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Viktor Korolchuk obtained his PhD from the Institute of Biochemistry in Kiev, Ukraine. During the postdoctoral training at Bristol and Cambridge Universities, UK, Viktor have been studying intracellular trafficking and signalling pathways using a range of biochemical, cell biological and genetic approaches. His contributions to the field include: isolation and characterisation of protein kinases associated with endocytic clathrin-coated vesicles (Traffic, 2002; J Biol Chem, 2005); studies of the topologically unusual protein tetherin, its trafficking and role in the development and maintenance of cell polarity (Traffic, 2003; J Cell Sci, 2007; J Cell Biol, 2009); the role of Drosophila trafficking proteins in the recycling of synaptic vesicles, in neuronal development and in regulation of signalling pathways (J Cell Biol, 2007; J Cell Sci, 2007); characterisation of several mechanisms of autophagy regulation including those by calcium, reactive oxygen species, reactive nitrogen species and in the context of a glycogen storage disease (Autophagy, 2009; Hum Mol Genet, 2010; Mol Cell, 2011); a mechanism of cross-talk between autophagy and the ubiquitin proteasome system (Mol Cell, 2009); a novel mechanism of coordinated control of both mTOR and autophagy by nutrients (Nat Cell Biol, 2011); identification of autophagy regulators that suppress the toxicity caused by mutant huntingtin.
Identificação

Identificação pessoal

Nome completo
Viktor Korolchuk

Nomes de citação

  • Korolchuk, Viktor

Identificadores de autor

Ciência ID
1712-3AB8-4A4A
ORCID iD
0000-0002-4071-592X

Moradas

  • Bioscience Institute, Faculty of Medical Sciences, Newcastle University, NE4 5PL, Newcastle, Newcastle upon Tyne, Reino Unido (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular
Formação
Grau Classificação
2000
Concluído
Biochemistry (Doktor (PhD))
Institut biohimii imeni O V Palladina Nacional'na akademia nauk Ukraini, Ucrânia
1996
Concluído
Master's Degree in Biology (Magistra)
Kiev State University, Ucrânia
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2007/01 - 2011/03 Investigador Contratado (Investigação) Cambridge Institute for Medical Research, Reino Unido
2004/01 - 2006/12 Investigador Contratado (Investigação) Cambridge University Department of Genetics, Reino Unido
2000/03 - 2003/12 Investigador Contratado (Investigação) Bristol University Department of Biochemistry, Reino Unido

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2017/08 - Atual Professor Catedrático (Docente Universitário) Newcastle University Institute for Cell and Molecular Biosciences, Reino Unido
2011/04 - 2017/07 Leitor (Docente Universitário) Newcastle University Institute for Cell and Molecular Biosciences, Reino Unido
Projetos

Bolsa

Designação Financiadores
2018/09 - 2022/09 Autophagy-mitochondria axis in skin senescence
BH174490
Investigador responsável
Em curso
2019/02 - 2022/01 Identification of Parkinson disease-specific mitochondrial pathogenesis for disease-modifying therapy
18KK0242
Investigador responsável
Em curso
2018/11 - 2021/10 Role of autophagy in the accumulation of defective mitochondria during ageing
BB/R008167/1
Investigador responsável
Em curso
2018/04 - 2020/03 Royal Society-Newton Mobility Grant between UK and China
IEC\NSFC\170125
Investigador responsável
2015/11 - 2018/10 Amino acid sensing by mTOR: molecular mechanisms and their deregulation in ageing
BB/M023389/1
Investigador responsável
2015/01 - 2016/12 Targeting the persistent activation of mTOR in B-RAF and NRas mutated melanoma as a novel therapeutic strategy
7002
Investigador responsável
2012/05 - 2015/05 Studies of cellular processes involved in the control of nutrient signalling and their relevance to ageing Biotechnology and Biological Sciences Research Council
Produções

Publicações

Artigo em revista
  1. Wan, Tengfei; Weir, Emma J.; Johnson, Mary; Korolchuk, Viktor I.; Saretzki, Gabriele C.. "Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson's disease associated with enhanced autophagy". Progress in Neurobiology 199 (2021): 101953. http://dx.doi.org/10.1016/j.pneurobio.2020.101953.
    10.1016/j.pneurobio.2020.101953
  2. Rabanal-Ruiz, Yoana; Byron, Adam; Wirth, Alexander; Madsen, Ralitsa; Sedlackova, Lucia; Hewitt, Graeme; Nelson, Glyn; et al. "mTORC1 activity is supported by spatial association with focal adhesions". Journal of Cell Biology 220 5 (2021): http://dx.doi.org/10.1083/jcb.202004010.
    10.1083/jcb.202004010
  3. Prentzell, Mirja Tamara; Rehbein, Ulrike; Cadena Sandoval, Marti; De Meulemeester, Ann-Sofie; Baumeister, Ralf; Brohée, Laura; Berdel, Bianca; et al. "G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling". Cell 184 3 (2021): 655-674.e27. http://dx.doi.org/10.1016/j.cell.2020.12.024.
    10.1016/j.cell.2020.12.024
  4. Erskine, Daniel; Koss, David; Korolchuk, Viktor I.; Outeiro, Tiago F.; Attems, Johannes; McKeith, Ian. "Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders". Acta Neuropathologica (2021): http://dx.doi.org/10.1007/s00401-021-02266-7.
    10.1007/s00401-021-02266-7
  5. Klionsky, D.J.; et al.. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy 8 (2021): 1-382.
    10.1080/15548627.2020.1797280
  6. Cerniauskas, Edvinas; Kurzawa-Akanbi, Marzena; Xie, Long; Hallam, Dean; Moya-Molina, Marina; White, Kathryn; Steel, David; et al. "Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function". STEM CELLS Translational Medicine 9 12 (2020): 1585-1603. http://dx.doi.org/10.1002/sctm.20-0211.
    10.1002/sctm.20-0211
  7. Korolchuk, Viktor I.; Goljanek-Whysall, Katarzyna. "Redox signalling in physiology, ageing and disease". Biogerontology 21 4 (2020): 411-414. http://dx.doi.org/10.1007/s10522-020-09885-9.
    10.1007/s10522-020-09885-9
  8. Korolchuk, Viktor I.; Sarkar, Sovan; Fanto, Manolis. "Autophagy in Neurodegenerative Diseases". Journal of Molecular Biology 432 8 (2020): 2445-2448. http://dx.doi.org/10.1016/j.jmb.2020.03.005.
    10.1016/j.jmb.2020.03.005
  9. Sedlackova, Lucia; Kelly, George; Korolchuk, Viktor I.. "The pROS of Autophagy in Neuronal Health". Journal of Molecular Biology 432 8 (2020): 2546-2559. http://dx.doi.org/10.1016/j.jmb.2020.01.020.
    10.1016/j.jmb.2020.01.020
  10. Sedlackova, Lucia; Korolchuk, Viktor I.. "The crosstalk of NAD, ROS and autophagy in cellular health and ageing". Biogerontology 21 3 (2020): 381-397. http://dx.doi.org/10.1007/s10522-020-09864-0.
    10.1007/s10522-020-09864-0
  11. Vucicevic, Ljubica; Misirkic, Maja; Ciric, Darko; Martinovic, Tamara; Jovanovic, Maja; Isakovic, Aleksandra; Markovic, Ivanka; et al. "Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells". Cellular and Molecular Life Sciences 77 17 (2019): 3383-3399. http://dx.doi.org/10.1007/s00018-019-03356-2.
    10.1007/s00018-019-03356-2
  12. Sedlackova, Lucia; Korolchuk, Viktor I.. "Mitochondrial quality control as a key determinant of cell survival". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866 4 (2019): 575-587. http://dx.doi.org/10.1016/j.bbamcr.2018.12.012.
    10.1016/j.bbamcr.2018.12.012
  13. Zhai, Nianhui; Liu, Kai; Li, Hu; Liu, Zixuan; Wang, Hong; Korolchuk, Viktor I.; Carroll, Bernadette; et al. "PCV2 replication promoted by oxidative stress is dependent on the regulation of autophagy on apoptosis". Veterinary Research 50 1 (2019): http://dx.doi.org/10.1186/s13567-019-0637-z.
    10.1186/s13567-019-0637-z
  14. Kucheryavenko, Olena; Nelson, Glyn; von Zglinicki, Thomas; Korolchuk, Viktor I.; Carroll, Bernadette. "The mTORC1-autophagy pathway is a target for senescent cell elimination". Biogerontology 20 3 (2019): 331-335. http://dx.doi.org/10.1007/s10522-019-09802-9.
    10.1007/s10522-019-09802-9
  15. Correia-Melo, Clara; Birch, Jodie; Fielder, Edward; Rahmatika, Dina; Taylor, Jennifer; Chapman, James; Lagnado, Anthony; et al. "Rapamycin improves healthspan but not inflammaging in nf¿b1-/- mice". Aging Cell 18 1 (2018): e12882. http://dx.doi.org/10.1111/acel.12882.
    10.1111/acel.12882
  16. Hase, Yoshiki; Chen, Aiqing; Bates, Letitia L.; Craggs, Lucinda J.L.; Yamamoto, Yumi; Gemmell, Elizabeth; Oakley, Arthur E.; Korolchuk, Viktor I.; Kalaria, Raj N.. "Severe white matter astrocytopathy in CADASIL". Brain Pathology 28 6 (2018): 832-843. http://dx.doi.org/10.1111/bpa.12621.
    10.1111/bpa.12621
  17. Otten, Elsje G.; Stefanatos, Rhoda; Carroll, Bernadette; Korolchuk, Viktor I.. "Oxidation of p62 as an evolutionary adaptation to promote autophagy in stress conditions". Cell Stress 2 4 (2018): 91-93. http://dx.doi.org/10.15698/cst2018.04.132.
    10.15698/cst2018.04.132
  18. Rabanal-Ruiz, Yoana; Korolchuk, Viktor. "mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome". International Journal of Molecular Sciences 19 3 (2018): 818. http://dx.doi.org/10.3390/ijms19030818.
    10.3390/ijms19030818
  19. Carroll, Bernadette; Korolchuk, Viktor I.. "Nutrient sensing, growth and senescence". The FEBS Journal 285 11 (2018): 1948-1958. http://dx.doi.org/10.1111/febs.14400.
    10.1111/febs.14400
  20. Carroll, Bernadette; Otten, Elsje G.; Manni, Diego; Stefanatos, Rhoda; Menzies, Fiona M.; Smith, Graham R.; Jurk, Diana; et al. "Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-017-02746-z.
    10.1038/s41467-017-02746-z
  21. Rabanal-Ruiz, Yoana; Otten, Elsje G.; Korolchuk, Viktor I.. "mTORC1 as the main gateway to autophagy". Essays in Biochemistry 61 6 (2017): 565-584. http://dx.doi.org/10.1042/ebc20170027.
    10.1042/ebc20170027
  22. Lane, Jon D.; Korolchuk, Viktor I.; Murray, James T.. "Signalling mechanisms in autophagy: an introduction to the issue". Essays in Biochemistry 61 6 (2017): 561-563. http://dx.doi.org/10.1042/ebc20170116.
    10.1042/ebc20170116
  23. Hallam, Dean; Collin, Joseph; Bojic, Sanja; Chichagova, Valeria; Buskin, Adriana; Xu, Yaobo; Lafage, Lucia; et al. "An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure". STEM CELLS 35 11 (2017): 2305-2320. http://dx.doi.org/10.1002/stem.2708.
    10.1002/stem.2708
  24. Carroll, Bernadette; Korolchuk, Viktor I.. "Dysregulation of mTORC1/autophagy axis in senescence". Aging 9 8 (2017): 1851-1852. http://dx.doi.org/10.18632/aging.101277.
    10.18632/aging.101277
  25. Korolchuk, Viktor I.; Miwa, Satomi; Carroll, Bernadette; von Zglinicki, Thomas. "Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?". EBioMedicine 21 (2017): 7-13. http://dx.doi.org/10.1016/j.ebiom.2017.03.020.
    10.1016/j.ebiom.2017.03.020
  26. Carroll, Bernadette; Nelson, Glyn; Rabanal-Ruiz, Yoana; Kucheryavenko, Olena; Dunhill-Turner, Natasha A.; Chesterman, Charlotte C.; Zahari, Qabil; et al. "Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing". Journal of Cell Biology 216 7 (2017): 1949-1957. http://dx.doi.org/10.1083/jcb.201610113.
    10.1083/jcb.201610113
  27. Hewitt, Graeme; Korolchuk, Viktor I.. "Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance". Trends in Cell Biology 27 5 (2017): 340-351. http://dx.doi.org/10.1016/j.tcb.2016.11.011.
    10.1016/j.tcb.2016.11.011
  28. Chen, Xingxiang; Che, Chaoping; Korolchuk, Viktor I.; Gan, Fang; Pan, Cuiling; Huang, Kehe. "Selenomethionine Alleviates AFB1-Induced Damage in Primary Chicken Hepatocytes by Inhibiting CYP450 1A5 Expression via Upregulated SelW Expression". Journal of Agricultural and Food Chemistry 65 12 (2017): 2495-2502. http://dx.doi.org/10.1021/acs.jafc.6b05308.
    10.1021/acs.jafc.6b05308
  29. Hewitt, Graeme; Carroll, Bernadette; Sarallah, Rezazadeh; Correia-Melo, Clara; Ogrodnik, Mikolaj; Nelson, Glyn; Otten, Elsje G.; et al. "SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair". Autophagy 12 10 (2016): 1917-1930. http://dx.doi.org/10.1080/15548627.2016.1210368.
    10.1080/15548627.2016.1210368
  30. Brown, Anna; Patel, Siddharth; Ward, Carl; Lorenz, Anna; Ortiz, Mauren; DuRoss, Allison; Wieghardt, Fabian; et al. "PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep31750.
    10.1038/srep31750
  31. Santin, Yohan; Sicard, Pierre; Vigneron, François; Guilbeau-Frugier, Céline; Dutaur, Marianne; Lairez, Olivier; Couderc, Bettina; et al. "Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure". Antioxidants & Redox Signaling 25 1 (2016): 10-27. http://dx.doi.org/10.1089/ars.2015.6522.
    10.1089/ars.2015.6522
  32. Ward, Carl; Martinez-Lopez, Nuria; Otten, Elsje G.; Carroll, Bernadette; Maetzel, Dorothea; Singh, Rajat; Sarkar, Sovan; Korolchuk, Viktor I.. "Autophagy, lipophagy and lysosomal lipid storage disorders". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861 4 (2016): 269-284. http://dx.doi.org/10.1016/j.bbalip.2016.01.006.
    10.1016/j.bbalip.2016.01.006
  33. Correia-Melo, Clara; Marques, Francisco DM; Anderson, Rhys; Hewitt, Graeme; Hewitt, Rachael; Cole, John; Carroll, Bernadette M; et al. "Mitochondria are required for pro-ageing features of the senescent phenotype". The EMBO Journal 35 7 (2016): 724-742. http://dx.doi.org/10.15252/embj.201592862.
    10.15252/embj.201592862
  34. Carroll, Bernadette; Maetzel, Dorothea; Maddocks, Oliver DK; Otten, Gisela; Ratcliff, Matthew; Smith, Graham R; Dunlop, Elaine A; et al. "Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity". eLife 5 (2016): http://dx.doi.org/10.7554/elife.11058.
    10.7554/elife.11058
  35. Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://dx.doi.org/10.1080/15548627.2015.1100356.
    10.1080/15548627.2015.1100356
  36. Vicinanza, Mariella; Korolchuk, Viktor I.; Ashkenazi, Avraham; Puri, Claudia; Menzies, Fiona M.; Clarke, Jonathan H.; Rubinsztein, David C.. "PI(5)P Regulates Autophagosome Biogenesis". Molecular Cell 57 2 (2015): 219-234. http://dx.doi.org/10.1016/j.molcel.2014.12.007.
    10.1016/j.molcel.2014.12.007
  37. Lu, Wei; Zhang, Yu; McDonald, David O.; Jing, Huie; Carroll, Bernadette; Robertson, Nic; Zhang, Qian; et al. "Dual Proteolytic Pathways Govern Glycolysis and Immune Competence". Cell 159 7 (2014): 1578-1590. http://dx.doi.org/10.1016/j.cell.2014.12.001.
    10.1016/j.cell.2014.12.001
  38. Dalle Pezze, Piero; Nelson, Glyn; Otten, Elsje G.; Korolchuk, Viktor I.; Kirkwood, Thomas B. L.; von Zglinicki, Thomas; Shanley, Daryl P.. "Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions". PLoS Computational Biology 10 8 (2014): e1003728. http://dx.doi.org/10.1371/journal.pcbi.1003728.
    10.1371/journal.pcbi.1003728
  39. Carroll, Bernadette; Korolchuk, Viktor I.; Sarkar, Sovan. "Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis". Amino Acids 47 10 (2014): 2065-2088. http://dx.doi.org/10.1007/s00726-014-1775-2.
    10.1007/s00726-014-1775-2
  40. Sarkar, Sovan; Maetzel, Dorothea; Korolchuk, Viktor I; Jaenisch, Rudolf. "Restarting stalled autophagy a potential therapeutic approach for the lipid storage disorder, Niemann-Pick type C1 disease". Autophagy 10 6 (2014): 1137-1140. http://dx.doi.org/10.4161/auto.28623.
    10.4161/auto.28623
  41. Sarkar, Sovan; Carroll, Bernadette; Buganim, Yosef; Maetzel, Dorothea; Ng, Alex H.M.; Cassady, John P.; Cohen, Malkiel A.; et al. "Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease". Cell Reports 5 5 (2013): 1302-1315. http://dx.doi.org/10.1016/j.celrep.2013.10.042.
    10.1016/j.celrep.2013.10.042
  42. Carroll, Bernadette; Hewitt, Graeme; Korolchuk, Viktor I.. "Autophagy and ageing: implications for age-related neurodegenerative diseases". Essays in Biochemistry 55 (2013): 119-131. http://dx.doi.org/10.1042/bse0550119.
    10.1042/bse0550119
  43. Ivanov, Andre; Pawlikowski, Jeff; Manoharan, Indrani; van Tuyn, John; Nelson, David M.; Rai, Taranjit Singh; Shah, Parisha P.; et al. "Lysosome-mediated processing of chromatin in senescence". Journal of Cell Biology 202 1 (2013): 129-143. http://dx.doi.org/10.1083/jcb.201212110.
    10.1083/jcb.201212110
  44. Jurk, Diana; Wang, Chunfang; Miwa, Satomi; Maddick, Mandy; Korolchuk, Viktor; Tsolou, Avgi; Gonos, Efstathios S.; et al. "Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response". Aging Cell 11 6 (2012): 996-1004. http://dx.doi.org/10.1111/j.1474-9726.2012.00870.x.
    10.1111/j.1474-9726.2012.00870.x
  45. Korolchuk, Viktor I.; Rubinsztein, David C.. "It's time to eat yourself healthy: On signals controlling autophagy". The Biochemist 34 2 (2012): 8-13. http://dx.doi.org/10.1042/bio03402008.
    10.1042/bio03402008
  46. Klionsky, Daniel J.; Abdalla, Fabio C.; Abeliovich, Hagai; Abraham, Robert T.; Acevedo-Arozena, Abraham; Adeli, Khosrow; Agholme, Lotta; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy". Autophagy 8 4 (2012): 445-544. http://dx.doi.org/10.4161/auto.19496.
    10.4161/auto.19496
  47. Korolchuk, Viktor I.; Rubinsztein, David C.. "Regulation of autophagy by lysosomal positioning". Autophagy 7 8 (2011): 927-928. http://dx.doi.org/10.4161/auto.7.8.15862.
    10.4161/auto.7.8.15862
  48. Sarkar, Sovan; Korolchuk, Viktor I.; Renna, Maurizio; Imarisio, Sara; Fleming, Angeleen; Williams, Andrea; Garcia-Arencibia, Moises; et al. "Complex Inhibitory Effects of Nitric Oxide on Autophagy". Molecular Cell 43 1 (2011): 19-32. http://dx.doi.org/10.1016/j.molcel.2011.04.029.
    10.1016/j.molcel.2011.04.029
  49. Rocha, João J. E.; Korolchuk, Viktor I.; Robinson, Iain M.; O'Kane, Cahir J.. "A Phagocytic Route for Uptake of Double-Stranded RNA in RNAi". PLoS ONE 6 4 (2011): e19087. http://dx.doi.org/10.1371/journal.pone.0019087.
    10.1371/journal.pone.0019087
  50. Korolchuk, Viktor I.; Saiki, Shinji; Lichtenberg, Maike; Siddiqi, Farah H.; Roberts, Esteban A.; Imarisio, Sara; Jahreiss, Luca; et al. "Lysosomal positioning coordinates cellular nutrient responses". Nature Cell Biology 13 4 (2011): 453-460. http://dx.doi.org/10.1038/ncb2204.
    10.1038/ncb2204
  51. Knecht, Erwin; Aguado, Carmen; Sarkar, Sovan; Korolchuk, Viktor I.; Criado-García, Olga; Vernia, Santiago; Boya, Patricia; et al. "Impaired autophagy in Lafora disease". Autophagy 6 7 (2010): 991-993. http://dx.doi.org/10.4161/auto.6.7.13308.
    10.4161/auto.6.7.13308
  52. Ravikumar, Brinda; Sarkar, Sovan; Davies, Janet E.; Futter, Marie; Garcia-Arencibia, Moises; Green-Thompson, Zeyn W.; Jimenez-Sanchez, Maria; et al. "Regulation of Mammalian Autophagy in Physiology and Pathophysiology". Physiological Reviews 90 4 (2010): 1383-1435. http://dx.doi.org/10.1152/physrev.00030.2009.
    10.1152/physrev.00030.2009
  53. Underwood, B. R.; Imarisio, S.; Fleming, A.; Rose, C.; Krishna, G.; Heard, P.; Quick, M.; et al. "Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease". Human Molecular Genetics 19 17 (2010): 3413-3429. http://dx.doi.org/10.1093/hmg/ddq253.
    10.1093/hmg/ddq253
  54. Aguado, Carmen; Sarkar, Sovan; Korolchuk, Viktor I.; Criado, Olga; Vernia, Santiago; Boya, Patricia; Sanz, Pascual; et al. "Laforin, the most common protein mutated in Lafora disease, regulates autophagy". Human Molecular Genetics 19 14 (2010): 2867-2876. http://dx.doi.org/10.1093/hmg/ddq190.
    10.1093/hmg/ddq190
  55. Knecht, E.; Aguado, C.; Sarkar, S.; Korolchuk, V.I.; Criado-García, O.; Vernia, S.; Boya, P.; et al. "Impaired autophagy in Lafora disease". Autophagy 6 7 (2010): 991-993. https://doi.org/10.4161/auto.6.7.13308.
    10.4161/auto.6.7.13308
  56. Korolchuk, Viktor I.; Menzies, Fiona M.; Rubinsztein, David C.. "Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems". FEBS Letters 584 7 (2009): 1393-1398. http://dx.doi.org/10.1016/j.febslet.2009.12.047.
    10.1016/j.febslet.2009.12.047
  57. Korolchuk, Viktor I.; Menzies, Fiona M.; Rubinsztein, David C.. "A novel link between autophagy and the ubiquitin-proteasome system". Autophagy 5 6 (2009): 862-863. http://dx.doi.org/10.4161/auto.8840.
    10.4161/auto.8840
  58. Rubinsztein, David C.; Cuervo, Ana Maria; Ravikumar, Brinda; Sarkar, Sovan; Korolchuk, Viktor I.; Kaushik, Susmita; Klionsky, Daniel J.. "In search of an “autophagomometer”". Autophagy 5 5 (2009): 585-589. http://dx.doi.org/10.4161/auto.5.5.8823.
    10.4161/auto.5.5.8823
  59. Ravikumar, B.; Futter, M.; Jahreiss, L.; Korolchuk, V. I.; Lichtenberg, M.; Luo, S.; Massey, D. C. O.; et al. "Mammalian macroautophagy at a glance". Journal of Cell Science 122 11 (2009): 1707-1711. http://dx.doi.org/10.1242/jcs.031773.
    10.1242/jcs.031773
  60. Sarkar, Sovan; Korolchuk, Viktor I.; Renna, Maurizio; Winslow, Ashley R.; Rubinsztein, David C.. "Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates". Autophagy 5 3 (2009): 307-313. http://dx.doi.org/10.4161/auto.5.3.7664.
    10.4161/auto.5.3.7664
  61. Rollason, Ruth; Korolchuk, Viktor; Hamilton, Clare; Jepson, Mark; Banting, George. "A CD317/tetherin–RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells". Journal of Cell Biology 184 5 (2009): 721-736. http://dx.doi.org/10.1083/jcb.200804154.
    10.1083/jcb.200804154
  62. Korolchuk, Viktor I.; Mansilla, Alicia; Menzies, Fiona M.; Rubinsztein, David C.. "Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates". Molecular Cell 33 4 (2009): 517-527. http://dx.doi.org/10.1016/j.molcel.2009.01.021.
    10.1016/j.molcel.2009.01.021
  63. Korolchuk, V.I.; Menzies, F.M.; Rubinsztein, D.C.. "A novel link between autophagy and the ubiquitin-proteasome system". Autophagy 5 6 (2009): 862-863. https://doi.org/10.4161/auto.8840.
  64. Imarisio, Sara; Carmichael, Jenny; Korolchuk, Viktor; Chen, Chien-Wen; Saiki, Shinji; Rose, Claudia; Krishna, Gauri; et al. "Huntington's disease: from pathology and genetics to potential therapies". Biochemical Journal 412 2 (2008): 191-209. http://dx.doi.org/10.1042/bj20071619.
    10.1042/bj20071619
  65. Korolchuk, V. I.; Schutz, M. M.; Gomez-Llorente, C.; Rocha, J.; Lansu, N. R.; Collins, S. M.; Wairkar, Y. P.; Robinson, I. M.; O'Kane, C. J.. "Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation". Journal of Cell Science 120 24 (2007): 4367-4376. http://dx.doi.org/10.1242/jcs.012336.
    10.1242/jcs.012336
  66. Rollason, R.; Korolchuk, V.; Hamilton, C.; Schu, P.; Banting, G.. "Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif". Journal of Cell Science 120 21 (2007): 3850-3858. http://dx.doi.org/10.1242/jcs.003343.
    10.1242/jcs.003343
  67. Koh, Tong-Wey; Korolchuk, Viktor I.; Wairkar, Yogesh P.; Jiao, Wei; Evergren, Emma; Pan, Hongling; Zhou, Yi; et al. "Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development". Journal of Cell Biology 178 2 (2007): 309-322. http://dx.doi.org/10.1083/jcb.200701030.
    10.1083/jcb.200701030
  68. Korolchuk, Viktor I.; Cozier, Gyles; Banting, George. "Regulation of CK2 Activity by Phosphatidylinositol Phosphates". Journal of Biological Chemistry 280 49 (2005): 40796-40801. http://dx.doi.org/10.1074/jbc.m508988200.
    10.1074/jbc.m508988200
  69. Palmer, Claire L.; Lim, Wonil; Hastie, Peter G.R.; Toward, Marie; Korolchuk, Viktor I.; Burbidge, Stephen A.; Banting, George; et al. "Hippocalcin Functions as a Calcium Sensor in Hippocampal LTD". Neuron 47 4 (2005): 487-494. http://dx.doi.org/10.1016/j.neuron.2005.06.014.
    10.1016/j.neuron.2005.06.014
  70. Kupzig, Sabine; Korolchuk, Viktor; Rollason, Ruth; Sugden, Anna; Wilde, Andrew; Banting, George. "Bst-2/HM1.24 Is a Raft-Associated Apical Membrane Protein with an Unusual Topology". Traffic 4 10 (2003): 694-709. http://dx.doi.org/10.1034/j.1600-0854.2003.00129.x.
    10.1034/j.1600-0854.2003.00129.x
  71. Korolchuk, V.; Banting, G.. "Kinases in clathrin-mediated endocytosis". Biochemical Society Transactions 31 4 (2003): 857-860. http://dx.doi.org/10.1042/bst0310857.
    10.1042/bst0310857
  72. Korolchuk, Viktor I.; Banting, George. "CK2 and GAK/auxilin2 Are Major Protein Kinases in Clathrin-Coated Vesicles". Traffic 3 6 (2002): 428-439. http://dx.doi.org/10.1034/j.1600-0854.2002.30606.x.
    10.1034/j.1600-0854.2002.30606.x
Capítulo de livro
  1. Rabanal-Ruiz, Yoana; Korolchuk, Viktor. "The role of lysosomes in autophagy". In Autophagy in Health and Disease. 2021.
  2. Pattison, Charlotte J.; Korolchuk, Viktor I.. "Autophagy: ‘Self-Eating’ Your Way to Longevity". In Biochemistry and Cell Biology of Ageing: Part I Biomedical Science, 25-47. Springer Singapore, 2018.
    10.1007/978-981-13-2835-0_2
  3. Otten, Elsje G.; Manni, Diego; Korolchuk, Viktor I.. "Mitochondrial Degradation, Autophagy and Neurodegenerative Disease". In Mitochondrial Dysfunction in Neurodegenerative Disorders, 255-278. Springer International Publishing, 2016.
    10.1007/978-3-319-28637-2_11
  4. Hewitt, Graeme; Carroll, Bernadette; Korolchuk, Viktor I.. "Mechanisms of Cross-Talk between Intracellular Protein Degradation Pathways". In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 103-119. Elsevier, 2015.
    10.1016/b978-0-12-801032-7.00005-8
Resumo em conferência
  1. Korolchuk, Viktor. "Cellular functions of autophagy and their relevance to ageing". Trabalho apresentado em 1st Meeting on Vesicular Biology, 2018.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019 mTOR and lysosome: two pillars of nutrient sensing 23rd Meeting of Signal Transduction Society
2019 Redox regulation of autophagy in neurodegenerative diseases FENS regional meeting
2018 Oxidation of receptor proteins as a general mechanism regulating selective autophagy 83rd Harden conference on Autophagy
Biochemical Society
2018 Evolution of selective autophagy as a mechanism of oxidative stress response. Proteostatic Mechanisms in Health and Disease Final COST Action Proteostasis Meeting
2018 Cellular functions of autophagy and their relevance to ageing 1st Meeting on Vesicular Biology
2017 mTOR and autophagy: two pillars of senescence program 8th Annual Alliance for Healthy Aging Conference
2017 Autophagy-mitochondria axis in health in disease The Physiological Society topic Meeting ‘Mitochondria: Form and function’
2016 New insights in ageing: The relevance of autophagy to ageing and age-related neurodegeneration AMWC

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2019 - 2019 Joint Biochemical Society and BSRA Scientific Meeting on Redox Signalling in Physiology, Ageing and Disease (2019/07/01 - 2019/07/03) Newcastle University, Reino Unido
2012 - 2019 Molecular Biology of Ageing research seminar (2012 - 2019)
Seminário
Newcastle University Institute for Cell and Molecular Biosciences, Reino Unido
2012 - 2017 Molecules, Genes and Cells Club (2012 - 2017)
Seminário
Newcastle University School of Biomedical Sciences, Reino Unido

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2020 - Atual Redox regulation of selective autophagy
Nanjing Medical University, China
2019 - Atual Autophagy as a mechanism of oxidative stress response
Durham University, Reino Unido
2019 - Atual Redox regulation of autophagy
University College of London, Reino Unido
2019 - Atual Autophagy as a mechanism of oxidative stress response
Universidad de Salamanca Facultad de Medicina, Espanha
2019 - 2020 Summer School on Biology of Ageing
Universidade de Coimbra, Portugal
2019 - 2019 Turning the tables on oxidative stress with autophagy
Birmingham City University, Reino Unido
2018 - 2018 Lysosome as a hub of nutrient sensing
Deutsches Krebsforschungszentrum, Alemanha
2018 - 2018 Turning the tables on oxidative stress: how cells have adapted autophagy to harness oxidation and promote cell survival
Kings College of London Institute of Psychiatry, Psychology and Neuroscience, Reino Unido
2018 - 2018 Cellular functions of autophagy and their relevance to ageing
Universidade de Aveiro Instituto de Biomedicina, Portugal
2017 - 2017 Autophagy, mTOR and ageing: The good, the bad and the ugly
Københavns Universitet Center for Sund Aldring, Dinamarca
2017 - 2017 Mechanistic insights into mTOR and autophagy in ageing
Nanjing Medical University, China
2017 - 2017 Mechanistic insights into mTORC1 and autophagy during ageing
Max Plank Institut für Altern, Alemanha
2016 - 2016 Mechanisms of amino acid sensing by mTOR and their deregulation in senescence
Beatson Institute for Cancer Research, Reino Unido
2016 - 2016 Amino acids and regulation of mTOR
Cardiff University, Reino Unido
2016 - 2016 Mechanisms of amino acid sensing by mTOR
Cambridge University Institute for Metabolic Science, Reino Unido
2014 - 2014 Summer School on Biology of Ageing
Universidade de Coimbra, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2018 - 2018 9th Annual Alliance for Health Aging Conference
2018 - 2018 83rd Harden Conference on Autophagy
2016 - 2016 BSRA Ageing conference
2016 - 2016 AMWC
2014 - 2014 Gordon Research Symposium on Autophagy

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019 - Atual Subcellular Biochemistry Springer
2018 - Atual International Journal of Biochemistry and Cell Biology Elsevier
2020 - 2020 Journal of Molecular Biology - Special Issue on Autophagy and Neurodegeneration
2018 - 2019 Biochemistry and Cell Biology of Ageing, Springer Subcellular Biochemistry series Springer
2017 - 2017 Essays in Biochemistry - Issue on Ageing
2017 - 2017 Essays in Biochemistry - Issue on Autophagy

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2017 - Atual Stage II Biology of Ageing module (Licence) Newcastle University Faculty of Medical Sciences, Reino Unido
2017 - 2019 Stage II MBBS Ageing module (Licence) Newcastle University Faculty of Medical Sciences, Reino Unido

Membro de associação

Nome da associação Tipo de participação
2009 - Atual Biochemical Society
2009 - Atual British Society for Cell Biology
2016 - 2020 British Society for Research on Ageing Executive Board member

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2006 - Atual Alzheimer's Research UK Research Network
Membro
2020 - 2020 Review of a Collaborative Research Centre for German Research Foundation (DFG), Heidelberg, Germany
2017 - 2020 European COST Action TRANSAUTOPHAGY
Membro
2019 - 2019 Mid-Term Review of major investments at the BBSRC strategically-funded institutes, London, UK
2014 - 2018 UK deputy representative in European COST Action PROTEOSTASIS
Consultor

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2020 - 2020 Panel member of the selection committee for the group leader positions Universitat de Barcelona - Campus Mundet, Espanha
2020 - 2020 Panel member of the selection committee for the Lectureship positions Newcastle University, Reino Unido

Tutoria

Tópico Nome do aluno
2000 - Atual Extensive experience in project design and mentoring for postgraduate and undergraduate students -