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Identificação

Identificação pessoal

Nome completo
Ana Isabel Dias Neto Domingos

Nomes de citação

  • Domingos, Ana I

Identificadores de autor

Ciência ID
251E-E75B-E8AC
ORCID iD
0000-0002-7938-4814

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2000/11/01 - 2005/05/01
Concluído
 PhD Leslie Vosshall laboratory (Doktor (PhD))
The Rockefeller University, Estados Unidos
1995/09/01 - 1999/06/01
Concluído
 Matemática (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/09/01 - Atual Investigador Coordenador (carreira) (Investigação) University of Oxford Department of Physiology Anatomy and Genetics, Reino Unido
University of Oxford Department of Physiology Anatomy and Genetics, Reino Unido
2013/10/01 - Atual Investigador Auxiliar (carreira) (Investigação) Instituto Gulbenkian de Ciência, Portugal
2006/03/01 - 2013/09/30 Pós-doutorado (Investigação) The Rockefeller University, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2019/01 - 2024/12 Sympathetic and immune mechanisms underlying Obesity
ERC-2017-COG 771431
Investigador responsável
European Research Council, Bélgica
 European Research Council
Em curso
2017/09 - 2022/09 HHMI / Welcome International Research Scholar Award
208576/Z/17/Z
 Wellcome Trust
2016/05 - 2019/04 Neuroanatomy of fat discerned with whole body optoacoustic and fluorescence imaging
e1698963
 International Human Frontier Science Program Organization
2015/07 - 2018/06 Optogenetic dissection of neural circuits controlling adiposity
Provided by PTCRIS: 142379
 Fundação para a Ciência e a Tecnologia
2015/07 - 2018/06 Optogenetic dissection of neural circuits controlling adiposity
grant.Provided by PTCRIS: 142379
 Fundação para a Ciência e a Tecnologia
2013/07 - 2015/06 Molecular profiling of AGRP neurons and hyperphagia
Provided by PTCRIS: 126812
 Fundação para a Ciência e a Tecnologia
2013/07 - 2015/06 Molecular profiling of AGRP neurons and hyperphagia
grant.Provided by PTCRIS: 126812
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em conferência
  1. Voss, H.U.; Domingos, A.I.. "Analysis of coexisting neuronal populations in optogenetic and conventional BOLD data". 2012.
    10.1109/SPMB.2012.6469467
  2. Voss, H.U.; Ballon, D.J.; Domingos, A.I.. "Neuronal and hemodynamic source modeling of optogenetic BOLD signals". 2011.
    10.1109/SPMB.2011.6120104
Artigo em revista
  1. Cardoso F; Klein Wolterink RGJ; Godinho-Silva C; Domingues RG; Ribeiro H; da Silva JA; Mahú I; Domingos AI; Veiga-Fernandes H. "Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit.". Nature (2021): http://europepmc.org/abstract/med/34408322.
    10.1038/s41586-021-03830-7
  2. O'Brien CJO; Domingos AI. "An anti-obesity immunotherapy?". Science (New York, N.Y.) (2021): http://europepmc.org/abstract/med/34210864.
    10.1126/science.abj5072
  3. Larabee, C.M.; Neely, O.C.; Domingos, A.I.. "Obesity: a neuroimmunometabolic perspective". Nature Reviews Endocrinology 16 1 (2020): 30-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075687331&partnerID=MN8TOARS.
    10.1038/s41574-019-0283-6
  4. Domingos, A.I.. "Leptin: a missing piece in the immunometabolism puzzle". Nature Reviews Immunology 20 1 (2020): 3-3. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075527839&partnerID=MN8TOARS.
    10.1038/s41577-019-0251-3
  5. Badenes, M.; Amin, A.; González-García, I.; Félix, I.; Burbridge, E.; Cavadas, M.; Ortega, F.J.; et al. "Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis". Molecular Metabolism 31 (2020): 67-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075953290&partnerID=MN8TOARS.
    10.1016/j.molmet.2019.10.006
  6. Sarker, G.; Larabee, C.M.; Domingos, A.I.. "ILC3s gut rhythm". Nature Immunology (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077469634&partnerID=MN8TOARS.
    10.1038/s41590-019-0580-1
  7. Mahú, I.; Barateiro, A.; Rial-Pensado, E.; Martinéz-Sánchez, N.; Vaz, S.H.; Cal, P.M.S.D.; Jenkins, B.; et al. "Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects". Cell Metabolism (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085312788&partnerID=MN8TOARS.
    10.1016/j.cmet.2020.04.013
  8. Haberman, E.R.; Domingos, A.I.. "Illuminating Neuroimmunity: A Humoral Brain". Immunity 52 6 (2020): 900-902. http://www.scopus.com/inward/record.url?eid=2-s2.0-85086498811&partnerID=MN8TOARS.
    10.1016/j.immuni.2020.05.011
  9. Seoane-Collazo, P.; Liñares-Pose, L.; Rial-Pensado, E.; Romero-Picó, A.; Moreno-Navarrete, J.M.; Martínez-Sánchez, N.; Garrido-Gil, P.; et al. "Central nicotine induces browning through hypothalamic ¿ opioid receptor". Nature Communications 10 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071896682&partnerID=MN8TOARS.
    10.1038/s41467-019-12004-z
  10. Blankenhaus, B.; Braza, F.; Martins, R.; Bastos-Amador, P.; González-García, I.; Carlos, A.R.; Mahu, I.; et al. "Ferritin regulates organismal energy balance and thermogenesis". Molecular Metabolism 24 (2019): 64-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063740016&partnerID=MN8TOARS.
    10.1016/j.molmet.2019.03.008
  11. Berger, J.M.; Singh, P.; Khrimian, L.; Morgan, D.A.; Chowdhury, S.; Arteaga-Solis, E.; Horvath, T.L.; et al. "Mediation of the Acute Stress Response by the Skeleton". Cell Metabolism 30 5 (2019): 890-902.e8. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073686107&partnerID=MN8TOARS.
    10.1016/j.cmet.2019.08.012
  12. Pirzgalska, R.M.; Domingos, A.I.. "Macrophages in obesity". Cellular immunology 330 (2018): 183-187. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051648735&partnerID=MN8TOARS.
    10.1016/j.cellimm.2018.04.014
  13. Schneeberger, M.; Tan, K.; Nectow, A.R.; Parolari, L.; Caglar, C.; Azevedo, E.; Li, Z.; Domingos, A.; Friedman, J.M.. "Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons". Molecular Metabolism 13 (2018): 83-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047483129&partnerID=MN8TOARS.
    10.1016/j.molmet.2018.05.001
  14. Zufall, F.; Domingos, A.I.. "The structure of Orco and its impact on our understanding of olfaction". Journal of General Physiology 150 12 (2018): 1602-1605. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057770867&partnerID=MN8TOARS.
    10.1085/jgp.201812226
  15. Huang, W.; Thomas, B.; Flynn, R.A.; Gavzy, S.J.; Wu, L.; Kim, S.V.; Hall, J.A.; et al. "Erratum to: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions (Nature, (2015), 528, 7583, (517-522), 10.1038/nature16193)". Nature 562 7725 (2018): 150-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054338940&partnerID=MN8TOARS.
    10.1038/s41586-018-0311-z
  16. "Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine". Nature Medicine (2017): http://dx.doi.org/10.1038/nm.4422.
    10.1038/nm.4422
  17. Pereira, M.M.A.; Mahú, I.; Seixas, E.; Martinéz-Sánchez, N.; Kubasova, N.; Pirzgalska, R.M.; Cohen, P.; et al. "Corrigendum: A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages". Nature communications 8 (2017): 15673-15673. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056394541&partnerID=MN8TOARS.
    10.1038/ncomms15673
  18. Mahú, I.; Domingos, A.I.. "The sympathetic neuro-adipose connection and the control of body weight". Experimental Cell Research (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85016042784&partnerID=MN8TOARS.
    10.1016/j.yexcr.2017.03.047
  19. Barateiro, A.; Mahú, I.; Domingos, A.I.. "Leptin resistance and the neuro-adipose connection". Frontiers in Endocrinology 8 MAR (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85017107612&partnerID=MN8TOARS.
    10.3389/fendo.2017.00045
  20. Pereira, M.M.A.; Mahú, I.; Seixas, E.; Martinéz-Sánchez, N.; Kubasova, N.; Pirzgalska, R.M.; Cohen, P.; et al. "A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages". Nature Communications 8 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85017004495&partnerID=MN8TOARS.
    10.1038/ncomms14967
  21. Huang, W.; Thomas, B.; Flynn, R.A.; Gavzy, S.J.; Wu, L.; Kim, S.V.; Hall, J.A.; et al. "Corrigendum: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions". Nature 533 7601 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84966364917&partnerID=MN8TOARS.
    10.1038/nature16968
  22. Sano, T.; Huang, W.; Hall, J.A.; Yang, Y.; Chen, A.; Gavzy, S.J.; Lee, J.-Y.; et al. "Erratum: An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses (Cell (2015) 163 (381-393))". Cell 164 1-2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84954289194&partnerID=MN8TOARS.
    10.1016/j.cell.2015.12.047
  23. Reis, B.S.; Lee, K.; Fanok, M.H.; Mascaraque, C.; Amoury, M.; Cohn, L.B.; Rogoz, A.; et al. "Leptin receptor signaling in T cells is required for Th17 differentiation". Journal of Immunology 194 11 (2015): 5253-5260. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929649679&partnerID=MN8TOARS.
    10.4049/jimmunol.1402996
  24. Sano, T.; Huang, W.; Hall, J.A.; Yang, Y.; Chen, A.; Gavzy, S.J.; Lee, J.-Y.; et al. "An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses". Cell 163 2 (2015): 381-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943638660&partnerID=MN8TOARS.
    10.1016/j.cell.2015.08.061
  25. Huang, W.; Thomas, B.; Flynn, R.A.; Gavzy, S.J.; Wu, L.; Kim, S.V.; Hall, J.A.; et al. "DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions". Nature 528 7583 (2015): 517-522. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951288125&partnerID=MN8TOARS.
    10.1038/nature16193
  26. Zeng, W.; Pirzgalska, R.M.; Pereira, M.M.A.; Kubasova, N.; Barateiro, A.; Seixas, E.; Lu, Y.-H.; et al. "Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis". Cell 163 1 (2015): 84-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944733460&partnerID=MN8TOARS.
    10.1016/j.cell.2015.08.055
  27. Kubasova, N.; Burdakov, D.; Domingos, A.I.. "Sweet and low on leptin: Hormonal regulation of sweet taste buds". Diabetes 64 11 (2015): 3651-3652. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956851300&partnerID=MN8TOARS.
    10.2337/dbi15-0004
  28. "Cellular and molecular basis of decision-making". EMBO reports (2014): http://dx.doi.org/10.15252/embr.201438993.
    10.15252/embr.201438993
  29. Domingos, A.I.; Vaynshteyn, J.; Sordillo, A.; Friedman, J.M.. "The reward value of sucrose in leptin-deficient obese mice". Molecular Metabolism 3 1 (2014): 73-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895141804&partnerID=MN8TOARS.
    10.1016/j.molmet.2013.10.007
  30. Domingos, A.I.; Sordillo, A.; Dietrich, M.O.; Liu, Z.-W.; Tellez, L.A.; Vaynshteyn, J.; Ferreira, J.G.; et al. "Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar". eLife 2013 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891822239&partnerID=MN8TOARS.
    10.7554/eLife.01462
  31. "Lean on Leptin or Lean for Sugar". Journal of Obesity & Weight Loss Therapy (2013): http://dx.doi.org/10.4172/2165-7904.1000166.
    10.4172/2165-7904.1000166
  32. Stanley, S.; Domingos, A.I.; Kelly, L.; Garfield, A.; Damanpour, S.; Heisler, L.; Friedman, J.. "Profiling of glucose-sensing neurons reveals that ghrh neurons are activated by hypoglycemia". Cell Metabolism 18 4 (2013): 596-607. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885145339&partnerID=MN8TOARS.
    10.1016/j.cmet.2013.09.002
  33. Chaudhury, D.; Walsh, J.J.; Friedman, A.K.; Juarez, B.; Ku, S.M.; Koo, J.W.; Ferguson, D.; et al. "Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons". Nature 493 7433 (2013): 532-536. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872925363&partnerID=MN8TOARS.
    10.1038/nature11713
  34. Domingos, A.I.; Vaynshteyn, J.; Voss, H.U.; Ren, X.; Gradinaru, V.; Zang, F.; Deisseroth, K.; De Araujo, I.E.; Friedman, J.. "Leptin regulates the reward value of nutrient". Nature Neuroscience 14 12 (2011): 1562-1568. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255186756&partnerID=MN8TOARS.
    10.1038/nn.2977
  35. Fishilevich, E.; Domingos, A.I.; Asahina, K.; Naef, F.; Vosshall, L.B.; Louis, M.. "Chemotaxis behavior mediated by single larval olfactory neurons in Drosophila". Current Biology 15 23 (2005): 2086-2096. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444462215&partnerID=MN8TOARS.
    10.1016/j.cub.2005.11.016
  36. Larsson, M.C.; Domingos, A.I.; Jones, W.D.; Chiappe, M.E.; Amrein, H.; Vosshall, L.B.. "Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction". Neuron 43 5 (2004): 703-714. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444222660&partnerID=MN8TOARS.
    10.1016/j.neuron.2004.08.019
Pré-impressão
  1. Conan J O O’Brien; Giorgio Ratti; Emma Haberman; Charles Sweeney; Siamon Gordon; Ana I Domingos. "MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production". 2023. https://doi.org/10.7554/eLife.91318.1.
    10.7554/eLife.91318.1
  2. Conan J O O’Brien; Giorgio Ratti; Emma Haberman; Charles Sweeney; Siamon Gordon; Ana I Domingos. "MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production". 2023. https://doi.org/10.7554/eLife.91318.
    10.7554/eLife.91318
  3. Conan J O O’Brien; Giorgio Ratti; Emma Haberman; Charles Sweeney; Siamon Gordon; Ana I Domingos. "MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production". 2023. https://doi.org/10.1101/2023.09.26.559578.
    10.1101/2023.09.26.559578
Resumo em conferência
  1. "Distress, brain metabolism, and inflammatory processes: A study with metastatic breast cancer patients". 2018.
    10.1002/pon.4878
Atividades

Membro de associação

Nome da associação Tipo de participação
2022/07/01 - Atual American Physiological Society Editor in Chief (AJP- Endocrinology and Metabolism) - https://journals.physiology.org/ajpendo/edboard

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2020/09/09 - Atual Member of the Advisory Board (Cell Metabolism)
Outro
 Cell Press, Estados Unidos
2019/01/01 - Atual Member of Board of Reviewing Editors (eLife)
Outro
 eLife Sciences Publications Ltd, Reino Unido