Hickson, I.D.. "RecQ Helicase Systems". 43-49. 2013.
Livro
  1. Larsen, N.B.; Hickson, I.D.. RecQ helicases: Conserved guardians of genomic integrity. 2013.
    10.1007/978-1-4614-5037-5_8
  2. Bachrati, C.Z.; Hickson, I.D.. Analysis of the DNA Unwinding Activity of RecQ Family Helicases. 2006.
    10.1016/S0076-6879(05)09005-1
  3. Wu, L.; Hickson, I.D.. DNA helicases required for homologous recombination and repair of damaged replication forks. 2006.
    10.1146/annurev.genet.40.110405.090636
  4. Norbury, C.J.; Hickson, I.D.. Cellular responses to DNA damage. 2001.
    10.1146/annurev.pharmtox.41.1.367
  5. Wu, L.; Davies, S.L.; Hickson, I.D.. Roles of RecQ family helicases in the maintenance of genome stability. 2000.
    10.1101/sqb.2000.65.573
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019 (2019/2020): 2019 FASEB Conference on ¿Genetic Recombination¿, Steamboat Springs, CO, USA (Symposium speaker) 2019 FASEB Conference on ¿DNA Helicases and Nucleic Acid Machines¿, Steamboat Springs, CO, USA (Symposium speaker). 2019 Basic Science Research Institute, Chengde Medical University, Hebei, China. 2019 Zhejiang University School of Medicine, Hangzhou, China. 2019 10th International Symposium on ¿DNA damage responses and human disease¿, Shenzhen, China (Keynote Speaker). 2020 University of Dundee Genome Stability Club, Dundee, UK.
2018 (2018 part I) 2018 A*Star Research Institute, Singapore. 2018 St Vincent’s Institute, Melbourne, Australia. 2018 Lorne Genome Conference, Lorne, Australia (Symposium Speaker). 2018 Children’s Medical Research Institute, Sydney, Australia. 2018 Institute of Cancer Research, London, UK. 2018 EMBO Symposium on ‘DNA Replication’, Heidelberg, Germany (Symposium speaker and Chair). 2018 14th Copenhagen Bioscience Conference on ‘Protein Signaling’, Favrholm, Denmark (Symposium speaker).
2018 (2018 part II) 2018 School of Life Sciences, Peking University, Beijing, China. 2018 7th icBEST Conference on ‘DNA damage responses’ Shenzhen, China (Symposium speaker). 2018 8th Weinman Symposium on ‘Cancer Predisposition Disorders’, University of Hawaii Cancer Center, Honolulu, Hawaii, USA (Symposium speaker). 2018 Friedrich Meicher Institute, Basel, Switzerland.
2017 2017 Institute of Genetics and Molecular Medicine, University of Edinburgh, UK 2017 Cold Spring Harbor Annual Meeting (Symposium Speaker). 2017 FUSION Conference on ‘DNA replication as a source of DNA damage’, Rome, Italy (Co-organizer, Symposium Speaker and Chair). 2017 EMBO Workshop on ‘DNA topoisomerases’, Les Diablerets, Switzerland (Invited Speaker). 2017 EMBO Conference on ‘DNA damage responses’, Athens, Greece (Invited Speaker). 2017 Zhejiang University School of Medicine, Hangzhou, China. 2017 Workshop on ‘DNA replication stress and hu
2016 2016 Abcam Conference on ‘Maintenance of Genome Stability’, Panama City, Panama (Symposium Speaker). 2016 99th Christian A. Herter Invited Lecture, New York University School of Medicine, USA. 2016 Abcam Conference on ‘Mechanisms of Genetic Recombination, Alicante, Spain (Symposium Speaker). 2016 Gordon Research Conference on ‘Mutagenesis and Genome Stability, Girona, Spain (Keynote Speaker and Session Chair). 2016 Mutation to Malignancy Symposium, University of Zurich, Switzerland (Symposium Speaker). 2016 Benzon Foundation Conference on ‘Gen

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
1989 - 2019 From 1989-2019 I have acted as the primary supervisor of 36 completed PhD students (+2 ongoing)
Orientador

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2013 - Atual Selected committee member activities (active in past 5 years) 2017-date Member of the advisory board of the Center for Integrative Microscopy, University of Copenhagen 2015-2018 Wellcome Trust (UK) Scientific Interview Panel Member 2014-date External Advisory Board Member of the UK Prostate Cancer Research Centre 2013-2015 ERC Consolidator Grants Evaluation Panel Member 2013-2016 Royal Society Research Grant Board Member (Biological Science)